VENTANA MEDICAL SYSTEMS INC
DEF 14A, 1998-03-31
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE
                        SECURITIES EXCHANGE ACT OF 1934
                                (AMENDMENT NO.   )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to 240.14a-11(c) or 240.14a-12

                         VENTANA MEDICAL SYSTEMS, INC.
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
                   (Name of Person(s) Filing Proxy Statement)

Payment of Filing Fee (Check the appropriate box):

[X]  No fee.

[ ]  $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), or 14a-6(j)(2).

[ ]  $500 per each  party  to the  controversy  pursuant  to  Exchange  Act Rule
     14a-6(i)(3).  

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     (1)  Title of each class of securities to which transaction applies:

     (2)  Aggregate number of securities to which transaction applies:

     (3)  Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange Act Rule 0-11:

     (4)  Proposed maximum aggregate value of transaction:

     Set forth the amount on which the filing fee is calculated and state how it
     was determined.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the filing for which the  offsetting  fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     (1)  Amount Previously Paid:

     (2)  Form, Schedule or Registration Statement No.:

     (3)  Filing Party:

     (4)  Date Filed:


<PAGE>


                          VENTANA MEDICAL SYSTEMS, INC.


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                          To be held on April 30, 1998

TO THE STOCKHOLDERS:

     NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders  of VENTANA
MEDICAL SYSTEMS,  INC., a Delaware corporation (the "Company"),  will be held on
Thursday,  April 30, 1998, at 10:00 a.m., local time, at the Arizona Inn, Tucson
Room, 2200 East Elm Street, Tucson, Arizona 85719 for the following purposes (as
more fully described in the Proxy Statement accompanying this Notice):

     1.   To elect two Class II  directors  of the Company to serve for terms of
          three  years   expiring  upon  the  date  of  the  Annual  Meeting  of
          Stockholders  held in the year  2001 or  until  their  successors  are
          elected.

     2.   To approve an  amendment  to the  Company's  1996 Stock Option Plan to
          increase  the number of shares of Common  Stock  reserved for issuance
          thereunder by 750,000 shares to a new total of 1,750,000 shares.

     3.   To ratify  the  appointment  of Ernst & Young  LLP as the  independent
          auditors of the Company for the fiscal year ending December 31, 1998.

     4.   To  transact  such other  business  as may  properly  come  before the
          meeting or any adjournment thereof.

     The  foregoing  items of  business  are more fully  described  in the Proxy
Statement accompanying this Notice.

     Only  stockholders of record at the close of business on March 13, 1998 are
entitled to notice of and to vote at the Annual Meeting.

     All stockholders are cordially invited to attend the meeting.  However,  to
ensure your representation at the meeting, you are urged to mark, sign, date and
return  the  enclosed  proxy as  promptly  as  possible  in the  postage-prepaid
envelope enclosed for that purpose.  If you attend the meeting,  you may vote in
person even if you return a proxy.

                                             FOR THE BOARD OF DIRECTORS

                                              /s/ Jack W. Schuler
                                             ---------------------------------
                                             Jack W. Schuler
                                             Chairman of the Board of Directors

Tucson, Arizona
March 31, 1998



- --------------------------------------------------------------------------------
                                   IMPORTANT
                                   =========

     WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING, PLEASE COMPLETE AND PROMPTLY
     RETURN  THE  ENCLOSED  PROXY IN THE  ENVELOPE  PROVIDED.  IF YOU ATTEND THE
     MEETING, YOU MAY VOTE IN PERSON, EVEN IF YOU RETURN A PROXY.
- --------------------------------------------------------------------------------


<PAGE>

                          VENTANA MEDICAL SYSTEMS, INC.


                               PROXY STATEMENT FOR
                       1998 ANNUAL MEETING OF STOCKHOLDERS

                                 April 30, 1998


              INFORMATION CONCERNING VOTING AND PROXY SOLICITATION

General

     The  enclosed  proxy is  solicited  on behalf of the Board of  Directors of
Ventana Medical Systems, Inc. ("Ventana" or the "Company") for use at the Annual
Meeting of Stockholders to be held on April 30, 1998 at 10:00 a.m.,  local time,
or at any  adjournment  thereof.  The Annual Meeting will be held at the Arizona
Inn, Tucson Room,  2200 East Elm Street,  Tucson,  Arizona 85719.  The telephone
number at the meeting location is (520) 325-1541.

     These proxy  solicitation  materials and the Annual Report to  stockholders
for the fiscal year ended December 31, 1997 (the "Last Fiscal Year"),  including
financial  statements,  were first  mailed on or about  March 31,  1998,  to all
stockholders entitled to vote at the Annual Meeting.

Record Date and Voting Securities

     Stockholders  of  record at the close of  business  on March 13,  1998 (the
"Record Date") are entitled to notice of and to vote at the Annual  Meeting.  At
the Record Date,  13,387,410  shares of the Company's  Common  Stock,  $.001 par
value (the "Common  Stock"),  were issued and  outstanding and held of record by
approximately 340 stockholders.

Revocability of Proxies

     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time  before  its use by  delivering  to the  Secretary  of the
Company a written  notice of revocation or a duly executed proxy bearing a later
date or by  attending  the  meeting and voting in person.  Attending  the Annual
Meeting in and of itself may not constitute a revocation of a proxy.

Voting and Solicitation

     Each  stockholder  is  entitled  to one vote for each  share held as of the
Record Date.  Stockholders  will not be entitled to cumulate  their votes in the
election of directors.

     The cost of  soliciting  proxies will be borne by the Company.  The Company
expects to reimburse brokerage firms and other persons  representing  beneficial
owners of shares for their expense in forwarding  solicitation  material to such
beneficial  owners.  Proxies  may be  solicited  by  certain  of  the  Company's
directors,  officers and regular employees, without additional compensation,  in
person or by telephone or facsimile.

Quorum; Abstentions; Broker Non-Votes

     Votes cast by proxy or in person at the Annual Meeting will be tabulated by
the  Inspector  of  Elections  (the  "Inspector")  with  the  assistance  of the
Company's  Transfer  Agent.  The Inspector will also determine  whether or not a
quorum is present.  Except in certain  specific  circumstances,  the affirmative
vote of a majority of shares present in person or represented by proxy at a duly
held  meeting at which a quorum is present is required  under  Delaware  law for
approval of proposals presented to stockholders.  In general,  Delaware law also
provides  that a quorum  consists of a majority  of shares  entitled to vote and
present or represented by proxy at the meeting.


                                       2

<PAGE>


     The Inspector  will treat shares that are voted  "WITHHELD" or "ABSTAIN" as
being present and entitled to vote for purposes of determining the presence of a
quorum  but will not be  treated  as votes  in  favor of  approving  any  matter
submitted to the  stockholders for a vote. Any proxy which is returned using the
form of proxy  enclosed and which is not marked as to a particular  item will be
voted for the election of the two Class II directors and for the confirmation of
the appointment of the designated independent auditors and, as the proxy holders
deem advisable,  on other matters that may come before the meeting,  as the case
may be with respect to the items not marked.

     If a broker  indicates on the enclosed proxy or its substitute that it does
not have  discretionary  authority as to certain  shares to vote on a particular
matter ("Broker Non-Votes"), those shares will not be considered as present with
respect to that matter.  The Company believes that the tabulation  procedures to
be  followed  by  the  Inspector  are  consistent  with  the  general  statutory
requirements  in Delaware  concerning  voting of shares and  determination  of a
quorum.

Deadline  for Receipt of  Stockholder  Proposals  To Be Presented At 1999 Annual
Meeting

     Proposals that are intended to be presented by  stockholders of the Company
at the 1999 Annual Meeting must be received by the Company no later than October
31, 1998 in order to be considered for inclusion in the proxy statement and form
of proxy relating to that meeting.

Compliance with Section 16(a) of the Securities Exchange Act

     Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended  (the
"Exchange  Act")  requires the  Company's  executive  officers and directors and
persons who own more than ten  percent of a  registered  class of the  Company's
equity  securities to file an initial  report of ownership on Form 3 and changes
in ownership on Form 4 or 5 with the  Securities  and Exchange  Commission  (the
"SEC") and the  National  Association  of  Securities  Dealers,  Inc.  Executive
officers,  directors and greater than ten percent stockholders are also required
by SEC rules to furnish the Company with copies of all Section  16(a) forms they
file.  Based solely on its review of the copies of such forms received by it, or
written  representations  from certain reporting  persons,  the Company believes
that,  with respect to fiscal year 1997, all filing  requirements  applicable to
its officers, directors and ten percent stockholders were complied with.

Share Ownership of Directors, Officers and Certain Beneficial Owners

     The  following  table  sets forth  information  known to the  Company  with
respect to the beneficial  ownership of its Common Stock as of December 31, 1997
for (i) each person who is known by the Company to own beneficially more than 5%
of the Company's Common Stock, (ii) each of the Company's directors and nominees
for director,  (iii) each officer named in the Summary  Compensation Table below
and (iv) all directors, nominees for election and executive officers as a group.
Unless  otherwise  indicated,  officers  and  directors  can be  reached  at the
Company's  principal  executive  offices.  A total of  13,247,226  shares of the
Company's Common Stock were issued and outstanding as of December 31, 1997.


                                       3

<PAGE>

<TABLE>
<CAPTION>


                                                                      Shares Beneficially
Certain Executive Officers,                                               Owned as of
Directors and  5% Stockholders                                      December 31, 1997(1)(2)
                                                               ---------------------------------
                                                                           Number     Percent
                                                                           ------     -------

<S>                                                                     <C>               <C>    
J. P. Morgan & Co. Inc.
   60 Wall Street
   New  York,  NY  10015 ......................................          1,790,300        13.5%

Entities affiliated with Marquette
  Venture Partners (3)
  520 Lake Cook Rd., Suite 450                                           1,251,903         9.5%
  Deerfield,  IL  60015 .......................................  

MBW Venture Partners, L.P. (4)
  James R. Weersing
  365 South Street
  Morristown,  NJ  07960 ......................................          1,442,349        10.8%

State Farm Mutual Automobile
  Insurance Company (5)
  One State Farm Plaza
  Bloomington,  IL  61701 .....................................             887,173        6.6%
Jack  W.  Schuler  (6) ........................................             972,440        7.3%

Henry  T.  Pietraszek .........................................              71,500          *

Michael  K.  Cusack  (7) ......................................              28,810          *

Johnny D. Powers, Ph.D. (8) ...................................              11,667          *

Bernard  O.C.  Questier  (9) ..................................              23,153          *

Pierre  Sice ..................................................                  0           *

Rex  J.  Bates  (10) ..........................................              36,735          *

R.  James  Danehy .............................................             151,224        1.1%

Edward  M.  Giles  (11) .......................................             260,014        2.0%

Thomas M.  Grogan,  M.D.  (12) ................................             170,063        1.3%

John  Patience  (13) ..........................................             297,589        2.2%

James R. Weersing (4)(14) .....................................           1,458,439       10.9%


All directors and executive officers as
a  group  (17  persons) .......................................           3,527,531       25.6%

</TABLE>

- -----------------

*      Less than 1%.

(1)  Except  as  indicated  in the  footnotes  to this  table  and  pursuant  to
     applicable  community  property  laws,  the persons named in the table have
     sole  voting  and  investment  power  with  respect to all shares of Common
     Stock.

(2)  Applicable  percentage of ownership is based on 13,247,226 shares of Common
     Stock  outstanding  as of December 31, 1997 together  with shares  issuable
     pursuant to applicable  options and warrants of such stockholder  which may
     be exercised within 60 days after December 31, 1997. Shares of Common Stock
     subject to options  and/or  warrants  currently  exercisable or exercisable
     within 60 days after December 31, 1997 are deemed outstanding for computing
     the  percentage  ownership  of  the  person  holding  such  options  and/or
     warrants,  but are not deemed  outstanding  for computing the percentage of
     any other person.

(3)  Includes 872,795 shares  beneficially  owned by Marquette Venture Partners,
     L.P.;  247,218 shares  beneficially owned by Marquette Venture Partners II,
     L.P.; and 131,890 shares beneficially owned by MVP II Affiliate Fund, L.P.

(4)  Includes  162,059 shares issuable upon the exercise of warrants held by MBW
     Venture Partners, L.P. Mr. Weersing, a director of the Company, is Managing
     Director of MBW Venture Partners Limited. Mr. 


                                       4

<PAGE>


     Weersing disclaims beneficial ownership of the shares beneficially owned by
     MBW  Venture  Partners,  L.P.  except  to the  extent  of his  proportional
     partnership interest therein.

(5)  Includes  108,893  shares  issuable  upon the exercise of warrants  held by
     State Farm Mutual Automobile Insurance Company.

(6)  Includes  118,917  shares  issuable upon the exercise of warrants and 5,583
     shares issuable upon the exercise of options  exercisable within 60 days of
     December 31, 1997 held by Mr. Schuler;  73,512 shares beneficially owned by
     Mr. Schuler, as custodian for Tanya Eva Schuler; 73,513 shares beneficially
     owned by Mr.  Schuler,  as custodian for Therese Heidi Schuler;  and 73,512
     shares  beneficially  owned by Mr.  Schuler,  as  custodian  for Tino  Hans
     Schuler;  and  10,000  shares  beneficially  owned  by The  Schuler  Family
     Foundation, and 1,250 shares owned by Mrs. Schuler.

(7)  Includes  11,703 shares  issuable upon the exercise of options  exercisable
     within 60 days of December 31, 1997 held by Mr. Cusack.

(8)  Includes  11,667 shares  issuable upon the exercise of options  exercisable
     within 60 days of December 31, 1997 held by Dr. Powers.

(9)  Includes  21,559 shares  issuable upon the exercise of options  exercisable
     within 60 days of December 31, 1997 held by Mr. Questier.

(10) Includes  11,173  shares  issuable  upon the exercise of warrants and 5,583
     shares issuable upon the exercise of options  exercisable within 60 days of
     December 31, 1997 held by Mr. Bates.

(11) Includes  230,903 shares  beneficially  owned by Vertical Fund  Associates,
     L.P.  Also  includes  5,583  shares  issuable  upon the exercise of options
     exercisable  within 60 days of December 31, 1997,  held by Edward M. Giles.
     Also includes 18,372 shares  beneficially owned by Edward M. Giles IRA plus
     5,156 shares issuable upon the exercise of warrants held by Edward M. Giles
     IRA.  Mr.  Giles,  a director of the  Company,  is Chairman of The Vertical
     Group,  Inc.  Mr.  Giles  disclaims  beneficial  ownership  of  the  shares
     beneficially  owned by such entities  affiliated  with The Vertical  Group,
     Inc., except to the extent of his partnership interest therein.

(12) Includes 9,612 shares beneficially owned by Andrew Grogan and 10,612 shares
     beneficially  owned by Emily Grogan  including  7,710  shares  beneficially
     owned by C. Ovens, Inc. (of which 459 shares are issuable upon the exercise
     of warrants  held by C.  Ovens,  Inc.);  and 26,008  shares  issuable  upon
     exercise of options exercisable within 60 days of December 31, 1997 held by
     Dr. Grogan.

(13) Includes  96,689  shares  issuable  upon the exercise of warrants and 5,583
     shares issuable upon the exercise of options  exercisable within 60 days of
     December 31, 1997, held by Mr. Patience as well as 4,800 shares held in the
     name of Mrs. Patience.

(14) Includes 6,209 shares  beneficially  owned by James R. Weersing and Mary H.
     Weersing, Trustees of the Weersing Family Trust U/D/T dated April 24, 1991.
     Also includes 4,298 shares issuable upon the exercise of warrants and 5,583
     shares issuable upon the exercise of options  exercisable within 60 days of
     December 31, 1997, held by Mr. Weersing.


                                       5

<PAGE>


                                 PROPOSAL NO. 1

                              ELECTION OF DIRECTORS

Directors and Nominees for Director

     Pursuant to the Company's  Certificate of  Incorporation,  as amended,  the
Company's Board of Directors  currently consists of seven persons,  divided into
three classes serving  staggered  terms of three years.  Currently there are two
directors  in Class I, two  directors  in Class II and three  directors in Class
III. Two Class II directors are to be elected at the Annual  Meeting.  The Class
III and Class I directors  will be elected at the Company's 1999 and 2000 Annual
Meetings  of  Stockholders,  respectively.  Each of the two  Class II  directors
elected  at the  Annual  Meeting  will hold  office  until the year 2001  Annual
Meeting  of  Stockholders  or until  his  successor  has been duly  elected  and
qualified.

     In the event that any of such persons  becomes  unavailable  or declines to
serve as a director at the time of the Annual  Meeting,  the proxy  holders will
vote the proxies in their  discretion  for any nominee who is  designated by the
current  Board of Directors to fill the vacancy.  It is not expected that any of
the nominees will be unavailable to serve.

     The  names of the two  Class  II  nominees  for  election  to the  Board of
Directors  at the Annual  Meeting,  their ages as of the Record Date and certain
information about them are set forth below. The names of the current Class I and
Class III directors with unexpired  terms,  their ages as of the Record Date and
certain information about them are also set forth below.
<TABLE>
<CAPTION>

                                                                                                     Director
               Name                              Age       Principal Occupation                        Since
- --------------------------------------------  ---------  -------------------------                   --------

Nominees for Class II Directors



<S>                                                 <C>                                                    <C> 
Edward M. Giles ............................        62     Chairman of The Vertical                        1992
                                                           Group, Inc.


Rex Bates ..................................        74     Private Investor                                1996


Continuing Class I Directors-


Henry T. Pietraszek ........................        51     President and Chief Executive Officer of          -
                                                           Ventana Medical Systems, Inc.



James R. Weersing ..........................        58     Managing Director of MBW Venture Partners       1994



Continuing Class III Directors


Thomas M. Grogan, M.D ......................        52     Professor, University of Arizona, College       1985
                                                           of Medicine


John Patience...............................        50     General Partner, Crabtree Partners              1989


Jack W. Schuler.............................        57     General Partner, Crabtree Partners              1991

</TABLE>

     There are no family  relationships among directors or executive officers of
the Company.

     Mr. Giles has served as a director of Ventana  since  September  1992.  Mr.
Giles has served as Chairman of The  Vertical  Group,  Inc.,  a venture  capital
investment  firm,  since January 1989. Mr. Giles was previously  President of F.
Eberstadt & Co., Inc., a securities  firm, and Vice Chairman of Peter B. Cannell
& Co.,  Inc.,  an  investment  management  firm.  He is  currently a director of
McWhorter Technologies, Inc. and Synthetech, Inc. Mr. Giles received a B.S.Ch.E.


                                       6

<PAGE>


in Chemical  Engineering  from  Princeton  University  and an M.S. in Industrial
Management from the Massachusetts Institute of Technology.

     Mr.  Bates has served as a director of Ventana  since  April of 1996.  From
August 1991 to May 1995, Mr. Bates served on the Board of Directors of Twentieth
Century  Industries  and was a member of its  compensation  committee.  Prior to
Twentieth Century Industries, Mr. Bates served as the Vice-Chairman of the Board
of Directors of the State Farm Mutual Automobile  Insurance  Company.  Mr. Bates
also served as State  Farm's Chief  Investment  Officer.  In March of 1991,  Mr.
Bates retired from State Farm.  Prior to Mr. Bates'  employment with State Farm,
he was a partner in the investment firm of Stein, Roe & Farnham in Chicago.  Mr.
Bates received a B.S. and an M.S. from the University of Chicago.

     Mr. Pietraszek became President,  Chief Executive Officer and a director in
March 1997. Prior to joining the Company, Mr. Pietraszek served as President and
Chief Executive Officer of Biostar,  Inc., a medical  diagnostic  company.  From
19975 to 1994, Mr.  Pietraszek  held a variety of executive  positions at Abbott
Laboratories  and Takeda  Chemical  Industries.  From 1982 to 1986, he served as
President  of  Dainabot  K.K.,  a joint  venture  between  Abbott and  Dainippon
Pharmaceutical  Company of Japan and from 1980 to 1982 he was Vice  President of
Field Service Operations for Abbott's Diagnostic  Division.  He is a director of
Specialty Laboratories.  Mr. Pietraszek received a B.S. in Marketing from Gannon
University.

     Mr. Weersing has served as a director of Ventana since October 1994.  Since
1984,  Mr.  Weersing  has been a Managing  Director of MBW Venture  Partners,  a
venture  capital  investment  firm. Mr. Weersing has also served as President of
JRW  Technology,  Inc., a consulting  firm. Mr. Weersing served as a director of
Circadian,  Inc., an asthma dosage management company,  from December 1993 until
January  1996.  Circadian  filed  a  petition  under  Chapter  7 of the  federal
bankruptcy laws in January 1996. Mr. Weersing received an B.S.M.E. and an M.B.A.
from Stanford University.

     Mr.  Schuler  has served as a director  of Ventana  since April 1991 and as
Chairman of the Board of Directors  since  November  1995.  Mr. Schuler has been
Chairman of the Board of Directors of  Stericycle,  Inc., a specialized  medical
waste  management  company,  since March 1990.  Mr. Schuler is also a partner in
Crabtree  Partners,  a Chicago  based  venture  capital  firm.  Prior to joining
Stericycle, Mr. Schuler held various executive positions at Abbott from December
1972 through August 1989, serving most recently as President and Chief Operating
Officer.  He is currently a director of  Medtronic,  Inc.,  Somatogen,  Inc. and
Chiron Corporation.  Mr. Schuler received a B.S. in Mechanical  Engineering from
Tufts University and an M.B.A. from Stanford University.

     Dr. Grogan is a founder,  a director and Chairman  Emeritus of Ventana.  He
has served as a director  since the  founding of the Company in June 1985 and as
Chairman  of the  Board of  Ventana  from  June  1985 to  November  1995.  He is
currently a professor  of  pathology at the  University  of Arizona,  College of
Medicine, where he has taught since 1979. He received a B.A. in Biology from the
University  of Virginia and an M.D. from George  Washington  School of Medicine.
Dr. Grogan completed a post-doctorate fellowship at Stanford University.

     Mr.  Patience  has served as a director  of  Ventana  since July 1989.  Mr.
Patience was a co-founder and served as a General  Partner of Marquette  Venture
Partners, a venture capital investment firm, from January 1988 until March 1995.
Since April  1995,  Mr.  Patience  has been a partner in  Crabtree  Partners,  a
Chicago-based venture capital firm. Mr. Patience was previously a partner in the
consulting firm of McKinsey & Co.,  specializing in health care. He is currently
a director of TRO Learning,  Inc. and Stericycle,  Inc. Mr. Patience  received a
B.A. in Liberal Arts and an L.L.B. from the University of Sydney,  Australia and
an M.B.A. from the University of Pennsylvania Wharton School of Business.

                                       7

<PAGE>


     Board Meetings, Committees and Director Compensation

     The Board of Directors of the Company held six meetings during the
fiscal year ended December 31, 1997.

     The Board of Directors has an Audit Committee and a Compensation Committee.
It does not have a nominating  committee or a committee performing the functions
of a nominating  committee.  From time to time, the Board has created various ad
hoc committees for special purposes. No such committee is currently functioning.

     The Audit Committee consists of directors James Weersing, John Patience and
Rex Bates.  The Audit  Committee is  responsible  for  reviewing the results and
scope of the audit and other  services  provided  by the  Company's  independent
auditors. The Audit Committee held two meetings in the last fiscal year.

     The  Compensation  Committee  consists of  directors  Jack  Schuler,  James
Weersing  and  Edward  Giles.  The  Compensation  Committee  reviews  and  makes
recommendations to the Board concerning salaries and incentive  compensation for
executive  officers  and certain  employees  of the  Company.  The  Compensation
Committee  held six meeting during the last fiscal year. The President and Chief
Executive  Officer of the Company  participates  fully with all other  committee
members in  recommending  salaries and  incentive  compensation  to the board of
directors, except that he does not participate in committee proceedings relating
to his salary and compensation.

Compensation of Directors

     Directors of the Company do not receive  cash for services  they provide as
directors.  From time to time,  certain  directors  who are not employees of the
Company  have  received  grants of options to purchase  shares of the  Company's
Common Stock.  Under the 1996 Director  Option Plan, each  nonemployee  director
will be granted a nonstatutory  option to purchase an amount of shares of Common
Stock of the  Company  equal to  5,000  shares  multiplied  by a  fraction,  the
numerator  of which  shall be $15.00 and the  denominator  of which shall be the
fair  market  value of one share of the  Company's  Common  Stock on the date of
grant.  The  Company  does not provide  additional  compensation  for  committee
participation or special assignments of the Board of Directors.

Vote Required

     The two nominees  receiving the highest number of affirmative  votes of the
shares  entitled  to vote on this  matter  shall  be  elected  as the  Class  II
directors.

     THE COMPANY'S BOARD OF DIRECTORS  UNANIMOUSLY  RECOMMENDS  VOTING "FOR" THE
NOMINEES SET FORTH HEREIN.

                                       8

<PAGE>


                                 PROPOSAL NO. 2

                 APPROVAL OF AMENDMENT OF 1996 STOCK OPTION PLAN

     The Company's Board of Directors and stockholders  have previously  adopted
and approved the Company's 1996 Stock Option Plan (the "Option  Plan").  A total
of 1,000,000  shares of Common Stock are presently  reserved for issuance  under
the Option Plan. In January 1998,  the Board of Directors  approved an amendment
to the Option  Plan,  subject to  stockholder  approval,  to increase the shares
reserved for issuance thereunder by 750,000 shares, bringing the total number of
shares issuable under the Option Plan to 1,750,000.

     As of January 29, 1998,  less than 1,000 shares were  available  for future
issuance under the Option Plan.

     At the Annual Meeting, the stockholders are being requested to consider and
approve the  proposed  amendment  to the Option  Plan to increase  the number of
shares of Common  Stock  reserved  for issuance  thereunder  by 750,000  shares,
bringing the total number of shares issuable under the Option Plan to 1,750,000.
The Board  believes that the  amendment  will enable the Company to continue its
policy of widespread employee stock ownership as a means to motivate high levels
of performance and to recognize key employee accomplishments.

     The Plan  authorizes  the Board of  Directors  to grant  stock  options  to
eligible  employees,  directors  and  consultants  of the  Company.  The Plan is
structured to allow the Board of Directors  broad  discretion in creating equity
incentives  in  order  to  assist  the  Company  in  attracting,  retaining  and
motivating  the best  available  personnel  for the  successful  conduct  of the
Company's business.  The Company has had a longstanding  practice of linking key
employee  compensation  to corporate  performance  because it believes that this
increases  employee  motivation to improve  shareholder  value. The Company has,
therefore, consistently included equity incentives as a significant component of
compensation  for a broad range of the  Company's  employees.  This practice has
enabled  the  Company to attract  and retain  the talent  that it  continues  to
require.

     The Board of Directors  believes  that the remaining  shares  available for
grant under the Plan are  insufficient  to  accomplish  the purposes of the Plan
described above. The Company anticipates there will be a need to hire additional
technical  or  management  employees,  and it will be  necessary to offer equity
incentives  to attract  and  motivate  these  individuals,  particularly  in the
current extremely  competitive job market.  In addition,  in order to retain the
services of valuable employees as the Company matures and its employee base grow
larger, it will be necessary to grant additional options to current employees as
older options become fully vested.

     For a  description  of the  principal  features  of the  Option  Plan,  see
"Exhibit A"- Description of 1996 Stock Option Plan."

Vote Required

     The approval of the amendment to the Option Plan  requires the  affirmative
vote of a majority of the votes cast on the proposal at the Annual Meeting.

     THE COMPANY'S BOARD OF DIRECTORS  UNANIMOUSLY  RECOMMENDS  VOTING "FOR" THE
AMENDMENT  OF THE OPTION  PLAN TO  INCREASE  THE NUMBER OF SHARES  RESERVED  FOR
ISSUANCE THEREUNDER.

                                       9

<PAGE>


                                 PROPOSAL NO. 3

             RATIFICATION OF THE APPOINTMENT OF INDEPENDENT AUDITORS

     The  Board  of  Directors  has  selected  Ernst  & Young  LLP,  independent
auditors,  to audit the financial  statements of the Company for the fiscal year
ending  December  31,  1998  and  recommends  that  the  stockholders  vote  FOR
confirmation  of  such  selection.  In the  event  of a  negative  vote  on such
ratification,   the  Board  of  Directors   will   reconsider   its   selection.
Representatives  of Ernst & Young LLP are  expected  to be present at the Annual
Meeting  with the  opportunity  to make a statement if they desire to do so, and
are expected to be available to respond to appropriate questions.

     THE COMPANY'S BOARD OF DIRECTORS  UNANIMOUSLY  RECOMMENDS  VOTING "FOR" THE
RATIFICATION  OF  THE  APPOINTMENT  OF  ERNST  &  YOUNG  LLP  AS  THE  COMPANY'S
INDEPENDENT AUDITORS FOR THE FISCAL YEAR ENDING DECEMBER 31, 1998.

                                       10

<PAGE>


                             EXECUTIVE COMPENSATION

Compensation Tables

     Summary   Compensation  Table.  The  following  table  sets  forth  certain
compensation  paid by the  Company to the Chief  Executive  Officer and the four
other most highly  compensated  executive  officers of the Company for  services
rendered during each of the fiscal years ended December 31, 1995, 1996 and 1997:

                           Summary Compensation Table
<TABLE>
<CAPTION>
                                                                                       Long-Term
                                                                                      Compensation
                                                                                         Awards
                                                                             -----------------------------
                                                                                Restricted     Securities        All Other
                                                     Annual Compensation           Stock       Underlying         Annual
Name and Principal Position           Year        Salary($)       Bonus($)       Awards($)       Options      Compensation($)
- ---------------------------           ----        ---------       --------       ---------       -------      ---------------
                                                
<S>                                   <C>          <C>           <C>                <C>          <C>             <C>
Henry T. Pietraszek                   1997         167,942          --              --          350,000             707 (1)
  President  and Chief  Executive     1996              --          --              --               --              --
  Officer                             1995              --          --              --               --              --

Bernard O. C. Questier (3)            1997         150,000          --              --           10,000           8,800 (2)
  Vice    President,     European     1996         137,500       7,500 (4)          --               --           8,067 (2)
  Operations                          1995              --          --                           36,956          57,200 (5)
                                                
Pierre H. Sice                        1997         122,963                          --           55,000           8,264 (1)
  Vice President, Finance and Chief   1996              --          --              --               --              --
  Financial Officer and Secretary     1995              --          --              --               --              --

Johnny D. Powers, Ph.D.               1997         118,375          --              --           15,000              --
   Vice President, Operations         1996          16,154      15,000 (6)          --           35,000          23,872 (1)
                                      1995              --          --              --               --              --
                                                
Michael K. Cusack                     1997         102,268          --              --            7,000              --
  Vice President, International       1996         100,130          --              --               --              --
                                      1995         100,054
- -----------------
</TABLE>

(1)  Relocation Expense

(2)  Automobile allowance

(3)  Mr. Questier  signed an employment  contract with the Company in October of
     1995 and  began  working  at the  Company  in  February  1996.  His  annual
     compensation is set at $150,000 and his salary is fixed to the French Franc
     to protect against  currency  fluctuations  should the United States Dollar
     depreciate  relative to the French  Franc;  however,  if the United  States
     Dollar  appreciates  relative to the French Franc,  Mr.  Questier's  salary
     shall remain unchanged.

(4)  Mr.  Questier  received a one-time  nonrecurring  $7,500  bonus in 1996 for
     signing his  employment  contract  in October of 1995 and  meeting  certain
     other conditions.

(5)  Consists of relocation  expenses of $55,000  associated with Mr. Questier's
     move from Germany to France, and a $2,200 automobile allowance.

(6)  Mr. Powers was offered a sign-on  bonus of $15,000 in  connection  with his
     joining the company.

                                       11

<PAGE>



     Option  Grants  in  Last  Fiscal  Year.  The  following  table  sets  forth
information  with respect to each grant of stock  options made during the fiscal
year ended  December  31, 1997 to each  executive  officer  named in the Summary
Compensation Table above:

<TABLE>
<CAPTION>
                                        Option Grants in Fiscal 1997

                                               Individual Grants                    
                               ------------------------------------------------     Potential Realizable
                               Number of                                              Value at Assumed
                               Securities  % of Total     Exercise                  Annual Rates of Stock
                               Underlying    Options      or Base                    Price Appreciation
                               Options       Granted       Price     Expiration      for Option Term(4)
                                                                                  -------------------------
         Name                  Granted(1)  In 1997(2)    ($/Sh)(3)      Date         5%($)        10%($)
         ----                  ----------  ----------    ---------      ----         -----       ------

         <S>                      <C>          <C>         <C>          <C>        <C>          <C>       
         Henry T. Pietraszek      350,000      24.4%       $12.25       4/18/07    $2,696,386   $6,833,171
         Bernard  O. C.Questier    10,000       0.7%       $12.25       4/18/07    $   77,040   $  195,233
         Pierre H. Sice            55,000       3.8%       $12.25       4/18/07    $  423,718   $1,073,784
         Johnny D.Powers,Ph.D.     15,000       1.0%       $12.25       4/18/07    $  115,559   $  292,850
         Michael K. Cusack          7,000       0.5%       $12.25       4/18/07    $   53,928   $  136,663
                                                                                  
</TABLE>
- -----------------------


(1)  Options were granted  under the  Company's  1988 Stock Option Plan or under
     the 1996 Stock Option Plan.  These  generally vest over four years from the
     date of grant,  except for Mr.  Pietraszek's  options which vest over seven
     years from the date of grant.

(2)  Based on an aggregate of  1,436,460  options  granted by the Company in the
     year ended December 31, 1997 under the Company's  stock option plans to all
     employees of and consultants to the Company,  including the Chief Executive
     Officer and four other most highly compensated officers.

(3)  The  exercise  price per share of each  option was equal to the fair market
     value of the Common Stock on the date of grant.

(4)  The 5% and 10% assumed annual rates of compounded stock price  appreciation
     are mandated by rules of the Securities and Exchange Commission.  There can
     be no assurance  provided to any  executive  officer or any other holder of
     the Company's  securities that the actual stock price appreciation over the
     10-year  option  term will be at the  assumed  5% and 10%  levels or at any
     other  defined  level.   Unless  the  market  price  of  the  Common  Stock
     appreciates over the option term, no value will be realized from the option
     grants made to the executive officers.

     Aggregate  Option Exercises in Last Fiscal Year and Fiscal Year-End Values.
The following table sets forth, for each of the executive  officers named in the
Summary  Compensation Table above,  information with respect to each exercise of
stock  options  during the fiscal year ended  December 31, 1997 and the value of
unexercised options at December 31, 1997.

                                       12

<PAGE>


         Aggregate Option Exercises in Fiscal 1997 and Year-End Values
<TABLE>
<CAPTION>
                                                       Number of Securities
                                                            Underlying                 Value of Unexercised
                            Shares                      Unexercised Options            In-the-Money Options
                          Acquired       Value         at December 31, 1997          at December 31, 1997(1)
                              on
   Name                   Exercise(#)    Realized($)   Exercisable   Unexercisable    Exercisable    Unexercisable
   ----                   -----------    -----------   -----------   -------------    -----------    -------------
   <S>                        <C>           <C>         <C>              <C>             <C>            <C>      
   Henry T. Pietraszek        --            --             --            350,000           --           1,050,000
   Bernard O.C. Questier      --            --          20,019            26,938         288,498          274,097
   Pierre H. Sice             --            --             --             55,000           --             165,000
   Johnny   D.   Powers,      --            --          10,209           39,791            --              45,000
   Ph.D.
   Michael K. Cusack          --            --          10,471           13,159          150,900          109,759
</TABLE>

(1)  The value of  "in-the-money"  stock options  represents the positive spread
     between the exercise  price of stock  options,  which ranges from $0.84 per
     share to $17.00  per share,  and the fair  market  value for the  Company's
     Common  Stock of $15.25 per share as of December  31,  1997,  which was the
     closing price of the Company's Common Stock on December 31, 1997.

Employment Agreements

     The Company has an employment  agreement  with Bernard O.C.  Questier,  its
Vice  President  of  European  Operations.  The  agreement  provides  for annual
compensation of $150,000,  which is fixed to the French Franc to protect against
currency fluctuations should the United States Dollar depreciate relative to the
French Franc;  however, if the United States Dollar appreciates  relative to the
French Franc, Mr. Questier's  salary shall remain unchanged.  The agreement also
provides for, in the event of Mr. Questier's termination, continued compensation
through the quarter in which notice of  termination is given plus one additional
full  quarter.  The  agreement  does  not  provide  for  any  specified  term of
employment. The Company currently has no employment contracts or agreements with
any of the other  officers named in the Summary  Compensation  Table or with any
other person.

Compensation  Committee  Interlocks and Insider  Participation  in  Compensation
Decisions

     The  Compensation  Committee of the Board of Directors  consists of Jack W.
Schuler,  James Weersing and Edward M. Giles. The  Compensation  Committee makes
recommendations  to the Board of Directors  concerning  salaries  and  incentive
compensation  for employees of and  consultants to the Company,  except that the
Compensation  Committee  has full power and  authority to grant stock options to
the Company's  executive officers under the Company's 1996 Stock Option Plan and
the Company's 1998 Stock Option Plan.

                                       13

<PAGE>


                       BOARD COMPENSATION COMMITTEE REPORT
                            ON EXECUTIVE COMPENSATION

     The  following  is  provided  to   stockholders   by  the  members  of  the
Compensation Committee of the Board of Directors:

     The  Compensation  Committee of the Board of Directors  (the  "Committee"),
comprised of three outside  directors,  is responsible for the administration of
the Company's  compensation  programs.  These  programs  include base salary for
executive  officers  and  both  annual  and  long-term  incentive   compensation
programs.  The  Company's  compensation  programs  are  designed  to  provide  a
competitive  level  of total  compensation  and  include  incentive  and  equity
ownership  opportunities  linked to the Company's  performance  and  stockholder
return.

Compensation Philosophy

     The design  and  implementation  of the  Company's  executive  compensation
programs are based on a series of guiding  principles derived from the Company's
values, business strategy and management  requirements.  These principles may be
summarized as follows:

     o    Align the financial  interests of the management team with the Company
          and its stockholders;

     o    Attract,  motivate and retain  high-caliber  individuals  necessary to
          increase total return to stockholders;

     o    Provide a total  compensation  program where a significant  portion of
          pay is linked to  individual  achievement  and  short-  and  long-term
          Company performance; and

     o    Emphasize  reward for performance at the individual,  team and Company
          levels.

Compliance with Internal Revenue Code Section 162(m)

     The Committee has considered the potential  impact of Section 162(m) of the
Internal  Revenue Code adopted under the Federal Revenue  Reconciliation  Act of
1993. Section 162(m) disallows a tax deduction for any publicly held corporation
for individual  compensation exceeding $1 million in any taxable year for any of
the named executive  officers,  unless  compensation is performance based. Since
the targeted cash  compensation of each of the named executive  officers is well
below the $1 million  threshold  and the  Committee  believes  that any  options
granted under the Company's stock option plan will meet the requirement of being
performance  based under the transition  provisions  provided in the regulations
under Section 162(m), the Committee believes that Section 162(m) will not reduce
the tax deduction  available to the Company.  The Company's policy is to qualify
to the extent reasonable its executive officers'  compensation for deductibility
under applicable tax laws.

Compensation Program

     The Company's  executive  compensation  program has three major components,
all of which are  intended to attract,  retain and motivate  executive  officers
consistent  with the principles set forth above.  The Committee  considers these
components of  compensation  individually as well as collectively in determining
total compensation for executive officers.

     1. Base salary.  Each fiscal year the Committee  establishes  base salaries
for  individual  executive  officers  based  upon (i)  industry  and peer  group
surveys, (ii) responsibilities,  scope and complexity of each position and (iii)
performance   judgments  as  to  each  individual's  past  and  expected  future
contributions.  The  Committee  reviews  with the Chief  Executive  Officer  and
approves,  with  appropriate  modifications,  an annual base salary plan for the
Company's  executive  officers  other  than the  Chief  Executive  Officer.  The
Committee reviews and fixes the base salary of the Chief Executive Officer based
on similar competitive  compensation data and the Committee's  assessment of his
past performance and its expectations as to his future  contributions in leading
the Company.

     2. Annual cash  (short-term)  incentives.  Annual cash  incentives  will be
established  to  provide a direct  linkage  between  individual  pay and  annual
corporate  performance.  Target  annual  bonus  awards will be  established  for
executive officer positions based upon industry and peer group surveys and range
from  5% to 25% of  base  salary,  with 

                                       14

<PAGE>


25% for the chief  executive  officer  position.  Each  officer who served in an
executive  capacity  during the last fiscal year,  including the Chief Executive
Officer,  received a bonus for such service in the form of stock options, except
one officer who also received a cash bonus. In establishing bonus amounts in the
future, the Committee will primarily  consider the financial  performance of the
Company  measured  in terms of  revenue  growth  and  growth  in  earnings,  and
secondarily  consider the  performance  of each officer in his or her respective
area of accountability. Each officer will establish operating objectives for the
functional  area of the  business  for  which  they take  responsibility  at the
beginning of the  Company's  fiscal year.  At the end of the year,  they will be
rated on the attainment of those objectives.  Each officer may receive a portion
or the full amount of their targeted annual performance based bonus.

     3.  Equity  based  incentive  compensation.  Long-term  incentives  for the
Company's  employees are provided under the Company's  stock option plans.  Each
fiscal year, the Committee  considers the  desirability of granting to executive
officers long-term incentives in the form of stock options.  These option grants
are  intended  to motivate  the  executive  officers  to manage the  business to
improve long-term Company  performance and align the financial  interests of the
management team with the Company and its stockholders. The Committee established
the  grants  of stock  options  to  executive  officers  (other  than the  Chief
Executive  Officer) in the Last Fiscal Year,  based upon a review with the Chief
Executive  Officer of  proposed  individual  awards,  taking into  account  each
officer's  scope of  responsibility  and  specific  assignments,  strategic  and
operational   goals   applicable   to  the  officer,   anticipated   performance
requirements  and  contributions of the officer and competitive data for similar
positions.   The  Committee   independently   reviewed  these  same  factors  in
determining  the option  grant to Mr.  Pietraszek  as Chief  Executive  Officer.
During the Last Fiscal Year,  an option award of 350,000  shares of Common Stock
was granted to Mr.  Pietraszek,  which  vests over a  seven-year  period.  Stock
options  granted to  executive  officers  typically  provide for vesting  over a
four-year period.

                              Respectfully submitted,

                               Jack W. Schuler
                               James R. Weersing
                               Edward M. Giles

     The  foregoing  Compensation  Committee  Report  shall  not be deemed to be
"soliciting  material" or to be "filed" with the SEC, nor shall such information
be  incorporated by reference into any future filing under the Securities Act of
1933, as amended (the  "Securities  Act"),  or the Exchange  Act,  except to the
extent the Company specifically incorporates it by reference into such filing.


                                       15
<PAGE>


                             STOCK PERFORMANCE GRAPH

     The following graph compares the cumulative total return to stockholders of
the  Company's  Common  Stock at December 31, 1997 since July 26, 1996 (the date
the Company first became subject to the reporting  requirements  of the Exchange
Act) to the  cumulative  total  return over such period of (i) the Nasdaq  Stock
Market Composite Index, (ii) the Russell 2000 Index and (iii) the Dillon, Read &
Co. Medical  Diagnostic  Index. The graph assumes the investment of $100 on July
26, 1996 in the  Company's  Common Stock and each of such indices (from July 28,
1996) and reflect the change in the market price of the  company's  Common Stock
relative  to the noted  indices at  December  31,  1997 and not for any  interim
period.  The  performance  shown is not  necessarily  indicative of future price
performance.


                     COMPARISON OF CUMULATIVE TOTAL RETURN*

    [THE FOLLOWING WAS REPRESENTED AS A LINE GRAPH IN THE PRINTED MATERIAL.]


<TABLE>
<CAPTION>
                                  7/96           9/96           12/96          3/97           6/97           9/97          12/97
                                  ----           ----           -----          ----           ----           ----          -----

<S>                             <C>             <C>            <C>            <C>            <C>            <C>            <C>    
VENTANA                         $1000.00        $185.00        $145.00        $140.00        $123.75        $161.25        $152.50

NASDAQ US ($)                   $1000.00        $113.68        $119.27        $112.80        $133.48        $156.06        $146.36

RUSSELL 2000 ($)                $1000.00        $109.62        $114.75        $108.41        $125.43        $143.61        $138.30
                                
DILLON, READ & CO.MED. ($)      $1000.00        $110.87        $113.77        $115.94        $127.54        $152.17        $143.48
</TABLE>


     The  information  contained  in the Stock  Performance  Graph  shall not be
deemed to be  "soliciting  material" or to be filed with the SEC, nor shall such
information  be  incorporated  by  reference  into any future  filing  under the
Securities  Act  or  the  Exchange  Act,   except  to  the  extent  the  Company
specifically incorporates it by reference into such filing.


                                       16
<PAGE>


                              CERTAIN TRANSACTIONS

     In April and May 1996,  the Company sold an aggregate of 646,664  shares of
Common Stock to Jack Schuler, the Company's Chairman,  John Patience, a director
of the Company,  and venture  capital funds  affiliated  with Marquette  Venture
Partners  ("Marquette"),  a principal  stockholder of the Company, at a purchase
price of $1.62 per share.  Messrs.  Schuler and Patience paid the purchase price
for their  shares 10% in cash and 90% through a full  recourse  promissory  note
secured by the  underlying  shares of Common Stock.  Marquette paid the purchase
price for their  shares in cash.  These  stock  purchases  were  approved by the
Company's Board of Directors in principle in January 1996 and the specific terms
of the stock  purchases  were approved by the Board of Directors on February 23,
1996.  The  purchase  price of $1.62 per share  was  determined  by the Board of
Directors  of the Company in January  1996 and equals the fair  market  value of
Company's  Common Stock as of such date,  as  determined  by the board.  Messrs.
Schuler and Patience were provided with the opportunity to purchase these shares
in  connection   with  (i)  their  efforts  and  assistance  in  completing  the
acquisition  of  BioTek  Solutions,  Inc.  and  assisting  management  with  the
integration of the companies,  (ii) Mr. Schuler's  decision to serve as Chairman
of the Board of Directors and (iii) Mr. Schuler's and Mr. Patience's devotion of
a significant portion of their work time to the Company's business.  In February
1998,  Messrs.  Schuler and Patience each fully paid the promissory notes issued
in connection with their purchase of the shares.

     On  November  13,  1997,  the  Company's  Board  of  Directors  unanimously
approved,  with  Messrs.  Patience  and  Schuler  abstaining,  a renewal  of the
foregoing arrangement. Under this arrangement, Messrs. Schuler and Patience each
received options for 150,000 shares of Company Common Stock.  These options were
issued on the basis that Messrs. Patience and Schuler would devote a significant
percentage  of their work time to the  Company's  business and that Mr.  Schuler
would serve as Chairman of the Company's Board of Directors. The options vest on
a cumulative monthly basis over 24 months commencing  February 26, 1998 and have
an exercise price of $12.625 per share,  which is equal to the fair market value
of the Company's Common Stock on the date of grant.

     In February 1997, the Company  repaid certain  outstanding  notes issued in
connection  with  the  acquisition  of  BioTek  Solutions,  Inc.  and a  related
financing  transaction.  These notes were originally issued between February and
May 1996.  Under the terms of the  notes,  no  interest  would be payable if the
principal of the notes was repaid in full on or prior to February 26, 1997.  The
notes were repaid prior to such date, and, accordingly,  no interest was paid on
the  notes.  Holders  of the  notes  included  the  following  5%  stockholders,
directors and entities  affiliated with directors:  MBW Venture Partners,  L.P.,
Jack W.  Schuler,  certain  entities  with whom Edward M. Giles was  affiliated,
State Farm Mutual Automobile Insurance Company, John Patience,  Rex Bates, James
R. Weersing, and Thomas M. Grogan, M.D.


                                       17
<PAGE>


                                  OTHER MATTERS

     The Company  knows of no other  matters to be submitted to the meeting.  If
any other matters  properly come before the meeting,  it is the intention of the
persons  named  in the  accompanying  form of  proxy  to vote  the  shares  they
represent as the Board of Directors may recommend.


     THE  COMPANY  WILL MAIL  WITHOUT  CHARGE TO ANY  STOCKHOLDER  UPON  WRITTEN
REQUEST A COPY OF THE  COMPANY'S  ANNUAL  REPORT  ON FORM  10-K,  INCLUDING  THE
FINANCIAL STATEMENTS,  SCHEDULES AND A LIST OF EXHIBITS. REQUESTS SHOULD BE SENT
TO INVESTOR RELATIONS, VENTANA MEDICAL SYSTEMS, INC., 3865 NORTH BUSINESS CENTER
DRIVE, TUCSON, ARIZONA 85705.






                                                          THE BOARD OF DIRECTORS


Dated:   March 31, 1998


<PAGE>

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                         VENTANA MEDICAL SYSTEMS, INC.
                      1998 ANNUAL MEETING OF STOCKHOLDERS
                                 April 30, 1998

     The  undersigned  stockholder of VENTANA MEDICAL  SYSTEMS,  INC. a Delaware
corporation,  hereby  acknowledges  receipt of the  Notice of Annual  Meeting of
Stockholders and Proxy Statement, each dated March 31, 1998, and hereby appoints
Henry  T.  Pietraszek,   Pierre  H.  Sice,  or  either  of  them,   proxies  and
attorneys-in-fact, with full power to each of substitution, on behalf and in the
name of the undersigned, to represent the undersigned at the 1998 Annual Meeting
of Stockholders of VENTANA MEDICAL SYSTEMS, INC. to be held on April 30, 1998 at
10:00 a.m.  local time, at the Arizona Inn,  Tucson Room,  2200 East Elm Street,
Tucson,  Arizona 85719, and at any adjournment or adjournments  thereof,  and to
vote all shares of Common Stock which the undersigned  would be entitled to vote
if then and there personally present, on the matters set forth below.

1.   ELECTION OF CLASS II DIRECTORS

                       [_] FOR all nominees listed below          [_] WITHHOLD
                           (except as indicated)

     IF YOU  WISH TO  WITHHOLD  AUTHORITY  TO VOTE FOR ANY  INDIVIDUAL  NOMINEE,
     STRIKE A LINE THROUGH THAT NOMINEE'S NAME IN THE LIST BELOW:

                          Edward M. Giles; Rex Bates.

2.   Proposal to approve the amendment to the 1996 Stock Option Plan to increase
     the number of shares reserved for issuance thereunder from 1,000,000 shares
     to 1,750,000 shares

                   [_] FOR         [_] AGAINST          [_] ABSTAIN

3.   Proposal to ratify the  appointment of Ernst & Young LLP as the independent
     public accountants of the Company for the year ending December 31, 1998:

                   [_] FOR         [_] AGAINST          [_] ABSTAIN

                (continued, and to be signed on the reverse side)
                    
<PAGE>

                        (continued from the other side)
                        

     This  Proxy  will be voted as  directed  or, if no  contrary  direction  is
indicated,  will  be  voted  for the  election  of the two  nominated  Class  II
directors,  for the  amendment of the Amended 1996 Stock Option Plan to increase
the number of shares reserved for issuance  thereunder,  for the ratification of
the appiontment of Ernst & Young LLP as independent public  accountants,  and as
said proxies deem  advisable on such other  matters as may properly  come before
the meeting.


                                                 Dated ___________________, 1998

                                                 -------------------------------
                                                             Signature

                                                 -------------------------------
                                                             Signature

                                        (This Proxy should be marked, dated and
                                        signed by the stockholder(s)) exactly as
                                        his, her or its name appears hereon, and
                                        returned   promptly   in  the   enclosed
                                        envelope. Persons signing in a fiduciary
                                        capacity  should so indicate.  If shares
                                        are  held  by  joint tenants  or as com-
                                        munity property, both should sign.)





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