RIBOZYME PHARMACEUTICALS INC
SC 13D/A, 1997-01-08
PHARMACEUTICAL PREPARATIONS
Previous: DEFINED ASSET FUNDS MUN INVT TR FD MULTISTATE SERIES 17, 485BPOS, 1997-01-08
Next: ULTRAFEM INC, DEF 14A, 1997-01-08



<PAGE>   1
                                                                   Page 1 of 16

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20459

                                  SCHEDULE 13D
                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 2)

                         RIBOZYME PHARMACEUTICALS, INC.
                                (Name of Issuer)

                    COMMON STOCK, $0.01 PAR VALUE PER SHARE
                         (Title of Class of Securities)

                                   76256710-5
                     (CUSIP Number of Class of Securities)

                                 Thomas A. Mann
                             4920 Commerce Parkway
                        Warrensville Heights, OH  44128

                                with a copy to:

                            Warren Goldenberg, Esq.
                             3300 BP America Bldg.
                               200 Public Square
                             Cleveland, Ohio  44114
                                 (216) 621-0150

                 (Name, address and telephone number of persons
                authorized to receive notices and communications
                    on behalf of person(s) filing statement)

                               DECEMBER 23, 1996
            (Date of Event which Requires Filing of this Statement)

________________________________________________________________________________


         If the filing person has previously filed a statement on Schedule 13G
to report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-l(b)(3) or (4), check the following
box [ ].

         Note: Six copies of this statement, including all exhibits, should be
filed with the Commission. See Rule 13d-1(a) for other parties to whom copies
are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).

                        (Continued on following page(s))
                               Page 1 of 16 Pages
                            Exhibit Index on Page 12

<PAGE>   2
                                                                    Page 2 of 16



CUSIP No. 76256710-5
________________________________________________________________________________
1.       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NOS. OF REPORTING PERSON

         THOMAS A. MANN -- SSN####-##-####
________________________________________________________________________________
2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                      (a)   [ X]
                                                                      (b)    [ ]
________________________________________________________________________________
3.       SEC USE ONLY

________________________________________________________________________________
4.       SOURCE OF FUNDS

         OO
________________________________________________________________________________
5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) OR 2(e)
                                                                             [ ]
________________________________________________________________________________
6.       CITIZENSHIP OR PLACE OF ORGANIZATION

         U.S.A.
________________________________________________________________________________
                                  7.       SOLE VOTING POWER
NUMBER OF SHARES
BENEFICIALLY                               247,896
OWNED BY EACH
REPORTING PERSON                  ______________________________________________
WITH                              8.       SHARED VOTING POWER
                
                                           -0-
                                  ______________________________________________
                                  9.       SOLE DISPOSITIVE POWER

                                           247,896
                                  ______________________________________________
                                  10.      SHARED DISPOSITIVE POWER

                                           -0-
________________________________________________________________________________
11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         247,896
________________________________________________________________________________
12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                             [ ]
________________________________________________________________________________
13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         3.6%
________________________________________________________________________________
14.      TYPE OF REPORTING PERSON

         IN
________________________________________________________________________________

<PAGE>   3
                                                                    Page 3 of 16



CUSIP No. 76256710-5
________________________________________________________________________________
1.       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NOS. OF REPORTING PERSON

         A.P. VENTURE I CORP. -- EIN# 25-1540691
________________________________________________________________________________
2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                      (a)   [ X]
                                                                      (b)    [ ]
________________________________________________________________________________
3.       SEC USE ONLY

________________________________________________________________________________
4.       SOURCE OF FUNDS

         OO
________________________________________________________________________________
5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) OR 2(e)
                                                                             [ ]
________________________________________________________________________________
6.       CITIZENSHIP OR PLACE OF ORGANIZATION

         DELAWARE
________________________________________________________________________________
                                  7.       SOLE VOTING POWER
NUMBER OF SHARES
BENEFICIALLY                               93,147
OWNED BY EACH
REPORTING PERSON                  ______________________________________________
WITH                              8.       SHARED VOTING POWER
                
                                           -0-
                                  ______________________________________________
                                  9.       SOLE DISPOSITIVE POWER

                                           93,147
                                  ______________________________________________
                                  10.      SHARED DISPOSITIVE POWER

                                           -0-
________________________________________________________________________________
11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         93,147
________________________________________________________________________________
12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                             [ ]
________________________________________________________________________________
13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         1.3%
________________________________________________________________________________
14.      TYPE OF REPORTING PERSON

         CO
________________________________________________________________________________




<PAGE>   4
                                                                    Page 4 of 16



CUSIP No. 76256710-5
________________________________________________________________________________
1.       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NOS. OF REPORTING PERSON

         THE THOMAS A. AND DIANN G. MANN FOUNDATION-TAX ID# 34-1847977
________________________________________________________________________________
2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                                      (a)   [ X]
                                                                      (b)    [ ]
________________________________________________________________________________
3.       SEC USE ONLY

________________________________________________________________________________
4.       SOURCE OF FUNDS

         OO
________________________________________________________________________________
5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) OR 2(e)
                                                                             [ ]
________________________________________________________________________________
6.       CITIZENSHIP OR PLACE OF ORGANIZATION

         OHIO
________________________________________________________________________________
                                  7.       SOLE VOTING POWER
NUMBER OF SHARES
BENEFICIALLY                               -0-
OWNED BY EACH
REPORTING PERSON                  ______________________________________________
WITH                              8.       SHARED VOTING POWER
                
                                           -0-
                                  ______________________________________________
                                  9.       SOLE DISPOSITIVE POWER

                                           -0-
                                  ______________________________________________
                                  10.      SHARED DISPOSITIVE POWER

                                           -0-
________________________________________________________________________________
11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         -0-
________________________________________________________________________________
12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                             [ ]
________________________________________________________________________________
13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         0.0%
________________________________________________________________________________
14.      TYPE OF REPORTING PERSON

         CO
________________________________________________________________________________

<PAGE>   5
                                                                    Page 5 of 16



                               AMENDMENT NO. 2 TO
                                  SCHEDULE 13D

         This Amendment No. 2 to Schedule 13D is filed on behalf of Thomas A.
Mann, AP Venture I Corp., a Delaware corporation ("APVI"), the Trustees of
Amherst College, a Massachusetts non-profit corporation ("Amherst College") and
The Thomas A. and Diann G.  Mann Foundation, an Ohio non-profit corporation
(the "Foundation") (all of the foregoing persons and entities are hereinafter
referred to jointly as the "Reporting Persons").  This Amendment No. 2 to
Schedule 13D is filed on behalf of the Reporting Persons relative to
transactions in certain common stock, $0.01 par value per share (the "Common
Stock"), issued by Ribozyme Pharmaceuticals, Inc., a corporation organized
under the laws of the State of Delaware (the "Issuer").

ITEM 2.  IDENTITY AND BACKGROUND.

         Item 2. is amended and supplemented by the deletion of paragraphs (4),
(5) and (6) describing Amherst College, Solway Investments Limited and Pine
Street Partners II.  Each of the foregoing entities terminated its
participation in the coordination of possible sales of all or some portion of
the shares of the Common Stock held by the Reporting Persons and ceased to be a
Reporting Person by delivery of a letter to Thomas A. Mann on December 23, 1996
in accordance with the terms of that certain Joint Filing Agreement dated
October 16, 1996 among the Reporting Persons.

         Item 2. is further amended and supplemented by the insertion of a new
paragraph numbered (3) which reads, in its entirety, as follows:

         (3)     The Foundation is a non-profit corporation organized under the
                 laws of the State of Ohio which is operated exclusively for
                 charitable, religious, and scientific purposes, including, for
                 such purposes, the making of distributions to organizations
                 that are exempt from federal income taxation under Section
                 501(c)(3) of the Internal Revenue Code of 1986, as amended
                 (the "Code") (or the corresponding provisions of any future
                 United States Revenue Law) and which are not "private
                 foundations" by virtue of being described in Section 509(a) of
                 the Code.  Its principal business address and principal office
                 are located at 4920 Commerce Parkway, Warrensville Heights,
                 Ohio 44128.

                 The Trustees of the Foundation are:  Thomas A. Mann, Diann G.
                 Mann, Richard A. Zellner, Gerald Korngold, Julie Mann Simons,
                 David Mann and William Mann.  The Executive Officers of the
                 Foundation are: Thomas A. Mann (President), Diann G. Mann
                 (Vice President), Richard A. Zellner (Secretary), Gerald
                 Korngold (Treasurer) and Warren Goldenberg (Assistant
                 Secretary).



<PAGE>   6
                                                                    Page 6 of 16



ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATIONS.

         Item 3 is amended and supplemented as follows:

         The Foundation acquired 20,000 shares of Common Stock of the Issuer by
way of a charitable contribution of such shares of Common Stock of the Issuer
from Thomas A. Mann on December 23, 1996.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.

         Item 5 is amended and supplemented as follows:

         (The number of issued and outstanding shares of Common Stock upon
which the various percentages set forth in this amended statement on Schedule
13D are based does not include any outstanding securities convertible into
Common Stock or any shares of Common Stock subject to any outstanding options.)

         (a)     (i)     Thomas A. Mann is the beneficial owner of 247,896
shares of Common Stock, which constitute 3.6% of the 6,931,618 shares of Common
Stock issued and outstanding as of December 6, 1996.

                 (ii)    APVI is the beneficial owner of 93,147 shares of
Common Stock, which constitute 1.3% of the 6,931,618 shares of Common Stock
issued and outstanding as of December 6, 1996.

                 (iii)   As described in Item 2 above, Amherst College ceased
to be a Reporting Person on December 23, 1996.

                 (iv)    As described in Item 2 above, Solway ceased to be a
Reporting Person on December 23, 1996.

                 (v)     As described in Item 2 above, the Partnership ceased
to be a Reporting Person on December 23, 1996.

                 (vi)    The Foundation was the beneficial owner of 20,000
shares of Common Stock, which constituted 0.1% of the 6,931,618 shares of
Common Stock issued and outstanding as of December 6, 1996, but sold all of its
shares of Common Stock between December 23, 1996 and the date of this Amendment
No. 2 to Schedule 13D.

         None of the Related Parties, considered individually, owns
beneficially any shares of Common Stock.  However, the Related Parties may, by
virtue of their respective positions with the Reporting Persons, may be deemed
to own beneficially (as that terms is defined in Rule 13d-3 of the Securities
Exchange Act of 1934, as amended) the shares of Common Stock reported as owned
beneficially by the Reporting Person to which such Related Party is related.

                                *    *    *    *


<PAGE>   7
                                                                    Page 7 of 16




                 (c)     Since the filing of Amendment No. 1 to the Statement
on Schedule 13D on November 14, 1996, the Reporting Persons have effected the
following transactions (the broker for each of these transactions was
Montgomery Securities, Inc.)


<TABLE>
<CAPTION>
                                                                                        No. of
                       Party               Transaction               Date               Shares          Price
                       -----               -----------               ----               ------          -----
                  <S>                         <C>                 <C>                   <C>            <C>    
                  Amherst(1)                   Sale                11/15/96                 500         $ 9.92 
                                                                                                               
                  Thomas A. Mann               Sale                11/19/96              11,000         $10.30 
                                                                                                               
                  APVI                         Sale                11/19/96               5,500         $10.30 

                  The Partnership(1)           Sale                11/19/96                 400         $10.30 
                                                                                                               
                  Solway(1)                    Sale                11/19/96                 600         $10.30 
                                                                                                               
                  Thomas A. Mann               Sale                11/25/96               7,500         $11.69 

                  APVI                         Sale                11/25/96               3,000         $11.69 
                                                                                                               
                  Amherst(1)                   Sale                11/25/96                 804         $11.69 
                                                                                                               
                  The Partnership(1)           Sale                11/25/96                 500         $11.69 

                  Solway(1)                    Sale                11/25/96                 500         $11.69 
                                                                                                               
                  Amherst(1)                   Sale                11/26/96                 260         $11.50 
                                                                                                               
                  The Partnership(1)           Sale                11/26/96                 390         $11.50 

                  Solway(1)                    Sale                11/26/96                 190         $11.50 
                                                                                                               
                  Thomas A. Mann               Sale                11/29/96               7,255         $11.21 
                                                                                                               
                  APVI                         Sale                11/29/96               2,167         $11.2

                  Thomas A. Mann               Sale                12/2/96                9,983         $11.80 
                                                                                                               
                  APVI                         Sale                12/2/96                2,755         $11.80 
                                                                                                               
                  Thomas A. Mann               Sale                12/3/96                8,400         $11.75 

                  APVI                         Sale                12/3/96                3,600         $11.75 
                                                                                                               
                  Amherst(1)                   Sale                12/3/96                2,800         $11.75 
                                                                                                               
                  The Partnership(1)           Sale                12/3/96                2,600         $11.75 
</TABLE>

          ____________________

               1  Each of  Amherst, the  Partnership and Solway  terminated its
          participation in the coordination of possible sales of all or some
          portion of the  Common Stock held by the  Reporting Persons, and
          ceased to be a  Reporting Person, by delivery of a  letter to Thomas
          A. Mann on December 23, 1996  in accordance with the terms of that
          certain Joint Filing  Agreement dated  October 16,  1996 among the
          Reporting Persons.
<PAGE>   8
                                                                    Page 8 of 16


<TABLE>
<CAPTION>
                                                                                        No. of
                       Party                Transaction             Date                Shares          Price
                       -----                -----------             ----                ------          -----
                  <S>                         <C>                 <C>                   <C>            <C>      
                  Solway(1)                    Sale                12/3/96                2,600         $11.75   
                                                                                                                 
                  Thomas A. Mann               Sale                12/4/96                1,300         $11.5625 
                                                                                                                 
                  APVI                         Sale                12/4/96                  500         $11.5625 

                  Amherst(1)                   Sale                12/4/96                  400         $11.5625 
                                                                                                                 
                  The Partnership(1)           Sale                12/4/96                  400         $11.5625 
                                                                                                                 
                  Solway(1)                    Sale                12/4/96                  400         $11.5625 

                  Thomas A. Mann               Sale                12/5/96                2,100         $11.50   
                                                                                                                 
                  APVI                         Sale                12/5/96                  900         $11.50   
                                                                                                                 
                  Amherst(1)                   Sale                12/5/96                  700         $11.50   

                  Solway(1)                    Sale                12/5/96                  650         $11.50   
                                                                                                                 
                  The Partnership(1)           Sale                12/5/96                  650         $11.50   
                                                                                                                 
                  Thomas A. Mann               Sale                12/6/96                1,300         $11.1875 

                  APVI                         Sale                12/6/96                  500         $11.1875 
                                                                                                                 
                  Amherst(1)                   Sale                12/6/96                  400         $11.1875 
                                                                                                                 
                  Solway(1)                    Sale                12/6/96                  400         $11.1875 

                  The Partnership(1)           Sale                12/6/96                  400         $11.1875 
                                                                                                                 
                  Thomas A. Mann               Sale                12/9/96                3,600         $11.1875 
                                                                                                                 
                  APVI                         Sale                12/9/96                1,500         $11.1875 

                  Amherst(1)                   Sale                12/9/96                1,200         $11.1875 
                                                                                                                 
                  Solway(1)                    Sale                12/9/96                1,100         $11.1875 
                                                                                                                 
                  The Partnership(1)           Sale                12/9/96                1,100         $11.1875 

                  Amherst(1)                   Sale                12/10/96                 500         $11.1875 
                                                                                                                 
                  Thomas A. Mann               Sale                12/10/96              10,800         $11.1875 
                                                                                                                 
                  APVI                         Sale                12/10/96               4,200         $11.1875 
                                                                                                                 
                  Thomas A. Mann               Sale                12/12/96               3,600         $11.1875 

                  APVI                         Sale                12/12/96               1,400         $11.1875 
                                                                                                                 
                  Thomas A. Mann               Sale                12/16/96              18,000         $11.5425 
                                                                                                                 
                  APVI                         Sale                12/16/96               7,000         $11.5425 

                  Thomas A. Mann               Sale                12/18/96               7,200         $11.5450 
</TABLE>
<PAGE>   9
                                                                    Page 9 of 16



<TABLE>
<CAPTION>
                                                                                         No. of
                       Party                Transaction              Date                Shares           Price
                       -----                -----------              ----                ------           -----
                  <S>                         <C>                 <C>                   <C>             <C>       
                  APVI                         Sale                12/18/96               2,800          $11.5450  
                                                                                                                   
                  Thomas A. Mann               Sale                12/19/96               3,600          $11.2950  
                                                                                                                   
                  APVI                         Sale                12/19/96               1,400          $11.2950  

                  Thomas A. Mann               Gift(2)             12/23/96              20,000           -------  
                                                                                                                   
                  APVI                         Sale                12/27/96               3,780          $11.3181  
                                                                                                                   
                  The Foundation               Sale                12/27/96               9,720          $11.3181  

                  The Foundation               Sale                1/2/97                 7,560          $11.0867  

                  APVI                         Sale                1/2/97                 2,940          $11.0867  
                                                                                                                   
                  Thomas A. Mann               Sale                1/3/97                 4,480          $11.1363  

                  The Foundation               Sale                1/3/97                 2,720          $11.1363  
                                                                                                                   
                  APVI                         Sale                1/3/97                 2,800          $11.1363  

                  Thomas A. Mann               Sale                1/6/97                21,600          $11.1283

                  APVI                         Sale                1/6/97                 8,400          $11.1283
</TABLE>                                                                      

          ____________________

               2  Thomas  A. Mann made a charitable contribution  of 20,000
          shares of  Common Stock of  the Issuer on December 23,  1996.  No
          broker was involved in the transaction.
<PAGE>   10
                                                                   Page 10 of 16




ITEM 7.  MATERIAL FILED AS EXHIBITS.

                 Item 7. is amended and supplemented as follows:

Exhibit 6        Letters dated December 23, 1996 from each of Amherst College,
                 Solway Investments Limited and Pine Street Partners II to
                 Thomas A. Mann notifying the Reporting Persons of its
                 intention to terminate its participation in the coordination
                 of possible sales of all or some portion of the shares of the
                 Common Stock held by the Reporting Persons and to cease to be
                 a Reporting Person.

Exhibit 7        Letter dated December 23, 1996 from The Thomas A. and Diann G.
                 Mann Foundation to the Reporting Persons agreeing to be bound
                 by the terms of the Joint Filing Agreement dated as of October
                 16, 1996 among the Reporting Persons.

<PAGE>   11
                                                                   Page 11 of 16




                                  SCHEDULE 13D
                                 SIGNATURE PAGE

         After reasonable inquiry and to the best of his knowledge and belief,
the undersigned certifies that the information set forth in this statement is
true, complete and correct.


DATED:  January 7, 1997                           /s/ Thomas A. Mann
                                                  -----------------------------
                                                  Thomas A. Mann, individually


DATED:  January 7, 1997                           A.P. VENTURE I. CORP.

                                                  By:         * 
                                                  -----------------------------
                                                      Robert Paul, President


DATED:  January 7, 1997                           THE THOMAS A. AND DIANN G.
                                                  MANN FOUNDATION


                                                  By: /s/ Thomas A. Mann 
                                                  -----------------------------
                                                      Thomas A. Mann, President





* By: /s/ Thomas A. Mann                    
- -----------------------------------------
      Thomas A. Mann, Attorney-in-Fact


<PAGE>   12
                                                                   Page 12 of 16



                                 EXHIBIT INDEX

<TABLE>       
<CAPTION>       
Exhibit                                    Description                                              Page
<S>           <C>                                                                                  <C>
Exhibit 6     Letters dated December 23, 1996 from each of Amherst College, Solway                   13
              Investments Limited and Pine Street Partners II to Thomas A. Mann notifying 
              the Reporting Persons of its intention to terminate its participation in the 
              coordination of possible sales of all or some portion of the shares of the 
              Common Stock held by the Reporting Persons and to cease to be a Reporting Person.
                                                                                                      

Exhibit 7     Letter dated December 23, 1996 from The Thomas A. and Diann G. Mann                    16
              Foundation to the Reporting Persons agreeing to be bound by the terms of the 
              Joint Filing Agreement dated as of October 16, 1996 among the Reporting Persons.
</TABLE>


<PAGE>   1
                                                                   Page 13 of 16




                                   EXHIBIT 6


                          TRUSTEES OF AMHERST COLLEGE
                            Box 2203, P.O. Box 5000
                             Amherst, MA 01002-5000


                                                               December 23, 1996





Mr. Thomas A. Mann
Thomas A. Mann, Inc.
4920 Commerce Parkway
Warrensville Hts., Ohio 44128

         RE:     NOTICE OF WITHDRAWAL FROM GROUP

Dear Tom:

         Pursuant to the terms of that certain Joint Filing Agreement made as
of the 16th day of October, 1996 by and among the persons identified thereon,
this letter will serve to notify each of the parties to that Agreement that
Amherst College hereby terminates its participation in the manners contemplated
therein.  Its withdrawal from the activities of this group is effective
immediately.

                                          Very truly yours,
                                        

                                          TRUSTEES OF AMHERST
                                          COLLEGE


                                          By: /s/ Sharon G. Siegel            
                                              -------------------------------
                                              Sharon G. Siegel, Treasurer



<PAGE>   2
                                                                   Page 14 of 16




                                   EXHIBIT 6


                           SOLWAY INVESTMENTS LIMITED
                              Tropic Isle Building
                                  P.O. Box 438
                       Road Town, British Virgin Islands


                                                               December 23, 1996





Mr. Thomas A. Mann
Thomas A. Mann, Inc.
4920 Commerce Parkway
Warrensville Hts., Ohio 44128

         RE:     NOTICE OF WITHDRAWAL FROM GROUP

Dear Tom:

         Pursuant to the terms of that certain Joint Filing Agreement made as
of the 16th day of October, 1996 by and among the persons identified thereon,
this letter will serve to notify each of the parties to that Agreement that
Solway Investments Limited hereby terminates its participation in the manners
contemplated therein.  Its withdrawal from the activities of this group is
effective immediately.

                                            Very truly yours,


                                            SOLWAY INVESTMENTS
                                            LIMITED


                                            By: /s/ Bob Bernard                 
                                                -----------------------------
                                                Bob Bernard, Agent


<PAGE>   3
                                                                   Page 15 of 16




                                   EXHIBIT 6


                            PINE STREET PARTNERS II
                               c/o Stern Brothers
                          20 Exchange Street, Floor 33
                               New York, NY 10005


                                                               December 23, 1996





Mr. Thomas A. Mann
Thomas A. Mann, Inc.
4920 Commerce Parkway
Warrensville Hts., Ohio 44128

         RE:     NOTICE OF WITHDRAWAL FROM GROUP

Dear Tom:

         Pursuant to the terms of that certain Joint Filing Agreement made as
of the 16th day of October, 1996 by and among the persons identified thereon,
this letter will serve to notify each of the parties to that Agreement that
Pine Street Partners II hereby terminates its participation in the manners
contemplated therein.  Its withdrawal from the activities of this group is
effective immediately.

                                     Very truly yours,


                                     PINE STREET PARTNERS II


                                     By: /s/ William D. Berghold
                                         --------------------------------
                                         William D. Berghold, General Partner



<PAGE>   1
                                                                   Page 16 of 16



                                   EXHIBIT 7

                   THE THOMAS A. AND DIANN G. MANN FOUNDATION
                             4920 Commerce Parkway
                        Warrensville Heights, Ohio 44128

                                                               December 23, 1996

Mr. Thomas A. Mann                             AP Venture I. Corp.
4920 Commerce Parkway                          c/o Robert Paul
Warrensville Hts., Ohio 44128                  Ampco-Pittsburgh Corporation
                                               600 Grant Street, 46th Floor
                                               Pittsburgh, PA 15219

Gentlemen:

         For good and valuable consideration, the receipt and sufficiency of
which is hereby acknowledged, the undersigned hereby agrees to be bound by the
terms of that certain Joint Filing Agreement dated as of October 16, 1996 among
Thomas A. Mann, Robert A.  Mann, AP Venture I. Corp., The Trustees of Amherst
College, Solway Investments Limited and Pine Street Partners II (the "Group")
pertaining to the statement on Schedule 13D filed on October 16, 1996 filed by
the Group with respect to the Common Stock, $0.01 par value per share, of
Ribozyme Pharmaceuticals, Inc.

                                                Very truly yours,

                                                THE THOMAS A. AND
                                                DIANN G. MANN FOUNDATION

                                                By:   /s/ Thomas A. Mann   
                                                ------------------------------
                                                Thomas A. Mann, President

ACKNOWLEDGED AND AGREED TO:

/s/ Thomas A. Mann                
- --------------------------------
    Thomas A. Mann

    AP VENTURE I. CORP.

By: /s/ Robert Paul                         
- --------------------------------
    Robert Paul, President



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission