COCENSYS INC
5, 1998-02-13
PHARMACEUTICAL PREPARATIONS
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FORM 5
                                                          OMB APPROVAL
                                               ---------------------------------
                                               OMB Number              3235-0362
                                               Expires:       September 30, 1998
                                               Estimated average burden
                                               hours per response........... 1.0

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

               ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

     Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

|_|Check box if no longer subject to
   Section 16.  Form 4 or Form 5 obli-
   gations may continue.  See Instruc-
   tion 1(b).
|_|Form 3 Holdings Reported
|_|Form 4 Transactions Reported

1.  Name and Address of Reporting Person*

    Novartis AG
    Schwarzwaldallee 215
    CH-4002 Basel, Switzerland

2.  Issuer Name and Ticker or Trading Symbol

    CoCensys, Inc. (COCN)

3. IRS or Social Security Number of Reporting Person (Voluntary)


4. Statement for Month/Year
      December 31, 1997

5. If Amendment, Date of Original (Month/Year)


6. Relationship of Reporting Person(s) to Issuer
   (Check all applicable)
   ___ Director                       _X_ 10% Owner
   ___ Officer (give title below)     ___ Other (specify below)
   _______________________________

7. Individual or Joint/Group Reporting
   (check applicable line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

 Table I--Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

<TABLE>
<CAPTION>
1.  Title of Security        2. Trans-  3. Transac- 4. Securities Acquired (A)      5. Amount of         6. Owner-    7. Nature of
    (Instr. 3)                  action     tion        or Disposed of (D)              Securities Bene-     ship         Indirect
                                Date       Code        (Instr. 3, 4 and 5)             ficially Owned       Form:        Beneficial
                                (Month/    (Instr.                                     at end of            Direct       Ownership
                                Day/       8)                                          Issuer's             (D) or       (Instr. 4)
                                Year)                                                  Fiscal Year          Indirect
                                                                  (A)                  (Instr. 3 and 4)     (I)
                                                                  or                                        (Instr. 4)
                                                       Amount     (D)    Price

<S>                          <C>         <C>          <C>         <C>    <C>           <C>                <C>          <C>         
Common Stock                                                                           2,378,192          I            I(1)        

<FN>
(1)  The shares are held by Novartis Produkte AG, a wholly-owned subsidiary of
     Novartis AG.
</FN>
</TABLE>

Reminder:  Report on a separate line for each class of securities beneficially
owned directly or indirectly.
                                                                          (Over)


<PAGE>
   TABLE II--Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


<TABLE>
<CAPTION>
1.  Title of Derivative      2. Conver-  3. Trans- 4.Trans-    5. Number of         6. Date Exer-      7. Title and Amount of
    Security                    sion or     action   action      Derivative            cisable and        Underlying Securities
    (Instr. 3)                  Exercise    Date     Code        Securities Ac-        Expiration         (Instr. 3 and 4)
                                Price of    (Month/  (Instr. 8)  quired (A) or         Date
                                Deriv-      Day/                 Disposed of (D)       (Month/Day/
                                ative       Year)                (Instr. 3, 4          Year)
                                Security                         and 5)

                                                                                     Date      Expira-                 Amount or
                                                                                     Exer-     tion                    Number of
                                                                 (A)      (D)        cisable   Date       Title        Shares

<S>                            <C>         <C>      <C>          <C>       <C>       <C>       <C>        <C>          <C>


</TABLE>

   TABLE II--Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)
                                  (continued)
<TABLE>
<CAPTION>
8.  Price of       9. Number of        10. Ownership        11. Nature of
    Derivative        Derivative           of Derivative        Indirect
    Security          Securities           Security:            Beneficial
    (Instr. 5)        Beneficially         Direct (D)           Ownership
                      Owned                or Indirect (I)      (Instr. 4)
                      at End of Year       (Instr. 4)
                      (Instr. 4)

<S>                 <C>                 <C>                  <C>


</TABLE>

Explanation of Responses:


**  Intentional misstatements or omissions of facts constitute Federal Criminal
    Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).


Potential persons who are to respond to the collection of information contained 
in this form are not required to respond unless the form displays a currently 
valid OMB number.


               NOVARTIS AG

          /s/ Dr. Urs Barlocher                        2/13/98
 ----------------------------------------      ------------------------
            General Counsel                              Date


          /s/ Christoph Mader                          2/13/98
 ----------------------------------------      ------------------------
        Senior Corporate Counsel                         Date


<PAGE>

Joint Filer Information

Name:               Novartis Produkte AG

Address:            Schwarzwaldallee 215
                    CH-4002 Basel, Switzerland

Designated Filer:   Novartis AG

Issuer &
Ticker Symbol:      CoSensys, Inc. (COCN)

Signature:          NOVARTIS PRODUKTE AG


                    /s/ Dr. Urs Barlocher
                    ----------------------
                     Authorized Signatory


                      /s/ Anita Buchli
                    ----------------------
                     Authorized Signatory



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