ENDOGEN INC
SC 13G/A, 1999-02-08
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    ---------

                                  SCHEDULE 13G
                                 (Rule 13d-102)

           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
        RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT
                                  TO 13d-2(b)

                              (Amendment No. 5)(1)


                                  Endogen, Inc.
- -------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   29264J 10 8
- -------------------------------------------------------------------------------
                                 (CUSIP Number)

                               December 31, 1998
- -------------------------------------------------------------------------------
            (Date or Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ] Rule 13d-1(b)
[ ] Rule 13d-(c)
[X] Rule 13d-1(d)


- ----------------
(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>

- -------------------------                           ---------------------------
|CUSIP NO. 29264J 10 8  |           13G            |   Page  2  of   5  Pages  |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)          |
|        |                                                                     |
|        |  Wallace G. Dempsey                                                 |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |  Not Applicable                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States of America                                           |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        |                      190,000             |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        |                         0                |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    |  SOLE DISPOSITIVE POWER                  |
|       REPORTING          |        |                      190,000             |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    |  SHARED DISPOSITIVE POWER                |
|                          |        |                         0                |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        |                              190,000                                |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                           Not Applicable                            |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        |                               5.5%                                  |
|--------|- -------------------------------------------------------------------|
|  12    |  TYPE OF REPORTING PERSON*                                          |
|        |                                IN                                   |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 29264J 10 8  |           13G            |   Page  3  of   5  Pages  |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------


Item 1(a).    Name of Issuer:  Endogen, Inc.

Item 1(b).    Address of Issuer's Principal Executive Offices:
              30 Commerce Way, Woburn, MA  01801

Item 2(a).    Names of Person Filing: Wallace G. Dempsey

Item 2(b).    Address of Principal Business Office or, if None, Residence:
              487 Scarsdale Road, Crestwood, NY 10707

Item 2(c).    Citizenship: United States of America

Item 2(d).    Title of Class of Securities:  Common Stock, $.01 par value per
              share.

Item 2(e).    CUSIP Number:  29264J 10 8

Item 3.       If this statement is filed pursuant to Rules 13d-1(b),
              13d-2(b) or (c), check whether the person filing is a:

              (a) [ ] Broker or Dealer registered under Section 15 of the
                      Securities Exchange Act of 1934 (the "Act");

              (b) [ ] Bank as defined in Section 3(a)(6) of the Act;

              (c) [ ] Insurance Company as defined in Section 3(a)(19) of the
                      Act;

              (d) [ ] Investment Company registered under Section 8 of the
                      Investment Company Act;

              (e) [ ] An investment advisor in accordance with Rule
                      13d-1(b)(1)(ii)(E);

              (f) [ ] An employee benefit plan or endowment fund in accordance
                      with Rule 13d-1(b)(1)(ii)(F);

              (g) [ ] A parent holding company or control person, in accordance
                      with Rule 13d-1(b)(ii)(G);

              (h) [ ] A savings association as defined in Section 3(b) of the
                      Federal Deposit Insurance Act;

              (i) [ ] A church plan that is excluded from the definition of an
                      investment company under Section 3(c)(14) of the
                      Investment Company Act;

              (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

              If this statement is filed pursuant to Rule 13d-1(c), check this
              box. [ ]

              Not applicable

Item 4.       Ownership.

              (a) Amount Beneficially Owned: 190,000 shares. Represents 160,000
              shares of Endogen Common Stock and 30,000 shares issuable upon
              exercise of outstanding stock options exercisable on December 31,
              1998 or within 60 days thereafter.


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 29264J 10 8  |           13G            |   Page  4  of   5  Pages  |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------


              (b) Percent of Class:  5.5%

              (c) Number of shares as to which such person has:

                  (i)   sole power to vote or to direct the vote:
                                          -190,000-

                  (ii)  shared power to vote or to direct the vote:
                                          -0-

                  (iii) sole power to dispose or to direct the disposition of:
                                          -190,000-

                  (iv)  shared power to dispose or to direct the disposition of:
                                          -0-

Item 5.       Ownership of Five Percent or Less of a Class.

              Not applicable.

Item 6.       Ownership of More than Five Percent on Behalf of Another Person.

              Not applicable.

Item 7.       Identification and Classification of the Subsidiary Which Acquired
              the Security Being Reported on by the Parent Holding Company.

              Not applicable.

Item 8.       Identification and Classification of Members of the Group.

              Not applicable.

Item 9.       Notice of Dissolution of Group.

              Not applicable.

Item 10.      Certification.

              Not applicable. This Schedule 13G is not being filed pursuant to
              Rule 13d-1(b) or (c).


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 29264J 10 8  |           13G            |   Page  5  of   5  Pages  |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------


Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                                   /s/ Wallace G. Dempsey
                                                   ------------------------
January 31, 1999                                   Signature


                                                   Wallace G. Dempsey
                                                   ------------------------
                                                   Name







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