TECHNOLOGY FUNDING MEDICAL PARTNERS I L P
10-K, 1999-03-31
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<PAGE>
                           UNITED STATES
                  SECURITIES AND EXCHANGE COMMISSION
                        Washington, D.C.  20549

                             FORM 10-K

[X]  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE 
                  SECURITIES EXCHANGE ACT OF 1934

            For The Fiscal Year Ended December 31, 1998

                               OR

[ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                SECURITIES EXCHANGE ACT OF 1934

            For the transition period from N/A to N/A
                                           ---    ---

                   Commission File No. 814-124

           TECHNOLOGY FUNDING MEDICAL PARTNERS I, L.P.
           -------------------------------------------
         (Exact name of Registrant as specified in its charter)

          DELAWARE                            94-3166762
- -------------------------------    ------------------------------
(State or other jurisdiction of    (I.R.S. Employer  
incorporation or organization)      Identification No.)

2000 Alameda de las Pulgas, Suite 250
San Mateo, California                                       94403
- ---------------------------------------                  --------
(Address of principal executive offices)               (Zip Code)

                          (650) 345-2200
         --------------------------------------------------
        (Registrant's telephone number, including area code)


Securities registered pursuant to Section 12(b) of the Act:  None
Securities registered pursuant to Section 12(g) of the Act:  
Limited Partnership Units

Indicate by check mark whether the Registrant (1) has filed all 
reports required to be filed by Section 13 or 15(d) of the 
Securities Exchange Act of 1934 during the preceding 12 months (or 
for such shorter period that the Registrant was required to file 
such reports), and (2) has been subject to such filing 
requirements for the past 90 days.                    Yes X No
                                                         ---  ---
Indicate by check mark if disclosure of delinquent filers pursuant 
to Item 405 of Regulation S-K is not contained herein, and will 
not be contained, to the best of registrants knowledge, in 
definitive proxy or information statements incorporated by 
reference in Part III of this Form 10-K or any amendment to this 
Form 10-K.                                                  [   ]
No active market for the units of limited partnership interests 
("Units") exists, and therefore the market value of such Units 
cannot be determined.
Documents incorporated by reference:  Portions of the Prospectus 
dated May 3, 1993, forming a part of Registration Statement No. 
33-54002, as modified by Cumulative Supplement No. 4 dated January 
4, 1995, filed pursuant to Rule 424(c) of the General Rules and 
Regulations under the Securities Act of 1933 are incorporated by 
reference in Parts I and III hereof.  Portions (pages 23-25) of 
the Prospectus of Technology Funding Venture Capital Fund VI, LLC, 
as revised June 4, 1998 (accession number 0000950133-98-002220), 
forming a part of the December 5, 1997 Pre-effective Amendment No. 
1 to the Form N-2 Registration Statement No. 333-23913 dated July 
11, 1997, and incorporated by reference in part III hereof.

<PAGE>

                                   PART I

Item 1.  BUSINESS
- ------   --------

Technology Funding Medical Partners I, L.P. (the 
"Partnership") is a limited partnership organized under 
the laws of the State of Delaware on September 3, 1992, 
and was inactive until it commenced the sale of Units in 
May 1993.  The purpose of the Partnership is to make 
venture capital investments in emerging growth companies 
as described in the "Introductory Statement" and 
"Business of the Partnership" sections of the Prospectus 
dated May 3, 1993.  The Partnership has elected to be a 
business development company under the Investment Company 
Act of 1940, as amended (the "Act"), and operates as a 
non-diversified investment company as that term is 
defined in the Act.  Additional characteristics of the 
Partnership's business are discussed in the "Risk 
Factors" and "Conflicts of Interest" sections of the 
Prospectus, which sections are also incorporated herein 
by reference.  The Partnership Agreement provides that 
the Partnership will terminate December 31, 2002, subject 
to the right of the Individual General Partners to extend 
the term for up to two additional two-year periods.

Item 2.  PROPERTIES
- ------   ----------

The Registrant has no material physical properties.

Item 3.  LEGAL PROCEEDINGS
- ------   -----------------

There are no material pending legal proceedings to which 
the Registrant is party or of which any of its property 
is the subject, other than routine litigation incidental 
to the business of the Partnership.

Item 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
- ------   ---------------------------------------------------

No matter was submitted to a vote of the holders of 
units of limited partnership interests ("Units") during 
1998.
PART II

Item 5.  MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED 
- ------   -------------------------------------------------
         STOCKHOLDER MATTERS
         -------------------

        (a) There is no established public trading market for the 
            Units.

        (b) At December 31, 1998, there were 832 record holders 
            of Units.

        (c) The Registrant, being a partnership, does not pay 
            dividends. Distributions of cash and securities, 
            however, may be made to the partners in the 
            Partnership pursuant to the Registrant's Partnership 
            Agreement.


Item 6.  SELECTED FINANCIAL DATA
- ------   -----------------------

<TABLE>
<CAPTION>
                                              For the Years Ended and As of December 31,
                                       -------------------------------------------------------
                                       1998          1997        1996         1995        1994
                                      ------        ------      ------       ------      ------

<S>                               <C>             <C>          <C>         <C>        <C>

Interest income                   $      693        73,349     178,979      245,800     132,394
Dividend income                       15,967           136          --           --          --
Net operating loss                  (599,338)     (480,820)   (410,597)    (328,499)   (188,769)
Net realized (loss) gain from
 sales of equity investments        (331,660)        1,168      (1,876)          --          --
Realized losses from investment
 write-downs                        (299,280)           --          --           --          --
Net realized loss                 (1,230,278)     (479,652)   (412,473)    (328,499)   (188,769)
Change in net unrealized 
 fair value of
 equity investments                   (7,477)    1,101,284     377,961       (8,447)         --
Net (loss) income                 (1,237,755)      621,632     (34,512)    (336,976)   (188,769)
Net realized loss
 per Unit                                (15)           (6)         (5)          (4)         (4)
Total assets                       5,672,957     6,646,391   6,019,828    6,057,701   4,876,769
Distributions declared                    --            --          --       77,789     132,394
Distributions declared
 per Unit (1)                             --            --          --            1           3

(1)  Calculation is based on distributions declared to Limited Partners divided by weighted 
average number of Units outstanding during the year.


Refer to the financial statement notes entitled "Summary of Significant Accounting Policies" and 
"Allocation of Profits and Losses" for a description of the method of calculation of net realized 
income (loss) per Unit.
</TABLE>

<PAGE>

Item 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL 
- ------   -------------------------------------------------
CONDITION AND RESULTS OF OPERATIONS
- -----------------------------------

Liquidity and Capital Resources
- -------------------------------

During 1998, net cash used by operating activities totaled 
$531,105.  The Partnership paid management fees of $161,597 
to the Managing General Partners and paid related parties 
$286,863 for operating expenses.  In addition, $31,987 was 
paid to the Individual General Partners as compensation for 
their services.  The Partnership paid other operating 
expenses of $63,877 and interest on borrowings of $3,441, and 
received $16,660 in interest and dividend income.
During 1998, the Partnership received proceeds from sales of 
equity investments of $171,919.  At December 31, 1998, the 
Partnership was not committed to fund any additional 
investments.
The Partnership has a borrowing account with a financial 
institution.  The borrowing capacity of this account which 
fluctuates based on collateral value was $285,137 at December 
31, 1998.  The outstanding balance was $202,436 at December 
31, 1998.  The Partnership's investments in Megabios Corp. 
and Axys Pharmaceuticals, Inc. are pledged as collateral.  
The borrowing capacity of this account was $0 and the 
outstanding balance was $241,800 at March 26, 1999.  The 
Partnership, if required to by the lender, intends to repay 
this borrowing from the proceeds of investment sales or 
support from the Managing General Partners.
Cash and cash equivalents at December 31, 1998, were $387.  
Future proceeds from investment sales and the borrowing 
capacity of the fund along with Managing General Partners' 
support are expected to be adequate to fund Partnership 
operations through the next twelve months.
Results of Operations
- ---------------------

1998 compared to 1997
- ---------------------

Net loss was $1,237,755 for 1998 compared to net income of 
$621,632 in 1997.  The increase in net loss was primarily due 
to a $1,108,761 decrease in the net unrealized fair value of 
equity investments, a $332,828 increase in losses from sales 
of equity investments, and $299,280 in realized losses from 
investment write-downs.

The Partnership recorded a decrease in equity investment fair 
value of $7,477 in 1998, compared to an increase of 
$1,101,284 in 1997.  The 1998 decrease was primarily 
attributable to decreases in portfolio companies in the 
pharmaceuticals and medical/diagnostic equipment industries, 
partially offset by increases in the biotechnology industry.  

Realized losses from sales of equity investments totaled 
$331,660 in 1998 and were primarily attributable to the sale 
of CV Therapeutics, Inc.

During 1998, the Partnership recorded realized losses from 
investment write-downs of $299,280 attributable to ConjuChem, 
Inc. (formerly RedCell, Inc.).

Total operating expenses were $419,414 and $355,904 for 1998 
and 1997, respectively.  As disclosed in Note 3 to the 
financial statements, the Partnership may not reimburse the 
General Partners for certain expenses that aggregate more 
than three percent of total Limited Partner capital 
contributions.  As a result, operating expenses of $62,535 
and $0 were initially absorbed by the General Partners in 
1998 and 1997, respectively.  During 1998, it was determined 
that certain operational costs, primarily rent and 
professional fees, paid directly by the Partnership were not 
subject to the general partner expense limitation.  
Consequently, $66,383 of direct partnership expenses absorbed 
by the General Partners in prior years were recognized as 
additional expenses in 1998.  Also discussed in Note 3, the 
Managing General Partners re-evaluated allocations to the 
Partnership in 1998 and determined that they had not fully 
recovered allocable operating expenses, primarily salary, 
benefits, and professional fees as permitted by the 
Partnership Agreement.  As a result, the Partnership was 
charged $66,810 of additional operating expenses in 1998, of 
which $10,802 and $56,008 related to 1997 and prior years, 
respectively.  If the additional expense had been recorded in 
prior years and had the operating expense limitation 
described in Note 3 not been in effect, total operating 
expenses would have been $348,756 and $366,706 for 1998 and 
1997, respectively.

Given the inherent risk associated with the business of the 
Partnership, the future performance of the portfolio company 
investments may significantly impact future operations.

1997 compared to 1996
- ---------------------

Net income was $621,632 for 1997 compared to net loss of 
$34,512 in 1996.  The increase to net income was primarily 
due to a $723,323 increase in the change in net unrealized 
fair value of equity investments.  This change was partially 
offset by a $105,630 decrease in interest income.

The Partnership recorded an increase in equity investment 
unrealized fair value of $1,101,284 in 1997, compared to an 
increase of $377,961 in 1996.  The 1997 increase was 
primarily attributable to increases in portfolio companies in 
the pharmaceuticals and biotechnology industries. 

The Partnership recorded interest income of $73,349 and 
$178,979 for the years ended December 31, 1997 and 1996, 
respectively.  The decrease was mainly due to lower cash and 
cash equivalents balances in 1997 resulting from new and 
follow-on investments.

Total operating expenses were $355,904 and $391,841 for 1997 
and 1996, respectively.  Included in 1997 operating expenses 
are the costs of the Partnership's relocation of its 
administrative and investor service operations to Santa Fe, 
New Mexico.  As disclosed in Note 3 to the financial 
statements, a determination was made in 1996 that certain 
operational costs paid directly by the Partnership, which had 
been absorbed by the General Partners in prior years were not 
subject to the 3% operational expense reimbursement 
limitation.  Accordingly, $128,120 was reimbursed by the 
Partnership to the General Partners.

YEAR 2000
- ---------

Widespread use of computer programs that use two digits 
rather than four to store, calculate, and display year values 
in dates may cause computer systems to malfunction in the 
year 2000, resulting in significant business delays and 
disruptions.

The Partnership's State of Readiness
- ------------------------------------

Computer services are provided to the Partnership by its 
Managing General Partner, Technology Funding Inc. ("TFI".) 
For several years, TFI has sought to use Year 2000 compliant 
storage formats and algorithms in its internally-developed 
and maintained systems.  TFI has also completed initial 
evaluations of computer systems, software, and embedded 
technologies.  Those evaluations confirmed that certain 
components of its network server hardware and operating 
systems, voice mail system, e-mail system, and accounting 
software may have Year 2000 compliance issues.  These 
resources and several less-critical components of the systems 
environment were all scheduled as part of normal maintenance 
and replacement cycles to be replaced or upgraded as Year 
2000 compatible components became available from vendors 
during 1998 and 1999.  That program remains on schedule to 
provide Year 2000 capable systems timely without significant 
expenditures or disruption of Partnership operations.  
However, the risk remains that TFI may not be able to verify 
whether Year 2000 compatibility claims by vendors are 
accurate, or whether changes undertaken to achieve Year 2000 
compatibility will create other undetected problems in 
associated systems.  Therefore, TFI anticipates that Year 
2000 compliance testing and maintenance of these systems will 
continue as needed into the first quarter of 2000.  

As part of Year 2000 evaluation, TFI has also assembled a 
database listing its significant suppliers to assess the 
extent to which it needs to prepare for any of those parties' 
potential failure to remediate their Year 2000 compliance 
issues.  TFI is reviewing public Year 2000 statements of 
those suppliers and preparing questionnaires to be sent to 
mission-critical vendors whose public statements were not 
adequate for assessment.  TFI will continue to monitor its 
significant suppliers as part of its Year 2000 evaluation.  
However, there can be no guarantee that the systems of other 
companies on which TFI relies will be timely converted, or 
that failure to convert will not have a material adverse 
effect on the Partnership and its operations.  TFI is also 
working with the Partnership's portfolio companies to 
determine the extent to which their operations are vulnerable 
to Year 2000 issues.  There can be no guarantee that the 
systems of portfolio companies in which the Partnership has 
invested will be timely converted, or that failure to convert 
will not have a material adverse effect on the Partnership.  

The Cost to Address Year 2000 Issues
- ------------------------------------

Expenditures in 1998 related to Year 2000 issues were not 
material to the Partnership's financial statements.  TFI 
expects that additional expenditures for Year 2000 compliance 
will not be material to the Partnership.  

The Risks Associated with Year 2000 Issues
- ------------------------------------------

Any failure by the portfolio companies in which the 
Partnership has invested, or by those portfolio companies' 
key suppliers or customers, to anticipate and avoid Year 2000 
related problems at reasonable cost could have a material 
adverse effect on the value of and/or the timing of 
realization of value from the Partnership's investments.  If 
Year 2000 compliance issues are not resolved by December 31, 
1999, internal system failures or miscalculations could cause 
a temporary inability to process transactions, loss of 
ability to send or receive e-mail and voice mail messages, or 
disruptions in other normal business activities.  
Additionally, failure of third parties on whom TFI relies to 
remediate their Year 2000 issues timely could result in 
disruptions in the Partnership's relationship with its 
financial institutions, temporary disruptions in processing 
transactions, unanticipated costs, and problems related to 
the Partnership's daily operations.  While TFI continues to 
address its internal Year 2000 issues, until TFI receives and 
evaluates responses from a significant number of its 
suppliers, the overall risks associated with the Year 2000 
issue remain difficult to describe and quantify.  There can 
be no guarantee that the Year 2000 issue will not have a 
material adverse effect on the Partnership and its 
operations.

TFI's Contingency Plan
- ----------------------

As part of its normal efforts to assure business continuation 
in the event of natural disasters, systems failures, or other 
disruptions, TFI has prepared contingency plans including an 
extensive Year 2000 contingency plan.  Taken together with 
TFI's Year 2000 remediation plan, it identifies potential 
points of failure, approaches to correcting known Year 2000 
problems, dates by which the preferred corrections are 
anticipated to be made and tested, and alternative approaches 
if the corrections are not completed timely or are later 
found to be inadequate.  Although backup systems and 
contingency approaches have been identified for most mission-
critical systems and vendor dependencies, there remain some 
systems for which no good alternative exists, and there may 
be some problems that prove more intractable than currently 
anticipated.  


Item 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
- ------   -------------------------------------------

The financial statements of the Registrant are set forth in 
Item 14.

Item 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON 
- ------   ------------------------------------------------
ACCOUNTING AND FINANCIAL DISCLOSURE
         -----------------------------------

None

PART III

Item 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT
- -------  --------------------------------------------------

As a partnership, the Registrant has no directors or 
executive officers.  The Management Committee is responsible 
for the management and administration of the Partnership.  
The members of the Management Committee consist of three 
Individual General Partners and a representative from each of 
Technology Funding Ltd., a California limited partnership 
("TFL"), and its wholly owned subsidiary, Technology Funding 
Inc., a California corporation ("TFI").  TFL and TFI are the 
Managing General Partners.  Information concerning the 
ownership of TFL and the business experience of the key 
officers of TFI and the partners of TFL is incorporated by 
reference from the sections entitled "Management of the 
Partnership - The Managing General Partners" and "Management 
of the Partnership - Key Personnel of the Managing General 
Partners" in the Prospectus as modified by Cumulative 
Supplement No. 4 dated January 4, 1996, which are 
incorporated herein by reference.  Changes in this 
information that have occurred since the date of the 
Prospectus are included on pages 23-25 in the Technology 
Funding Venture Capital Fund VI, LLC Prospectus as revised 
June 4, 1998 (accession number 000950133-98-002220), forming 
a part of the December 5, 1997 Pre-effective Amendment No 1 
to the Form N-2 Registration Statement No 333-23913 dated 
July 11, 1997, which are incorporated herein by reference.

Item 11. EXECUTIVE COMPENSATION
- -------  ----------------------

As a partnership, the Registrant has no officers or 
directors.  In 1998, the Partnership incurred $158,597 in 
management fees.  The fees are designed to compensate the 
Managing General Partners for General Partner Overhead 
incurred in performing management duties for the Partnership 
through December 31, 1998.  General Partner Overhead (as 
defined in the Partnership Agreement) includes the General 
Partners' share of rent and utilities, and certain salaries 
and benefits paid by the Managing General Partners in 
performing their obligations to the Partnership.  As 
compensation for their services, the Individual General 
Partners each receive $6,000 annually beginning on the 
Commencement Date, plus $1,000 for each attended meeting of 
the Individual General Partners, and related expenses.  For 
the year ended December 31, 1998, $31,987 of such fees were 
paid.

Item 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND
- -------  ---------------------------------------------------
MANAGEMENT
- ----------

Not applicable.  No Limited Partner beneficially holds more 
than 5% of the aggregate number of Units held by all Limited 
Partners, and neither the General Partners nor any of their 
officers, directors or partners own any Units.  The three 
Individual General Partners each own 20 Units; in March 1999, 
one of the General Partners withdrew from his position and 
his Units were transferred to his successor.  The Individual 
General Partners control the affairs of the Partnership 
pursuant to the Partnership Agreement.

Item 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
- -------  ----------------------------------------------

The Registrant, or its investee companies, have engaged in no 
transactions with the General Partners or their officers and 
partners other than as described above, in the notes to the 
financial statements, or in the Partnership Agreement.

PART IV

Item 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON 
- -------  -------------------------------------------------------
         FORM 8-K
         --------

         (a)  List of Documents filed as part of this Annual Report on 
Form 10-K

             (1)  Financial Statements - the following financial 
statements are filed as a part of this Report:

                  Independent Auditors' Report
                  Balance Sheets as of December 31, 1998
                    and 1997
                  Statements of Operations for the years
                    ended December 31, 1998, 1997 and 1996
                  Statements of Partners' Capital for the years
                    ended December 31, 1998, 1997 and 1996
                  Statements of Cash Flows for the years
                    ended December 31, 1998, 1997 and 1996
                  Notes to Financial Statements

             (2)  Financial Statement Schedules

All schedules have been omitted because they are 
not applicable or the required information is 
included in the financial statements or the notes 
thereto.

             (3)  Exhibits

Registrant's Amended and Restated Limited 
Partnership Agreement (incorporated by reference to 
Exhibit A to Registrant's Prospectus dated May 3, 
1993, included in Registration Statement No. 33-
54002 filed pursuant to Rule 424(b) of the General 
Rules and Regulations under the Securities Act of 
1933).

         (b)  Reports on Form 8-K

              No reports on Form 8-K were filed by the Registrant 
during the year ended December 31, 1998.

         (c)  Financial Data Schedule for the year ended and as of 
December 31, 1998 (Exhibit 27).



                   INDEPENDENT AUDITORS' REPORT
                   ----------------------------

The Partners
Technology Funding Medical Partners I, L.P.:


We have audited the accompanying balance sheets of Technology 
Funding Medical Partners I, L.P. (a Delaware limited partnership) as 
of December 31, 1998 and 1997, and the related statements of 
operations, partners' capital, and cash flows for each of the years 
in the three-year period ended December 31, 1998.  These financial 
statements are the responsibility of the Partnership's management.  
Our responsibility is to express an opinion on these financial 
statements based on our audits.

We conducted our audits in accordance with generally accepted 
auditing standards.  Those standards require that we plan and 
perform the audit to obtain reasonable assurance about whether the 
financial statements are free of material misstatement.  An audit 
includes examining, on a test basis, evidence supporting the amounts 
and disclosures in the financial statements.  Our procedures 
included confirmation of certain securities owned, by correspondence 
with the individual investee companies, and a physical examination 
of those securities held by a safeguarding agent as of December 31, 
1998 and 1997.  An audit also includes assessing the accounting 
principles used and significant estimates made by management, as 
well as evaluating the overall financial statement presentation.  We 
believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present 
fairly, in all material respects, the financial position of 
Technology Funding Medical Partners I, L.P. as of December 31, 1998 
and 1997, and the results of its operations and its cash flows for 
each of the years in the three-year period ended December 31, 1998, 
in conformity with generally accepted accounting principles.



Albuquerque, New Mexico                                  /S/KPMG LLP
March 26, 1999




<PAGE>
BALANCE SHEETS
- --------------
<TABLE>
<CAPTION>
                                                  December 31,
                                              -------------------
                                                1998       1997
                                               ------     ------
<S>                                         <C>         <C>      
ASSETS

Equity investments (cost basis of
 $4,208,359 and $5,011,218 in 1998
 and 1997, respectively)                    $5,671,650  6,481,986

Cash and cash equivalents                          387    157,137

Organizational costs (net of accumulated
 amortization of $40,000 and $34,000 
 in 1998 and 1997, respectively)                    --      6,000

Other assets                                       920      1,268
                                             ---------  ---------
     Total assets                           $5,672,957  6,646,391
                                             =========  =========

LIABILITIES AND PARTNERS' CAPITAL

Accounts payable and accrued expenses       $   38,899     29,213

Due to related parties                          84,157     31,958

Short-term borrowings                          202,436         --
                                             ---------  ---------
     Total liabilities                         325,492     61,171

Commitments and subsequent events
 (Notes 3, 5, 8, and 9)

Partners' capital:
  Limited Partners 
   (Units outstanding of 79,716 
    for both 1998 and 1997)                  3,909,982  5,127,957
  General Partners                             (25,808)   (13,505)
  Net unrealized fair value increase 
   from cost of equity investments           1,463,291  1,470,768
                                             ---------  ---------

     Total partners' capital                 5,347,465  6,585,220
                                             ---------  ---------

     Total liabilities and partners'
       capital                              $5,672,957  6,646,391
                                             =========  =========
</TABLE>
See accompanying notes to financial statements.

<PAGE>
STATEMENTS OF OPERATIONS
- ------------------------
<TABLE>
<CAPTION>
                                 For the Years Ended December 31,
                               ------------------------------------
                                 1998          1997          1996
                                ------        ------        ------
<S>                          <C>            <C>          <C>      
Income:
  Interest income           $       693        73,349      178,979
  Dividend income                15,967           136           --
                              ---------     ---------      -------
     Total income                16,660        73,485      178,979

Costs and expenses:
  Management fees               158,597       158,597      158,597
  Individual General 
   Partners' compensation        31,987        31,804       31,138
  Amortization of
   organizational costs           6,000         8,000        8,000
  Operating expenses:
    Administrative and 
     investor services          252,111       210,039      154,880
    Investment operations        56,057        69,447       62,721
    Computer services            59,282        45,699       38,897
    Professional fees            44,675        30,719       61,233
    Expenses absorbed by
     General Partners           (62,535)           --      (54,010)
    Expenses absorbed by
     General Partners in
     prior years                 66,383            --      128,120
    Interest expense              3,441            --           --
                              ---------     ---------      -------
     Total operating expenses   419,414       355,904      391,841
                               --------     ---------      -------
     Total costs and expenses   615,998       554,305      589,576
                               --------     ---------      -------
Net operating loss             (599,338)     (480,820)    (410,597)

Net realized (loss) gain from
  sales of equity investments  (331,660)        1,168       (1,876)
Realized losses from 
  investment write-downs       (299,280)           --           --
                               --------     ---------      -------
Net realized loss            (1,230,278)     (479,652)    (412,473)

Change in net unrealized fair
 value of equity investments     (7,477)    1,101,284      377,961
                               --------     ---------      -------
Net (loss) income           $(1,237,755)      621,632      (34,512)
                               ========     =========      =======
Net realized loss per Unit  $       (15)           (6)          (5)
                               ========     =========      =======
</TABLE>
See accompanying notes to financial statements.

<PAGE>
STATEMENTS OF PARTNERS' CAPITAL
- -------------------------------
<TABLE>
<CAPTION>
For the years ended December 31, 1998, 1997 and 1996:
                                                             Net Unrealized Fair Value
                                    Limited      General     (Decrease) Increase from
                                    Partners     Partners    Cost of Equity Investments     Total
                                   ----------   ----------  ----------------------------   -------
<S>                               <C>            <C>              <C>                    <C>       
Partners' capital,
 December 31, 1995                $6,011,161     (4,584)              (8,477)             5,998,100

Change in net unrealized fair
 value of equity investments              --         --              377,961                377,961
Net realized loss                   (408,348)    (4,125)                  --               (412,473)
                                   ---------     ------            ---------              ---------
Partners' capital,
 December 31, 1996                 5,602,813     (8,709)             369,484              5,963,588

Change in net unrealized fair
 value of equity investments              --         --            1,101,284              1,101,284
Net realized loss                   (474,856)    (4,796)                  --               (479,652)
                                   ---------     ------            ---------              ---------
Partners' capital,
 December 31, 1997
                                   5,127,957    (13,505)           1,470,768              6,585,220
Change in net unrealized fair
 value of equity investments              --         --               (7,477)                (7,477)
Net realized loss                 (1,217,975)   (12,303)                  --             (1,230,278)
                                   ---------     ------            ---------              ---------
Partners' capital,
 December 31, 1998
                                  $3,909,982    (25,808)           1,463,291              5,347,465
                                   =========     ======            =========              =========

</TABLE>
See accompanying notes to financial statements.

<PAGE>
STATEMENTS OF CASH FLOWS
- ------------------------
<TABLE>
<CAPTION>
                                      For the Years Ended December 31,
                                   -----------------------------------
                                    1998           1997          1996
                                   ------         ------        ------
<S>                            <C>             <C>          <C>     
Cash flows from operating
 activities:
  Interest received              $    693        62,579       160,695
  Dividends received               15,967           136            --
  Cash paid to vendors            (63,877)     (100,938)     (111,299)
  Interest paid on
   short-term borrowings           (3,441)           --            --
  Cash paid to related
   parties                       (480,447)     (440,388)     (480,081)
                                  -------     ---------     ---------
    Net cash used by
     operating activities        (531,105)     (478,611)     (430,685)
                                  -------     ---------     ---------
Cash flows from investing
  activities:
  Purchases of equity
   investments                         --    (1,357,786)   (1,533,007)
  Proceeds from sales of
   equity investments             171,919         8,481            --
                                  -------     ---------     ---------
    Net cash provided (used)
     by investing activities      171,919    (1,349,305)   (1,533,007)
                                  -------     ---------     ---------
Cash flows from financing
 activities:
  Proceeds from short-term
   borrowings, net                202,436            --            --
                                  -------     ---------     ---------
    Net cash provided by
     financing activities         202,436            --            --
                                  -------     ---------     ---------
Net decrease in cash and
 cash equivalents                (156,750)   (1,827,916)   (1,963,692)

Cash and cash equivalents 
 at beginning of year             157,137     1,985,053     3,948,745
                                  -------     ---------     ---------
Cash and cash equivalents 
 at end of year                  $    387       157,137     1,985,053
                                  =======     =========     =========

Reconciliation of net (loss)
 income to net cash used by
 operating activities:

Net (loss) income             $(1,237,755)      621,632       (34,512)

Adjustments to reconcile net
 (loss) income to net cash
 used by operating activities:
   Amortization of
    organizational costs            6,000         8,000         8,000
   Change in net unrealized
    fair value of equity
    investments                     7,477    (1,101,284)     (377,961)
   Net realized loss (gain)
    from sales of equity
    investments                   331,660        (1,168)        1,876
   Realized losses from
    investment write-downs        299,280            --            --
Changes in:
   Accounts payable and
    accrued expenses                9,686         1,665         1,433
   Due to related parties          52,199         3,266       (10,794)
   Other, net                         348       (10,722)      (18,727)
                                ---------     ---------       -------
Net cash used by operating
 activities                   $  (531,105)     (478,611)     (430,685)
                                =========     =========       =======

</TABLE>
See accompanying notes to financial statements.

<PAGE>
NOTES TO FINANCIAL STATEMENTS
- -----------------------------

1.  Summary of Significant Accounting Policies
    ------------------------------------------

Organization
- ------------

Technology Funding Medical Partners I, L.P. (the "Partnership") is a 
limited partnership organized under the laws of the State of Delaware 
on September 3, 1992.  The purpose of the Partnership is to make 
venture capital investments in emerging growth companies.  The 
Partnership elected to be a business development company under the 
Investment Company Act of 1940, as amended (the "Act"), and operates 
as a non-diversified investment company as that term is defined in the 
Act.  The Managing General Partners are Technology Funding Ltd. 
("TFL"), and Technology Funding Inc. ("TFI"), a wholly owned 
subsidiary of TFL.  There are also three Individual General Partners; 
in March 1999, one Individual General Partner withdrew from his 
position and a successor was designated.  A wholly owned subsidiary of 
TFI, Technology Funding Securities Corporation ("TFSC"), was the 
dealer-manager for the offering.

For the period from September 3, 1992, through May 3, 1993, the 
Partnership was inactive.  The Partnership's registration statement 
was declared effective by the Securities and Exchange Commission on 
May 3, 1993, and the Partnership began selling units of limited 
partnership interests ("Units") in May of 1993.

On October 8, 1993, the Commencement Date, the minimum number of Units 
required to begin Partnership operations (12,000) had been sold.  The 
offering terminated with 79,716 Units sold on May 3, 1995.  The 
Partnership Agreement provides that the Partnership will continue 
until December 31, 2002, unless further extended for up to two 
additional two-year periods from such date if the Individual General 
Partners so determine or unless sooner dissolved.

Preparation of Financial Statements and Use of Estimates
- --------------------------------------------------------

The preparation of financial statements in conformity with generally 
accepted accounting principles requires management to make estimates 
and assumptions that affect the amounts reported in the financial 
statements and accompanying notes. Actual results could differ from 
those estimates.  Estimates are used when accounting for investments, 
change in unrealized fair value of investments, liabilities and 
contingencies.  Because of the inherent uncertainty of valuation, the 
estimated fair value of investments may differ significantly from the 
values that would have been used had a ready market for investments 
existed, and the differences could be material.  

Equity Investments
- ------------------

The Partnership's method of accounting for investments, in accordance 
with generally accepted accounting principles, is the fair value basis 
used for investment companies.  The fair value of Partnership equity 
investments is their initial cost basis with changes as noted below:

The fair value for publicly traded equity investments (marketable 
equity securities) is based upon the five-day-average closing sales 
price or bid/ask price that is available on a national securities 
exchange or over-the-counter market.  Certain publicly traded equity 
investments may not be marketable due to selling restrictions and for 
those securities, an illiquidity discount of up to 33% is applied when 
determining the fair value; the actual discount percentage is based on 
the type and length of the restrictions.  Investments valued under 
this method were $868,154 and $1,180,687 at December 31, 1998 and 
1997, respectively.

All investments which are not publicly traded are valued at fair 
market value as determined by the Managing General Partners in the 
absence of readily ascertainable market values. Investments valued 
under this method were $4,803,496 and $5,301,299 at December 31, 1998 
and 1997, respectively.  Generally, investments in privately held 
companies are valued at original cost unless there is clear evidence 
of a change in fair value, such as a recent round of third-party 
financings or events that, in the opinion of the Managing General 
Partners, indicate a change in value. 

Convertible and subordinated notes receivable are stated at cost plus 
accrued interest, which is equivalent to fair value, and are included 
in equity investments as repayment of these notes generally occurs 
through conversion into equity investments.

Venture capital limited partnership investments are initially recorded 
at cost and are valued based on the fair value of the underlying 
investments.  Limited partnership distributions that are a return of 
capital reduce the cost basis of the Partnership's investment.  
Distributions from limited partnership cumulative earnings are 
reflected as realized gains by the Partnership.

Where, in the opinion of the Managing General Partners, events 
indicate that the fair value of equity and venture capital investments 
and convertible and subordinated notes receivable may not be 
recoverable, a write-down to estimated fair value is recorded.  
Temporary changes in fair value result in increases or decreases to 
the unrealized fair value of equity investments. Adjustments to fair 
value basis are reflected as "Change in net unrealized fair value of 
equity investments."  In the case of an other than temporary decline 
in value below cost basis, an appropriate reduction in the cost basis 
is recognized as a realized loss with the fair value being adjusted to 
match the new cost basis. Cost basis adjustments are reflected as 
"Realized losses from investment write-downs" or "Net realized loss 
from venture capital limited partnership investments" on the 
Statements of Operations. 

Sales of equity investments are recorded on the trade date.  The basis 
on which cost is determined in computing realized gains or losses is 
specific identification.

Cash and Cash Equivalents
- -------------------------

Cash and cash equivalents are principally comprised of cash invested 
in demand accounts and money market instruments and are stated at cost 
plus accrued interest.  The Partnership considers all money market and 
short-term investments with an original maturity of three months or 
less to be cash equivalents.

Organizational Costs
- --------------------

Organizational costs of $40,000 are amortized over 60 months using the 
straight-line method.

Net Realized Income (Loss) Per Unit
- -----------------------------------

Net realized income (loss) per Limited Partner Unit is calculated by 
dividing the weighted average number of Limited Partner Units 
outstanding of 79,716 for the years ended December 31, 1998, 1997 and 
1996, into total net realized loss allocated to the Limited Partners.  
The Managing General Partners contributed 0.1% of total Limited 
Partner capital contribution and did not receive any Partnership 
units.

Provision for Income Taxes
- --------------------------

No provision for income taxes has been made by the Partnership as the 
Partnership is not directly subject to taxation.  The partners are to 
report their respective shares of Partnership income or loss on their 
individual tax returns.

The accompanying financial statements are prepared using generally 
accepted accounting principles which may not equate to tax accounting.  
The difference in the total book and tax cost basis as of December 31, 
1998, is not material.

Syndication Fees
- ----------------

Syndication fees, which consist of commissions and certain 
organizational and offering costs, are deducted from the partners' 
capital accounts.  Pursuant to the Partnership Agreement, selling 
commissions are allocated solely to the Limited Partners.  All other 
syndication fees are allocated 99% to the Limited Partners and 1% to 
the Managing General Partners.  Syndication fees are not deductible 
for income tax purposes.  Such fees may result in a reduction of any 
gain (or an increase in any loss) realized for tax purposes by the 
partners upon dissolution of the Partnership or a transfer of their 
interests.

2.  Financing of Partnership Operations
    -----------------------------------

The Managing General Partners expect cash received from the future 
liquidation of Partnership investments and short-term borrowings will 
provide the necessary liquidity to fund Partnership operations.  The 
Partnership may be dependent upon the financial support of the 
Managing General Partners to fund operations if future proceeds are 
not received timely.  The Managing General Partners have committed to 
support the Partnership's working capital requirements through short-
term advances as necessary.

3.  Related Party Transactions
    --------------------------

Included in costs and expenses are related party costs as follows:
<TABLE>
<CAPTION>
                                       1998       1997        1996
                                      ------     ------      ------
  <S>                                <C>         <C>        <C>

  Management fees                    $158,597    158,597    158,597
  Individual General Partners'
   compensation                        31,987     31,804     31,138
  Amortization of organizational
   costs                                6,000      8,000      8,000
  Reimbursable operating expenses:
    Administrative and investor 
     services                         229,092    145,407    114,191
    Investment operations              49,840     63,311     52,354
    Computer services                  59,282     44,535     38,897
    Expenses absorbed by
     General Partners                 (62,535)        --    (54,010)
    Expenses absorbed by General
     Partners in prior years           66,383         --    128,120
</TABLE>

Management fees are equal to 2% of the total Limited Partner capital 
contributions for the first year of Partnership operations through the 
sixth year.  Beginning in the seventh year, management fees will 
decline by 10% per year from the initial 2%.  Management fees 
compensate the Managing General Partners solely for General Partner 
Overhead (as defined in the Partnership Agreement) incurred in 
supervising the operation and management of the Partnership and the 
Partnership's investments.  Pursuant to the Partnership Agreement, a 
full first-year fee is paid to the Managing General Partners as each 
additional Limited Partner is admitted to the Partnership, regardless 
of the date the Limited Partner is admitted.  Management fees payable 
were $23,433 and $26,433 at December 31, 1998 and 1997, respectively.

Pursuant to the Partnership Agreement, the Partnership shall reimburse 
the Managing General Partners for operational costs incurred by the 
Managing General Partners in conjunction with the business of the 
Partnership.  The Partnership may not reimburse the Managing General 
Partners for certain operational costs that aggregate more than 3% of 
total Limited Partner capital contributions of the Partnership in each 
year through the first five years of operations after the termination 
of Unit sales, and 1.5% in any year thereafter.  For purposes of this 
limitation, the Partnership's operating year begins on May 3.  Amounts 
due to related parties were $60,724 and $5,525 at December 31, 1998 
and 1997, respectively.

In 1998 and 1996, the Managing General Partners absorbed $62,535 and 
$54,010, respectively, in operating expenses.  In late 1998, it was 
determined that certain overhead costs, primarily rent, absorbed by 
the General Partners in prior years, were not subject to this 
limitation; consequently, $66,383 was reimbursed to the General 
Partners.  No expenses were absorbed by the General Partners in 1997.  
In 1996, it was determined that certain operational costs paid 
directly to the Partnership, which had been absorbed by the General 
Partners in prior years were not subject to this limitation; 
consequently $128,120 was reimbursed to the General Partners.

The Managing General Partners allocate operating expenses incurred in 
connection with the business of the Partnership based on employee 
hours incurred.  In 1998, operating cost allocations to the 
Partnership were re-evaluated.  The Managing General Partners 
determined that they had not fully recovered allocable operating 
expenses, primarily salary, benefits, and professional fees, as 
permitted by the Partnership Agreement.  As a result, the Partnership 
was charged additional operating expenses of $66,810 consisting of 
$10,802, $16,842,and $39,166 for 1997, 1996 and prior years, 
respectively.  Had the additional expenses been recorded in prior 
years and had the operating expense limitation not been in effect, 
operating expenses would have been $348,756, $366,706 and $334,573 for 
1998, 1997, and 1996, respectively.

As compensation for their services, the Individual General Partners 
each receive $6,000 annually beginning on the Commencement Date, plus 
$1,000 for each of the management committee meetings attended and 
related expenses.  The three Individual General Partners each own 20 
Units; in March 1999, one of the Individual General Partners withdrew 
form his position and his units were transferred to his successor.

Effective November 1, 1997, TFL assigned its California office lease 
to Technology Funding Property Management LLC (TFPM), an entity that 
is affiliated to the Managing General Partner.  Under the terms of a 
rent agreement, TFPM charges the Partnership for its share of office 
rent and related overhead costs.  These amounts are included in 
administrative and investor service costs.

Under the terms of a computer service agreement, Technology 
Administrative Management, a division of TFL, charges the Partnership 
for its share of computer support costs.  These amounts are included 
in computer services expenses.

Officers of the Managing General Partners occasionally receive stock 
options as compensation for serving on the Boards of Directors of 
portfolio companies.  It is the Managing General Partners' policy that 
all such compensation be transferred to the investing partnerships.  
If the options are non-transferable, they are not recorded as an asset 
of the Partnership.  Any profit from the exercise of such options will 
be transferred if and when the options are exercised and the 
underlying stock is sold by the officers.

4.  Allocation of Profits and Losses
    --------------------------------

Net realized profit and loss of the Partnership are allocated based on 
the beginning-of-year partners' capital balances as follows:

(a)   Profits:

 (i) first, to those partners with deficit capital account 
balances in proportion to such deficits until the 
deficits have been eliminated; then

(ii) second, to the partners as necessary to offset net loss 
and sales commissions previously allocated to such 
partners; then

(iii)third, 75% to the Limited Partners as a group in 
proportion to the number of Units, 5% to the Limited 
Partners in proportion to the Unit months of each Limited 
Partner, and 20% to the Managing General Partners.  Unit 
months are the number of half months a Unit would be 
outstanding if held from the date the original holder of 
such Unit was deemed admitted into the Partnership until 
the termination of the offering of Units.

(b)   Losses:

(i)  first, to the partners as necessary to offset net profit 
previously allocated to the partners under (a)(iii) above 
plus losses from unaffiliated venture capital limited 
partnership investments; then

(ii) 99% to the Limited Partners as a group and 1% to the 
Managing General Partners.

Losses allocable to Limited Partners in excess of their capital 
account balances will be allocated to the Managing General Partners.  
Net profit thereafter, otherwise allocable to those Limited Partners, 
would be allocated to the Managing General Partners to the extent of 
such losses.  

As indicated above, losses from unaffiliated venture capital limited 
partnership investments are allocated pursuant to section (b).  Gains 
are allocated first to offset previously allocated losses pursuant to 
(b)(i) above, and then 99% to Limited Partners and 1% to the Managing 
General Partners.

Income earned from short-term investments during the Offering Period 
was allocated monthly, 99% to the Limited Partners and 1% to the 
Managing General Partners.

In no event shall the General Partners' interest in profits and losses 
be less than 1%.



5.  Equity Investments
    ------------------

At December 31, 1998, and December 31, 1997, equity investments consisted of:

<TABLE>
<CAPTION>
                                                       December 31, 1998     December 31, 1997
                                        Principal     ------------------     -----------------
                             Investment Amount or     Cost       Fair        Cost        Fair
Industry/Company    Position    Date      Shares      Basis      Value       Basis       Value
- ----------------    --------    ----      ------      -----      -----       -----       -----
<S>                <C>         <C>      <C>        <C>         <C>         <C>         <C>

Medical/Biotechnology
- ---------------------
Acusphere, Inc.    Series B
                   Preferred
                   shares      05/95     125,000   $  200,000    412,500     200,000     375,000
Acusphere, Inc.    Series C
                   Preferred
                   shares      05/96     163,552      350,001    539,722     350,001     490,656
Acusphere, Inc.    Series D
                   Preferred
                   shares      11/97      52,083      156,250    171,874     156,250     156,250
Biex, Inc.         Series E
                   Preferred
                   shares       8/97     120,000      300,000    300,000     300,000     300,000
ConjuChem, Inc.    Series B
(formerly          Preferred
 RedCell, Inc.)    shares      12/94     132,979            0          0     125,000           0
ConjuChem, Inc.    Convertible
(formerly          note
 RedCell, Inc.)                02/96     $89,966            0          0      98,149      98,149
ConjuChem, Inc.    Series C
(formerly          Preferred
 RedCell, Inc.)    share 
                   Warrant at
                   exercise              $13,495
                   price TBD;            aggregate
                   expiring              purchase
                   02/01       02/96     price              0          0           0           0
ConjuChem, Inc.    Convertible
(formerly          note
 RedCell, Inc.)                07/96     $71,973            0          0      76,131      76,131
ConjuChem, Inc.    Series C
(formerly          Preferred
 RedCell, Inc.)    share 
                   warrant at
                   exercise              $10,796
                   price TBD;            aggregate
                   expiring              purchase
                   07/01       07/96     price              0          0           0           0
CV Therapeutics,   Common
 Inc.              share
                   warrant at
                   $20.00;
                   expiring
                   09/00       09/95       1,920          768          0         768           0
CV Therapeutics,   Common
 Inc.              shares      11/96      26,455           --         --     487,224     240,211
Prolinx, Inc.      Series A
                   Preferred
                   shares      05/95     119,631      119,631    259,599     119,631     209,354
Prolinx, Inc.      Series A
                   Preferred
                   shares      12/95     124,369      124,369    269,881     124,369     217,646
Prolinx, Inc.      Series A
                   Preferred
                   shares      09/96     156,000      156,000    338,520     156,000     273,000
Prolinx, Inc.      Series B
                   Preferred
                   shares      07/97     164,835      288,461    417,308     288,461     288,461

Medical/Diagnostic Equipment
- ----------------------------
Endocare, Inc.     Common
                   shares      08/96       2,000        6,000      3,976       6,000       7,160

Endocare, Inc.     Common 
                   share
                   warrant at
                   $3.00;
                   expiring
                   08/01       08/96      30,000            0          0           0      13,050
Endocare, Inc.     Common 
                   shares      01/97      66,400      166,000    132,003     166,000     214,480
Endocare, Inc.     Common 
                   shares      01/97      84,000      294,000    166,992     294,000     300,720
LifeCell           Series B
 Corporation       Preferred
                   shares      11/96       2,500      232,089    349,860     232,089     232,089
LifeCell           Common 
 Corporation       share
                   warrant at
                   $4.13;
                   expiring
                   11/01       11/96      56,451        2,500     11,742       2,500      37,258
LifeCell           Series B
 Corporation       Preferred
                   shares      02/97          29        2,692      4,058       2,692       2,692
LifeCell           Series B
 Corporation       Preferred
                   shares      05/97          60        5,570      8,397       5,570       5,570
LifeCell           Series B
 Corporation       Preferred
                   shares      08/97          38        3,528      5,318       3,528       3,528
LifeCell           Series B
 Corporation       Preferred
                   shares      11/97          39        3,621      5,458       3,621       3,621
R2 Technology,     Series A-1
 Inc.              Preferred
                   shares      05/94     100,000      100,000    184,000     100,000     184,000
R2 Technology,     Series B
 Inc.              Preferred
                   share warrant
                   at $2.00;
                   expiring
                   11/00       11/95       2,417            0          0           0           0

R2 Technology,     Series B-1
 Inc.              Preferred
                   shares      03/96      17,134       34,268     34,268      34,268      34,268

Health Information Systems
- --------------------------
ADESSO Specialty   Series D
 Services          Preferred
 Organization      shares
 Inc.                          12/97      11,905      100,002    100,002     100,002     100,002
CareCentric        Series A
 Solutions, Inc.   Preferred
                   shares      10/95      66,667      100,000     70,000     100,000      65,710
CareCentric        Series B
 Solutions, Inc.   Preferred
                   shares      09/96      86,999      130,499     91,349     130,499      85,749
CareCentric        Series C
 Solutions, Inc.   Preferred
                   shares      12/97      31,051       32,604     32,604      32,604      32,604
CareCentric        Common
 Solutions, Inc.   share
                   warrant at
                   $.15;
                   expiring
                   12/02       12/97      15,525       13,972     13,972      13,972      13,972

Pharmaceuticals
- ---------------
Axys               Common
 Pharmaceuticals,  shares
 Inc.                          12/95       9,464      125,000     53,831     125,000      78,930
Megabios Corp.     Common
                   shares      09/94      64,375      250,000    320,266     250,000     725,957
Megabios Corp.     Common
                   shares      12/94      19,312       75,001     96,077      75,001     217,781
Megabios Corp.     Common
                   shares      07/95      16,737       64,999     83,267      64,999     188,743
Neurex             Common
 Corporation       shares      09/96         149           --         --       3,129       2,004
Periodontix,       Series A
 Inc.              Preferred
                   shares      12/93     100,000      100,000    245,000     100,000     245,000
Periodontix,       Series B
 Inc.              Preferred
                   shares      02/96      67,000      134,000    164,150     134,000     164,150

Environmental
- -------------
Naiad Technologies,Series A
 Inc.              Preferred
                   shares      12/95      50,000       25,000    162,500      25,000     162,500
Naiad Technologies,Series B
 Inc.              Preferred 
                   Shares      11/96      62,602      125,204    203,457     125,204     203,457
Naiad Technologies,Series C
 Inc.              Preferred 
                   Shares      11/97      49,230      159,998    159,998     159,998     159,998

Venture Capital Limited Partnership Investments
- -----------------------------------------------
Medical Science    Limited
 Partners II, L.P. Partnership
                   Interests   various  $250,000      226,332    259,701     239,558     272,135
                                                    ---------  ---------   ---------   ---------

Total Equity Investments                           $4,208,359  5,671,650   5,011,218   6,481,986
                                                    =========  =========   =========   =========

 --   No investment held at end of period.
 0    Investment active with a carrying value or fair value of zero.



</TABLE>

Marketable Equity Securities
- ----------------------------

At December 31, 1998 and 1997, marketable equity securities had an 
aggregate cost of $984,268 and $1,084,621, respectively, and an 
aggregate fair value of $868,154 and $1,180,687, respectively.  The 
unrealized loss/gain at December 31, 1998 and 1997, included gross 
gains of $118,852 and $391,042, respectively. 

Acusphere, Inc.
- ---------------

In October 1998, the company had a new round of financing in which 
the Partnership did not participate.  The pricing of this round, in 
which third parties participated, indicated a fair value increase of 
$102,190 for the Partnership's existing investment.

ConjuChem, Inc. (formerly RedCell, Inc.)
- ---------------------------------------

In December 1998, the Partnership wrote off the remaining fair value 
and cost basis of its investment and realized a loss of $299,280.  
This was based on the opinion of the Managing General Partners that 
the operating status of the company indicated a permanent decline in 
value.

CV Therapeutics, Inc.
- ---------------------

In September 1998, the Partnership sold its common shares in the 
company for total proceeds of $157,011 and realized a loss of 
$330,213.

Prolinx, Inc.
- -------------

During 1998, the company had a new round of financing in which the 
Partnership did not participate. The pricing of this round, in which 
third parties participated, indicated an increase in fair value of 
$296,847 for the Partnership's existing investment.

Venture Capital Limited Partnership Investment
- ----------------------------------------------

The Partnership recorded a cost basis decrease of $13,226 as a 
result of stock distributions which were recorded as returns of 
capital from venture capital limited partnership investments in 
1998. 

Other Equity Investments
- ------------------------

Other significant changes reflected above relate to market value 
fluctuations or the elimination of a discount relating to selling 
restrictions for publicly traded portfolio companies.

Subsequent to December 31, 1998, the fair value of the Partnership's 
Endocare, Inc. investment increased to $730,800 as a result of an 
increase in the publicly traded market price at March 22, 1999.

6.  Change in Net Unrealized Fair Value of Equity Investments
    ---------------------------------------------------------

In accordance with the accounting policy as stated in Note 1, the 
Statements of Operations include a line item entitled "Change in net 
unrealized fair value of equity investments. "  The table below 
discloses details of the changes:

<TABLE>
<CAPTION>

                                 For the Years Ended December 31,
                               ------------------------------------

                                 1998          1997          1996
                               --------      --------      --------
<S>                          <C>             <C>           <C>   

(Decrease) increase in 
 fair value from cost of
 marketable equity
 securities                  $ (116,114)      96,066       (337,773)

Increase in fair value from
 cost of non-marketable 
 equity securities            1,579,405    1,374,702        707,257
                              ---------    ---------        -------

 Net unrealized fair 
  value increase from
  cost at end of year         1,463,291    1,470,768        369,484

 Net unrealized fair value
  increase (decrease) from
  cost at beginning of year   1,470,768      369,484         (8,477)
                              ---------    ---------        -------

Change in net unrealized
 fair value of equity
 investments                 $   (7,477)   1,101,284        377,961
                              =========    =========        =======

</TABLE>

7.  Cash and Cash Equivalents
    -------------------------

Cash and cash equivalents at December 31, 1998 and 1997,
consisted of:

<TABLE>
<CAPTION>
                                              1998        1997
                                             ------      ------

<S>                                       <C>           <C>

Demand accounts                               $263        3,470
Money-market accounts                          124      153,667
                                               ---      -------

  Total                                       $387      157,137
                                          ===      =======

</TABLE>

8.  Short-Term Borrowings
   ---------------------

The Partnership has a borrowing account with a financial 
institution.  At December 31, 1998, the borrowing capacity of this 
account, which fluctuates based on collateral value, was $285,137; 
as of March 26, 1999, the borrowing capacity was $0 and the 
outstanding balance was $241,800.  The Partnership, if required to 
by the lender, intends to repay this borrowing from the proceeds of 
investment sales or support from the Managing General Partners.  
Interest is charged at the prime rate plus one half percent.  The 
weighted-average interest rate for the year ended December 31, 1998 
was 8.75%.  Interest expense was $3,441 for the year ended December 
31, 1998.  The Partnership's investments in Megabios Corp., and Axys 
Pharmaceuticals, Inc. are pledged as collateral.

9.  Commitments
    -----------

The Partnership is a party to financial instruments with off-
balance-sheet risk in the normal course of its business.  Generally, 
these instruments are commitments for future equity fundings, 
venture capital limited partnership investments, equipment financing 
commitments, or accounts receivable lines of credit that are 
outstanding but not currently fully utilized.  As they do not 
represent current outstanding balances, these unfunded commitments 
are properly not recognized in the financial statements.  At 
December 31, 1998, the Partnership had no unfunded commitments.

The Partnership uses the same credit policies in making these 
commitments and conditional obligations as it does for on-balance-
sheet instruments.  Commitments to extend financing are agreements 
to lend to a company as long as there are no violations of any 
conditions established in the contract.  The credit lines generally 
have fixed termination dates or other termination clauses.  Since 
many of the commitments are expected to expire without being fully 
drawn upon, the total commitment amounts do not necessarily 
represent future cash requirements. 


<PAGE>

                              SIGNATURES
                              ----------

Pursuant to the requirements of Section 13 or 15(d) of the 
Securities Exchange Act of 1934, the Registrant has duly caused this 
Report to be signed on its behalf by the undersigned, thereunto duly 
authorized.


                      TECHNOLOGY FUNDING MEDICAL PARTNERS I, L.P.

                           By:  TECHNOLOGY FUNDING INC.
                                Managing General Partner


Date:  March 29, 1999      By:     /s/Michael Brenner
                                ------------------------------
                                      Michael Brenner
                                      Controller

Pursuant to the requirements of the Securities Exchange Act of 1934, 
this Report has been signed below by the following persons on behalf 
of the Registrant and in the capacities and on the dates indicated:

          Signature         Capacity                   Date
          ---------         --------                   ----

 /s/Charles R. Kokesh      President, Chief        March 29, 1999
- ------------------------   Executive Officer,
    Charles R. Kokesh      Chief Financial 
                           Officer and Chairman of
                           Technology Funding Inc.
                           and Managing General
                           Partner of Technology
                           Funding Ltd.


The above represents the Board of Directors of Technology Funding 
Inc. and the General Partners of Technology Funding Ltd.




<TABLE> <S> <C>

<ARTICLE>6
<LEGEND> THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION 
EXTRACTED FROM THE FORM 10-K AS OF DECEMBER 31, 1998, AND IS 
QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
<MULTIPLIER>1
       
<FISCAL-YEAR-END>             DEC-31-1998
<PERIOD-START>                JAN-01-1998
<PERIOD-END>                  DEC-31-1998
<PERIOD-TYPE>                        YEAR
<INVESTMENTS-AT-COST>           4,208,359
<INVESTMENTS-AT-VALUE>          5,671,650
<RECEIVABLES>                           0
<ASSETS-OTHER>                        920
<OTHER-ITEMS-ASSETS>                  387
<TOTAL-ASSETS>                  5,672,957
<PAYABLE-FOR-SECURITIES>                0
<SENIOR-LONG-TERM-DEBT>                 0
<OTHER-ITEMS-LIABILITIES>         325,492
<TOTAL-LIABILITIES>               325,492
<SENIOR-EQUITY>                         0
<PAID-IN-CAPITAL-COMMON>        3,884,174
<SHARES-COMMON-STOCK>              79,716
<SHARES-COMMON-PRIOR>              79,716
<ACCUMULATED-NII-CURRENT>               0
<OVERDISTRIBUTION-NII>                  0
<ACCUMULATED-NET-GAINS>                 0
<OVERDISTRIBUTION-GAINS>                0
<ACCUM-APPREC-OR-DEPREC>        1,463,291
<NET-ASSETS>                    5,347,465
<DIVIDEND-INCOME>                  15,967
<INTEREST-INCOME>                     693
<OTHER-INCOME>                          0
<EXPENSES-NET>                    615,998
<NET-INVESTMENT-INCOME>          (599,338)
<REALIZED-GAINS-CURRENT>         (630,940)
<APPREC-INCREASE-CURRENT>          (7,477)
<NET-CHANGE-FROM-OPS>          (1,237,755)
<EQUALIZATION>                          0
<DISTRIBUTIONS-OF-INCOME>               0
<DISTRIBUTIONS-OF-GAINS>                0
<DISTRIBUTIONS-OTHER>                   0
<NUMBER-OF-SHARES-SOLD>                 0
<NUMBER-OF-SHARES-REDEEMED>             0
<SHARES-REINVESTED>                     0
<NET-CHANGE-IN-ASSETS>         (1,237,755)
<ACCUMULATED-NII-PRIOR>                 0
<ACCUMULATED-GAINS-PRIOR>               0
<OVERDISTRIB-NII-PRIOR>                 0
<OVERDIST-NET-GAINS-PRIOR>              0
<GROSS-ADVISORY-FEES>             158,597
<INTEREST-EXPENSE>                      0
<GROSS-EXPENSE>                   616,598
<AVERAGE-NET-ASSETS>            5,966,342
<PER-SHARE-NAV-BEGIN>                  64
<PER-SHARE-NII>                       (15)
<PER-SHARE-GAIN-APPREC>                 0 <F1>
<PER-SHARE-DIVIDEND>                    0
<PER-SHARE-DISTRIBUTIONS>               0
<RETURNS-OF-CAPITAL>                    0
<PER-SHARE-NAV-END>                    49
<EXPENSE-RATIO>                      10.3
<AVG-DEBT-OUTSTANDING>                  0
<AVG-DEBT-PER-SHARE>                    0
<FN>
<F1>
A zero value is used since the change in net unrealized fair value 
is not allocated to General Partners and Limited Partners as it is 
not taxable.
</FN>

</TABLE>


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