ENDOGEN INC
S-8, 1999-02-24
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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As filed with the Securities and Exchange Commission on February 24, 1999

                                                     Registration No. 333-______
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              --------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      under
                           THE SECURITIES ACT OF 1933

                                  ENDOGEN, INC.
             (Exact name of registrant as specified in its charter)

<TABLE>
<S>                                                                  <C>
                        Massachusetts                                             04-2789249
(State or other jurisdiction of incorporation or organization)       (I.R.S. Employer Identification No.)
            30 Commerce Way, Woburn, Massachusetts                                  01801   
           (Address of Principal Executive Offices)                               (Zip Code)
</TABLE>
                              --------------------

                                 1992 STOCK PLAN
                            (Full title of the plan)

                                 Owen A. Dempsey
                                  ENDOGEN, INC.
                                 30 Commerce Way
                                Woburn, MA 01801
                     (Name and address of agent for service)

                                 (781) 937-0890
          (Telephone number, including area code, of agent for service)

                              --------------------

                                    Copy to:
                             William J. Schnoor, Jr.
                         Testa, Hurwitz & Thibeault, LLP
                                High Street Tower
                                 125 High Street
                           Boston, Massachusetts 02110
                                 (617) 248-7000

                              --------------------

                         Calculation of Registration Fee

<TABLE>
<CAPTION>
====================================================================================================================================
   Title of Securities      Amount to be       Proposed maximum offering   Proposed maximum aggregate   Amount of registration fee
    to be registered         registered             price per share              offering price
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                          <C>                       <C>                       <C>                             <C>
    Common Stock,
    par value $.01            3,970(1)                 $2.50(1)                    $9,925.00(1)                    $2.76
    Common Stock,
    par value $.01           246,030(2)                $3.03(2)                  $745,470.90(2)                  $207.24
                             -------                                             -----------                     -------

TOTAL:                       250,000                                             $755,395.90                     $210.00
                             =======                                             ===========                     =======
====================================================================================================================================
</TABLE>

     (1) All such shares are issuable upon exercise of outstanding options to
purchase an aggregate of 3,970 shares at an exercise price of $2.50 per share.
Pursuant to Regulation C, Rule 457(h)(1) under the Securities Act of 1933, as
amended, the aggregate offering price and fee have been computed upon the basis
of the price at which the options may be exercised.

     (2) Pursuant to Regulation C, Rule 457(h)(1) under the Securities Act of
1933, as amended, the price of $3.03 per share ,which is the average of the high
and low prices of the Common Stock as reported on the Nasdaq SmallCap Market on
February 19, 1999, is set forth solely for the purpose of calculating the filing
fee.

<PAGE>

                                      -2-

     This Registration Statement registers additional securities of the same
class as other securities for which Registration Statement No. 33-64440 on Form
S-8 as filed with the Securities and Exchange Commission on June 15, 1993,
Registration Statement No. 33-77576 on Form S-8 as filed with the Securities and
Exchange Commission on April 11, 1994, and Registration Statement No. 333-58985
on Form S-8 as filed with Securities and Exchange Commission on July 13, 1998,
relating to the Endogen, Inc. 1992 Stock Plan, are effective. Pursuant to
General Instruction E, the contents of the above-listed Registration Statements
are hereby incorporated by reference.

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 8.  Exhibits
         --------

<TABLE>
Exhibit No.    Description of Exhibit
- -----------    ----------------------

<S>            <C>
4.1            1992 Stock Plan of the Registrant, as amended November 5, 1998

4.2            By-Laws, as amended on July 30, 1998 (filed as Exhibit 3.1 to the
               Company's Quarterly Report on Form 10-QSB for the quarter ended
               August 31, 1998 and incorporated herein by reference)

5.1            Opinion of Testa, Hurwitz & Thibeault, LLP.

23.1           Consent of PricewaterhouseCoopers LLP.

23.2           Consent of Testa, Hurwitz & Thibeault, LLP (included in
               Exhibit 5.1).

24.1           Power of Attorney (contained in Page 3 of this Registration
               Statement).
</TABLE>
<PAGE>
                                      -3-

                                   SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Woburn, Commonwealth of Massachusetts, on the 23rd
day of February, 1999.

                                       ENDOGEN, Inc.

                                       By: /s/ Owen A. Dempsey
                                           --------------------------------
                                           Owen A. Dempsey
                                           President and Chief Executive Officer

                        POWER OF ATTORNEY AND SIGNATURES

We, the undersigned officers and directors of Endogen, Inc., hereby severally
constitute and appoint Owen A. Dempsey, Avery W. Catlin, and William J. Schnoor,
Jr., and each of them singly, our true and lawful attorneys, with full power to
them and each of them singly, to sign for us in our names in the capacities
indicated below, all pre-effective and post-effective amendments to this
registration statement and generally do all things in our names and on our
behalf in such capacities to enable Endogen, Inc., to comply with the provisions
of the Securities Act of 1933, as amended and all requirements of the Securities
and Exchange Commission.

Pursuant to the requirements of the Securities Act of 1933, as amended, this
registration statement has been signed below by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
Signature                                        Title(s)                                              Date:
- ---------                                        --------                                              -----
<S>                                              <C>                                               <C> 
/s/ Owen A. Dempsey                              Director, President, and                          February 23, 1999
- -----------------------                          Chief Executive Officer
Owen A. Dempsey                                  (Principal Executive Officer)

/s/ Wallace G. Dempsey                           Director                                          February 23, 1999
- ----------------------
Wallace G. Dempsey

/s/ Irwin Gruverman                              Director                                          February 23, 1999
- ----------------------
Irwin Gruverman

/s/ Hayden H. Harris                             Director                                          February 23, 1999
- ----------------------
Hayden H. Harris

/s/ Wolfgang Woloszczuk                          Director                                          February 23, 1999
- ----------------------
Wolfgang Woloszczuk

/s/ Charles R. Burke                             Director                                          February 23, 1999
- ----------------------
Charles R. Burke

/s/ Avery W. Catlin                              Vice President, Operations and Finance,           February 23, 1999
- ----------------------                           Chief Financial Officer, Treasurer and
Avery W. Catlin                                  Clerk (Principal Financial and Accounting
                                                 Officer)
</TABLE>
<PAGE>



                                  EXHIBIT INDEX
                                  -------------

<TABLE>
Exhibit No.   Description of Exhibit
- -----------   ----------------------
<S>           <C>
4.1           1992 Stock Plan of the Registrant, as amended November 5, 1998

4.2           By-Laws, as amended on July 30, 1998 (filed as Exhibit 3.1 to the
              Company's Quarterly Report on Form 10-QSB for the quarter ended
              August 31, 1998 and incorporated herein by reference)

5.1           Opinion of Testa, Hurwitz & Thibeault, LLP

23.1          Consent of PricewaterhouseCoopers LLP

23.2          Consent of Testa, Hurwitz & Thibeault, LLP (included in
              Exhibit 5.1)

24.1          Power of Attorney (contained in Page 3 of this Registration
              Statement)
</TABLE>



                                   Exhibit 4.1


                                  ENDOGEN, INC.

                                 1992 STOCK PLAN
                                 ---------------

     1. Purpose. This 1992 Stock Plan (the "Plan") is an amendment and
restatement of the 1989 Stock Plan of Endogen, Inc. (the "Company") and is
intended to provide incentives: (a) to the officers and other employees of the
Company, its parent (if any) and any present or future subsidiaries of the
Company (collectively, "Related Corporations") by providing them with
opportunities to purchase stock in the Company pursuant to options granted
hereunder which qualify as "incentive stock options" under Section 422(b) of the
Internal Revenue Code of 1986, as amended (the "Code") ("ISO" or "ISOs"); (b) to
directors, officers, employees and consultants of the Company and Related
Corporations by providing them with opportunities to purchase stock in the
Company pursuant to options granted hereunder which do not qualify as ISOs
("Non-Qualified Option" or "Non-Qualified Options"); (c) to directors, officers,
employees and consultants of the Company and Related Corporations by providing
them with awards of stock in the Company ("Awards"); and (d) to directors,
officers, employees and consultants of the Company and Related Corporations by
providing them with opportunities to make direct purchases of stock in the
Company ("Purchases"). Both ISOs and Non-Qualified Options are referred to
hereafter individually as an "Option" and collectively as "Options". Options,
Awards and authorizations to make Purchases are referred to hereafter
collectively as "Stock Rights". As used herein, the terms "parent" and
"subsidiary" mean "parent corporation" and "subsidiary corporation",
respectively, as those terms are defined in Section 424 of the Code.

     2. Administration of the Plan.

     A. Board or Committee Administration. The Plan shall be administered by the
  Board of Directors of the Company (the "Board") or, subject to paragraph 2(D)
  (relating to compliance with Section 162(m) of the Code), by a committee
  appointed by the Board (the "Committee"); provided, that, to the extent
  required by Rule 16b-3, or any successor provision ("Rule 16b-3"), of the
  Securities Exchange Act of 1934, with respect to specific grants of Stock
  Rights, the Plan shall be administered by a disinterested administrator or
  administrators within the meaning of Rule 16b-3. Hereinafter, all references
  in this Plan to the "Committee" shall mean the Board if no Committee has been
  appointed. Subject to ratification of the grant or authorization of each Stock
  Right by the Board (if so required by applicable state law), and subject to
  the terms of the Plan, the Committee shall have the authority to (i) determine
  the employees of the Company and Related Corporations (from among the class of
  employees eligible under paragraph 3 to receive ISOs) to whom ISOs may be
  granted, and to determine (from among the class of individuals and entities
  eligible under paragraph 3 to receive Non-Qualified Options and Awards and to
  make Purchases) to whom Non-Qualified Options, Awards and authorizations to
  make Purchases may be granted; (ii) determine the time or times at which
  Options or Awards may be granted or Purchases made; (iii) determine the option
  price of shares subject to each Option, which price shall not be less than the
  minimum price specified in paragraph 6, and the purchase price of shares
  subject to each Purchase; (iv) determine whether each Option granted shall be
  an ISO or a Non-Qualified Option; (v) determine (subject to paragraphs 7 and
  9) the time or times when each Option shall become exercisable and the
  duration of the exercise period; (vi) determine whether restrictions such as
  repurchase options are to be imposed on shares subject to Options, Awards and
  Purchases and the nature of such restrictions, if any, and (vii) interpret the
  Plan and prescribe and rescind rules and regulations relating to it. If the
  Committee determines to issue a Non-Qualified Option, it shall take whatever
  actions it deems necessary, under Section 422 of the Code and the regulations
  promulgated thereunder, to ensure that such Option is not treated as an ISO.
  The interpretation and construction by the Committee of any provisions of the
  Plan or of any Stock Right granted under it shall be final unless otherwise
  determined by the Board. The Committee may from time to time adopt such rules
  and regulations for carrying out the Plan as it may deem best. No member of
  the Board or the Committee shall be liable for any action or determination
  made in good faith with respect to the Plan or any Stock Right granted under
  it.

<PAGE>

     B. Committee Actions. The Committee may select one of its members as its
  chairman, and shall hold meetings at such times and places as it may
  determine. Acts by a majority of the Committee, or acts reduced to or approved
  in writing by a majority of the members of the Committee (if consistent with
  applicable state law), shall be the valid acts of the Committee. From time to
  time the Board may increase the size of the Committee and appoint additional
  members thereof, remove members (with or without cause) and appoint new
  members in substitution therefor, fill vacancies however caused, or remove all
  members of the Committee and thereafter directly administer the Plan.

     C. Grant of Stock Rights to Board Members. Stock Rights may be granted to
  members of the Board consistent with the provisions of the first sentence of
  paragraph 2(A) above, if applicable. All grants of Stock Rights to members of
  the Board shall in all other respects be made in accordance with the
  provisions of this Plan applicable to other eligible persons. Members of the
  Board who are either (i) eligible for Stock Rights pursuant to the Plan or
  (ii) have been granted Stock Rights may vote on any matters affecting the
  administration of the Plan or the grant of any Stock Rights pursuant to the
  Plan, except that no such member shall act upon the granting to himself of
  Stock Rights, but any such member may be counted in determining the existence
  of a quorum at any meeting of the Board during which action is taken with
  respect to the granting to him of Stock Rights.

     D. Performance-Based Compensation. The Board, in its discretion, may take
  such action as may be necessary to ensure that Stock Rights granted under the
  Plan qualify as "qualified performance-based compensation" within the meaning
  of Section 162(m) of the Code and applicable regulations promulgated
  thereunder ("Performance-Based Compensation"). Such action may include, in the
  Board's discretion, some or all of the following (i) if the Board determines
  that Stock Rights granted under the Plan generally shall constitute
  Performance-Based Compensation, the Plan shall be administered, to the extent
  required for such Stock Rights to constitute Performance-Based Compensation,
  by a Committee consisting solely of two or more "outside directors" (as
  defined in applicable regulations promulgated under Section 162(m) of the
  Code), (ii) if any Non-Qualified Options with an exercise price less than the
  fair market value per share of Common Stock are granted under the Plan and the
  Board determines that such Options should constitute Performance-Based
  Compensation, such options shall be made exercisable only upon the attainment
  of a pre-established, objective performance goal established by the Committee,
  and such grant shall be submitted for, and shall be contingent upon
  shareholder approval and (iii) Stock Rights granted under the Plan may be
  subject to such other terms and conditions as are necessary for compensation
  recognized in connection with the exercise or disposition of such Stock Right
  or the disposition of Common Stock acquired pursuant to such Stock Right, to
  constitute Performance-Based Compensation.

     3. Eligible Employees and Others. ISOs may be granted to any employee of
the Company or any Related Corporation. Those officers and directors of the
Company who are not employees may not be granted ISOs under the Plan.
Non-Qualified Options, Awards and authorizations to make Purchases may be
granted to any employee, officer or director (whether or not also an employee)
or consultant of the Company or any Related Corporation. The Committee may take
into consideration a recipient's individual circumstances in determining whether
to grant an ISO, a Non-Qualified Option, an Award or an authorization to make a
Purchase. Granting of any Stock Right to any individual or entity shall neither
entitle that individual or entity to, nor disqualify him from, participation in
any other grant of Stock Rights.

     4. Stock. The stock subject to Options, Awards and Purchases shall be
authorized but unissued shares of Common Stock of the Company, par value $.01
per share (the "Common Stock"), or shares of Common Stock reacquired by the
Company in any manner. The aggregate number of shares which may be issued
pursuant to the Plan is 1,250,000, subject to adjustment as provided in
paragraph 13. Any such shares may be issued pursuant to any type of Stock Rights
granted under the Plan, so long as the number of shares so issued does not
exceed such number, as adjusted. If any Stock Right granted under the Plan shall
expire or terminate for any reason without having been exercised in full or
shall cease for any reason to be exercisable in whole or in part, the
unpurchased shares subject to such Stock Right shall again be available for
grants of Stock Rights under the Plan.

<PAGE>

     No employee of the Company or any Related Corporation may be granted Stock
Rights to acquire, in the aggregate, more than 200,000 shares of Common Stock
under the Plan during any fiscal year of the Company. If any Stock Right granted
under the Plan shall expire or terminate for any reason without having been
exercised in full or shall cease for any reason to be exercisable in whole or in
part or shall be repurchased by the Company, the shares subject to such Stock
Right shall be included in the determination of the aggregate number of shares
of Common Stock deemed to have been granted to such employee under the Plan.


     5. Granting of Stock Rights. Stock Rights may be granted under the Plan at
any time after August 10, 1992 and prior to August 9, 2002. The date of grant of
a Stock Right under the Plan will be the date specified by the Committee at the
time it grants the Stock Right; provided, however, that such date shall not be
prior to the date on which the Committee acts to approve the grant. The
Committee shall have the right, with the consent of the optionee, to convert an
ISO granted under the Plan to a Non-Qualified Option pursuant to paragraph 16.

     6. Minimum Option Price; ISO Limitations.

     A. Price for Non-Qualified Options. Subject to paragraph 2(D) (relating to
  compliance with Section 162(m) of the Code), the exercise price per share
  specified in the agreement relating to each Non-Qualified Option granted under
  the Plan shall in no event be less than the minimum legal consideration
  required therefor under the laws of the Commonwealth of Massachusetts or the
  laws of any jurisdiction in which the Company or its successors in interest
  may be organized.

     B. Price for ISOs. The exercise price per share specified in the agreement
  relating to each ISO granted under the Plan shall not be less than the fair
  market value per share of Common Stock on the date of such grant. In the case
  of an ISO to be granted to an employee owning stock possessing more than ten
  percent (10%) of the total combined voting power of all classes of stock of
  the Company or any Related Corporation, the price per share specified in the
  agreement relating to such ISO shall not be less than one hundred ten percent
  (110%) of the fair market value per share of Common Stock on the date of
  grant. For purposes of determining stock ownership under this paragraph, the
  rules of Section 424(d) of the Code shall apply.

     C. $100,000 Annual Limitation on ISO Vesting. Each eligible employee may be
  granted Options treated as ISOs only to the extent that, in the aggregate
  under this Plan and all incentive stock option plans of the Company and any
  Related Corporation, ISOs do not become exercisable for the first time by such
  employee during any calendar year with respect to stock having a fair market
  value (determined at the time the ISOs were granted) in excess of $100,000.
  The Company intends to designate any Options granted in excess of such
  limitation as Non-Qualified Options.

     D. Determination of Fair Market Value. If, at the time an Option is granted
  under the Plan, the Company's Common Stock is publicly traded, "fair market
  value" shall be determined as of the last business day for which the prices or
  quotes discussed in this sentence are available prior to the date such Option
  is granted and shall mean (i) the average (on that date) of the high and low
  prices of the Common Stock on the principal national securities exchange on
  which the Common Stock is traded, if the Common Stock is then traded on a
  national securities exchange; or (ii) the last reported sale price (on that
  date) of the Common Stock on the Nasdaq National Market List, if the Common
  Stock is not then traded on a national securities exchange; or (iii) the
  closing bid price (or average of bid prices) last quoted (on that date) by an
  established quotation service for over-the-counter securities, if the Common
  Stock is not reported on the Nasdaq National Market List. However, if the
  Common Stock is not publicly traded at the time an Option is granted under the
  Plan, "fair market value" shall be deemed to be the fair value of the Common
  Stock as determined by the Committee after taking into consideration all
  factors which it deems appropriate, including, without limitation, recent sale
  and offer prices of the Common Stock in private transactions negotiated at
  arm's length.

     7. Option Duration. Subject to earlier termination as provided in
paragraphs 9 and 10, each Option shall expire on the date specified by the
Committee, but not more than (i) ten years and one day from the date of grant in
the case of Non-Qualified Options, (ii) ten years from the date of grant in the
case of ISOs generally, and (iii) five years from the date of grant in the case
of ISOs granted to an employee owning stock possessing more than

<PAGE>

ten percent (10%) of the total combined voting power of all classes of stock of
the Company or any Related Corporation, as determined under paragraph 6(B).
Subject to earlier termination as provided in paragraphs 9 and 10, the term of
each ISO shall be the term set forth in the original instrument granting such
ISO, except with respect to any part of such ISO that is converted into a
Non-Qualified Option pursuant to paragraph 16.

     8. Exercise of Option. Subject to the provisions of paragraphs 9 through
12, each Option granted under the Plan shall be exercisable as follows:

     A. Vesting. The Option shall either be fully exercisable on the date of
  grant or shall become exercisable thereafter in such installments as the
  Committee may specify.

     B. Full Vesting of Installments. Once an installment becomes exercisable it
  shall remain exercisable until expiration or termination of the Option, unless
  otherwise specified by the Committee.

     C. Partial Exercise. Each Option or installment may be exercised at any
  time or from time to time, in whole or in part, for up to the total number of
  shares with respect to which it is then exercisable.

     D. Acceleration of Vesting. The Committee shall have the right to
  accelerate the date of exercise of any installment of any Option; provided
  that the Committee shall not, without the consent of an optionee, accelerate
  the exercise date of any installment of any Option granted to any employee as
  an ISO (and not previously converted into a Non-Qualified Option pursuant to
  paragraph 16) if such acceleration would violate the annual vesting limitation
  contained in Section 422(d) of the Code, as described in paragraph 6(C).

     9. Termination of Employment. If an ISO optionee ceases to be employed by
the Company and all Related Corporations other than by reason of death or
disability as defined in paragraph 10, no further installments of his ISOs shall
become exercisable, and his ISOs shall terminate after the passage of ninety
(90) days from the date of termination of his employment, but in no event later
than on their specified expiration dates, except to the extent that such ISOs
(or unexercised installments thereof) have been converted into Non-Qualified
Options pursuant to paragraph 16. For purposes of this paragraph 9 only,
employment shall be considered as continuing uninterrupted during any bona fide
leave of absence (such as those attributable to illness, military obligations or
governmental service) provided that the period of such leave does not exceed 90
days or, if longer, any period during which such optionee's right to
re-employment is guaranteed by statute. A bona fide leave of absence with the
written approval of the Committee shall not be considered an interruption of
employment under this paragraph 9, provided that such written approval
contractually obligates the Company or any Related Corporation to continue the
employment of the optionee after the approved period of absence. ISOs granted
under the Plan shall not be affected by any change of employment within or among
the Company and Related Corporations, so long as the optionee continues to be an
employee of the Company or any Related Corporation. Nothing in the Plan shall be
deemed to give any grantee of any Stock Right the right to be retained in
employment or other service by the Company or any Related Corporation for any
period of time.

     10. Death; Disability.

     A. Death. If an ISO optionee ceases to be employed by the Company and all
  Related Corporations by reason of his death, any ISO of his may be exercised,
  to the extent of the number of shares with respect to which he could have
  exercised it on the date of his death, by his estate, personal representative
  or beneficiary who has acquired the ISO by will or by the laws of descent and
  distribution, at any time prior to the earlier of the specified expiration
  date of the ISO or 180 days from the date of the optionee's death.

     B. Disability. If an ISO optionee ceases to be employed by the Company and
  all Related Corporations by reason of his disability, he shall have the right
  to exercise any ISO held by him on the date of termination of employment, to
  the extent of the number of shares with respect to which he could have
  exercised it on that date, at any time prior to the earlier of the specified
  expiration date of the ISO or 180 days from the date of the termination of the
  optionee's employment. For the purposes of the Plan, the term "disability"
  shall mean "permanent and total disability" as defined in Section 22(e)(3) of
  the Code or successor statute.

<PAGE>

     11. Assignability. No Stock Right shall be assignable or transferable by
the grantee except by will or by the laws of descent and distribution. During
the lifetime of the grantee each Stock Right shall be exercisable only by him.

     12. Terms and Conditions of Options. Options shall be evidenced by
instruments (which need not be identical) in such forms as the Committee may
from time to time approve. Such instruments shall conform to the terms and
conditions set forth in paragraphs 6 through 11 hereof and may contain such
other provisions as the Committee deems advisable which are not inconsistent
with the Plan, including restrictions applicable to shares of Common Stock
issuable upon exercise of Options. In granting any Non-Qualified Option, the
Committee may specify that such Non-Qualified Option shall be subject to the
restrictions set forth herein with respect to ISOs, or to such other termination
and cancellation provisions as the Committee may determine. The Committee may
from time to time confer authority and responsibility on one or more of its own
members and/or one or more officers of the Company to execute and deliver such
instruments. The proper officers of the Company are authorized and directed to
take any and all action necessary or advisable from time to time to carry out
the terms of such instruments.

     13. Adjustments. Upon the occurrence of any of the following events, an
optionee's rights with respect to Options granted to him hereunder shall be
adjusted as hereinafter provided, unless otherwise specifically provided in the
written agreement between the optionee and the Company relating to such Option:

     A. Stock Dividends and Stock Splits. If the shares of Common Stock shall be
  subdivided or combined into a greater or smaller number of shares or if the
  Company shall issue any shares of Common Stock as a stock dividend on its
  outstanding Common Stock, the number of shares of Common Stock deliverable
  upon the exercise of Options shall be appropriately increased or decreased
  proportionately, and appropriate adjustments shall be made in the purchase
  price per share to reflect such subdivision, combination or stock dividend.

     B. Consolidations or Mergers. If the Company is to be consolidated with or
  acquired by another entity in a merger, sale of all or substantially all of
  the Company's assets or otherwise (an "Acquisition"), the Committee or the
  board of directors of any entity assuming the obligations of the Company
  hereunder (the "Successor Board"), shall, as to outstanding Options, either
  (i) make appropriate provision for the continuation of such Options by
  substituting on an equitable basis for the shares then subject to such Options
  the consideration payable with respect to the outstanding shares of Common
  Stock in connection with the Acquisition; or (ii) upon written notice to the
  optionees, provide that all Options must be exercised, to the extent then
  exercisable, within a specified number of days of the date of such notice, at
  the end of which period the Options shall terminate; or (iii) terminate all
  Options in exchange for a cash payment equal to the excess of the fair market
  value of the shares subject to such Options (to the extent then exercisable)
  over the exercise price thereof.

     C. Recapitalization or Reorganization. In the event of a recapitalization
  or reorganization of the Company (other than a transaction described in
  subparagraph B above) pursuant to which securities of the Company or of
  another corporation are issued with respect to the outstanding shares of
  Common Stock, an optionee upon exercising an Option shall be entitled to
  receive for the purchase price paid upon such exercise the securities he would
  have received if he had exercised his Option prior to such recapitalization or
  reorganization.

     D. Modification of ISOs. Notwithstanding the foregoing, any adjustments
  made pursuant to subparagraphs A, B or C with respect to ISOs shall be made
  only after the Committee, after consulting with counsel for the Company,
  determines whether such adjustments would constitute a "modification" of such
  ISOs (as that term is defined in Section 424 of the Code) or would cause any
  adverse tax consequences for the holders of such ISOs. If the Committee
  determines that such adjustments made with respect to ISOs would constitute a
  modification of such ISOs, it may refrain from making such adjustments.

<PAGE>

     E. Dissolution or Liquidation. In the event of the proposed dissolution or
  liquidation of the Company, each Option will terminate immediately prior to
  the consummation of such proposed action or at such other time and subject to
  such other conditions as shall be determined by the Committee.

     F. Issuances of Securities. Except as expressly provided herein, no
  issuance by the Company of shares of stock of any class, or securities
  convertible into shares of stock of any class, shall affect, and no adjustment
  by reason thereof shall be made with respect to, the number or price of shares
  subject to Options. No adjustments shall be made for dividends paid in cash or
  in property other than securities of the Company.

     G. Fractional Shares. No fractional shares shall be issued under the Plan
  and the optionee shall receive from the Company cash in lieu of such
  fractional shares.

     H. Adjustments. Upon the happening of any of the events described in
  subparagraphs A, B or C above, the class and aggregate number of shares set
  forth in paragraph 4 hereof that are subject to Stock Rights which previously
  have been or subsequently may be granted under the Plan shall also be
  appropriately adjusted to reflect the events described in such subparagraphs.
  The Committee or the Successor Board shall determine the specific adjustments
  to be made under this paragraph 13 and, subject to paragraph 2, its
  determination shall be conclusive.

     If any person or entity owning restricted Common Stock obtained by exercise
of a Stock Right made hereunder receives shares or securities or cash in
connection with a corporate transaction described in subparagraphs A, B or C
above as a result of owning such restricted Common Stock, such shares or
securities or cash shall be subject to all of the conditions and restrictions
applicable to the restricted Common Stock with respect to which such shares or
securities or cash were issued, unless otherwise determined by the Committee or
the Successor Board.

     14. Means of Exercising Stock Rights. A Stock Right (or any part or
installment thereof) shall be exercised by giving written notice to the Company
at its principal office address. Such notice shall identify the Stock Right
being exercised and specify the number of shares as to which such Stock Right is
being exercised, accompanied by full payment of the purchase price therefor
either (a) in United States dollars in cash or by check, or (b) at the
discretion of the Committee, through delivery of shares of Common Stock having a
fair market value equal as of the date of the exercise to the cash exercise
price of the Stock Right, (c) at the discretion of the Committee, by delivery of
the grantee's personal recourse note bearing interest payable not less than
annually at no less than 100% of the lowest applicable Federal rate, as defined
in Section 1274(d) of the Code, (d) at the discretion of the Committee and
consistent with applicable law, through the delivery of an assignment to the
Company of a sufficient amount of the proceeds from the sale of the Common Stock
acquired upon exercise of the Stock Right and an authorization to the broker or
selling agent to pay that amount to the Company, which sale shall be at the
participant's direction at the time of exercise, or (e) at the discretion of the
Committee, by any combination of (a), (b), (c) and (d) above. If the Committee
exercises its discretion to permit payment of the exercise price of an ISO by
means of the methods set forth in clauses (b), (c), (d) or (e) of the preceding
sentence, such discretion shall be exercised in writing at the time of the grant
of the ISO in question. The holder of a Stock Right shall not have the rights of
a shareholder with respect to the shares covered by his Stock Right until the
date of issuance of a stock certificate to him for such shares. Except as
expressly provided above in paragraph 13 with respect to changes in
capitalization and stock dividends, no adjustment shall be made for dividends or
similar rights for which the record date is before the date such stock
certificate is issued.

     15. Term and Amendment of Plan. This Plan was adopted by the Board of
Directors of the Company on August 10, 1992, subject to approval of the Plan by
the stockholders of the Company. The Plan shall expire at the end of the day on
August 9, 2002 (except as to Options outstanding on that date). The Board may
terminate or amend the Plan in any respect at any time, except that, without the
approval of the stockholders obtained within 12 months before or after the Board
adopts a resolution authorizing any of the following actions: (a) the total
number of shares that may be issued under the Plan may not materially be
increased (except by adjustment pursuant to paragraph 13); (b) the benefits
accruing to participants under the Plan may not materially be increased; (c) the
requirements as to eligibility to participate in the Plan may not materially be
modified; (d) the provisions of paragraph 3 regarding eligibility for grants of
ISOs may not be modified; (e) the provisions of paragraph 6(B)

<PAGE>

regarding the exercise price at which shares may be offered pursuant to ISOs may
not be modified (except by adjustment pursuant to paragraph 13); and (f) the
expiration date of the Plan may not be extended. Except as otherwise provided in
this paragraph 15, in no event may action of the Board or stockholders alter or
impair the rights of a grantee, without his consent, under any Stock Right
previously granted to him.

     16. Conversion of ISOs into Non-Qualified Options; Termination of ISOs. The
Committee, at the written request of any optionee, may in its discretion take
such actions as may be necessary to convert such optionee's ISOs (or any
installments or portions of installments thereof) that have not been exercised
on the date of conversion into Non-Qualified Options at any time prior to the
expiration of such ISOs, regardless of whether the optionee is an employee of
the Company or a Related Corporation at the time of such conversion. Such
actions may include, but shall not be limited to, extending the exercise period
or reducing the exercise price of the appropriate installments of such ISOs. At
the time of such conversion, the Committee (with the consent of the optionee)
may impose such conditions on the exercise of the resulting Non-Qualified
Options as the Committee in its discretion may determine, provided that such
conditions shall not be inconsistent with this Plan. Nothing in the Plan shall
be deemed to give any optionee the right to have such optionee's ISOs converted
into Non-Qualified Options, and no such conversion shall occur until and unless
the Committee takes appropriate action. The Committee, with the consent of the
optionee, may also terminate any portion of any ISO that has not been exercised
at the time of such termination.

     17. Application Of Funds. The proceeds received by the Company from the
sale of shares pursuant to Options granted and Purchases authorized under the
Plan shall be used for general corporate purposes.

     18. Notice to Company of Disqualifying Disposition. By accepting an ISO
granted under the Plan, each optionee agrees to notify the Company in writing
immediately after he/she (or any transferee to whom Section 424(c)(4) of the
Code, relating to transfers to a spouse or former spouse, applies) makes a
Disqualifying Disposition, as described in Sections 421, 422 and 424 of the Code
and regulations thereunder, of any stock acquired under the Plan (or stock or
securities received in a transaction described in Section 424(b) or 424(c)(1)(B)
of the Code, relating to distributions of stock with respect to stock acquired
under the Plan and certain tax-free exchanges of stock acquired under the Plan
for other stock or securities). A Disqualifying Disposition (with certain
exceptions) is generally any disposition within two years of the date the ISO
was granted or within one year of the date the ISO was exercised, whichever
period ends later. With respect to stock or securities held jointly with right
of survivorship, a termination of such joint tenancy may constitute a
Disqualifying Disposition. This paragraph 18 shall be made binding upon the
optionee and upon any transferee of stock or securities described in this
paragraph to whom Section 424(c)(4) of the Code applies.

     19. Withholding of Additional Income Taxes. Upon the exercise of a
Non-Qualified Option, the grant of an Award, the making of a Purchase of Common
Stock for less than its fair market value, the making of a Disqualifying
Disposition (as defined in paragraph 18), the vesting or transfer of restricted
stock acquired on the exercise of a Stock Right hereunder (or stock or
securities received in a transaction described in Section 424(b) or 424(c)(1)(B)
of the Code), or the making of a distribution or other payment with respect to
such stock or securities, the Company may withhold taxes in respect of amounts
that constitute compensation includible in gross income, whenever the Company
determines that such withholding is required. The Committee in its discretion
may condition (i) the exercise of an Option, (ii) the grant of an Award, (iii)
the making of a Purchase of Common Stock for less than its fair market value, or
(iv) the vesting of restricted Common Stock acquired by exercising a Stock
Right, on the grantee's making satisfactory arrangement for such withholding.

     20. Governmental Regulation. The Company's obligation to sell and deliver
shares of the Common Stock under this Plan is subject to the approval of any
governmental authority required in connection with the authorization, issuance
or sale of such shares.

     In addition to tax withholding, government regulations may impose reporting
or other obligations on the Company with respect to the Plan. For example, the
Company may be required to send tax information statements to employees and
former employees that exercise ISOs.

<PAGE>

     21. Compliance with Regulations. It is the Company's intent that the Plan
comply in all respects with Rule 16b-3 and any applicable Securities and
Exchange Commission interpretations thereof. If any provision of this Plan is
deemed not to be in compliance with Rule 16b-3, the provisions shall be null and
void.

     22. Governing Law; Construction. The validity and construction of the Plan
and the instruments evidencing Stock Rights shall be governed by the laws of the
Commonwealth of Massachusetts, or the laws of any jurisdiction in which the
Company or its successors in interest may be organized. In construing this Plan,
the singular shall include the plural and the masculine gender shall include the
feminine and neuter, unless the context otherwise requires.


                                           Exhibit 5.1








                                                              February 24, 1999


Endogen, Inc.
30 Commerce Way
Woburn, MA  01801

         RE:      Registration Statement on Form S-8 Relating to the
                  1992 Stock Plan (the "1992 Plan")

Dear Sir or Madam:

         Reference is made to the above-captioned Registration Statement on Form
S-8 (the "Registration Statement") filed by Endogen, Inc. (the "Company") on the
date hereof with the Securities and Exchange Commission under the Securities Act
of 1933, as amended, relating to an aggregate of 250,000 shares of Common Stock,
$.01 par value, of the Company issuable pursuant to the 1992 Plan (the
"Shares").

         We have examined, are familiar with, and have relied as to factual
matters solely upon, copies of the 1992 Plan, the Restated Articles of
Organization and Amended and Restated By-Laws of the Company, the minute books
and stock records of the Company and originals of such other documents,
certificates and proceedings as we have deemed necessary for the purpose of
rendering this opinion.

         Based on the foregoing, we are of the opinion that the Shares have been
duly authorized and, when issued and paid for in accordance with the terms of
the 1992 Plan, will be validly issued, fully paid and nonassessable.

         We hereby consent to the filing of this opinion as Exhibit 5.1 to the
Registration Statement.



                                          Very truly yours,

                                          /s/ Testa, Hurwitz & Thibeault, LLP
                                          -----------------------------------
                                          TESTA, HURWITZ & THIBEAULT, LLP



                                  Exhibit 23.1

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS



We hereby consent to the incorporation by reference in this Registration
Statement on Form S-8 of our report dated July 9, 1998 appearing on page F-2 of
Endogen Inc.'s Annual Report on Form 10-KSB for the year ended May 31, 1998.



/s/ PricewaterhouseCoopers LLP
- ------------------------------
PRICEWATERHOUSECOOPERS LLP



Boston, Massachusetts
February 23, 1999




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