CHROMATICS COLOR SCIENCES INTERNATIONAL INC
SC 13D/A, 1997-12-22
LABORATORY ANALYTICAL INSTRUMENTS
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                                                    ----------------------------
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                                                    ----------------------------
                    UNITED STATES                   OMB Number:
       SECURITIES AND EXCHANGE COMMISSION           Expires:
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                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 5 )*


                  CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    171116106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                            Darby Simpson Macfarlane
                               5 East 80th Street
                                 N.Y, N.Y. 10021
                                 (212) 717-6544
- --------------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)


                                October 23, 1997
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1 (b)(3) or (4), check the following box [ ].

     Check the  following  box if a fee is being paid with the statement [ ]. (A
fee is not required only if the reporting person:  (1) has a previous  statement
on file reporting beneficial ownership of more than five percent of the class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                         (continued on following pages)
                              (Page 1 of 9 Pages)
<PAGE>

                                  SCHEDULE 13D

CUSIP NO. 171116106                                Page  2   of   9   Pages
          ---------                                     ---      ---


- --------------------------------------------------------------------------------
1    NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     Darby Simpson Macfarlane   ###-##-####
- --------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*               (a) [ ]
                                                                     (b) [ ]

- --------------------------------------------------------------------------------
3    SEC USE ONLY


- --------------------------------------------------------------------------------
4    SOURCE OF FUNDS*

     OO
- --------------------------------------------------------------------------------
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
     ITEMS 2(d) or 2(e)                                                   [ ]

- --------------------------------------------------------------------------------
6    CITIZENSHIP OR PLACE OR ORGANIZATION

     United States of America
- --------------------------------------------------------------------------------
    NUMBER OF            7    SOLE VOTING POWER

     SHARES                   590,813 (See response to Item 5)
                    ------------------------------------------------------------
  BENEFICIALLY           8    SHARED VOTING POWER

    OWNED BY                  -0-
                    ------------------------------------------------------------
      EACH               9    SOLE DISPOSITIVE POWER

    REPORTING                 590,813 (See response to Item 5)
                    ------------------------------------------------------------
     PERSON              10   SHARED DISPOSITIVE POWER

      WITH                    -0-
- --------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     590,813 (See response to Item 5 and Item 6)
- --------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* [ ]


- --------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     6.4%
- --------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON*

     IN
- --------------------------------------------------------------------------------


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                      INCLUDE BOTH SIDES OF THE COVER PAGE,
                 RESPONSES TO ITEMS 1-7 (INCLUDING EXHIBITS) OF
                  THE SCHEDULE, AND THE SIGNATURE ATTESTATION.

<PAGE>

                                                    ----------------------------
                                                          OMB APPROVAL
                                                    ----------------------------
                    UNITED STATES                   OMB Number:
       SECURITIES AND EXCHANGE COMMISSION           Expires:
              Washington, D.C. 20549                Estimated average burden
                                                    hours per response.......
                                                    ----------------------------

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No.5)*


                  CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    171116106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                            David Kenneth Macfarlane
                               5 East 80th Street
                                N.Y., N.Y. 10021
                                 (212) 717-6544
- --------------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)


                                October 23, 1997
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)



If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1 (b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with the statement [ ]. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                                Page 3 of 9 pages


<PAGE>


                                  SCHEDULE 13D

CUSIP NO. 171116106                               Page  4   of  9  Pages
         -----------                                   ---     ---


- --------------------------------------------------------------------------------
1    NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     David Kenneth Macfarlane  ###-##-####
- --------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                (a) [ ]
                                                                      (b) [ ]

- --------------------------------------------------------------------------------
3    SEC USE ONLY


- --------------------------------------------------------------------------------
4    SOURCE OF FUNDS*

     OO
- --------------------------------------------------------------------------------
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) or 2(e)

- --------------------------------------------------------------------------------
6    CITIZENSHIP OR PLACE OR ORGANIZATION

     South Africa
- --------------------------------------------------------------------------------
    NUMBER OF            7    SOLE VOTING POWER

     SHARES                   -0- (See response to Item 5)
                    ------------------------------------------------------------
  BENEFICIALLY           8    SHARED VOTING POWER

    OWNED BY                  -0-
                    ------------------------------------------------------------
      EACH               9    SOLE DISPOSITIVE POWER

    REPORTING                 -0- (See response to Item 5)
                    ------------------------------------------------------------
     PERSON              10   SHARED DISPOSITIVE POWER

      WITH                    -0-
- --------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     590,813 (See response to Item 5 and Item 6)
- --------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* [ ]


- --------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     6.4%
- --------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON*

     IN
- --------------------------------------------------------------------------------


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                      INCLUDE BOTH SIDES OF THE COVER PAGE,
                 RESPONSES TO ITEMS 1-7 (INCLUDING EXHIBITS) OF
                  THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


<PAGE>



- --------------------------------------------------------------------------------
This  Amendment No. 5 amends the Schedule 13D dated  September 19, 1993 filed by
Mrs.  Darby Simpson  Macfarlane  and Mr. David Kenneth  Macfarlane as amended by
Amendment No.1 thereto as dated December 28, 1993, as amended by Amendment No. 2
thereto as dated July 21, 1994,  as amended by Amendment  No. 3 thereto as dated
March 31, 1995 and as amended by  Amendment  No.4 as dated  February  12,  1996.
- --------------------------------------------------------------------------------

     Item 1. Security and Issuer.

     This statement relates to the common stock, par value $0.001 per share (the
"Common Stock"),  of Chromatics Color Sciences  International,  Inc., a New York
corporation  (the  "Company").  The Company's  principal  executive  offices are
located at 5 East 80th Street, New York, New York 10021.

Item 2.   Identity and Background.

     (a) Pursuant to Rule 13d-1(f)(1)  promulgated under the Securities Exchange
Act of 1934, as amended (the "Exchange  Act"),  this Schedule 13D is being filed
by  Darby  Simpson  Macfarlane  and  David  Kenneth  Macfarlane.  Mrs.  and  Mr.
Macfarlane are making this single, joint filing.

     (b) The address of the principle place of business of the Reporting Persons
is 5 East 80th Street, New York, New York 10021.

     (c)  Mrs.  Macfarlane's  positions  at  the  Company  are  Director,  Chief
Executive  Officer,   Chairman  of  the  Board  and  Assistant  Treasurer.   Mr.
Macfarlane's  positions  at the  Company  are  Director  and Vice  President  of
Research and Development.

     Neither Mrs. Macfarlane nor Mr. Macfarlane has:

     (d) been convicted in a criminal  proceeding  (excluding traffic violations
or similar misdemeanors) or

     (e) been a party to a civil proceeding of a judicial or administrative body
of competent  jurisdiction  and as a result of such proceeding was or is subject
to a  judgment,  decree  or final  order  enjoining  future  violations  of,  or
prohibiting or mandating activities subject to, Federal or State securities laws
or finding any violation with respect to such laws.

Item 3.   Source and Amount of Funds or Other Consideration.

          Not Applicable.

Item 4.   Purpose of Transaction.

          Not Applicable.


                                Page 5 of 9 pages


<PAGE>


Item 5.   Interest in Securities of the Issuer.

     (a) The aggregate  number of shares of Common Stock  beneficially  owned by
Mrs.  and Mr.  Macfarlane  is 590,813  (6.4% of the total shares of Common Stock
outstanding). This amount does not include 1,380,000 shares of Class A Preferred
Stock owned by Mrs.  Macfarlane,  which may be convertible into shares of Common
Stock upon the occurrence of certain events.

     (b) Mrs.  Macfarlane has the sole power to vote or dispose of the ownership
of 590,813 shares of Common Stock.

     Mrs.  Macfarlane also owns and has the sole power to vote or dispose of the
ownership of 1,380,000 shares of redeemable convertible preferred stock.

     (c) The following sales were effected on open market transactions:

     On June 6, 1997,  Mrs.  Macfarlane  sold 10,000 shares of Common Stock at a
price of $7.00 per share. On August 1, 1997, Mrs.  Macfarlane sold 10,000 shares
of Common  Stock at a price of $10.125  per  share.  On August  19,  1997,  Mrs.
Macfarlane  sold 5,000 shares of Common Stock at a price of $11.00 per share. On
August 20, 1997, Mrs. Macfarlane sold 2,500 shares of Common Stock at a price of
$10.75 per share.  On August 20,  1997,  Mrs.  Macfarlane  sold 2,500  shares of
Common Stock at a price of $11.00 per share. On August 20, 1997, Mrs. Macfarlane
sold 5,000 shares of Common Stock at a price of $11.375 per share. On August 20,
1997, Mrs. Macfarlane sold 2,500 shares of Common Stock at a price of $11.25 per
share. On August 20, 1997, Mrs.  Macfarlane sold 2,500 shares of Common Stock at
a price of $11.125 per share.  On August 21, 1997,  Mrs.  Macfarlane  sold 4,000
shares of Common Stock at a price of $11.875 per share. On August 25, 1997, Mrs.
Macfarlane sold 6,000 shares of Common Stock at a price of $11.625 per share. On
August 27, 1997,  Mrs.  Macfarlane sold 10,000 shares of Common Stock at a price
of $11.50 per share. On September 9, 1997, Mrs. Macfarlane sold 10,000 shares of
Common  Stock  at a price of  $12.75  per  share.  On  October  23,  1997,  Mrs.
Macfarlane sold 20,000 shares of Common Stock at a price of $17.75 per share. On
December 9, 1997,  Mrs.  Macfarlane sold 30,000 shares of Common Stock at $15.50
per share.

Item 6.   Contracts, Arrangements, Understandings or Relationships With
          Respect to Securities of The Issuer.

     Pursuant to a Separation  Agreement dated December 13, 1995, Mr. Macfarlane
has given Mrs.  Macfarlane  sole voting power and power of disposition  over all
Common  Stock or options to  acquire  Common  Stock  hereafter  acquired  by Mr.
Macfarlane.  The Separation Agreement,  the Proxy and the Voting Trust Agreement
are hereinafter referred to collectively as the "Agreements."

     Under the  Agreements,  upon sale of any Common Stock or options to acquire
Common  Stock  of  the  Company  by  Mrs.  Macfarlane  or Mr.  Macfarlane,  Mrs.
Macfarlane can elect to allocate  and/or  distribute  specified  portions of the
proceeds  from such sale in specified  amounts to herself and to Mr.  Macfarlane
and/or  to  trusts  established  for her  daughter  and her  step-daughter.  The
specific terms of such allocations and/or

                                Page 6 of 9 pages


<PAGE>


distributions, and the amounts to be so distributed and/or allocated, are as set
forth in Articles  VII and X of the  Separation  Agreement,  copies of which are
available for inspection at the Company's  executive  offices.  The terms of the
Proxy and Voting Trust Agreement are hereby  incorporated by reference as if set
forth in full herein.

Item 7.   Materials Filed as Exhibits.

Exhibit 1: Joint Filing Agreement of Darby Simpson  Macfarlane and David Kenneth
Macfarlane  filed as an exhibit to  Schedule  13D dated  October 26,  1993,  and
hereby incorporated by reference thereto.

Exhibit 2: Voting Proxy dated  December 13, 1995 of David Kenneth  Macfarlane to
Darby Simpson  Macfarlane filed as an exhibit to Schedule 13D dated February 12,
1996, and hereby incorporated by reference thereto.

Exhibit 3: Voting Trust  Agreement dated December 13, 1995 between David Kenneth
Macfarlane  and Darby  Simpson  Macfarlane  (as trustee)  filed as an exhibit to
Schedule  13D dated  February  12, 1996,  and hereby  incorporated  by reference
thereto.

                                Page 7 of 9 pages


<PAGE>


                                    SIGNATURE

         After  reasonable  inquiry and to the best of her or his  knowledge and
belief, each of the undersigned certifies that the information set forth in this
statement is true, complete and correct.

Dated:    December 22, 1997

                                             /s/ Darby S. Macfarlane
                                             -----------------------
                                             Darby S. Macfarlane




                                             /s/ David Kenneth Macfarlane
                                             ----------------------------
                                             David Kenneth Macfarlane


                                Page 8 of 9 pages


<PAGE>


                                  EXHIBIT INDEX


Exhibit 1 --   Joint Filing Agreement of Darby Simpson Macfarlane and David 
               Kenneth Macfarlane filed as an exhibit to Schedule 13D dated 
               October 26, 1993, and hereby incorporated by reference thereto.

Exhibit 2 --   Voting  Proxy dated  December  13, 1995 of David  Kenneth
               Macfarlane to Darby Simpson  Macfarlane filed as an exhibit to
               Schedule 13D dated February 12, 1996, and hereby  incorporated
               by reference thereto.

Exhibit 3 --   Voting Trust Agreement dated December 13, 1995 between David
               Kenneth Macfarlane and Darby Simpson Macfarlane (as trustee) 
               filed as an exhibit to Schedule 13D dated February 12, 1996,
               and hereby incorporated by reference thereto.

                                Page 9 of 9 pages




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