COCENSYS INC
DEFS14A, 1998-12-31
PHARMACEUTICAL PREPARATIONS
Previous: STAGECOACH FUNDS INC /AK/, 497, 1998-12-31
Next: MERRILL LYNCH CALIFORNIA INSURED MUNICIPAL BOND FUND OF MERR, 497, 1998-12-31



<PAGE>

                                       
                        SECURITIES AND EXCHANGE COMMISSION

                              WASHINGTON D.C. 20549

                                   SCHEDULE 14A
                                  (RULE 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                   PURSUANT TO SECTION 14(a) OF THE SECURITIES
                               EXCHANGE ACT OF 1934

FILED BY THE REGISTRANT /X/
FILED BY A PARTY OTHER THAN THE REGISTRANT / /

Check the appropriate box:
/ /  Preliminary Proxy Statement   / /  Confidential, for Use of the Commission
/X/  Definitive Proxy Statement         Only (as permitted by Rule 14a-6(e)(2))
/ /  Definitive Additional Materials
/ /  Soliciting Material Pursuant to Rule 14a-11(c) or  Rule 14a-12

                                  COCENSYS, INC.
            -----------------------------------------------------------
                  (Name of Registrant as Specified in its Charter)


            -----------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):
/X/  No fee required.

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     1)   Title of each class of securities to which transaction applies: ______
     2)   Aggregate number of securities to which transaction applies:__________
     3)   Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11: __________________________________
     4)   Proposed maximum aggregate value of transaction:______________________
     5)   Total fee paid:_______________________________________________________
/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
     1)   Amount previously paid:_______________________________________________
     2)   Form, Schedule or Registration Statement No.:_________________________
     3)   Filing Party:_________________________________________________________
     4)   Date Filed:___________________________________________________________

<PAGE>

[LOGO]

                                   COCENSYS, INC.
                                201 Technology Drive
                              Irvine, California 92618


                                                               December 30, 1998

Dear Stockholder:

     On behalf of CoCensys, Inc. (the "Company"), I cordially invite you to 
attend a Special Meeting of Stockholders, which will begin at 2:00 p.m. local 
time on Wednesday, January 27, 1999, at the offices of the Company, 201 
Technology Drive, Irvine, California.  At the meeting, stockholders will be 
asked to approve the issuance by the Company of shares of its Common Stock on 
conversion of shares of the Company's Series E Convertible Preferred Stock, 
which the Company sold on June 8, 1998 to raise $8 million of working 
capital. In addition, the stockholders will be asked to provide the Board of 
Directors discretionary authority to effect a "reverse stock split" whereby 
the Company would issue one new share of Common Stock in exchange for between 
four and ten shares of outstanding Common Stock.

     These are very important matters that may have significant impact on the 
future of the Company.  The accompanying Notice and Proxy Statement describe 
these proposals. We urge you to read this information carefully and vote your 
shares promptly.  The directors and officers of the Company hope that as many 
stockholders as possible will be present at the meeting.  BECAUSE THE VOTE OF 
EACH STOCKHOLDER IS IMPORTANT, WE ASK THAT YOU SIGN AND RETURN THE ENCLOSED 
PROXY CARD IN THE ENVELOPE PROVIDED, WHETHER OR NOT YOU NOW PLAN TO ATTEND 
THIS MEETING.  This will not limit your right to attend the meeting or to 
change your vote at the meeting.

     We appreciate your cooperation and interest in the Company.  To assist 
us in preparation for the meeting, please return your proxy card at your 
earliest convenience.

                                        Sincerely yours,



                                        F. RICHARD NICHOL, PH.D.
                                        Chairman of the Board

<PAGE>

                                   COCENSYS, INC.
                                201 Technology Drive
                              Irvine, California 92618

                     NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JANUARY 27, 1999

TO THE STOCKHOLDERS OF COCENSYS, INC.:

NOTICE IS HEREBY GIVEN that a Special Meeting of Stockholders of CoCensys, 
Inc., a Delaware corporation (the "Company"), will be held on Wednesday, 
January 27, 1999, at 2:00 p.m., local time, at the offices of the Company, 
201 Technology Drive, Irvine, California for the following purposes:

     1.   To approve the issuance by the Company from time to time of shares of
          its Common Stock on conversion of shares of the Company's Series E
          Convertible Preferred Stock and exercise of warrants issued in
          connection with such Series E Convertible Preferred Stock;

     2.   To approve a proposal to provide the Board of Directors the authority
          to amend the Company's Amended and Restated Certificate of
          Incorporation, as amended, to effect, at any time prior to the 1999
          Annual Meeting of Stockholders, a reverse stock split, whereby
          the Company would issue one new share of Common Stock in exchange for
          between four and ten shares of outstanding Common Stock; and

     3.   To transact such other business as may properly come before the
          meeting or any adjournment thereof.

The foregoing items of business are more fully described in the Proxy 
Statement accompanying this Notice.  The Board of Directors has fixed the 
close of business on December 11, 1998, as the record date for the 
determination of stockholders entitled to notice of and to vote at this 
Special Meeting and at any adjournment thereof.

                                        By Order of the Board of Directors,



                                        ROBERT R. HOLMEN
                                        Secretary
Irvine, California
December 30, 1998

- --------------------------------------------------------------------------------
ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND RETURN
THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR
REPRESENTATION AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE.  EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING.
PLEASE NOTE, HOWEVER, THAT IF A BROKER, BANK OR OTHER NOMINEE IS THE RECORD
HOLDER OF YOUR SHARES AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM
THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.
- --------------------------------------------------------------------------------

<PAGE>


                                   COCENSYS, INC.
                                201 TECHNOLOGY DRIVE
                              IRVINE, CALIFORNIA 92618

                                  PROXY STATEMENT
                          SPECIAL MEETING OF STOCKHOLDERS
                            TO BE HELD JANUARY 27, 1999

                   INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

     The enclosed proxy is solicited on behalf of the Board of Directors of 
CoCensys, Inc., a Delaware corporation ("CoCensys" or the "Company"), for use 
at the Special Meeting of Stockholders (the "Special Meeting"), or at any 
adjournment or postponement thereof, for the purposes set forth in this proxy 
statement and in the accompanying Notice of Special Meeting.  The Special 
Meeting will be held at the offices of the Company, 201 Technology Drive, 
Irvine, California, on January 27, 1999, at 2:00 p.m. local time.  The 
Company intends to mail this proxy statement and accompanying proxy card on 
or about December 30, 1998 to all stockholders entitled to vote at the 
Special Meeting.

SOLICITATION

     The Company will bear the entire cost of solicitation of proxies 
including preparation, assembly, printing and mailing of this proxy 
statement, the proxy and any additional information furnished to 
stockholders.  Copies of solicitation materials will be furnished to banks, 
brokerage houses, fiduciaries and custodians holding in their names shares of 
the Company's Common Stock beneficially owned by others to forward to such 
beneficial owners.  The Company may reimburse persons representing beneficial 
owners of Common Stock for their costs of forwarding solicitation materials 
to such beneficial owners.  Original solicitation of proxies by mail may be 
supplemented by telephone, telegram or personal solicitation by directors, 
officers or other regular employees of the Company; no additional 
compensation will be paid to directors, officers or other regular employees 
for such services.  In addition, the Company has retained D.F. King & Co., 
Inc., to conduct additional solicitation of proxies, for which the Company 
will pay D.F. King's customary fee, estimated at $6,000 plus reimbursement of 
expenses.

VOTING RIGHTS AND OUTSTANDING SHARES

     Only holders of record of Common Stock at the close of business on 
December 11, 1998 (the "Record Date") will be entitled to notice of and to 
vote at the Special Meeting.  At the close of business on the Record Date, 
the Company had outstanding and entitled to vote 27,280,949 shares of Common 
Stock. Each holder of record of Common Stock on such date will be entitled to 
one vote for each share held on all matters to be voted upon at the Special 
Meeting, except that holders of the Company's Series E Convertible Preferred 
Stock (the "Series E Preferred Stock") and warrants issued in connection 
therewith are not entitled to vote shares of Common Stock acquired upon 
conversion of the Series E Preferred Stock or exercise of such warrants on 
Proposal 1.

     The inspector of election appointed for the meeting will separately 
tabulate affirmative and negative votes, abstentions and broker non-votes. 
Abstentions will be counted toward the tabulation of votes cast on proposals 
presented to the stockholders and will have the same effect as negative 
votes. Broker non-votes are counted toward a quorum.  With respect to 
Proposal 1, broker non-votes are not counted for any purpose in determining 
whether the matter has been approved.  With respect to Proposal 2, broker 
non-votes will have the same effect as negative votes.

                                      -1-
<PAGE>

REVOCABILITY OF PROXIES

     Any person giving a proxy pursuant to this solicitation has the power to 
revoke it at any time before it is voted.  It may be revoked by filing with 
the Secretary of the Company, at the Company's principal executive office, 
201 Technology Drive, Irvine, California 92618, a written notice of 
revocation or a duly executed proxy bearing a later date, or it may be 
revoked by attending the meeting and voting in person.  Attendance at the 
meeting will not, by itself, revoke a proxy.

STOCKHOLDER PROPOSALS

     The deadline for submitting a stockholder proposal for inclusion in the 
Company's proxy statement and form of proxy for the Company's 1999 Annual 
Meeting of Stockholders pursuant to Rule 14a-8 of the Securities and Exchange 
Commission (the "Commission") is January 2, 1999.  The deadline for 
submitting a stockholder proposal or a nomination for director that is not to 
be included in such proxy statement and proxy is also January 2, 1999.

                                   PROPOSAL 1
APPROVAL OF THE ISSUANCE BY THE COMPANY FROM TIME TO TIME OF SHARES OF ITS 
COMMON STOCK ON CONVERSION OF SHARES OF THE COMPANY'S SERIES E CONVERTIBLE 
PREFERRED STOCK AND EXERCISE OF WARRANTS ISSUED IN CONNECTION WITH SUCH 
SERIES E CONVERTIBLE PREFERRED STOCK

     Under this Proposal, the Company is seeking stockholder approval to 
issue shares of its Common Stock on conversion of shares of the Series E 
Preferred Stock and exercise of warrants issued in connection with the sale 
of the Series E Preferred Stock.  As discussed more fully below, the Company 
sold 8,000 shares of Series E Preferred Stock, along with Warrants to 
purchase 350,000 shares of Common Stock (the "Initial Warrants"), in order to 
raise $8 million in working capital to fund product development and clinical 
trials.  Under the terms of sale of Series E Preferred Stock and Initial 
Warrants, the Company issued to the investors additional Warrants to purchase 
100,000 shares of Common Stock on November 8, 1998 (the "Additional Warrants" 
and, along with the Initial Warrants, the "Warrants"), and the Company may be 
obligated to sell to the initial investors an additional 2,000 shares of 
Series E Preferred Stock for $2 million on or before August 30, 1999.

      The Series E Preferred Stock is convertible into shares of Common Stock 
at the election of the holders at a price based on the market price of the 
Company's Common Stock as quoted on the Nasdaq National Market at the time of 
conversion. In certain circumstances, in order to maintain listing of the 
Company's Common Stock on the Nasdaq National Market, Nasdaq Stock Market, 
Inc. rules require that the Company seek stockholder approval to issue shares 
of Common Stock in excess of 20% of the outstanding shares of Common Stock.  
Based on the current market price for the Company's Common Stock, the Company 
anticipates that it will be required to issue Common Stock in excess of that 
20% limit upon conversion of the Series E Preferred Stock and exercise of 
Warrants; accordingly, the Company is seeking stockholder approval for the 
Common Stock issuance.

     The exact number of shares of Common Stock issuable on conversion of the 
Series E Preferred Stock is dependent on the market price of the Common Stock 
at the time of conversion and, therefore, is not currently known or 
determinable. The number of shares of Common Stock that may be issuable upon 
conversion of the Series E Preferred Stock at certain assumed conversion 
prices and upon exercise of the Warrants is set forth in the table on page 5 
below. There is no limit on the number of shares that may be issuable upon 
conversion of the Series E Preferred Stock. ACCORDINGLY, STOCKHOLDERS ARE 
BEING ASKED IN THIS PROPOSAL 1 TO AUTHORIZE THE ISSUANCE OF SUCH CURRENTLY 
INDETERMINATE NUMBER OF SHARES OF COMMON STOCK AS MAY BE REQUIRED TO EFFECT 
CONVERSIONS OF SERIES E PREFERRED STOCK AND EXERCISE OF WARRANTS IN 
ACCORDANCE WITH THEIR RESPECTIVE TERMS AS DESCRIBED BELOW AND, IN THE CASE OF 
THE SERIES E PREFERRED STOCK, IN THE CERTIFICATE OF DESIGNATION INCLUDED AS 
APPENDIX A TO THIS PROXY STATEMENT.

     THE BOARD OF DIRECTORS STRONGLY RECOMMENDS THAT THE STOCKHOLDERS VOTE IN 
FAVOR OF THIS PROPOSAL.  AS DISCUSSED MORE FULLY BELOW, FAILURE TO APPROVE 
THIS PROPOSAL MAY FORCE THE COMPANY TO REDEEM THE SERIES E PREFERRED STOCK, 
WHICH COULD SIGNIFICANTLY DEPLETE THE COMPANY'S CASH RESERVES AND MATERIALLY 
ADVERSELY AFFECT ITS OPERATIONS AND FINANCIAL CONDITION.

TERMS OF PREFERRED STOCK AND WARRANTS

     CONVERSION OF SERIES E PREFERRED STOCK.  On June 8, 1998 (the "Closing 
Date"), the Company sold 8,000 shares of Series E Preferred Stock and the 
Initial Warrants for an aggregate purchase price of $8 million in a private 
placement to three investors pursuant to Regulation D of the Securities Act 
of 1933, as amended.  Each share of Series E Preferred Stock is convertible 
into the number of shares of Common Stock equal to (a) the stated value of a 

                                      -2-
<PAGE>

share of Series E Preferred Stock ($1,000) plus any accrued and unpaid 
dividends on the date of conversion divided by (b) the "Conversion Price," 
which equals the lesser of (i) the average of the three lowest trading prices 
during the 15 trading days ending one trading day prior to the conversion, 
multiplied by 100% (until October 8, 1998) or 90% (after October 8, 1998), or 
(ii) $3.93.

     The Series E Preferred Stock may be converted into Common Stock at any 
time at the election of the holder, subject to the limitation that no holder 
can convert its shares of Series E Preferred Stock into Common Stock if such 
conversion would result in it, along with its affiliates, being the 
beneficial owner of more than 4.9% of the outstanding Common Stock of the 
Company.  The preceding condition may be waived by the holder by providing 61 
days' notice to the Company.  The Series E Preferred Stock automatically 
converts on June 8, 2001 if not converted earlier.

     DIVIDENDS.  The Series E Preferred Stock accrues a 7.5% per annum 
dividend until converted, subject to reduction in the dividend rate to (i) 
5.5%, if the Common Stock trades at or above $4.05 per share for 10 
consecutive trading days, (ii) 3.5%, if the Common Stock trades at or above 
$4.95 per share for 10 consecutive trading days and (iii) 1.5%, if the Common 
Stock trades at or above $6.00 per share for 10 consecutive trading days, in 
each case so long as the price threshold is met.  Dividends are payable 
quarterly in cash or, at the election of the Company, by adding the amount of 
the dividend to the conversion value of the Series E Preferred Stock.

     VOTING RIGHTS.  Prior to conversion or exercise, holders of the Series E 
Preferred Stock and Warrants do not have voting rights except as required by 
the Delaware General Corporation Law.  Upon receipt of Common Stock following 
conversion of Series E Preferred Stock or exercise of Warrants, the holders 
are entitled to vote Common Stock received on such conversion or exercise on 
an equivalent basis with all other Common Stock; however, the holders of 
Series E Preferred Stock and Warrants may not vote any Common Stock held by 
them on this Proposal 1 if the holders received the Common Stock on 
conversion of the Series E Preferred Stock or exercise of Warrants.

     WARRANTS.  The Initial Warrants remain exercisable for five years from 
the date of issuance, with an exercise price of $4.50 per share.  On November 
8, 1998, each initial investor in the Series E Preferred Stock received its 
pro rata portion of the Additional Warrants exercisable for $0.625 per share, 
based on the investors having held at least 65% of the Series E Preferred 
Stock purchased by each investor as of that date.  The Additional Warrants 
also remain exercisable for five years from date of issuance.

     REGISTRATION OF SHARES.  The Company filed a registration statement with 
the Commission on Form S-3 registering the resale of up to 12,000,000 shares 
of Common Stock issuable upon conversion of the Series E Preferred Stock and 
350,000 shares issuable upon exercise of the Initial Warrants.  The 
registration statement was declared "effective" by the Commission on 
September 4, 1998.  The Company is required to register additional shares 
with the Commission (i) as necessary to cover resale of shares of Common 
Stock in excess of the initial 12,000,000 issuable upon conversion of Series 
E Preferred Stock and (ii) to cover resale of up to 100,000 shares of Common 
Stock issuable on exercise of the Additional Warrants.  The Company intends 
to file a registration statement on Form S-3, if available, covering those 
additional shares promptly following the Special Meeting.

     SALE OF ADDITIONAL SERIES E PREFERRED STOCK.  During the period 
beginning December 3, 1998 (90 days after the Commission declared the 
registration statement effective) and ending August 30, 1999 (360 days after 
that declaration), the Company is obligated to sell, and the investors are 
obligated to purchase, an additional $2 million in Series E Preferred Stock 
subject to, among other things, the closing price for the Common Stock being 
greater than $3.75 per share for 10 consecutive trading days.

     REDEMPTION AND REPURCHASE.  If at any time the number of shares issued 
on conversion of Series E Preferred Stock and exercise of Warrants equals 
19.99% of the number of shares of Common Stock outstanding as of the Closing 
Date, and if the Company is then prevented from issuing additional shares of 
Common Stock on conversion of the Series E Preferred Stock and has not 
obtained the approval of the Company's stockholders in accordance with its 
listing requirements on the Nasdaq National Market, then the Company is 
required to redeem the Series E Preferred Stock at 110% of the value of 
Common Stock into which the Series E Preferred Stock is then convertible.  
SEE "Nasdaq Limitation on Common Stock Issuance," below.

                                      -3-
<PAGE>

     In the event of an acquisition, merger or change of control of the 
Company, the holders of Series E Preferred Stock may elect to have the 
Company repurchase their holdings for 125% of the stated value (including 
accrued dividends) of the shares.  If the holders do not elect for the 
Company to repurchase the shares, the Company has the right to redeem the 
Series E Preferred Stock in connection with an acquisition, merger or other 
change of control at the greater of 130% of stated value (including accrued 
dividends) or 100% of the value of Common Stock into which the Series E 
Preferred Stock is then convertible.  If the holders do not elect for the 
Company to repurchase the shares, and the Company does not elect to redeem 
the shares, the holders of Series E Preferred Stock receive either equivalent 
shares in the acquiring entity or receive the consideration (E.G. cash or 
securities of the acquiring entity) paid to holders of Common Stock.  
Notwithstanding the foregoing, if any acquisition, merger or change of 
control is to be accounted for on a "pooling of interests" basis, the holders 
of the Series E Preferred Stock are required to accept the greater of (i) the 
amount to be received on repurchase (125% of stated value) or (ii) the 
securities of the acquiring entity that the holder would otherwise receive in 
the transaction in exchange for the shares of Series E Preferred Stock.

     The Company also may be required to redeem the Series E Preferred Stock, 
at the election of the holder, under certain events of default, including 
bankruptcy events and delisting of the Common Stock from the Nasdaq National 
Market (SEE Proposal 2 below), in each case at the greater of 130% of stated 
value (including accrued dividends) or 100% of the value of Common Stock into 
which the Series E Preferred Stock is then convertible.

NASDAQ LIMITATION ON COMMON STOCK ISSUANCE

     The Company's Common Stock is listed on the Nasdaq National Market.  In 
order to maintain listing on the Nasdaq National Market, the Company must 
comply with certain rules and listing standards promulgated by the Nasdaq 
Stock Market, Inc. ("Nasdaq").  In particular, Rule 4460(i)(1)(D) of Nasdaq 
requires companies listed on the Nasdaq National Market to obtain approval of 
the stockholders prior to issuing common stock (or securities convertible 
into or exercisable for common stock) in a private financing at a price less 
than the market value of the common stock, where the number of shares of 
common stock to be issued (or issuable) is at least 20% of the common stock 
or voting power of the Company outstanding prior to the issuance.  Therefore, 
the Company is required to obtain the approval of the holders of a majority 
of its Common Stock prior to issuing shares of Common Stock as a dividend on 
or upon conversion of the Series E Preferred Stock or exercise of Warrants in 
excess of an aggregate of 20% of the number of shares of Common Stock 
outstanding on the original Closing Date of sale of the Series E Preferred 
Stock and Warrants.  At that time, 20% of the outstanding shares equaled 
4,932,948 shares (the "20% Share Limit").  In order for the Company to issue 
shares in excess of the 20% Share Limit, the Company must obtain stockholder 
approval.

     IF THE COMPANY FAILS TO OBTAIN THE NECESSARY APPROVAL, THE COMPANY WOULD 
BE REQUIRED TO REDEEM THE THEN-OUTSTANDING SERIES E PREFERRED STOCK FOR CASH 
IN AN AMOUNT EQUAL TO 110% OF THE AGGREGATE CONVERSION PRICE THEN IN EFFECT. 
REDEMPTION OF THE SERIES E PREFERRED STOCK COULD SIGNIFICANTLY DEPLETE THE 
COMPANY'S CASH RESERVES AND MATERIALLY ADVERSELY AFFECT ITS OPERATIONS AND 
FINANCIAL CONDITION.

     Specifically, if the stockholders do not approve this Proposal 1, then 
the Company will be limited to issuing 4,932,948 shares of stock on 
conversion of the Series E Preferred Stock and exercise of the Warrants.  
That 20% Share Limit is applied pro rata to each holder of Series E Preferred 
Stock and Warrants (E.G. the holder of 10% of the Series E Preferred Stock 
and Warrants is entitled to receive up to 10% of the 4,932,948 shares, or 
493,295 shares, on conversion of Series E Preferred Stock and exercise of 
Warrants).  Once the Series E Preferred Stock ceases to be convertible 
because the Company has reached the 20% Share Limit, and if the stockholders 
have failed to approve issuance of Common Stock above the 20% Share Limit, 
then the Company must immediately redeem all of the outstanding Series E 
Preferred Stock (which may be required as soon as five (5) business days 
after reaching the 20% Share Limit) at 110% of the market value of Series E 
Preferred Stock, based on the then-applicable conversion price.

     The amount of cash that the Company would be required to expend to redeem
the outstanding Series E Preferred Stock could vary greatly depending on the
market price and volatility of the Common Stock.  Based on a 

                                       -4-
<PAGE>

conversion price of $0.422 (90% of the average of the three lowest trading 
prices during the 15 trading days ending one trading day prior to December 
11, 1998) and the current market price of the Common Stock on December 11, 
1998 of $0.4375 per share, the Company would be required to pay $7,639,358 to 
redeem the outstanding Series E Preferred Stock, which would substantially 
deplete the Company's cash reserves and materially and adversely affect the 
Company's operations and financial condition.

EFFECT OF SALE OF SERIES E STOCK AND WARRANTS ON HOLDERS OF COMMON STOCK

     At the time the first $8 million of Series E Preferred Stock was sold, 
the closing price for the Company's Common Stock on the Nasdaq National 
Market was $3.00 per share, so that the Series E Preferred Stock then would 
have converted into approximately 2,700,000 shares of Common Stock, which was 
well below the 20% Share Limit.  Since that time, the market price of the 
Company's Common Stock has declined significantly; as of December 11, 1998, 
the closing price for the Company's Common Stock on the Nasdaq National 
Market was $0.4375 per share. As of that date, 2,563,060 shares had been 
issued on conversion of $1,555,000 of Series E Preferred Stock, and an 
additional 15,873,991 shares were issuable on conversion of the remaining 
$6,445,000 (plus accrued dividends of $251,840) of Series E Preferred Stock 
then outstanding, based on the conversion price in effect at that time of 
$0.422 per share.  The number of shares issuable on future conversions may 
prove to be significantly greater in the event of a decrease in the market 
price of the Common Stock, or less if the market price of the Common Stock 
rises. Stockholders may experience substantial dilution of their investment 
upon conversion of the Series E Preferred Stock.

          In addition, the Company is required to issue up to 450,000 shares 
of Common Stock on exercise of the Warrants.  If the conditions to issuing 
the additional 2,000 shares ($2 million) of Series E Preferred Stock are met 
(which conditions include that the closing price for the Common Stock is 
greater than $3.75 per share for 10 consecutive trading days), the Company 
will be obligated to issue additional shares of Common Stock on conversion of 
those shares of Series E Preferred Stock.  The following table illustrates 
the effect of various conversion prices, assuming all remaining Series E 
Preferred Stock (including accrued dividends), plus the $2 million additional 
Series E Preferred Stock that may be issued, is converted at the same time at 
these prices:

<TABLE>
<CAPTION>
                                                     Common Shares                                                Total Common
             Common Shares         Common Shares       Issuable            Common Shares                          Shares Issuable
Assumed         Issued on          Issuable on        Conversion of         Issuable on           Total          As a % of Shares
Conversion     Conversion           Conversion          Additional           Exercise         Common Shares     Outstanding After
Price (1)   Prior to 12/11/98      At 12/11/98        $2 million (2)        of Warrants         Issuable          Conversion (3)
- ----------  -----------------      -------------     ---------------       -------------      -------------     ------------------
<S>         <C>                    <C>               <C>                   <C>                <C>               <C>              

$0.25          2,563,060            26,787,360          8,000,000             450,000          37,800,420              60.6%
$0.50          2,563,060            13,393,680          4,000,000             450,000          20,406,740              45.3%
$1.00          2,563,060             6,696,840          2,000,000             450,000          11,709,900              32.3%
$2.00          2,563,060             3,348,420          1,000,000             450,000           7,361,480              23.0%
$3.00          2,563,060             2,232,280            666,667             450,000           5,912,007              19.4%
$3.93(4)       2,563,060             1,704,031            508,906             450,000           5,225,997              17.5%

</TABLE>

- ---------------
(1)  The conversion price equals the lesser of (i) the average of the three
     lowest trading prices during the 15 trading days ending one trading day
     prior to the conversion, multiplied by 100% (until October 8, 1998) or 90%
     (after October 8, 1998), or (ii) $3.93.

(2)  The additional $2 million in Series E Preferred Stock is issuable only if,
     among other conditions, the closing price for the Common Stock is greater
     than $3.75 per share for 10 consecutive trading days on or before
     August 30, 1999.

(3)  Assumes that the number of shares outstanding other than shares issued or
     issuable on conversion of Series E Preferred Stock and exercise of Warrants
     is 24,594,700, which was the number of shares outstanding at June 8, 1998.

(4)  Represents the maximum conversion price.

                                      -5-
<PAGE>

     Note that, under applicable Delaware law and the Company's Amended and 
Restated Certificate of Incorporation, as amended, the Board of Directors has 
the authority, without further action by the stockholders, to issue 
additional shares of preferred stock in one or more series and to fix the 
rights, preferences, privileges and restrictions granted to or imposed upon 
any series of unissued preferred stock and to fix the number of shares 
constituting any series and the designation of such series, without any 
further vote or action by the stockholders.

POTENTIAL FOR CHANGE OF CONTROL

     The approval of this Proposal 1 could, depending on the market prices of 
the Common Stock during the periods prior to conversion of the Series E 
Preferred Stock, result in the issuance of a large number of shares of Common 
Stock, thereby possibly resulting in a change of control of the Company if 
the converting holders were to retain such shares of Common Stock rather than 
sell them.  Under the terms of the Series E Convertible Preferred Stock, no 
holder can convert its shares into Common Stock if such conversion would 
result in it, along with its affiliates, being the beneficial owner of more 
than 4.9% of the Common Stock that would be outstanding after giving effect 
to such conversion. However, this restriction can be terminated at any time 
upon 61 days' prior written notice to the Company by the affected holder.

     Note also that, under Nasdaq rules and listing standards, the Company must 
obtain stockholder approval for transactions that result in a "change of 
control."  ALTHOUGH THE COMPANY DOES NOT BELIEVE THAT SALE OF THE SERIES E 
CONVERTIBLE PREFERRED STOCK AND WARRANTS, AND ISSUANCE OF COMMON STOCK ON 
CONVERSION AND EXERCISE THEREOF, CONSTITUTES A CHANGE OF CONTROL UNDER THESE 
RULES, IF THE TRANSACTIONS WERE TO BE SO CONSTRUED, THE APPROVAL SOUGHT UNDER 
THIS PROPOSAL 1 WILL BE EFFECTIVE TO SATISFY THE STOCKHOLDER VOTE 
REQUIRED FOR A CHANGE OF CONTROL.  The Company's opinion that these 
transactions do not constitute a change of control is based on the facts that 
(i) holders of Series E Preferred Stock were not granted voting rights, (ii) 
the holders have no contractual or other right to elect a director or 
otherwise influence management of the Company, (iii) there has been no change 
in the Company's President & Chief Executive Officer or composition of the 
Board of Directors since the Closing Date (other than the election of one new 
director nominated by the Board prior to the Closing Date), and (iv) no 
holder can convert its shares of Series E Preferred Stock into Common Stock 
if such conversion would result in it being the beneficial owner of more than 
4.9% of the Common Stock without giving 61 days' prior written notice to the 
Company (and no holder has provided such notice as of the date of this Proxy 
Statement).

     Stockholders should consider also that the potential for the issuance of 
a significant number of shares of Common Stock on conversion of the Series E 
Preferred Stock and exercise of Warrants may tend to have the effect of 
discouraging tender offers for the Company or delaying, deferring or 
preventing a change of control of the Company.

VOLATILITY OF COCENSYS COMMON STOCK

     The securities markets have from time to time experienced significant 
price and volume fluctuations that may be unrelated to the operating 
performance of particular companies.  In addition, the market prices of the 
common stock of many publicly traded biopharmaceutical companies, including 
the Company, have in the past been, and can in the future be expected to be, 
especially volatile. Announcements of technological innovations or new 
products by the Company or its competitors, developments or disputes 
concerning patents or proprietary rights, publicity regarding actual or 
potential medical results relating to products under development by the 
Company or its competitors, regulatory developments in both the United States 
and foreign countries, public concern as to the safety of biotechnology 
products and economic and other external factors, as well as period-to-period 
fluctuations in the Company's financial results, may have a significant 
impact on the market price of the Company's Common Stock.

     The sale of a large number of shares of the Company's Common Stock in the
public market following conversion of the Series E Preferred Stock could have an
adverse effect on the market price of the Company's Common Stock.  Substantially
all of the outstanding shares of the Company's Common Stock are available for
immediate sale in the public markets, subject to volume restrictions applicable
to affiliates.  Approximately 

                                       -6-
<PAGE>

4,500,000 additional shares subject to currently exercisable options and 
warrants also may be sold freely immediately following exercise thereof.

REQUIRED VOTE

     The affirmative vote of a majority of the shares present in person or 
represented by proxy and entitled to vote is necessary to approve issuance of 
the shares of Common Stock in accordance with this Proposal 1.

AVAILABLE INFORMATION

     The terms of the Series E Preferred Stock and Warrants are complex and 
only briefly summarized in this Proxy Statement.  Stockholders wishing 
further information concerning the rights, preferences and terms of the 
Series E Preferred Stock should review the full description of the Series E 
Preferred Stock contained in the Certificate of Powers, Designation, 
Preferences, Rights and Limitations of Series E Convertible Preferred Stock 
of CoCensys, Inc., included as APPENDIX A to this Proxy Statement.  The 
Series E Preferred Stock and Warrant purchase agreement, along with the forms 
of Initial Warrant and Additional Warrant, may be obtained by any of the 
following methods:

     1.   By reviewing the copy on file with the Securities and Exchange 
Commission (the "Commission") at the public reading rooms maintained by the 
Commission at Securities Exchange Commission, Public Reference Branch, Stop 
1-2, 450 Fifth Street, NW, Washington, DC, 20549-1004;

     2.   By viewing the copy maintained in the Commission's "EDGAR" 
database, which may be accessed through the Commission's web site at 
http://www.sec.gov; or

     3.   By submitting a written request to the Company, attention Investor 
Relations, 201 Technology Drive, Irvine, CA 92618.

                         THE BOARD OF DIRECTORS UNANIMOUSLY
                          RECOMMENDS A VOTE FOR PROPOSAL 1

                                      -7-
<PAGE>

                                     PROPOSAL 2
APPROVAL OF A PROPOSAL TO PROVIDE THE BOARD OF DIRECTORS THE AUTHORITY TO 
AMEND THE COMPANY'S AMENDED AND RESTATED CERTIFICATE OF INCORPORATION, AS 
AMENDED, TO EFFECT, AT ANY TIME PRIOR TO THE 1999 ANNUAL MEETING OF 
STOCKHOLDERS, A REVERSE STOCK SPLIT, WHEREBY THE COMPANY WOULD ISSUE ONE NEW 
SHARE OF COMMON STOCK IN EXCHANGE FOR BETWEEN FOUR AND TEN SHARES OF 
OUTSTANDING COMMON STOCK

BACKGROUND

     The Company's stockholders are being asked in this Proposal 2 to 
authorize the Company to amend the Company's Amended and Restated Certificate 
of Incorporation, as amended (the "Restated Certificate"), to effect, at any 
time prior to the 1999 Annual Meeting of Stockholders (currently scheduled 
for June 9, 1999), a reverse stock split of the Company's Common Stock 
whereby the Company would issue one new share of Common Stock in exchange for 
between four and ten shares of outstanding Common Stock (the "Reverse Split").

     THE BOARD OF DIRECTORS STRONGLY RECOMMENDS THAT THE STOCKHOLDERS VOTE IN 
FAVOR OF THIS PROPOSAL.  AS DISCUSSED MORE FULLY BELOW, APPROVAL OF THIS 
PROPOSAL MAY BE NECESSARY TO MAINTAIN LISTING OF THE COMPANY'S COMMON STOCK 
ON THE NASDAQ NATIONAL MARKET.

     The complete text of the form of amendment to the Restated Certificate 
that would be filed with the office of the Secretary of State of the State of 
Delaware to effect the Reverse Split is set forth in Appendix B to this Proxy 
Statement; provided, however, that such text is subject to amendment to 
include such changes as may be required by the office of the Secretary of 
State of the State of Delaware and as the Company's Board of Directors (the 
"Board") deems necessary and advisable to effect the Reverse Split in the 
range described above.

REASONS FOR THE REVERSE SPLIT

     The Board believes that the Reverse Split is desirable for a number of 
reasons.  First, the Board believes that the Reverse Split may be necessary 
to enable the Company to maintain the listing of the Company's Common Stock 
on the Nasdaq National Market.  Second, the Reverse Split may improve the 
Company's ability to raise new capital.  Finally, the Board believes that the 
Reverse Split will improve the marketability and liquidity of the Company's 
Common Stock.  In addition, the Board believes that stockholder approval of 
an exchange ratio range (as opposed to approval of a specified exchange 
ratio) in which the Reverse Split may be effected will provide the Board with 
maximum flexibility to achieve the purposes of the Reverse Split and, 
therefore, is in the best interests of the Company and its stockholders.

     NASDAQ LISTING.  The Company's shares of Common Stock have been listed, 
and have traded, on the Nasdaq National Market since January 1993 when the 
Company completed its initial public offering.  The rules of the Nasdaq Stock 
Market require that, as a condition of the continued listing of a Company's 
securities on the Nasdaq National Market, a company must satisfy certain 
maintenance requirements.  The maintenance requirements generally require 
that a company meet certain minimum criteria relating to its financial 
condition, results of operations and trading market for its listed 
securities. The maintenance criteria applicable to the Company consist of 
maintaining (i) a public float of at least 750,000 shares, (ii) a market 
value of the public float of at least $5 million, (iii) a minimum bid price 
equal to or greater than $1.00 per share, (iv) at least 400 shareholders 
("round-lot" holders, as described under "MARKETABILITY AND LIQUIDITY OF 
COMMON STOCK," below), (v) net tangible assets of at least $4 million, (vi) 
at least two registered market makers and (vii) compliance with certain 
corporate governance requirements.  The Company believes that it satisfies 
all of these maintenance criteria other than having a minimum bid price equal 
to or greater than $1.00 per share.

     ON DECEMBER 1, 1998, THE COMPANY RECEIVED A NOTICE FROM THE NASDAQ STOCK 
MARKET CONFIRMING NASDAQ'S DETERMINATION THAT THE COMPANY NO LONGER MEETS THE 
MINIMUM BID PRICE REQUIREMENT.  NASDAQ HAS PROVIDED THE COMPANY UNTIL 
FEBRUARY 28, 1999 TO CORRECT THE DEFICIENCY; OTHERWISE, THE 

                                       -8-
<PAGE>

COMPANY'S SECURITIES WILL BE DELISTED FROM THE NASDAQ NATIONAL MARKET AT THE 
OPEN OF BUSINESS ON MARCH 2, 1999.  BASED ON THE RECENT TRADING HISTORY OF 
THE COMPANY'S COMMON STOCK, UNLESS THE STOCKHOLDERS APPROVE THIS PROPOSAL, 
THE COMPANY MAY BE UNABLE TO MEET THE MINIMUM BID PRICE REQUIREMENT AND THE 
COMPANY'S COMMON STOCK MAY BE DELISTED FROM THE NASDAQ NATIONAL MARKET.

     The Company believes that if the Reverse Split is approved by the 
stockholders at the Special Meeting, and the Reverse Split is effectuated, 
the Company's Common Stock should initially have a minimum bid price in 
excess of the $1.00 per share necessary to maintain its listing on the Nasdaq 
National Market.  The Company would also need to continue to satisfy all 
other maintenance criteria. There can be no assurance, however, that the 
Company will be successful in meeting and maintaining these maintenance 
criteria or that, even if these maintenance criteria are met, the Company's 
Common Stock will continue to be traded on the Nasdaq National Market.

     If the Reverse Split is not approved by the stockholders at the Meeting, 
then it is possible, depending on the volatility and future price of the 
Company's Common Stock and the Company's ability to meet the maintenance 
criteria described above, that the Company's Common Stock will be delisted 
from the Nasdaq National Market on March 2, 1999.  The delisting of the 
Company's Common Stock from the Nasdaq National Market could adversely affect 
the liquidity of the Company's Common Stock and the ability of the Company to 
raise capital.  In the event of delisting, the shares of Common Stock would 
likely be quoted in the "pink sheets" maintained by the National Quotation 
Bureau, Inc. or the NASD Electronic Bulletin Board.  In that event, the 
spread between the bid and ask price of the shares of Common Stock is likely 
to be greater than at present, and stockholders may experience a greater 
degree of difficulty in engaging in trades of shares of Common Stock.

     CAPITAL RAISING EFFORTS.  The Company will require additional sources of 
capital to fund its existing and future product development efforts and 
clinical trials and to fund continuing operations.  In meetings with its 
financial advisors, the Company has been advised that an increase in per 
share price of the Company's Common Stock, which the Company expects 
initially as a consequence of the Reverse Split, may enhance the 
acceptability of the Common Stock by the financial community and the 
investing public and broaden the investor pool from which the Company might 
be able to obtain additional financing.  In theory, the total number of 
shares outstanding should not, by itself, affect the marketability of the 
Common Stock, the type of investor who acquires it or the Company's 
reputation in the financial community.  As a practical matter, however, the 
opposite is in fact often the case.  For example, because of the trading 
volatility often associated with low-priced stocks, as a matter of policy 
many institutional investors are prohibited from purchasing such stocks. For 
the same reason, brokers often discourage their customers from purchasing 
such stocks.

     The reduction in the number of outstanding shares of Common Stock caused 
by the Reverse Split is anticipated initially to increase proportionally the 
per share market price of the Common Stock.  However, because some investors 
may view the Reverse Split negatively in that it reduces the number of shares 
available in the public market, there can be no assurance that the market 
price of the Common Stock will reflect proportionately the Reverse Split, or 
that such price, if it does rise proportionally to such levels, will continue 
to escalate or be sustained in the future.

     MARKETABILITY AND LIQUIDITY OF COMMON STOCK.  The Board also believes 
that the increased market price of its Common Stock expected as a result of 
the Reverse Split will improve the marketability and liquidity of the 
Company's Common Stock by appealing to a broader market than that which 
currently exists and will encourage interest and trading in the Common Stock. 
 As previously noted, many brokerage houses and institutional investors have 
internal policies and practices that either prohibit them from investing in 
low-priced stocks or tend to discourage individual brokers from recommending 
low-priced stocks to their customers.  Some of those policies and practices 
may function to make the processing of trades in low-priced stocks 
economically unattractive to brokers. Additionally, because brokers' 
commissions on low-priced stocks generally represent a higher percentage of 
the stock price than commissions on higher-priced stocks, the current average 
price per share of the Company's Common Stock can result in individual 
stockholders paying transaction costs representing a higher percentage of 
their total share value than would be the case if the share price were 
substantially higher.  If the Reverse Split is 

                                      -9-
<PAGE>

implemented, however, holders of fewer than 100 shares of Common Stock 
("odd-lots") after the Reverse Split is effected may be charged brokerage 
fees that are proportionately higher than holders of more than 100 shares of 
Common Stock ("round-lots").  The Board is hopeful that the anticipated 
higher market price will reduce, to some extent, the negative effects on the 
liquidity and marketability of the Company's Common Stock inherent in some of 
the policies and practices of institutional investors and brokerage houses 
described above.

     Stockholders should note that the effect of the Reverse Split upon the 
market price of the Company's Common Stock cannot be accurately predicted.  
In particular, there is no assurance that the price for shares of the Common 
Stock after the Reverse Split will be four to ten times the prices for shares 
of the Common Stock immediately prior to the Reverse Split.  Furthermore, 
there can be no assurance that the proposed Reverse Split will achieve the 
desired results that have been outlined above, nor can there be any assurance 
that the Reverse Split will not adversely impact the market price of the 
Common Stock or, alternatively, that any increased price per share of the 
Common Stock immediately after the proposed Reverse Split will be sustained 
for any prolonged period of time.

BOARD DISCRETION TO IMPLEMENT REVERSE SPLIT

     If the Reverse Split is approved by the stockholders of the Company at 
the Special Meeting, the Reverse Split will be effected, if at all, only upon 
a determination by the Board, after consultation with its financial advisors, 
that the Reverse Split (in an exchange ratio determined by the Board upon 
advice of its financial advisors within the limits set forth in this Proposal 
2) is in the best interests of the Company and its stockholders at that time. 
Such determination will be based upon certain factors, including but not 
limited to the then-current price of the Company's Common Stock, the 
availability of additional working capital, existing and expected 
marketability and liquidity of the Common Stock, prevailing market conditions 
and the likely effect on the market price of the Common Stock.  
Notwithstanding approval of the Reverse Split by the stockholders, the Board 
may, in its sole discretion, determine not to effect the Reverse Split prior 
to the 1999 Annual Meeting of Stockholders.  If the Board fails to implement 
the Reverse Split prior to such meeting, stockholder approval again would be 
required prior to implementing any reverse split.

EFFECTS OF THE REVERSE SPLIT ON REGISTRATION, VOTING RIGHTS AND PREFERRED 
STOCK

     The Company's Common Stock is currently registered under Section 12(g) 
of the Exchange Act, and the Company is subject to the periodic reporting and 
other requirements of the Exchange Act.  The Reverse Split will not affect 
the registration of the Company's Common Stock under the Exchange Act.  After 
the Reverse Split, assuming that the Company continues to meet all other 
listing criteria, the Company's Common Stock will continue to be reported on 
the Nasdaq National Market under the symbol "COCN" (although Nasdaq will add 
the letter "D" to the end of the trading symbol for a period of 20 trading 
days to indicate the Reverse Split has occurred).

     Proportionate voting rights and other rights of the holders of Common 
Stock will not be affected by the Reverse Split (other than as a result of 
the payment of cash in lieu of fractional shares as described below).  For 
example, a holder of 2% of the voting power of the outstanding shares of 
Common Stock immediately prior to the effective time of the Reverse Split 
will continue to hold 2% of the voting power of the outstanding shares of 
Common Stock after the Reverse Split. Although the Reverse Split will not 
affect the rights of stockholders or any stockholder's proportionate equity 
interest in the Company (subject to the treatment of fractional shares), the 
number of authorized shares of Common Stock will not be reduced and will 
increase the ability of the Board to issue such authorized and unissued 
shares without further stockholder action.  The number of stockholders of 
record will not be affected by the Reverse Split (except to the extent that 
any stockholder holds only a fractional share interest and receives cash for 
such interest after the Reverse Split).

     In April 1995, the Company adopted a Preferred Share Purchase Rights 
Plan that provided for the distribution of a dividend on each share of the 
Company's Common Stock of the right (each, a "Right") to purchase from the 
Company one one-hundredth (1/100th) of a share of Series A Junior 
Participating Preferred Stock ("Series A Preferred Stock").  The Reverse 
Split will result in (i) a reduction in the number of Rights outstanding in 
proportion to the exchange ratio of the Reverse Split and (ii) an adjustment 
to the conversion ratio of the Series A Preferred 

                                     -10-
<PAGE>

Stock that reduces the number of shares of Common Stock issuable upon 
conversion of the Series A Preferred Stock in proportion to the exchange 
ratio of the Reverse Split.

     The Reverse Split also will result in an adjustment to the conversion 
ratio of outstanding shares of the Company's Series C Convertible Preferred 
Stock, Series D Convertible Preferred Stock and Series E Convertible 
Preferred Stock. In each case, the Reverse Split causes reduction in the 
number of shares of Common Stock issuable upon conversion of those series of 
Preferred Stock.  The table below shows the effect of the Reverse Split 
(using the minimum and maximum ratios for the Reverse Split) on the Company's 
Common Stock, Series C Convertible Preferred Stock, Series D Convertible 
Preferred Stock and Series E Convertible Preferred Stock.  Conversions of 
each series of Preferred Stock are based on the December 11, 1998 closing 
price for the Company's Common Stock on the Nasdaq National Market of $0.4375 
per share.

<TABLE>
<CAPTION>
                                   Common Shares          Common Shares        Common Shares
                                   Or Equivalent         Outstanding with   Outstanding with 
Security                       Outstanding (12/11/98)   1:4 Reverse Spilt   1:10 Reverse Split
- --------                       ----------------------   -----------------   ------------------
<S>                            <C>                      <C>                 <C>
Common Stock, $0.001 par value       27,280,949             6,820,237            2,728,095

Series C Convertible Preferred        1,144,165               286,041              114,417
  Stock, $0.001 par value

Series D Convertible Preferred        2,100,074               525,019              210,007
  Stock, $0.001 par value

Series E Convertible Preferred       15,873,991             3,968,498            1,587,399
  Stock, $0.001 par value
</TABLE>

EFFECT ON STOCK OPTIONS, WARRANTS AND PAR VALUE

     The Reverse Split will effect a reduction in the number of shares of 
Common Stock available for issuance under the Company's 1990 Stock Option 
Plan, as amended, the 1992 Non-Employee Directors' Stock Option Plan, as 
amended, the 1996 Equity Incentive Plan, the 1995 Employee Stock Purchase 
Plan and the 1998 Non-Officer Equity Incentive Plan (collectively, the "Stock 
Plans"), as well as shares of Common Stock issuable on exercise of stock 
options outside of the Stock Plans, in proportion to the exchange ratio of 
the Reverse Split.  The aggregate number of shares of Common Stock currently 
authorized and available for issuance under the Stock Plans is approximately 
7,200,000 (including shares subject to outstanding options and shares 
available for future grants) and 45,000 Common Stock shares are authorized 
and available for issuance on exercise of stock options outside of the Stock 
Plans, in each case prior to giving effect to the Reverse Split.  The 
aggregate number of shares authorized and available for issuance on exercise 
of options under the Stock Plans and outside of the Stock Plans will reduce, 
in aggregate, to 1,811,250 shares with a 1:4 reverse split or to 724,500 with 
a 1:10 reverse split.  The exercise prices for options outstanding under the 
Stock Plans and outside of the Stock Plans will be increased proportionate to 
the reverse split ratio.

     The Company also has outstanding warrants to purchase approximately 
2,000,000 shares of the Company's Common Stock.  Under the terms of the 
outstanding warrants, the Reverse Split will effect a reduction in the number 
of shares of Company Common Stock issuable upon exercise of such warrants in 
proportion to the exchange ratio of the Reverse Split and will effect a 
proportionate increase in the exercise price of such outstanding warrants. 
Shares available for issuance under outstanding warrants will reduce to 
500,000 with a 1:4 reverse split, and 200,000 with a 1:10 reverse split.

     The par value of the Company's Common Stock and Preferred Stock will 
remain at $0.001 per share following the effective time of the Reverse Split, 
while the number of shares of Common Stock issued and outstanding will be 
reduced. Consequently, the aggregate par value of the issued and outstanding 
Common Stock also will be reduced.  In addition, although the number of 
authorized shares of Common Stock will remain fixed at 75,000,000, the 
number of authorized but unissued shares of Common Stock (I.E., shares 
available for future issuance) effectively will be increased by the Reverse 
Split.  The issuance of such additional authorized shares, if such shares 
were issued, may have the effect of diluting the 

                                       -11-
<PAGE>

earnings per share and book value per share, as well as the stock ownership 
and voting rights, of outstanding Common Stock.  The effective increase in 
the number of authorized but unissued shares of Common Stock may be construed 
as having an anti-takeover effect by permitting the issuance of shares to 
purchasers who might oppose a hostile takeover bid or oppose any efforts to 
amend or repeal certain provisions of the Company's Restated Certificate or 
Bylaws.

EFFECTIVE DATE

     The Reverse Split would become effective as of the close of business on 
the date of filing (the "Effective Date") of a Certificate of Amendment to 
the Restated Certificate with the office of the Secretary of State of the 
State of Delaware.  Except as explained below with respect to fractional 
shares, on the Effective Date, each share of Common Stock issued and 
outstanding immediately prior thereto (the "Old Common Stock") will be, 
automatically and without any action on the part of the stockholders, 
converted into between 1/4 and 1/10 of a share of the Company's Common Stock 
proposed to be issued in connection with the Reverse Split (the "New Common 
Stock").

EXCHANGE OF STOCK CERTIFICATES AND PAYMENT FOR FRACTIONAL SHARES

     Shortly after the Effective Date, each holder of an outstanding 
certificate theretofore representing shares of Old Common Stock will receive 
from American Stock Transfer & Trust Company, as the Company's exchange agent 
(the "Exchange Agent") for the Reverse Split, instructions for the surrender 
of such certificate to the Exchange Agent.  Such instructions will include a 
form of Transmittal Letter to be completed and returned to the Exchange 
Agent.  As soon as practicable after the surrender to the Exchange Agent of 
any certificate which prior to the Reverse Split represented shares of Old 
Common Stock, together with a duly executed Transmittal Letter and any other 
documents the Exchange Agent may specify, the Exchange Agent shall deliver to 
the person in whose name such certificate had been issued certificates 
registered in the name of such person representing the number of full shares 
of New Common Stock into which the shares of Old Common Stock previously 
represented by the surrendered certificate shall have been reclassified and a 
check for any amounts to be paid in cash in lieu of any fractional share 
interest (as discussed in the next paragraph below).  Each certificate 
representing shares of New Common Stock issued in connection with the Reverse 
Split will continue to bear any legends restricting the transfer of such 
shares that were borne by the surrendered certificates representing the 
shares of Old Common Stock.  Until surrendered as contemplated herein, each 
certificate which immediately prior to the Reverse Split represented any 
shares of Old Common Stock shall be deemed at and after the Reverse Split to 
represent the number of full shares of New Common Stock contemplated by the 
preceding sentence.

     No fractional shares of New Common Stock will be issued as a result of 
the Reverse Split.  In lieu of any such fractional share interest, each 
holder of Old Common Stock who as a result of the Reverse Split would 
otherwise receive a fractional share of New Common Stock will be entitled to 
receive cash in an amount equal to the product obtained by multiplying (i) 
the closing sales price of the Company's Common Stock on the Effective Date 
as reported on the Nasdaq National Market by (ii) the number of shares of Old 
Common Stock held by such holder that would otherwise have been exchanged for 
such fractional share interest.  Such amount will be issued to such holder in 
the form of a check in accordance with the exchange procedures outlined above.

     No service charges, brokerage commissions or transfer taxes will be 
payable by any holder of any certificate which prior to approval of the 
Reverse Split represented any shares of Old Common Stock, except that if any 
certificates of New Common Stock are to be issued in a name other than that 
in which the certificates for shares of Old Common Stock surrendered are 
registered, it will be a condition of such issuance that (i) the person 
requesting such issuance shall pay to the Company any transfer taxes payable 
by reason thereof (or prior to transfer of such certificate, if any) or 
establish to the satisfaction of the Company that such taxes have been paid 
or are not payable, (ii) such transfer must comply with all applicable 
federal and state securities laws, and (iii) such surrendered certificate 
must be properly endorsed and otherwise be in proper form for transfer.

                                       -12-
<PAGE>

NO APPRAISAL RIGHTS

     Under Delaware law, stockholders of the Company are not entitled to 
appraisal rights with respect to the proposed Reverse Split.

MATERIAL FEDERAL INCOME TAX CONSEQUENCES OF THE REVERSE SPLIT

     A summary of the federal income tax consequences of the proposed Reverse 
Split to the Company and to individual stockholders is set forth below.  The 
following discussion is based upon present federal income tax law.  The 
discussion is not intended to be, nor should it be relied on as, a 
comprehensive analysis of the tax issues arising from or relating to the 
proposed Reverse Split.  In addition, the Company has not and will not seek 
an opinion of counsel or a ruling from the Internal Revenue Service regarding 
the federal income tax consequences of the proposed Reverse Split.  
Accordingly, stockholders are advised to consult their own tax advisors for 
more detailed information regarding the effects of the proposed reverse split 
on them under applicable federal, state, local and foreign income tax laws.

     It is intended that the Reverse Split will constitute a reorganization 
(a "Reorganization") within the meaning of Section 368(a)(1)(E) of the 
Internal Revenue Code of 1986, as amended.  Assuming that the Reverse Split 
qualifies as a Reorganization, the following federal income tax consequences 
should result:

     1.   A stockholder will not recognize any gain or loss as a result of 
the Reverse Split except to the extent a stockholder receives cash in lieu of 
a fractional share.  To the extent a stockholder receives cash in lieu of a 
fractional share, for tax purposes the stockholder will be deemed to have 
sold the fractional share to the Company.  Although it is impossible to 
predict with certainty the tax consequences to any individual stockholder, 
such stockholder will likely recognize a gain or loss as a result of the 
repurchase of a fractional share equal to the difference between (i) the 
stockholder's proportionate adjusted basis in such fractional share, and (ii) 
the cash amount received for such fractional share.  Any gain will be treated 
as short-term capital gain taxable at a maximum federal income tax rate of 
39.6% to a non-corporate stockholder if the stockholder has held his shares 
for one year or less prior to the Effective Date or long-term capital gain 
taxable at a maximum federal income tax rate of 20% to a non-corporate 
stockholder if the stockholder has held his shares for more than one year 
prior to the Effective Date.

     2.   The aggregate tax basis of the shares of New Common Stock received 
by the stockholder pursuant to the Reverse Split will equal the aggregate tax 
basis of the shares of Old Common Stock held by the stockholder immediately 
prior to the Effective Date of the Reverse Split reduced by any basis 
allocated to a fractional share for which the stockholder receives cash.  The 
stockholder will be able to "tack" the holding period of the Old Common Stock 
prior to the Reverse Split to the holding period of the New Common Stock 
received by the stockholder as a result of the Reverse Split, provided that 
the shares of Old Common Stock were capital assets in the hands of the 
stockholder.

     3.   Holders of any series of Preferred Stock of the Company will 
recognize no income, gain or loss for federal income tax purposes as a result 
of the changes to the conversion ratios for such stock incident to the 
Reverse Split. The Company will not recognize gain or loss as a result of the 
Reverse Split.

REQUIRED VOTE

     The affirmative vote of the holders of a majority of the shares of 
Common Stock outstanding and entitled to vote is necessary to approve the 
Reverse Split and the amendment to the Restated Certificate to effect the 
Reverse Split.  As result, broker non-votes will have the same effect as 
negative votes.
                                       
                       THE BOARD OF DIRECTORS UNANIMOUSLY
                        RECOMMENDS A VOTE FOR PROPOSAL 2

                                       -13-
<PAGE>

           SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The following table sets forth certain information regarding the 
ownership of the Company's Common Stock as of November 30, 1998 by the 
following stockholders:  (i) each director; (ii) the Company's Chief 
Executive Officer and additional four most highly compensated executive 
officers; (iii) all executive officers and directors of the Company as a 
group; and (iv) all those known by the Company to be beneficial owners of 
more than five percent of the Company's Common Stock.

<TABLE>
<CAPTION>
                                                      NUMBER          PERCENT
BENEFICIAL OWNER(1)                                  OF SHARES        OF TOTAL
- --------------------                                 ---------        --------
<S>                                                  <C>              <C>
Entities Affiliated with Sanderling Ventures(2)
  2730 Sand Hill Road, Suite 200
  Menlo Park, California 94025 . . . . . . . . . . . 2,113,673          7.7
Novartis AG(3)
  Schwarzwaldallee 215
  CH402 Basel, Switzerland . . . . . . . . . . . . . 2,543,902          9.3
Robert G. McNeil, Ph.D.(2)
  c/o Sanderling Ventures, above . . . . . . . . . . 2,214,021          8.1
James C. Blair, Ph.D.(4) . . . . . . . . . . . . . . 1,295,931          4.7
Joann L. Data, M.D., Ph.D.(5). . . . . . . . . . . . . .87,862            *
Kelvin W. Gee, Ph.D.(6). . . . . . . . . . . . . . . . 473,686          1.7
Robert R. Holmen (7) . . . . . . . . . . . . . . . . . .14,583            *
Nancy C. Lan, Ph.D.(8) . . . . . . . . . . . . . . . . 274,263          1.0
Alan C. Mendelson(9) . . . . . . . . . . . . . . . . . .81,082            *
F. Richard Nichol, Ph.D.(10) . . . . . . . . . . . . . 276,317          1.0
Timothy J. Rink, M.D.(11). . . . . . . . . . . . . . . .64,000            *
Robert L. Roe, M.D.. . . . . . . . . . . . . . . . . . . 5,000            *
Lowell E. Sears(12). . . . . . . . . . . . . . . . . . 235,416            *
Eckard Weber, M.D.(13) . . . . . . . . . . . . . . . . 487,070          1.8

All executive officers and directors
  as a group (12 persons)(14). . . . . . . . . . . . 3,295,210         11.5
</TABLE>
- -------------------
*  Less than one percent.

(1)    The table is based on information supplied by officers, directors and
       principal stockholders and on Schedules 13D and 13G filed with the
       Securities and Exchange Commission ("SEC").  Applicable percentages are
       based on 27,280,949 shares outstanding on November 30, 1998, adjusted as
       required by SEC rules and regulations.  Unless otherwise indicated in the
       footnotes to this table, and subject to community property laws were
       applicable, the Company believes that each of the stockholders named in
       this table has sole voting and investment power with respect to the
       shares indicated as beneficially owned.

(2)    Shares held by entities affiliated with Sanderling Ventures consist of
       the following:  (i) 178,512 shares held by Sanderling Venture Partners
       II, L.P.; (ii) 143,286 shares held by Sanderling Ventures Limited, L.P.;
       (iii) 866,095 shares held by Sanderling Venture Partners III, L.P. ("SVP
       III") and 69,834 shares issuable to SVP III on exercise of warrants; (iv)
       179,601 shares held by Sanderling III Biomedical, L.P. ("SB III") and
       12,036 shares issuable to SB III on exercise of warrants; (v) 442,658
       shares held by Sanderling III Limited, L.P. ("Sanderling III") and 36,175
       shares issuable to Sanderling III on exercise of warrants; and (vi)
       180,444 shares held by Sanderling Ventures Management ("SVM") and 5,032
       shares issuable to SVM on exercise of warrants.  Shares held by Dr.
       McNeil include all of the shares held by the entities affiliated with
       Sanderling Ventures (the "Sanderling Shares"), plus 100,348 shares held
       directly by Dr. McNeil.  Dr. McNeil is a general partner or principal of
       each of the entities affiliated with Sanderling Ventures, has voting and
       investment power with respect to the Sanderling Shares and may be deemed
       beneficial owner of such Shares.  Dr. McNeil disclaims beneficial
       ownership of the Sanderling Shares except to the extent of his
       partnership interest in each entity affiliated with Sanderling Ventures.

                                       -14-
<PAGE>

(3)    Consists of the following shares:  (i) 2,378,192 shares held by Novartis
       Produkte AG, a subsidiary of Novartis AG; (ii) 80,297 shares held by
       Sanderling Ventures Limited, L.P., over which Novartis AG has shared
       voting and investment power; and (iii) 85,413 shares held by Sanderling
       III Limited, L.P., over which Novartis AG has shared voting and
       investment power.

(4)    Dr. Blair is a director of the Company.  Shares held by Dr. Blair include
       17,267 shares held directly by Dr. Blair and 28,000 shares subject to
       stock options exercisable within 60 days following November 30, 1998,
       plus the shares held by the following entities affiliated with Domain
       Associates (the "Domain Shares"): (i) 5,664 shares held by Domain
       Associates ("Domain"); (ii) 846,154 shares held by Domain Partners III,
       L.P. ("Domain III") and 338,462 shares issuable to Domain III on exercise
       of warrants; (iii) 29,615 shares held by DP III Associates, L.P. ("DP
       III") and 11,846 shares issuable to DP III on exercise of warrants; and
       (iv) 18,923 shares issuable to Domain Partners II, L.P. ("Domain II") on
       exercise of warrants. Dr. Blair is a general partner of Domain, and is a
       general partner in the general partner of each of Domain II, Domain III
       and DP III.  Dr. Blair has voting and investment power with respect to,
       and may be deemed beneficial owner of, the Domain Shares.  Dr. Blair
       disclaims beneficial ownership of the Domain Shares, and any proceeds
       thereof, that exceed his pecuniary interest therein and/or that are not
       actually distributed to him.

(5)    Dr. Data is the Company's Executive Vice President, Product Development
       and Regulatory Affairs.  Shares listed include 81,666 shares subject to
       stock options exercisable within 60 days following November 30, 1998.

(6)    Dr. Gee is the Company's Chief Scientific Officer and a director.  Shares
       listed include 28,000 shares subject to stock options exercisable within
       60 days following November 30, 1998, 16,800 shares held by members of Dr.
       Gee's immediate family and 61,039 shares held in the Kelvin & Kay Gee
       Living Trust.

(7)    Mr. Holmen is the Company's Vice President, General Counsel and
       Secretary.  Shares listed include 14,583 shares subject to stock options
       exercisable within 60 days of November 30, 1998.

(8)    Dr. Lan is the Company's Vice President, Scientific Affairs and
       Intellectual Property.  Shares listed include 20,000 shares held by Dr.
       Lan as Custodian for a family member and 194,828 shares subject to stock
       options exercisable within 60 days following November 30, 1998.

(9)    Mr. Mendelson is a director of the Company.  Shares listed include the
       following: (i) 60,000 shares subject to stock options exercisable within
       60 days following November 30, 1998; (ii) 400 shares held in trust for
       the benefit of Mr. Mendelson's children, for which Mr. Mendelson's spouse
       is trustee; (iii) 13,385 shares held by CGCH&T Profit Sharing Trust FBO
       Mr. Mendelson (the "Mendelson Trust"); (vi) 5,143 shares held by Cooley
       Godward LLP, of which Mr. Mendelson is a partner; and (v) 2,154 shares
       issuable pursuant to warrants held in the Mendelson Trust.  Mr. Mendelson
       disclaims beneficial ownership of shares held in trust for the benefit of
       his children.  Mr. Mendelson also disclaims beneficial ownership of
       shares held by Cooley Godward LLP, except to the extent of his pecuniary
       interest therein.

(10)   Dr. Nichol is President, Chief Executive Officer and Chairman of the
       Board of the Company.  Shares listed include 257,500 shares subject to
       stock options exercisable within 60 days following November 30, 1998.

(11)   Dr. Rink is a director of the Company.  Shares listed include 64,000
       shares subject to stock options exercisable within 60 days following
       November 30, 1998.

(12)   Mr. Sears is a director of the Company.  Shares listed include the
       following:  (i) 145,500 shares held in The Sears Living Trust dated March
       11, 1991 (the "Sears Trust"); (ii) 85,916 shares subject to stock options
       exercisable within 60 days following November 30, 1998; and (iii) 4,000
       shares issuable pursuant to warrants held in the Sears Trust.

(13)   Dr. Weber is a director of the Company.  Shares listed include 173,799
       shares subject to stock options exercisable within 60 days following
       November 30, 1998.

(14)   Includes 988,292 shares subject to stock options exercisable within 60
       days following November 30, 1998 and 375,385 shares issuable pursuant to
       warrants held by directors or entities affiliated with such directors.
       See Notes (4) through (13) above.

                                       -15-
<PAGE>

                                   OTHER MATTERS

     The Board of Directors knows of no other matters that will be presented 
for consideration at the Special Meeting.  If any other matters are properly 
brought before the meeting, it is the intention of the persons named in the 
accompanying proxy to vote on such matters in accordance with their best 
judgment.

                                   By Order of the Board of Directors,




                                   ROBERT R. HOLMEN
                                   Secretary
December 30, 1998


A COPY OF THE COMPANY'S ANNUAL REPORT TO THE SECURITIES AND EXCHANGE 
COMMISSION ON FORM 10-K FOR THE YEAR ENDED DECEMBER 31, 1997 IS AVAILABLE 
WITHOUT CHARGE UPON WRITTEN REQUEST TO INVESTOR RELATIONS, COCENSYS, INC., 
201 TECHNOLOGY DRIVE, IRVINE, CA 92618.

                                       -16-
<PAGE>


                                     APPENDIX A

                               CERTIFICATE OF POWERS,
                  DESIGNATION, PREFERENCES, RIGHTS AND LIMITATIONS

                                         OF

                        SERIES E CONVERTIBLE PREFERRED STOCK

                                         OF

                                   COCENSYS, INC.

                          (Pursuant to Section 151 of the
                              General Corporation Law
                             of the State of Delaware)


     CoCensys, Inc., a corporation organized and existing under the General 
Corporation Law of the State of Delaware (the "Corporation"), hereby 
certifies that the following resolutions were adopted by the Board of 
Directors of the Corporation on April 20, 1998 pursuant to authority of the 
Board of Directors as required by Section 151(g) of the General Corporation 
Law of the State of Delaware:

     RESOLVED, that pursuant to the authority granted to and vested in the 
Board of Directors of this Corporation (the "Board of Directors" or the 
"Board") in accordance with the provisions of its Amended and Restated 
Certificate of Incorporation, the Board of Directors hereby authorizes and 
creates a series of the Corporation's previously authorized Preferred Stock, 
par value $.001 per share (the "Preferred Stock"), and hereby states the 
designation and number of shares, and fixes the relative rights, preferences, 
privileges, powers and restrictions thereof (in addition to the provisions 
set forth in the Amended and Restated Certificate of Incorporation of the 
Corporation, which are applicable to the Preferred Stock of all classes and 
series), as follows:

     Series E Convertible Preferred Stock:

                             I.  DESIGNATION AND AMOUNT

     Ten thousand (10,000) shares of Preferred Stock, $.001 par value are 
designated "Series E Convertible Preferred Stock" (the "Series E Preferred 
Stock") with the rights, preferences, privileges and restrictions specified 
in this Certificate of Powers, Designation, Preferences, Rights and 
Limitations (this "Certificate of Designation").  The stated value of the 
Series E Preferred Stock shall be One Thousand Dollars ($1,000) per share 
(the "Stated Value"). Subject to the provisions hereof, if the Second Closing 
(as defined in the Securities Purchase Agreement date as of June 8, 1998, by 
and between the Corporation and the other signatories thereto (the "Purchase 
Agreement")) does not occur, such number of shares of Preferred Stock 
designated Series E Preferred Stock may be decreased to eight thousand 
(8,000) by resolution of the Board of Directors.

                                      II.  RANK

     The Series E Preferred Stock shall rank (i) prior to the Corporation's 
common stock, par value $.001 per share (the "Common Stock"); (ii) prior to 
the Corporation's Series A Junior Participating Preferred Stock (the "Series 
A Preferred Stock"); (iii) prior to any class or series of capital stock of 
the Corporation hereafter created (unless, with the consent of the holders of 
Series E Preferred Stock obtained in accordance with Article IX hereof, such 
class or series of capital stock specifically, by its terms, ranks senior to 
or PARI PASSU with the Series E Preferred Stock) (collectively, with the 
Common Stock and the Series A Preferred Stock, "Junior Securities"); (iv) 

                                      A-1
<PAGE>

PARI PASSU with the Corporations' Series C Convertible Preferred Stock (the 
"Series C Preferred Stock") and Series D Convertible Preferred Stock (the 
"Series D Preferred Stock"); (v) PARI PASSU with any class or series of 
capital stock of the Corporation hereafter created (with the consent of the 
holders of Series E Preferred Stock obtained in accordance with Article IX 
hereof, unless the average Closing Bid Price (as defined below) for the ten 
(10) Trading Days (as defined below) ended one (1) Trading Day prior to the 
date on which the Board of Directors approves the issuance of such class or 
series of capital stock is above $4.00, in which case such consent will not 
be required) specifically ranking, by its terms, on parity with the Series E 
Preferred Stock (collectively, with the Series C Preferred Stock and Series D 
Preferred Stock, "PARI PASSU Securities"); and (vi) junior to any class or 
series of capital stock of the Corporation hereafter created (with the 
consent of the holders of Series E Preferred Stock obtained in accordance 
with Article IX hereof) specifically ranking, by its terms, senior to the 
Series E Preferred Stock ("Senior Securities"), in each case both as to the 
payment of dividends and as to distribution of assets upon liquidation, 
dissolution or winding up of the Corporation, whether voluntary or 
involuntary.

                                   III.  DIVIDENDS

     A.   PAYMENT OF DIVIDENDS.  The Series E Preferred Stock shall be 
entitled to cumulative dividends at the Applicable Dividend Rate (as defined 
below) from the date of issuance of the Series E Preferred Stock (the "Issue 
Date"), payable quarterly on March 31, June 30, September 30 and December 31 
(except that if any such date is a Saturday, Sunday or legal holiday, then 
such dividend shall be payable on the next succeeding day that is not a 
Saturday, Sunday or legal holiday) (each, a "Dividend Payment Date") to the 
holders of record of the Series E Preferred Stock.  Dividends shall accrue 
daily without interest from the Issue Date whether or not such dividends are 
declared by the Board of Directors and actually paid to the holders of Series 
E Preferred Stock as they appear on the stock books of the Corporation on 
such record dates, not more than twenty (20) nor less than ten (10) days 
preceding the Dividend Payment Dates for such dividends, as shall be fixed by 
the Board.  Accrued and unpaid dividends shall be payable to each holder of 
Series E Preferred Stock in cash, in whole but not in part, on the applicable 
Dividend Payment Date or, subject to the limitations of Article VI.A(c) and 
Article VI.E, at the sole option of the Corporation, shall be added to the 
Conversion Amount (as defined in Article VI.A) in accordance with Article 
VI.A; PROVIDED, HOWEVER, if the Corporation fails to timely pay all accrued 
and unpaid dividends in cash on the applicable Dividend Payment Date, the 
unpaid amount shall be automatically added to the Conversion Amount effective 
on the day following the applicable Dividend Payment Date.

     B.   DIVIDENDS ON JUNIOR SECURITIES.  In no event, so long as any Series 
E Preferred Stock shall remain outstanding, shall any dividend whatsoever be 
declared or paid upon, nor shall any distribution be made upon, any Junior 
Securities, nor shall any shares of Junior Securities be purchased or 
redeemed by the Corporation (other than the Series A Preferred Stock in 
accordance with Section 23 of the Rights Agreement dated May 15, 1995 between 
the Corporation and American Stock Transfer & Trust Company) nor shall any 
moneys be paid to or made available for a sinking fund for the purchase or 
redemption of any Junior Securities (other than a distribution of Junior 
Securities), without, in each such case, the written consent of the holders 
of a majority of the outstanding shares of Series E Preferred Stock, voting 
together as a class.

     C.   APPLICABLE DIVIDEND RATE.  The "Applicable Dividend Rate" shall 
mean 7.5%; PROVIDED, HOWEVER that if the Closing Price (as defined below) of 
the Common Stock is greater than or equal to (i) $4.05 for ten (10) 
consecutive Trading Days (as defined below), the Applicable Dividend Rate 
shall mean 5.5%, (ii) if the Closing Price of the Common Stock is greater 
than or equal to $4.95 for ten (10) consecutive Trading Days, the Applicable 
Dividend Rate shall mean 3.5% and (iii) if the Closing Price is greater than 
or equal to $6.00 for ten (10) consecutive Trading Days, the Applicable 
Dividend Rate shall mean 1.5%, in each case from and after the Trading Day on 
which, but only so long as, such price threshold is met.  Dividends shall 
accrue at the then Applicable Dividend Rate until such time as the condition 
thereto is no longer met (i.e., the price drops below the applicable 
threshold for ten (10) consecutive Trading Days) or at such time as a new 
Applicable Dividend Rate becomes effective, at which time dividends will 
begin to accrue at the new Applicable Dividend Rate.

                                      A-2
<PAGE>

     D.   LIQUIDATION EVENTS.  Any reference to "distribution" contained in 
this Article IV shall not be deemed to include distributions made in 
connection with any liquidation, dissolution or winding up of the 
Corporation, whether voluntary or involuntary.

                             IV.  LIQUIDATION PREFERENCE

     A.   LIQUIDATION EVENTS.  In the event of any liquidation, dissolution 
or winding up of the Corporation, either voluntary or involuntary (each such 
event being considered a "Liquidation Event"), the holders of the Series E 
Preferred Stock shall be entitled to receive, prior and in preference to any 
distribution of any of the assets or surplus funds of the Corporation to the 
holders of Junior Securities, the Liquidation Preference (as defined below) 
per share of Series E Preferred Stock and no more; provided, however, that 
such rights shall accrue to the holders of Series E Preferred Stock only in 
the event that the Corporation's payments with respect to the liquidation 
preference of the holders of any Senior Securities are fully met.  After the 
liquidation preferences of any Senior Securities are fully met, the entire 
assets of the Corporation available for distribution shall be distributed 
ratably among the holders of the Series E Preferred Stock and Pari Passu 
Securities in proportion to the respective preferential amounts to which each 
is entitled (but only to the extent of such preferential amounts).  If upon 
the occurrence of a Liquidation Event, the assets and funds available for 
distribution among the holders of the Series E Preferred Stock and holders of 
PARI PASSU Securities shall be insufficient to permit the payment to such 
holders of the full aforesaid preferential amounts payable thereon, then the 
entire assets and funds of the Corporation legally available for distribution 
to the Series E Preferred Stock and the PARI PASSU Securities shall be 
distributed ratably among such shares in proportion to the ratio that the 
Liquidation Preference payable on each such share bears to the aggregate 
liquidation preference payable on all such shares. After payment in full of 
the Liquidation Preference on the shares of Series E Preferred Stock and the 
liquidation preference on the PARI PASSU Securities, the holders of such 
shares shall not be entitled to any further participation in any distribution 
of assets by the Corporation.

     B.   EVENTS DEEMED LIQUIDATION EVENTS.  At the option of any holder of 
Series E Preferred Stock, the sale, conveyance or disposition of all or 
substantially all of the assets of the Corporation, the effectuation by the 
Corporation of a transaction or series of related transactions in which more 
than 50% of the voting power of the Corporation is disposed of, or the 
consolidation, merger or other business combination of the Corporation with 
or into any other Person (as defined below) or Persons when the Corporation 
is not the survivor (a "Change of Control Transaction") shall either: (i) be 
deemed to be a liquidation, dissolution or winding up of the Corporation 
pursuant to which the Corporation shall be required to distribute upon 
consummation of such transaction an amount equal to 125% of the Liquidation 
Preference with respect to each outstanding share of Series E Preferred Stock 
in accordance with and subject to the terms of this Article IV or (ii) be 
treated pursuant to Article VI.C(b) hereof; PROVIDED, HOWEVER, that the 
Corporation shall have the option, on at least fifteen (15) days prior 
written notice to the holders of the Series E Preferred Stock (during which 
time the holders of the Series E Preferred Stock shall maintain the right to 
convert any or all of the Series E Preferred Stock in accordance with Article 
VI), to redeem the Series E Preferred Stock immediately prior to the 
consummation of any Change in Control Transaction at the Mandatory Redemption 
Amount (as defined below); and PROVIDED, FURTHER, HOWEVER, that where the 
Corporation undertakes such an event and plans to account for such event as a 
"pooling of interests" in accordance with generally accepted accounting 
principles, (a) no such distribution pursuant to clause (i) above will be 
available and such event will be treated pursuant to clause (ii) above where 
the value of the distribution that would have been received pursuant to 
clause (i) above would be less than the value of the Common Stock that would 
be received upon conversion of the Series E Preferred Stock in accordance 
with Article VI below treating the Trading Day (as defined below) immediately 
preceding the date of such distribution as the "Conversion Date" (as defined 
in Article VI.D(d)) and (b) no such distribution pursuant to clause (ii) 
above will be available and such event will be treated pursuant to clause (i) 
above where the value of the distribution that would have been received 
pursuant to clause (i) above would be more than the value of the Common Stock 
that would be received upon conversion of the Series E Preferred Stock in 
accordance with Article VI below treating the Trading Day (as defined below) 
immediately preceding the date of such distribution as the "Conversion Date" 
(as defined in Article VI.D(d)).  "Person" shall mean any individual, 
corporation, limited liability company, partnership, association, trust or 
other entity or organization.

                                      A-3
<PAGE>

     C.   LIQUIDATION PREFERENCE.  For purposes hereof, the "Liquidation 
Preference" with respect to a share of the Series E Preferred Stock shall 
mean an amount equal to the sum of (i) the Stated Value thereof plus (ii) all 
accrued and unpaid dividends for the period beginning on the Issue Date and 
ending on the date of final distribution to the holder thereof (prorated for 
any portion of such period).  The liquidation preference with respect to any 
PARI PASSU Securities shall be as set forth in the Certificate of Designation 
filed in respect thereof.

                                    V. REDEMPTION

     A.   MANDATORY REDEMPTION.  If any of the following events (each, a 
"Mandatory Redemption Event") shall occur:

          (i)  The Corporation fails to issue shares of Common Stock to the 
holders of Series E Preferred Stock upon exercise by the holders of their 
conversion rights in accordance with the terms of this Certificate of 
Designation (for a period of at least sixty (60) days if such failure is 
solely as  a result of the circumstances governed by the second paragraph of 
Article VI.F below and the Corporation is using all commercially reasonable 
efforts to authorize a sufficient number of shares of Common Stock as soon as 
practicable), fails to transfer or to cause its transfer agent to transfer 
(electronically or in certificated form) any certificate for shares of Common 
Stock issued to the holders upon conversion of the Series E Preferred Stock 
as and when required by this Certificate of Designation or the Registration 
Rights Agreement, dated as of June 8, 1998, by and among the Corporation and 
the other signatories thereto (the "Registration Rights Agreement"), fails to 
remove any restrictive legend (or to withdraw any stop transfer instructions 
in respect thereof) on any certificate or any shares of Common Stock issued 
to the holders of Series E Preferred Stock upon conversion of the Series E 
Preferred Stock as and when required by this Certificate of Designation, the 
Purchase Agreement or the Registration Rights Agreement, or fails to fulfill 
its obligations pursuant to Sections 4(c), 4(e), 4(h), 4(i), 4(j) or 5 of the 
Purchase Agreement (or makes any announcement, statement or threat that it 
does not intend to honor the obligations described in this paragraph) and any 
of the foregoing failures shall continue uncured (or any announcement, 
statement or threat not to honor its obligations shall not be rescinded in 
writing) for ten (10) business days;

          (ii) The Corporation fails to obtain effectiveness with the 
Securities and Exchange Commission (the "SEC") of the Registration Statement 
(as defined in the Registration Rights Agreement) prior to December 8, 1998 
or such Registration Statement lapses in effect (or sales otherwise cannot be 
made thereunder, whether by reason of the Corporation's failure to amend or 
supplement the prospectus included therein in accordance with the 
Registration Rights Agreement or otherwise) for more than forty-five (45) 
consecutive Trading Days (as defined below) or more than ninety (90) Trading 
Days in any twelve (12) month period or more than one hundred twenty (120) 
Trading Days during the Registration Period (as defined in the Registration 
Rights Agreement) after such Registration Statement becomes effective;

          (iii)     The Corporation shall make an assignment for the benefit 
of creditors, or apply for or consent to the appointment of a receiver or 
trustee for it or for all or substantially all of its property or business; 
or such a receiver or trustee shall otherwise  be appointed;

          (iv) Bankruptcy, insolvency, reorganization or liquidation 
proceedings or other proceedings for relief under any bankruptcy law or any 
law for the relief of debtors shall be instituted by or against the 
Corporation or any subsidiary of the Corporation; PROVIDED, HOWEVER, that in 
the case of any involuntary bankruptcy, such involuntary bankruptcy shall 
continue undischarged or undismissed for a period of sixty (60) days;

          (v)  The Corporation shall fail to maintain the listing of the Common
Stock on the Nasdaq National Market ("Nasdaq"), the Nasdaq SmallCap Market, the
New York Stock Exchange or the American Stock Exchange, then, upon the
occurrence and during the continuation of any Mandatory Redemption Event
specified in subparagraphs (i), (ii) or (v) at the option of each holder of the
then outstanding shares of Series E Preferred Stock by written notice (the
"Mandatory Redemption Notice") to the Corporation of such Mandatory Redemption
Event, or upon the occurrence of any Mandatory Redemption Event specified in
subparagraphs (iii) or (iv), the Corporation shall purchase such holder's shares
of Series E Preferred Stock for an amount per share equal to the greater of (1)

                                      A-4
<PAGE>

130% multiplied by the sum of (a) the Stated Value of the shares to be 
redeemed plus (b) all accrued and unpaid dividends for the period beginning 
on the Issue Date and ending on the date of payment of the Mandatory 
Redemption Amount (the "Mandatory Redemption Date"), and (2) the "parity 
value" of the shares to be redeemed, where parity value means the product of 
(a) the highest number of shares of Common Stock issuable upon conversion of 
such shares in accordance with Article VI below (without giving any effect to 
any limitations on conversions of shares set forth in Article VI.A(b) below, 
and treating the Trading Day (as defined in Article VI.B) immediately 
preceding the Mandatory Redemption Date as the "Conversion Date" (as defined 
in Article VI.B(a)) for purposes of determining the lowest applicable 
Conversion Price), unless the Mandatory Redemption Event arises as a result 
of a breach in respect of a specific Conversion Date in which case such 
Conversion Date shall be the Conversion Date), multiplied by (b) the Closing 
Price (as defined in Article VI.A(b)) for the Common Stock on such 
"Conversion Date" (the greater of such amounts being referred to as the 
"Mandatory Redemption Amount").  If there is a Mandatory Redemption Event 
specified in subparagraph (ii) and the holders of the Series E Preferred 
Stock do not elect to send a Mandatory Redemption Notice to the Corporation, 
then (i) the Automatic Conversion Date (as defined in Article VII) shall be 
extended for a period equal to 1.5 times the total number of days the 
Registration Statement lapsed in effect (or sales could not be made 
thereunder, whether by reason of the Corporation's failure to amend or 
supplement the prospectus included therein in accordance with the 
Registration Rights Agreement or otherwise) and (ii) the Applicable 
Percentage shall be reduced by 1% for each month in excess of the Allowed 
Delay (as defined in Section 3(f) of the Registration Rights Agreement) that 
the holders of Series E Preferred Stock are not permitted to sell the Common 
Stock pursuant to the Registration Statement in accordance with Section 2(c) 
of the Registration Rights Agreement.

     In the case of a Mandatory Redemption Event, if the Corporation fails to 
pay the Mandatory Redemption Amount for each share within five (5) business 
days of written notice that such amount is due and payable, then (assuming 
there are sufficient authorized shares) in addition to all other available 
remedies, each holder of Series E Preferred Stock shall have the right at any 
time, so long as the Mandatory Redemption Event continues, to require the 
Corporation, upon written notice, to immediately issue (in accordance with 
and subject to the terms of Article VI below), in lieu of the Mandatory 
Redemption Amount, with respect to each outstanding share of Series E 
Preferred Stock held by such holder, the number of shares of Common Stock of 
the Corporation equal to the Mandatory Redemption Amount divided by the 
average Closing Price of the Common Stock for the two (2) Trading Days prior 
to the date the holder provides notice to the Corporation of its election to 
receive Common Stock in lieu of the Mandatory Redemption Amount in accordance 
with this paragraph.

     B.   19.99% REDEMPTION.  If the Series E Preferred Stock ceases to be 
convertible as a result of the limitations described in Article VI.A(c) below 
(a "19.99% Redemption Event"), and the Corporation has not prior to, or 
within thirty (30) days of, the date that such 19.99% Redemption Event 
arises, (i) obtained approval of the issuance of the additional shares of 
Common Stock by the requisite vote of the holders of the then-outstanding 
Common Stock (not including any shares of Common Stock held by present or 
former holders of Series E Preferred Stock that were issued upon conversion 
of Series E Preferred Stock) or (ii) received other permission pursuant to 
Nasdaq Rule 4460(i) allowing the Corporation to resume issuances of shares of 
Common Stock upon conversion of Series E Preferred Stock, then the 
Corporation shall be obligated to redeem immediately all of the then 
outstanding Series E Preferred Stock, in accordance with this Article V.B.  
An irrevocable redemption notice (the "Redemption Notice") shall be delivered 
promptly to the holders of Series E Preferred Stock at their registered 
address appearing on the records of the Corporation and shall state (1) that 
19.99% of the Outstanding Common Amount (as defined in Article VI.A) has been 
issued upon exercise of the Series E Preferred Stock, (2) that the 
Corporation is obligated to redeem all of the outstanding Series E Preferred 
Stock and (3) the Mandatory Redemption Date, which shall be a date within 
five (5) business days of the earlier of (i) the date of the Redemption 
Notice or (ii) the date on which the holders of the Series A Preferred Stock 
notify the Corporation of the occurrence of a 19.99% Redemption Event.  On 
the Mandatory Redemption Date, the Corporation shall make payment in cash of 
an amount equal to 110% times the product of (a) the number of shares of 
Common Stock issuable upon conversion of the shares of Series E Preferred 
Stock being redeemed pursuant to this Article V.B and as determined in 
accordance with Article VI below (without giving any effect to any 
limitations on conversions of shares set forth in Article VI.A(b) below, and 
treating the Trading Day (as defined in Article VI.B) immediately preceding 
the Mandatory Redemption Date as the "Conversion Date" (as defined in Article 
VI.B(a)) multiplied by (b) the Closing Price (as defined in Article VI.A(b)) 
of the Common Stock on such Conversion Date.

                                      A-5
<PAGE>

                     VI.  CONVERSION AT THE OPTION OF THE HOLDER

     A.   OPTIONAL CONVERSION

          (a)  CONVERSION AMOUNT.  Subject to the conversion restrictions set 
forth in Article VI.A(b) below, each holder of shares of Series E Preferred 
Stock may, at its option at any time and from time to time, upon surrender of 
the certificates therefor, convert any or all of its shares of Series E 
Preferred Stock into Common Stock as follows (an "Optional Conversion").  A 
minimum of (10) shares of Series E Preferred Stock shall be surrendered for 
each Optional Conversion (or such lesser amount if a holder of Series E 
Preferred Stock owns less than ten (10) shares of Series E Preferred Stock).  
Each share of Series E Preferred Stock shall be convertible into such number 
of fully paid and nonassessable shares of Common Stock as is determined by 
dividing (1) the Conversion Amount (as defined below), by (2) the then 
effective Conversion Price (as defined below); PROVIDED, HOWEVER, that, 
unless the holder delivers a waiver in accordance with the immediately 
following sentence, in no event (other than pursuant to the Automatic 
Conversion (as defined herein)) shall a holder of shares of Series E 
Preferred Stock be entitled to convert any such shares in excess of that 
number of shares upon conversion of which the sum of (x) the number of shares 
of Common Stock beneficially owned by the holder and its affiliates (other 
than shares of Common Stock which may be deemed beneficially owned through 
the ownership of the unconverted portion of the shares of Series E Preferred 
Stock) and (y) the number of shares of Common Stock issuable upon the 
conversion of the shares of Series E Preferred Stock with respect to which 
the determination of this proviso is being made, would result in beneficial 
ownership by a holder and such holder's affiliates of more than 4.9% of the 
outstanding shares of Common Stock.  For purposes of the proviso to the 
immediately preceding sentence, (i) beneficial ownership shall be determined 
in accordance with Section 13(d) of the Securities Exchange Act of 1934, as 
amended, and Regulation 13D-G thereunder, except as otherwise provided in 
clause (x) of such proviso and (ii) a holder may waive the limitations set 
forth therein by written notice to the Corporation upon not less than 
sixty-one (61) days prior written notice (with such waiver taking effect only 
upon the expiration of such sixty-one (61) day notice period).  The 
"Conversion Amount" means the sum of (a) the Stated Value of the shares of 
Series E Preferred Stock issued for conversion plus (b) the Unpaid Dividend 
Amount where the "Unpaid Dividend Amount" means the Applicable Dividend Rate 
TIMES the Stated Value of the shares of Series E Preferred Stock issued for 
conversion times N/365 where N equals the number of days since the later of 
(x) the Issue Date or (y) the last Dividend Payment Date on which the 
Corporation paid the then accrued and unpaid dividends in cash; PROVIDED, 
HOWEVER that the Corporation shall have the option to pay the Unpaid Dividend 
Amount in cash, in whole but not in part, by wire transfer to the account of 
the holder of Series E Preferred Stock issued for conversion simultaneously 
with the delivery of the shares of Common Stock issued upon such conversion, 
in which event the Conversion Amount shall equal the Stated Value of the 
shares of Series E Preferred Stock issued for conversion.

          (b)  CONVERSION RESTRICTIONS.

               (i)  CONVERSION RESTRICTION PERIOD.  For the period beginning 
on the Issue Date and ending on October 8, 1998, (the "Conversion Restriction 
Period"), if the Common Stock trades on Nasdaq or the principal trading 
market on which the Common Stock is then listed is less than $4.00 per share 
for ten (10) consecutive Trading Days, the holders of Series E Preferred 
Stock thereafter during the reminder of the Conversion Restriction Period 
shall only be permitted to convert, in the aggregate, into a number of shares 
of Common Stock that is less than or equal to the greater of (a) 15% of the 
trading volume for the calendar month in which conversions are taking place 
or (b) 15% of the trading volume for the calendar month prior to the calendar 
month in which the conversions are taking place (such lesser amount is 
hereinafter referred to as the "Conversion Restriction Amount").  
Notwithstanding the preceding sentence, if the Common Stock thereafter trades 
on Nasdaq or the principal trading market on which the Common Stock is then 
listed above $4.00 per share for ten (10) consecutive Trading Days during the 
Conversion Restriction Period, the conversion limitations set forth in the 
preceding sentence shall forever cease to be applicable.  The  Conversion 
Restriction Amount (i) shall be allocated pro rata in accordance with Article 
X below and (ii) shall not include shares issued upon conversions taking 
place prior to the trigger date of the restriction.

                                      A-6
<PAGE>

               (ii) ADJUSTMENT PERIOD.  By written notice to the holders 
delivered by 4:30 p.m. on any Trading Day, the Corporation shall be permitted 
to suspend the right to convert shares of Series E Preferred Stock on the 
next Trading Day after any Trading Day that the Closing Price of the Common 
Stock on Nasdaq or the principal trading market on which the Common Stock is 
then listed is less than $2.00 per share unless on such next Trading Day, the 
Common Stock trades on Nasdaq or the principal trading market on which the 
Common Stock is then listed above $2.00 prior to 12:00 noon on such Trading 
Day.  If the Closing Price of the Common Stock remains below $2.00 per share 
for twenty (20) consecutive Trading Days (the "Adjustment Period"), whether 
or not the Corporation has restricted conversions for some or all of such 
days, the Corporation shall either:  (i) forever waive the foregoing right to 
restrict conversions and allow the holders of the Series E Preferred Stock to 
convert their shares of Series E Preferred Stock; (ii) purchase each holder's 
shares of Series E Preferred Stock for an amount (the "Optional Redemption 
Amount") per share equal to 125% multiplied by the sum of (a) the Stated 
Value of the shares to be redeemed plus (b) all accrued and unpaid dividends 
for the period beginning on the Issue Date and ending on the date of payment 
of the Optional Redemption Amount; or (iii) adjust the exercise price of 
one-half of the warrants issued pursuant to the Securities Purchase Agreement 
(the "Warrants") that have not been exercised prior to the last day of the 
Adjustment Period to the lowest trading price during the Adjustment Period.  
In the event that the Corporation elects to adjust the exercise price of the 
Warrants pursuant to clause (iii) of the preceding sentence, (x) the holders 
of Series E Preferred Stock thereafter shall not be permitted to convert 
shares of Series E Preferred Stock thereafter on any Trading Day that the 
Common Stock trades below the average Closing Price of the Common Stock 
during the Adjustment Period (the "New Floor") and (y) if after such 
election, the Common Stock trades below the New Floor for twenty (20) 
consecutive Trading Days (the "Second Adjustment Period"), the Corporation 
shall either (i) adjust the Exercise Price of the remaining half of the 
Warrants to the lowest trading price of the Common Stock during the Second 
Adjustment Period or (ii) select either of the options set forth in clauses 
(i) and (ii) of the second sentence of this paragraph.  In the event that the 
Corporation elects to adjust the exercise price of the Warrants pursuant to 
clause (i) of the preceding sentence, the holders of Series E Preferred Stock 
thereafter shall not be permitted to convert shares of Series E Preferred 
Stock on any Trading Day in which the Common Stock trades below the average 
Closing Price of the Common Stock during the Second Adjustment Period; 
PROVIDED, HOWEVER, that this prohibition shall terminate when the number of 
Trading Days during which it applies, together with the number of Trading 
Days during which conversions have otherwise been restricted under this 
Article VI.A(b)(ii) equals forty (40) Trading Days in any twelve (12) month 
period. "Closing Price," as of any date, means the last sale price of the 
Common Stock on the Nasdaq as reported by Bloomberg Financial Markets or an 
equivalent reliable reporting service mutually acceptable to and hereafter 
designated by the holders of a majority in interest of the shares of Series E 
Preferred Stock and the Corporation ("Bloomberg") or, if Nasdaq is not the 
principal trading market for such security, the last sale price of such 
security on the principal securities exchange or trading market where such 
security is listed or traded as reported by Bloomberg, or if the foregoing do 
not apply, the last sale price of such security in the over-the-counter 
market on the electronic bulletin board for such security as reported by 
Bloomberg, or, if no last sale price of such security is available in the 
over-the-counter market on the electronic bulletin board for such security or 
in any of the foregoing manners the average of the bid prices of any market 
makers for such security that are listed in the "pink sheets" by the National 
Quotation Bureau, Inc.  If the Closing Price cannot be calculated for such 
security on such date in the manner provided above, the Closing Price shall 
be the fair market value as mutually determined by the Corporation and the 
holders of a majority in interest of shares of Series E Preferred Stock being 
converted for which the calculation of the Closing Price is required in order 
to determine the Conversion Price of such Series E Preferred Stock.

               (iii)     INAPPLICABILITY OF CONVERSION RESTRICTIONS.  The 
restrictions on conversion set forth in this Article VI.A(b) shall not apply 
to conversions taking place on any Conversion Date (i) occurring on or after 
the date the Corporation makes a public announcement that it intends to merge 
or consolidate with any other corporation or sell or transfer substantially 
all of the assets of the Corporation or (ii) occurring on or after the date 
any person, group or entity (including the Corporation) publicly announces a 
tender offer to purchase 50% or more of the Corporation's Common Stock or 
otherwise publicly announces an intention to replace a majority of the 
Corporation's Board of Directors by waging a proxy battle or otherwise or 
(iii) occurring on or after there is a material adverse change in the 
business, operation, assets, financial condition or prospects of the 
Corporation or its subsidiaries, taken as a whole.

                                      A-7
<PAGE>

          (c)  NASDAQ LIMITATIONS ON CONVERSION.  So long as the Common Stock 
is listed for trading on Nasdaq or an exchange or quotation system with a 
rule substantially similar to Rule 4460(i) then, notwithstanding anything to 
the contrary contained herein if, at any time, the aggregate number of shares 
of Common Stock then issued upon conversion of the Series E Preferred Stock 
(including any shares of capital stock or rights to acquire shares of capital 
stock issued by the Corporation which are aggregated or integrated with the 
Common Stock issued or issuable upon conversion of the Series E Preferred 
Stock for purposes of such rule) equals 19.99% of the "Outstanding Common 
Amount" (as hereinafter defined), the Series E Preferred Stock shall, from 
that time forward, cease to be convertible into Common Stock in accordance 
with the terms of this Article VI and Article VII below, unless the 
Corporation (i) has obtained approval of the issuance of the Common Stock 
upon conversion of the Series E Preferred Stock by a majority of the total 
votes cast on such proposal, in person or by proxy, by the holders of the 
then-outstanding Common Stock (not including any shares of Common Stock held 
by present or former holders of Series E Preferred Stock that were issued 
upon conversion of Series E Preferred Stock) (the "Stockholder Approval"), or 
(ii) shall have otherwise obtained permission to allow such issuances from 
Nasdaq in accordance with Nasdaq Rule 4460(i).  If the Corporation's Common 
Stock is not then listed on Nasdaq or an exchange or quotation system that 
has a rule substantially similar to Rule 4460(i) then the limitations set 
forth herein shall be inapplicable and of no force and effect. For purposes 
of this paragraph, "Outstanding Common Amount" means (i) the number of shares 
of the Common Stock outstanding on the date of issuance of the Series E 
Preferred Stock pursuant to the Purchase Agreement plus (ii) any additional 
shares of Common Stock issued thereafter in respect of such shares pursuant 
to a stock dividend, stock split or similar event.  The maximum number of 
shares of Common Stock issuable as a result of the 19.99% limitation set 
forth herein is hereinafter referred to as the "Maximum Share Amount."  With 
respect to each holder of Series E Preferred Stock, the Maximum Share Amount 
shall refer to such holder's PRO RATA share thereof determined in accordance 
with Article X below. In the event that Corporation obtains Stockholder 
Approval or the approval of Nasdaq, by reason of the inapplicability of the 
rules of Nasdaq or otherwise and concludes that it is able to increase the 
number of shares to be issued above the Maximum Share Amount (such increased 
number being the "New Maximum Share Amount"), the references to Maximum Share 
Amount, above, shall be deemed to be, instead, references to the greater New 
Maximum Share Amount.  In the event that Stockholder Approval is obtained but 
there are insufficient reserved or authorized shares or a registration 
statement covering the additional shares of Common Stock which constitute the 
New Maximum Share Amount is not effective prior to the Maximum Share Amount 
being issued (if such registration statement is necessary to allow for the 
public resale of such securities), the Maximum Share Amount shall remain 
unchanged; PROVIDED, HOWEVER, that the holders of the Series E Preferred 
Stock may grant an extension of the redemption required pursuant to Article 
V.B to allow the Corporation to obtain a sufficient reserved or authorized 
amount of shares or of the effective date of such registration statement.  In 
the event that (a) the aggregate number of shares of Common Stock actually 
issued upon conversion of the Series E Preferred Stock represents at least 
twenty percent (20%) of the Maximum Share Amount and (b) the sum of (x) the 
aggregate number of shares of Common Stock actually issued upon conversion of 
the outstanding Series E Preferred Stock PLUS (y) the aggregate number of 
shares of Common Stock that remain issuable upon conversion of Series E 
Preferred Stock, represents at least one hundred percent (100%) of the 
Maximum Share Amount (the "Triggering Event"), the Corporation will use its 
best efforts to seek and obtain Stockholder Approval (or obtain such other 
relief as will allow conversions hereunder in excess of the Maximum Share 
Amount) as soon as practicable following the Triggering Event and before the 
Mandatory Redemption Date.

                                      A-8
<PAGE>

     B.   CONVERSION PRICE.

          (a)  CALCULATION OF CONVERSION PRICE.  Subject to subparagraph (b) 
below, the "Conversion Price" shall be the lesser of the Market Price (as 
defined herein) and the Fixed Conversion Price (as defined herein), subject 
to adjustments pursuant to the provisions of Article VI.C below.  "Market 
Price" shall mean the Applicable Percentage (as defined below) times the 
average of the three (3) Lowest Trading Prices (as defined below) during the 
fifteen (15) Trading Day period ending one (1) Trading Day prior to the date 
(the "Conversion Date") the Notice of Conversion (as defined in Article VI.E) 
is sent by a holder to the Corporation via facsimile (the "Pricing Period").  
"Fixed Conversion Price" shall mean $3.93.  "Lowest Trading Price" means, for 
any security as of any date, the low trade price on Nasdaq as reported by 
Bloomberg or, if Nasdaq is not the principal trading market for such 
security, the low trade price of such security on the principal securities 
exchange or trading market where such security is listed or traded as 
reported by Bloomberg, or if the foregoing do not apply, the low trade price 
of such security can be determined in the over-the-counter market on the 
electronic bulletin board for such security as reported by Bloomberg, or, if 
no trade price of such security is available in the over-the-counter market 
on the electronic bulletin board for such security or in any of the foregoing 
manners, the average of the lowest bid prices of any market makers for such 
security that are listed in the "pink sheets" by the National Quotation 
Bureau, Inc.  If the Lowest Trading Price cannot be calculated for such 
security on such date in the manner provided above, the Lowest Trade Price 
shall be the low range of the fair market value as mutually determined by the 
Corporation and the holders of a majority in interest of shares of Series E 
Preferred Stock being converted for which the calculation of the Lowest Trade 
Price is required in order to determine the Conversion Price of such Series E 
Preferred Stock.  "Applicable Percentage" shall mean 100% from the Issue Date 
until October 8, 1998 and 90% thereafter, subject to adjustment pursuant to 
Section 2(c) of the Registration Rights Agreement.  "Trading Day" shall mean 
any day on which the Common Stock is traded for any period on Nasdaq, or on 
the principal securities exchange or other securities market on which the 
Common Stock is then being traded.

          (b)  Notwithstanding anything contained in subparagraph (a) of this 
Paragraph B to the contrary, in the event the Corporation (i) makes a public 
announcement  that it intends to consolidate or merge with any other 
corporation (other than a merger in which the Corporation is the surviving or 
continuing corporation and its capital stock is unchanged) or sell or 
transfer all or substantially all of the assets of the Corporation or (ii) 
any person, group or entity (including the Corporation) publicly announces a 
tender offer to purchase 50% or more of the Corporation's Common Stock or 
otherwise publicly announces an intention to replace a majority of the 
corporation's Board of Directors by waging a proxy battle or otherwise (the 
date of the announcement referred to in clause (i) or (ii) is hereinafter 
referred to as the "Announcement Date"), then the Conversion Price shall, 
effective upon the Announcement Date and continuing through the Adjusted 
Conversion Price Termination Date (as defined below), be equal to the lower 
of (x) the Conversion Price which would have been applicable for an Optional 
Conversion occurring on the Announcement Date and (y) the Conversion Price 
that would otherwise be in effect. From and after the Adjusted Conversion 
Price Termination Date, the Conversion Price shall be determined as set forth 
in subparagraph (a) of this Article VI.B.  For purposes hereof, "Adjusted 
Conversion Price Termination Date" shall mean, with respect to any proposed 
transaction, tender offer or removal of the majority of the Board of 
Directors which a public announcement as contemplated by this subparagraph 
(b) has been made, the date upon which the Corporation (in the case of clause 
(i) above) or the person, group or entity (in the case of clause (ii) above) 
consummates or publicly announces the termination or abandonment of the 
proposed transaction or tender offer which caused this subparagraph (b) to 
become operative.

     C.   ADJUSTMENTS TO CONVERSION PRICE.  The Conversion Price shall be 
subject to adjustment from time to time as follows:

          (a)  ADJUSTMENT TO CONVERSION PRICE DUE TO STOCK SPLIT, STOCK 
DIVIDEND, ETC.  If at any time when Series E Preferred Stock is issued and 
outstanding, the number of outstanding shares of Common Stock is increased or 
decreased by a stock split, stock dividend, combination, reclassification, 
rights offering below the Adjustment Trading Price (as defined below) to all 
holders of Common Stock or other similar event, which event shall have taken 
place during the reference period for determination of the Conversion Price 
for any Optional Conversion or Automatic Conversion of the Series E Preferred 
Stock, then the Conversion Price shall be calculated giving appropriate 
effect to the stock split, stock dividend, combination, reclassification or 
other similar event.  In 

                                      A-9
<PAGE>

such event, the Corporation shall notify its Transfer Agent of such change on 
or before the effective date thereof.  "Adjustment Trading Price," which 
shall be measured as of the record date in respect of the rights offering, 
means (i) the average of the last reported sale prices for the shares of 
Common Stock on Nasdaq as reported by Bloomberg, as applicable, for the five 
(5) Trading Days immediately preceding such date, or (ii) if Nasdaq is not 
the principal trading market for the shares of Common Stock, the average of 
the last reported sale prices on the principal trading market for the Common 
Stock during the same period as reported by Bloomberg, or (iii) if market 
value cannot be calculated as of such date on any of the foregoing bases, the 
Adjustment Trading Price shall be the fair market value as reasonably 
determined in good faith by (a) the Board of Directors of the Corporation or, 
(b) at the option of a majority-in-interest of the holders of the outstanding 
Series E Preferred Stock by an independent investment bank of nationally 
recognized standing in the valuation of businesses similar to the business of 
the Corporation.

          (b)  ADJUSTMENT DUE TO MERGER, CONSOLIDATION, ETC.  If, at any time 
when Series E Preferred Stock is issued and outstanding and prior to the 
conversion of all Series E Preferred Stock, there shall be any merger, 
consolidation, exchange of shares, recapitalization, reorganization, or other 
similar event, as a result of which shares of Common Stock of the Corporation 
shall be changed into the same or a different number of shares of another 
class or classes of stock or securities of the Corporation or another entity, 
or in case of any sale or conveyance of all or substantially all of the 
assets of the Corporation other than in connection with a plan of complete 
liquidation of the Corporation, then the holders of Series E Preferred Stock 
shall thereafter have the right to receive upon conversion of the Series E 
Preferred Stock, upon the bases and upon the terms and conditions specified 
herein and in lieu of the shares of Common Stock immediately theretofore 
issuable upon conversion, such stock, securities or assets which the holders 
of Series E Preferred Stock would have been entitled to receive in such 
transaction had the Series E Preferred Stock been converted in full (without 
regard to any limitations on conversion contained herein) immediately prior 
to such transaction, and in any such case appropriate provisions shall be 
made with respect to the rights and interests of the holders of Series E 
Preferred Stock to the end that the provisions hereof (including, without 
limitation, provisions for adjustment of the Conversion Price and of the 
number of shares of Common Stock issuable upon conversion of the Series E 
Preferred Stock) shall thereafter be applicable, as nearly as may be 
practicable in relation to any securities or assets thereafter deliverable 
upon the conversion of Series E Preferred Stock.  The Corporation shall not 
effect any transaction described in this subsection (b) unless (a) it first 
gives, to the extent practical, twenty (20) days' prior written notice (but 
in any event at least ten (10) business days prior written notice) of such 
merger, consolidation, exchange of shares, recapitalization, reorganization  
or other similar event or sale of assets (during which time the holders of 
Series E Preferred Stock shall be entitled to convert the Series E Preferred 
Stock) and (b) the resulting successor or acquiring entity (if not the 
Corporation) assumes by written instrument the obligations of this subsection 
(b).  The above provisions shall similarly apply to successive 
consolidations, mergers, sales, transfers or share exchanges.

          (c)  OTHER SECURITIES OFFERINGS.  If, at any time after the Issue 
Date and prior to June 8, 1999, the Corporation sells Common Stock or 
securities convertible into, or exchangeable for, Common Stock, other than 
(i) a sale pursuant to a bona fide firm commitment underwritten public 
offering of Common Stock by the Corporation (not including a continuous 
offering pursuant to Rule 415 under the Securities Act of 1933, as amended), 
(ii) a sale as consideration for a merger, consolidation or purchase of 
assets, (iii) a sale in connection with any strategic partnership or joint 
venture (the primary purpose of which is not to raise equity capital) or (iv) 
a sale to Sanderling Ventures and its affiliates, Domain Associates and its 
affiliates, Innocal, Abingworth Bioventures and its affiliates, Rothchild 
Asset Management, Dimensional Fund Advisors, Inc.or New York Life Insurance  
(collectively, the "Other Common Stock"), then, if the effective or maximum 
sales price of the Common Stock with respect to such transaction (including 
the effective or maximum conversion, or exchange price) ("Other Price") is 
less than the effective Conversion Price of the Series E Preferred Stock at 
such time, the Corporation shall adjust the Conversion Price applicable to 
the Series E Preferred Stock not yet converted in form and substance 
reasonably satisfactory to the holders of Series E Preferred Stock so that 
the Conversion Price applicable to the Series E Preferred Stock shall not, in 
any event, be greater, after giving effect to all other adjustments contained 
herein, than the Other Price.

          (d)  ADJUSTMENT DUE TO DISTRIBUTION.  Subject to Article III, if 
the Corporation shall declare or make any distribution of its assets (or 
rights to acquire its assets) to holders of Common Stock as a dividend, stock 
repurchase, by way of return of capital or otherwise (including any dividend 
or distribution to the Corporation's 

                                     A-10
<PAGE>

stockholders in cash or shares (or rights to acquire shares) of capital stock 
of a subsidiary (i.e., a spin-off)) (a "Distribution"), then the holders of 
Series E Preferred Stock shall be entitled, upon any conversion of shares of 
Series E Preferred Stock after the date of record for determining 
stockholders entitled to such Distribution, to receive the amount of such 
assets which would have been payable to the holder with respect to the shares 
of Common Stock issuable upon such conversion had such holder been the holder 
of such shares of Common Stock on the record date for the determination of 
stockholders entitled to such Distribution.

          (e)  PURCHASE RIGHTS.  Subject to Article III, if at any time when 
any Series E Preferred Stock is issued and outstanding, the Corporation 
issues any convertible securities or rights to purchase stock, warrants, 
securities or other property (the "Purchase Rights") pro rata to the record 
holders of any class of Common Stock, then the holders of Series E Preferred 
Stock will be entitled to acquire, upon the terms applicable to such Purchase 
Rights, the aggregate Purchase Rights which such holder could have acquired 
if such holder had held the number of shares of Common Stock acquirable upon 
complete conversion of the Series E Preferred Stock (without regard to any 
limitations on conversion contained herein) immediately before the date on 
which a record is taken for the grant, issuance or sale of such Purchase 
Rights, or, if no such record is taken, the date as of which the record 
holders of Common Stock are to be determined for the grant, issue or sale of 
such Purchase Rights.

          (f)  ADJUSTMENT FOR RESTRICTED PERIODS.  In the event that (1) the 
Corporation fails to obtain effectiveness with the Securities and Exchange 
Commission of the Registration Statement (as defined in the Registration 
Rights Agreement) on or prior to ninety (90) days following the Issue Date, 
or (2) such Registration Statement lapses in effect, or sales otherwise 
cannot be made thereunder, whether by reason of the Corporation's failure or 
inability to amend or supplement the prospectus (the "Prospectus") included 
therein in accordance with the Registration Rights Agreement or otherwise, 
after such Registration Statement becomes effective (including, without 
limitation, during an Allowed Delay (as defined in Section 3(f) of the 
Registration Rights Agreement) or a Permitted Offering Delay (as defined in 
Section 3(g) of the Registration Rights Agreement)), then the Pricing Period 
shall be comprised of, (i) in the case of an event described in clause (1), 
the fifteen (15) Trading Days preceding the 90th day following the Issue Date 
plus all Trading Days through and including the third Trading Day following 
the date of effectiveness of the Registration Statement; and (ii) in the case 
of an event described in clause (2), the fifteen (15) Trading Days preceding 
the date on which the holder of the Series E Preferred Stock is first 
notified that sales may not be made under the Prospectus, plus all Trading 
Days through and including the third Trading Day following the date on which 
the Holder is first notified that such sales may again be made under the 
Prospectus.  If a holder of Series E Preferred Stock determines that sales 
may not be made pursuant to the Prospectus (whether by reason of the 
Corporation's failure or inability to amend or supplement the Prospectus or 
otherwise) it shall so notify the Corporation in writing and, unless the 
Corporation provides such holder with a written opinion of the Corporation's 
counsel to the contrary, such determination shall be binding for purposes of 
this paragraph.

          (g)  NOTICE OF ADJUSTMENTS.  Upon the occurrence of each adjustment 
or readjustment of the Conversion Price pursuant to this Article VI.C, the 
Corporation, at its expense, shall promptly compute such adjustment or 
readjustment and prepare and furnish to each holder of Series E Preferred 
Stock a certificate setting forth such adjustment or readjustment and showing 
in detail the facts upon which such adjustment or readjustment is based.  The 
Corporation shall, upon the written request at any time of any holder of 
Series E Preferred Stock, furnish to such holder a like certificate setting 
forth (i) such adjustment or readjustment, (ii) the Conversion Price at the 
time in effect and (iii) the number of shares of Common Stock and the amount, 
if any, of other securities or property which at the time would be received 
upon conversion of a share of Series E Preferred Stock.

     D.   MECHANICS OF CONVERSION.  In order to convert Series E Preferred 
Stock into full shares of Common Stock, a holder of Series E Preferred Stock 
shall: (i) submit a copy of the fully executed notice of conversion in the 
form attached hereto as Exhibit A ("Notice of Conversion") to the Corporation 
by facsimile dispatched on the Conversion Date (or by other means resulting 
in, or reasonably expected to result in, notice to the Corporation on the 
Conversion Date) at the office of the Corporation or its designated Transfer 
Agent for the Series E Preferred Stock that the holder elects to convert the 
same, which notice shall specify the number of shares of Series E Preferred 
Stock to be converted, the applicable Conversion Price and a calculation of 
the number of shares of Common Stock issuable upon such conversion (together 
with a copy of the first page of each certificate to be 

                                     A-11
<PAGE>

converted) prior to Midnight, New York City time (the "Conversion Notice 
Deadline") on the date of conversion specified on the Notice of Conversion; 
and (ii) surrender the original certificates representing the Series E 
Preferred Stock being converted (the "Preferred Stock Certificates"), duly 
endorsed, along with a copy of the Notice of Conversion to the office of the 
Corporation or the Transfer Agent for the Series E Preferred Stock as soon as 
practicable thereafter.  The Corporation shall not be obligated to issue 
certificates evidencing the shares of Common Stock issuable upon such 
conversion, unless either the Preferred Stock Certificates are delivered to 
the Corporation or its Transfer Agent as provided above, or the holder 
notifies the Corporation or its Transfer Agent that such certificates have 
been lost, stolen or destroyed (subject to the requirements of subparagraph 
(a) below).  In the case of a dispute as to the calculation of the Conversion 
Price, the Corporation shall promptly issue such number of shares of Common 
Stock that are not disputed in accordance with subparagraph (b) below.  The 
Corporation shall submit the disputed calculations to its outside accountant 
via facsimile within two (2) business days of receipt of the Notice of 
Conversion.  The accountant shall audit the calculations and notify the 
Corporation and the holder of the results no later than 48 hours from the 
time it receives the disputed calculations.  The accountant's calculation 
shall be deemed conclusive absent manifest error.

          (a)  LOST OR STOLEN CERTIFICATES.  Upon receipt by the Corporation 
of evidence of the loss, theft, destruction or mutilation of any Preferred 
Stock Certificates representing shares of Series E Preferred Stock, and (in 
the case of loss, theft or destruction) of indemnity reasonably satisfactory 
to the Corporation, and upon surrender and cancellation of the Preferred 
Stock Certificate(s), if mutilated, the Corporation shall execute and deliver 
new Preferred Stock Certificate(s) of like tenor and date.

          (b)  DELIVERY OF COMMON STOCK UPON CONVERSION.  Upon the surrender 
of certificates as described above together with a Notice of Conversion, the 
Corporation shall issue and, within two (2) business days after such 
surrender (or, in the case of lost, stolen or destroyed certificates, after 
provision of agreement and indemnification pursuant to subparagraph (a) 
above) (the "Delivery Period"), deliver (or cause its Transfer Agent to so 
issue and deliver) to or upon the order of the holder (i) that number of 
shares of Common Stock for the portion of the shares of Series E Preferred 
Stock converted as shall be determined in accordance herewith and (ii) a 
certificate representing the balance of the shares of Series E Preferred 
Stock not converted, if any. In addition to any other remedies available to 
the holder, including actual damages and/or equitable relief, the Corporation 
shall pay to a holder $1,000 per day in cash for each day beyond a two (2) 
day grace period following the Delivery Period that the Corporation fails to 
deliver Common Stock (a "Conversion Default") issuable upon surrender of 
shares of Series E Preferred Stock with a Notice of Conversion until such 
time as the Corporation has delivered all such Common Stock (the "Conversion 
Default Payments").  Such cash amount shall be paid to such holder by the 
fifth day of the month following the month in which it has accrued or, at the 
option of the holder (by written notice to the Corporation by the first day 
of the month following the month in which it has accrued), shall be 
convertible into Common Stock in accordance with the terms of this Article 
VI.  In lieu of delivering physical certificates representing the Common 
Stock issuable upon conversion, provided the Corporation's Transfer Agent is 
participating in the Depository Trust Company ("DTC") Fast Automated 
Securities Transfer ("FAST") program, upon request of the holder and its 
compliance with the provisions contained in Article VI. and in this Article 
VI.E, the Corporation shall use commercially reasonable efforts to cause its 
Transfer Agent to electronically transmit the Common Stock issuable upon 
conversion to the holder by crediting the account of holder's Prime Broker 
with DTC through its Deposit Withdrawal Agent Commission ("DWAC") system.  
The time periods for delivery and penalties described in the immediately 
preceding paragraph shall apply to the electronic transmittals described 
herein.

          (c)  NO FRACTIONAL SHARES. No fractional share shall be issued upon 
the conversion of any share or shares of  Series E Preferred Stock.  All 
shares of Common Stock (including fractions thereof) issuable upon conversion 
of Series E Preferred Stock as of a Conversion Date to a holder of Series E 
Preferred Stock shall be aggregated for purposes of determining whether the 
conversion would result in the issuance of any fractional share to such 
holder of Series E Preferred Stock.  If, after the aforementioned 
aggregation, the conversion would result in the issuance of a fraction of a 
share of Common Stock to such holder of Series E Preferred Stock, the 
Corporation shall, in lieu of issuing any fractional share, pay such holder 
otherwise entitled to such fraction a sum in cash equal to the Closing Price 
of the Common Stock on the Conversion Date, multiplied by such fraction.

                                      A-12
<PAGE>

          (d)  CONVERSION DATE.  The "Conversion Date" shall be the date 
specified in the Notice of Conversion, provided that the Notice of Conversion 
is submitted by facsimile (or by other means resulting in, or reasonably 
expected to result in, notice) to the Corporation or its Transfer Agent 
before Midnight, New York City time, on the Conversion Date.  The person or 
persons entitled to receive the shares of Common Stock issuable upon 
conversion shall be treated for all purposes as the record holder or holders 
of such securities as of the Conversion Date and all rights with respect to 
the shares of Series E Preferred Stock surrendered shall forthwith terminate 
except the right to receive the shares of Common Stock or other securities or 
property issuable on such conversion and except that the holders preferential 
rights as a holder of Series E Preferred Stock shall survive to the extent 
the Corporation fails to deliver such securities.

     E.   RESERVATION OF SHARES.  A number of shares of the authorized but 
unissued Common Stock sufficient to provide for the conversion of the Series 
E Preferred Stock outstanding at the then current Conversion Price shall at 
all times be reserved by the Corporation, free from preemptive rights, for 
such conversion or exercise.  As of the date of issuance of the Series E 
Preferred Stock, 6,550,000 authorized and unissued shares of Common Stock 
have been duly reserved for issuance upon conversion of the Series E 
Preferred Stock (the "Reserved Amount").  The Reserved Amount shall be 
increased from time to time in accordance with the Corporation's obligations 
pursuant to Section 4(h) of the Purchase Agreement.  In addition, if the 
Corporation shall issue any securities or make any change in its capital 
structure which would change the number of shares of Common Stock into which 
each share of the Series E Preferred Stock shall be convertible at the then 
current Conversion Price, the Corporation shall at the same time also make 
proper provision so that thereafter there shall be a sufficient number of 
shares of Common Stock authorized and reserved, free from preemptive rights, 
for conversion of the outstanding Series E Preferred Stock.

     If at any time a holder of shares of Series E Preferred Stock submits a 
Notice of Conversion, and the Corporation does not have sufficient authorized 
but unissued shares of Common Stock available to effect such conversion in 
accordance with the provisions of this Article VI (a "Conversion Default"), 
the Corporation shall issue to the holder (or holders, if more than one 
holder submits a Notice of Conversion in respect of the same Conversion Date, 
pro rata based on the ratio that the number of shares of Series E Preferred 
Stock then held by each such holder bears to the aggregate number of such 
shares held by such holders) all of the shares of Common Stock which are 
available to effect such conversion.  The number of shares of Series E 
Preferred Stock included in the Notice of Conversion which exceeds the amount 
which is then convertible into available shares of Common Stock (the "Excess 
Amount") shall, notwithstanding anything to the contrary contained herein, 
not be convertible into Common Stock in accordance with the terms hereof 
until (and at the holder's option at any time after) the date additional 
shares of Common Stock are authorized by the Corporation to permit such 
conversion, at which time the Conversion Price in respect thereof shall be 
the lesser of (i) the Conversion Price on the Conversion Default Date (as 
defined below) and (ii) the Conversion Price on the Conversion Date elected 
by the holder in respect thereof.  The Corporation shall use its best efforts 
to effect an increase in the authorized number of shares of Common Stock as 
soon as possible following a Conversion Default.  In addition, the 
Corporation shall pay to the holder payments ("Conversion Default Payments") 
for a Conversion Default in the amount of (a) (N/365), multiplied by (b) the 
sum of the Stated Value plus the Premium Amount per share of Series E 
Preferred Stock through the Authorization Date (as defined below), multiplied 
by (c) the Excess Amount on the day the holder submits a Notice of Conversion 
giving rise to a Conversion Default (the "Conversion Default Date"), 
multiplied by (d) .24, where (i) N = the number of days from the Conversion 
Default Date to the date (the "Authorization Date") that the Corporation 
authorizes a sufficient number of shares of Common Stock to effect conversion 
of the full number of shares of Series E Preferred Stock.  The Corporation 
shall send notice to the holder of the authorization of additional shares of 
Common Stock, the Authorization Date and the amount of holder's accrued 
Conversion Default Payments.  The accrued Conversion Default Payment for each 
calendar month shall be paid in cash or shall be convertible into Common 
Stock at the Conversion Price, at the holder's option, as follows:

          (a)  In the event the holder elects to take such payment in cash, 
cash payment shall be made to holder by the fifth day of the month following 
the month in which it has accrued; and

          (b)  In the event the holder elects to take such payment in Common
Stock, the holder may convert such payment amount into Common Stock at the
Conversion Price (as in effect at the time of Conversion) at 

                                      A-13
<PAGE>

any time after the fifth day of the month following the month in which it has 
accrued in accordance with the terms of this Article VI (so long as there is 
then a sufficient number of authorized shares).

     Nothing herein shall limit the holder's right to pursue actual damages 
for the Corporation's failure to maintain a sufficient number of authorized 
shares of Common Stock, and each holder shall have the right to pursue all 
remedies available at law or in equity (including a decree of specific 
performance and/or injunctive relief).

     F.   NOTICE OF CONVERSION PRICE ADJUSTMENTS.  Upon the occurrence of 
each adjustment or readjustment of the Conversion Price pursuant to this 
Article VI, the Corporation, at its expense, shall promptly compute such 
adjustment or readjustment in accordance with the terms hereof and prepare 
and furnish to each holder of Series E Preferred Stock a certificate setting 
forth such adjustment or readjustment and showing in detail the facts upon 
which such adjustment or readjustment is based.  The Corporation shall, upon 
the written request at any time of any holder of Series E Preferred Stock, 
furnish or cause to be furnished to such holder a like certificate setting 
forth (i) such adjustment or readjustment, (ii) the Conversion Price at the 
time in effect and (iii) the number of shares of Common Stock and the amount, 
if any, of other securities or property which at the time would be received 
upon conversion of a share of Series E Preferred Stock.

     G.   STATUS AS STOCKHOLDERS.  Upon submission of a Notice of Conversion 
by a holder of Series E Preferred Stock, (i) the shares covered thereby 
(other than the shares, if any, which cannot be issued because their issuance 
would exceed such holder's allocated portion of the Reserved Amount) shall be 
deemed converted into shares of Common Stock and (ii) the holder's rights as 
a holder of such converted shares of Series E Preferred Stock shall cease and 
terminate, excepting only the right to receive certificates for such shares 
of Common Stock and to any remedies provided herein or otherwise available at 
law or in equity to such holder because of a failure by the Corporation to 
comply with the terms of this Certificate of Designation.  Notwithstanding 
the foregoing, if a holder has not received certificates for all shares of 
Common Stock prior to the tenth (10th) business day after the expiration of 
the Delivery Period with respect to a conversion of shares of Series E 
Preferred Stock for any reason, then (unless the holder otherwise elects to 
retain its status as a holder of Common Stock by so notifying the 
Corporation) the holder shall regain the rights of a holder of such shares of 
Series E Preferred Stock with respect to such unconverted shares of Series E 
Preferred Stock and the Corporation shall, as soon as practicable, return 
such unconverted shares of Series E Preferred Stock to the holder or, if such 
shares of Series E Preferred Stock have not been surrendered, adjust its 
records to reflect that such shares of Series E Preferred Stock have not been 
converted.  In all cases, the holder shall retain all of its rights and 
remedies (including, without limitation, the right to receive Conversion 
Default Payments pursuant to Article IV.D to the extent required thereby for 
such Conversion Default and any subsequent Conversion Default).

                              VII.  AUTOMATIC CONVERSION

     So long as the Registration Statement is effective and there is not then 
a continuing Mandatory Redemption Event, each share of Series E Preferred 
Stock issued and outstanding on June 8, 2001 (the "Automatic Conversion 
Date"), automatically shall be converted into shares of Common Stock on such 
date at the then effective Conversion Price in accordance with, and subject 
to, the provisions of Article VI hereof (the "Automatic Conversion").  The 
Automatic Conversion Date shall be delayed by one (1) Trading Day each for 
each Trading Day occurring prior thereto and prior to the full conversion of 
the Series E Preferred Stock that (i) sales cannot be made pursuant to the 
Registration Statement (whether by reason of the Corporation's failure to 
properly supplement or amend the prospectus included therein in accordance 
with the terms of the Registration Rights Agreement or otherwise including 
any Allowed Delays (as defined in Section 3(f) of the Registration Rights 
Agreement) and any Permitted Offering Delays as defined in Section 3(g) of 
the Registration Rights Agreement)), (ii) any Mandatory Redemption Event (as 
defined in Article V.A) exists, without regard to whether any cure periods 
shall have run or (iii) pursuant to Article V.A with respect to a Mandatory 
Redemption Event described in Article V.A(ii).  The Automatic Conversion Date 
shall be the Conversion Date for purposes of determining the Conversion Price 
and the time within which certificates representing the Common Stock must be 
delivered to the holder.

                                      A-14
<PAGE>

                               VIII.  VOTING RIGHTS

     A.   GENERALLY.  Except as set forth herein, or as otherwise provided by 
the Delaware General Corporation Law ("DGCL"), the holders of the Series E 
Preferred Stock shall have no voting rights and their consent shall not be 
required (except to the extent they are entitled to vote with holders of 
Common Stock as set forth herein) for taking any corporate action.

     B.   NOTICE OF MEETINGS.  Notwithstanding the above, the Corporation 
shall provide each holder of Series E Preferred Stock with prior notification 
of any meeting of the stockholders (and copies of proxy materials and other 
information sent to stockholders at the time such materials are provided to 
the stockholders of the Corporation entitled to vote).  In the event of any 
taking by the Corporation of a record of its stockholders for the purpose of 
determining stockholders who are entitled to receive payment of any dividend 
or other distribution, any right to subscribe for, purchase or otherwise 
acquire (including by way of merger, consolidation or recapitalization) any 
share of any class or any other securities or property, or to receive any 
other right, or for the purpose of determining stockholders who are entitled 
to vote in connection with any proposed sale, lease or conveyance of all or 
substantially all of the assets of the Corporation, or any proposed 
liquidation, dissolution or winding up of the Corporation, the Corporation 
shall mail a notice to each holder, at least ten (10) days prior to the 
record date specified therein (or twenty (20) days prior to the consummation 
of the  transaction or event, whichever is earlier), of the date on which any 
such record is to be taken for the purpose of such dividend, distribution, 
right or other event, and a brief statement regarding the amount and 
character of such dividend, distribution, right or other event to the extent 
known at such time.

     C.   VOTE REQUIRED.  To the extent that under the DGCL the vote of the 
holders of the Series E Preferred Stock, voting separately as a class or 
series as applicable, is required to authorize a given action of the 
Corporation, the affirmative vote or consent of the holders of at least a 
majority of the shares of the Series E Preferred Stock represented at a duly 
held meeting at which a quorum is present or by written consent of a majority 
of the shares of Series E Preferred Stock (except as otherwise may be 
required under the DGCL) shall constitute the approval of such action by the 
class.  To the extent that under the DGCL holders of the Series E Preferred 
Stock are entitled to vote on a matter with holders of Common Stock, voting 
together as one class, each share of Series E Preferred Stock shall be 
entitled to a number of votes equal to the number of shares of Common Stock 
into which it is then convertible using the record date for the taking of 
such vote of stockholders as the date as of which the Conversion Price is 
calculated.  Holders of the Series E Preferred Stock shall be entitled to 
notice of all shareholder meetings or written consents (and copies of proxy 
materials and other information sent to stockholders at the time such 
materials are provided to the stockholders of the Corporation entitled to 
vote) with respect to which they would be entitled to vote, which notice 
would be provided pursuant to the Corporation's bylaws and the DGCL.

                           IX.  PROTECTIVE PROVISIONS

     So long as shares of Series E Preferred Stock are outstanding, the 
Corporation shall not, without first obtaining the approval (by vote or 
written consent, as provided by the DGCL) of the holders of at least a 
majority of the then outstanding shares of Series E Preferred Stock:

          (a)  alter or change the rights, preferences or privileges of the 
Series E Preferred Stock or any Senior Securities so as to affect adversely 
the rights, preferences and privileges of the Series E Preferred Stock; 
PROVIDED, HOWEVER, that any increase in the authorized preferred stock of the 
Corporation (other than an increase in the authorized number of shares of 
Series E Preferred Stock) or the creation and issuance of any Junior 
Securities or any PARI PASSU Securities as permitted pursuant to the terms 
hereof shall not be deemed to affect adversely the right, preferences and 
privileges of the Series E Preferred Stock.

          (b)  create any new class or series of Senior Securities;

          (c)  create any new class or series of PARI PASSU Securities, 
unless the average Closing bid Price for the ten (10) Trading Days ending one 
(1) Trading Day prior to the date on which the Board of Directors 

                                      A-15
<PAGE>

approve the issuance of such class or series of capital stock is above $4.00, 
in which case such consent will not be required;

          (d)  increase the authorized number of shares of Series E Preferred 
Stock; or

          (e)  do any act or thing not authorized or contemplated by this 
Certificate of Designation which would result in taxation of the holders of 
shares of the Series E Preferred Stock under Section 305 of the Internal 
Revenue Code of 1986, as amended (or any comparable provision of the Internal 
Revenue Code as hereafter from time to time amended).

     In the event holders of at least a majority of the then outstanding 
shares of Series E Preferred Stock agree to allow the Corporation to alter or 
change the rights, preferences or privileges of the shares of Series E 
Preferred Stock, pursuant to subsection (a) above, so as to affect the Series 
E Preferred Stock, then the Corporation will deliver notice of such approved 
change to the holders of the Series E Preferred Stock that did not agree to 
such alteration or change (the "Dissenting Holders") and Dissenting Holders 
shall have the right for a period of thirty (30) days to convert pursuant to 
the terms of this Certificate of Designation as they exist prior to such 
alteration or change or continue to hold their shares of Series E Preferred 
Stock.

                             X.  PRO RATA ALLOCATIONS

     The Maximum Share Amount and the Reserved Amount (including any 
increases thereto) shall be allocated by the Corporation pro rata among the 
holders of Series E Preferred Stock based on the number of shares of Series E 
Preferred Stock then held by each holder relative to the total aggregate 
number of shares of Series E Preferred Stock then outstanding.

     IN WITNESS WHEREOF, this Certificate of Designation is executed on 
behalf of the Corporation this 8th day of June, 1998.

                                      COCENSYS, INC.



                                      By: /s/ F. RICHARD NICHOL
                                          -------------------------
                                          F. Richard Nichol, Ph.D.
                                          President and Chief Executive Officer

                                      A-16
<PAGE>

                                                                       EXHIBIT A
                                 NOTICE OF CONVERSION

                      (To be Executed by the Registered Holder
                 in order to Convert the Series E Preferred Stock)

     The undersigned hereby irrevocably elects to convert ____ shares of 
Series E Preferred Stock, represented by stock certificate No(s). __________ 
(the "Preferred Stock Certificates") into shares of common stock ("Common 
Stock") of CoCensys, Inc. (the "Corporation") according to the conditions of 
the Certificate of Designation of Series E Preferred Stock, as of the date 
written below.  If securities are to be issued in the name of a person other 
than the undersigned, the undersigned will pay all transfer taxes payable 
with respect thereto and is delivering herewith such certificates.  No fee 
will be charged to the Holder for any conversion, except for transfer taxes, 
if any.  A copy of each Preferred Stock Certificate is attached hereto (or 
evidence of loss, theft or destruction thereof).

     The undersigned represents and warrants that all offers and sales by the 
undersigned of the securities issuable to the undersigned upon conversion of 
the Series E Preferred Stock shall be made pursuant to registration of the 
securities under the Securities Act of 1933, as amended (the "Act"), or 
pursuant to an exemption from registration under the Act.

     Date of Conversion:___________________________

     Three Lowest Trade Prices:_____________________

     Applicable Conversion Price:____________________

     Number of Shares of
     Common Stock to be Issued:_____________________

     Signature:____________________________________

     Name:_______________________________________

     Address:______________________________________

*The Corporation is not required to issue shares of Common Stock until the 
original Series E Preferred Stock Certificate(s) (or evidence of loss, theft 
or destruction thereof) to be converted are received by the Corporation or 
its Transfer Agent.  The Corporation shall issue and deliver shares of Common 
Stock to an overnight courier not later than two (2) business days following 
receipt of the original Preferred Stock Certificate(s) to be converted, and 
shall make payments pursuant  to the Certificate of Designation for the 
number of business days such issuance and delivery is late.

                                      A-17
<PAGE>

                                    APPENDIX B

                           CERTIFICATE OF AMENDMENT OF
                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION,
                          AS AMENDED, OF COCENSYS, INC.


     CoCensys, Inc., (the "Corporation"), a corporation organized and 
existing under and by virtue of the General Corporation Law of the State of 
Delaware, does hereby certify:

     FIRST:   The name of the Corporation is CoCensys, Inc.

     SECOND:  The date on which the Amended and Restated Certificate of 
Incorporation was filed with the Secretary of State of the State of Delaware 
(the "Delaware Secretary of State) is February 5, 1993.  A Certificate of 
Retirement of Series A, Series B and Series C Preferred stock was filed with 
the Delaware Secretary of State on February 5, 1993.  A Certificate of 
Designation of Series A Junior Participating Preferred Stock was filed with 
the Delaware Secretary of State on May 15, 1995.  A Certificate of Powers, 
Designation, Preferences, Rights and Limitations of Series B Convertible 
Preferred Stock was filed with the Delaware Secretary of State on May 17, 
1996.  A Certificate of Amendment of Amended and Restated Certificate of 
Incorporation of CoCensys, Inc. was filed with the Delaware Secretary of 
State on June 19, 1996.  A Certificate of Powers, Designation, Preferences, 
Rights and Limitations of Series C Convertible Preferred Stock was filed with 
the Delaware Secretary of State on May 12, 1997. A Certificate of Powers, 
Designation, Preferences, Rights and Limitations of Series D Convertible 
Preferred Stock was filed with the Delaware Secretary of State on October 14, 
1997.  A Certificate of Powers, Designation, Preferences, Rights and 
Limitations of Series E Convertible Preferred Stock was filed with the 
Delaware Secretary of State on June 8, 1998.

         THIRD:  The Board of Directors of the Corporation, acting in 
accordance with the provision of Sections 141 and 242 of the General 
Corporation Law of the State of Delaware, adopted resolutions at a meeting 
held on September 16, 1998 to amend the first paragraph of Article IV of the 
Amended and Restated Certificate of Incorporation, as amended, of the 
Corporation to read in its entirety as follows:

                                        "IV.

     A.   This Corporation is authorized to issue two classes of stock to be 
designated, respectively, "Common Stock" and "Preferred Stock."  The total 
numbers of shares which the Corporation is authorized to issue is eighty 
million (80,000,000) shares.  Seventy-five million (75,000,000) shares shall 
be Common Stock, each having a par value of one-tenth of one cent ($0.001).  
Five million (5,000,000) shares shall be Preferred Stock, each having a par 
value of one-tenth of one cent ($0.001).  Effective at the time of filing 
with the Secretary of State of the State of Delaware of this Certificate of 
Amendment of Amended and Restated Certificate of Incorporation, as amended 
(the "Effective Time"), each _____ (__) shares of the Corporation's Common 
Stock issued and outstanding shall, automatically and without any action on 
the part of the respective holders thereof, be converted into one (1) share 
of Common Stock of the Corporation. No fractional shares shall be issued and, 
in lieu thereof, any holder of less than one share of Common Stock shall be 
entitled to receive cash for such holder's fractional share based upon the 
closing sales price of the Corporation's Common Stock as reported on the 
Nasdaq National Market as of the date of the Effective Time."

         FOURTH:  Pursuant to a resolution of the Board of Directors, this 
Certificate of Amendment of Amended and Restated Certificate of 
Incorporation, as amended, was submitted to the stockholders of the 
Corporation and was duly approved by the required vote of stockholders of the 
Corporation in accordance with Sections 228 and 242 of the Delaware General 
Corporation Law.  The total number of outstanding shares entitled to vote or 
consent to this Amendment was 27,280,949 shares of Common Stock. A majority 
of the outstanding shares of Common Stock voted in favor of this Certificate 
of Amendment of Amended and Restated Certificate of Incorporation, as amended.

                                      B-1
<PAGE>

         IN WITNESS WHEREOF, CoCensys, Inc. has caused this Certificate of 
Amendment to be signed by its President and attested to by its Secretary this 
___ day of ________, 1999.

                              COCENSYS, INC.



                              ---------------------------------------------
                              F. Richard Nichol, Ph.D.
                              President, Chief Executive Officer and Chairman of
                              the Board


ATTEST:


- --------------------------------------
Robert R. Holmen
Vice President, General Counsel and Secretary


                                      B-2
<PAGE>


                                   COCENSYS, INC.
                     PROXY SOLICITED BY THE BOARD OF DIRECTORS
                      FOR THE SPECIAL MEETING OF STOCKHOLDERS

                            TO BE HELD JANUARY 27, 1999


The undersigned hereby appoints LOWELL E. SEARS and F. RICHARD NICHOL, PH.D., 
and each of them, as attorneys and proxies of the undersigned, with full 
power of substitution, to vote all of the shares of stock of CoCensys, Inc. 
which the undersigned may be entitled to vote at the Special Meeting of 
Stockholders of CoCensys, Inc. to be held at the offices of CoCensys, 201 
Technology Drive, Irvine, California on Wednesday, January 27, 1999, at 2:00 
p.m. local time, and at any and all continuations and adjournments thereof, 
with all powers that the undersigned would possess if personally present, 
upon and in respect of the following matters and in accordance with the 
following instructions, with discretionary authority as to any and all other 
matters that may properly come before the meeting.

UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR 
APPROVAL OF PROPOSALS 1 AND 2 AS MORE SPECIFICALLY DESCRIBED IN THE PROXY 
STATEMENT.  IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED 
IN ACCORDANCE THEREWITH.  THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS A 
VOTE FOR APPROVAL OF PROPOSALS 1 AND 2.
                                       
                         (CONTINUED ON OTHER SIDE)

- --------------------------------------------------------------------------------

/X/ Please mark your vote as in this example.


PROPOSAL 1:  To approve the issuance by the Company from time to time of 
             shares of its Common Stock on conversion of shares of the 
             Company's Series E Convertible Preferred Stock and exercise of 
             warrants issued in connection with such Series E Convertible 
             Preferred Stock.

             / / FOR        / / AGAINST    / / ABSTAIN


PROPOSAL 2:  To approve a proposal to provide the Board of Directors the 
             authority to amend the Company's Amended and Restated 
             Certificate of Incorporation, as amended, to effect, at any time 
             prior to the 1999 Annual Meeting of Stockholders, a reverse 
             stock split, whereby the Company would issue one new share of 
             Common Stock in exchange for between four and ten shares of 
             outstanding Common Stock.

             / / FOR        / / AGAINST    / / ABSTAIN


PLEASE VOTE, DATE AND PROMPTLY RETURN THIS PROXY IN THE ENCLOSED RETURN 
ENVELOPE, WHICH IS POSTAGE PREPAID IF MAILED IN THE UNITED STATES.  THANK YOU.

Signature(s):                                       Date:
             --------------------------------------       --------------------

Note:  Please sign exactly as your name appears hereon.  If the stock is 
       registered in the names of two or more persons, each should sign.  
       Executors, administrators, trustees, guardians and attorneys-in-fact 
       should add their titles.  If signer is a corporation, please give full 
       corporate name and have a duly authorized officer sign, stating title. 
       If signer is a partnership, please sign in partnership name by 
       authorized person.



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission