<PAGE> 1
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. )*
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ENTREMED, INC.
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(Name of Issuer)
Common Stock, $.01 par value
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(Title of Class of Securities)
29382F103
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(CUSIP Number)
Check the following box if a fee is being paid with this statement [X]. (A fee
is not required only if the filing person: (1) has a previous statement on
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)
* The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).
(Continued on following page(s))
Page 1 of 4 Pages
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<PAGE> 2
CUSIP NO. 29382F103 13G PAGE 2 OF 4 PAGES
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<TABLE>
<S> <C> <C> <C>
- -------------------------------------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
John W. Holaday, Ph. D.
###-##-####
- -------------------------------------------------------------------------------------------------------------
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- -------------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- -------------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S.A.
- -------------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
983,568 (see item 4)
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
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6 SHARED VOTING POWER
-0-
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7 SOLE DISPOSITIVE POWER
983,568
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8 SHARED DISPOSITIVE POWER
-0-
- -------------------------------------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
983,568
- -------------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[x]see item 4
- -------------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
7.99%
- -------------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- -------------------------------------------------------------------------------------------------------------
</TABLE>
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 3
Page 3 of 4 Pages
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Item 1(a). Name of Issuer :
ENTREMED, INC.
Item 1(b). Address of Issuer's Principal Executive Offices:
9610 MEDICAL CENTER DRIVE; SUITE 200
ROCKVILLE, MARYLAND 20850
Item 2(a). Name of Person Filing: John W. Holaday, Ph.D.
Item 2(b). Address of Principal Business Office or if none,
Residence:
See item 1(b) above.
Item 2(c). Citizenship: U. S. A.
See item 4 on page 2
Item 2(d). Title of Class of Securities:
Common Stock, $.01 par value ("shares")
Item 2(e). CUSIP Number:
29382F103
Item 3. Not Applicable
Item 4. Ownership:
(a) Amount Beneficially Owned: 983,568 shares. Includes 273,336
shares issuable upon exercise of options which are currently exercisable.
Excludes 208,333 shares issuable upon exercise of options which are not
exercisable within 60 days.
(b) Percent of Class: 7.99%
<PAGE> 4
Page 4 of 4 Pages
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(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 983,568
(ii) shares power to vote or to direct the vote: -0-
(iii) sole power to dispose or to direct the disposition of:
983,568
Item 5. Ownership of Five Percent or Less of a Class
Not Applicable
Item 6. Ownership of More than Five Percent on Behalf of Another Person
Not Applicable
Item 7. Identification and Classification of Subsidiary Which Acquired
the Securities
Not Applicable
Item 8. Identification and Classification of Members of the Group
Not Applicable
Item 9. Notice of Dissolution of Group
Not Applicable
Item 10. Certification
Not Applicable
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
February 13, 1997
By: /s/ John W. Holaday, Ph. D.
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John W. Holaday, Ph. D.
