ENTREMED INC
10-K405/A, 1999-04-30
MEDICAL LABORATORIES
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================================================================================

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 10-K
                                (Amendment No. 2)

              ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934
                   For the fiscal year ended December 31, 1998

                         Commission file number 0-20713

                                 EntreMed, Inc.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)


      Delaware                                            58-1959440
- ------------------------                    ------------------------------------
(State of Incorporation)                    (I.R.S. Employer Identification No.)


Suite 200, 9610 Medical Center Drive, Rockville, MD                    20850
- ---------------------------------------------------                 ----------
     (Address of principal executive offices)                       (Zip Code)


Registrant's telephone number, including area code:   (301) 217-9858

Securities registered pursuant to Section 12(g) of the Act:

         Title of Each Class                Name of Exchange on Which Registered
- --------------------------------------      ------------------------------------
Common Stock, Par Value $.01 Per Share               Nasdaq National Market


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes X  No

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405
of Regulation S-K is not contained herein, and will not be contained, to the
best of registrant's knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this form 10-K or any amendment to this
Form 10-K [X]

As of March 25, 1999, 13,138,328 shares of common stock were outstanding and the
aggregate market value of the shares of common stock held by non-affiliates was
approximately $278,027,000.

================================================================================

<PAGE>

                                EXPLANATORY NOTE:
                                -----------------

         This Amendment No. 1 to the Form 10-K for the fiscal year ended
December 31, 1998 is filed solely to add Part III of Form 10-K, which was
omitted in reliance on General Instruction G.3 thereto.

                                    PART III

Item 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

         The following table sets forth the names, ages and positions of the
executive officers and directors of the Company:

NAME                             AGE             POSITION
- ----                             ---             --------

John W. Holaday, Ph.D. (1)        53    Chairman of the Board, President, Chief
                                        Executive Officer and Director

Edward R. Gubish, Ph.D.           50    Senior Vice President, Research and
                                        Development

R. Nelson Campbell                34    Chief Financial Officer

John C. Thomas, Jr.               45    Secretary/Treasurer

Donald S. Brooks (2)              63    Director

Samuel R. Dunlap, Jr. (1)(2)      49    Executive Advisor and Director

Lee F. Meier (2)(3)               51    Director

Mark C.M. Randall (3)             36    Director

Wendell M. Starke (1)             56    Vice Chairman and Director

Jerry Finkelstein (3)             83    Director


- ----------
(1) Member of Executive Committee; (2) Member of Compensation Committee;
(3) Member of Audit Committee

         John W. Holaday, Ph.D. is a co-founder of the Company and has served as
its President and Chief Executive Officer and a director since August 1992 and
its Chairman of the Board since November 1995. Prior thereto, from May 1989 to
August 1992, he was a co-founder of Medicis Pharmaceutical Corp. where he served
as Scientific Director, Senior Vice President for


                                       2
<PAGE>

Research and Development and director. Dr. Holaday also serves as a director for
CytImmune Sciences, Inc., a privately held research diagnostics company. From
1968 to 1989, he served at the Walter Reed Army Institute of Research, where he
founded the Neuropharmacology Branch in 1980. He serves as an officer and fellow
in several biomedical societies and has authored and edited numerous scientific
articles in journals and books. His current academic positions include Associate
Professor of Anesthesiology and Critical Care Medicine and Senior Lecturer in
Medicine at The Johns Hopkins University of Medicine, Baltimore, Maryland;
Adjunct Professor of Pharmacology and Psychiatry at the Uniformed Services
University School of Medicine, Bethesda, Maryland; and Clinical Assistant
Professor of Surgery at the University of Connecticut Health Center, Farmington,
Connecticut.

         Edward R. Gubish, Ph.D. has served as Senior Vice President of Research
and Development since January 1997, prior to that he served as Vice President -
Regulatory and Clinical Development of the Company since November 1995 and has
been employed by the Company since October 1993. From 1990 to September 1993,
Dr. Gubish served as senior director of Regulatory Affairs for Baker Norton
Pharmaceuticals (IVAX) and Fujisawa Pharmaceuticals. From 1986 to 1990, Dr.
Gubish served as Chief of Regulatory Affairs for the AIDS Division at the
National Institutes of Health and as a scientific and administrative contact for
sponsors of new biological products and IND submissions for the Center for Drugs
and Biologics at the FDA.

         R. Nelson Campbell has served as Chief Financial Officer since January
1997. From November 1991 to June 1996, Mr. Campbell was employed by
OsteoArthritis Sciences, Inc., a venture capital financed drug discovery company
where he was a co-founder and served as Vice President of Business Development
and Treasurer. From 1986 to 1991, he was with the international investment
banking firms of Merrill Lynch Capital Markets, Nomura Securities International
and lastly Daiwa America Securities, Inc., where he was engaged in corporate
finance and merger transactions.

         John C. Thomas, Jr. has served as Secretary/Treasurer since January
1997 and served part-time as Chief Financial Officer of the Company from its
inception in September 1991 until January 1997. Mr. Thomas has also served as
the Chief Financial Officer of several other companies, including MEDigital,
Inc., a private medical technology company since August 1996, Credit Depot
Corporation, a public company engaged in loan financing (from August 1990 to
March 1993 and from January 1995 until April 1996), Tapistron International,
Inc., a public company engaged in the development of technology for the textile
industry (from August 1991 until July 1995), and Sealite Sciences, a private
biotechnology company (from June 1991 to March 1993). Mr. Thomas is a certified
public accountant.

         Donald S. Brooks has been a director of the Company since April 1996.
Since July 1993, Mr. Brooks has been a practicing attorney with the law firm
Carella Byrne Bain Gilfillan Cecchi Stewart & Olstein, Roseland, New Jersey,
which represents the Company on certain matters. Prior thereto, Mr. Brooks was
employed by Merck & Co., Inc. for 27 years, most recently, from 1986 to 1993, as
Senior Counsel. From 1980 to 1985, Mr. Brooks served as a U.S. employer delegate
to the Chemical Industries Committee, International Labor Organization in
Geneva, Switzerland.


                                       3
<PAGE>

         Samuel R. Dunlap, Jr. has served as an Executive Advisor and a director
to the Company since August 1992. Mr. Dunlap also has (i) served as Chairman of
Dunlap & Partners, Ltd., a financial consulting firm in Atlanta, Georgia, since
October 1988, (ii) served as a director of Credit Depot Corporation, of which he
was a founder, since December 1986, (iii) served as Vice President of MEDigital,
Inc. since August 1996, (iv) from 1992 through 1996 served as a director to
First Pacific Networks, Inc., a publicly-held telecommunications company, (v)
served as a director and a consultant of Golf Training Systems, Inc., a public
company, from August 1994 until December 1995 and (vi) served as a director from
July 1991 until February 1994 and an Executive Advisor from July 1991 until
November 1994 of Tapistron International, Inc. From April 1986 until December
1988, Mr. Dunlap served as Executive Vice President and director of CytRx
Corporation, a publicly-held pharmaceutical company of which he was a founder.
Mr. Dunlap also served as Executive Vice President of Elan Pharmaceutical
Research Corp., a publicly-held company, from August 1982 to December 1983 and
President and a director of such entity from January 1984 to January 1985. Mr.
Dunlap will not seek reelection after the expiration of his present term as a
director.

         Lee F. Meier has been a director of the Company since July 1997. Mr.
Meier has over twenty years of experience in the equipment financing industry.
He has been affiliated with US Leasing Corporation, The Chemical Bank of New
York and Steiner Financial Corporation, a privately held, tax motivated lessor.
Since 1984 Mr. Meier has served as founder and managing director of Meier
Mitchell & Company, an investment banking firm specializing in providing
innovative debt and lease financing products. Meier Mitchell & Company targets
clients in the biotechnology and electronics industries and has arranged or
provided well over $1 billion in financing to both private and public companies
in these sectors.

         Mark C.M. Randall has been a director of the Company since April 1996.
Since 1985, Mr. Randall has been associated with Sarasin International
Securities Limited, London, England, a wholly-owned subsidiary of Bank Sarasin &
Cie, a private bank based in Switzerland, where he has been Director since 1994.

         Wendell M. Starke has been Vice Chairman of the Board since June 1998
and a director of the Company since April 1994. Mr. Starke is a Chartered
Financial Analyst and a Chartered Investment Counselor. Mr. Starke was President
of INVESCO Capital Management, Inc. and Chief Investment Officer from 1979 to
1991. In 1992, he became Chairman of INVESCO, Inc., the parent company of
INVESCO Capital Management and other INVESCO money management subsidiaries in
the United States. Mr. Starke also serves as a member of the Board and as Global
Chief Investment Officer of AMVESCAP, PLC. the London-based parent company of
the worldwide INVESCO organization.

         Jerry Finkelstein has been a director of the Company since April 1998.
Mr. Finkelstein has been a senior advisor to Apollo Advisors, L. P., a fund
manager, since March 1994, and the Chairman of the Board of News Communications,
Inc., a consortium of 23 publications, since August 1993. Mr. Finkelstein has
been the former publisher of the New York Law Journal, a daily newspaper. He has
been a member of the Boards of Rockefeller Center, Chicago Milwaukee
Corporation, Chicago Milwaukee Railroad Corporation, Bank of North America,


                                       4
<PAGE>

Struthers Wells Corporation, The Hill, and PATH Railroad. Mr. Finkelstein has
also held the following positions: member of Task Force Committee on the sale of
the World Trade Center; Chairman of the New York City Planning Commission, and
Commissioner of the Port Authority of New York and New Jersey, as well as
numerous civic, social and political appointments.

Item 11. EXECUTIVE COMPENSATION

         Compensation of Directors

         Directors of the Company received a fee of $2,000 per in-person meeting
attended and were reimbursed for expenses actually incurred in connection with
attending such meetings. Directors were also awarded initial grants of
non-qualified stock options to purchase 15,000 shares of Common Stock upon
joining the Board of Directors and annual grants of non-qualified stock options
to purchase 5,000 shares of Common Stock. In addition, each member of the Audit
Committee and the Compensation Committee received annual grants of non-qualified
stock options to purchase 1,000 shares of Common Stock. All such automatic
grants were awarded on July 1, 1998.

         The Company granted non-qualified stock options to purchase 100,000
shares of Common Stock to Wendell M. Starke in April 1998 upon Mr. Starke's
election as Vice Chairman of the Board. The options have an exercise price of
$12.00 per share, the fair market value of a share of Common Stock on the date
of grant, and were immediately exercisable.  This grant is in addition to the
automatic grant of stock options Mr. Starke received as a member of the Board of
Directors.

         The Company entered into a three year consulting agreement with Samuel
R. Dunlap, Jr. commencing January 1, 1996 that provides for annual payments of
$90,000.

         Compensation of Executive Officers

         The following summary compensation table sets forth the aggregate
compensation paid or accrued by the Company to the Chief Executive Officer and
to executive officers whose annual compensation exceeded $100,000 for fiscal
1998 (collectively, the "named executive officers") for services during the
fiscal years ended December 31, 1998, 1997 and 1996.

                           Summary Compensation Table

<TABLE>
<CAPTION>
                                                                                     Long Term
                                                                                    Compensation
                                                                                       Awards
                                                                                     Securities
                                                            Annual                   Underlying        All Other
                                                            Salary        Bonus     Options/SARs     Compensation
Name and Principal Position               Year                ($)          ($)         (No.)             ($)

<S>                                       <C>               <C>          <C>          <C>              <C>      
John W. Holaday, Ph.D.                    1998              250,000      125,000        5,000          19,467(1)
     Chairman, President and Chief        1997              275,000         -         260,000          18,883
     Executive Officer                    1996              250,000       80,000      105,000          18,221


                                       5
<PAGE>

Edward R. Gubish, Ph.D.                   1998              180,000       75,000         -              6,916(2)
     Vice President, Regulatory           1997              165,000       50,000      100,000           6,332
     and Clinical Development             1996              140,000       42,000       75,000           5,670

R. Nelson Campbell                        1998              147,000       20,000         -              1,849(2)
     Chief Financial Officer              1997              133,718       25,000       50,000           1,301
                                          1996                 -            -            -                -

John C. Thomas, Jr.                       1998              126,000       10,000         -              6,916(2)
     Secretary/Treasurer                  1997              120,000       25,000       50,000             -
                                          1996               96,880       21,500       38,000             -
</TABLE>

(1)      $12,551 of such amount represents the premiums paid by the Company with
         respect to a split-dollar life insurance policy on the life of Dr.
         Holaday. Premiums paid by the Company on such policy are treated as
         non-interest bearing advances to the insured for the policy. The
         initial proceeds of any death benefit are required to be used to repay
         the indebtedness, and the balance of the insurance proceeds are payable
         as designated by the insured. See "Employment Contracts and Termination
         of Employment and Change-in-Control Arrangements". The remaining amount
         represents group health insurance premiums paid on behalf of such
         officer.

(2)      Consists of group health insurance premiums paid on behalf of such
         officer.

         The following table sets forth certain information with respect to
individual grants of stock options and warrants made during the fiscal year
ended December 31, 1998 to each of the named executive officers.

                      Option/SAR Grants in Last Fiscal Year

<TABLE>
<CAPTION>
                                Number of
                                Securities       % of Total                                     Potential Realizable
                                Underlying      Options/SARs                                      Value at Assumed
                                 Options/        Granted to      Exercise or                    Annual Rates of Stock
                                   SARs         Employees in      Base Price     Expiration     Price Appreciation for
            Name                 Granted         Fiscal Year       ($/sh)          Date              Option Term(1)
                                                                                                  5% ($)       10% ($)

<S>                               <C>               <C>            <C>           <C>             <C>           <C>    
John W. Holaday, Ph.D.            5,000             1.47%          31.9375       6/26/2008       260,114       414,188

</TABLE>

(1)      Calculated by multiplying the exercise price by the annual appreciation
         rate shown (as prescribed by SEC rules and compounded for the term of
         the options), subtracting the exercise price per share and multiplying
         the gain per share by the number of shares covered by the options.
         These amounts are not intended to forecast possible future
         appreciation, if any, of the price of the Company's Shares. The actual
         value realized upon exercise of the options to purchase Company Shares
         will depend on the fair market value of the Company's Shares on the
         date of exercise.

         The following table sets forth information concerning all option
holdings for the fiscal year ended December 31, 1997 for each of the named
executive officers.


                                       6
<PAGE>

           Aggregated Option and Warrant/Exercises in Last Fiscal Year
                             and FY-End Option/Value

<TABLE>
<CAPTION>
                                                                   Number of Securities            Value of Unexercised    
                                                                    Underlying Options             In-the Money Options    
                                                                   at Fiscal Year-End($)          at Fiscal Year-End($)(2) 
                        Shares Acquired          Value          ---------------------------    ----------------------------
Name                    on Exercise (#)     Realized($)(1)      Exercisable   Unexercisable    Exercisable    Unexercisable
- ----                    ---------------     --------------      -----------   -------------    -----------    -------------
<S>                          <C>           <C>                    <C>            <C>            <C>              <C>    
John W. Holaday, Ph.D.         -                  -               529,169        25,000         7,305,031        175,000
Edward R. Gubish, Ph.D.      40,000          1,045,000            176,250        68,750         1,967,500        681,250
R. Nelson Campbell            5,000             65,438             76,250        43,750           633,750        406,250
John C. Thomas, Jr.            -                  -               125,769        34,500         1,856,626        341,500

</TABLE>

(1)      The Value Realized represents the amount equal to the excess of the
         fair market value of the shares at the time of exercise over the
         exercise price.
(2)      Calculated by multiplying the number of unexercised options outstanding
         at December 31, 1998 by the difference between the fair market value of
         the Company's Shares at December 31, 1998 ($21.00) and the option
         exercise price.

             Employment Contracts and Termination of Employment and
                         Change-In-Control Arrangements

         In April 1996, effective as of January 1, 1996, the Company entered
into a three-year employment agreement with John W. Holaday, Ph. D., Chairman
and Chief Executive Officer of the Company. The agreement provided for an annual
base salary of $250,000 per year. Effective January 1999, the Company entered
into a new three year employment agreement with Dr. Holaday as the Chairman and
Chief Executive Officer of the Company with an annual base salary of $325,000
per year and a minimum annual increase of 10% per year. The Company may
terminate the agreement without cause and, upon such termination, Dr. Holaday
will be entitled to receive his base salary through the end of the initial term
of the agreement (subject to an offset for salary received from subsequent
employment). The agreement contains confidentiality and non-competition
provisions.

         The Company maintains a $2,000,000 split-dollar life insurance policy
on the life of Dr. Holaday at an annual cost of approximately $12,551. Premiums
paid by the Company on such policy are treated as non-interest bearing advances
to the insured for the policy. The initial proceeds of any death benefit are
required to be used to repay the indebtedness, and the balance of the insurance
proceeds are payable as designated by the insured.

         Each of the Company's employees has entered into a Proprietary
Information and Invention Assignment Agreement providing, among other things,
that such employee will not disclose any confidential information or trade
secrets in any unauthorized manner and that all inventions of such officer
relating to the Company's current or anticipated business during the term of
employment become the Company's property.

         In the event of certain transactions, including those which may result
a change in control, as defined under the Company's Incentive Stock Option
Plans, unvested installments of options to purchase Shares of the Company may
become immediately exercisable.


                                       7
<PAGE>

Section 16(a) Beneficial Ownership Reporting Compliance

         Section 16(a) of the 1934 Act requires the Company's executive
officers, directors and persons who beneficially own more than 10% of a
registered class of the Company's equity securities to file with the S.E.C.
initial reports of ownership and reports of changes in ownership of common stock
and other equity securities of the Company. Such executive officers, directors,
and greater than 10% beneficial owners are required by S.E.C. regulation to
furnish the Company with copies of all Section 16(a) forms filed by such
reporting persons.

         Based solely on the Company's review of such forms furnished to the
Company and written representation from certain reporting persons, the Company
believes that all filing requirements applicable to the Company's executive
officers, directors and greater than 10% beneficial owners were complied with.

Compensation Committee Interlocks and Insider Participation


         During fiscal 1998, the members of the Compensation Committee were: Lee
F. Meier, Mark C. M. Randall, and Wendell M. Starke.

         Wendell M. Starke is the Chairman of INVESCO, Inc. and previously
served as a member of the Board and Global Chief Investment Officer of AMVESCAP,
the London-based parent company of the worldwide INVESCO organization, which
provides certain investment advisory services to the Company. 


Item 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth, as of April 20, 1999 (except as
otherwise footnoted below), certain information concerning stock ownership of
all persons known by the Company to own beneficially more than 5% of the Shares,
each director or director nominee, each executive officer named under "Executive
Compensation and Other Matters" and all directors and executive officers of the
Company as a group.

                                      Amount and Nature of        Percentage of
        Name of Stockholder (1)     Beneficial Ownership (1)   Outstanding Class
John W. Holaday, Ph.D.                    1,316,400  (2)             9.86%
Donald S. Brooks                            137,251  (3)             1.04%
R. Nelson Campbell                           78,749  (4)              *
Samuel R. Dunlap, Jr.                       408,612  (5)             3.11%
Jerry Finkelstein                           107,500  (6)              *
Edward R. Gubish, Ph. D.                    193,500  (7)             1.46%
Lee F. Meier                                 49,000  (8)              *
Mark C. M. Randall                           71,334  (9)              *
Wendell M. Starke                           398,366 (10)             3.03%


                                        8
<PAGE>

John C. Thomas, Jr.                         127,350 (11)              *
Bristol-Myers Squibb Company                874,999 (12)             6.65%
    P. O. Box 4000
    Princeton, New Jersey 08543
Mills Value Advisor, Inc.                   670,543 (13)             5.10%
    c/o Todd J. Peters
    Mills Value Advisor, Inc.
    707 East Main Street
    Richmond, Virginia 23219
All executive officers and directors     2,888,062  (14)            21.35%
    of the Company as a group
    (10 persons)

- ----------
*Less than 1%

(1)      Beneficial ownership is defined in accordance with the rules of the
         Securities and Exchange Commission ("SEC") and generally means the
         power to vote and/or to dispose of the securities regardless of any
         economic interest therein.
(2)      Includes 609,168 shares issuable upon exercise of options and warrants
         which are exercisable within 60 days and 126,666 shares held by a
         limited partnership of which Dr. Holaday is the general partner. Does
         not include 187,501 shares issuable upon exercise of options not
         exercisable within 60 days.
(3)      Includes 137,251 shares issuable upon exercise of options which are
         exercisable within 60 days.
(4)      Includes 51,251 shares issuable upon exercise of options which are
         exercisable within 60 days.
(5)      Includes 350,282 shares issuable upon exercise of options which are
         exercisable within 60 days.
(6)      Includes 71,000 shares issuable upon exercise of options and warrants
         which are exercisable within 60 days. Does not include shares held by
         various family members of Mr. Finkelstein, as to which Mr. Finkelstein
         disclaims beneficial ownership.
(7)      Includes 182,500 shares issuable upon exercise of options which are
         exercisable within 60 days. Does not include 87,500 shares issuable
         upon exercise of options not exercisable within 60 days.
(8)      Includes 24,000 shares issuable upon exercise of options which are
         exercisable within 60 days and 25,000 shares issuable upon exercise of
         warrants which are exercisable within 60 days held by an entity the
         general partner of which is an entity in which Mr. Meier serves as
         Managing Director.
(9)      Includes 71,334 shares issuable upon exercise of options which are
         exercisable within 60 days. Does not include 6,667 shares issuable upon
         exercise of options not exercisable within 60 days.

                                       9

<PAGE>


(10)     Includes 189,815 shares issuable upon exercise of options and warrants
         which are exercisable within 60 days. Does not include 40,761 shares
         owned by various family members of Mr. Starke, as to which Mr. Starke
         disclaims beneficial ownership.
(11)     Includes 127,018 shares issuable upon exercise of options and warrants
         which are exercisable within 60 days. Does not include 38,251 shares
         issuable upon exercise of options not exercisable within 60 days.
(12)     Based on Schedule 13G filed by Bristol-Myers Squibb Company on December
         21, 1998.
(13)     Based on Amendment No. 4 to the Schedule 13D filed by Mills Value
         Advisor, Inc. on April 13, 1999. Includes 40,000 shares beneficially
         owned by Mills Value Advisor, Inc. together with shares held by Mills
         Value Advisor, Inc in an investment advisory service capacity whereby
         Mills Value Advisor, Inc. has the sole discretion to dispose of such
         shares.
(14)     Includes 1,856,286 shares issuable upon exercise of options and
         warrants which are exercisable within 60 days. Does not include 371,170
         shares issuable upon exercise of options not exercisable within 60
         days.

Item 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         The Company entered into a three year consulting agreement with Samuel
R. Dunlap, Jr. commencing January 1, 1996 that provides for annual payments of
$90,000.

         Leon E. Rosenberg, M.D., a director of the Company until March 3, 1998,
was the Senior Vice President, Scientific Affairs of Bristol-Myers Squibb
Company. In December 1995, the Company and Bristol-Myers Squibb entered into a
collaboration to develop and commercialize certain antiangiogenesis
therapeutics. Pursuant to this collaboration, Bristol-Myers Squibb paid to the
Company during fiscal 1997 an aggregate of approximately $3,670,000 in research
funding and reimbursements for certain clinical trials and certain research and
development and know-how.

         Donald S. Brooks, a director of the Company, was of counsel to the law
firm Carella, Byrne, Bain, Gilfillan, Cecchi , Stewart & Olstein, which provides
certain legal services to the Company, prior to becoming the Vice President -
Legal Affairs at the Company in 1998.


                                       10
<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Section 13 or 15(d) of the
Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned, thereunto duly authorized.


                                    ENTREMED, INC.


                                By: /s/ John W. Holaday
                                    --------------------------------------------
                                    John W. Holaday, Ph.D., Chairman of the
                                    Board, President and Chief Executive Officer

                                    April 29, 1999

         Pursuant to the requirements of the Securities Act of 1934, this report
has been signed below by the following persons in the capacities and on the
dates indicated.

        Signature                         Title                  Date
        ---------                         -----                  ----

/s/ John W. Holaday             Chairman of the Board and       4/29/99
- --------------------------       Chief Executive Officer
John W. Holaday, Ph. D.       (principal executive officer)

/s/ R. Nelson Campbell           Chief Financial Officer        4/29/99
- --------------------------      (principal financial and
R. Nelson Campbell                 accounting officer)

/s/ John C. Thomas, Jr.            Secretary/Treasurer          4/29/99
- --------------------------
John C. Thomas, Jr.


                                        Director                
- --------------------------
Donald S. Brooks


/s/ Samuel R. Dunlap, Jr.               Director                4/29/99
- --------------------------
Samuel R. Dunlap, Jr.


/s/ Jerry Finkelstein                   Director                4/29/99
- --------------------------
Jerry Finkelstein


/s/ Lee F. Meier                        Director                4/29/99
- --------------------------
Lee F. Meier


/s/ Mark C. M. Randall                  Director                4/29/99
- --------------------------
Mark C. M. Randall


/s/ Wendell M. Starke                   Director                4/29/99
- --------------------------
Wendell M. Starke


                                       11




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