MAYFIELD VII
SC 13G, 1998-02-17
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<PAGE>   1
                               EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
             TO RULES 13d-1(b) AND (c) AND AMENDMENTS THERETO FILED
                              PURSUANT TO 13d-2(b)
                               (Amendment No.___)(1)


                              Megabios Corporation
                                (Name of Issuer)


                    Common Stock, par value $.001 per share
                         (Title of Class of Securities)


                                    58515T102
                                 (CUSIP Number)


(1)The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



<PAGE>   2
CUSIP NO. 58515T102                       13G           PAGE  2    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON                 
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          MAYFIELD VII, A CALIFORNIA LIMITED PARTNERSHIP
          94-3167809
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          CALIFORNIA
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,226,505
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,226,505
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,226,505          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          9.7%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          PN
          ---------------------------------------------------------------------





<PAGE>   3
CUSIP NO. 58515T102                       13G           PAGE  3    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON                 
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                
          MAYFIELD VII MANAGEMENT PARTNERS, A CALIFORNIA LIMITED PARTNERSHIP
          94-3167811
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          CALIFORNIA
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,226,505
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,226,505
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,226,505          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          9.7%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          PN
          ---------------------------------------------------------------------






<PAGE>   4
CUSIP NO. 58515T102                       13G           PAGE  4    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          MAYFIELD ASSOCIATES FUND II, A CALIFORNIA LIMITED PARTNERSHIP
          94-3191510
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          CALIFORNIA
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     61,163
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               61,163
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          61,163          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          0.4%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          PN
          ---------------------------------------------------------------------








<PAGE>   5
CUSIP NO. 58515T102                       13G           PAGE  5    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          YOGEN K. DALAL
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------


<PAGE>   6
CUSIP NO. 58515T102                       13G           PAGE  6    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          F. GIBSON MYERS, JR.
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------









<PAGE>   7
CUSIP NO. 58515T102                       13G           PAGE  7    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          KEVIN A. FONG
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------








<PAGE>   8
CUSIP NO. 58515T102                       13G           PAGE  8    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          WILLIAM D. UNGER
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------








<PAGE>   9
CUSIP NO. 58515T102                       13G           PAGE  9    OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          WENDELL G. VAN AUKEN 
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------

<PAGE>   10
CUSIP NO. 58515T102                       13G           PAGE  10   OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          MICHAEL J. LEVINTHAL
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------

<PAGE>   11
CUSIP NO. 58515T102                       13G           PAGE  11   OF  21  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          A. GRANT HEIDRICH, III
          SOCIAL SECURITY NUMBER: ###-##-####
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)   [   ]
                                                                    (b)   [ X ]

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          U.S.
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    -0-        
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     1,287,668
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   -0-
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               1,287,668
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          1,287,668          
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES                                                         [   ]
          
          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          10.1%         
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON
          IN
          ---------------------------------------------------------------------


<PAGE>   12
ITEM 1.

        (a)    NAME OF ISSUER:

               Megabios Corporation

        (b)    ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

               863 A Mitten Road
               Burlingame, CA 94010

ITEM 2.

        (a)    NAME OF PERSONS FILING:

               Mayfield VII, a California Limited Partnership
               Mayfield VII Management Partners, a California 
               Limited Partnership
               Mayfield Associates Fund II, a California Limited Partnership
               Yogen K. Dalal
               Kevin A. Fong
               Wendell G. Van Auken
               A. Grant Heidrich, III
               F. Gibson Myers, Jr.
               William D. Unger
               Michael J. Levinthal

        (b)    ADDRESS OF PRINCIPAL BUSINESS OFFICE:

               c/o The Mayfield Fund
               2800 Sand Hill Road
               Menlo Park, CA 94025

        (c)    CITIZENSHIP:

               The entities listed in Item 2(a) are California Liminted 
               Partnerships.
               The individuals listed in Item 2(a) are U.S. citizens.

        (d)    TITLE OF CLASS OF SECURITIES:

               Common Stock, par value $.001 per share.

        (e)    CUSIP NUMBER:

               58515T102


                              Page 12 of 21 pages.
<PAGE>   13

ITEM 3.  IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b),
         CHECK WHETHER THE PERSON FILING IS A:

         Not applicable

ITEM 4.  OWNERSHIP

         The information regarding ownership as set forth in Items 5-9 of Pages
         2-11 hereto, is hereby incorporated by reference.

         For a summary of total ownership by all Reporting Persons, see Exhibit
         2 hereto.

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

         If this statement is being filed to report the fact that as of the date
         hereof the reporting person has ceased to be the beneficial owner of
         more than five percent of the class of securities, check the following
         [].

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

         Not applicable.

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
         SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

         Not applicable.

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

         Not applicable.

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

         Not applicable.

ITEM 10. CERTIFICATION

         Not applicable.


                              Page 13 of 21 pages.
<PAGE>   14
                                   SIGNATURES


               After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

Date:  February 17, 1998
                            MAYFIELD VII
                            A California Limited Partnership

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Authorized Signatory

                            By: MAYFIELD VII MANAGEMENT PARTNERS
                            A California Limited Partnership

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Authorized Signatory

                            By: MAYFIELD ASSOCIATES FUND II
                            A California Limited Partnership

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Authorized Signatory

                            YOGEN K. DALAL

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact

                            F. GIBSON MYERS, JR.

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact

                            KEVIN A. FONG

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact

                            WILLIAM D. UNGER

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact



                              Page 14 of 21 pages.
<PAGE>   15
                            WENDELL G. VAN AUKEN

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact

                            MICHAEL J. LEVINTHAL

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact


                            A. GRANT HEIDRICH, III

                            By: /s/ George A. Pavlov
                               -----------------------------------------------
                               George A. Pavlov, Attorney In Fact


                              Page 15 of 21 pages.
<PAGE>   16
                                    EXHIBIT 1


         STATEMENT APPOINTING DESIGNATED FILER AND AUTHORIZED SIGNATORY


               Each of the undersigned entities and individuals (collectively,
the "Reporting Persons") hereby designates the entity listed in Column II of
SCHEDULE 1 hereto, or such other person or entity as is designated in writing by
George A. Pavlov (any such entity is referred to as the "Designated Filer") as
the beneficial owner to make filings of Schedules 13D and 13G (and any
amendments thereto) pursuant to Section 13(d) of the Securities Exchange Act of
1934 (the "Exchange Act") and of Forms 3, 4 and 5 (and any amendments thereto)
pursuant to Section 16(a) of the Exchange Act (collectively, the "Reports") with
respect to the securities of the entity listed in Column I of SCHEDULE 1 hereto
and with respect to the securities of any other entity whose securities are now,
or hereafter become, publicly traded and whose securities are beneficially owned
(directly or indirectly) both by such Reporting Person and by such Designated
Entity (collectively, the "Companies").

               Each Reporting Person hereby further authorizes and designates
GEORGE A. PAVLOV (the "Authorized Signatory") to execute and file on behalf of
such Reporting Person the Reports with respect to the securities of the
Companies, including all Schedules 13D and 13G and Forms 3, 4 and 5, and any
amendments thereto, that the Reporting Person may be required to file with the
United States Securities and Exchange Commission as a result of the Reporting
Person's ownership of, or transactions in securities of the Companies.

               The authority of the Designated Filer and the Authorized
Signatory under this document with respect to each Reporting Person shall
continue until such Reporting Person is no longer required to file Schedules 13D
or 13G or Forms 3, 4 and 5 with respect to the Reporting Person's ownership of,
or transactions in, the securities of the Companies, unless earlier revoked in
writing. Each Reporting Person acknowledges that the Designated Filer and the
Authorized Signatory are not assuming any of the Reporting Person's
responsibilities to comply with Section 13(d) of Section 16 of the Exchange Act.


                              Page 16 of 21 pages.
<PAGE>   17

Date:  February 17, 1998             MAYFIELD VII
                                     A California Limited Partnership

                                    By:     Mayfield VII Management Partners,
                                            a California Limited Partnership,
                                            Its General Partner

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                        George A. Pavlov, Authorized Signatory


Date:  February 17, 1998            MAYFIELD VII MANAGEMENT PARTNERS
                                    A California Limited Partnership

                                    By: /s/ George A. Pavlov
                                        -------------------------------------
                                       George A. Pavlov, Authorized Signatory


Date:  February 17, 1998            MAYFIELD ASSOCIATES FUND II
                                    A California Limited Partnership
                                    

                                    By: /s/ George A. Pavlov
                                        -------------------------------------
                                       George A. Pavlov, Authorized Signatory





                              Page 17 of 21 pages.
<PAGE>   18
Date:  February 17, 1998             YOGEN K. DALAL

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact

Date:  February 17, 1998             F. GIBSON MYERS, JR.

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact

Date:  February 17, 1998             KEVIN A. FONG

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact



                              Page 18 of 21 pages.
<PAGE>   19
Date:  February 17, 1998             WILLIAM D. UNGER

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact

Date:  February 17, 1998             WENDELL G. VAN AUKEN

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact

Date:  February 17, 1998             MICHAEL J. LEVINTHAL

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact


Date:  February 17, 1998             A. GRANT HEIDRICH, III

                                     By: /s/ George A. Pavlov
                                         -------------------------------------
                                         George A. Pavlov, Attorney In Fact



                              Page 19 of 21 pages.
<PAGE>   20
                                   SCHEDULE 1

<TABLE>
<CAPTION>
   PUBLICLY TRADED          DESIGNATED FILER           PERSONS/ENTITIES ON WHOSE BEHALF THE
       COMPANY                                               DESIGNATED FILER MAY ACT
- ----------------------    ----------------------    --------------------------------------------
<S>                       <C>                       <C>
Megabios Corporation      Mayfield VII              Mayfield VII Management Partners, Mayfield
                                                    Associates Fund II, Yogen K. Dalal, F.
                                                    Gibson Myers, Kevin A. Fong, William D.
                                                    Unger, Wendell G. Van Auken, Michael
                                                    J. Levinthal, A. Grant Heidrich, III
</TABLE>




                              Page 20 of 21 pages.
<PAGE>   21
                                    EXHIBIT 2

<TABLE>
<CAPTION>
                                                          PERCENT OF
                                                            CLASS
  NAME OF REPORTING PERSON       NUMBER OF SHARES        BENEFICIALLY
                                                           OWNED(1)
- -----------------------------    ------------------    -----------------
<S>                              <C>                   <C>
Mayfield VII,
a California Limited                  1,226,505 (2)               9.7%
Partnership

Mayfield VII Management
Partners, a California
Limited Partnership                   1,226,505 (2)               9.7%

Mayfield Associates Fund II, a          61,163 (3)               0.4%
California Limited
Partnership

Yogen K. Dalal                        1,287,668 (4)              10.1%

F. Gibson Myers, Jr.                  1,287,668 (4)              10.1%

Kevin A. Fong                         1,287,668 (4)              10.1%

William D. Unger                      1,287,668 (4)              10.1%

Wendell G. Van Auken                  1,287,668 (4)              10.1%

Michael J. Levinthal                  1,287,668 (4)              10.1%

A. Grant Heidrich, III                1,287,668 (4)              10.1%

Total                                 1,287,668 (4)              10.1%
</TABLE>

(1) The respective percentages set forth in this column were obtained by
dividing the number of shares by the aggregate number of outstanding shares of
Common Stock as of 12/31/97.

(2) Represents shares held of record by Mayfield VII, of which Mayfield VII
Management Partners is the sole General Partner.

(3) Represents shares held of record by Mayfield Associates Fund II.

(4) The individual Reporting Persons listed are General Partners of Mayfield
VII Management Partners, which is the General Partner of Mayfield VII. The
individual Reporting Persons are also General Partners of Mayfield Associates
Fund II. The individual Reporting Persons may be deemed to have shared voting
and dispositive power over the shares which are or may be deemed to be
beneficially owned by Mayfield VII Management Partners and Mayfield Associates
Fund II but disclaim such beneficial ownership. Each individual Reporting
Person expressly disclaims that he is the beneficial owner of any shares which
are held by any other individual Reporting Person in his individual capacity.
        



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