COCENSYS INC
8-K, 1999-05-19
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                          SECURITIES AND EXCHANGE COMMISSION
                                WASHINGTON, DC  20549



                                   ---------------



                                       FORM 8-K



                                    CURRENT REPORT
                        PURSUANT TO SECTION 13 OR 15(d) OF THE
                           SECURITIES EXCHANGE ACT OF 1934


          Date of report (Date of earliest event reported):  MAY 18, 1999
                                                            -------------



                                    COCENSYS, INC.
                                    --------------
                  (Exact Name of Registrant as Specified in Charter)



DELAWARE                            0-20954                           33-0538836
- --------                            --------                          ----------
(State or Other                   (Commission                      (IRS Employer
Jurisdiction of                   File Number)               Identification No.)
Incorporation)



201 TECHNOLOGY DRIVE, IRVINE, CALIFORNIA                                   92618
- ----------------------------------------                                   -----
(Address of Principal Executive Office)                               (Zip Code)



         Registrant's telephone number, including area code: (949) 753-6100
                                                             --------------


                                     Page 1 of 17

<PAGE>

ITEM 2.  ACQUISITION OR DISPOSITION OF ASSETS.

On May 18, 1999, CoCensys sold to certain entities affiliated with Domain
Associates, L.L.C., all of CoCensys' stockholdings in Cytovia, Inc., for an
aggregate purchase price of $3,325,500.  James C. Blair, Ph.D., a director of
the Company, is a managing member of Domain Associates, L.L.C.; in addition,
certain of the purchasing entities are current stockholders of CoCensys.

Cytovia was formed in 1998 as a technology spin-off from CoCensys to
commercialize apoptosis inhibitor and screening cell technology.  Among other
rights, CoCensys had retained an equity stake in Cytovia as part of the
spin-off.  CoCensys determined to sell its stockholdings in Cytovia to raise
funds to repurchase shares of CoCensys' Series E Convertible Preferred Stock. 
Accordingly, CoCensys entered into an agreement dated May 6, 1999, to sell its
stockholdings in Cytovia, subject to certain closing conditions.  The purchase
price for the Cytovia shares was established by negotiations between CoCensys
and the purchasers, and approved by unanimous vote of the disinterested CoCensys
directors.

CoCensys originally issued and sold $8,000,000 (8,000 shares) of its Series E
Preferred to three investors in a private placement transaction on June 8, 1998.
By agreements dated April 30, 1999, CoCensys agreed to repurchase up to
$3,180,000 (3,180 shares) of its Series E Convertible Preferred Stock from the
three holders of the Series E Preferred, using the proceeds from its sale of the
Cytovia shares.  The repurchase price for each share of Series E Preferred
equaled the face value ($1,000) plus accrued dividends at 7.5% per annum, plus a
5% premium. 

As part of the repurchase agreements with the holders of the Series E Preferred,
the holders agreed not to convert additional shares of Series E Preferred prior
to July 29, 1999, unless any of the following conditions are applicable:  (i)
CoCensys' common stock is trading above $1.00 per share or at least 120% of the
then-applicable conversion price for the Series E Preferred; (ii) CoCensys'
common stock no longer is trading on the Nasdaq National Market or Nasdaq
SmallCap Market; (iii) CoCensys has announced that it is being sold pursuant to
a merger or sale of all or substantially all of its assets; (iv) after a
material adverse change in CoCensys' business; or (v) if the SEC does not
declare effective by June 14, 1999, CoCensys' Registration Statement on Form S-3
filed with the SEC to register additional shares of common stock issuable on
conversion of the Series E Preferred.

Based on the anticipated receipt of proceeds from sale of CoCensys' Cytovia
shares, CoCensys repurchased 1,154 Series E Preferred shares on April 30, 1999
for $1,295,000, and repurchased an additional 437 shares on May 6, 1999 for
$491,000.  On May 18, 1999, upon consummation of the sale of its Cytovia shares,
CoCensys repurchased the additional 1,589 shares of its Series E Preferred for
$1,790,000.

Following completion of the repurchase of the 3,180 shares of Series E
Preferred, and taking into account conversions of the Series E Preferred through
May 17, 1999, $1,797,000 (including accrued dividends) of Series E Preferred
remains outstanding.  As of that date, CoCensys had 4,633,000 shares of common
stock issued and outstanding. 


                                     Page 2 of 17

<PAGE>

ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

     (c)  EXHIBITS.  The following exhibits are attached to this Current Report
on Form 8-K:

<TABLE>
<CAPTION>

                                                                      Sequential
     Exhibit   Description                                            Page Start
     -------   -----------                                            ----------
     <S>       <C>                                                    <C>
     99.1      Stock Purchase Agreement dated May 6, 1999, among
               CoCensys and the purchasers set forth therein.                 4
     99.2      Agreement dated April 30, 1999, between CoCensys and
               RGC International Investors, LDC                              10
     99.3      Agreement dated April 30, 1999, among CoCensys,
               Heracles Fund and Themis Parnters L.P.                        12
     99.4      Press Release entitled "CoCensys, Inc. Agrees to Sell Its
               Holdings in Cytovia, Inc." dated May 11, 1999                 14
     99.5      Press Release entitled "CoCensys, Inc. Completes Sale
               of Holdings in Cytovia, Inc. and Partial Repurchase
               of its Series E Preferred Stock" dated May 18, 1999           17



</TABLE>

                                      SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                   COCENSYS, INC.
                                   --------------
                                   (Registrant)


Date:  May 18, 1999                By:  /s/ Robert R. Holmen               
                                        ----------------------------------------
                                        Vice President and General Counsel


                                     Page 3 of 17


<PAGE>

                          STOCK PURCHASE AGREEMENT                EXHIBIT 99.1
                                          

       THIS STOCK PURCHASE AGREEMENT (the "Agreement") is made as of May 6, 1999
by and between COCENSYS, INC., a Delaware corporation (the "Company") and the
purchasers set forth on the signature pages of this Agreement (collectively, the
"Purchaser").

       1.     PURCHASE AND SALE

              1.1    PURCHASE AND SALE.  Subject to the terms and conditions set
forth herein, and in reliance on the representations, warranties and agreements
set forth in Sections 2 and 3 hereof, the Company hereby agrees to sell to
Purchaser, and Purchaser hereby agrees to purchase from the Company, Four
Hundred Fifty Thousand (450,000) shares (the "Shares") of Series A-1 Junior
Preferred Stock of Cytovia, Inc. ("Cytovia"), for $7.39 per share, or an
aggregate total of $3,325,500 (the "Purchase Price").

              1.2    CLOSING.  The consummation of the purchase and sale of the
Shares (the "Closing") shall take place on the second business day following
satisfaction of all conditions to close set forth below, or such other date as
the Company and Purchaser shall agree (the "Closing Date").  At the Closing, the
Company will deliver to Purchaser a certificate or certificates for the Shares,
with the endorsement(s) on the reverse thereof, or an assignment separate from
certificate, duly completed and executed, and Purchaser shall pay the Purchaser
Price by wire transfer pursuant to the Company's instructions.

       2.     REPRESENTATIONS AND WARRANTIES OF THE COMPANY

              The Company hereby represents and warrants to Purchaser as
follows:

              2.1    INTEREST IN SHARES.  The Company is the record owner of the
Shares and, subject to satisfaction of the conditions set forth in Section 4.1
hereof, has the power to transfer its right, title and interest in the Shares to
Purchaser.

              2.2    AUTHORIZATION.  All corporate action on the part of the
Company, its officers, directors and stockholders necessary for the
authorization, execution and delivery of this Agreement, the performance of all
the Company's obligations hereunder and thereunder, and for the sale and
delivery of the Shares has been taken or will be taken prior to the Closing. 
This Agreement, when executed and delivered, shall constitute a valid and
legally binding obligation of the Company in accordance with its terms, subject
to laws of general application relating to bankruptcy, insolvency and the relief
of debtors.

              2.3    NO SOLICITATION.  The Company knows the Purchaser
personally.  The Company has made no general solicitation in connection with the
Shares and has not offered the Shares to anyone other than Purchaser.


                                     Page 4 of 17

<PAGE>

       3.     REPRESENTATIONS, WARRANTIES AND COVENANTS OF PURCHASER

              Purchaser hereby represents and warrants to the Company as
follows:

              3.1    LEGAL POWER.  Purchaser has the requisite legal power to
enter into this Agreement, to purchase the Shares hereunder, and to carry out
and perform its obligations under the terms of this Agreement.

              3.2    AUTHORIZATION.  This Agreement has been duly authorized,
executed and delivered by Purchaser, and, upon due execution and delivery by the
Company, this Agreement will be a valid and binding agreement of it.

              3.3    INVESTMENT REPRESENTATIONS.

                     (a)    Purchaser is an "accredited investor," as that term
is defined in Regulation D of the Securities Act of 1933, as amended (the
"Securities Act").

                     (b)    Purchaser is acquiring the Shares solely for its own
account for investment and not with a view to or for sale or distribution of the
Shares or any part thereof.  The entire legal and beneficial interests of the
Shares Purchaser is acquiring is being acquired for, and will be held for,
Purchaser's account only.

                     (c)    Purchaser understands that the Shares have not been
registered under the Securities Act of 1933, as amended (the "Securities Act"),
on the basis that no distribution or public offering of the Shares is to be
effected.  Purchaser realizes that the basis for the exemption may not be
present if, notwithstanding the undersigned's representations, the undersigned
has in mind merely acquiring the Shares for a fixed or determinable period in
the future, or for a market rise, or for sale if the market does not rise. 
Purchaser has no such intention.

                     (d)    Purchaser recognizes that the Shares must be held
indefinitely unless they are subsequently registered under the Securities Act or
an exemption from such registration is available.  Purchaser recognizes that
Cytovia has no obligation to register the Shares or to comply with any exemption
from such registration.

                     (e)    Purchaser is aware that the Shares may not be sold
pursuant to Rule 144 adopted under the Securities Act ("Rule 144") unless
certain conditions are met and until Purchaser has held the Shares for at least
one year.  Among the conditions for use of the rule is the availability of
current information to the public about Cytovia.  The undersigned understands
that Cytovia has not made such information available and has no present plans to
do so.
       
                     (f)    Purchaser further agrees not to make any disposition
of all or any part of the Shares in any event unless and until:


                                     Page 5 of 17

<PAGE>

                            (i)    the Shares are transferred pursuant to Rule
144, and Cytovia shall have received from documentation acceptable to it that a
sale of the Shares has occurred in accordance with all of the provisions of Rule
144; or

                            (ii)   Cytovia shall have received a letter secured
by Purchaser from the Securities and Exchange Commission stating that no action
will be recommended to the Commission with respect to the proposed disposition;
or

                            (iii)  there is then in effect a registration
statement under the Securities Act covering such proposed disposition and such
disposition is made in accordance with said registration statement; or

                            (iv)   (x) Purchaser shall have notified Cytovia of
the proposed disposition and shall have furnished Cytovia with a detailed
statement of the circumstances surrounding the proposed disposition, (y)
Purchaser shall have furnished Cytovia with an opinion of counsel for Purchaser
to the effect that such disposition will not require registration of such Shares
under the Securities Act, and (z) such opinion of counsel for Purchaser shall
have been concurred in by Cytovia's counsel.

                     (g)    Purchaser agrees to be bound by any and all
restrictions and obligations with respect to the Shares as may be set forth in
any stock purchase, stock registration, co-sale, investors' rights agreement or
any bylaw or other agreement or document relating to the Shares.
       
                     (h)    Purchaser understands and agrees that all
certificates evidencing the Shares may bear the following legend:
       
              "THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE
              SECURITIES ACT OF 1933, AS AMENDED.  THEY MAY NOT BE
              SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN
              THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT
              AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF
              COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH
              REGISTRATION IS NOT REQUIRED."
              
       4.     CONDITIONS TO CLOSING

              4.1    CONDITIONS TO OBLIGATIONS OF PURCHASER.  Purchaser's
obligation to purchase the Shares is subject to the fulfillment, at or prior to
the Closing, of all of the following conditions, any of which may be waived by
Purchaser:

                     (a)    REPRESENTATIONS AND WARRANTIES TRUE; PERFORMANCE OF
OBLIGATIONS.  The representations and warranties made by the Company in Section
2 hereof shall be true and correct in all material respects on the Closing Date
with the same force and effect as if they had been made on and as of said date;
and the Company shall have performed all obligations and conditions herein
required to be performed by it on or prior to the Closing.


                                     Page 6 of 17

<PAGE>

                     (b)    QUALIFICATIONS, LEGAL INVESTMENT.  All
authorizations, approvals, or permits, if any, of any governmental authority or
regulatory body of the United States or of any state that are required in
connection with the lawful sale and issuance of the Shares pursuant to this
Agreement shall have been duly obtained and shall be effective on and as of the
Closing.  No stop order or other order in joining the sale of the Shares shall
have been issued and no proceedings for such purpose shall be pending or, to the
knowledge of the Company, threatened by the SEC or any commissioner of
corporations or similar officer of any other state having jurisdiction over this
transaction.  At the time of the Closing, the sale of the Shares shall be
legally permitted by all laws and regulations to which Purchaser and the Company
are subject.

                     (c)    WAIVER OF RIGHT OF FIRST REFUSAL.  Cytovia shall
have waived in writing the right of first refusal set forth in Article XIV,
Section 46, of its bylaws, or such right shall be deemed not to apply by virtue
of subsection (f)(3) thereof.

              4.2    CONDITIONS TO OBLIGATIONS OF THE COMPANY.  The Company's
obligation to sell the Shares at the Closing is subject to the fulfillment to
the Company's satisfaction, at or prior to the Closing, of the following
conditions, any of which may be waived by the Company:
       
                     (a)    REPRESENTATIONS AND WARRANTIES TRUE.  The
representations and warranties made by Purchaser in Section 3 hereof shall be
true and correct at the Closing Date, with the same force and effect as if they
had been made on and as of said date.
       
                     (b)    PERFORMANCE OF OBLIGATIONS.  Purchaser shall have
performed and complied with all agreements and conditions herein required to be
performed or complied with by it on or before the Closing.
       
                     (c)    QUALIFICATIONS, LEGAL INVESTMENT.  All
authorizations, approvals, or permits, if any, of any governmental authority or
regulatory body of the United States or of any state that are required in
connection with the lawful sale and issuance of the Shares pursuant to this
Agreement shall have been duly obtained and shall be effective on and as of the
Closing.  No stop order or other order enjoining the sale of the Shares shall
have been issued and no proceedings for such purpose shall be pending or, to the
knowledge of the Company, threatened by the SEC or any commissioner of
corporations or similar officer of any state having jurisdiction over this
transaction.  At the time of the Closing, the sale and issuance of the Shares
shall be legally permitted by all laws and regulations to which Purchaser and
the Company are subject.

                     (d)    WAIVER OF CO-SALE RIGHTS.  The rights of co-sale set
forth in Section 5.1 of that certain Investor Rights Agreement, dated March 27,
1998, by and among Cytovia and the Founders and Investors named therein, shall
have been waived in writing by each of the Investors.


                                     Page 7 of 17

<PAGE>

       5.     GOVERNING LAW.  This Agreement shall be governed by and construed
under the laws of the State of Delaware.
       
       6.     FURTHER EXECUTION.  The parties agree to execute such further
instruments and to take such further action as reasonably may be necessary to
carry out the intent of this Agreement.
       
       7.     NOTICES.  Any notice required or permitted hereunder shall be
given in writing and shall be deemed effectively given upon personal delivery or
three (3) days following mailing by registered or certified mail, postage and
fees prepaid, addressed to the parties at the address set forth in the signature
block below.

       8.     SUCCESSORS AND ASSIGNS.  This Agreement shall bind and inure to
the benefit of the successors and assigns of Company and Purchaser, to the
extent permitted under rules, regulations and agreements governing transfer of
the Shares.

       9.     ENTIRE AGREEMENT; AMENDMENT.  This Agreement constitutes the
entire agreement between the parties with respect to the sale to Purchaser or
any entity affiliated with Purchaser of the Shares, or any other shares of
Cytovia stock now or heretofore held by the Company, and supersedes and merges
all prior agreements or understandings, whether written or oral.  This Agreement
may not be amended, modified or revoked, in whole or in part, except by an
agreement in writing signed by each of the parties hereto.

       10.    COUNTERPARTS.  This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which
together shall constitute one instrument.


                                     Page 8 of 17

<PAGE>

This Agreement is hereby executed as of the date above first written.

COCENSYS, INC.                                   

By:  /s/                                     
     --------------------------------------       Address for notices:
     F. Richard Nichol, Ph.D.                     CoCensys, Inc.
     Chairman of the Board, President & CEO       201 Technology Drive
                                                  Irvine, CA 92618

PURCHASER

DOMAIN PARTNERS III, L.P.                         No. of Shares:  113,500
                                                  Dollar Amount:  $838,765.00
By:  One Palmer Square Associates III, L.P., 
     Its General Partner                          Address for notices:
                                                  C/o Domain Associates, L.L.C.
     By:  /s/                                     One Palmer Square
          ---------------------------------       Princeton, NJ 08542
          Kathleen K. Schoemaker                  
          General Partner

DP III ASSOCIATES, L.P.                           No. of Shares:  8,990
                                                  Dollar Amount:  $66,436.10
By:  One Palmer Square Associates III, L.P., 
     Its General Partner                          Address for notices:
                                                  C/o Domain Associates, L.L.C.
     By:  /s/                                     One Palmer Square
          ---------------------------------       Princeton, NJ 08542
          Kathleen K. Schoemaker             
          General Partner

DOMAIN PARTNERS IV, L.P.                          No. of Shares:  324,790
                                                  Dollar Amount:  $2,400,198.10
By:  One Palmer Square Associates IV, L.L.C.,     
     Its General Partner                          Address for notices:
                                                  C/o Domain Associates, L.L.C.
     By:  /s/                                     One Palmer Square
          ---------------------------------       Princeton, NJ 08542
          Kathleen K. Schoemaker             
          Managing Member

DP IV ASSOCIATES, L.P.                            No. of Shares:  2,720
                                                  Dollar Amount:  $20,100.80
By:  One Palmer Square Associates IV, L.L.C.,     
     Its General Partner                          Address for notices:
                                                  C/o Domain Associates, L.L.C.
     By:  /s/                                     One Palmer Square
          ---------------------------------       Princeton, NJ 08542
          Kathleen K. Schoemaker             
          Managing Member


                                     Page 9 of 17

<PAGE>

                                  AGREEMENT                        EXIHBIT 99.2
                                          
                                          
The undersigned parties hereby agree as follows:

1)   RGC International Investors, LDC, the holder of 3,655 outstanding shares
     (the "Shares") of Series E Convertible Preferred Stock of CoCensys, Inc.
     (the "Company") hereby agrees to sell to the Company the number of shares
     set forth below for a price equal to 105% of the sum of the par value
     thereof plus all accrued dividends thereon through the redemption date:

        RGC International Investors, LDC - 2,308

2)   50% of the Shares to be sold (the "First Tranche") shall be acquired by the
     Company on April 30, 1999 and the remaining 50% of the Shares to be sold
     (the "Second Tranche") shall be acquired not later than May 20, 1999;
     provided however, that the Second Tranche shall be cut back by the dollar
     value of co-sale rights exercised in connection with the sale of the
     Company's holdings in Cytovia, Inc.

3)   On the closing date for each tranche the Company shall wire transfer to the
     account of the selling holder the amount to be paid for the Shares being
     sold, and the selling holder shall deliver the certificates representing
     such Shares (with any excess Shares to be reissued by new certificate).

4)   The Company shall continue to use its best efforts to remain listed on
     NASDAQ and to gain effectiveness of a Registration Statement covering all
     of the common stock issuable upon conversion of the outstanding Shares and
     warrants issued in connection therewith, to the extent not currently
     registered.

5)   Subject to the exception set forth in the immediately following sentence,
     from the closing of the First Tranche until 90 days thereafter, the holders
     will not effect any conversions of the outstanding Shares.  The preceding
     restrictions will be exclusive of conversions that occur (A) on any day the
     Stock trades at a price greater than or equal to (1) 120% of the then
     applicable Market Price or (2) $1.00; (B) after a public announcement by
     the Issuer that it is being sold pursuant to a merger or sale of all or
     substantially all of its assets, etc.; (C) after a material adverse change
     in the Issuer's business; (D) after a NASDAQ delisting; or (E) after 45
     days from the closing of the First Tranche, if the Registration Statement
     referred to above is not declared effective.


                                    Page 10 of 17

<PAGE>

IN WITNESS WHEREOF, the undersigned have caused this Agreement to be duly
executed on the 30th day of April, 1999.


COCENSYS, INC.


By:       /s/                      
   ----------------------------------------
     F. Richard Nichol, Ph.D.
     President and Chief Executive Officer


RGC INTERNATIONAL INVESTORS, LDC
By:  Rose Glen Capital Management, L.P., Investment Manager
     By:  RGC General Partner Corp., as General Partner

By:       /s/                      
   ----------------------------------------
     Gary S. Kaminsky
     Managing Director


                                    Page 11 of 17


<PAGE>

                                  AGREEMENT                        EXIHBIT 99.3
                                          
                                          
The undersigned parties hereby agree as follows:

1)   Themis Partners L.P. and Heracles Fund, holders of the outstanding shares
     (the "Shares") of Series E Convertible Preferred Stock of CoCensys, Inc.
     (the "Company"), hereby agree to sell to the Company the number of shares
     set forth below for a price equal to 105% of the sum of the par value
     thereof plus all accrued dividends thereon through the redemption date:

        Themis Partners L.P. - 349
        Heracles Fund - 523

2)   50% of the Shares to be sold (the "First Tranche) shall be acquired by the
     Company on May 6, 1999 and the remaining 50% of the Shares to be sold (the
     "Second Tranche")shall be acquired not later than May 20, 1999; provided
     however, that the Second Tranche shall be cut back by the dollar value of
     co-sale rights exercised in connection with the sale of the Company's
     holdings in Cytovia, Inc.

3)   On the closing date for each tranche the Company shall wire transfer to the
     account of the selling holder the amount to be paid for the Shares being
     sold, with corresponding debits to the Company's ledger of Shares held by
     each of Themis Partners L.P. and Heracles Fund.

4)   The Company shall continue to use its best efforts to remain listed on
     NASDAQ and to gain effectiveness of a Registration Statement covering all
     of the common stock issuable upon conversion of the outstanding Shares and
     warrants issued in connection therewith, to the extent not currently
     registered.  Penalties related to listing and effectiveness of the
     Registration Statement remain in full force and effect in accordance with
     the "Series E Documents" (as defined below).

5)   Subject to the exception set forth in the immediately following sentence,
     from the closing of the First Tranche until 84 calendar days thereafter,
     the holders will not effect any conversions of the outstanding Shares.  The
     preceding restrictions will be exclusive of conversions that occur (A) on
     any day the Stock trades at a price greater than or equal to (1) 120% of
     the then applicable Market Price (as defined in the Certificate of Powers,
     Designation, Preferences, Rights and Limitations of Series E Convertible
     Preferred Stock dated June 8, 1998 (the "Series E Certificate") inclusive
     of any accrued penalties) or (2) $1.00; (B) after a public announcement by
     the Issuer that it is being sold pursuant to a merger or sale of all or
     substantially all of its assets, etc.; (C) after a material adverse change
     in the Issuer's business; (D) after a NASDAQ delisting; or (E) after 39
     calendar days from the closing of the First Tranche, if the Registration
     Statement referred to above is not declared effective.


                                    Page 12 of 17

<PAGE>

6)   Except as expressly set forth in Paragraph 5 of this Agreement, the parties
     agree that the Securities Purchase Agreement dated June 8, 1998, the Series
     E Certificate and the Registration Rights Agreement dated June 8, 1998
     (collectively, the "Series E Documents") remain in full force and effect
     without amendment or modification, and each party hereto retains all of its
     respective rights and obligations thereunder with respect to the
     outstanding Shares, including, but not limited to, any redemption rights
     currently or hereafter available to Themis Partners L.P. and Heracles Fund.

IN WITNESS WHEREOF, the undersigned have caused this Agreement to be duly
executed effective April 30, 1999.


COCENSYS, INC.


By:       /s/                      
   ----------------------------------------
     Robert R. Holmen
     Vice President and General Counsel


THEMIS PARTNERS L.P.
By:  Promethean Investment Group L.L.C.
Its: General Partner

By:       /s/                      
   ----------------------------------------
     James F. O'Brien, Jr.
     Managing Member

HERACLES FUND
By:  Promethean Investment Group L.L.C.
Its: Investment Advisor

By:       /s/                      
   ----------------------------------------
     James F. O'Brien, Jr.
     Managing Member


                                    Page 13 of 17


<PAGE>

                                                                    EXHIBIT 99.4


Contact:  F. Richard Nichol, Ph.D.           Robert R. Holmen
          CHAIRMAN OF THE BOARD              VICE PRESIDENT AND GENERAL COUNSEL
          PRESIDENT AND CHIEF EXECUTIVE OFFICER

          Donna D. Slade
          ASSISTANT DIRECTOR, INVESTOR RELATIONS/PUBLIC RELATIONS
          949/753-6110

     COCENSYS, INC. AGREES TO SELL ITS HOLDINGS IN CYTOVIA, INC.

     COMPANY USING PROCEEDS TO REPURCHASE SHARES OF ITS SERIES E PREFERRED STOCK

IRVINE, CALIFORNIA/PR NEWSWIRE/MAY 11, 1999 - CoCensys, Inc. (Nasdaq: COCND)
today announced that it has entered into an agreement to sell all of its
stockholdings in Cytovia, Inc., for an aggregate purchase price of $3.3 million.
Consummation of this transaction is subject to certain conditions; however,
CoCensys anticipates closing the transaction in May 1999.  Cytovia was formed in
1998 as a technology spin-off from CoCensys to commercialize apoptosis inhibitor
and screening cell technology; among other rights, CoCensys had retained an
equity stake in Cytovia as part of the spin-off.

The purchasers consist of entities affiliated with Domain Associates, L.L.C., a
venture capital management company.  One of the directors of CoCensys is also a
managing member of Domain Associates, L.L.C., and certain of the entities
purchasing shares of Cytovia from CoCensys currently are stockholders in either
or both of CoCensys and Cytovia.

CoCensys has also entered into agreements with holders of its Series E
Convertible Preferred Stock to repurchase up to 3,180 shares ($3.18 million face
value) of its Series E Preferred Stock, using proceeds from its sale of the
Cytovia shares.  The repurchase price for each share equals the face value
($1,000) plus accrued dividends at 7.5% per annum, plus a 5% premium. 

"We are pleased to have the opportunity to realize substantial value from our
holdings in Cytovia so soon after forming that entity; it is tribute to the
early success that Cytovia has achieved under the guidance of Eckard Weber,
M.D.," said F. Richard Nichol, Ph.D., Chairman of the Board, President and Chief
Executive Officer of CoCensys.  "We believe that our shareholders will benefit
from reducing the amount of outstanding Series E Preferred Stock, and the
holders of that Series E Preferred Stock have been very cooperative in working
with CoCensys to complete this repurchase."

As part of the repurchase agreements, the holders agreed not to convert
additional shares of Series E Preferred Stock prior to July 29, 1999; however,
the holders are entitled to convert if certain conditions apply, including the
following:  (i) CoCensys' common stock is trading above $1.00 per share or at
least 120% of the then-applicable conversion price for the Series E Preferred
Stock; (ii) CoCensys' common stock no longer is trading on the Nasdaq National


                                    Page 14 of 17

<PAGE>

Market or Nasdaq SmallCap Market; or (iii) CoCensys has announced that it is
being sold pursuant to a merger or sale of all or substantially all of its
assets.

Based on the anticipated receipt of proceeds from the sale of the Cytovia
shares, CoCensys has completed repurchase of $1.59 million of Series E Preferred
Stock in exchange for payments totaling $1.8 million.  CoCensys is obligated to
purchase an additional $1.59 million of Series E Preferred Stock on or before
May 20, 1999, upon consummation of sale of its Cytovia shares.  Based on the
shares repurchased to date, as of May 7, 1999, $3.44 million of Series E
Preferred Stock remain outstanding; if CoCensys is able to repurchase the
additional $1.59 million, $1.86 million of Series E Preferred Stock will remain
outstanding at that time.

NASDAQ LISTING

As previously reported, Nasdaq notified CoCensys by letter dated December 1,
1998, that it was not in compliance with the $1.00 minimum closing bid price
requirement for the continued listing of CoCensys' common stock.  A hearing on
this issue was held April 29, 1999.

As of May 10, 1999, Nasdaq had not delisted CoCensys' common stock nor notified
CoCensys of the results of the hearing.  As of May 10, 1999, the minimum closing
bid price for CoCensys' common stock remains below $1.00 per share, and the
market value of CoCensys' common stock held by non-affiliates has fallen below
the $5 million minimum requirement to remain listed on the Nasdaq National
Market.

Based on the outcome of the hearing, CoCensys' shares may continue to trade on
the Nasdaq National Market, CoCensys may be granted a further temporary stay of
delisting, CoCensys' shares may be moved temporarily or permanently to the
Nasdaq SmallCap Market or the shares may be delisted from Nasdaq.  If the shares
are delisted, they likely would be quoted in the "pink sheets" maintained by the
National Quotation Bureau, Inc., or the NASD Electronic Bulletin Board.

CoCensys is a biopharmaceutical company that discovers and develops products for
the treatment of neurological and psychiatric disorders.  CoCensys' product
development programs focus on novel small molecule compounds for the treatment
of epilepsy, anxiety, Parkinson's and other neurodegenerative diseases,
neuropathic pain, migraine, insomnia and stroke.  CoCensys has development
programs with the Wyeth-Ayerst Laboratories Division of American Home Products
Corporation to develop analogs of naturally-occurring neuroactive compounds,
"epalons," for the treatment of anxiety, with Parke-Davis, a division of
Warner-Lambert Company, to identify and develop subtype-selective NMDA receptor
antagonists for the treatment of a variety of neurological and psychiatric
diseases, and with Senju Pharmaceutical and Parke-Davis for the exploration of
ophthalmic indications of CoCensys' glutamate receptor antagonist compounds. 
More information about CoCensys is available on its web site at
www.cocensys.com.

This press release includes forward looking statements that involve a high
degree of financial, technological, regulatory and competitive risks and
uncertainties inherent to early stage 


                                    Page 15 of 17

<PAGE>

biopharmaceutical companies.  These forward looking statements include the
anticipated consummation of the sale of CoCensys' holdings in Cytovia, the
benefit to shareholders of the repurchase of Series E Preferred Stock and the
actions that Nasdaq may take with respect to trading in and the listing of
CoCensys common stock.  Actual results may differ due to a number of factors,
including the following:  closing of sale of CoCensys' holdings in Cytovia
remains subject to conditions not completely within the control of CoCensys;
Nasdaq rules, regulations and procedures may vary or be interpreted differently
in the future; no assurances can be made that the minimum bid price for
CoCensys' common stock will reach or exceed $1.00 per share or that CoCensys
will continue to meet the other requirements to maintain listing of its common
stock on the Nasdaq National Market; and such other factors as discussed in
CoCensys' most recent Form 10-K and Form 10-Q.





                                    Page 16 of 17


<PAGE>

                                                                    EXHIBIT 99.5


Contact:  F. Richard Nichol, Ph.D.            Robert R. Holmen
          CHAIRMAN OF THE BOARD               VICE PRESIDENT AND GENERAL COUNSEL
          PRESIDENT AND CHIEF EXECUTIVE OFFICER        
          
          Donna D. Slade
          ASSISTANT DIRECTOR, INVESTOR RELATIONS/PUBLIC RELATIONS          
     
          949/753-6110

COCENSYS, INC. COMPLETES SALE OF HOLDINGS IN CYTOVIA, INC. AND PARTIAL 
REPURCHASE OF ITS SERIES E PREFERRED STOCK

IRVINE, CALIFORNIA/PR NEWSWIRE/MAY 18, 1999 - CoCensys, Inc. (Nasdaq: COCN)
today announced that it has completed sale of its stockholdings in Cytovia,
Inc., for an aggregate purchase price of $3.3 million.  With the proceeds of the
sale, CoCensys completed its repurchase of an aggregate of 3,180 shares ($3.18
million face value) of its Series E Convertible Preferred Stock.

As previously reported, CoCensys had entered into an agreement to sell its
stockholdings in Cytovia, a technology spin-off from CoCensys formed in 1998,
and into agreements with the holders of its Series E Preferred Stock to
repurchase shares of that Series.  Consummation of each agreement was subject to
certain conditions, which have now been satisfied. 

Following the repurchase, and taking into account recent conversions of the
Series E Preferred Stock, as of May 17, 1999, $1.8 million (including accrued
dividends) of Series E Preferred Stock remains outstanding.  As of that date,
CoCensys had 4.6 million shares of common stock issued and outstanding. 

CoCensys is a biopharmaceutical company that discovers and develops products for
the treatment of neurological and psychiatric disorders.  CoCensys' product
development programs focus on novel small molecule compounds for the treatment
of epilepsy, anxiety, Parkinson's and other neurodegenerative diseases,
neuropathic pain, migraine, insomnia and stroke.  CoCensys has development
programs with the Wyeth-Ayerst Laboratories Division of American Home Products
Corporation to develop analogs of naturally-occurring neuroactive compounds,
"epalons," for the treatment of anxiety, with Parke-Davis, a division of
Warner-Lambert Company, to identify and develop subtype-selective NMDA receptor
antagonists for the treatment of a variety of neurological and psychiatric
diseases, and with Senju Pharmaceutical and Parke-Davis for the exploration of
ophthalmic indications of CoCensys' glutamate receptor antagonist compounds. 
More information about CoCensys is available on its web site at
www.cocensys.com.
                                        ###
                                          
                                          
                                   Page 17 of 17
                                          


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