ENTREMED INC
SC 13D/A, 1999-04-13
MEDICAL LABORATORIES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)

                    INFORMATION TO BE INCLUDED IN STATEMENTS
                 FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS
                     THERETO FILED PURSUANT TO RULE 13d-2(a)
                               (Amendment No. 3)1

                                 ENTREMED, INC.
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                                (Name of Issuer)

                     COMMON STOCK, PAR VALUE $0.01 PER SHARE
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                         (Title of Class of Securities)

                                    29382F103
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                                 (CUSIP Number)

                   TODD J. PETERS, MILLS VALUE ADVISER, INC.,
          707 EAST MAIN STREET, RICHMOND, VIRGINIA 23219 (804) 344-3804
- --------------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                 MARCH 18, 1999
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             (Date of Event which Requires Filing of this Statement)

         If the filing person has  previously  filed a statement on Schedule 13G
to report the  acquisition  that is the  subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d-1(e),  13d-1(f) or 13d-1(g),  check the
following box |_|.

         Note:  Schedules  filed in paper format shall include a signed original
and five copies of the schedule,  including all exhibits.  See Rule 13d-7(b) for
other parties to whom copies are to be sent.


                         (Continued on following pages)

                               (Page 1 of 7 Pages)




         1 The  remainder of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934, as amended (the "Act"),  or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other  provisions of the Act
(however, see the Notes).

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<PAGE>

- ---------------------------                          ---------------------------
    CUSIP No. 29382F103          SCHEDULE 13D             Page 2 of 7 Pages
- ---------------------------                          ---------------------------

- --------- ----------------------------------------------------------------------
1         NAME OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          James T. Martin
- --------- ----------------------------------------------------------------------
2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)    |_|
                                                                      (b)    |_|
          Not Applicable
- --------- ----------------------------------------------------------------------
3         SEC USE ONLY


- --------- ----------------------------------------------------------------------
4         SOURCE OF FUNDS*

          PF
- --------- ----------------------------------------------------------------------
5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
          ITEM 2(d) or 2(e)                                                  |_|

          Not Applicable
- --------- ----------------------------------------------------------------------
6         CITIZENSHIP OR PLACE OF ORGANIZATION

          Bermuda
- ------------------------- ------- ----------------------------------------------
       NUMBER OF          7       SOLE VOTING POWER

         SHARES                   520,090
                          ------- ----------------------------------------------
                          8       SHARED VOTING POWER
      BENEFICIALLY
                                  -0-
                          ------- ----------------------------------------------
     OWNED BY EACH        9       SOLE DISPOSITIVE POWER

       REPORTING                  -0-
                          ------- ----------------------------------------------
                          10      SHARED DISPOSITIVE POWER
      PERSON WITH
                                  -0-
- ------------------------- ------- ----------------------------------------------
11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          520,090
- --------- ----------------------------------------------------------------------
12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                             |_|
          Not Applicable
- --------- ----------------------------------------------------------------------
13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          4.0%
- --------- ----------------------------------------------------------------------
14        TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                 AMENDMENT NO. 3
                                       TO
                                  SCHEDULE 13D
                                       FOR
                                 JAMES T. MARTIN


         This  Amendment  No. 3 hereby amends and  supplements  the Schedule 13D
(the  "Schedule  13D"),  dated January 11, 1999,  filed with the  Securities and
Exchange  Commission  on January 29, 1999,  Amendment No. 1 to the Schedule 13D,
dated  January  27,  1999,  filed with the  Commission  on  February 4, 1999 and
Amendment No. 2 to the Schedule  13D,  dated  February 16, 1999,  filed with the
Commission on February 26, 1999  ("Amendment  No. 2") with respect to the common
stock,  par value $0.01 per share  ("Common  Stock"),  of  EntreMed,  Inc.  (the
"Issuer").

Item 1.     Security and Issuer

            This  Amendment No. 3 relates to the common  stock,  par value $0.01
            per share, of EntreMed,  Inc., 9610 Medical Center Drive, Suite 200,
            Rockville, Maryland 20850.

Item 2.     Identity and Background

            (A)     James T. Martin

            (B)     Tuppeny House
                    Tuckerstown, Bermuda

            (C)     James T. Martin is a lecturer, author and consultant.

            (D)     During  the past five  years,  James T.  Martin has not been
                    convicted  in  a  criminal  proceeding,   excluding  traffic
                    violations or similar misdemeanors.

            (E)     During the past five  years,  James T. Martin has not been a
                    party to a civil proceeding of a judicial or  administrative
                    body of competent jurisdiction and has not been subject to a
                    judgment,  decree or final order enjoining future violations
                    of, or  prohibiting  or  mandating  activities  subject  to,
                    federal or state  securities  laws or finding any  violation
                    with respect to such laws.

            (F)     James T.  Martin is a citizen of Bermuda  (subject  of Great
                    Britain).



                               Page 3 of 7 Pages
<PAGE>



Item 3.     Source and Amount of Funds and Other Consideration

            The total amount of the funds used in making purchases of the shares
            of  Common  Stock   beneficially   owned  by  James  T.  Martin  was
            $14,574,517.  The sources of the funds used in making the  purchases
            were personal funds.

Item 4.     Purpose of Transaction

            James T. Martin has purchased  shares of Common Stock for investment
            purposes.

            There are no plans or proposals  which James T. Martin may have that
            relate to or would result in:

            (A)     The  acquisition  by any person of additional  securities of
                    the Issuer,  or the disposition of securities of the Issuer,
                    except as otherwise disclosed herein;

            (B)     An extraordinary  corporate  transaction,  such as a merger,
                    reorganization  or liquidation,  involving the Issuer or any
                    of its subsidiaries;

            (C)     A sale or  transfer  of a  material  amount of assets of the
                    Issuer or of any of its subsidiaries;

            (D)     Any change in the present  board of directors or  management
                    of the Issuer,  including  any plans or  proposals to change
                    the  number  or term of  directors  or to fill any  existing
                    vacancies on the board;

            (E)     Any  material  change  in  the  present   capitalization  or
                    dividend policy of the Issuer;

            (F)     Any  other  material  change  in the  Issuer's  business  or
                    corporate structure;

            (G)     Changes  in the  Issuer's  charter,  bylaws  or  instruments
                    corresponding  thereto or other actions which may impede the
                    acquisition of control of the Issuer by any person;



                               Page 4 of 7 Pages
<PAGE>

            (H)     Causing a class of  securities  of the Issuer to be delisted
                    from  a  national  securities  exchange  or to  cease  to be
                    authorized to be quoted in an inter-dealer  quotation system
                    of a registered national securities association;

            (I)     A class of equity securities of the Issuer becoming eligible
                    for termination of registration pursuant to Section 12(g)(4)
                    of the Securities Exchange Act of 1934, as amended; or

            (J)     Any action similar to any of those enumerated above.

Item 5.     Interest in Securities of the Issuer

            (A)     The  aggregate   number  and   percentage  of  Common  Stock
                    beneficially owned by James T. Martin are 520,090 Shares and
                    4.0%, respectively.

            (B)     James T.  Martin has the sole power to vote or to direct the
                    vote of all the shares identified pursuant to Item 5(a). Mr.
                    Martin  does not have any power to  dispose or to direct the
                    disposition  of all the shares  identified  pursuant to Item
                    5(a).

            (C)     Transactions in the securities  identified  pursuant to Item
                    5(a) since the date of the event that required the filing of
                    Amendment No. 2 are as follows:

    Beneficial      Transaction       Amount of      Price Per       Where/How
      Owner             Date         Transaction       Share         Effected

   J.T. Martin        02/17/99         $97,694*        $19.53        Open Market
   J.T. Martin        02/18/99         $97,494*        $19.49        Open Market
   J.T. Martin        02/19/99         $87,182*        $17.43        Open Market
   J.T. Martin        02/22/99         $82,845*        $16.56        Open Market
   J.T. Martin        02/23/99         $86,245*        $17.24        Open Market
   J.T. Martin        02/24/99        $102,244*        $20.44        Open Market
   J.T. Martin        02/25/99         $97,963*        $19.59        Open Market
   J.T. Martin        02/26/99         $92,244*        $18.44        Open Market
   J.T. Martin        03/01/99         $89,745*        $17.94        Open Market
   J.T. Martin        03/02/99         $93,374*        $18.67        Open Market
   J.T. Martin        03/03/99        $105,307*        $21.06        Open Market
   J.T. Martin        03/04/99        $105,744*        $21.14        Open Market
   J.T. Martin        03/05/99        $100,229*        $20.04        Open Market
   J.T. Martin        03/08/99        $104,149*        $20.82        Open Market
   J.T. Martin        03/09/99        $109,994*        $21.99        Open Market
   J.T. Martin        03/10/99        $119,369*        $23.87        Open Market




                               Page 5 of 7 Pages
<PAGE>

    Beneficial      Transaction       Amount of      Price Per       Where/How
      Owner             Date         Transaction       Share         Effected

   J.T. Martin        03/11/99        $122,493*        $24.49        Open Market
   J.T. Martin        03/12/99        $120,931*        $24.18        Open Market
   J.T. Martin        03/15/99        $123,693*        $24.73        Open Market
   J.T. Martin        03/16/99        $130,149*        $26.02        Open Market
   J.T. Martin        03/17/99        $102,044*        $20.40        Open Market
   J.T. Martin        03/18/99        $107,244*        $21.44        Open Market

                                  *Denotes sale

            (D)     Not applicable.

            (E)     James T. Martin  ceased to be the  beneficial  owner of more
                    than five percent of the outstanding  shares of Common Stock
                    on or about February 18, 1999.


Item 6.     Contracts,   Arrangements,   Understandings  or  Relationships  with
            Respect to Securities of the Issuer

            None


Item 7.     Material to be Filed as Exhibits

            None




                               Page 6 of 7 Pages
<PAGE>

                                   SIGNATURES

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify  that the  information  set forth in this  statement  on Schedule 13D is
true, complete and correct.




Date:  March 18, 1999                       /s/ James T. Martin                 
                                            ------------------------------------
                                            James T. Martin




Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
            criminal violations (see 18 U.S.C. 1001).



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