ANTEX BIOLOGICS INC
SC 13D/A, 2000-06-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                  SCHEDULE 13D


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                                (Amendment No. 3)


                              ANTEX BIOLOGICS INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                          Common Stock, $.01 Par Value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   03672W-100
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                Edgar B. Cale III, SmithKline Beecham Corporation
                   One Franklin Plaza, Philadelphia, PA 19102
                             Telephone 215-751-3027
--------------------------------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)


                                   May 5, 2000
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with the statement [ ]. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                                                                          Page 1

<PAGE>

                                  SCHEDULE 13D

CUSIP NO. 03672W-100                                           Page 2 of 5 Pages


This  Amendment No. 3 further amends and  supplements  the Statement on Schedule
13D  electronically  filed with the  Securities  and  Exchange  Commission  (the
"Commission")  on May 17, 1996 (the "Initial  Statement") by SmithKline  Beecham
Biologicals  Manufacturing  s.a.  ("SBBM")  and  amended  on  June 5,  1996  and
September 24, 1999.

The undersigned hereby amends and supplements Item 5 of the Initial Statement to
include  the  following  information  (capitalized  terms  used  herein  without
definition shall have the same meaning as set forth in the Initial Statement).










                                                                          Page 2

<PAGE>

                                  SCHEDULE 13D

CUSIP NO. 03672W-100                                           Page 3 of 5 Pages

--------------------------------------------------------------------------------

1   NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      SmithKline Beecham Biologicals Manufacturing s.a.

--------------------------------------------------------------------------------
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                               (a) [ ]
                                                               (b) [ ]
--------------------------------------------------------------------------------
3   SEC USE ONLY

--------------------------------------------------------------------------------
4   SOURCE OF FUNDS*

      WC
--------------------------------------------------------------------------------
5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
    TO ITEMS 2(D) OR 2(E)                                             [ ]

--------------------------------------------------------------------------------
6   CITIZENSHIP OR PLACE OF ORGANIZATION

      Belgium
--------------------------------------------------------------------------------
                7   SOLE VOTING POWER
  NUMBER OF
   SHARES               7,956,657
BENEFICIALLY
  OWNED BY      -------------------------------------------------
    EACH        8   SHARED VOTING POWER
  REPORTING
   PERSON               None
    WITH
                -------------------------------------------------
                9   SOLE DISPOSITIVE POWER

                        7,956,657
-----------------------------------------------------------------
               10   SHARED DISPOSITIVE POWER

                        None
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      7,956,657
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
     CERTAIN SHARES*                                               [ ]

--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      15.14%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON*

      CO
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                                                          Page 3

<PAGE>

                                                               Page 4 of 5 Pages



Item 5.  Interest in Securities of the Issuer.

     Item 5 of Schedule 13D is hereby amended to add the following information:

       (a)  Amount and Percent Beneficially Owned

            Registered Name             Class        No. of Shares    Percent

            SmithKline Beecham
            Biologicals
            Manufacturing s.a.       Common Stock      7,956,657       15.14%


       (b)  Power to Vote and Dispose of Shares

                SBBM has sole voting and investment power to vote and to dispose
of all the shares of Common Stock identified in subparagraph (a) above.

       (c)  Transactions in the Class of Securities

            On  May 5, 2000, SBBM received  3,495,204 shares of Issuer's  Common
Stock upon the  cashless  exercise of warrants to purchase  3,865,769  shares of
Issuer's Common Stock at an exercise price of $0.37 per share.

            The  shares of Common Stock  identified in  Item 5(a) above  include
866,189  shares  issuable  upon  exercise  of  warrants  related to  incremental
research and development  funding provided to the Issuer by SBBM. The Issuer has
advised SBBM of its belief that those warrants are not exercisable  based on the
date the funding was received.  The Issuer and SBBM are in  discussions  on this
matter and the ultimate outcome is unknown.

       (d)  Right to Receive or Power to Direct the Receipt of  Dividends  from,
            or Proceeds from the Sale of, such Securities

            None.





                                                                          Page 4

<PAGE>

                                                               Page 5 of 5 Pages

                                    SIGNATURE

              After  reasonable  inquiry  and to the  best of my  knowledge  and
belief,  the  undersigned  certifies  that  the  information  set  forth  in the
Statement is true, correct and complete.



                               SMITHKLINE BEECHAM BIOLOGICALS MANUFACTURING S.A.


                               By:/s/ Donald F. Parman
                                  ------------------------------
                                  Donald F. Parman
                                  Attorney-in-Fact



DATED:  June 9, 2000












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