COCENSYS INC
DEF 14A, 1997-05-23
PHARMACEUTICAL PREPARATIONS
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                         COCENSYS, INC.
                      213 Technology Drive
                        Irvine, CA 92618



                                                     May 23, 1997

Dear Stockholder:

  On behalf of CoCensys, Inc. (the "Company"), I cordially invite you to 
attend the Annual Meeting of Stockholders, which will begin at 2:00 p.m. on 
Wednesday, June 25, 1997, at The Sutton Place Hotel, 4500 MacArthur 
Boulevard, Newport Beach, California.  At the meeting, stockholders will be 
asked (i) to elect two directors to hold office until the 2000 annual meeting 
of stockholders; (ii) to approve the Company's 1992 Non-Employee Directors' 
Stock Option Plan, as amended; (iii) to approve the Company's 1996 Equity 
Incentive Plan; and (iv) to ratify the selection of Ernst & Young LLP as the 
Company's independent auditors for the next fiscal year.  The accompanying 
Notice and Proxy Statement describe these proposals.  Also enclosed with 
these proxy materials are the Company's 1996 Annual Report and Quarterly 
Report on Form 10-Q for the quarter ended March 31, 1997.  We urge you to 
read this information carefully.

  The directors and officers of the Company hope that as many stockholders as 
possible will be present at the meeting.  Because the vote of each 
stockholder is important, we ask that you sign and return the enclosed proxy 
card in the envelope provided, whether or not you now plan to attend the 
meeting.  This will not limit your right to change your vote at the meeting 
or to attend the meeting.

  We appreciate your cooperation and interest in the Company.  To assist us 
in preparation for the meeting, please return your proxy card at your 
earliest convenience.

                                        Sincerely yours,


                                        /s/ Lowell E. Sears

                                        LOWELL E. SEARS
                                        Chairman of the Board

<PAGE>

                         COCENSYS, INC.
                      213 Technology Drive
                        Irvine, CA 92618

             NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                    TO BE HELD ON JUNE 25, 1997

TO THE STOCKHOLDERS OF COCENSYS, INC.:

NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of CoCensys, 
Inc., a Delaware corporation (the "Company"), will be held on Wednesday, June 
25, 1997, at 2:00 p.m., local time, at The Sutton Place Hotel, 4500 MacArthur 
Boulevard, Newport Beach, California for the following purposes:

1.   To elect two directors to hold office until the 2000 annual meeting of
     stockholders.

2.   To approve the amendment and restatement of the Company's 1992 
     Non-Employee Directors' Stock Option Plan to increase the annual option 
     grants thereunder, extend the term thereof and conform the administrative
     provisions thereof to the amended rules applicable under Section 16 of the
     Securities and Exchange Act of 1934, as amended.

3.   To approve the Company's 1996 Equity Incentive Plan and the issuance of
     2,800,000 shares of the Company's Common Stock thereunder.

4.   To ratify the selection of Ernst & Young LLP as independent auditors of 
     the Company for its fiscal year ending December 31, 1997.

5.   To transact such other business as may properly come before the meeting 
     or any adjournment thereof.

  The foregoing items of business are more fully described in the Proxy 
Statement accompanying this Notice.

  The Board of Directors has fixed the close of business on May 7, 1997, as 
the record date for the determination of stockholders entitled to notice of 
and to vote at this Annual Meeting and at any adjournment thereof.

                              By Order of the Board of Directors,

                              /s/ Alan C. Mendelson

                              Alan C. Mendelson
                              Secretary

Irvine, California
May 23, 1997


ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON. 
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN 
AND RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR 
REPRESENTATION AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID 
IF MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE.  EVEN IF YOU 
HAVE GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE 
MEETING. PLEASE NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A 
BROKER, BANK OR OTHER NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST 
OBTAIN FROM THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.

<PAGE>


                         COCENSYS, INC.
                      213 TECHNOLOGY DRIVE
                        IRVINE, CA 92618

                        PROXY STATEMENT
              FOR ANNUAL MEETING OF STOCKHOLDERS
                         JUNE 25, 1997

         INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

  The enclosed proxy is solicited on behalf of the Board of Directors of 
CoCensys, Inc., a Delaware corporation ("CoCensys" or the "Company"), for use 
at the Annual Meeting of Stockholders (the "Annual Meeting") to be held on 
June 25, 1997, at 2:00 p.m., local time, or at any adjournment or 
postponement thereof, for the purposes set forth herein and in the 
accompanying Notice of Annual Meeting.  The Annual Meeting will be held at 
The Sutton Place Hotel, 4500 MacArthur Boulevard, Newport Beach, California.  
The Company intends to mail this proxy statement and accompanying proxy card 
on or about May 23, 1997, to all stockholders entitled to vote at the Annual 
Meeting.

SOLICITATION

  The Company will bear the entire cost of solicitation of proxies including 
preparation, assembly, printing and mailing of this proxy statement, the 
proxy and any additional information furnished to stockholders.  Copies of 
solicita tion materials will be furnished to banks, brokerage houses, 
fiduciaries and custodians holding in their names shares of Common Stock 
beneficially owned by others to forward to such beneficial owners.  The 
Company may reimburse persons representing beneficial owners of Common Stock 
for their costs of forwarding solicitation materials to such beneficial 
owners.  Original solicitation of proxies by mail may be supplemented by 
telephone, telegram or personal solicitation by directors, officers or other 
regular employees of the Company. No additional compensation will be paid to 
directors, officers or other regular employees for such services.

VOTING RIGHTS AND OUTSTANDING SHARES

  Only holders of record of Common Stock at the close of business on May 7, 
1997, will be entitled to notice of and to vote at the Annual Meeting.  At 
the close of business on May 7, 1997, the Company had outstanding and 
entitled to vote 22,517,321 shares of Common Stock.  Each holder of record of 
Common Stock on such date will be entitled to one vote for each share held on 
all matters to be voted upon at the Annual Meeting.

  All votes will be tabulated by the inspector of election appointed for the 
meeting, who will separately tabulate affirmative and negative votes, 
abstentions and broker non-votes.  Abstentions will be counted toward the 
tabulation of votes cast on proposals presented to the stockholders and will 
have the same effect as negative votes.  Broker non-votes are counted toward 
a quorum, but are not counted for any purpose in determining whether a matter 
has been approved.

REVOCABILITY OF PROXIES

  Any person giving a proxy pursuant to this solicitation has the power to 
revoke it at any time before it is voted.  It may be revoked by filing with 
the Secretary of the Company, at the Company's principal executive office, 
213 Technology Drive, Irvine, California 92618, a written notice of 
revocation or a duly executed proxy bearing a later date, or it may be 
revoked by attending the meeting and voting in person.  Attendance at the 
meeting will not, by itself, revoke a proxy.

<PAGE>


STOCKHOLDER PROPOSALS

  Proposals of stockholders that are intended to be presented at the 
Company's 1998 annual meeting of stockholders must be received by the Company 
not later than January 23, 1998 in order to be included in the proxy 
statement relating to that meeting.

                           PROPOSAL 1

                     ELECTION OF DIRECTORS

  The Company's Restated Certificate of Incorporation and Bylaws provide that 
the Board of Directors shall be divided into three classes, each class 
consisting, as nearly as possible, of one-third of the total number of 
directors, with each class having a three-year term.  Vacancies on the Board 
may be filled by persons elected by either the holders of a majority of the 
voting power of the then outstanding shares of stock of the Company entitled 
to vote generally in the election of directors voting together as a class or 
by a majority of the remaining directors.  Newly created directorships 
resulting from any increase in the number of directors shall, unless the 
Board of Directors determines by resolution that any such newly-created 
directorship shall be filled by the stockholders, be filled only by a 
majority of the remaining directors.  A director elected by the Board to fill 
a vacancy created by an increase in the Board of Directors shall serve for 
the remainder of the full term of the class of directors in which the vacancy 
occurred and until such director's successor is elected and has qualified.

  The Board of Directors presently is composed of eight members.  There are 
two directors in the class whose term of office expires in 1997, each of whom 
is currently a director of the Company.  Timothy J. Rink, M.D. was previously 
elected by the stockholders; F. Richard Nichol, Ph.D. was elected by the 
Board of Directors.  If elected at the Annual Meeting, each of the nominees 
would serve until the 2000 annual meeting and until his successor is elected 
and has qualified, or until such director's earlier death, resignation or 
removal.

  Directors are elected by a plurality of the votes present in person or 
represented by proxy and entitled to vote at the meeting.  Shares represented 
by executed proxies will be voted, if authority to do so is not withheld, for 
the election of the two nominees named below.  In the event that any nominee 
should be unavailable for election as a result of an unexpected occurrence, 
such shares will be voted for the election of such substitute nominee as 
management may propose.  Each person nominated for election has agreed to 
serve if elected, and management has no reason to believe that any nominee 
will be unable to serve.

  Set forth below is biographical information for each person nominated and 
each person whose term of office as a director will continue after the Annual 
Meeting.

NOMINEES FOR ELECTION FOR THREE-YEAR TERMS EXPIRING AT THE 2000 ANNUAL MEETING

CLASS II DIRECTORS

F. RICHARD NICHOL, Ph.D.

  Dr. Nichol, 55, joined the Company as its President, Chief Executive 
Officer and a Director in January 1997.  From October 1995 until joining 
CoCensys, Dr. Nichol was a consultant providing clinical research and 
clinical data management expertise to biopharmaceutical and pharmaceutical 
organizations through his firm, Nichol Clinical Technologies Corporation.  
From 1975 until October 1995, he was President and Chief Executive Officer of 
IBRD, Inc., which has since become IBRD - Rostrum Global, Inc., a clinical 
research organization. Dr. Nichol served as a Senior Research Scientist 
specializing in virology at the Upjohn Company from 1967 until 1975.  Dr. 
Nichol is a director of G Recordings.  He earned his B.S. in Science; his 
M.S. in Microbiology/Biophysics; and his Ph.D. in Microbiology from 
Pennsylvania State University. 

                                        2.

<PAGE>

TIMOTHY J. RINK, M.D.

  Dr. Rink, 50, has served as a director of the Company since August 1990. 
Dr. Rink is Chairman of the Board of Directors, Chief Executive Officer and 
President of Aurora Biosciences Corporation.  From February 1990 until 
November 1995, he served as President, Chief Technical Officer and as a 
director of Amylin Pharmaceuticals, Inc., a pharmaceutical company.  From 
1984 to January 1990, he served as Vice President, Research (U.K.) for 
SmithKline Beecham, plc. and from 1988 to February 1990, he was a founding 
member of the Emerging Technologies Committee of the Prime Minister's 
Advisory Council on Science and Technology in the United Kingdom.  Dr. Rink 
is currently a director of NPS Pharmaceuticals, Inc.  He received his M.D. 
and Sc.D. degrees from the University of Cambridge.

DIRECTORS CONTINUING IN OFFICE UNTIL THE 1998 ANNUAL MEETING

CLASS III DIRECTORS

KELVIN W. GEE, Ph.D.

  Dr. Gee, 44, co-founded CoCensys in February 1989 and has been a director 
since that time.  He also served as Chairman of the Board of the Company from 
inception until October 1991.  He has served as the Company's Chief 
Scientific Officer on a consulting basis since October 1991.  Since July 
1996, Dr. Gee has been a Professor of Pharmacology at the University of 
California, Irvine, College of Medicine.  From January 1992 to July 1996, Dr. 
Gee was an Associate Professor of Pharmacology at the same institution.  From 
July 1985 to January 1992, Dr. Gee was an Assistant and then Associate 
Professor of Pharmacology at the University of Southern California.  Dr. Gee 
received his Ph.D. in Pharmacology and Toxicology from the University of 
California, Davis in 1981.

ROBERT G. McNEIL, Ph.D.

  Dr. McNeil, 53, co-founded the Company in February 1989.  He served as 
Chief Executive Officer of the Company until October 1991 and as Chairman of 
the Board from October 1991 until June 1995.  Dr. McNeil has been a general 
partner of Sanderling Ventures, a venture capital management company, since 
1979.  In conjunction with his activities at Sanderling Ventures, Dr. McNeil 
has served as President and Chief Executive Officer of several biomedical 
companies. Currently, he serves on the Board of Directors of several private 
corporations. Dr. McNeil received a Ph.D. in Molecular Biology, Biochemistry 
and Genetics from the University of California, Irvine in 1972.

LOWELL E. SEARS

  Mr. Sears, 46, has served as a director of the Company since November 1994 
and as Chairman of the Board since June 1995.  He is the Chairman and Chief 
Executive Officer of Sears Capital Management, Inc., a private holding and 
investment company.  From 1988 to April 1994, he was Chief Financial Officer 
of Amgen Inc., a biotechnology company.  In addition to his role as Chief 
Financial Officer of Amgen, Mr. Sears served from 1992 to 1994 as Senior Vice 
President, responsible for the Asia-Pacific region.  In this role, he 
established development, marketing and sales capabilities in a number of 
countries, including Japan and the People's Republic of China.  He also 
served as Chief Executive Officer for the joint venture Kirin-Amgen Inc.  Mr. 
Sears is director of Techne Corporation, Neose Technologies, Inc. and 
Activated Cell Therapy, Inc.  Mr. Sears holds a B.A. in Economics from 
Claremont McKenna College and an M.B.A. from Stanford University.


                                        3.

<PAGE>

DIRECTORS CONTINUING IN OFFICE UNTIL THE 1999 ANNUAL MEETING

CLASS I DIRECTORS

JAMES C. BLAIR, Ph.D.

  Dr. Blair, 57, has served as a director of the Company since August 1990.  
He has been a general partner of Domain Associates, a venture capital 
management company, since July 1985.  Dr. Blair is a director of Amylin 
Pharmaceuticals, Inc. and Dura Pharmaceuticals, Inc., Vice Chairman of the 
Board of Directors of Gensia, Inc. and Chairman of the Board of Directors of 
Houghten Pharmaceuticals.  Dr. Blair holds a B.S.E. in Electrical Engineering 
from Princeton University and M.S.E. and Ph.D. degrees in Electrical 
Engineering from the University of Pennsylvania.

ALAN C. MENDELSON

  Mr. Mendelson, 49, has served as Secretary of the Company since July 1990 
and as a director since April 1994.  He has been a partner of Cooley Godward 
LLP, a private law firm and counsel to the Company, since 1980, and served as 
managing partner of its Palo Alto office from May 1990 through March 1995 and 
from November 1996 to the present.  Mr. Mendelson also served as Acting 
General Counsel of Cadence Design Systems, Inc., an electronic design 
automation software company, from November 1995 to June 1996.  Mr. Mendelson 
is currently a director of Acuson Corporation, Isis Pharmaceuticals, Inc. and 
Elexsys International, Inc.  Mr. Mendelson received his J.D. from Harvard 
University in 1973.

ECKARD WEBER, M.D.

  Dr. Weber, 47, was elected to the Board of Directors of CoCensys in June 
1994 pursuant to the terms of the agreement governing the Company's 
acquisition of Acea Pharmaceuticals, Inc.  He has been the Company's Senior 
Vice President, Research and Drug Discovery, since November 1995.  He has 
been a Professor of Pharmacology at the University of California, Irvine 
since 1989.  Dr. Weber received his Doctor of Medicine degree from the 
University of Ulm School of Medicine, West Germany.  He also completed his 
internship at the University Hospital, University of Ulm School of Medicine.

               THE BOARD OF DIRECTORS RECOMMENDS
             A VOTE IN FAVOR OF EACH NAMED NOMINEE.


BOARD COMMITTEES AND MEETINGS

  During the fiscal year ended December 31, 1996, the Board of Directors held 
nine meetings.  The Board has standing Audit, Compensation and Nominating 
Committees.

  The Audit Committee meets with the Company's independent auditors at least 
annually to review the results of the annual audit and discuss the financial 
statements; recommends to the Board whether the independent auditors should 
be retained; and receives and considers the auditors' comments as to 
controls, adequacy of staff and management performance and procedures in 
connection with audit and financial controls.  The Audit Committee, which is 
currently composed of two non-employee directors, Messrs. Sears and 
Mendelson, met twice during the fiscal year ended December 31, 1996.

                                        4.

<PAGE>

  The Compensation Committee sets the Company's compensation policies, 
evaluates the performance and determines the compensation of executive 
officers and performs such other functions regarding compensation as the 
Board may delegate.  The Compensation Committee met twice during the fiscal 
year ended December 31, 1996.  It is currently composed of four non-employee 
directors: Drs. Blair, McNeil and Rink and Mr. Sears.  A Non-Officer Stock 
Option Administration Committee, currently composed of Dr. Nichol, was 
established in August 1995.  Such Committee is authorized to make stock 
option grants covering up to 8,000 shares each under the 1990 Stock Option 
Plan to certain non-officer employees of the Company.  Such Committee acted 
17 times during fiscal 1996.

  The Nominating Committee interviews, evaluates, nominates and recommends 
individuals for membership on the Board and committees thereof and nominates 
specific individuals to be elected as officers of the Company by the Board.  
No procedure has been established for the consideration of nominees 
recommended by stockholders.  The Nominating Committee is currently composed 
of four non-employee directors:  Drs. Blair and McNeil and Messrs. Mendelson 
and Sears.  It did not meet during the fiscal year ended December 31, 1996.

  During the fiscal year ended December 31, 1996, each Board member attended 
75 percent or more of the aggregate of the meetings of the Board and of the 
committees on which he served that were held during the period for which he 
was a director or committee member, respectively.

                           PROPOSAL 2

            APPROVAL OF AMENDMENT AND RESTATEMENT OF
         1992 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

  In December 1992, the Board of Directors adopted, and the stockholders 
subsequently approved, the Company's 1992 Non-Employee Directors' Stock 
Option Plan (the "Directors' Plan").  As amended to date, the Directors' Plan 
provides for automatic, non-discretionary grants of options to purchase an 
aggregate of 350,000 shares of Common Stock.  The Board adopted the 
Directors' Plan in an effort to retain the services of persons serving as 
non-employee directors of the Company, to secure and retain the services of 
persons capable of serving such capacity, and to provide incentives for such 
persons to exert maximum efforts on behalf of the Company.

  In December 1996, the Board amended the Directors' Plan to conform the 
administrative provisions to the amended rules under Section 16 of the 
Securities Exchange Act of 1934, as amended (the "Exchange Act") to provide 
additional administrative flexibility.  In February 1997, the Board adopted 
additional amendments to the Directors' Plan, subject to stockholder 
approval, to increase the annual option grants thereunder from 4,000 shares 
(8,000 shares in the case of the Chairman of the Board) to 8,000 (12,000 in 
the case of the Chairman of the Board) and to extend the plan until December 
31, 1999.  The Board adopted the amendments to ensure compensation of 
non-employee directors at levels deemed appropriate by the Board.

  Stockholders are requested in this Proposal 2 to approve the Directors' 
Plan, as amended and restated.  The affirmative vote of the holders of a 
majority of the shares present in person or represented by proxy at the 
meeting and entitled to vote will be required to approve the Directors' Plan.

               THE BOARD OF DIRECTORS RECOMMENDS
                 A VOTE IN FAVOR OF PROPOSAL 2.

  The essential features of the Directors' Plan are outlined below.

GENERAL

  The Directors' Plan provides for non-discretionary grants of nonstatutory 
stock options.  Nonstatutory stock options granted under the Directors' Plan 
are intended not to qualify as "incentive stock options" under the Internal 
Revenue Code of 1986, as amended (the "Code").  See "Federal Income Tax 
Information" for a discussion of the tax treatment of nonstatutory stock 
options.

                                        5.

<PAGE>

PURPOSE

  The Directors' Plan was adopted to provide a means by which each 
director who is not otherwise an employee of the Company will be given an 
opportunity to purchase stock of the Company and to advance the interests of 
the Company through the motivation, attraction and retention of qualified 
non-employee directors.

ADMINISTRATION

  The Directors' Plan is administered by the Board of Directors.  The Board 
has the power to construe and interpret the Directors' Plan and is authorized 
to delegate administration of such plan to a committee composed of one or 
more members of the Board.  Such administration has been delegated to the 
Compensation Committee, which has the powers to administer the Plan that were 
originally possessed by the Board, subject to such limitations as the Board 
provides.  As used herein with respect to the Directors' Plan, the "Board" 
refers to the Compensation Committee as well as to the Board of Directors 
itself.

ELIGIBILITY

  Only non-employee directors of the Company are eligible to receive options 
under the Directors' Plan.  As of April 30, 1997, the Company's five 
non-employee directors were eligible to participate in the Directors' Plan.

STOCK SUBJECT TO THE DIRECTORS' PLAN

  If options granted under the Directors' Plan expire or otherwise terminate 
without having been exercised in full, the stock not purchased pursuant to 
such options again becomes available for issuance under the plan.

TERMS OF OPTIONS

  The following is a description of the terms of options under the Directors' 
Plan.

  NON-DISCRETIONARY GRANTS.  Option grants under the Directors' Plan are 
automatic and non-discretionary.  The Directors' Plan provides for the grant 
of an option to purchase 20,000 shares (40,000 shares in the case of the 
Chairman of the Board) to each person who was a non-employee director on the 
plan's adoption date or who is elected for the first time to be a 
non-employee director thereafter.  Additionally, on January 2nd of each year, 
each non-employee director will receive an option to purchase 8,000 shares 
(12,000 shares for the Chairman of the Board) of Common Stock of the Company.

  OPTION EXERCISE.  Except for annual option grants, options under the 
Directors' Plan vest in five equal installments over a period of five years 
commencing one year from the date of grant.  Annual grants vest in full one 
year from the date of grant.  Vesting of all options is subject to the 
requirement that the optionee has continuously served as a non-employee 
director or employee of or consultant to the Company, and attended at least 
75 percent of the Board meetings and the committee meetings of which he is a 
member.

  EXERCISE PRICE; PAYMENT.  The exercise price of options granted under the 
Directors' Plan is 100 percent of the fair market value of the Common Stock 
of the Company on the date on which the option is granted, except that 
options granted on the date the Directors' Plan was adopted by the Board have 
an exercise price of $5.00 per share, which amount is greater than 110 
percent of the fair market value of the Common Stock of the Company on such 
date.  The exercise price of options granted under the Directors' Plan must 
be paid either (i) in cash at the time the option is exercised; (ii) by 
delivery of other common stock of the Company; or (iii) by a combination of 
the methods of payment specified in (i) or (ii) above.  On May 19, 1997, the 
closing price of the Company's Common Stock as reported on the Nasdaq 
National Market was $4.06 per share.

  TERM.  The maximum term of options under the Directors' Plan is 10 years 
from the date of grant.  Options under the Directors' Plan terminate three 
months after termination of the optionee's service as a non-employee director 
of the Company unless such termination of service is due to the optionee's 
death, in which case the option 

                                        6.

<PAGE>

shall terminate 12 months following the date of the optionee's death.  In all 
cases, an option may be exercised following termination of the optionee's 
service only for that number of shares for which it was exercisable on the 
date of termination of such services.

ADJUSTMENT PROVISIONS

  If there is any change in the stock subject to the Directors' Plan or 
subject to any option granted thereunder (through merger, consolidation, 
reorganization, recapitalization, stock dividend, dividend in property other 
than cash, stock split, liquidating dividend, combination of shares, exchange 
of shares, change in corporate structure or otherwise), the Directors' Plan 
and options outstanding thereunder will be appropriately adjusted as to the 
class and the maximum number of shares subject to such plan and to the class, 
number of shares and price per share of stock subject to such outstanding 
options.

EFFECT OF CERTAIN CORPORATE EVENTS

  The Directors' Plan provides that, in the event of a merger or 
consolidation in which the Company is not the surviving corporation, a 
reverse merger in which the Company's common stock is converted into other 
property or any other capital reorganization involving a change in control of 
the Company, then the time during which such options may be exercised will be 
accelerated and the options terminated if not exercised prior to such event.  
The acceleration of an award in the event of an acquisition or similar 
corporate event may be viewed as an anti-takeover provision, which may have 
the effect of discouraging a proposal to acquire or otherwise obtain control 
of the Company.

DURATION, AMENDMENT AND TERMINATION

  Unless sooner terminated, the Directors' Plan will terminate on December 
31, 1999, or upon the occurrence of any event described in the preceding 
paragraph.  The Board may suspend or terminate the Directors' Plan without 
stockholder approval or ratification at any time or from time to time.

  The Board may amend the Directors' Plan at any time or from time to time, 
provided that no amendment will be effective unless approved by the 
stockholders of the Company within 12 months before or after the adoption of 
the amendment, where the amendment would: (i) modify the requirements as to 
eligibility for participation to the extent such modification requires 
stockholder approval in order for such Plan to comply with the requirements 
of Rule 16b-3 of the Exchange Act ("Rule 16b-3"); (ii) increase the number of 
shares which may be issued under the plan or (iii) change any other provision 
of the Directors' Plan in any other way if such modification requires 
stockholder approval in order to comply with Rule 16b-3.

RESTRICTIONS ON TRANSFER

  Under the Directors' Plan, an option may not be transferred by the optionee 
otherwise than by will, by laws of descent and distribution or by a domestic 
relations order satisfying the requirements of Rule 16b-3.  During the 
lifetime of an optionee, an option may be exercised only by the optionee or 
by his guardian or legal representative.

FEDERAL INCOME TAX INFORMATION

  There normally are no tax consequences to the optionee or the Company by 
reason of the grant of nonstatutory stock options under the Directors' Plan.

  Upon the exercise of an option, the difference between the market value of 
the Common Stock on the date of exercise and the option price would be 
taxable to the non-employee director as ordinary income.  Subject to the 
requirement of reasonableness and the satisfaction of a tax reporting 
obligation, this amount will be deductible by the Company in the form of a 
business expense deduction.

                                        7.

<PAGE>


  Upon disposition of stock acquired upon exercise of a nonstatutory stock 
option, the optionee will recognize a capital gain or loss in an amount equal 
to the difference between the selling price and the sum of the amount paid 
for such shares plus any amount recognized as ordinary income by reason of 
the exercise of the option.  Such gain or loss will be long or short-term 
depending on whether the stock was held for more than one year from the date 
on which ordinary income was measured.  There are no tax consequences to the 
Company by reason of the disposition by the optionee of Common Stock acquired 
upon exercise of a nonstatutory stock option.

  In the event that there is a change in control of the Company, payments 
received by certain optionees that are contingent upon the change in control 
may constitute "parachute payments." If, by reason of such change in control, 
the exercisability of outstanding options is accelerated, the value of the 
acceleration is added to other contingent payments, if any, in determining 
whether the optionee has received "excess parachute payments."  In general, 
if an optionee receives excess parachute payments, an excise tax equal to 20 
percent of the amount of parachute payments is imposed on the optionee, and 
the Company does not receive a deduction for such amount.

NEW PLAN BENEFITS - 1992 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

  The following table presents information with respect to options granted 
under the Directors' Plan, as amended, which are subject to stockholder 
approval to the persons and groups indicated (no other individuals or groups 
are eligible to receive options under the Directors' Plan):

<TABLE>
<CAPTION>

                                                                      Number of Shares
        Name and Position                       Dollar Value ($)(1)   Subject to Options 
        -----------------                       ------------------   -------------------
<S>                                             <C>                  <C>
Lowell E. Sears, Chairman of the Board               60,000            12,000(2)
Alan C. Mendelson, Director                          40,000             8,000(2)
James C. Blair, Ph.D., Director                      40,000             8,000(2)
Robert G. McNeil, Ph.D., Director                    40,000             8,000(2)
Timothy J. Rink, M.D., Director                      40,000             8,000(2)
All Non-Employee Directors as a Group               220,000            44,000

</TABLE>

- ------------------

(1)  Aggregate exercise price of options.
(2)  4,000 shares subject to stockholder approval.

                                        8.

<PAGE>



                           PROPOSAL 3

      APPROVAL OF THE COMPANY'S 1996 EQUITY INCENTIVE PLAN


  In December 1996, the Board of Directors adopted, subject to stockholder 
approval, the CoCensys, Inc. 1996 Equity Incentive Plan (the "Equity Plan"), 
and authorized and reserved 2,800,000 shares of the Company's Common Stock 
for issuance under the Equity Plan.  The Equity Plan provides for the grant 
of incentive and nonstatutory stock options, stock appreciation rights, 
rights to purchase restricted stock and stock bonuses. The Board adopted the 
Equity Plan as a means to retain the services of persons who are now 
employees and directors of and consultants to the Company, to secure and 
retain the services of new employees, directors and consultants, and to 
provide incentives for such persons to exert maximum efforts on behalf of the 
Company.  As of May 19, 1997, options to purchase 1,034,504 shares of Common 
Stock were outstanding under the Equity Plan.

  Stockholders are requested in this Proposal 3 to approve the Equity Plan. 
The affirmative vote of the holders of a majority of the shares present in 
person or represented by proxy and entitled to vote at the meeting will be 
required to approve the Equity Plan.

               THE BOARD OF DIRECTORS RECOMMENDS
                 A VOTE IN FAVOR OF PROPOSAL 3.

  The essential features of the Equity Plan are outlined below.

GENERAL

  The Equity Plan provides for the grant of incentive stock options ("ISOs"), 
nonstatutory stock options ("NSOs"), stock appreciation rights ("SARs"), 
rights to purchase restricted stock and stock bonuses.  To date only ISOs and 
NSOs have been awarded under the Equity Plan.  ISOs granted under the Equity 
Plan are intended to qualify as "incentive stock options" within the meaning 
of Section 422 of the Code.  NSOs granted under the Equity Plan are intended 
not to qualify as incentive stock options under the Code.  See "Federal 
Income Tax Information" for a discussion of the tax treatment of the various 
awards included in the Equity Plan.

PURPOSE

  The Equity Plan was adopted to provide a means by which employees 
(including officers) and directors of and consultants to the Company may be 
given an opportunity to benefit from increases in the value of the stock of 
the Company, to secure and retain the services of persons holding or capable 
of filling such positions and to provide incentives for such persons to exert 
maximum efforts on behalf of the Company.

ADMINISTRATION

  The Equity Plan is administered by the Board.  The Board has the power to 
construe and interpret the Equity Plan and, subject to the provisions of the 
Equity Plan, to determine the persons to whom and the dates on which awards 
will be granted, what type of award will be granted, the number of shares to 
be subject to each award, the time or times during the term of each award 
within which all or a portion of such award may be exercised, the exercise 
price, the type of consideration and other terms of the award.  The Board is 
authorized to delegate administration of the Equity Plan to a committee or 
committees composed of one or more members of the Board and has delegated 
such administration to the Compensation Committee.  The Compensation 
Committee has the powers to administer the Equity Plan which were originally 
possessed by the Board, subject to such limitations as the Board provides.  
As used herein with respect to the Equity Plan, the "Board" refers to the 
Compensation Committee as well as to the Board of Directors.

                                        9.

<PAGE>


  In order to maximize the Company's ability to recognize a business expense 
deduction under Section 162(m) of the Code in connection with compensation 
recognized by "covered employees" (defined in Section 162(m) as the chief 
executive officer and other four most highly compensated officers), the 
regulations under Section 162(m) require that the directors who serve as 
members of the committee responsible for administering the Equity Plan with 
respect to these covered employees must be "outside directors."  The Equity 
Plan provides that in the discretion of the Board, a committee may consist 
solely of two (2) or more "outside directors," in accordance with Code 
Section 162(m), or solely of two (2) or more "non-employee directors," in 
accordance with Rule 16b-3.

ELIGIBILITY

  ISOs may be granted under the Equity Plan to employees (including officers) 
of the Company and any affiliates.  Employees (including officers), directors 
and consultants are eligible to receive awards other than ISOs under the 
Equity Plan.  As of April 30, 1997, all of the Company's 187 employees, 
directors and consultants were eligible to participate in the Equity Plan.

  No ISO may be granted under the Equity Plan to any person who, at the time 
of the grant, owns (or is deemed to own) stock possessing more than 10 
percent of the total combined voting power of the Company or any affiliate of 
the Company, unless the option exercise price is at least 110 percent of the 
fair market value of the stock subject to the option on the date of grant, 
and the term of the option does not exceed five years from the date of grant. 
 For ISOs granted under the Equity Plan, the aggregate fair market value, 
determined at the time of grant, of the shares of Common Stock with respect 
to which such options are exercisable for the first time by an optionee 
during any calendar year (under all such plans of the Company and its 
affiliates) may not exceed $100,000.

  The Company has included in the Equity Plan a per-employee limitation of 
500,000 shares of Common Stock subject to stock options and stock 
appreciation rights which may be granted during a 12-month period.  The 
purpose of including this limitation is to ensure that the Company generally 
will be able to deduct for tax purposes the compensation attributable to the 
exercise of options granted under the Equity Plan.

STOCK SUBJECT TO THE PLAN

  If awards granted under the Equity Plan expire or otherwise terminate 
without being exercised, the Common Stock not purchased pursuant to such 
awards again becomes available for issuance under the Equity Plan.

TERMS OF OPTIONS

  The following is a description of the permissible terms of options under 
the Equity Plan.  Individual option grants may be more restrictive as to any 
or all of the permissible terms described below.

  EXERCISE PRICE; PAYMENT.  The exercise price of ISOs under the Equity Plan 
may not be less than the fair market value of the Common Stock subject to the 
option on the date of the option grant, and in some cases (see "Eligibility" 
above), may not be less than 110 percent of such fair market value.  The 
exercise price of NSOs under the Equity Plan may not be less than 85 percent 
of the fair market value of Common Stock subject to the option on the date of 
the option grant.  However, with respect to any options granted with exercise 
prices below fair market value to covered employees, deductions for 
compensation attributable to the exercise of such options could be limited by 
Section 162(m).  See "Federal Income Tax Information."

  In the event of a decline in the value of the Company's Common Stock, the 
Board has the authority to offer employees the opportunity to replace 
outstanding higher priced options, whether incentive or nonstatutory, with 
new, lower priced options.  To the extent required by Section 162(m), an 
option repriced under the Equity Plan is deemed to be canceled and a new 
option granted.  Both the option deemed to be canceled and the new option 
deemed to be granted will be counted against the 500,000 per person share 
limitation.

  The exercise price of options granted under the Equity Plan must be paid 
either: (a) in cash at the time the option is exercised; or (b) at the 
discretion of the Board, (i) by delivery of other Common Stock of the 
Company, 


                                        10.

<PAGE>

(ii) pursuant to a deferred payment arrangement; or (iii) in any other form 
of legal consideration acceptable to the Board.

  OPTION EXERCISE.  Options granted under the Equity Plan may become 
exercisable ("vest") in cumulative increments as determined by the Board. 
Shares covered by currently outstanding options under the Equity Plan 
typically vest at the rate of 25 percent after one year and 1/48th per month 
thereafter during the optionee's employment or service as a consultant.  
Shares covered by options granted in the future under the Equity Plan may be 
subject to different vesting terms.  The Board has the power to accelerate 
the time during which an option may be exercised.  In addition, options 
granted under the Equity Plan may permit exercise prior to vesting, but in 
such event the optionee may be required to enter into an early exercise stock 
purchase agreement that allows the Company to repurchase shares not yet 
vested at their exercise price should the optionee leave the employ of the 
Company before vesting.  The Board has the power to include as part of any 
option agreement under the Equity Plan a re-load option, entitling the 
optionee to a further option (the "Reload Option") in the event the optionee 
exercises an option by surrendering other shares of Common Stock of the 
Company in accordance with the Equity Plan.  Such Reload Options shall be for 
a number of shares equal to the number of shares surrendered as part or all 
of the exercise price, shall have the same expiration date as that of the 
option exercised and an exercise price which is equal to 100 percent of the 
fair market value of the Common Stock on the date of exercise (except that 
any Reload Option which is an ISO shall have an exercise price equal to 110 
percent of the fair market value of the Common Stock on the date of exercise 
and a maximum term of five years).  Any such Reload Option may be an ISO or 
NSO, as the Board may designate at the time of the grant of the original 
option under the Equity Plan.

  TERM.  The maximum term of stock options under the Equity Plan is 10 years, 
except that in certain cases (see "Eligibility") the maximum term is five 
years.  Options under the Equity Plan terminate three months after 
termination of the optionee's employment or relationship as a consultant or 
director of the Company or any affiliate of the Company, unless (a) such 
termination is due to such person's permanent and total disability (as 
defined in the Code), in which case the option may, but need not, provide 
that it may be exercised at any time within one year of such termination; (b) 
the optionee dies while serving, or within in a three-month period of having 
served, the Company or any affiliate of the Company, in which case the option 
may, but need not, be exercisable (to the extent that the option was 
exercisable at the time of the optionee's death) within 12 months of the 
optionee's death by the person or persons to whom the rights to such option 
pass by will or by the laws of descent and distribution; or (c) the option by 
its terms specifically provides otherwise.  Individual options by their terms 
may provide for exercise within a longer period of time following termination 
of employment or the consulting relationship.

TERMS OF STOCK BONUSES AND PURCHASES OF RESTRICTED STOCK

  PURCHASE PRICE; PAYMENT.  The purchase price under each stock purchase 
agreement will be determined by the Board, but in no event shall the purchase 
price be less than 85 percent of the stock's fair market value on the date 
such award is made.  The purchase price of stock pursuant to a stock purchase 
agreement must be paid either: (i) in cash at the time of purchase; (ii) at 
the discretion of the Board, according to a deferred payment or other 
arrangement with the person to whom the Common Stock is sold; or (iii) in any 
other form of legal consideration that may be acceptable to the Board in its 
discretion. Eligible participants may be awarded stock pursuant to a stock 
bonus agreement in consideration of past services actually rendered to the 
Company or for its benefit.

  REPURCHASE.  Shares of the Common Stock sold or awarded under the Equity 
Plan may, but need not, be subject to a repurchase option in favor of the 
Company in accordance with a vesting schedule determined by the Board.  In 
the event a person ceases to be an employee of or ceases to serve as a 
director of or consultant to the Company or an affiliate of the Company, the 
Company may repurchase or otherwise reacquire any or all of the shares of the 
bonus or restricted stock held by that person that have not vested as of the 
date of termination under the terms of the stock bonus or restricted stock 
purchase agreement between the Company and such person.

                                        11.

<PAGE>


STOCK APPRECIATION RIGHTS

  The Equity Plan authorizes three types of SARs.

  TANDEM STOCK APPRECIATION RIGHTS.  Tandem SARs are tied to an underlying 
option and require the holder to elect whether to exercise the underlying 
option or to surrender the option for an appreciation distribution equal to 
the market price of the vested shares purchasable under the surrendered 
option less the aggregate exercise price payable for such shares.  
Appreciation distributions payable upon exercise of tandem stock appreciation 
rights must be made in cash.

  CONCURRENT STOCK APPRECIATION RIGHTS.  Concurrent SARs are tied to an 
underlying option and are exercised automatically at the same time the 
underlying option is exercised.  The holder receives an appreciation 
distribution equal to the market price of the vested shares purchased under 
the option less the aggregate exercise price payable for such shares.  
Appreciation distributions payable upon exercise of concurrent stock 
appreciation rights must be made in cash.

  INDEPENDENT STOCK APPRECIATION RIGHTS.  Independent SARs are granted 
independently of any option and entitle the holder to receive upon exercise 
an appreciation distribution equal to the fair market value on the date of 
exercise of a number of shares equal to the number of share equivalents to 
which the holder is vested under the independent stock appreciation right 
less the fair market value of such number of shares of stock on the date of 
grant. Appreciation distributions payable upon exercise of independent stock 
appreciation rights may, at the Board's discretion, be made in cash, in 
shares of the Common Stock or a combination thereof.

ADJUSTMENT PROVISIONS

  If there is any change in the stock subject to the Equity Plan or subject 
to any award granted under the Equity Plan (through merger, consolidation, 
reorganization, recapitalization, stock dividend, dividend in property other 
than cash, stock split, liquidating dividend, combination of shares, exchange 
of shares, change in corporate structure or otherwise), the Equity Plan and 
awards outstanding thereunder will be appropriately adjusted as to the type 
of security and the maximum number of shares subject to such plan, the 
maximum number of shares which may be granted to an employee during any 
calendar year, and the type of security, number of shares and price per share 
of stock subject to such outstanding awards.

EFFECT OF CERTAIN CORPORATE EVENTS

  The Equity Plan provides that, in the event of a dissolution or liquidation 
of the Company, specified type of merger or other corporate reorganization, 
to the extent permitted by law, any surviving corporation will be required to 
either assume awards outstanding under the Equity Plan or substitute similar 
awards for those outstanding under the Equity Plan, or such outstanding 
awards will continue in full force and effect.  In the event that any 
surviving corporation declines to assume or continue awards outstanding under 
the Equity Plan, or to substitute similar awards, then the time during which 
such awards may be exercised will be accelerated and the awards terminated if 
not exercised during such time.  The acceleration of an award in the event of 
an acquisition or similar corporate event may be viewed as an anti-takeover 
provision, which may have the effect of discouraging a proposal to acquire or 
otherwise obtain control of the Company.

DURATION, AMENDMENT AND TERMINATION

  The Board may suspend or terminate the Equity Plan without stockholder 
approval or ratification at any time or from time to time.  Unless sooner 
terminated, the Equity Plan will terminate on December 16, 2006.

  The Board may also amend the Equity Plan at any time or from time to time. 
However, no amendment will be effective unless approved by the stockholders 
of the Company, to the extent stockholder approval is necessary in order for 
the Plan to satisfy Section 422 of the Code, if applicable, Rule 16b-3 or 
Nasdaq or other securities exchange listing requirements.  The Board may 
submit any other amendment to the Equity Plan for 


                                        12.

<PAGE>

stockholder approval, including, but not limited to, amendments intended to 
satisfy the requirements of Section 162(m) of the Code regarding the 
exclusion of performance-based compensation from the limitation on the 
deductibility of compensation paid to certain employees.

RESTRICTIONS ON TRANSFER

  Under the Equity Plan, ISOs may not be transferred by the optionee 
otherwise than by will or by the laws of descent and distribution and, during 
the lifetime of the optionee, may be exercised only by the optionee. 
Independent SARs and NSOs may not be transferred except by express provision 
of the applicable agreement, by will or by the laws of descent and 
distribution or pursuant to a domestic relations order satisfying the 
requirements of Rule 16b-3 and, during the lifetime of the optionee, may be 
exercised only by the optionee or a transferee pursuant to a domestic 
relations order.  No rights under a stock bonus or restricted stock purchase 
agreement are transferable except by will or the laws of descent and 
distribution or, if the agreement so provides, pursuant to a domestic 
relations order.  A tandem SAR or concurrent SAR may be transferred only by 
the method(s) applicable to the underlying option.  In addition, shares 
subject to repurchase by the Company under an early exercise stock purchase 
agreement may be subject to restrictions on transfer which the Board deems 
appropriate.

FEDERAL INCOME TAX INFORMATION

  INCENTIVE STOCK OPTIONS.  Incentive stock options under the Equity Plan are 
intended to be eligible for the favorable federal income tax treatment 
accorded "incentive stock options" under the Code.

  There generally are no federal income tax consequences to the optionee or 
the Company by reason of the grant or exercise of an incentive stock option. 
However, the exercise of an incentive stock option may increase the 
optionee's alternative minimum tax liability, if any.

  If an optionee holds stock acquired through exercise of an incentive stock 
option for at least two years from the date on which the option is granted 
and at least one year from the date on which the shares are transferred to 
the optionee upon exercise of the option, any gain or loss on a disposition 
of such stock will be long-term capital gain or loss.  Generally, if the 
optionee disposes of the stock before the expiration of either of these 
holding periods (a "disqualifying disposition"), at the time of disposition, 
the optionee will realize taxable ordinary income equal to the lesser of (a) 
the excess of the stock's fair market value on the date of exercise over the 
exercise price, or (b) the optionee's actual gain, if any, on the purchase 
and sale.  The optionee's additional gain, or any loss, upon the 
disqualifying disposition will be a capital gain or loss, which will be 
long-term or short-term depending on whether the stock was held for more than 
one year.  Long-term capital gains currently are generally subject to lower 
tax rates than ordinary income.  The maximum capital gains rate for federal 
income tax purposes is currently 28 percent while the maximum ordinary income 
rate is effectively 39.6 percent at the present time.  Slightly different 
rules may apply to optionees who acquire stock subject to certain repurchase 
options or who are subject to Section 16(b) of the Exchange Act.

  To the extent the optionee recognizes ordinary income by reason of a 
disqualifying disposition, the Company will generally be entitled (subject to 
the requirement of reasonableness, the provisions of Section 162(m) of the 
Code and the satisfaction of a tax reporting obligation) to a corresponding 
business expense deduction in the tax year in which the disqualifying 
disposition occurs.

  NONSTATUTORY STOCK OPTIONS.  Nonstatutory stock options granted under the 
Equity Plan generally have the following federal income tax consequences:

  There are no tax consequences to the optionee or the Company by reason of 
the grant of a nonstatutory stock option.  Upon exercise of a nonstatutory 
stock option, the optionee normally will recognize taxable ordinary income 
equal to the excess of the stock's fair market value on the date of exercise 
over the option exercise price.  Generally, with respect to employees, the 
Company is required to withhold from regular wages or supplemental wage 
payments an amount based on the ordinary income recognized.  Subject to the 
requirement of reasonableness, the provisions of Section 162(m) of the Code 
and the satisfaction of a tax reporting obligation, the Company will 

                                        13.

<PAGE>

generally be entitled to a business expense deduction equal to the taxable 
ordinary income realized by the optionee.  Upon disposition of the stock, the 
optionee will recognize a capital gain or loss equal to the difference 
between the selling price and the sum of the amount paid for such stock plus 
any amount recognized as ordinary income upon exercise of the option.  Such 
gain or loss will be long or short-term depending on whether the stock was 
held for more than one year. Slightly different rules may apply to optionees 
who acquire stock subject to certain repurchase options or who are subject to 
Section 16(b) of the Exchange Act.

  RESTRICTED STOCK AND STOCK BONUSES.  Restricted stock and stock bonuses 
granted under the Equity Plan generally have the following federal income tax 
consequences:

  Upon acquisition of stock under a restricted stock or stock bonus award, 
the recipient normally will recognize taxable ordinary income equal to the 
excess of the stock's fair market value over the purchase price, if any. 
However, to the extent the stock is subject to certain types of vesting 
restrictions, the taxable event will be delayed until the vesting 
restrictions lapse, unless the recipient elects pursuant to Section 83(b) of 
the Code to be taxed at the time of receipt of the stock.  Generally, with 
respect to employees, the Company is required to withhold from regular wages 
or supplemental wage payments an amount based on the ordinary income 
recognized. Subject to the requirement of reasonableness, Section 162(m) of 
the Code and the satisfaction of a tax reporting obligation, the Company will 
generally be entitled to a business expense deduction equal to the taxable 
ordinary income realized by the recipient.  Upon disposition of the stock, 
the recipient will recognize a capital gain or loss equal to the difference 
between the selling price and the sum of the amount paid for such stock, if 
any, plus any amount recognized as ordinary income upon acquisition (or 
vesting) of the stock.  Such gain or loss will be long- or short-term 
depending on whether the stock was held for more than one year from the date 
ordinary income is measured. Slightly different rules may apply to persons 
who acquire stock subject to forfeiture under Section 16(b) of the Exchange 
Act.

  STOCK APPRECIATION RIGHTS.  No taxable income is realized upon the receipt 
of a stock appreciation right, but upon exercise of the stock appreciation 
right, the fair market value of the shares (or cash in lieu of shares) 
received must be treated as compensation taxable as ordinary income to the 
recipient in the year of such exercise.  Generally, with respect to 
employees, the Company is required to withhold from the payment made on 
exercise of the stock appreciation right or from regular wages or 
supplemental wage payments an amount based on the ordinary income recognized. 
Subject to the requirement of reasonableness, Section 162(m) of the Code and 
the satisfaction of a reporting obligation, the Company will be entitled to a 
business expense deduction equal to the taxable ordinary income recognized by 
the recipient.

  POTENTIAL LIMITATION ON COMPANY DEDUCTIONS.  As part of the Omnibus Budget 
Reconciliation Act of 1993, the U.S. Congress amended the Code to add Section 
162(m), which denies a deduction to any publicly held corporation for 
compensation paid to certain employees in a taxable year to the extent that 
compensation exceeds $1,000,000 for a covered employee.  It is possible that 
compensation attributable to awards under the Equity Plan, when combined with 
all other types of compensation received by a covered employee from the 
Company, may cause this limitation to be exceeded in any particular year.

  Certain kinds of compensation, including qualified "performance-based 
compensation," are disregarded for purposes of the deduction limitation.  In 
accordance with Treasury regulations issued under Section 162(m) of the Code, 
compensation attributable to stock options and stock appreciation rights will 
qualify as performance-based compensation, provided that: (i) the stock award 
plan contains a per-employee limitation on the number of shares for which 
stock options and stock appreciation rights may be granted during a specified 
period; (ii) the per-employee limitation is approved by the stockholders; 
(iii) the award is granted by a compensation committee comprised solely of 
"outside directors";  and (iv) the exercise price of the award is no less 
than the fair market value of the stock on the date of grant.  Restricted 
stock and stock bonuses qualify as performance-based compensation under these 
Treasury regulations only if:  (i) the award is granted by a compensation 
committee comprised solely of "outside directors"; (ii) the award is granted 
(or exercisable) only upon the achievement of an objective performance goal 
established in writing by the compensation committee while the outcome is 
substantially uncertain; (iii) the compensation committee certifies in 
writing prior to the granting (or exercisability) of the award that the 
performance goal has been satisfied; and (iv) prior to the granting (or 
exercisability) of the award, stockholders have 

                                        14.

<PAGE>

approved the material terms of the award (including the class of employees 
eligible for such award, the business criteria on which the performance goal 
is based, and the maximum amount (or formula used to calculate the amount) 
payable upon attainment of the performance goal).

         NEW PLAN BENEFITS - 1996 EQUITY INCENTIVE PLAN

  The following table presents information with respect to options granted 
under the Equity Plan subject to stockholder approval, to the person and 
groups indicated (to date, no other individuals or groups have been granted 
options under the Equity Plan):

<TABLE>
<CAPTION>
                                                                         Number of Shares
   Name and Position                               Dollar Value ($)(1)  Subject to Options
   -----------------                               -------------------  ------------------
<S>                                                <C>                  <C>
F. Richard Nichol, Ph.D.                                2,539,076            390,627
  President and Chief                                     385,925             59,373 
  Executive Officer                                                       
                                                                          
All Executive Officers as a Group                       2,925,001            450,000  
All Non-Executive Officer Employees as a Group          3,305,973            584,504  

</TABLE>

- ---------------------
(1)  Aggregate exercise price of options.


                           PROPOSAL 4

       RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

  The Board of Directors has selected Ernst & Young LLP as the Company's 
independent auditors for the fiscal year ending December 31, 1997, and has 
further directed that management submit the selection of independent public 
auditors for ratification by the stockholders at the Annual Meeting.  Ernst & 
Young LLP has audited the Company's financial statements since its inception 
in 1989.  Representatives of Ernst & Young LLP are expected to be present at 
the Annual Meeting, at which time they will have an opportunity to make a 
statement if they so desire and will be available to respond to appropriate 
questions.

  Stockholder ratification of the selection of Ernst & Young LLP as the 
Company's independent auditors is not required by the Company's Bylaws or 
otherwise.  However, the Board is submitting the selection of Ernst & Young 
LLP to the stockholders for ratification as a matter of good corporate 
practice. If the stockholders fail to ratify the selection, the Board will 
reconsider whether or not to retain that firm.  Even if the selection is 
ratified, the Board in its discretion may direct the appointment of a 
different independent accounting firm at any time during the year if the 
Board determines that such a change would be in the best interests of the 
Company and its stockholders.

  The affirmative vote of the holders of a majority of the shares present in 
person or represented by proxy and entitled to vote at the meeting will be 
required to ratify the selection of Ernst & Young LLP.

       THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 4.


                                        15.
<PAGE>


                           MANAGEMENT

  Set forth below is information regarding current executive officers of the 
Company:

<TABLE>
<CAPTION>

 Name                           Position with the Company
 ----                           -------------------------
 <S>                            <C>
 F. Richard Nichol, Ph.D.       President and Chief Executive Officer
 David A.H. Lee, M.D., Ph.D.    Executive Vice President, Research and Development
 Eckard Weber, M.D.             Senior Vice President, Research and Drug Discovery
 Joann L. Data, M.D., Ph.D.     Senior Vice President, Clinical Development and Regulatory Affairs
 Rick A. Henson                 President, Pharmaceutical Sales and Marketing Division
 Peter E. Jansen                Vice President and Chief Financial Officer
 Nancy T.Y. Lan, Ph.D.          Vice President, Scientific Affairs and Intellectual Property
 Kelvin W. Gee, Ph.D.           Chief Scientific Officer


</TABLE>

Biographical information about Drs. Nichol, Gee and Weber is set forth under 
PROPOSAL 1 above.

  Dr. Lee, 47, joined the Company as its Executive Vice President, Research 
and Development in December 1992.  From 1980 to December 1992, Dr. Lee held 
various positions at Solvay Duphar, a division of Solvay Corporation, a 
diversified chemicals and health care company in Brussels, Belgium.  Dr. Lee 
served most recently as that company's Vice President, Research and 
Development, Pharmaceutical Division.  Dr. Lee received his M.D. and Ph.D. 
degrees from the University of London.  Dr. Lee is a Member of the Royal 
College of Physicians of London.

  Dr. Data, 53, became the Company's Senior Vice President of Clinical 
Development and Regulatory Affairs in November 1996 after joining the Company 
as Senior Vice President, Regulatory and Medical Affairs in September 1996. 
From 1990 until 1996, Dr. Data held several positions at The Upjohn Company, 
a pharmaceutical company, the most recent of which was Corporate Vice 
President for Worldwide Pharmaceutical Regulatory Affairs and Project 
Management. Previously, she held a number of positions at Hoffmann-La Roche, 
including Vice President of Clinical Research and Development, from 1985 to 
1990.  Dr. Data has been an adjunct assistant professor in medicine and 
pharmacology at Duke University Medical Center since 1982 and at Cornell 
Medical Center since 1986. She earned her M.D. from Washington University 
School of Medicine and her Ph.D. in Pharmacology from Vanderbilt University.

  Mr. Henson, 47, joined the Company as Vice President of Sales in May 1994, 
became Vice President of Sales and Marketing in April 1996 and President, 
Pharmaceutical Sales and Marketing Division in November 1996.  From 1988 to 
May 1994, Mr. Henson held various sales management positions at Ciba-Geigy 
Corporation (now Novartis), a pharmaceutical company, most recently as 
Midwest Regional Sales Director.  Mr. Henson received his B.S. in Education 
from Wichita State University in 1973.

  Mr. Jansen, 60, joined the Company as Vice President and Chief Financial 
Officer in August 1996.  During 1996, he served as Founder, President and 
Chief Executive Officer of Phytomedica Health Products, Inc. ("Phytomedica"), 
which was engaged in the research and development of plant-derived 
pharmaceuticals. From 1992 to 1996, Mr. Jansen was Senior Vice President and 
Chief Financial Officer for Genelabs 


                                        16.

<PAGE>

Technologies, Inc., a biotechnology company.  From 1975 to 1991, he held 
several executive finance positions, including Assistant Corporate Treasurer, 
at Abbott Laboratories.  Mr. Jansen received his B.A. in Business 
Administration from Escola de Administracao de Empresas de Sao Paulo, Brazil, 
and his M.B.A. from Baylor University, where he was a Fulbright scholar. In 
1996, Mr. Jansen filed a petition under Chapter 7 of the Federal Bankruptcy 
Code.  The personal bankruptcy, which was discharged in December 1996, 
resulted from personal obligations incurred to finance Phytomedica.

  Dr. Lan, 50, co-founded the Company in February 1989 and has served as its 
Vice President, Scientific Affairs and Intellectual Property since August 
1996. She also served as Director of Research and Development from August 
through October 1992 and Executive Director of Research and Development from 
October 1992 to January 1993 when she was named Vice President, Research and 
Drug Discovery. Dr. Lan is Adjunct Professor at the University of California, 
Irvine, Department of Pharmacology.  From 1987 to August 1992, she was 
Research Associates Professor of Molecular Pharmacology and Toxicology at the 
University of Southern California School of Pharmacy.  From July 1989 to 
August 1992, she was the Principal Investigator for research sponsored by the 
Company at the University of Southern California.

                                        17.

<PAGE>


                     SECURITY OWNERSHIP OF
            CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

  The following table sets forth certain information regarding the ownership 
of the Company's Common Stock as of April 30, 1997 by: (i) each director and 
nominee for director; (ii) each of the executive officers named in the 
Summary Compensation Table; (iii) all executive officers and directors of the 
Company as a group; and (iv) all those known by the Company to be beneficial 
owners of more than five percent of the Company's Common Stock.

<TABLE>
<CAPTION>
                                                         BENEFICIAL OWNERSHIP (1)
                                                    ----------------------------------
                                                       NUMBER OF       PERCENT OF
 BENEFICIAL OWNER                                       SHARES            TOTAL
 ----------------                                   ----------------  ----------------
<S>                                                 <C>                <C>
Entities Affiliated with Sanderling Ventures (2)
  2730 Sand Hill Road, Suite 200
  Menlo Park, CA 94025...........................   2,556,029          11.27%
Entities affiliated with Domain Associates (3)
  One Palmer Square
  Princeton, NJ 08542............................   2,406,487          10.51%
Novartis Pharma AG
(formerly Ciba-Geigy Limited)
  Klybeckstrasse 141
  Ch-4002, Basel
  Switzerland....................................   2,378,192          10.56%
Robert G. McNeil (2)
  c/o Sanderling Ventures
  2370 Sand Hill Road, Suite 200
  Menlo Park, CA 94025...........................   2,556,029          11.27%
James C. Blair (3)
  c/o Domain Associates
  One Palmer Square
  Princeton, NJ 08542............................   2,406,487          10.51%
Joann L. Data (4)................................       3,750              *
Kelvin W. Gee (5)................................     556,086           2.47%
Rick A. Henson (6)...............................      65,473              *
Peter E. Jansen (7)..............................       5,000              *
Daniel L. Korpolinski (8)........................     400,466           1.75%
Nancy T.Y. Lan (9)...............................     244,547           1.08%
David A. H. Lee (10).............................     253,141           1.11%
Alan C. Mendelson (11)...........................      47,685              *
F. Richard Nichol................................       1,200              *
Timothy J. Rink (12).............................      44,000              *
Lowell E. Sears (13).............................      52,500              *
Eckard Weber (14)................................     581,262           2.57%
All executive officers and directors
as a group (14 persons)(13)......................   7,217,626          29.89%

</TABLE>

- -------------------------
* Less than one percent.


                                         18.

<PAGE>


(1)  This table is based upon information supplied by officers, directors 
     and principal stockholders and Schedules 13D and 13G filed with the 
     Securities and Exchange Commission (the "SEC").  Unless otherwise 
     indicated in the footnotes to this table and subject to community 
     property laws where applicable, the Company believes that each of the 
     stockholders named in this table has sole voting and investment power 
     with respect to the shares indicated as beneficially owned.  Applicable 
     percentages are based on 22,517,321 shares outstanding on April 30, 
     1997, adjusted as required by rules promulgated by the SEC.

(2)  Consists of 882,394 shares held of record by Sanderling Venture 
     Partners III, L.P. ("Sanderling Ventures III") and 69,834 shares 
     issuable to Sanderling Ventures III upon the exercise of currently 
     exercisable warrants; 179,601 shares held of record by Sanderling III 
     Biomedical, L.P. ("Sanderling Biomedical III") and 12,036 shares 
     issuable to Sanderling Biomedical III upon the exercise of currently 
     exercisable warrants; 465,247 shares held of record by Sanderling III 
     Limited, L.P. ("Sanderling III") and 36,175 shares issuable to 
     Sanderling III upon the exercise of currently exercisable warrants; 
     5,032 shares issuable to Sanderling Ventures Management ("Sanderling 
     Ventures Management") upon the exercise of currently exercisable 
     warrants; 385,636 shares held of record by Sanderling Venture Partners 
     II, L.P. ("Sanderling Ventures II"); 196,815 shares held of record by 
     Sanderling Ventures Limited, L.P. ("Sanderling Ventures Limited"); 
     179,601 shares held of record by Sanderling Biomedical, L.P. 
     ("Sanderling Biomedical"); and 99,658 shares held of record by Dr. 
     McNeil and 44,000 shares subject to stock options held by Dr. McNeil 
     exercisable within 60 days of the date of this table. Dr. McNeil, a 
     director of the Company and a general partner of each of Sanderling 
     Biomedical III, Sanderling III, Sanderling Ventures Management, 
     Sanderling Ventures II, Sanderling Ventures Limited and Sanderling 
     Biomedical, has voting and investment power with respect to all of such 
     shares and may be deemed to be the beneficial owner of all such shares.

(3)  Consists of 1,138,212 shares held of record by Domain Partners II, L.P. 
     ("Domain II") and 18,923 shares issuable to Domain II upon the exercise 
     of currently exercisable warrants; 846,154 shares held of record by 
     Domain Partners III, L.P. ("Domain III") and 338,462 shares issuable to 
     Domain III upon the exercise of currently exercisable warrants; 29,615 
     shares held of record by DP III Associates, L.P. ("DP III") and 11,846 
     shares issuable to DP III upon the exercise of currently exercisable 
     warrants; and 15,275 shares held by James C. Blair and 8,000 shares 
     subject to stock options held by Dr. Blair exercisable within 60 days 
     of the date of this table.  Dr. Blair, a director of the Company, is a 
     general partner of the general partner of each of Domain, Domain II, 
     Domain III and DP III.  He has voting and investment power with respect 
     to such shares, and may be deemed to be the beneficial owner of such 
     shares.

(4)  Consists of 3,750 shares subject to stock options held by Dr. Data 
     exercisable within 60 days of the date of this table.

(5)  Includes 24,000 shares subject to stock options held by Dr. Gee 
     exercisable within 60 days of the date of this table and 47,600 shares 
     held of record by members of Dr. Gee's immediate family.

(6)  Includes 62,706 shares subject to stock options held by Mr. Henson 
     exercisable within 60 days of the date of this table.

(7)  Consists of 5,000 shares subject to stock options held by Mr. Jansen 
     exercisable within 60 days of the date of this table.

(8)  Includes 377,342 shares subject to stock options held by Mr. 
     Korpolinski exercisable within 60 days of the date of this table.

(9)  Includes 20,000 shares held of record by Dr. Lan as Custodian and 
     177,350 shares subject to stock options held by Dr. Lan.

                                             19.


<PAGE>


(10) Includes 3,000 shares held of record by Dr. Lee's minor son of 
     which Dr. Lee disclaims beneficial ownership and 224,602 shares subject 
     to stock options held by Dr. Lee exercisable within 60 days of the date 
     of this table.

(11) Consists of 400 shares held in trust for the benefit of Mr. 
     Mendelson's children, of which Mr. Mendelson's spouse is trustee and of 
     which Mr. Mendelson disclaims beneficial ownership; a total of 1,000 
     shares held in two trusts for which Mr. Mendelson has no control over 
     the management of purchases and sales under said trusts and of which 
     Mr. Mendelson disclaims beneficial ownership; 2,746 shares held 
     directly by Mr. Mendelson; 5,385 shares held by CGCH&T SD & PST FBO Mr. 
     Mendelson (the "Mendelson Trust") and 2,154 shares issuable to the 
     Mendelson Trust upon the exercise of currently exercisable warrants; 
     and 36,000 shares subject to stock options held by Mr. Mendelson 
     exercisable within 60 days of the date of this table.

(12) Consists of 44,000 shares subject to stock options held by Dr. Rink 
     exercisable within 60 days of the date of this table.

(13) Consists of 10,500 shares held of record by Mr. Sears, 38,000 shares 
     subject to stock options held by Mr. Sears exercisable within 60 days 
     of the date of this table and 4,000 shares issuable upon the exercise 
     of currently exercisable warrants.

(14) Consists of 490,671 shares held of record by Dr. Weber, and 90,591 
     shares subject to stock options held by Dr. Weber exercisable within 60 
     days of the date of this table.

(15) Includes 4,303,275 shares held by entities affiliated with two 
     directors; 1,135,341 shares subject to stock options held by all 
     officers and directors exercisable within 60 days of the date of this 
     table; and 498,462 shares issuable upon the exercise of currently 
     exercisable warrants held by certain officers and entities affiliated 
     with two directors.  See Notes (2) through (14) above.


                                        20.

<PAGE>




     COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934

  Section 16(a) of the Exchange Act ("Section 16(a)") requires the Company's 
directors and executive officers, and persons who own more than 10 percent of 
a registered class of the Company's equity securities, to file with the 
Commission initial reports of ownership and reports of changes in ownership 
of Common Stock and other equity securities of the Company.  Officers, 
directors and greater than 10 percent stockholders are required by Commission 
regulation to furnish the Company with copies of all Section 16(a) forms they 
file.

  To the Company's knowledge, based solely on a review of the copies of such 
reports furnished to the Company and written representations that no other 
reports were required, during the fiscal year ended December 31, 1996, all 
Section 16(a) filing requirements applicable to its officers, directors and 
greater than 10 percent beneficial owners were complied with.

                           EXECUTIVE COMPENSATION

COMPENSATION OF DIRECTORS

  Each non-employee director of the Company receives stock options under the 
Directors' Plan as compensation for services on the Board of Directors.  
Option grants under the Directors' Plan are automatic and non-discretionary.  
For a description of the Directors' Plan, see PROPOSAL 2 above.  During the 
last fiscal year, Drs. Blair, McNeil and Rink and Mr. Mendelson received 
options to purchase 4,000 shares of the Company's Common Stock, and Mr. Sears 
received an option to purchase 8,000 shares.  As of April 30, 1997, 8,000 
options had been exercised under the Directors' Plan.

  Each non-employee director of the Company receives a fee of $2,500 for each 
meeting of the Board attended by such non-employee director in person, $500 
for each telephonic meeting of the Board and $500 for each committee meeting 
attended by such non-employee director.  The Chairman of the Board receives 
an additional $500 per month. All non-employee directors are reimbursed for 
expenses incurred in connection with attendance at meetings of the Board of 
Directors and committees thereof in accordance with Company policy.   In the 
fiscal year ended December 31, 1996, the total cash compensation paid to 
non-employee directors was $70,500.

    Mr. Sears and the Company entered into an agreement, effective as of 
October 1996, pursuant to which Mr. Sears shall be paid $3,300 per eight-hour 
day for additional services performed as Chairman, payable one-third in cash 
and two-thirds in common stock of the Company.  In the fiscal year ended 
December 31, 1996, Mr. Sears received $1,104 cash compensation under the 
agreement.  No shares of common stock have yet been issued to Mr. Sears under 
the agreement.

  Directors who are employees of the Company do not receive separate 
compensation for their services as directors.

COMPENSATION OF EXECUTIVE OFFICERS

  In addition to cash compensation, the Company's executive officers are 
eligible to receive stock options under the 1990 Stock Option Plan (the "1990 
Plan") and to receive stock options and other stock awards under the Equity 
Plan.  For a description of the Equity Plan, see PROPOSAL 3 above.  The 1990 
Plan provides for grants of ISOs and NSOs.  An aggregate of 3,369,000 shares 
of Common Stock have been reserved for issuance under the 1990 Plan.  As of 
May 19, 1997, options to purchase 2,643,789 shares of Common Stock were 
outstanding under the 1990 Plan and 240,276 shares remained available for 
issuance. Options may be granted under the 1990 Plan to employees (including 
officers), directors and consultants, although ISOs may be granted only to 
employees (including officers).  The 1990 Plan provides that, in the event of 
dissolution, liquidation or sale of substantially all of the assets of the 
Company, a merger or consolidation in which the Company is not the surviving 
corporation or a reverse merger in which the Company is the surviving 
corporation but the shares of the Common Stock outstanding immediately 
preceding the merger are converted by virtue of the merger into other 
property, whether 


                                        21.

<PAGE>

in the form of securities, cash or otherwise, then to the extent permitted by 
applicable law: (i) any surviving corporation shall assume any options 
outstanding under the 1990 Plan or shall substitute similar options for those 
outstanding under the 1990 Plan, or (ii) such options shall continue in full 
force and effect.  In the event any surviving corporation refuses to assume 
or continue such options, or to substitute similar options for those 
outstanding under the 1990 Plan, then the time during which such options may 
be exercised shall be accelerated and the options terminated if not exercised 
prior to such event.

  The following table shows for the fiscal years ended December 31, 1996, 
1995 and 1994, certain compensation awarded or paid to or earned by the 
Company's Chief Executive Officer and its other four most highly compensated 
executive officers (the "Named Executive Officers") at December 31, 1996:

<TABLE>
<CAPTION>


                           SUMMARY COMPENSATION TABLE 

                                                                                LONG-TERM 
                                                          ANNUAL              COMPENSATION 
                                                       COMPENSATION              AWARDS/
                                                  ----------------------       SECURITIES 
                                                                               UNDERLYING         ALL OTHER 
        NAME AND PRINCIPAL                        SALARY          BONUS          OPTIONS        COMPENSATION 
             POSITION                 YEAR         ($)             ($)              (#)               ($)   
- ---------------------------------     ----    ------------     -----------    --------------   --------------
<S>                                   <C>     <C>              <C>             <C>             <C>           
 Daniel L. Korpolinski (1)            1996    265,000 (2)       79,500 (3)             --          8,789 (4) 
   Former President and Chief         1995    244,750           95,493 (5)        200,000         39,553 (7) 
   Executive Officer                  1994    224,500           60,494 (6)             --         38,574 (7) 

 David A. H. Lee M.D., Ph.D. (1)      1996    220,917           73,793 (8)         40,000         28,572 (11) 
   Executive Vice President,          1995    206,433           69,610 (9)        125,000         27,542 (7) 
   Research and                       1994    191,267           54,610 (10)            --         23,731 (12) 
   Development 

 Eckard Weber, M.D. (1)               1996    202,083           35,000             40,000             -- 
   Senior Vice President,             1995    121,917(13)           --                 --             -- 
   Research and Drug 
   Discovery 

 Peter E. Jansen (1)(14)              1996    72,917            28,229            115,000         28,193 (15) 
   Vice President and 
   Chief Financial Officer 

 Rick A. Henson (16)                  1996    154,750           97,828 (17)       120,000         42,943 (19) 
   President, Pharmaceutical          1995    136,250           59,012 (18)        60,000         18,058 (7) 
   Sales and Marketing 
   Division 

 Nancy T.Y. Lan, Ph.D.                1996    145,294           37,210             95,000          1,453 (20) 
   Vice President, Scientific         1995    138,375               --                 --
   Affairs and Intellectual           1994    130,750               --                 --
   Property 

 Joann L. Data, Ph.D. (21)            1996    66,667            56,667            120,000         60,410 (22) 
   Senior Vice President, 
   Clinical Development and 
   Regulatory Affairs 

</TABLE>
- ---------------------------

                                        22.

<PAGE>

(1)  Mr. Korpolinski resigned his positions with the Company on October 30,
     1996.  Drs. Lee and Weber and Mr. Jansen served as the Company's Office of
     the President from November 1, 1996 until January 29, 1997, when F.
     Richard Nichol, Ph.D. became the Company's President and Chief Executive
     Officer.
(2)  Includes payment of $44,167 pursuant to a Transition and Consulting
     Agreement between the Company and Mr. Korpolinski.
(3)  Paid pursuant to a Transition and Consulting Agreement between the Company
     and Mr. Korpolinski.
(4)  Consists of $2,650 in 401(k) employer matching contributions and payments
     for term life insurance and tax gross-up.
(5)  Consists of a cash bonus of $60,000 and cancellation of indebtedness and
     related interest in the amount of $35,493.
(6)  Consists of a cash bonus of $25,000 and cancellation of indebtedness and
     related interest in the amount of $35,494.
(7)  Consists of payments for term life insurance and tax gross-ups.
(8)  Consists of cash bonus of $44,183 and cancellation of indebtedness and
     related interest in the amount of $29,610.
(9)  Consists of a cash bonus of $40,000 and cancellation of indebtedness and
     related interest in the amount of $29,610.
(10) Consists of a cash bonus of $25,000 and cancellation of indebtedness and
     related interest in the amount of $29,610.
(11) Consists of $2,209 in 401(k) employer matching contributions and tax 
     gross-up in connection with cancellation of indebtedness.
(12) Consists of tax gross-up in connection with cancellation of indebtedness.
(13) Includes consulting payments to Dr. Weber prior to his becoming an
     executive officer of the Company.
(14) Mr. Jansen joined the Company on August 1, 1996.
(15) Consists of relocation expenses of $10,208 and tax gross-ups.
(16) Mr. Henson became an executive officer in 1995.
(17) Consists of cash bonuses of $51,316 and cancellation of indebtedness and
     related interest in the amount of $46,512.
(18) Consists of a cash bonus of $36,879 and cancellation of indebtedness and
     related interest in the amount of $22,183.
(19) Consists of $1,548 in 401(k) employer matching contributions and tax 
     gross-up for mortgage forgiveness and related interest.
(20) Consists of 401(k) employer matching contributions.
(21) Dr. Data joined the Company on August 15, 1996.
(22) Consists of relocation expenses of $13,127 and tax gross-ups.



                                        23.

<PAGE>


                       STOCK OPTION GRANTS AND EXERCISES

  The following tables show for the fiscal year ended December 31, 1996, 
certain information regarding options granted to, exercised by and held at 
year end by, the Named Executive Officers:

                       OPTION GRANTS IN LAST FISCAL YEAR

<TABLE>
<CAPTION>


                                                       INDIVIDUAL GRANTS    
                            -----------------------------------------------------------------------------   POTENTIAL REALIZABLE
                                                                                                            VALUE AT ASSUMED
                                                                                                 VALUE AT   ANNUAL RATES OF STOCK
                            NUMBER OF        % OF TOTAL                                          GRANT      PRICE APPRECIATION FOR
                            SECURITIES       OPTIONS/SARs    EXERCISE  MARKET                    DATE       OPTION TERM(3)
                            UNDERLYING       GRANTED TO      OR BASE   PRICE ON                  MARKET    ------------------------
                            OPTIONS/SARs     EMPLOYEES IN    PRICE     DATE OF     EXPIRATION    PRICE 
NAME                        GRANTED(#)(1)    FISCAL YEAR(2)  ($/SH)    GRANT       DATE          0% ($)        5% ($)      10% ($)
- -------------------------   -------------   ---------------  --------  ---------   ----------   ----------  ---------  -------------
<S>                         <C>             <C>              <C>       <C>         <C>          <C>         <C>        <C>
 Daniel L. Korpolinski . .        --             --              --         --            --          --          --          -- 

 David A. H. Lee . . . . .    40,000            4.2           5.875      5.875      12/16/06          --     147,790     374,529 

 Eckard Weber, M.D.  . . .    40,000            4.2           5.875      5.875      12/16/06          --     147,790     374,529 
 
 Peter E. Jansen . . . . .    75,000            7.8           3.438      6.875      08/01/06     257,813     582,086   1,079,586 
                              40,000            4.2           5.875      5.875      12/16/06          --     147,790     374,529 

 Rick A. Henson  . . . . .    70,000            7.3           8.875      8.875      01/01/06          --     390,701     990,113 
                              50,000            5.2           5.875      5.875      12/16/06          --     208,321     527,927 

 Nancy T.Y. Lan, Ph.D. . .    65,000            6.8           3.250      6.500      04/10/06     211,250     278,436     568,494 
                              30,000            3.1           5.875      5.875      12/16/06          --     110,843     280,897 
 
 Joann L. Data, Ph.D.  . .    90,000            9.4           3.500      7.000      09/01/06     315,000     711,204   1,319,058 
                              30,000            3.1           5.875      5.875      12/16/06          --     110,843     280,897 

</TABLE>
- ------------------------

(1)  Unless otherwise indicated, options generally vest at the rate of 25
     percent on the first anniversary date of grant and 1/48th per month
     thereafter over the next 36 months so that the grant is fully-vested four
     years from the date of grant.  The options shall continue in full force
     and effect upon a change in control, as defined in the Company's option
     plans, unless the acquiring company refuses to continue or assume said
     options or to substitute similar options, in which event the vesting of
     such options shall be accelerated.  The Board of Directors may reprice
     options under the terms of the Company's option plans.

(2)  Based on options covering 961,000 shares granted in 1996.

(3)  The potential realizable value is calculated based on the term of the
     option at its time of grant (10 years).  It is calculated by assuming that
     the stock price on the date of grant appreciates at the indicated annual
     rate, compounded annually for the entire term of the option and that the
     option is exercised and sold on the last day of its term for the
     appreciated stock price.  No gain to the optionee is possible unless the
     stock price increases over the option term.


                                        24.

<PAGE>



     The following table shows for the fiscal year ended December 31, 1996, 
certain information regarding options exercised by and held at year end by 
the Named Executive Officers:

  AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FY-END OPTION VALUES

<TABLE>
<CAPTION>

                                                                 NUMBER OF SECURITIES  
                                                                     UNDERLYING             VALUE OF UNEXERCISED 
                                                                 UNEXERCISED OPTIONS        IN-THE-MONEY OPTIONS
                                                                    AT FY-END (#)               AT FY-END ($)
                              SHARES AQUIRED     VALUE             EXERCISABLE/                EXERCISABLE/   
NAME                          ON EXERCISE (#)  REALIZED ($)        UNEXERCISABLE              UNEXERCISABLE (1)
- ------------------------      ---------------  ------------        -------------              -----------------
<S>                           <C>              <C>                <C>                         <C> 
Daniel L. Korpolinski..              --             --            357,030/121,875                1,688,261/0
David A. H. Lee........          11,000         72,875            203,978/128,021              899,211/24,414
Eckard Weber, M.D......              --             --             66,841/161,375              110,943/31,500
Peter E. Jansen........              --             --               0/115,000                    0/173,438
Rick A. Henson.........              --             --             27,916/172,083               54,893/30,107
Nancy T.Y. Lan Ph.D....              --             --             173,600/30,000                 732,650/0
Joann L. Data, Ph.D....              --             --                0/120,000                   0/202,500

</TABLE>

- -------------------------

(1)  Fair market value of the Company's Common Stock at December 31, 1996
     ($5.75) minus the exercise price of the options.

EMPLOYMENT AND SEVERANCE AGREEMENTS

  In August 1992, the Company entered into an agreement with Dr. Lee for his 
employment with the Company and his initial base salary and annual bonus. Dr. 
Lee's employment under the agreement may be terminated at any time, with or 
without cause.  The agreement further provides that in the event he is 
terminated other than for cause, Dr. Lee will continue to receive his 
standard group benefits, insurance benefits and base salary for four months 
after the effective date of notice of termination.

  In October 1996, the Company entered into an agreement with Mr. Henson 
pursuant to which Mr. Henson receives an initial base salary of $190,000 per 
year and an annual bonus of 20 to 25 percent of his base salary based on 
achieving certain performance objectives, paid in equal quarterly 
installments. Mr. Henson was also granted stock options for 50,000 shares of 
the common stock of the Company.  Mr. Henson's employment under the agreement 
may be terminated at any time, with or without cause.  The agreement further 
provides that in the event Mr. Henson is terminated other than for cause, Mr. 
Henson will continue to receive his base salary until he accepts an offer of 
employment or for a maximum period of twelve (12) consecutive months.

  In January 1997, the company entered into a severance agreement with Dr. 
Nichol which provides that, in the event of any termination of employment 
without cause, the Company will continue payment of Dr. Nichol's base salary 
for a period of six months.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

  The Compensation Committee of the Board of Directors currently is composed 
of Drs. Blair, McNeil and Rink and Mr. Sears.  Mr. Mendelson served on the 
Compensation Committee during 1996 until June 11.  Mr. Mendelson, Secretary 
and a director of the Company, is a partner of Cooley Godward LLP, counsel to 
the Company.


                                        25.

<PAGE>


              REPORT OF THE COMPENSATION COMMITTEE
                   ON EXECUTIVE COMPENSATION(1)

  The Compensation Committee (the "Committee") sets the Company's 
compensation policies, evaluates performance and determines the compensation 
of executive officers.  During the year ended December 31, 1996, the 
Committee was composed of Drs. Blair and Rink and Mr. Mendelson until June 11 
and has since been composed of Drs. Blair, McNeil and Rink and Mr. Sears.  
The Committee attempts to design compensation policies that will attract and 
retain the highest quality executives, reward them for the Company's progress 
and motivate them to enhance long-term stockholder value.  The key components 
of the Company's executive compensation program are cash compensation and 
stock options.

  Section 162(m) of the Code limits the Company to a deduction for federal 
income tax purposes of no more than $1 million of compensation paid to 
certain Named Executive Officers in a taxable year.  Compensation above $1 
million may be deducted if it is "performance-based compensation" within the 
meaning of the Code.  Stock options granted to its Named Executive Officers 
under the Equity Plan and under the 1990 Plan, as amended, in each case with 
exercise prices at least equal to the fair market value of the Common Stock 
on the date of grant shall be treated as "performance-based compensation."

  In evaluating the Company's executive officers and making compensation 
decisions, the Committee makes a subjective assessment of a variety of 
factors, both corporate and individual.  These factors include, in order of 
importance, the progress of the Company toward its identified objectives; the 
individual contributions to the Company by each officer, determined by the 
extent to which each officer achieves certain management by objective targets 
("MBOs") established by the Committee; and the compensation paid by selected 
biotechnology companies to individuals in comparable positions.  The 
companies examined may, but need not, include those comprising the H&Q 
Biotechnology Index.  The weight of these factors in the case of a particular 
individual's compensation may vary.  When using comparative data, the 
Committee attempts to set compensation levels in the mid-range of management 
compensation at the companies examined.  In awarding stock options, the 
Committee considers the number and value of an executive officer's 
outstanding stock options.

  As the Company has developed, the measures of its progress have changed, 
and the Committee expects them to continue to change.  At this point in the 
Company's evolution, the measures the Committee looks to in evaluating the 
Company's progress when determining compensation for executive officers are 
the advancing of the Company's lead products through development and clinical 
testing, the recruiting of a high quality management team, the planning and 
entering into of appropriate collaborative arrangements with larger 
pharmaceutical and biotechnology companies relating to the development of 
other products and the foreign distribution of the Company's lead products, 
and the securing of sufficient capital to enable the Company to complete 
development and achieve significant revenues.  The MBOs include these factors.

  Daniel L. Korpolinski served as the Company's Chief Executive Officer until 
his resignation on October 30, 1996.  Mr. Korpolinski's 1996 base salary was 
based largely on 1995 performance.  In 1995, the Company achieved several key 
objectives.  These achievements included obtaining allowance of the IND for 
the Company's lead anti-stroke compound and completion of certain Phase I 
safety studies, entering into a co-development and co-promotion collaboration 
with Warner-Lambert Company and its Parke-Davis division, negotiating a 
co-promotion collaboration with Somerset Pharmaceuticals that was signed in 
January 1996 and raising approximately $34 million through equity financings, 
including investments by corporate partners, a private placement and a public 
offering which was consummated in January 1996.  Accordingly, the Committee 
deemed it appropriate and consistent with these significant accomplishments 
to increase Mr. Korpolinski's base salary to $265,000 for 1996.  All payments 
to Mr. Korpolinski subsequent to his resignation were made pursuant to a 
Transition and Consulting Agreement 

- -----------------------------

(1)  This section is not "soliciting material," is not deemed "filed" with the
SEC and is not to be incorporated by reference in any filing of the Company
under the Securities Act or the Exchange Act whether made before or after the
date hereof and irrespective of any general incorporation language in any such
filing.


                                        26.
<PAGE>


between the Company and Mr. Korpolinski. Subsequent to Mr. Korpolinski's 
resignation, Mr. Jansen and Drs. Lee and Weber served as an interim Office of 
the President until F. Richard Nichol became the Company's Chief Executive 
Officer in January 1997.  Mr. Jansen and Drs. Lee and Weber did not receive 
additional compensation for such service.

                                   James C. Blair
                                   Robert G. McNeil, Ph.D.
                                   Alan C. Mendelson
                                   Timothy J. Rink
                                   Lowell E. Sears


                PERFORMANCE MEASUREMENT COMPARISON(1)

  The following chart shows the value of an investment of $100 on January 29, 
1993 in the Nasdaq Stock Market-U.S. Index, the H&Q Biotechnology Index and 
the Company's Common Stock:

          Comparison of Total Cumulative Return on Investment

                             Nasdaq Stock Market-        H&O Biotechnology
Dates          CoCensys             U.S.                       Sector
- -----          --------     ----------------------     ---------------------
Jan-93         100                 100                         100
Dec-93          44.44              111.62                       96.01
Dec-94          33.33              109.11                       91.21
Dec-95          88.89              154.31                      155.14
Dec-96          63.89              189.76                      143.15



(1)  This section is not "soliciting material," is not deemed "filed" with the
SEC and is not to be incorporated by reference in any filing of the Company
under the Securities Act or the Exchange Act whether made before or after the
date hereof and irrespective of any general incorporation language in any such
filing.


                                        27.

<PAGE>


                             CERTAIN TRANSACTIONS

LOANS TO OFFICERS

  In May 1993, in connection with his relocation to California, the Company 
made a secured loan in the principal amount of $100,000 to Dr. Lee.  The loan 
bears interest at the rate of 8.5 percent per year and is secured by a deed 
of trust on Dr. Lee's residence.  The loan is repayable over four years in 
equal monthly installments.  As of March 31, 1997, principal in the amount of 
$4,734.82 was outstanding on the loan.

  In July 1994, in connection with his relocation to California, the Company 
made two secured loans, each in the principal amount of $75,000, to Mr. 
Henson. One loan bears interest at the rate of 8.5 percent per year;  the 
other does not bear interest.  Both loans are secured by deeds of trust on 
Mr. Henson's residence.   The non-interest bearing loan was amended in 1996 
such that it will be due and payable on December 31, 1999, subject to 
forgiveness over four years in equal annual installments of $18,750 as long 
as Mr. Henson continues to be employed by the Company.  As of March 31, 1997, 
the aggregate principal amount of $81,072 was outstanding on the loans.

  In January 1997, in connection with her relocation to California, the 
Company made a secured loan in the principal amount of $100,000 to Dr. Data. 
The loan bears no interest until January 31, 2001 and is secured by a deed of 
trust on Dr. Data's home.  The loan is repayable over four years in equal 
monthly installments.  As of March 31, 1997, principal in the amount of 
$96,519 was outstanding on the loan.

INDEMNIFICATION AGREEMENTS

  The Company has entered into indemnity agreements with certain officers and 
directors which provide, among other things, that the Company will indemnify 
such officer or director, under the circumstances and to the extent provided 
therein, for expenses, damages, judgments, fines and settlements he or she 
may be required to pay in actions or proceedings which he or she is or may be 
made a party by reason of his position as a director, officer or other agent 
of the Company, and otherwise to the full extent permitted under Delaware law 
and the Company's Bylaws.

See "Compensation on Committee Interlocks and Insider Participation."

                             OTHER MATTERS

  The Board of Directors knows of no other matters that will be presented for 
consideration at the Annual Meeting.  If any other matters are properly 
brought before the meeting, it is the intention of the persons named in the 
accompanying proxy to vote on such matters in accordance with their best 
judgment.

                                   By Order of the Board of Directors,

                                   /s/ Alan C. Mendelson

                                   Alan C. Mendelson
                                   Secretary


May 23, 1997


                                        28.



y<PAGE>

                                 COCENSYS, INC.
                 1992 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

                         ADOPTED AS OF DECEMBER 9, 1992
                    APPROVED BY STOCKHOLDERS JANUARY 4, 1993
                 AMENDED BY BOARD OF DIRECTORS NOVEMBER 8, 1994
                     APPROVED BY STOCKHOLDERS JUNE 14, 1995
                 AMENDED BY BOARD OF DIRECTORS DECEMBER 16, 1996
                 AMENDED BY BOARD OF DIRECTORS FEBRUARY 12, 1997
                   APPROVED BY STOCKHOLDERS __________________

1.   PURPOSE

     (a)  The purpose of the 1992 Non-Employee Directors' Stock Option Plan 
(the "Plan") is to provide a means by which each director of CoCensys, Inc. 
(the "Company") who is not otherwise an employee of the Company or of any 
Affiliate of the Company (each such person being hereafter referred to as a 
"Non-Employee Director") will be given an opportunity to purchase stock of 
the Company.

     (b)  The word "Affiliate" as used in the Plan means any parent 
corporation or subsidiary corporation of the Company as those terms are 
defined in Sections 424(e) and (f), respectively, of the Internal Revenue 
Code of 1986, as amended from time to time (the "Code").

     (c)  The Company, by means of the Plan, seeks to retain the services of 
persons now serving as Non-Employee Directors of the Company, to secure and 
retain the services of persons capable of serving in such capacity, and to 
provide incentives for such persons to exert maximum efforts for the success 
of the Company.

2.   ADMINISTRATION

     (a)  The Plan shall be administered by the Board of Directors of the 
Company (the "Board") unless and until the Board delegates administration to 
a committee, as provided in subparagraph 2(b).

                                        1.

<PAGE>

     (b)  The Board may delegate administration of the Plan to a committee 
composed of one (1) or more members of the Board (the "Committee").  If 
administration is delegated to a Committee, the Committee shall have, in 
connection with the administration of the Plan, the powers theretofore 
possessed by the Board, subject, however, to such resolutions, not 
inconsistent with the provisions of the Plan, as may be adopted from time to 
time by the Board.  The Board may abolish the Committee at any time and 
revest in the Board the administration of the Plan.

3.   SHARES SUBJECT TO THE PLAN

     (a)  Subject to the provisions of paragraph 10 relating to adjustments 
upon changes in stock, the stock that may be sold pursuant to options granted 
under the Plan shall not exceed in the aggregate three hundred fifty thousand 
(350,000) shares of the Company's common stock.  If any option granted under 
the Plan shall for any reason expire or otherwise terminate without having 
been exercised in full, the stock not purchased under such option shall again 
become available for the Plan.

     (b)  The stock subject to the Plan may be unissued shares or reacquired 
shares, bought on the market or otherwise.

4.   ELIGIBILITY

     Options shall be granted only to Non-Employee Directors of the Company.

5.   NON-DISCRETIONARY GRANTS

     (a)  Upon the date of the approval of the Plan by the Board (the 
"Adoption Date"), each person who is then a Non-Employee Director shall be 
granted an option to purchase twenty thousand (20,000) shares of common stock 
of the Company on the terms and conditions set forth herein; provided, 
however, that a Non-Employee Director who is then serving as Chairman of 


                                        2.

<PAGE>

the Board of Directors shall be granted an option to purchase forty thousand 
(40,000) shares of common stock of the Company on the terms and conditions 
set forth herein.  Such options shall commence vesting on January 1, 1993, as 
provided for in subparagraph 6(e).

     (b)  Each person who is, after the Adoption Date, elected for the first 
time to be a Non-Employee Director shall, upon the date of his initial 
election to be a Non-Employee Director by the Board or stockholders of the 
Company, be granted an option to purchase twenty thousand (20,000) shares of 
common stock of the Company on the terms and conditions set forth herein.  
Such options shall commence vesting on their respective grant dates, as 
provided for in subparagraph 6(e).

     (c)  In addition to options granted pursuant to subparagraphs 5(a) and 
5(b), on January 2nd of each year, each Non-Employee Directors shall be 
granted an option to purchase eight thousand (8,000) shares of common stock 
of the Company; provided, however, that the Chairman of the Board shall 
instead receive an option to purchase twelve thousand (12,000) shares.  
Notwithstanding the provisions of subparagraph 6(e), options granted pursuant 
to this subparagraph 5(c) shall vest in full one year from the date of grant, 
provided that the optionee has, during such year, (i) continuously served as 
a Non-Employee director or as an employee of or consultant to the Company and 
(ii) attended seventy-five percent (75%) or greater of the aggregate of the 
total number of meetings of the Board of Directors and any committees upon 
which he served during the period of such service.

6.   OPTION PROVISIONS

     Each option shall contain the following terms and conditions:

     (a)  The term of each option commences on the date it is granted and, 
unless sooner terminated as set forth herein, expires on the date 
("Expiration Date") ten (10) years from the 


                                        3.

<PAGE>

date of grant.  If the optionee's service as a Non-Employee Director of the 
Company terminates for any reason or for no reason, the option shall 
terminate on the earlier of the Expiration Date or the date three (3) months 
following the date of termination of service; provided, however, that if such 
termination of service is due to the optionee's death, the option shall 
terminate on the earlier of the Expiration Date or twelve (12) months 
following the date of the optionee's death.  In any and all circumstances, an 
option may be exercised following termination of the optionee's service as a 
Non-Employee Director of the Company only as to that number of shares as to 
which it was exercisable on the date of termination of such service under the 
provisions of subparagraph 6(e).

     (b)  The exercise price of each option granted pursuant to subparagraph 
5(a) shall be $5.00 per share, which exceeds one hundred ten percent (110%) 
of the fair market value of the common stock of the Company on such date.  
The exercise price of each option granted pursuant to subparagraphs 5(b) and 
5(c) shall be one hundred percent (100%) of the fair market value of the 
stock subject to such option on the date such option is granted.

     (c)  Payment of the exercise price of each option is due in full in cash 
upon any exercise when the number of shares being purchased upon such 
exercise is less than one thousand (1,000) shares; but when the number of 
shares being purchased upon an exercise is one thousand (1,000) or more 
shares, the optionee may elect to make payment of the exercise price under 
one of the following alternatives:

          (i)   Payment of the exercise price per share in cash at the time 
of exercise; or

          (ii)  Provided that at the time of the exercise the Company's 
common stock is publicly traded and quoted regularly in the Wall Street 
Journal, payment by delivery of shares 

                                        4.

<PAGE>


of common stock of the Company already owned by the optionee, held for the 
period required to avoid any charge to the Company's reported earnings that 
would not be incurred if the exercise price was paid in cash, and owned free 
and clear of any liens, claims, encumbrances or security interest, which 
common stock shall be valued at fair market value on the date preceding the 
date of exercise; or

          (iii) Payment by a combination of the methods of payment specified 
in subparagraphs 6(c)(i) and 6(c)(ii) above.

     (d)  An option may be transferable to the extent provided in the option 
agreement; provided that if the option agreement does not expressly permit 
the transfer of an option, the option shall not be transferable except by 
will, by the laws of descent and distribution or by a domestic relations 
order satisfying the requirements of Rule 16b-3 of the Securities Exchange 
Act of 1934, as amended ("Rule 16b-3"), and shall be exercisable during the 
lifetime of the person to whom the option is granted only by such person or 
by his guardian or legal representative or transferee pursuant to a domestic 
relations order.

     (e)  The option shall become exercisable in installments over a period 
of five (5) years from the date such option commences vesting pursuant to 
subparagraph 5(a) or 5(b) (the "Vesting Start Date") at the rate of twenty 
percent (20%) in five (5) equal annual installments commencing on the date 
one (1) year after the Vesting Start Date of the option, provided that the 
optionee has, during the prior one (1) year period, (i) continuously served 
as a Non-Employee Director or as an employee of or consultant to the Company 
or any Affiliate of the Company, and (ii) attended seventy-five percent (75%) 
or greater of the aggregate of the total number of meetings of the Board of 
Directors and the total number of meetings held by all committees of the 
Board of Directors on which he served, during the period for which he has 


                                        5.

<PAGE>

been a director or served on such committees.  Such option shall become fully 
exercisable in accordance with its terms with respect to that portion of the 
shares represented by that installment.  Failure of the optionee to meet the 
conditions for any annual installment becoming exercisable, as set forth 
above, shall not affect the exercisability of future annual installments.

     (f)  The Company may require any optionee, or any person to whom an 
option is transferred under subparagraph 6(d), as a condition of exercising 
any such option:  (i) to give written assurances satisfactory to the Company 
as to the optionee's knowledge and experience in financial and business 
matters; and (ii) to give written assurances satisfactory to the Company 
stating that such person is acquiring the stock subject to the option for 
such person's own account and not with any present intention of selling or 
otherwise distributing the stock.  These requirements, and any assurances 
given pursuant to such requirements, shall be inoperative if (i) the issuance 
of the shares upon the exercise of the option has been registered under a 
then-currently-effective registration statement under the Securities Act of 
1933, as amended (the "Securities Act"), or (ii), as to any particular 
requirement, a determination is made by counsel for the Company that such 
requirement need not be met in the circumstances under the then-applicable 
securities laws.

     (g)  Notwithstanding anything to the contrary contained herein, an 
option may not be exercised unless the shares issuable upon exercise of such 
option are then registered under the Securities Act or, if such shares are 
not then so registered, the Company has determined that such exercise and 
issuance would be exempt from the registration requirements of the Securities 
Act.


                                        6.

<PAGE>


7.   COVENANTS OF THE COMPANY

     (a)  During the terms of the options granted under the Plan, the Company 
shall keep available at all times the number of shares of stock required to 
satisfy such options.

     (b)  The Company shall seek to obtain from each regulatory commission or 
agency having jurisdiction over the Plan such authority as may be required to 
issue and sell shares of stock upon exercise of the options granted under the 
Plan; provided, however, that this undertaking shall not require the Company 
to register under the Securities Act either the Plan, any option granted 
under the Plan, or any stock issued or issuable pursuant to any such option.  
If the Company is unable to obtain from any such regulatory commission or 
agency the authority which counsel for the Company deems necessary for the 
lawful issuance and sale of stock under the Plan, the Company shall be 
relieved from any liability for failure to issue and sell stock upon exercise 
of such options.

8.   USE OF PROCEEDS FROM STOCK

     Proceeds from the sale of stock pursuant to options granted under the 
Plan shall constitute general funds of the Company.

9.   MISCELLANEOUS

     (a)  Neither an optionee nor any person to whom an option is transferred 
under subparagraph 6(d) shall be deemed to be the holder of, or to have any 
of the rights of a holder with respect to, any shares subject to such option 
unless and until such person has satisfied all requirements for exercise of 
the option pursuant to its terms.

     (b)  Throughout the term of any option granted pursuant to the Plan, the 
Company shall make available to the holder of such option, not later than one 
hundred twenty (120) days after the close of each of the Company's fiscal 
years during the option term, upon request, such 


                                        7.

<PAGE>

financial and other information regarding the Company as comprises the annual 
report to the stockholders of the Company provided for in the Bylaws of the 
Company and such other information regarding the Company as the holder of 
such option may reasonably request.

     (c)  Nothing in the Plan or in any instrument executed pursuant thereto 
shall confer upon any Non-Employee Director any right to continue in the 
service of the Company or any Affiliate or shall affect any right of the 
Company, its Board or stockholders or any Affiliate to terminate the service 
of any Non-Employee Director with or without cause.

     (d)  No Non-Employee Director, individually or as a member of a group, 
and no beneficiary or other person claiming under or through him, shall have 
any right, title or interest in or to any option reserved for the purposes of 
the Plan except as to such shares of common stock, if any, as shall have been 
reserved for him pursuant to an option granted to him.

     (e)  In connection with each option made pursuant to the Plan, it shall 
be a condition precedent to the Company's obligation to issue or transfer 
shares to a Non-Employee Director, or to evidence the removal of any 
restrictions on transfer, that such Non-Employee Director make arrangements 
satisfactory to the Company to insure that the amount of any federal or other 
withholding tax required to be withheld with respect to such sale or 
transfer, or such removal or lapse, is made available to the Company for 
timely payment of such tax.

10.  ADJUSTMENTS UPON CHANGES IN STOCK

     (a)  If any change is made in the stock subject to the Plan, or subject 
to any option granted under the Plan (through merger, consolidation, 
reorganization, recapitalization, stock dividend, dividend in property other 
than cash, stock split, liquidating dividend, combination of shares, exchange 
of shares, change in corporate structure or otherwise), the Plan and 
outstanding options will be appropriately adjusted in the class(es) and 
maximum number of shares subject 

                                        8.

<PAGE>


to the Plan and the class(es) and number of shares and price per share of 
stock subject to outstanding options.

     (b)  In the event of:  (i) a merger or consolidation in which the 
Company is not the surviving corporation; (ii) a reverse merger in which the 
Company is the surviving corporation but the shares of the Company's common 
stock outstanding immediately preceding the merger are converted by virtue of 
the merger into other property, whether in the form of securities, cash or 
otherwise; or (iii) any other capital reorganization in which more than fifty 
percent (50%) of the shares of the Company entitled to vote are exchanged, 
then the time during which outstanding options may be exercised shall be 
accelerated to permit the optionee to exercise all such options prior to such 
merger, consolidation, reverse merger or reorganization, and the options 
shall terminate if not exercised prior to such event.

11.  AMENDMENT OF THE PLAN

     (a)  The Board at any time, and from time to time, may amend the Plan. 
However, except as provided in paragraph 10 relating to adjustments upon 
changes in stock, no amendment shall be effective unless approved by the 
stockholders of the Company within twelve (12) months before or after the 
adoption of the amendment, where the amendment will:

          (i)   Increase the number of shares which may be issued under the 
Plan;

          (ii)  Modify the requirements as to eligibility for participation 
in the Plan (to the extent such modification requires stockholder approval in 
order for the Plan to comply with the requirements of Rule 16b-3); or

          (iii) Modify the Plan in any other way if such modification 
requires stockholder approval in order for the Plan to comply with the 
requirements of Rule 16b-3.

                                        9.

<PAGE>

     (b)  Rights and obligations under any option granted before any amendment
of the Plan shall not be altered or impaired by such amendment unless (i) the
Company requests the consent of the person to whom the option was granted and
(ii) such person consents in writing.

12.  TERMINATION OR SUSPENSION OF THE PLAN

     (a)  The Board may suspend or terminate the Plan at any time.  Unless 
sooner terminated, the Plan shall terminate on December 31, 1999.  No options 
may be granted under the Plan while the Plan is suspended or after it is 
terminated.

     (b)  Rights and obligations under any option granted while the Plan is 
in effect shall not be altered or impaired by suspension or termination of 
the Plan, except with the consent of the person to whom the option was 
granted.

     (c)  The Plan shall terminate upon the occurrence of any of the events 
described in paragraph 10(b) above.

13.  EFFECTIVE DATE OF PLAN; CONDITIONS OF EXERCISE

     (a)  The Plan shall become effective upon adoption by the Board of 
Directors, subject to the condition subsequent that the Plan is approved by 
the stockholders of the Company.

     (b)  No option granted under the Plan shall be exercised or exercisable 
unless and until the condition of subparagraph 13(a) above has been met.

                                        10.

<PAGE>
                                 COCENSYS, INC.

                           1996 EQUITY INCENTIVE PLAN

                            ADOPTED DECEMBER 16, 1996
                 APPROVED BY STOCKHOLDERS ______________, 199__


1.   PURPOSES.

     (a)  The purpose of the Plan is to provide a means by which selected 
Employees and Directors of and Consultants to the Company and its Affiliates 
may be given an opportunity to benefit from increases in value of the common 
stock of the Company ("Common Stock") through the granting of (i) Incentive 
Stock Options, (ii) Nonstatutory Stock Options, (iii) stock bonuses and (iv) 
rights to purchase restricted stock, and (v) Stock Appreciation Rights, all 
as defined below.

     (b)  The Company, by means of the Plan, seeks to retain the services of 
persons who are now Employees, Directors or Consultants, to secure and retain 
the services of new Employees, Directors and Consultants, and to provide 
incentives for such persons to exert maximum efforts for the success of the 
Company and its Affiliates.

     (c)  The Company intends that the Stock Awards issued under the Plan 
shall, in the discretion of the Board or any Committee to which 
responsibility for administration of the Plan has been delegated pursuant to 
subsection 3(c), be either (i) Options granted pursuant to Section 6 hereof, 
including Incentive Stock Options and Nonstatutory Stock Options, or (ii) 
stock bonuses or rights to purchase restricted stock granted pursuant to 
Section 7 hereof, or (iii) Stock Appreciation Rights granted pursuant to 
Section 8 hereof.  All Options shall be separately designated Incentive Stock 
Options or Nonstatutory Stock Options at the time of grant, and a separate 
certificate or certificates will be issued for shares purchased on exercise 
of each type of Option.

2.   DEFINITIONS.

     (a)  "AFFILIATE" means any parent corporation or subsidiary corporation, 
whether now or hereafter existing, as those terms are defined in Sections 
424(e) and (f) respectively, of the Code.

     (b)  "BOARD" means the Board of Directors of the Company.

     (c)  "CODE" means the Internal Revenue Code of 1986, as amended.

     (d)  "COMMITTEE" means a Committee appointed by the Board in accordance 
with subsection 3(c) of the Plan.

     (e)  "COMPANY" means CoCensys, Inc., a Delaware corporation.


                                        1.

<PAGE>


     (f)  "CONCURRENT STOCK APPRECIATION RIGHT" OR "CONCURRENT RIGHT" means a 
right granted pursuant to subsection 8(b)(2) of the Plan.

     (g)  "CONSULTANT" means any person, including an advisor, engaged by the 
Company or an Affiliate to render consulting services and who is compensated 
for such services, provided that the term "Consultant" shall not include 
Directors who are paid only a director's fee by the Company or who are not 
compensated by the Company for their services as Directors.

     (h)  "CONTINUOUS STATUS AS AN EMPLOYEE, DIRECTOR OR CONSULTANT" means 
the employment or relationship as a Director or Consultant is not interrupted 
or terminated.  The Board, in its sole discretion, may determine whether 
Continuous Status as an Employee, Director or Consultant shall be considered 
interrupted in the case of:  (i) any leave of absence approved by the Board, 
including sick leave, military leave, or any other personal leave; or (ii) 
transfers between locations of the Company or between the Company, Affiliates 
or their successors.

     (i)  "DIRECTOR" means a member of the Board.

     (j)  "EMPLOYEE" means any person, including Officers and Directors, 
employed by the Company or any Affiliate of the Company.  Neither service as 
a Director nor payment of a director's fee by the Company shall be sufficient 
to constitute "employment" by the Company.

     (k)  "EXCHANGE ACT" means the Securities Exchange Act of 1934, as 
amended.

     (l)  "FAIR MARKET VALUE" means, as of any date, the value of the Common 
Stock of the Company determined as follows:

          (1)  If the Common Stock is listed on any established stock 
exchange, or traded on the Nasdaq National Market or The Nasdaq SmallCap 
Market, the Fair Market Value of a share of Common Stock shall be the closing 
sales price for such stock (or the closing bid, if no sales were reported) as 
quoted on such exchange or market (or the exchange or market with the 
greatest volume of trading in Common Stock) on the last market trading day 
prior to the day of determination, as reported in the Wall Street Journal or 
such other source as the Board deems reliable;

          (2)  In the absence of such markets for the Common Stock, the Fair 
Market Value shall be determined in good faith by the Board.

     (m)  "INCENTIVE STOCK OPTION" means an Option intended to qualify as an 
incentive stock option within the meaning of Section 422 of the Code and the 
regulations promulgated thereunder.

     (n)  "INDEPENDENT STOCK APPRECIATION RIGHT" means a right granted 
pursuant to subsection 8(b)(3) of the Plan.

                                        2.

<PAGE>

     (o)  "NON-EMPLOYEE DIRECTOR" means a Director who either (i) is not a 
current Employee or Officer of the Company or its parent or subsidiary, does 
not receive compensation (directly or indirectly) from the Company or its 
parent or subsidiary for services rendered as a consultant or in any capacity 
other than as a Director (except for an amount as to which disclosure would 
not be required under Item 404(a) of Regulation S-K promulgated pursuant to 
the Securities Act of 1933 ("Regulation S-K"), does not possess an interest 
in any other transaction as to which disclosure would be required under Item 
404(a) of Regulation S-K, and is not engaged in a business relationship as to 
which disclosure would be required under Item 404(b) of Regulation S-K; or 
(ii) is otherwise considered a "non-employee director" for purposes of Rule 
16b-3.

     (p)  "NONSTATUTORY STOCK OPTION" means an Option not intended to qualify 
as an Incentive Stock Option.

     (q)  "OFFICER" means a person who is an officer of the Company within 
the meaning of Section 16 of the Exchange Act and the rules and regulations 
promulgated thereunder.

     (r)  "OPTION" means a stock option granted pursuant to the Plan.

     (s)  "OPTION AGREEMENT" means a written agreement between the Company 
and an Optionee evidencing the terms and conditions of an individual Option 
grant. Each Option Agreement shall be subject to the terms and conditions of 
the Plan.

     (t)  "OPTIONEE" means a person to whom an Option is granted pursuant to 
the Plan.

     (u)  "OUTSIDE DIRECTOR" means a Director who either (i) is not a current 
employee of the Company or an "affiliated corporation" (within the meaning of 
Treasury regulations promulgated under Section 162(m) of the Code), is not a 
former employee of the Company or an "affiliated corporation" receiving 
compensation for prior services (other than benefits under a tax qualified 
pension plan), was not an officer of the Company or an "affiliated 
corporation" at any time, and is not currently receiving direct or indirect 
remuneration from the Company or an "affiliated corporation" for services in 
any capacity other than as a Director, or (ii) is otherwise considered an 
"outside director" for purposes of Section 162(m) of the Code.

     (v)  "PLAN" means this 1996 Equity Incentive Plan.

     (w)  "RULE 16b-3" means Rule 16b-3 of the Exchange Act or any successor 
to Rule 16b-3, as in effect when discretion is being exercised with respect 
to the Plan.

     (x)  "STOCK APPRECIATION RIGHT" means any of the various types of rights 
which may be granted under Section 8 of the Plan.

     (y)  "STOCK AWARD" means any right granted under the Plan, including any 
Option, any stock bonus, and any right to purchase restricted stock.

                                        3.

<PAGE>


     (z)  "STOCK AWARD AGREEMENT" means a written agreement between the 
Company and a holder of a Stock Award evidencing the terms and conditions of 
an individual Stock Award grant.  Each Stock Award Agreement shall be subject 
to the terms and conditions of the Plan.

     (aa) "TANDEM STOCK APPRECIATION RIGHT" OR "TANDEM RIGHT" means a right 
granted pursuant to subsection 8(b)(1) of the Plan.

3.   ADMINISTRATION.

     (a)  The Plan shall be administered by the Board unless and until the 
Board delegates administration to a Committee, as provided in subsection 3(c).

     (b)  The Board shall have the power, subject to, and within the 
limitations of, the express provisions of the Plan:

          (1)  To determine from time to time which of the persons eligible 
under the Plan shall be granted Stock Awards; when and how each Stock Award 
shall be granted; whether a Stock Award will be an Incentive Stock Option, a 
Nonstatutory Stock Option, a stock bonus, a right to purchase restricted 
stock, a Stock Appreciation Right, or a combination of the foregoing; the 
provisions of each Stock Award granted (which need not be identical), 
including the time or times when a person shall be permitted to receive stock 
pursuant to a Stock Award; whether a person shall be permitted to receive 
stock upon exercise of an Independent Stock Appreciation Right; and the 
number of shares with respect to which a Stock Award shall be granted to each 
such person.

          (2)  To construe and interpret the Plan and Stock Awards granted 
under it, and to establish, amend and revoke rules and regulations for its 
administration.  The Board, in the exercise of this power, may correct any 
defect, omission or inconsistency in the Plan or in any Stock Award 
Agreement, in a manner and to the extent it shall deem necessary or expedient 
to make the Plan fully effective.

          (3)  To amend the Plan or a Stock Award as provided in Section 14.

          (4)  Generally, to exercise such powers and to perform such acts as 
the Board deems necessary or expedient to promote the best interests of the 
Company which are not in conflict with the provisions of the Plan.

     (c)  The Board may delegate administration of the Plan to a committee or 
committees ("Committee") of one or more members of the Board.  In the 
discretion of the Board, a Committee may consist solely of two (2) or more 
Outside Directors, in accordance with Code Section 162(m), or solely of two 
(2) or more Non-Employee Directors, in accordance with Rule 16b-3.  If 
administration is delegated to a Committee, the Committee shall have, in 
connection with the administration of the Plan, the powers theretofore 
possessed by the Board (and references in this Plan to the Board shall 
thereafter be to the Committee), subject, however, to such resolutions, not 
inconsistent with the provisions of the Plan, as may be adopted from time 

                                        4.

<PAGE>


to time by the Board.  The Board may abolish the Committee at any time and 
revest in the Board the administration of the Plan.

4.   SHARES SUBJECT TO THE PLAN.

     (a)  Subject to the provisions of Section 13 relating to adjustments 
upon changes in stock, the stock that may be issued pursuant to Stock Awards 
shall not exceed in the aggregate two million eight hundred thousand 
(2,800,000) shares of Common Stock.  If any Stock Award shall for any reason 
expire or otherwise terminate, in whole or in part, without having been 
exercised in full (or vested in the case of Restricted Stock), the stock not 
acquired under such Stock Award shall revert to and again become available 
for issuance under the Plan.  Shares subject to Stock Appreciation Rights 
exercised in accordance with Section 8 of the Plan shall not be available for 
subsequent issuance under the Plan.

     (b)  The stock subject to the Plan may be unissued shares or reacquired 
shares, bought on the market or otherwise.

5.   ELIGIBILITY.

     (a)  Incentive Stock Options and Stock Appreciation Rights appurtenant 
thereto may be granted only to Employees.  Stock Awards other than Incentive 
Stock Options and Stock Appreciation Rights appurtenant thereto may be 
granted only to Employees, Directors or Consultants.

     (b)  No person shall be eligible for the grant of an Incentive Stock 
Option if, at the time of grant, such person owns (or is deemed to own 
pursuant to Section 424(d) of the Code) stock possessing more than ten 
percent (10%) of the total combined voting power of all classes of stock of 
the Company or of any of its Affiliates unless the exercise price of such 
Option is at least one hundred ten percent (110%) of the Fair Market Value of 
such stock at the date of grant and the Option is not exercisable after the 
expiration of five (5) years from the date of grant.

     (c)  Subject to the provisions of Section 13 relating to adjustments 
upon changes in stock, no person shall be eligible to be granted Options and 
Stock Appreciation Rights covering more than five hundred thousand (500,000) 
shares of Common Stock in any calendar year.

6.   OPTION PROVISIONS.

     Each Option shall be in such form and shall contain such terms and 
conditions as the Board shall deem appropriate.  The provisions of separate 
Options need not be identical, but each Option shall include (through 
incorporation of provisions hereof by reference in the Option or otherwise) 
the substance of each of the following provisions:

     (a)  TERM.  No Option shall be exercisable after the expiration of ten 
(10) years from the date it was granted.

                                        5.

<PAGE>


     (b)  PRICE.  The exercise price of each Incentive Stock Option shall be 
not less than one hundred percent (100%) of the Fair Market Value of the 
stock subject to the Option on the date the Option is granted, and the 
exercise price of each Nonstatutory Stock Option shall be not less than 
eighty-five percent (85%) of the Fair Market Value of the stock subject to 
the Option on the date the Option is granted.  Notwithstanding the foregoing, 
an Option may be granted with an exercise price lower than that set forth in 
the preceding sentence if such Option is granted pursuant to an assumption or 
substitution for another option in a manner satisfying the provisions of 
Section 424(a) of the Code.

     (c)  CONSIDERATION.  The purchase price of stock acquired pursuant to an 
Option shall be paid, to the extent permitted by applicable statutes and 
regulations, either (i) in cash at the time the Option is exercised, or (ii) 
at the discretion of the Board or Committee, at the time of the grant of the 
Option, (A) by delivery to the Company of other Common Stock of the Company, 
(B) according to a deferred payment or other arrangement (which may include, 
without limiting the generality of the foregoing, the use of other Common 
Stock of the Company) with the person to whom the Option is granted or to 
whom the Option is transferred pursuant to subsection 6(d), or (C) in any 
other form of legal consideration that may be acceptable to the Board.  In 
the case of any deferred payment arrangement, interest shall be payable at 
least annually and shall be charged at the minimum rate of interest necessary 
to avoid the treatment as interest, under any applicable provisions of the 
Code, of any amounts other than amounts stated to be interest under the 
deferred payment arrangement.

     (d)  TRANSFERABILITY.  An Incentive Stock Option shall not be 
transferable except by will or by the laws of descent and distribution, and 
shall be exercisable during the lifetime of the person to whom the Incentive 
Stock Option is granted only by such person.  A Nonstatutory Stock Option may 
be transferred to the extent provided in the Option Agreement; provided that 
if the Option Agreement does not expressly permit the transfer of a 
Nonstatutory Stock Option, the Nonstatutory Stock Option shall not be 
transferable except by will, by the laws of descent and distribution or 
pursuant to a domestic relations order satisfying the requirements of Rule 
16b-3, and shall be exercisable during the lifetime of the person to whom the 
Option is granted only by such person or any transferee pursuant to a 
domestic relations order.  Notwithstanding the foregoing, the person to whom 
the Option is granted may, by delivering written notice to the Company, in a 
form satisfactory to the Company, designate a third party who, in the event 
of the death of the Optionee, shall thereafter be entitled to exercise the 
Option.

     (e)  VESTING.  The total number of shares of stock subject to an Option 
may, but need not, be allotted in periodic installments (which may, but need 
not, be equal).  The Option Agreement may provide that from time to time 
during each of such installment periods, the Option may become exercisable 
("vest") with respect to some or all of the shares allotted to that period, 
and may be exercised with respect to some or all of the shares allotted to 
such period and/or any prior period as to which the Option became vested but 
was not fully exercised.  The Option may be subject to such other terms and 
conditions on the time or times when it may be exercised (which may be based 
on performance or other criteria) as the Board may deem appropriate.  The 
provisions of this subsection 6(e) are subject to any Option provisions 
governing the minimum number of shares as to which an Option may be exercised.


                                        6.

<PAGE>


     (f)  TERMINATION OF EMPLOYMENT OR RELATIONSHIP AS A DIRECTOR OR 
CONSULTANT. In the event an Optionee's Continuous Status as an Employee, 
Director or Consultant terminates (other than upon the Optionee's death or 
disability), the Optionee may exercise his or her Option within such period 
of time designated by the Board, which shall in no event be later than the 
expiration of the term of the Option as set forth in the Option Agreement 
(the "Post-Termination Exercise Period") and only to the extent that the 
Optionee was entitled to exercise the Option on the date Optionee's 
Continuous Status as an Employee, Director or Consultant terminates. In the 
case of an Incentive Stock Option, the Board shall determine the 
Post-Termination Exercise Period at the time the Option is granted, and the 
term of such Post-Termination Exercise Period shall in no event exceed three 
(3) months from the date of termination.  In addition, the Board may at any 
time, with the consent of the Optionee, extend the Post-Termination Exercise 
Period and provide for continued vesting; provided however, that any 
extension of such period by the Board in excess of three (3) months from the 
date of termination shall cause an Incentive Stock Option so extended to 
become a Nonstatutory Stock Option, effective as of the date of Board action. 
If, at the date of termination, the Optionee is not entitled to exercise his 
or her entire Option, the shares covered by the unexercisable portion of the 
Option shall revert to the Plan.  If, after termination, the Optionee does 
not exercise his or her Option within the time specified in the Option 
Agreement or as otherwise determined above, the Option shall terminate, and 
the shares covered by such Option shall revert to the Plan.  Notwithstanding 
the foregoing, the Board shall have the power to permit an Option to continue 
to vest during the Post-Termination Exercise Period.

     (g)  DISABILITY OF OPTIONEE.  In the event an Optionee's Continuous 
Status as an Employee, Director or Consultant terminates as a result of the 
Optionee's disability, the Optionee may exercise his or her Option (to the 
extent that the Optionee was entitled to exercise it at the date of 
termination), but only within such period of time ending on the earlier of 
(i) the date twelve (12) months following such termination (or such longer or 
shorter period specified in the Option Agreement), or (ii) the expiration of 
the term of the Option as set forth in the Option Agreement.  If, at the date 
of termination, the Optionee is not entitled to exercise his or her entire 
Option, the shares covered by the unexercisable portion of the Option shall 
revert to and again become available for issuance under the Plan.  If, after 
termination, the Optionee does not exercise his or her Option within the time 
specified herein, the Option shall terminate, and the shares covered by such 
Option shall revert to and again become available for issuance under the Plan.

     (h)  DEATH OF OPTIONEE.  In the event of the death of an Optionee 
during, or within a three (3)-month period after the termination of, the 
Optionee's Continuous Status as an Employee, Director or Consultant, the 
Option may be exercised to the extent vested by the Optionee's estate, by a 
person who acquired the right to exercise the Option by bequest or 
inheritance or by a person designated to exercise the option upon the 
Optionee's death pursuant to subsection 6(d), but only within the period 
ending on the earlier of (i) the date twelve (12) months following the date 
of death (or such longer or shorter period specified in the Option 
Agreement), or (ii) the expiration of the term of such Option as set forth in 
the Option Agreement.  If, at the time of death, the Optionee was not 
entitled to exercise his or her entire Option, the shares covered by the 
unexercisable portion of the Option shall revert to and again become 
available for issuance under the Plan.  If, after death, the Option is not 
exercised within 


                                        7.

<PAGE>


the time specified herein, the Option shall terminate, and the shares covered 
by such Option shall revert to and again become available for issuance under 
the Plan.

     (i)  EARLY EXERCISE.  The Option may, but need not, include a provision 
whereby the Optionee may elect at any time while an Employee, Director or 
Consultant to exercise the Option as to any part or all of the shares subject 
to the Option prior to the full vesting of the Option.  Any unvested shares 
so purchased may be subject to a repurchase right in favor of the Company or 
to any other restriction the Board determines to be appropriate.

     (j)  RE-LOAD OPTIONS.  Without in any way limiting the authority of the 
Board or Committee to make or not to make grants of Options hereunder, the 
Board or Committee shall have the authority (but not an obligation) to 
include as part of any Option Agreement a provision entitling the Optionee to 
a further Option (a "Re-Load Option") in the event the Optionee exercises the 
Option evidenced by the Option Agreement, in whole or in part, by 
surrendering other shares of Common Stock in accordance with this Plan and 
the terms and conditions of the Option Agreement.  Any such Re-Load Option 
(i) shall be for a number of shares equal to the number of shares surrendered 
as part or all of the exercise price of such Option; (ii) shall have an 
expiration date which is the same as the expiration date of the Option the 
exercise of which gave rise to such Re-Load Option; and (iii) shall have an 
exercise price which is equal to one hundred percent (100%) of the Fair 
Market Value of the Common Stock subject to the Re-Load Option on the date of 
exercise of the original Option.  Notwithstanding the foregoing, a Re-Load 
Option which is an Incentive Stock Option and which is granted to a 10% 
stockholder (as described in subsection 5(b)), shall have an exercise price 
which is equal to one hundred ten percent (110%) of the Fair Market Value of 
the stock subject to the Re-Load Option on the date of exercise of the 
original Option and shall have a term which is no longer than five (5) years.

     Any such Re-Load Option may be an Incentive Stock Option or a 
Nonstatutory Stock Option, as the Board or Committee may designate at the 
time of the grant of the original Option; PROVIDED, HOWEVER, that the 
designation of any Re-Load Option as an Incentive Stock Option shall be 
subject to the one hundred thousand dollars ($100,000) annual limitation on 
exercisability of Incentive Stock Options described in subsection 12(d) of 
the Plan and in Section 422(d) of the Code.  There shall be no Re-Load 
Options on a Re-Load Option.  Any such Re-Load Option shall be subject to the 
availability of sufficient shares under subsection 4(a) and shall be subject 
to such other terms and conditions as the Board or Committee may determine 
which are not inconsistent with the express provisions of the Plan regarding 
the terms of Options.

7.   TERMS OF STOCK BONUSES AND PURCHASES OF RESTRICTED STOCK.

     Each stock bonus or restricted stock purchase agreement shall be in such 
form and shall contain such terms and conditions as the Board or Committee 
shall deem appropriate.  The terms and conditions of stock bonus or 
restricted stock purchase agreements may change from time to time, and the 
terms and conditions of separate agreements need not be identical, but each 
stock bonus or restricted stock purchase agreement shall include (through 
incorporation of provisions hereof by reference in the agreement or 
otherwise) the substance of each of the following provisions as appropriate:


                                        8.

<PAGE>


     (a)  PURCHASE PRICE.  The purchase price under each restricted stock 
purchase agreement shall be such amount as the Board or Committee shall 
determine and designate in such agreement but in no event shall the purchase 
price be less than eighty-five percent (85%) of the stock's Fair Market Value 
on the date such award is made.  Notwithstanding the foregoing, the Board or 
Committee may determine that eligible participants in the Plan may be awarded 
stock pursuant to a stock bonus agreement in consideration for past services 
actually rendered to the Company for its benefit.

     (b)  TRANSFERABILITY.  No rights under a stock bonus or restricted stock 
purchase agreement shall be transferable except by will or the laws of 
descent and distribution or, if the agreement so provides, pursuant to a 
domestic relations order satisfying the requirements of Rule 16b-3, so long 
as stock awarded under such agreement remains subject to the terms of the 
agreement.

     (c)  CONSIDERATION.  The purchase price of stock acquired pursuant to a 
stock purchase agreement shall be paid either:  (i) in cash at the time of 
purchase; (ii) at the discretion of the Board or Committee, according to a 
deferred payment or other arrangement with the person to whom the stock is 
sold; or (iii) in any other form of legal consideration that may be 
acceptable to the Board or Committee in its discretion.  Notwithstanding the 
foregoing, the Board or Committee to which administration of the Plan has 
been delegated may award stock pursuant to a stock bonus agreement in 
consideration for past services actually rendered to the Company or for its 
benefit.

     (d)  VESTING.  Shares of stock sold or awarded under the Plan may, but 
need not, be subject to a repurchase option in favor of the Company in 
accordance with a vesting schedule to be determined by the Board or Committee.

     (e)  TERMINATION OF CONTINUOUS STATUS AS AN EMPLOYEE, DIRECTOR OR 
CONSULTANT.  In the event a Participant's Continuous Status as an Employee, 
Director or Consultant terminates, the Company may repurchase or otherwise 
reacquire any or all of the shares of stock held by that person which have 
not vested as of the date of termination under the terms of the stock bonus 
or restricted stock purchase agreement between the Company and such person.

8.   STOCK APPRECIATION RIGHTS.

     (a)  The Board or Committee shall have full power and authority, 
exercisable in its sole discretion, to grant Stock Appreciation Rights under 
the Plan to Employees, Directors and Consultants.  To exercise any 
outstanding Stock Appreciation Right, the holder must provide written notice 
of exercise to the Company in compliance with the provisions of the Stock 
Award Agreement evidencing such right.  Except as provided in subsection 
5(c), no limitation shall exist on the aggregate amount of cash payments the 
Company may make under the Plan in connection with the exercise of a Stock 
Appreciation Right.

     (b)  Three types of Stock Appreciation Rights shall be authorized for 
issuance under the Plan:


                                        9.

<PAGE>


          (1)  TANDEM STOCK APPRECIATION RIGHTS.  Tandem Stock Appreciation 
Rights will be granted appurtenant to an Option, and shall, except as 
specifically set forth in this Section 8, be subject to the same terms and 
conditions applicable to the particular Option grant to which it pertains. 
Tandem Stock Appreciation Rights will require the holder to elect between the 
exercise of the underlying Option for shares of stock and the surrender, in 
whole or in part, of such Option for an appreciation distribution.  The 
appreciation distribution payable on the exercised Tandem Right shall be in 
cash (or, if so provided, in an equivalent number of shares of stock based on 
Fair Market Value on the date of the Option surrender) in an amount up to the 
excess of (A) the Fair Market Value (on the date of the Option surrender) of 
the number of shares of stock covered by that portion of the surrendered 
Option in which the Optionee is vested over (B) the aggregate exercise price 
payable for such vested shares.

          (2)  CONCURRENT STOCK APPRECIATION RIGHTS.  Concurrent Rights will 
be granted appurtenant to an Option and may apply to all or any portion of 
the shares of stock subject to the underlying Option and shall, except as 
specifically set forth in this Section 8, be subject to the same terms and 
conditions applicable to the particular Option grant to which it pertains.  A 
Concurrent Right shall be exercised automatically at the same time the 
underlying Option is exercised with respect to the particular shares of stock 
to which the Concurrent Right pertains.  The appreciation distribution 
payable on an exercised Concurrent Right shall be in cash (or, if so 
provided, in an equivalent number of shares of stock based on Fair Market 
Value on the date of the exercise of the Concurrent Right) in an amount equal 
to such portion as shall be determined by the Board or Committee at the time 
of the grant of the excess of (A) the aggregate Fair Market Value (on the 
date of the exercise of the Concurrent Right) of the vested shares of stock 
purchased under the underlying Option which have Concurrent Rights 
appurtenant to them over (B) the aggregate exercise price paid for such 
shares.

          (3)  INDEPENDENT STOCK APPRECIATION RIGHTS.  Independent Rights 
will be granted independently of any Option and shall, except as specifically 
set forth in this Section 8, be subject to the same terms and conditions 
applicable to Nonstatutory Stock Options as set forth in Section 6.  They 
shall be denominated in share equivalents.  The appreciation distribution 
payable on the exercised Independent Right shall be not greater than an 
amount equal to the excess of (A) the aggregate Fair Market Value (on the 
date of the exercise of the Independent Right) of a number of shares of 
Company stock equal to the number of share equivalents in which the holder is 
vested under such Independent Right, and with respect to which the holder is 
exercising the Independent Right on such date, over (B) the aggregate Fair 
Market Value (on the date of the grant of the Independent Right) of such 
number of shares of Company stock.  The appreciation distribution payable on 
the exercised Independent Right shall be in cash or, if so provided, in an 
equivalent number of shares of stock based on Fair Market Value on the date 
of the exercise of the Independent Right.

9.   CANCELLATION AND RE-GRANT OF OPTIONS.

     (a)  The Board or Committee shall have the authority to effect, at any 
time and from time to time,  (i) the repricing of any outstanding Options 
and/or any Stock Appreciation Rights under the Plan and/or (ii) with the 
consent of any adversely affected holders of Options and/or Stock 


                                        10.

<PAGE>

Appreciation Rights, the cancellation of any outstanding Options and/or any 
Stock Appreciation Rights under the Plan and the grant in substitution 
therefor of new Options and/or Stock Appreciation Rights under the Plan 
covering the same or different numbers of shares of stock, but having an 
exercise price per share not less than: eighty-five percent (85%) of the Fair 
Market Value for a Nonstatutory Stock Option, one hundred percent (100%) of 
the Fair Market Value in the case of an Incentive Stock Option or, in the 
case of an Incentive Stock Option held by a 10% stockholder (as described in 
subsection 5(b)), not less than one hundred ten percent (110%) of the Fair 
Market Value per share of stock on the new grant date.  Notwithstanding the 
foregoing, the Board or Committee may grant an Option and/or Stock 
Appreciation Right with an exercise price lower than that set forth above if 
such Option and/or Stock Appreciation Right is granted as part of a 
transaction to which section 424(a) of the Code applies.

     (b)  Shares subject to an Option or Stock Appreciation Right canceled 
under this Section 9 shall continue to be counted against the maximum award 
of Options and Stock Appreciation Rights permitted to be granted pursuant to 
the Plan.  The repricing of an Option and/or Stock Appreciation Right 
hereunder resulting in a reduction of the exercise price, shall be deemed to 
be a cancellation of the original Option and/or Stock Appreciation Right and 
the grant of a substitute Option and/or Stock Appreciation Right; in the 
event of such repricing, both the original and the substituted Options and 
Stock Appreciation Rights shall be counted against the maximum awards of 
Options and Stock Appreciation Rights permitted to be granted pursuant to the 
Plan, to the extent required by Section 162(m) of the Code.

10.  COVENANTS OF THE COMPANY.

     (a)  During the terms of the Stock Awards, the Company shall keep 
available at all times the number of shares of stock required to satisfy such 
Stock Awards.

     (b)  The Company shall seek to obtain from each regulatory commission or 
agency having jurisdiction over the Plan such authority as may be required to 
issue and sell shares under Stock Awards; provided, however, that this 
undertaking shall not require the Company to register under the Securities 
Act of 1933, as amended (the "Securities Act") either the Plan, any Stock 
Award or any stock issued or issuable pursuant to any such Stock Award.  If, 
after reasonable efforts, the Company is unable to obtain from any such 
regulatory commission or agency the authority which counsel for the Company 
deems necessary for the lawful issuance and sale of stock under the Plan, the 
Company shall be relieved from any liability for failure to issue and sell 
stock upon exercise of such Stock Awards unless and until such authority is 
obtained.

11.  USE OF PROCEEDS FROM STOCK.

     Proceeds from the sale of stock pursuant to Stock Awards shall 
constitute general funds of the Company.

12.  MISCELLANEOUS.

     (a)  The Board shall have the power to accelerate the time at which a 
Stock Award may first be exercised or the time during which a Stock Award or 
any part thereof will vest, 


                                        11.

<PAGE>

notwithstanding the provisions in the Stock Award stating the time at which 
it may first be exercised or the time during which it will vest.

     (b)  Neither an Employee, Director nor a Consultant nor any person to 
whom a Stock Award is transferred in accordance with the Plan shall be deemed 
to be the holder of, or to have any of the rights of a holder with respect 
to, any shares subject to such Stock Award unless and until such person has 
satisfied all requirements for exercise of the Stock Award pursuant to its 
terms.

     (c)  Nothing in the Plan or any instrument executed or Stock Award 
granted pursuant thereto shall confer upon any Employee, Consultant or other 
holder of Stock Awards any right to continue in the employ of the Company or 
any Affiliate, or to continue serving as a Consultant and Director, or shall 
affect the right of the Company or any Affiliate to terminate the employment 
of any Employee with or without notice and with or without cause, or the 
right to terminate the relationship of any Consultant pursuant to the terms 
of such Consultant's agreement with the Company or Affiliate or service as a 
Director pursuant to the Company's By-Laws.

     (d)  To the extent that the aggregate Fair Market Value (determined at 
the time of grant) of stock with respect to which Incentive Stock Options are 
exercisable for the first time by any Optionee during any calendar year under 
all plans of the Company and its Affiliates exceeds one hundred thousand 
dollars ($100,000), the Options or portions thereof which exceed such limit 
(according to the order in which they were granted) shall be treated as 
Nonstatutory Stock Options.

     (e)  The Company may require any person to whom a Stock Award is 
granted, or any person to whom a Stock Award is transferred in accordance 
with the Plan, as a condition of exercising or acquiring stock under any 
Stock Award, (1) to give written assurances satisfactory to the Company as to 
such person's knowledge and experience in financial and business matters 
and/or to employ a purchaser representative reasonably satisfactory to the 
Company who is knowledgeable and experienced in financial and business 
matters, and that he or she is capable of evaluating, alone or together with 
the purchaser representative, the merits and risks of exercising the Stock 
Award; and (2) to give written assurances satisfactory to the Company stating 
that such person is acquiring the stock subject to the Stock Award for such 
person's own account and not with any present intention of selling or 
otherwise distributing the stock. The foregoing requirements, and any 
assurances given pursuant to such requirements, shall be inoperative if (i) 
the issuance of the shares upon the exercise or acquisition of stock under 
the Stock Award has been registered under a then currently effective 
registration statement under the Securities Act, or (ii) as to any particular 
requirement, a determination is made by counsel for the Company that such 
requirement need not be met in the circumstances under the then applicable 
securities laws.  The Company may, upon advice of counsel to the Company, 
place legends on stock certificates issued under the Plan as such counsel 
deems necessary or appropriate in order to comply with applicable securities 
laws, including, but not limited to, legends restricting the transfer of the 
stock.

                                        12.

<PAGE>


     (f)  To the extent provided by the terms of a Stock Award Agreement, the 
person to whom a Stock Award is granted may satisfy any federal, state or 
local tax withholding obligation relating to the exercise or acquisition of 
stock under a Stock Award by any of the following means or by a combination 
of such means:  (1) tendering a cash payment; (2) authorizing the Company to 
withhold shares from the shares of the Common Stock otherwise issuable to the 
participant as a result of the exercise or acquisition of stock under the 
Stock Award; or (3) delivering to the Company owned and unencumbered shares 
of the Common Stock of the Company.

13.  ADJUSTMENTS UPON CHANGES IN STOCK.

     (a)  If any change is made in the stock subject to the Plan, or subject 
to any Stock Award, without the receipt of consideration by the Company 
(through merger, consolidation, reorganization, recapitalization, 
reincorporation, stock dividend, dividend in property other than cash, stock 
split, liquidating dividend, combination of shares, exchange of shares, 
change in corporate structure or other transaction not involving the receipt 
of consideration by the Company), the Plan will be appropriately adjusted in 
the class(es) and maximum number of shares subject to the Plan and the 
maximum number of shares subject to award to any person during any calendar 
year, and the outstanding Stock Awards will be appropriately adjusted in the 
class(es) and number of shares and price per share of stock subject to such 
outstanding Stock Awards.  Such adjustments shall be made by the Board or 
Committee, the determination of which shall be final, binding and conclusive. 
(The conversion of any convertible securities of the Company shall not be 
treated as a "transaction not involving the receipt of consideration by the 
Company.")

     (b)  In the event of:  (1) a dissolution, liquidation or sale of 
substantially all of the assets of the Company; (2) a merger or consolidation 
in which the Company is not the surviving corporation; or (3) a reverse 
merger in which the Company is the surviving corporation but the shares of 
the Common Stock outstanding immediately preceding the merger are converted 
by virtue of the merger into other property, whether in the form of 
securities, cash or otherwise, then to the extent permitted by applicable 
law:  (i) any surviving corporation (or an Affiliate thereof shall assume any 
Stock Awards outstanding under the Plan or shall substitute similar Stock 
Awards for those outstanding under the Plan, or (ii) such Stock Awards shall 
continue in full force and effect.  In the event any surviving corporation 
(or an Affiliate) refuses to assume or continue such Stock Awards, or to 
substitute similar Stock Awards for those outstanding under the Plan, then, 
with respect to Stock Awards held by persons then performing services as 
Employees, Directors or Consultants, the time during which such Stock Awards 
may be exercised shall be accelerated and the Stock Awards terminated if not 
exercised prior to such event.

14.  AMENDMENT OF THE PLAN AND STOCK AWARDS.

     (a)  The Board at any time, and from time to time, may amend the Plan. 
However, except as provided in Section 13 relating to adjustments upon 
changes in stock, no amendment shall be effective unless approved by the 
stockholders of the Company to the extent stockholder 

                                        13.

<PAGE>


approval is necessary for the Plan to satisfy the requirements of Section 422 
of the Code, Rule 16b-3 or any Nasdaq or securities exchange listing 
requirements.

     (b)  The Board may in its sole discretion submit any other amendment to 
the Plan for stockholder approval, including, but not limited to, amendments 
to the Plan intended to satisfy the requirements of Section 162(m) of the 
Code and the regulations thereunder regarding the exclusion of 
performance-based compensation from the limit on corporate deductibility of 
compensation paid to certain executive officers.

     (c)  It is expressly contemplated that the Board may amend the Plan in 
any respect the Board deems necessary or advisable to provide eligible 
Employees, Directors or Consultants with the maximum benefits provided or to 
be provided under the provisions of the Code and the regulations promulgated 
thereunder relating to Incentive Stock Options and/or to bring the Plan 
and/or Incentive Stock Options granted under it into compliance therewith.

     (d)  Rights and obligations under any Stock Award granted before 
amendment of the Plan shall not be impaired by any amendment of the Plan 
unless (i) the Company requests the consent of the person to whom the Stock 
Award was granted and (ii) such person consents in writing.

     (e)  The Board at any time, and from time to time, may amend the terms 
of any one or more Stock Award; provided, however, that the rights and 
obligations under any Stock Award shall not be impaired by any such amendment 
unless (i) the Company requests the consent of the person to whom the Stock 
Award was granted and (ii) such person consents in writing.

15.  TERMINATION OR SUSPENSION OF THE PLAN.

     (a)  The Board may suspend or terminate the Plan at any time.  Unless 
sooner terminated, the Plan shall terminate ten (10) years from the date the 
Plan is adopted by the Board or approved by the stockholders of the Company, 
whichever is earlier.  No Stock Awards may be granted under the Plan while 
the Plan is suspended or after it is terminated.

     (b)  Rights and obligations under any Stock Award granted while the Plan 
is in effect shall not be impaired by suspension or termination of the Plan, 
except with the consent of the person to whom the Stock Award was granted.

16.  EFFECTIVE DATE OF PLAN.

     This Plan shall become effective on the date of adoption by the Board, 
but no Stock Awards granted under the Plan shall be exercised unless and 
until the Plan has been approved by the stockholders of the Company, which 
approval shall be within twelve (12) months before or after the date the Plan 
is adopted by the Board. 
                                        14.

<PAGE>

                                  COCENSYS, INC.

                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                                        
                           TO BE HELD ON JUNE 25, 1997


     The undersigned hereby appoints LOWELL E. SEARS and ALAN C. MENDELSON, 
and each of them, as attorneys and proxies of the undersigned, with full 
power of substitution, to vote all of the shares of stock of CoCensys, Inc. 
which the undersigned may be entitled to vote at the Annual Meeting of 
Stockholders of CoCensys, Inc. to be held at The Sutton Place Hotel, 4500 
MacArthur Boulevard, Newport Beach, California on Wednesday, June 25, 1997, 
at 2:00 p.m., local time, and at any and all continuations and adjournments 
thereof, with all powers that the undersigned would possess if personally 
present, upon and in respect of the following matters and in accordance with 
the following instructions, with discretionary authority as to any and all 
other matters that may properly come before the meeting.

     UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR 
ALL NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2, 3 AND 4 AS MORE 
SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT.  IF SPECIFIC INSTRUCTIONS ARE 
INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.

     MANAGEMENT RECOMMENDS A VOTE FOR THE NOMINEES FOR DIRECTOR LISTED BELOW.

PROPOSAL 1:         To elect two directors to hold office until the 2000 Annual
                    Meeting of Stockholders.

                                        
/ /            FOR all nominees           / /            WITHHOLD AUTHORITY to 
               listed below (except                      vote for all nominees 
               as marked to the                          listed below.         
               contrary below).


NOMINEES: F. Richard Nichol, Ph.D.      Timothy J. Rink, M.D.

TO WITHHOLD AUTHORITY TO VOTE FOR ANY NOMINEE(S), WRITE SUCH NOMINEE(S)' NAME(S)
BELOW:


- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------


                            (CONTINUED ON OTHER SIDE)

                                        1.

<PAGE>


                           (CONTINUED FROM OTHER SIDE)


MANAGEMENT RECOMMENDS A VOTE FOR PROPOSAL 2.

PROPOSAL 2:         To approve the amendment and restatement of the Company's
                    1992 Non-Employee Directors' Stock Option Plan, as amended,
                    to increase the annual option grants thereunder and to
                    conform the administrative provisions thereof to the 
                    amended rules applicable under Section 16 of the 
                    Securities and Exchange Act of 1934, as amended.

               / /   FOR           / /   AGAINST       / /   ABSTAIN


MANAGEMENT RECOMMENDS A VOTE FOR PROPOSAL 3.

PROPOSAL 3:         To approve the Company's 1996 Equity Incentive Plan and the
                    issuance of 2,800,000 shares of the Company's Common Stock
                    thereunder.

               / /   FOR           / /   AGAINST       / /   ABSTAIN



MANAGEMENT RECOMMENDS A VOTE FOR PROPOSAL 4.

PROPOSAL 4:         To ratify the selection of Ernst & Young LLP as independent
                    auditors of the Company for its fiscal year ending December
                    31, 1997.

               / /   FOR           / /   AGAINST       / /   ABSTAIN



                    (CONTINUED AND TO BE SIGNED ON NEXT PAGE)


                                        2.

<PAGE>


                             (CONTINUED FROM PAGE 2)



Dated               , 1997            --------------------------------------


                                      --------------------------------------
                                      SIGNATURE(S)

                                      PLEASE SIGN EXACTLY AS YOUR NAME 
                                      APPEARS HEREON. IF THE STOCK IS 
                                      REGISTERED IN THE NAMES OF TWO 
                                      OR MORE PERSONS, EACH SHOULD 
                                      SIGN.  EXECUTORS, ADMINISTRATORS,
                                      TRUSTEES, GUARDIANS AND 
                                      ATTORNEYS-IN-FACT SHOULD ADD THEIR 
                                      TITLES.  IF SIGNER IS A CORPORATION, 
                                      PLEASE GIVE FULL CORPORATE NAME AND 
                                      HAVE A DULY AUTHORIZED OFFICER 
                                      SIGN, STATING TITLE.  IF SIGNER 
                                      IS A PARTNERSHIP, PLEASE SIGN IN 
                                      PARTNERSHIP NAME BY AUTHORIZED 
                                      PERSON.

PLEASE VOTE, DATE AND PROMPTLY RETURN THIS PROXY IN THE ENCLOSED RETURN
ENVELOPE, WHICH IS POSTAGE PREPAID IF MAILED IN THE UNITED STATES.

                                        3.




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