CHROMATICS COLOR SCIENCES INTERNATIONAL INC
S-3/A, 2000-01-28
LABORATORY ANALYTICAL INSTRUMENTS
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    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 28, 2000


                                                      REGISTRATION NO. 333-82071
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- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------


                                AMENDMENT NO. 6
                                       TO
                                    FORM S-3

                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                            ------------------------
                 CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)


<TABLE>
<S>                                     <C>
                NEW YORK                               13-3253392
        (STATE OF INCORPORATION)          (I.R.S. EMPLOYER IDENTIFICATION NO.)
</TABLE>

                            ------------------------
                               5 EAST 80TH STREET
                               NEW YORK, NY 10021
                                 (212) 717-6544
  (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                   REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------

                               WITH A COPY TO:

              ARBY S. MACFARLANE        JEFFREY E. LAGUEUX, ESQ.
            CHAIRPERSON OF THE BOARD    PATTERSON, BELKNAP, WEBB &
                      AND                      TYLER LLP
            CHIEF EXECUTIVE OFFICER       1133 AVENUE OF THE
               5 EAST 80TH STREET               AMERICAS
               NEW YORK, NY 10021       NEW YORK, NY 10036-6710
                  (212) 717-6544             (212) 336-2000

                      (ADDRESS, INCLUDING ZIP CODE, AND
                    TELEPHONE NUMBER, INCLUDING AREA CODE,
                            OF AGENT FOR SERVICE)

                            ------------------------

     APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: AS SOON AS
PRACTICABLE AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.

     If the only securities being registered on this form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. / /

     If any of the securities being registered on this form are being offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. / /

     If this form is filed to register additional securities pursuant to
Rule 462(b) under the Securities Act of 1933, please check the following box and
list the Securities Act of 1933 registration statement number of the earlier
effective registration statement for the same offering. / /

     If this form is a post-effective amendment filed pursuant to
Rule 462(c) under the Securities Act of 1933, check the following box and list
the Securities Act of 1933 registration statement number of the earlier
effective registration statement for the same offering. / /

     If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
                            ------------------------

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
                                                 PROPOSED MAXIMUM    PROPOSED MAXIMUM         AMOUNT OF
  TITLE OF SHARES TO BE        AMOUNT TO BE       OFFERING PRICE    AGGREGATE OFFERING      REGISTRATION
       REGISTERED             REGISTERED(1)        PER SHARE(2)          PRICE(2)              FEE(3)
<S>                        <C>                   <C>                <C>                   <C>
Common Stock, par value
$.001                        1,845,403 shares         $8.4375         $15,570,587.81          $7,603.06
</TABLE>

(1) Represents the total shares of common stock (i) issuable upon conversion of
    14% senior convertible debentures issued by Registrant in the principal
    amount of $5 million on April 15, 1999 (1,000,000 shares) at a conversion
    price of $5.00; (ii) issuable upon conversion of 40,000 shares of
    convertible preferred stock issued by Registrant for aggregate proceeds of
    $4 million on June 15, 1999 (574,713 shares); and (iii) issuable upon the
    exercise of 270,690 warrants issued by Registrant on June 15, 1999 at an
    exercise price of $7.92 per share.

(2) Estimated solely for the purpose of calculating the registration fee. These
    estimates have been calculated in accordance with Rule 457(c) under the
    Securities Act of 1933 and are based upon the average of the high and low
    prices per share of the Registrant's common stock on the Nasdaq SmallCap
    Market on June 28, 1999.

(3) Paid on June 30, 1999.
                            ------------------------

     THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(a),
MAY DETERMINE.
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- --------------------------------------------------------------------------------
<PAGE>



PROSPECTUS


                           CHROMATICS COLOR SCIENCES
                              INTERNATIONAL, INC.

                        1,845,403 SHARES OF COMMON STOCK

The selling stockholders named in this prospectus are offering and selling
shares of our common stock. These shares were acquired by the selling
stockholders upon the exercise of convertible debt securities, convertible
preferred stock and warrants sold by us to the selling stockholders in private
financings.

The selling stockholders may sell the shares of common stock described in this
prospectus in a number of different ways. The prices at which the selling
stockholders may sell the shares of common stock will be determined by
prevailing market prices for the shares or by negotiated transactions. We will
not receive any of the proceeds from the sale of shares, but we will receive the
exercise price of the warrants.


Our common stock is listed on the Nasdaq SmallCap Market under the symbol
"CCSI." On January 24, 2000 the closing sales price of our common stock on the
Nasdaq SmallCap Market was $7.6875.


YOU SHOULD READ THE DESCRIPTION OF RISKS UNDER THE CAPTION "RISK FACTORS"
BEGINNING ON PAGE 4 BEFORE PURCHASING ANY OF THE COMMON STOCK OFFERED BY THIS
PROSPECTUS.

The shares offered or sold under this prospectus have not been approved or
disapproved by the Securities and Exchange Commission or any state securities
commission, nor have these organizations determined that this prospectus is
accurate or complete. Any representation to the contrary is a criminal offense.


                The date of this prospectus is January 28, 2000.


The information contained in this prospectus is not complete and may be changed.
These securities may not be sold until the Registration Statement filed with the
Securities and Exchange Commission
is effective. This prospectus is not an offer to sell these securities and is
not soliciting an offer to buy these securities in any State where the offer or
sale is not permitted.
<PAGE>
                            SUMMARY OF THE OFFERING

     We are engaged in the business of researching, developing and
commercializing intellectual property rights, technology and instrumentation we
have developed in the field of color science. Color science involves the
objective, standardized analysis, description and measurement by instrument to a
laboratory standard of accuracy of the colors composing the visual color
spectrum and their related physical properties in relation to each other.

     We have incorporated some of these intellectual property rights, technology
and instrumentation into a proprietary color measurement system and software
marketed for various applications known as the ColorMate(R) System. We have
developed our intellectual property and the ColorMate(R) System for:

      o the color measurement to a laboratory standard of accuracy and
        classification of human tissue, fluid, hair and/or teeth color,

      o the color coordination of these human skin, tissue, fluid, hair and/or
        teeth color classifications in relation to products.

      o the color measurement to a laboratory standard of accuracy,
        classification and organization based on color of various
        color-sensitive consumer products including chromaticity studies of
        cosmetics, hair coloring, hosiery, clothing, tooth enamel, paint and
        textiles,

      o the color measurement to a laboratory standard of accuracy to monitor
        infant jaundice,

      o the color measurement in detecting and monitoring those diseases which
        we believe can be diagnosed or monitored by the coloration of human
        skin, tissue and fluids and

      o the color coordination of products in relation to other products.

     In July 1997 we received clearance from the U.S. Food and Drug
Administration for commercial marketing of our ColorMate(R) System device for
the non-invasive monitoring of infant jaundice by healthcare professionals in
the hospital, institutional, pediatricians' office or home setting. In June 1999
we entered into an agreement for the exclusive distribution of this product in
the hospital, pediatricians' office and home healthcare markets in the United
States with Datex-Ohmeda, Inc. and its Ohmeda Medical Division. The current
procedure for the initial screening for infant jaundice is the visual
observation of the yellowing of the skin by professional care providers. This is
a subjective determination prone to errors due to different skin colors. If the
initial clinical assessment suggests the possibility of infant jaundice, the
current procedure requires that a blood sample be obtained by lancing the
infant. We believe that a non-invasive instrument that monitors infant jaundice
represents a significant improvement in patient care.

     The ColorMate(R) TLc-BiliTest(R) System monitors the incremental change of
the yellow content of the skin color in infants of all races by non-invasively
measuring the color of the skin of the newborn. Color measurements are obtained
by placing the device on different physical sites of the newborn for five to ten
seconds. Accuracy of the color measurements is ensured by use of the
TLc-Lensette(TM) calibration standard used prior to each baby's measurement.

     We are currently in the early stages of the commercialization of our
ColorMate(R) TLc-BiliTest(R) System for the monitoring of infant jaundice. We
will need to generate substantial revenues from the sale of our products and the
financial markets in order to develop other medical and non-medical applications
for our intellectual property rights, technology and instrumentation and to fund
our continuing operations. If we are not successful in generating adequate
revenues, we may be forced to curtail our operations and seek protection from
our creditors under applicable bankruptcy laws.

     In order to finance our activities, we recently completed two private
placements of securities with the selling stockholders. In April 1999 we sold
$5 million in principal amount of 14% senior convertible debentures and in June
1999 we sold 40,000 shares of convertible preferred stock and warrants to
purchase 220,690 shares of our common stock for aggregate proceeds of
$4 million. All of these securities are convertible into shares of our common
stock at the option of their holders at specified prices. The conversion price
of the senior convertible debentures is $5.00. The conversion price of the
convertible preferred stock is $6.96. The exercise price of the warrants is
$7.92. All of these securities are subject to mandatory conversion

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if the average trading price of our common stock equals or exceeds specified
prices in the future. These prices are $10.29 for the convertible debentures,
$10.88 for the convertible preferred stock and $16.50 for the warrants. In
addition, the conversion price of the convertible preferred stock is subject to
downward adjustment if we issue additional shares of our common stock at less
than $6.96 per share. If not sooner converted, the senior convertible debentures
mature on April 15, 2002. The convertible preferred stock is redeemable at $115
per share on June 15, 2002. We have the option to extend this redemption date to
June 15, 2004. The warrants expire on June 15, 2004. The shares of common stock
into which these securities are convertible are the subject of this prospectus.

     We were incorporated in New York in March 1984. Our principal executive
offices are located at 5 East 80th Street, New York, New York 10021 and our
telephone number at that address is (212) 717-6544.

                                       3
<PAGE>
                                  RISK FACTORS

     Investing in our common stock is very risky. You should be able to bear a
complete loss of your investment. You should carefully consider the following
factors, in addition to the other information in this prospectus, before
investing in our common stock.

WE HAVE A LIMITED OPERATING HISTORY

     We have a limited operating history and have generated insignificant
revenues to date. Although we have recently entered into agreements for the
manufacturing and distributing of our ColorMate(R) TLc-BiliTest(R) System, to
date we have not produced or sold substantial quantities of this product. We
cannot assure you that this product can be manufactured in commercial quantities
or at an acceptable cost or marketed successfully. We also cannot assure you
that we will be successful in our efforts to commercialize our ColorMate(R)
System for other applications.

WE EXPECT TO CONTINUE TO OPERATE AT A LOSS AND WE MAY NEVER ACHIEVE
PROFITABILITY

     We cannot be certain that we will ever achieve and sustain profitability.
To date, we have been engaged in research and development activities and have
not generated any significant revenues from product sales. As of September 30,
1999, we had an accumulated deficit of $30,890,300. We expect that we will
continue to incur operating losses for the current and subsequent fiscal years.

     In addition, we will record the following charges in connection with the
$5.0 million debt financing in April 1999 and $4.0 million preferred stock
financing in June 1999.

          o The April financing will result in an additional interest charge of
            approximately $3.5 million, resulting from a below-market conversion
            price of the debt. This amount will be expensed over the
            twelve-month period ending April 2000.

          o The June financing will result in a deemed dividend charge of
            approximately $3.0 million, resulting from a below-market conversion
            price of the preferred stock, a redemption premium and warrants
            issued in connection with the financing. Of this amount,
            $1.2 million was charged in June 1999 and $1.8 million will be
            charged over the redemption period.

IF WE DO NOT SECURE ADDITIONAL FINANCING WE WILL NOT BE ABLE TO DEVELOP AND
MARKET OUR PRODUCTS

     We will require substantial additional funds for our research and product
development programs, for contractual obligations, for operating expenses, to
pursue regulatory approvals and to develop and commercialize other applications
of our ColorMate(R) System. Adequate funds for these purposes, whether through
the financial markets or other sources, may not be available when needed.
Additionally, under the terms of our manufacturing agreement we must provide our
manufacturing partner with a number of key component parts to be assembled into
our ColorMate(R) System and our ColorMate(R) TLc-BiliTest(R) System. Without the
funds to provide these component parts, our products cannot be manufactured and
we will be unable to fulfill our obligations to our distrtibution partner. The
terms of the convertible preferred stock that require a downward adjustment in
the conversion price if we issue shares of common stock at a price of less than
$6.96 per share will increase the cost to us of any subsequent equity financing
effected at less than $6.96 per share. If we fail to make any payment required
or if we are otherwise in default under the manufacturing and distribution
agreements relating to our ColorMate(R) System and our ColorMate(R) TLc-
BiliTest(R) System, the other parties will have the right to terminate the
agreements. Termination of any of these agreements would have a material adverse
effect on our business by rendering us unable to manufacture and distribute our
ColorMate(R) System and our ColorMate(R) TLc-BiliTest(R) System until
replacement agreements were entered into.

WE WILL REQUIRE ADDITIONAL FUNDS IF THE CONVERTIBLE DEBENTURES AND CONVERTIBLE
PREFERRED STOCK ARE NOT CONVERTED PRIOR TO MATURITY

     We will be obligated to repay the selling stockholders $7,100,000 in cash
on the April 15, 2002 maturity date of the convertible debentures and $4,600,000
on the June 15, 2002 redemption date of the convertible preferred stock unless
they elect to convert or we are able to compel conversion. The redemption date
of the convertible preferred stock may be postponed at our option until
June 15, 2004 subject to the accrual of a 8% dividend after June 15, 2002 which
will increase the total redemption amount to $5,240,000. The selling

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<PAGE>
stockholders generally will not elect to convert the convertible debentures
unless the market price of our common stock exceeds $5.00 per share at the time
of conversion. Similarly, the selling stockholders generally will not elect to
convert the convertible preferred stock unless the market price of our common
stock exceeds $6.96 per share at the time of conversion. In addition, if an
event of default occurs with respect to the convertible debentures prior to the
stated maturity date the selling stockholders may elect to accelerate the
maturity of the convertible debentures with the effect that the principal amount
and all accrued but unpaid interest would become immediately due and payable. We
cannot assure you that we would have sufficient funds available to us to satisfy
these obligations. Failure to satisfy these obligations would have a material
adverse effect on our business and could force us to close our operations and
seek protection from our creditors under applicable bankruptcy laws.

WE DO NOT HAVE MANUFACTURING OR MARKETING CAPABILITIES OF OUR OWN AND DEPEND ON
OTHER PARTIES FOR MANUFACTURING AND MARKETING

     We currently do not have the resources to manufacture or market
independently on a commercial scale the ColorMate(R) System, the ColorMate(R)
TLc-BiliTest(R) System or any other products that we may develop. We rely on our
corporate partners to manufacture and to market our ColorMate(R) TLc-BiliTest(R)
System and will continue to rely on corporate partners to manufacture and to
market our ColorMate(R) System for other applications. The amount and timing of
resources to be devoted to these activities by these other parties may not be
within our control. We cannot assure you that these parties will perform their
obligations as expected or that we will derive any revenue from these
arrangements. We have no experience in manufacturing or marketing any products.
The failure of our corporate partners to perform their obligations relating to
the manufacturing and distributing of our ColorMate(R) System or ColorMate(R)
TLc-BiliTest(R) System would have a material adverse effect on our business by
rendering us unable to manufacture and distribute our ColorMate(R) System and
our ColorMate(R) TLc-BiliTest(R) System until a replacement arrangement was
entered into.

WE MAY NOT BE SUCCESSFUL IN COMMERCIALIZING OUR COLORMATE(R) TLC-BILITEST(R)
SYSTEM

     Our success in commercializing our ColorMate(R) TLc-BiliTest(R) System will
be dependent upon its acceptance by healthcare professionals. Their acceptance
will largely depend on our ability to show them its ability to reduce the need
for heelsticks in monitoring infant jaundice as well as its utility compared to
other non-invasive methods that currently exist or that may be developed in the
future by others with respect to:

          o safety,

          o effectiveness,

          o ease of use and

          o price.

     We cannot assure that our ColorMate(R) TLc-BiliTest(R) System will be
competitive with respect to these factors.

WE HAVE NOT YET SUCCESSFULLY COMMERCIALIZED OUR COLORMATE(R) SYSTEM FOR OTHER
POTENTIAL MEDICAL APPLICATIONS

     Although we have received FDA clearance to commercially market our
ColorMate(R) TLc-BiliTest(R) System for monitoring infant jaundice, our clinical
and research development programs for other medical applications of our
ColorMate(R) System are at a very preliminary stage. Substantial additional
research and development and further clinical trials will be necessary before
commercial versions of any additional proposed products are submitted for FDA
marketing clearance or approval and produced for other medical applications. We
cannot assure you that we will be able to successfully address the problems that
may arise during the development, FDA review process and commercialization of
these other medical applications or that any of our proposed products for these
other medical applications will be successfully developed, proven safe and
effective in clinical trials, cleared or approved by the FDA for marketing or
meet applicable regulatory standards and requirements.

                                       5
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WE HAVE NOT YET SUCCESSFULLY COMMERCIALIZED OUR COLORMATE(R) SYSTEM FOR
NON-MEDICAL APPLICATIONS

     To date, we have not achieved commercial market penetration in any
non-medical industry. In order to commercialize our ColorMate(R) System in
connection with non-medical applications we will need to develop additional
marketing skills, incur significant expenses on sales and marketing activities,
hire additional employees and consultants and enter into arrangements with third
party distributors. We cannot assure you that we will be successful in our
efforts to commercialize any of these non-medical applications of our
ColorMate(R) System.

EXTENSIVE GOVERNMENTAL REGULATION COULD DELAY, RESTRICT OR PREVENT THE MARKETING
OF OUR PRODUCTS

     Governmental regulation may significantly delay the marketing of our
products, prevent marketing of products altogether or impose costly requirements
on our activities. The FDA and comparable foreign regulatory authorities
generally require rigorous pre-clinical testing, clinical trials and government
premarket review and clearance or approval for the type of human medical device
we market or contemplate marketing. Numerous regulations govern, among other
things, the manufacturing, safety, labeling, promotion, storage, record keeping,
reporting and marketing of medical devices. A delay in obtaining or failure to
obtain or maintain regulatory clearances or approvals for any of our products
would have an adverse effect on our business. We cannot predict the adverse
effects that existing or future government regulations may have on our business.

     Even though our ColorMate(R) TLc-BiliTest(R) System received FDA marketing
clearance for monitoring infant jaundice, we may still face difficulties in
manufacturing and marketing this product. A marketed product and its
manufacturer's practices are subject to regulatory review and the manufacturer's
facilities are subject to periodic establishment inspections. The discovery of
previously unknown problems with a product, manufacturer or facility may result
in restrictions on the product or manufacturer, including withdrawal of the
product from the market. The failure to comply with applicable regulatory
requirements can, among other things, result in:

          o fines,

          o suspended or withdrawn regulatory approvals,

          o refusal to clear or approve pending applications,

          o refusal to permit exports or to allow imports from the United
            States,

          o product recalls,

          o seizure of products,

          o injunctions,

          o operating restrictions and

          o criminal prosecutions.

WE MAY BE UNABLE TO DEVELOP POTENTIAL INTERNATIONAL MARKETS AND OBTAIN FOREIGN
REGULATORY APPROVALS

     Although we believe that sales of our products to customers outside of the
United States represent a significant potential source of growth we may not be
able to obtain agreements with third party distributors for marketing outside of
the United States. We also cannot be certain that we will be able to maintain
our existing ISO 9001/EN46001 certification or that we will obtain any further
regulatory approvals in other countries. In order to market our products outside
of the United States, we must comply with numerous and varying foreign
regulatory requirements implemented by foreign authorities. The approval
procedure varies among countries and can involve additional testing. The time
required to obtain further foreign clearances or approvals may differ from that
required to obtain FDA clearances or approvals for commercial marketing. The
foreign regulatory approval process includes all of the risks associated with
obtaining FDA clearances or approvals set forth above, and clearance or approval
by the FDA does not ensure clearance or approval by the authorities of any other
country.

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<PAGE>
THE MEDICAL COMMUNITY MAY BE RELUCTANT TO ACCEPT OUR TECHNOLOGY

     The commercial acceptance of our ColorMate(R) TLc-BiliTest(R) System is
substantially dependent on its acceptance by the medical community for the
monitoring of infant jaundice. Because the medical community is relatively slow
to adopt new technologies we cannot assure you that the medical community will
perceive a need for, or accept, our ColorMate(R) TLc-BiliTest(R) System or be
willing to commit funds to its purchase and use. Widespread acceptance of the
ColorMate(R) TLc-BiliTest(R) System for monitoring infant jaundice will require
educating the medical community about its advantages, reliability, cost-
effectiveness and utility. In addition, acceptance of the ColorMate(R)
TLc-BiliTest(R) System may be adversely affected by competing products which may
have more utility, a lower cost or be received in a better way than our
ColorMate(R) TLc-BiliTest(R) System.

OUR MAIN COMPETITORS GENERALLY HAVE MORE RESOURCES THAN WE HAVE

     The medical device industry is characterized by rapid technological
advances, evolving industry standards and technological obsolescence. Our
inability to meet or surpass our competitors' technological advances in this
industry could have a material adverse effect on our business. We have several
competitors in this industry, none of whom we believe to be dominant. We believe
that, in addition to our ColorMate(R) TLc-BiliTest(R) System the only other
commercially available non-invasive devices for the monitoring of infant
jaundice with FDA marketing clearance in the United States are the Minolta
Jaundice Meter, manufactured by Minolta Co., Ltd. which is distributed by Air
Shields and the SpectRx Bilicheck, manufactured by SpectRx and Respironics. Both
Minolta and Respironics have financial, marketing and other resources greater
than our own. Our competitors in this industry may develop products which may
render our ColorMate(R) TLc-BiliTest(R) System obsolete or which have advantages
over our ColorMate(R) TLc-BiliTest(R) System, including greater accuracy and
precision or greater acceptance by the medical community.

     To the extent that we are able to commercialize our ColorMate(R) System for
non-medical applications we will also encounter competition. We cannot assure
you that we will be able to compete successfully in these non-medical markets.

OUR BOARD OF DIRECTORS IS AUTHORIZED TO ISSUE PREFERRED STOCK WITHOUT
STOCKHOLDER AUTHORIZATION WHICH COULD BE USED AS AN ANTI-TAKEOVER DEVICE

     Our Board of Directors is authorized to issue from time to time without
stockholder authorization shares of preferred stock. The issuance of preferred
stock could decrease the amount of assets and earnings available for
distribution to our other stockholders. Preferred stockholders could receive
voting rights and rights to payments on liquidation or of dividends or other
rights which are greater than the rights of the holders of our common stock. In
addition, the issuance of preferred stock may make it more difficult for a third
party to acquire, or may discourage a third party from acquiring, voting control
of our stock. This provision could also discourage an unsolicited acquisition
and could make it less likely that stockholders receive a premium for their
shares as a result of any unsolicited acquisition proposal.

OUR DIRECTORS AND EXECUTIVE OFFICERS OWN A SIGNIFICANT AMOUNT OF STOCK OF
CHROMATICS AND EXERT CONSIDERABLE CONTROL OVER CHROMATICS

     As of December 1, 1999, our directors and executive officers beneficially
owned approximately 18.5% of voting power represented by our outstanding common
and preferred stock. As a result, these stockholders are able to significantly
influence all matters requiring stockholder approval, including the election of
directors and the approval of significant corporate transactions. This
concentration of ownership could also delay or prevent a change in control that
may be favored by other stockholders.

WE WILL NEED TO HIRE ADDITIONAL PERSONNEL TO MANAGE OUR TRANSITION FROM A
DEVELOPMENT STAGE COMPANY TO AN OPERATING COMPANY

     In order to generate and service sales of our medical products we will need
to attract and retain significant additional senior and midlevel personnel
experienced in financial, administrative, marketing, sales and regulatory
matters in the medical industry. We currently only have 37 full-time employees,
of which 18 are medical marketing or regulatory personnel. Our success will
depend in part on our ability to hire, train and retain new and existing
personnel. Competition for qualified personnel is intense and we cannot assure

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you that we will be successful in hiring, training or retaining additional
personnel to support our executive, operations, marketing, sales, research and
product development needs and efforts.

WE DEPEND ON THE SERVICES OF KEY PERSONNEL

     Our success depends to a significant extent upon the efforts of Darby
Simpson Macfarlane, the Chairperson of our Board of Directors, our Chief
Executive Officer and one of our major stockholders, and David Kenneth
Macfarlane, our Vice President, Research and Development. They are co-inventors
of our ColorMate(R) System and possess unique technical knowledge required in
connection with its production. Although we have purchased key-man life
insurance policies in the amounts of $1,000,000 on the lives of each of Ms. and
Mr. Macfarlane, we cannot assure you that the proceeds from these policies would
enable us to retain suitable replacements for them. The loss of the services of
either Ms. Macfarlane or Mr. Macfarlane could adversely affect our business.

WE ARE A DEFENDANT IN PENDING SECURITIES LITIGATION AND EXPECT TO INCUR
SUBSTANTIAL EXPENSES IN CONNECTION WITH OUR DEFENSE AND COUNTERCLAIMS

     We have been named, together with five of our officers and directors, as a
defendant in three pending legal actions involving allegations that we made
false and misleading statements during the period from July 30, 1997 through
June 8, 1998 regarding:

          o the new innovative nature of our ColorMate(R) TLc-BiliTest(R)
            System,

          o the market size and revenue potential of our ColorMate(R)
            TLc-BiliTest(R) System and

          o the existence and status of negotiations with potential distributors
            of our ColorMate(R) TLc-BiliTest(R) System.

     Although we believe that the claims asserted in these suits are without
merit and intend to contest them vigorously, we expect to incur substantial
legal expenses in connection with defending these actions and pursuing our
counterclaims and cannot assure you that the outcome of this litigation will not
have a material adverse effect on our business.

WE FACE THE RISK OF PRODUCT LIABILITY CLAIMS WHICH MAY EXCEED THE SCOPE OR
AMOUNT OF OUR INSURANCE COVERAGE

     The manufacture and sale of human medical devices entails significant risk
of product liability claims. In determining the amount of product liability
coverage to obtain we were advised by an insurance broker with knowledge and
experience regarding prevailing insurance practices in the medical device
industry. Although we believe that the amount and scope of coverage obtained is
consistent with prevailing medical device industry practice, we cannot assure
you that our product liability coverage will be adequate to protect us from any
liabilities we might incur in connection with the use or sale of our products.
In addition, we may require increased product liability coverage as additional
products are commercialized. Product liability insurance is expensive and in the
future may not be available on acceptable terms, if at all. A successful product
liability claim or series of claims brought against us in excess of our
insurance coverage could have a material adverse effect on our business and
results of operations. We must indemnify our distribution partner against any
product liability claims brought against it arising out of products developed by
us.

OUR SUCCESS IS DEPENDENT UPON OUR ABILITY TO EFFECTIVELY MAINTAIN OUR PATENTS
AND PROPRIETARY RIGHTS RELATING TO OUR COLORMATE(R) SYSTEM AND OUR COLORMATE(R)
TLC-BILITEST(R) SYSTEM, WHICH WE MAY NOT BE ABLE TO DO

     Proprietary technology maintained in our trade secrets and other
proprietary information claimed by our patents is incorporated into the
proprietary software and measurement system used in our ColorMate(R) System, our
ColorMate(R) TLc-BiliTest(R) System and our TLc-Lensette(TM) calibration
standards. Because we are dependent on the commercialization of these products
our success will depend to a significant degree on our ability to preserve our
trade secrets, to obtain and maintain our patents and to operate without
infringing the proprietary rights of others. We cannot assure you that our
competitors will not seek to apply for and obtain patents that prevent, limit or
interfere with our ability to make, use and sell our products either in the
United States or in foreign countries. We also cannot assure you that we will
not become subject to patent

                                       8
<PAGE>
infringement claims brought by third parties or to re-examination of previously
issued patents or interference proceedings to determine the priority of
inventions.

     We also rely on a combination of trade secret and copyright law, employee
and third-party nondisclosure agreements and other protective measures to
protect intellectual property rights pertaining to our products and
technologies. We cannot be certain that these measures will provide protection
of our proprietary information. In addition, the laws of a small number of
foreign jurisdictions may not protect our intellectual property rights to the
same extent as the laws of the United States.

OUR ASSUMPTIONS REGARDING THE BUSINESS PLAN AND STRATEGY FOR OUR COLORMATE(R)
TLC-BILITEST(R) SYSTEM MAY PROVE TO BE INACCURATE

     Our business plan and strategy for the commercialization of our
ColorMate(R) TLc-BiliTest(R) System is based upon assumptions made by our
distribution partner in our contract regarding the size of the infant jaundice
monitoring market, our short-term and eventual share of this market, the price
at which we believe we will be able to sell or lease this product and consumer
acceptance of this product. We cannot assure you that these assumptions will
prove to be correct. The medical community has thus far not used a non-invasive
device for monitoring infant jaundice as a standard of care. Assumptions made by
our distribution partner about the size of the existing market were based on the
current standard of care (an invasive blood test) and, accordingly, there can be
no assurance that the market size of the ColorMate(R) TLc-BiliTest(R) System
will be the same.

OUR STOCK PRICE COULD BE ADVERSELY AFFECTED IF WE WERE DELISTED FROM THE NASDAQ
SMALLCAP MARKET

     Our common stock is presently traded on the Nasdaq SmallCap Market. If we
fail to meet the Nasdaq SmallCap Market listing requirements and our common
stock was delisted the market value of our common stock could fall and holders
of common stock would likely find it more difficult to dispose of and to obtain
accurate quotations as to the market value of our common stock. If our common
stock is delisted from the Nasdaq SmallCap Market it could become subject to
rules adopted by the SEC regulating broker-dealer practices in connection with
transactions in "penny stocks." The penny stock rules require a broker-dealer
prior to a transaction in a penny stock not otherwise exempt from the rules to
deliver a standardized risk disclosure document which provides information about
penny stocks and the nature and level of risks in the penny stock market.

     These disclosure requirements may have the effect of reducing the level of
trading activity in the secondary market for a stock that becomes subject to
these penny stock rules. If our common stock becomes subject to the penny stock
rules, you may be unable to readily sell shares of our common stock.

OUR STOCK PRICE MAY BE VOLATILE

     The market price of our common stock has historically been volatile as a
result of:

          o analyst recommendations,

          o announcements of technological innovations or new commercial
            products by us or our competitors,

          o market conditions relating to the medical device industry,

          o sales of substantial amounts of our common stock by existing
            stockholders, including short sales,

          o adverse publicity related to accusations by short sellers and

          o obtaining regulatory clearances in both the U.S. and in foreign
            countries.

     A short sale involves the sale of borrowed shares with the expectation that
the market price of the security will decline in the future. If the anticipated
price decline occurs the short seller replaces the borrowed securities with
shares bought in the market at the lower price and realizes a profit equal to
the difference between the price at which the borrowed shares were sold and the
price at which the replacement shares are purchased. From time to time in the
past concentrated periods of short selling of our common stock have created an
imbalance between the number of shares offered to the market for sale and the
willingness of the market to absorb these shares at prevailing price levels
which has resulted in rapid and substantial declines in the market price of our
common stock.

                                       9
<PAGE>
CONVERSION OF THE CONVERTIBLE DEBENTURES AND THE CONVERTIBLE PREFERRED STOCK AND
EXERCISE OF THE RELATED WARRANTS WILL DILUTE THE INTERESTS OF EXISTING
STOCKHOLDERS

     The conversion price of the convertible debentures and the convertible
preferred stock issued to the selling stockholders and the exercise price of the
related warrants issued to one of the selling stockholders is expected to be
less than the current market price of our common stock on the date of conversion
or exercise. So long as these securities remain outstanding and unconverted or
unexercised, the terms under which we could obtain additional equity financing
may be adversely affected. To the extent of any conversion or exercise of these
securities, the interests of our existing stockholders will be diluted
proportionately.

COST CONTAINMENT RELATING TO HEALTHCARE REFORM COULD ADVERSELY AFFECT OUR
BUSINESS

     Political, economic and regulatory influences are subjecting the healthcare
industry in the United States to fundamental change and are increasing
cost-containment efforts. We anticipate that Congress, state legislatures and
the private sector will continue to review and assess alternative benefits,
controls on healthcare spending through limitations on the growth of private
health insurance premiums and Medicare and Medicaid spending, the creation of
large insurance purchasing groups, price controls on pharmaceuticals and medical
devices and other fundamental changes to the healthcare delivery system. Any
changes of this nature could negatively impact our ultimate profitability. Also,
the trend toward managed healthcare in the United States and the concurrent
growth of organizations like healthcare management organizations, which could
control or significantly influence the purchase of healthcare services and
products, may result in lower prices for our medical product candidates than we
currently expect. We cannot predict what impact the adoption of any federal or
state healthcare reform measures or future private sector reforms may have on
our business.

OUR PRODUCTS MUST BE ACCEPTED FOR REIMBURSEMENT BY THIRD-PARTY PAYORS

     Our ability to successfully commercialize our ColorMate(R) TLc-BiliTest(R)
System and our other medical product candidates will depend in part on the
extent to which appropriate reimbursement codes and authorized cost
reimbursement levels of our products and related treatment are obtained from
governmental authorities, private health insurers and other organizations, like
health maintenance organizations. Third-party payors are increasingly
challenging the prices charged for medical products and services. American
Medical Association CPT codes are generally used to facilitate the processing of
insurance reimbursement claims and to provide a simplified reporting procedure.
However, assignment of a code does not assure that the insurer will provide
reimbursement or that the AMA endorses the medical procedure at issue. In March
1998, we were assigned AMA CPT Code 82250 for processing claims for use of the
ColorMate(R) TLc-BiliTest(R) System. This same code is assigned for the
reimbursement of laboratory blood tests currently used to monitor infant
jaundice. Subsequently, the AMA informed us that CPT Code 84999, not
Code 82250, was the assigned code. However, the AMA indicated that it was
reviewing coding in this area generally. Although we believe that the original
code assignment to our ColorMate(R) TLc-BiliTest(R) System was correct, we
cannot assure you that our belief will be sustained. Claims for reimbursement
under CPT Code 84999 may not be as readily processed for reimbursement as claims
made under CPT Code 82250.

YEAR 2000 ISSUE RISKS MAY RESULT IN A MATERIAL ADVERSE EFFECT ON OUR BUSINESS

     Although we do not presently believe that, with upgrades of existing
software and/or conversion to new software, the year 2000 problem will pose
significant operational problems for our internal computer systems or have a
negative affect on our financial position or results of operations, we are
dependent on third parties for the manufacturing and marketing of our
ColorMate(R) TLc-BiliTest(R) System and we cannot assure you that any year 2000
compliance problems of these third parties will not negatively affect our
financial position or results of operations. If we or any third parties upon
which we rely are unable to address the year 2000 issue in a timely manner, it
could have a materially adverse effect on our financial position and results of
operations. In order to assure that this does not occur, we are in the process
of developing a contingency plan and intend to devote all resources required to
attempt to resolve any significant year 2000 issues in a timely manner.

                                       10
<PAGE>
WE EXPECT TO ISSUE ADDITIONAL SHARES IN THE FUTURE WHICH WOULD DILUTE THE
OUTSTANDING SHARES

     In order to finance the commercialization of our ColorMate(R)
TLc-BiliTest(R) System and other applications of our ColorMate(R) System, we
expect to issue and sell additional shares of our common stock or securities
convertible into our common stock, such as the securities which we issued to the
selling stockholders, in the future. As of December 1, 1999, a total of
27,132,622 shares of our common stock were authorized but unissued and
unreserved. These shares may be issued in the future without stockholder
approval. The prices at which we sell these securities and other terms and
provisions will depend on prevailing market conditions and other factors in
effect at that time, all of which are beyond our control. Shares may be issued
at prices which are less than the then-current market price of our common stock
and/or at prices which are less than the prices at which the shares of common
stock being offered by the selling stockholders hereby are sold.

THE TERMS OF THE CONVERTIBLE DEBENTURES AND THE CONVERTIBLE PREFERRED STOCK MAY
ADVERSELY AFFECT THE RIGHTS OF THE COMMON STOCK HOLDERS.

     Unless converted the convertible debentures and the convertible preferred
stock will be entitled to priority of payment upon maturity or redemption, as
the case may be, or in the event we are liquidated and dissolved in preference
to any distribution to the holders of our common stock. In addition, for as long
as the shares of convertible preferred stock are outstanding we are prohibited
from issuing any class or series of preferred stock with a priority of payment
superior or equal to the priority of payment of the convertible preferred stock.

                                 RECENT EVENTS

     In order to provide the ColorMate(R) TLc-BiliTest(R)System to hospitals,
the medical community including clinics, pediatricians and home healthcare
providers and physicians and to expedite evaluation of the product by the
medical community we have taken a series of significant steps in the past
12 months:

          o In November 1998, we opened our medical division, supervised by
            Sheila Kempf, Vice President Medical Division. Ms. Kempf is a former
            Vice President-Marketing of Corometrics, a Marquette Medical Inc.
            company, and a former Director of Marketing for sensors and
            accessories of Nelcor Puritan Bennet, Inc. and has over 13 years
            experience in the medical marketing field. We also hired neonatal
            nurse clinical specialists to provide training to hospital staffs
            using our ColorMate(R) TLc-BiliTest(R) System. The newly-formed
            medical division provides sales support for the ColorMate(R)
            TLc-BiliTest(R) System delivered to consumers in the medical
            community, including hospitals, pediatricians, clinics and home
            healthcare agencies, and performs delivery, training and
            in-servicing for customers initially generated by our presentations
            to the medical community.

          o In November 1998, we entered into a manufacturing agreement with an
            ISO 9001 certified manufacturer, Nova Biomedical of Waltham,
            Massachusetts for the production of our ColorMate(R) TLc-BiliTest(R)
            System and in February 1999 we began making limited shipments of
            this product.

          o In January 1999, we formed a five-person sales unit to be led by
            Dennis A. McClinton, Vice President of Sales. Mr. McClinton has an
            18-year background in sales of fetal and neonatal ICU monitoring
            products at Marquette Medical Systems and will head a staff that
            averages ten years experience in that field. This new unit is
            responsible for the initial sales activity for our ColorMate(R)
            TLc-BiliTest(R) System. The ColorMate(R) TLc-BiliTest(R) System as
            currently marketed by our medical division has a list price of
            $3,000 to $6,000 depending on the model. It may be leased or used
            under the limited time offer for use and evaluation of the system,
            all with either purchase of minimum monthly supplies of the
            TLc-Lensette(TM) calibration standards at $10 per unit, or minimum
            monthly charges of $10 per use or under a managed use program.

          o In January, 1999 we applied for ISO 9001/EN46001 certification and
            the right to affix the CE mark to our ColorMate(R) TLc-BiliTest(R)
            System in order to market this product in the European Union. ISO
            9001/EN46001 certification recognizes that we have established a
            quality system for the design, development, manufacturing, servicing
            and distribution of this product. The CE mark is a symbol of
    quality and compliance with applicable European Union medical
    device directives.

                                       11
<PAGE>
            We have received both the
            ISO 9001/EN46001 certification and the right to affix the CE mark to
            our ColorMate(R) TLc-BiliTest(R) System.

          o In June 1999 we entered into an agreement for the exclusive
            distribution of the ColorMate(R) TLc-BiliTest(R) System in the
            hospital, pediatricians' offices and home healthcare markets
            including clinics related to these markets in the United States with
            Datex-Ohmeda, Inc. and its Ohmeda Medical Division. This agreement
            provided for a four-month transition period before the new
            distributor would begin distribution of this product. Revenues will
            be generated under this agreement from sales of our ColorMate(R)
            TLc-BiliTest(R) System and our TLc-Lensette(TM) calibration
            standards directly to Datex-Ohmeda, Inc., as well as through a
            percentage of the resale price received by the distributor for each
            product.

     In order to finance our activities, we recently completed two private
placements of securities. In April 1999, we completed the private placement of
$5 million in principal amount of 14% senior convertible debentures to six of
the selling stockholders for aggregate proceeds of $5 million. The 14% senior
convertible debentures:

          o accrue interest at the annual rate of 14%, payable at our option in
            cash or in shares of our common stock upon conversion of the senior
            convertible debentures or the maturity date,

          o mature on April 15, 2002 if not sooner converted,

          o are partially convertible into shares of our common stock prior to
            April 14, 2000, at a price of $5.00 per share, subject to adjustment
            for stock splits, combinations and similar recapitalizations
            affecting our common stock, so long as not more than 200,000 shares
            in total are issued upon partial conversion,

          o are fully convertible into shares of our common stock from and after
            April 14, 2000, at a price of $5.00 per share, subject to adjustment
            for stock splits, combinations and similar recapitalizations
            affecting our common stock,

          o may be prepaid by us at any time after October 15, 2000 at 100% of
            the principal amount plus all accrued but unpaid interest and

          o are subject to mandatory conversion into shares of our common stock
            at our option at any time after October 15, 2000 if the average
            closing bid price of our common stock for ten consecutive trading
            days equals or exceeds $10.29.

     In connection with this private placement, we agreed to register the shares
of our common stock issuable upon the conversion of the senior convertible
debentures for resale by the holders under the Securities Act of 1933 and to use
our best efforts to maintain the effectiveness of this registration statement
until the earlier of the date that all of the shares of our common stock
issuable upon the conversion of the senior convertible debentures have been sold
and the date that the number of remaining shares of our common stock issued or
issuable upon the conversion may be freely sold pursuant to SEC Rule 144 in any
period of three consecutive months.

     In June 1999, we completed a private placement of 40,000 shares of
convertible preferred stock and warrants to purchase 220,690 shares of our
common stock to an affiliate of Lehman Brothers, Inc. for aggregate proceeds of
$4 million. The shares of convertible preferred stock issued on that date:

          o are convertible into shares of our common stock at a price of $6.96
            per share, subject to adjustment for stock splits, combinations and
            similar recapitalizations affecting our common stock and to downward
            adjustment if we issue or agree to issue additional shares of our
            common stock (excluding options under our option plan and a limited
            number of other securities excluded under the terms of the agreement
            with the Lehman Brothers affiliate) at a price of less than $6.96
            per share to the price at which we issue or agree to issue the
            lower-priced shares of our common stock or securities convertible or
            exchangeable for shares of our common stock,

          o are redeemable in cash for an amount equal to $115 per share of
            convertible preferred stock on the third anniversary of the date of
            initial issuance if not sooner converted unless we elect in our
            discretion to extend the redemption date to the fifth anniversary of
            the date of initial issuance,

                                       12
<PAGE>
          o are subject to mandatory conversion into shares of our common stock
            at our option at any time after December 15, 1999 if the average
            closing bid price of our common stock for ten consecutive trading
            days equals or exceeds $10.88 per share,

          o are not entitled to any voting rights except as otherwise required
            by applicable law and

          o are not entitled to any dividend rights unless we elect to extend
            the redemption date to the fifth anniversary of the date of initial
            issuance, in which case dividends would accrue at the rate of 8%
            from and after the third anniversary of the date of initial issuance
            which could be paid in shares of our common stock at our option.

     In addition to the shares of convertible preferred stock, on June 15, 1999
we also issued an aggregate of 220,690 warrants to purchase shares of our common
stock to the Lehman Brothers affiliate. An additional 50,000 warrants were
issued to the Lehman Brothers affiliate as compensation for services rendered in
connection with the placement of the convertible preferred stock. The warrants
issued on that date:

          o have a five-year term unless sooner exercised,

          o are exercisable for shares of our common stock at a price of $7.92
            per share, subject to adjustment in the same circumstances as the
            shares of convertible preferred stock described above and

          o are subject to mandatory exercise into shares of our common stock at
            our option at any time after December 15, 1999 if the average
            closing bid price of our common stock measured over twenty
            consecutive trading days equals or exceeds $16.50.

     We also agreed to issue and sell an additional 40,000 shares of convertible
preferred stock and warrants to purchase 270,690 shares of our common stock to
the Lehman Brothers affiliate at a second closing. The second closing is subject
to the satisfaction of several conditions, including the effectiveness of the
registration statement of which this prospectus forms a part. The terms of the
convertible preferred stock to be sold at the second closing would be identical
to the convertible preferred terms described above except that the conversion
price would be equal to the lower of $6.96 per share or 90% of the average
closing bid price of our common stock over the five consecutive trading days
ending on the date prior to the second closing date. The terms of the warrants
to be sold at the second closing would be identical to the warrant terms
described above except that the exercise price would be equal to the lower of
$7.92 per share or 100% of the average closing bid price of our common stock
over the five consecutive trading days ending on the date prior to the second
closing date. We may elect in our discretion not to proceed with the second
closing if the conversion price of the convertible preferred stock to be sold
would be less than $6.96 per share or if the exercise price of the warrants to
be sold would be less than $7.92 per share.

     In connection with this private placement, we agreed to register the shares
of our common stock issuable upon the conversion of the convertible preferred
stock and warrants for resale by the Lehman Brothers affiliate under the
Securities Act of 1933 and to use our best efforts to maintain the effectiveness
of this registration statement until the date that all of the shares of our
common stock issuable upon the conversion of the convertible preferred stock and
warrants have been sold.

                                       13
<PAGE>
                       WHERE YOU CAN GET MORE INFORMATION

     We are a reporting company and file annual, quarterly and current reports,
proxy statements and other information with the SEC. You may read and copy these
reports, proxy statements and other information at the SEC's public reference
rooms in Washington, DC, New York, NY and Chicago, IL. You can request copies of
these documents by writing to the SEC and paying a fee for the copying cost.
Please call the SEC at 1-800-SEC-0330 for more information about the operation
of the public reference rooms. Our SEC filings are also available at the SEC's
web site at "http://www.sec.gov." In addition, you can read and copy our SEC
filings at the office of the National Association of Securities Dealers, Inc. at
1735 K Street, N.W., Washington, DC 20006.

     The SEC allows us to "incorporate by reference" information that we file
with it, which means that we can disclose important information to you by
referring you to those documents. The information incorporated by reference is
an important part of this prospectus, and information that we file later with
the SEC will automatically update and supersede this information. We incorporate
by reference the documents listed below and any future filings we will make with
the SEC under Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act
of 1934:


          o Annual Report on Form 10-K for the year ended December 31, 1998
            filed April 19, 1999, as amended by Form 10-K/A filed April 29,
            1999, as further amended by Form 10-K/A filed November 12, 1999,
            Form 10-K/A-2 filed November 15, 1999, Form 10-K/A-3 filed
            January 21, 2000, and Form 10-K/A-4 filed January 25, 2000,


          o Current Report on Form 8-K filed April 30, 1999,


          o Quarterly Report on Form 10-Q for the three months ended March 31,
            1999 filed May 17, 1999, as amended by Form 10-Q/A filed
            November 12, 1999 and Form 10-Q/A-2 filed January 21, 2000,



          o Current Report on Form 8-K filed June 18, 1999, as amended by
            Form 8-K/A filed November 19, 1999, Form 8-K/A-2 filed
            January 21, 2000, and Form 8-K/2A filed January 28, 2000,


          o Current Report on Form 8-K filed July 1, 1999,


          o Quarterly Report on Form 10-Q for the three months ended June 30,
            1999 filed August 23, 1999, as amended by Form 10-Q/A filed
            January 21, 2000,



          o Quarterly Report on Form 10-Q for the three months ended
            September 30, 1999 filed November 15, 1999, as amended by
            Form 10-Q/A filed January 21, 2000,


          o The description of the common stock contained in Chromatics Color
            Sciences International, Inc. Registration Statement on Form 8-A
            filed February 1, 1993,

          o The description of the purchase rights for Class B Series 1
            preferred stock contained in the Chromatics Color Sciences
            International, Inc. Registration Statement on Form 8-A filed
            January 5, 1999,

          o Registration Statement on Form 8-A/A amending the description of the
            common stock filed November 12, 1999,

          o Registration Statement on Form 8-A/A amending the description of the
            purchase rights for Class B Series 1 preferred stock filed
            November 12, 1999,


          o Current Report on form 8-K/2A filed January 28, 2000 and Form
            8-K/A filed November 19, 1999, amending our Form 8-K filed
            November 3, 1998 and


          o Proxy Statement for 1999 Annual Meeting of Stockholders to be held
            on December 20, 1999.

     You may request a copy of these filings at no cost, by writing or
telephoning us at the following address:
                        Ms. Leslie Foglesong
                   Secretary
                   Chromatics Color Sciences International, Inc.
                   5 East 80th Street


<PAGE>
                   New York, NY 10021
                   (212) 717-6544

                                       14
<PAGE>
                                USE OF PROCEEDS

     We will not receive any proceeds resulting from the sale of the shares of
common stock by the selling stockholders, but we will receive the proceeds from
the exercise of the warrants.

                           FORWARD-LOOKING STATEMENTS

     This prospectus contains forward-looking statements within the meaning of
Section 27A of the Securities Act of 1933 and Section 21E of the Securities
Exchange Act of 1934, and information about our financial condition, results of
operations and business that are based on our current and future expectations.
The words "believe," "anticipate," "expect," "intend," and words of similar
import are intended to identify these statements as forward-looking statements.
These forward-looking statements include the following:

          o our belief that our existing capital resources will be adequate to
            fund our needs for at least the next 12 months,

          o our belief that our ColorMate(R) System and/or our
            ColorMate(R) TLc-BiliTest(R) System can be marketed in the medical,
            dental, biological, cosmetic, industrial, soil contamination, hair
            color, beauty-aid or fashion industries,

          o our belief that the size of the infant jaundice monitoring market in
            the United States is approximately 15,000,000 tests annually and
            approximately the same size in Europe and in Asia, South America and
            Australia combined and that non-invasive monitoring could
            potentially increase the amount of annual tests performed,

          o our belief that our ColorMate(R) System can be successfully
            commercialized for other applications,

          o our belief that we will be successful in attracting and retaining
            additional qualified personnel,

          o our belief that the medical community will accept our
            ColorMate(R) TLc-BiliTest(R) System,

          o our belief that we can successfully mass manufacture our
            ColorMate(R) TLc-BiliTest(R) System, our TLc Lensette(TM)
            calibration standards and protective liners and our
            ColorMate(R) System,

          o our belief that we can successfully generate revenues from the
            commercialization of our intellectual property,

          o our belief that we can successfully contract with a third party to
            distribute our ColorMate(R) TLc-BiliTest(R) System for the
    international markets or the parents market or expand our sales
    into these markets through our own medical division, although
    marketing our ColorMate(R) TLc-BiliTest(R) System for the parents'
    use would require more product testing as well as FDA marketing
    clearances and international and other marketing clearances or
            approvals, and there is no assurance that such clearances or
    approvals would be granted, and

          o our belief that our distribution partner, Datex-Ohmeda, Inc., will
            be successful in penetrating its targeted markets within the
            projected time periods.

     Forward-looking statements necessarily involve risks and uncertainties, and
our actual results could differ materially from those anticipated in the
forward-looking statements, including those set forth under "Risk Factors" and
elsewhere in this prospectus. We caution you that no forward-looking statement
is a guarantee of future performance. You should not place undue reliance on
these forward-looking statements, which speak only of the date of this
prospectus. We do not undertake any obligation to publicly release any revisions
to these forward-looking statements to reflect events or circumstances after the
date of this prospectus or to reflect the occurrence of unanticipated events
which may cause our actual results to differ from those expressed or implied by
the forward-looking statements contained in this prospectus. The factors set
forth under "Risk Factors" and other cautionary statements made in this
prospectus should be read and understood as being applicable to all related
forward-looking statements wherever they appear in this prospectus.

                                       15
<PAGE>
                              SELLING STOCKHOLDERS

     In private placements concluded in April 1999 and June 1999 we sold to the
selling stockholders convertible debt securities, convertible preferred stock
and warrants to purchase our common stock, and agreed to register the shares of
common stock issuable upon the conversion of these convertible debt securities
and convertible preferred stock and the exercise of warrants for resale of these
securities by the selling stockholders. We also agreed to use our commercially
reasonable best efforts to maintain the effectiveness of the registration
statement until all of the shares are sold under the registration statement or
until the date that they may be sold by the selling stockholders without
registration. Our registration of the shares of common stock does not
necessarily mean that the selling stockholders will sell all or any of the
shares.

     The following table sets forth pertinent information regarding the
beneficial ownership of the common stock, as of September 30, 1999, of each of
the selling stockholders. The information provided in the table below with
respect to each selling stockholder has been obtained from the selling
stockholder. Except as otherwise disclosed below, none of the selling
stockholders has, or within the past three years has had, any position, office
or other material relationship with us. Because the selling stockholders may
sell all or some portion of the shares of common stock beneficially owned by
them, we cannot estimate the number of shares of common stock that will be
beneficially owned by the selling stockholders after this offering. In addition,
the selling stockholders may have sold, transferred or otherwise disposed of, or
may sell, transfer or otherwise dispose of, at any time or from time to time
since the date on which they provided the information regarding the shares of
common stock beneficially owned by them, all or a portion of the shares of
common stock beneficially owned by them in transactions exempt from the
registration requirements of the Securities Act of 1933. The following table
assumes that all of the shares of common stock being registered will be sold by
the selling stockholders.

     Beneficial ownership is determined in accordance with
Rule 13d-3(d) promulgated by the SEC under the Securities Exchange Act of 1934,
as amended. Shares of common stock issuable pursuant to options, warrants and
convertible securities, to the extent these securities are currently exercisable
or convertible within 60 days of September 30, 1999, are treated as outstanding
for computing the percentage of the person holding these securities but are not
treated as outstanding for computing the percentage of any other person. Unless
otherwise noted, each person identified possesses sole voting and investment
power with respect to the shares. Shares not outstanding but deemed beneficially
owned by virtue of the right of a person to acquire them within 60 days are
treated as outstanding only for purposes of determining the number of and
percent owned by that person.

                                       16
<PAGE>

<TABLE>
<CAPTION>
                                          NUMBER OF SHARES            NUMBER OF SHARES       NUMBER OF SHARES      PERCENTAGE
            NAME OF SELLING               BENEFICIALLY OWNED          REGISTERED FOR SALE    BENEFICIALLY OWNED    OWNERSHIP
            STOCKHOLDER(12)               AS OF SEPTEMBER 30, 1999      HEREUNDER            AFTER OFFERING        AFTER OFFERING
- ---------------------------------------   ------------------------    -------------------    ------------------    --------------
<S>                                       <C>                         <C>                    <C>                   <C>
LB I Group Inc.  ......................            845,403(1)                845,403(2)               0                   0%
  3 World Financial Center
  New York, New York 10285
B.J.S. Trust ..........................             40,000(3)                200,000(4)               0                   0%
  c/o P.O. Box 400
  Sterling, IL 61081
G.W.S. Trust ..........................             40,000(5)                200,000(4)               0                   0%
  c/o P.O. Box 400
  Sterling, IL 61081
S.M.S. Trust ..........................             40,000(6)                200,000(4)               0                   0%
  c/o P.O. Box 400
  Sterling, IL 61081
L.B.P. Trust ..........................             40,000(7)                200,000(4)               0                   0%
  c/o P.O. Box 400
  Sterling, IL 61081
G. W. Schreiner Trust .................             36,000(8)                180,000(9)               0                   0%
  c/o P.O. Box 400
  Sterling, IL 61081
G.A.P. Trust ..........................              4,000(10)                20,000(11)              0                   0%
  c/o P.O. Box 400
  Sterling, IL 61081
</TABLE>

- ------------------
 (1) Represents 574,713 shares of common stock which may be acquired within
     60 days of September 30, 1999 upon the conversion of the convertible
     preferred stock held by the selling stockholder and 270,690 shares of
     common stock which may be acquired within 60 days of September 30, 1999
     upon the exercise of the warrants issued to the selling stockholder.
     Mr. Frederick Frank, Vice Chairman of Lehman Brothers, Inc., has been an
     advisor to us since December 1, 1997, providing financial, strategic and
     business advisory services. The consulting agreement with Mr. Frank expired
     December 1, 1998 but was renewed by mutual agreement of Mr. Frank and us.
     Lehman Brothers Holdings Inc. is the sole stockholder of LB I Group Inc.
     and, as such, is deemed to be the beneficial owner of these shares in
     accordance with Rule 13d-3(d) promulgated by the SEC under the Securities
     Exchange Act of 1934, as amended. Lehman Brothers Holdings Inc. and LB I
     Group Inc. are affiliates of Lehman Brothers, Inc., a registered
     broker-dealer. LB I Group Inc. purchased the shares of convertible
     preferred stock and warrants and will purchase the shares of our common
     stock issuable upon conversion or exercise of these securities in the
     ordinary course of its business and at the time of this purchase,
     conversion, or exercise, did not and will not have any agreements or
     understandings, directly or indirectly, with any person to distribute these
     securities.

(2) Represents 574,713 shares of common stock which may be acquired within
    60 days of September 30, 1999 upon the conversion of the convertible
    preferred stock held by the selling stockholder and 270,690 shares of common
    stock which may be acquired within 60 days of September 30, 1999 upon the
    exercise of the warrants issued to the selling stockholder.


(3) Represents shares of common stock which may be acquired within 60 days of
    September 30, 1999 upon the conversion of the convertible debenture held by
    the selling stockholder. Does not include up to an additional 160,000 shares
    of common stock which may be acquired by the selling stockholder upon the
    conversion of the entire outstanding principal amount of the convertible
    debenture held by the selling stockholder at any time after April 15, 2000.
    Does not include up to an additional 84,000 shares of common stock which may
    be acquired by the selling stockholder upon the conversion of all interest
    accrued through April 15, 2002 with respect to the convertible debenture
    held by the selling stockholder. Bradley J. Schreiner, as trustee of the
    B.J.S. Trust, and Gary W. Schreiner, pursuant to an Assignment Agreement,
    dated as of October 21, 1999, are deemed to be the beneficial owners of
    these shares


                                              (Footnotes continued on next page)

                                       17
<PAGE>
(Footnotes continued from previous page)

    in accordance with Rule 13d-3(d) promulgated by the SEC under the Securities
    Exchange Act of 1934, as amended.

(4) Represents 200,000 shares of common stock which can be acquired by the
    selling stockholder upon the conversion of the entire principal amount of
    convertible debenture held by the selling stockholder.


(5) Represents shares of common stock which may be acquired within 60 days of
    September 30, 1999 upon the conversion of the convertible debenture held by
    the selling stockholder. Does not include up to an additional 160,000 shares
    of common stock which may be acquired by the selling stockholder upon the
    conversion of the entire outstanding principal amount of the convertible
    debenture held by the selling stockholder at any time after April 15, 2000.
    Does not include up to an additional 84,000 shares of common stock which may
    be acquired by the selling stockholder upon the conversion of all interest
    accrued through April 15, 2002 with respect to the convertible debenture
    held by the selling stockholder. Gregory W. Schreiner, as trustee of the
    G.W.S. Trust, and Gary W. Schreiner, pursuant to an Assignment Agreement,
    dated as of October 21, 1999, are deemed to be the beneficial owners of
    these shares in accordance with Rule 13d-3(d) promulgated by the SEC under
    the Securities Exchange Act of 1934, as amended.


(6) Represents shares of common stock which may be acquired within 60 days of
    September 30, 1999 upon the conversion of the convertible debenture held by
    the selling stockholder. Does not include up to an additional 160,000 shares
    of common stock which may be acquired by the selling stockholder upon the
    conversion of the entire outstanding principal amount of the convertible
    debenture held by the selling stockholder at any time after April 15, 2000.
    Does not include up to an additional 84,000 shares of common stock which may
    be acquired by the selling stockholder upon the conversion of all interest
    accrued through April 15, 2002 with respect to the convertible debenture
    held by the selling stockholder. Steven M. Schreiner, as trustee of the
    S.M.S. Trust, and Gary W. Schreiner, pursuant to an Assignment Agreement,
    dated as of October 21, 1999, are deemed to be the beneficial owners of
    these shares in accordance with Rule 13d-3(d) promulgated by the SEC under
    the Securities Exchange Act of 1934, as amended.



(7) Represents shares of common stock which may be acquired within 60 days of
    September 30, 1999 upon the conversion of the convertible debenture held by
    the selling stockholder. Does not include up to an additional 160,000 shares
    of common stock which may be acquired by the selling stockholder upon the
    conversion of the entire outstanding principal amount of the convertible
    debenture held by the selling stockholder at any time after April 15, 2000.
    Does not include up to an additional 84,000 shares of common stock which may
    be acquired by the selling stockholder upon the conversion of all interest
    accrued through April 15, 2002 with respect to the convertible debenture
    held by the selling stockholder. James N. Bergman, as trustee of the L.B.P.
    Trust, and Gary W. Schreiner, pursuant to an Assignment Agreement,
    dated as of October 21, 1999, are deemed to be the beneficial owners of
    these shares in accordance with Rule 13d-3(d) promulgated by the SEC under
    the Securities Exchange Act of 1934, as amended.


(8) Represents shares of common stock which may be acquired within 60 days of
    September 30, 1999 upon the conversion of the convertible debenture held by
    the selling stockholder. Does not include up to an additional 144,000 shares
    of common stock which may be acquired by the selling stockholder upon the
    conversion of the entire outstanding principal amount of the convertible
    debenture held by the selling stockholder at any time after April 15, 2000.
    Does not include up to an additional 75,600 shares of common stock which may
    be acquired by the selling stockholder upon the conversion of all interest
    accrued through April 15, 2002 with respect to the convertible debenture
    held by the selling stockholder. Gary W. Schreiner, as trustee of the G. W.
    Schreiner Trust, and pursuant to an Assignment Agreement, dated as of
    October 21, 1999, is deemed to be the beneficial owner of these shares in
    accordance with Rule 13d-3(d) promulgated by the SEC under the Securities
    Exchange Act of 1934, as amended.


(9) Represents 180,000 shares of common stock which can be acquired by the
    selling stockholder upon the conversion of the entire principal amount of
    convertible debenture held by the selling stockholder.

                                              (Footnotes continued on next page)

                                       18
<PAGE>
(Footnotes continued from previous page)


(10) Represents shares of common stock which may be acquired within 60 days of
     September 30, 1999 upon the conversion of the convertible debenture held by
     the selling stockholder. Does not include up to an additional 16,000 shares
     of common stock which may be acquired by the selling stockholder upon the
     conversion of the entire outstanding principal amount of the convertible
     debenture held by the selling stockholder at any time after April 15, 2000.
     Does not include up to an additional 8,400 shares of common stock which may
     be acquired by the selling stockholder upon the conversion of all interest
     accrued through April 15, 2002 with respect to the convertible debenture
     held by the selling stockholder. Gary W. Schreiner, as trustee of the
     G.A.P. Trust, and Gary W. Schreiner, pursuant to an Assignment Agreement,
     dated as of October 21, 1999, are deemed to be the beneficial owners of
     these shares in accordance with Rule 13d-3(d) promulgated by the SEC under
     the Securities Exchange Act of 1934, as amended.


(11) Represents 20,000 shares of common stock which can be acquired by the
     selling stockholder upon the conversion of the entire principal amount of
     convertible debenture held by the selling stockholder.

(12) The original purchaser of the convertible debentures was Gary W. Schreiner.
     Pursuant to an Assignment Agreement, dated as of October 21, 1999, Mr.
     Schreiner assigned portions of his interest in the convertible debentures
     to:

     o B.J.S. Trust, for the benefit of his son, Bradley J. Schreiner,

     o G.W.S. Trust, for the benefit of his son, G.W. Schreiner,

     o S.M.S. Trust, for the benefit of his son, Steven M. Schreiner,

     o G.W. Schreiner Trust, for his personal benefit,

     o L.B.P. Trust, for the benefit of an unrelated third party, and

     o G.A.P. Trust, for his personal benefit.

     With the exception of the relationship which is disclosed in the Prospectus
     between Chromatics and Frederick Frank of Lehman Brothers Holdings, Inc.,
     which is an affiliate of LB I Group Inc., none of the selling stockholders
     has any prior relationship with Chromatics.

                              PLAN OF DISTRIBUTION

     The selling stockholders or their transferees may, from time to time, sell
all or a portion of the shares of common stock being registered pursuant to this
prospectus in privately negotiated transactions or otherwise, at fixed prices
that may be changed, at market prices prevailing at the time of sale, at prices
related to these market prices or at negotiated prices. The shares may be sold
by the selling stockholders by one or more of the following methods, without
limitation:

          o block trades in which the broker or dealer so engaged will attempt
            to sell the shares as agent but may position and resell a portion of
            the block as principal to facilitate the transaction,

          o purchases by a broker or dealer as principal and resale by that
            broker or dealer for its account pursuant to this prospectus,

          o an exchange distribution in accordance with the rules of the
            applicable exchange,

          o ordinary brokerage transactions and transactions in which the broker
            solicits purchasers,

          o privately negotiated transactions,

          o short sales,

          o a combination of any of these methods of sale and

          o any other method permitted pursuant to applicable law.

                                       19
<PAGE>
     The selling stockholders and any broker-dealers or agents that participate
with the selling stockholders in sales of the shares may be deemed to be
"underwriters" within the meaning of the Securities Act of 1933 in connection
with these sales. If so, any commissions received by these broker-dealers or
agents and any profit on the resale of the shares purchased by them may be
deemed to be underwriting commissions or discounts under the Securities Act of
1933.


     We retained Lehman Brothers, Inc. to serve as placement agent for the
securities that were ultimately placed with LB I Group Inc. in the June, 1999
financing. For its services, Lehman Brothers, Inc. was entitled to cash
compensation in addition to warrants to purchase our common stock at an exercise
price of $7.92 per share. Lehman Brothers, Inc. requested that these warrants be
issued in the name of LB I Group rather than its own name. LB I Group Inc. is
deemed to be an underwriter with respect to any shares sold pursuant to this
registration statement.


     From time to time, the selling stockholders may engage in short sales,
short sales against the box (in which the seller owns shares of our common stock
at the time of the sale but borrows other shares of our common stock to sell in
the short sale), puts and calls and other transactions in our securities or
derivatives of these securities, and may sell and deliver the shares in
connection therewith or in settlement of securities loans. From time to time,
the selling stockholders may pledge their shares pursuant to the margin
provisions of their customer agreements with their brokers. Upon a default by
the selling stockholders, the broker may offer and sell the pledged shares from
time to time.

     In effecting sales, brokers and dealers engaged by the selling stockholders
may arrange for other brokers or dealers to participate in these sales. Brokers
or dealers may receive commissions or discounts from the selling stockholders
(or, if any broker-dealer acts as agent for the purchaser of the shares, from
that purchaser) in amounts to be negotiated which are not expected to exceed
those customary in the types of transactions involved. Broker-dealers may agree
with the selling stockholders to sell a specified number of shares at a
stipulated price per share, and, to the extent the broker-dealer is unable to do
so acting as agent for a selling stockholder, to purchase as principal any
unsold shares at the price required to fulfill the broker-dealer commitment to
the selling stockholders.

     Broker-dealers who acquire shares as principal may thereafter resell the
shares from time to time in transactions (which may involve block transactions
and sales to and through other broker-dealers, including transactions of the
nature described above) in the over-the-counter market or otherwise at prices
and on terms then prevailing at the time of sale, at prices then related to the
then-current market price or in negotiated transactions and, in connection with
these resales, may pay to or receive from the purchasers of the shares
commissions as described above. The selling stockholders may also sell the
shares in accordance with Rule 144 under the Securities Act of 1933, rather than
pursuant to this prospectus.

     We have agreed to indemnify the selling stockholders against losses,
claims, damages and liabilities arising under the Securities Act of 1933.

     We have informed the selling stockholders that the anti-manipulation
provisions of Regulation M under the Securities Exchange Act of 1934 may apply
to the sales of their shares offered hereby. We have also advised the selling
stockholders of the requirement for delivery of this prospectus in connection
with any sale of the shares offered hereby.

     The selling stockholders may from time to time purchase shares of common
stock in the open market. They have been notified that they should not commence
any distribution of shares unless they have terminated their purchasing and
bidding for common stock in the open market as provided in applicable securities
regulations.

     There is no assurance that the selling stockholders or their transferees
will sell any or all of the shares offered by them in this prospectus.

                                       20
<PAGE>
                                 LEGAL MATTERS

     The validity of the shares of common stock offered hereby will be passed
upon for us by Patterson, Belknap, Webb & Tyler LLP, 1133 Avenue of the
Americas, New York, New York.

                                    EXPERTS

     Our financial statements as of December 31, 1998 and for the year ended
December 31, 1998 incorporated by reference in this prospectus and registration
statement have been audited by BDO Seidman  LLP, independent auditors, as set
forth in their report dated March 15, 1999, except for note 6, which is dated
April 15, 1999 and are included in reliance upon the authority of BDO
Seidman LLP as experts in accounting and auditing. Our financial statements as
of December 31, 1997 and for the years ending December 31, 1997 and 1996
incorporated by reference in this prospectus and registration statement have
been audited by Wiss & Company, independent auditors, as set forth in their
report dated February 17, 1998 and are included in reliance upon the authority
of Wiss & Company as experts in accounting and auditing.

                                       21
<PAGE>
- ------------------------------------------------------
                          ------------------------------------------------------
- ------------------------------------------------------
                          ------------------------------------------------------

     WE HAVE NOT AUTHORIZED ANY DEALER, SALESMAN OR OTHER PERSON TO MAKE ANY
REPRESENTATION NOT CONTAINED IN THIS PROSPECTUS. DO NOT RELY ON ANY INFORMATION
OR REPRESENTATION NOT CONTAINED IN HEREIN. THIS PROSPECTUS IS NOT AN OFFER TO
SELL ANY OF THE SECURITIES OFFERED HEREBY IN THOSE JURISDICTIONS WHERE SUCH AN
OFFER WOULD BE UNLAWFUL.
                            ------------------------

                                    CONTENTS

<TABLE>
<CAPTION>
                                                  PAGE
                                                  ----
<S>                                               <C>
Summary of the Offering........................      2
Risk Factors...................................      4
Recent Events..................................     11
Where You Can Get More Information.............     14
Use of Proceeds................................     15
Forward-Looking Statements.....................     15
Selling Stockholders...........................     16
Plan of Distribution...........................     19
Legal Matters..................................     21
Experts........................................     21
</TABLE>

                              1,845,403 SHARES OF
                                  COMMON STOCK

                                CHROMATICS COLOR
                                    SCIENCES
                              INTERNATIONAL, INC.
                            ------------------------
                                   PROSPECTUS
                            ------------------------

                                JANUARY 28, 2000


                          ------------------------------------------------------
                          ------------------------------------------------------
                          ------------------------------------------------------
                          ------------------------------------------------------
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

     The following table sets forth the various estimated amount of fees and
expenses payable in connection with this offering other than sales commissions.
All of these expenses will be borne by the registrant.

<TABLE>
<CAPTION>
                         ITEM                            AMOUNT OF EXPENSES
- ------------------------------------------------------   ------------------
<S>                                                      <C>
SEC Registration Fee..................................      $   7,603.06
Printing Expenses.....................................            60,000*
Accounting Fees and Expenses..........................            10,000*
Legal Fees and Expenses...............................            60,000*
Miscellaneous Expenses................................             1,000*
                                                            ------------
  Total...............................................      $ 138,603.06*
</TABLE>

- ------------------
* Estimated

ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

     Section 722 of the Business Corporation Law of the State of New York and
Article X of Chromatics' Certificate of Incorporation contain provisions for the
indemnification of officers and directors of Chromatics. The Certificate of
Incorporation requires Chromatics to indemnify officers and directors to the
full extent permitted by New York Law. Each person will be indemnified in any
proceeding if he or she acted in good faith and in a manner which he or she
reasonably believed to be in, or not opposed to, the best interests of
Chromatics. Indemnification would cover judgments, fines, amounts paid in
settlement and reasonable expenses, including attorney's fees.

     Chromatics has directors' and officers' liability insurance. This insurance
may cover liabilities asserted against any present or past director or officer
incurred in the capacity of director or officer arising out of his or her
status, whether or not Chromatics would have the power to indemnify this person.

ITEM 16. EXHIBITS.

<TABLE>
<CAPTION>
 NUMBER     DESCRIPTION OF DOCUMENT
- ---------   ---------------------------------------------------------------------------------------------
<S>   <C>   <C>
    3.1      --   Restated Articles of Incorporation of Chromatics (incorporated by reference to
                  Exhibit 3.1 to Chromatics' Quarterly Report on Form 10-Q, filed on August 23, 1999).
    3.2      --   By-Laws of Chromatics (incorporated by reference to Exhibit 3.2 to Chromatics'
                  November 5, 1992 Registration Statement).
    4.1      --   Restated Articles of Incorporation of Chromatics (incorporated by reference to
                  Exhibit 3.1 to Chromatics' Quarterly Report on Form 10-Q, filed on August 23, 1999).
    4.2      --   Subscription Agreement, dated April 15, 1999 between Chromatics and Gary W. Schreiner
                  (incorporated by reference to Exhibit 4.1 to Chromatics' Current Report on Form 8-K,
                  filed on April 30, 1999).
    4.3      --   14% Senior Convertible Debenture, due April 15, 2002, in the original principal amount
                  of $5,000,000 (incorporated by reference to Exhibit 4.2 to Chromatics' Current Report
                  on Form 8-K, filed on April 30, 1999).
    4.4      --   Preferred Stock Purchase Agreement, dated as of June 11, 1999, by and between
                  Chromatics and LB I Group Inc. (incorporated by reference to Exhibit 4.1 to Chromatics'
                  Current Report on Form 8-K, filed on July 1, 1999).
    4.5      --   Warrant Agreement, dated as of June 11, 1999, by and between Chromatics and LB I Group
                  Inc. (incorporated by reference to Exhibit 4.2 to Chromatics' Current Report on
                  Form 8-K, filed on July 1, 1999).
</TABLE>

                                      II-1
<PAGE>
ITEM 16. EXHIBITS.


<TABLE>
<CAPTION>
 NUMBER     DESCRIPTION OF DOCUMENT
- ---------   ---------------------------------------------------------------------------------------------
<S>         <C>   <C>
    5.1+     --   Opinion Regarding Legality.
   23.1+     --   Consent of BDO Seidman, LLP.
   23.2+     --   Consent of Wiss & Company, LLP.
   23.3+     --   Consent of Patterson, Belknap, Webb & Tyler LLP (included in Exhibit 5.1).
   24.1+     --   Power of Attorney.
</TABLE>


- ------------------
+ Filed previously.

ITEM 17. UNDERTAKINGS.

(a) The undersigned registrant hereby undertakes:

          (1) to file, during any period in which offers or sales are being
              made, a post-effective amendment to this registration statement:

             (i)  to include any prospectus required by Section 10 (a) (3) of
                  the Securities Act of 1933;

             (ii)  to reflect in the prospectus any facts or events arising
                   after the effective date of the registration statement (or
                   the most recent post-effective amendment thereof) which,
                   individually or in the aggregate, represents a fundamental
                   change in the information set forth in the registration
                   statement;

             (iii) to include any material information with respect to the plan
                   of distribution not previously disclosed in this registration
                   statement or any material change to such information in this
                   registration statement;

provided, however, that paragraphs (i) and (ii) do not apply to this
registration statement if the information required to be included in a
post-effective amendment by those paragraphs is contained in periodic reports
filed by the registrant pursuant to Section 13 or Section 15 (d) of the
Securities Exchange Act of 1934 and incorporated by reference in this
registration statement;

          (2) that, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof;

          (3) to remove from registration by means of a post-effective amendment
     any of the securities being registered which remain unsold at the
     termination of the offering.

(b) the undersigned registrant hereby undertakes that, for the purpose of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13 (a) or Section 15 (d) of the
Securities Exchange Act of 1934 that is incorporated by reference in this
registration statement shall be deemed to be a new registration statement
relating to the securities offered herein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

(c) insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the provisions described in the first paragraph of Item
15 above, or otherwise, the registrant has been advised that in the opinion of
the SEC such indemnification is against public policy as expressed in said
Securities Act of 1933 and is, therefore, unenforceable. In the event that a
claim for indemnification against such liabilities (other than the payment by
the registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any action,
suit, or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the registrant will, unless
in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act of 1933 and will be governed by the final adjudication of such
issue.

                                      II-2
<PAGE>
                                   SIGNATURES



     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Amendment to this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in New York, State of New York, on January 28, 2000.



                                          CHROMATICS COLOR SCIENCES
                                          INTERNATIONAL, INC.



Date: January 28, 2000                    By: ______/s/ DARBY S. MACFARLANE_____
                                                    Darby S. Macfarlane
                                                  Chairperson of the Board
                                                and Chief Executive Officer


     IN ACCORDANCE WITH THE SECURITIES ACT OF 1933, THIS REPORT HAS BEEN SIGNED
BELOW BY THE FOLLOWING PERSONS ON BEHALF OF THE REGISTRANT AND IN THE CAPACITIES
AND ON THE DATES INDICATED.


<TABLE>
<CAPTION>
                SIGNATURE                                     CAPACITY                            DATE
- -----------------------------------------  ----------------------------------------------   -----------------

<S>                                        <C>                                              <C>
         /s/ DARBY S. MACFARLANE           Chairperson of the Board and Chief Executive      January 28, 2000
           Darby S. Macfarlane             Officer (Principal Executive Officer)

          /s/ FRANCIS MARCHESE             Chief Financial Officer                           January 28, 2000
            Francis Marchese               (Principal Financial and Accounting Officer)

                    *                      Director                                          January 28, 2000
            Leslie Foglesong

                    *                      Director, Vice-President--Research and            January 28, 2000
        David Kenneth Macfarlane           Development

                    *                      Director                                          January 28, 2000
              Edmund Vimond

                    *                      Director                                          January 28, 2000
             Edward Mahoney

       By: /s/ DARBY S. MACFARLANE
           Darby S. Macfarlane
            Attorney-In-Fact
</TABLE>


                                      II-3
<PAGE>
                                 EXHIBIT INDEX


<TABLE>
<CAPTION>
  NUMBER     DESCRIPTION OF DOCUMENT
- ----------   --------------------------------------------------------------------------------------------
<S>          <C>   <C>
   3.1        --   Restated Articles of Incorporation of Chromatics (incorporated by reference to
                   Exhibit 3.1 to Chromatics' Quarterly Report on Form 10-Q, filed on August 23, 1999).
   3.2        --   By-Laws of Chromatics (incorporated by reference to Exhibit 3.2 to Chromatics'
                   November 5, 1992 Registration Statement).
   4.1        --   Restated Articles of Incorporation of Chromatics (incorporated by reference to
                   Exhibit 3.1 to Chromatics' Quarterly Report on Form 10-Q, filed on August 23, 1999).
   4.2        --   Subscription Agreement, dated April 15, 1999 between Chromatics and Gary W. Schreiner
                   (incorporated by reference to Exhibit 4.1 to Chromatics' Current Report on Form 8-K,
                   filed on April 30, 1999).
   4.3        --   14% Senior Convertible Debenture, due April 15, 2002, in the original principal amount
                   of $5,000,000 (incorporated by reference to Exhibit 4.2 to Chromatics' Current Report
                   on Form 8-K, filed on April 30, 1999).
   4.4        --   Preferred Stock Purchase Agreement, dated as of June 11, 1999, by and between
                   Chromatics and LB I Group Inc. (incorporated by reference to Exhibit 4.1 to
                   Chromatics' Current Report on Form 8-K, filed on July 1, 1999).
   4.5        --   Warrant Agreement, dated as of June 11, 1999, by and between Chromatics and LB I Group
                   Inc. (incorporated by reference to Exhibit 4.2 to Chromatics' Current Report on
                   Form 8-K, filed on July 1, 1999).
   5.1+       --   Opinion Regarding Legality.
  23.1+       --   Consent of BDO Seidman, LLP.
  23.2+       --   Consent of Wiss & Company, LLP.
  23.3+       --   Consent of Patterson, Belknap, Webb & Tyler LLP (included in Exhibit 5.1).
  24.1+       --   Power of Attorney.
</TABLE>


- ------------------
+ Filed previously.



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