ENTREMED INC
8-A12G, 1996-05-14
MEDICAL LABORATORIES
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            ------------------------

                                    FORM 8-A

                FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                    PURSUANT TO SECTION 12(b) OR 12(g) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


                                 ENTREMED, INC.
             (Exact name of registrant as specified in its charter)


                   DELAWARE                             58-1959440
(State of incorporation or organization)    (I.R.S. employee identification no.)

9610 MEDICAL CENTER DRIVE, SUITE 200, ROCKVILLE, MARYLAND             20850
(Address of principal executive offices)                            (zip code)

        Securities to be registered pursuant to Section 12(b)of the Act:

Title of each class                        Name of each exchange on
to be so registered                        which each class is to be registered
- ---------------------------                ------------------------------------
- ---------------------------                ------------------------------------


        Securities to be registered pursuant to Section 12(g)of the Act:


                          COMMON STOCK, $.01 PAR VALUE
                    ----------------------------------------
                                (Title of class)

                    ----------------------------------------
                                (Title of class)


C:\BTPM_NY_\1006\0047916.01

                                       -1-
<PAGE>

                 INFORMATION REQUIRED IN REGISTRATION STATEMENT

ITEM 1.  DESCRIPTION OF REGISTRANT'S SECURITIES TO BE REGISTERED.

                  The information called for by this Item 1 is incorporated
                  herein by reference from the Registrant's Registration
                  Statement on Form S-1 (File No. 333-3536) originally filed
                  with the Securities and Exchange Commission on April 12, 1996.

ITEM 2.  EXHIBITS

    1.   Specimen of certificate evidencing Registrant's Common Stock, par value
         $.01.

    2.   (a)  Amended and Restated Certificate of Incorporation of the
              Registrant.*

         (b)  Certificate of Amendment to Amended and Restated Certificate of
              Incorporation of the Registrant.*

         (c)  By-Laws of the Registrant.*








- --------------------------------


*        Filed as an exhibit to the Registrant's Registration Statement on Form 
         S-1 (File No. 333-3536) originally filed with the Commission on April 
         12, 1996.


C:\BTPM_NY_\1006\0047916.01

                                      -2-
<PAGE>
                                    SIGNATURE


                  Pursuant to the requirements of Section 12 of the Securities
Exchange Act of 1934, the Registrant has duly caused this registration statement
to be signed on its behalf by the undersigned, thereto duly authorized.


Date:    May 6, 1996                          ENTREMED, INC.

                                              By:  /S/ John W. Holaday
                                                   --------------------------
                                                   John W. Holaday, Ph.D.
                                                   Chairman, President and
                                                   Chief Executive Officer






C:\BTPM_NY_\1006\0047916.01

                                       -3-

<PAGE>


                                  May 13, 1995


VIA FEDERAL EXPRESS

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549

         Re:  ENTREMED, INC.

Ladies and Gentlemen:

         EntreMed, Inc. (the "Company") hereby respectfully requests that the
Company's Form 8-A, filed with the Commission today, be declared effective by
the Commission concurrently with the effectiveness of the Company's Registration
Statement on Form S-1, originally filed with the Commission on April 12, 1996
(File No. 333-3536).

                                        Sincerely,

                                        ENTREMED, INC.
          

                                         By: /S/ JOHN W. HOLADAY
                                             -----------------------------
                                              John W. Holaday, Ph.D.
                                              Chairman, President and
                                              Chief Executive Officer




                           SPECIMEN STOCK CERTIFICATE


E

                            COMMON STOCK CERTIFICATE


                                 ENTREMED, INC.

   INCORPORATED UNDER THE LAWS                           SEE REVERSE FOR
    OF THE STATE OF DELAWARE                           CERTAIN DEFINITIONS


                                                                         CUSIP


     THIS CERTIFIES THAT
                        -------------------------------------------------
     IS THE OWNER OF
                         -------------------------------

            FULLY PAID AND NON ASSESSABLE SHARES OF THE COMMON STOCK,
                           PAR VALUE $.01 PER SHARE OF
                                 ENTREMED, INC.

(hereinafter the "Corporation") transferable on the books of the Corporation by
 the holder hereof in person or by his duly authorized attorney, upon surrender
                     of this certificate properly endorsed.

                               [GRAPHIC OMITTED]

    This certificate is not valid until countersigned by the Transfer Agent.
   Witness the facsimile seal of the Corporation and the facsimile signatures
                        of its duly authorized officers.

                               [GRAPHIC OMITTED]

                                      SEAL
                                      1991

Dated;


Secretary                                         President


<PAGE>

                                 ENTREMED, INC.

     The Corporation will furnish without charge to each stockholder wo so
requests a statement of the designations, powers, preferences and relative
participating, optional or other special rights of each class of stock or series
thereof of the Corporation and the qualifications, limitations or restrictions
of such preferences and/or rights. Such request may be made to the Corporation
or the Transfer Agent.

     The following abbreviations, when used in the inscription on the face of
this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

TEN COM    --   as tenants in common           
                                                 
TEN ENT     --   as tenants by the entireties  
                                               
JT TEN      --   as joint tenants with right of
                survivorship and not as tenants
                in common

         UNIF GIFT MIN ACT--        _______________ Custodian __________  
                                          (Cust)              (Minor)           
                                    under Uniform Gifts to Minors       
                                    Act ______________                  
                                           (State)                         


Additional abbreviations may also be used though not in the above list.

  For value received, the undersigned hereby sells, assigns and transfers unto


PLEASE INSERT SOCIAL SECURITY OR OTHER
   IDENTIFYING NUMBER OF ASSIGNEE


- --------------------------------------------------------------------------------
  (please print or typewrite name and address, including zip code, of assignee)

- --------------------------------------------------------------------------------

- -------------------------------------- shares of the capital stock represented
by the within Certificate, and do hereby irrevocably constitute and appoint

- ------------------------------------------------ Attorney to transfer the said
stock on the books of the within named Corporation with full power of 
substitution in the premises.


Dated ___________


               ----------------------------------------------
     NOTICE:   THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS
               WRITTEN  UPON THE FACE OF THE  CERTIFICATE  IN EVERY  PARTICULAR,
               WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.




Signature(s) Guaranteed:



- -------------------------------------------------------------------------
THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION
(BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO
S.E.C. RULE 17 Ad-15.

              


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