ENERGY BIOSYSTEMS CORP
DEF 14A, 1997-04-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>
 
                           SCHEDULE 14A INFORMATION

          Proxy Statement Pursuant to Section 14(a) of the Securities
                    Exchange Act of 1934 (Amendment No.  )
        
Filed by the Registrant [x]

Filed by a Party other than the Registrant [_] 

Check the appropriate box:

[_]  Preliminary Proxy Statement        [_]  Confidential, for Use of the 
                                             Commission Only (as permitted by
                                             Rule 14a-6(e)(2))
[X]  Definitive Proxy Statement 

[_]  Definitive Additional Materials 

[_]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                         ENERGY BIOSYSTEMS CORPORATION
- - --------------------------------------------------------------------------------
               (Name of Registrant as Specified In Its Charter)


- - --------------------------------------------------------------------------------
   (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

   
Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.

[_]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

   
     (1) Title of each class of securities to which transaction applies:

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     (2) Aggregate number of securities to which transaction applies:

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     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
         the filing fee is calculated and state how it was determined):

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     (4) Proposed maximum aggregate value of transaction:

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     (5) Total fee paid:

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[_]  Fee paid previously with preliminary materials.
     
[_]  Check box if any part of the fee is offset as provided by Exchange
     Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.
     
     (1) Amount Previously Paid:
 
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     (2) Form, Schedule or Registration Statement No.:

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Notes:
<PAGE>
 
                         ENERGY BIOSYSTEMS CORPORATION
                           4200 RESEARCH FOREST DRIVE
                           THE WOODLANDS, TEXAS 77381

                           --------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 4, 1997

                           --------------------------

     The Annual Meeting of the Stockholders of Energy BioSystems Corporation, a
Delaware corporation (the "Company"), will be held at the Company's offices,
4200 Research Forest Drive, The Woodlands, Texas 77381 on Wednesday, June 4,
1997 at 10:00 A.M., Central Daylight Saving Time, for the following purposes:

          1.  To elect nine directors to serve until the annual stockholders'
     meeting in 1998 or until their successors have been elected and qualified;

          2.  To approve the Company's 1997 Stock Option Plan;

          3.  To ratify and approve the appointment of Arthur Andersen LLP as
     the Company's independent public accountants for the 1997 fiscal year; and

          4.  To act upon such other business as may properly come before the
     meeting or any adjournments thereof.

     Only stockholders of record at the close of business on April 21, 1997 are
entitled to receive notice of, and to vote at, the meeting.

     IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED AT THE ANNUAL MEETING OF
STOCKHOLDERS REGARDLESS OF THE SIZE OF YOUR HOLDINGS OR WHETHER YOU PLAN TO
ATTEND THE MEETING.  THEREFORE, PLEASE MARK, SIGN, DATE, AND RETURN THE ENCLOSED
PROXY CARD PROMPTLY.  IF YOU ARE PRESENT AT THE MEETING, AND WISH TO DO SO, YOU
MAY REVOKE THE PROXY AND VOTE IN PERSON.

                                    By Order of the Board of Directors


                                    Paul G. Brown, III
                                    Secretary

May 1, 1997
The Woodlands, Texas
<PAGE>
 
                         ENERGY BIOSYSTEMS CORPORATION
                           4200 RESEARCH FOREST DRIVE
                           THE WOODLANDS, TEXAS 77381

                           --------------------------

                                PROXY STATEMENT

                           --------------------------

                              GENERAL INFORMATION

     The accompanying proxy is solicited by the Board of Directors of Energy
BioSystems Corporation (the "Company") for use at the 1997 Annual Meeting of
Stockholders to be held on June 4, 1997 and at any adjournments thereof (the
"Annual Meeting").  The Annual Meeting will be held at 10:00 A.M., Central
Daylight Saving Time, at the Company's principal executive offices, 4200
Research Forest Drive, The Woodlands, Texas.  If the accompanying proxy is
properly executed and returned, the shares it represents will be voted at the
Annual Meeting in accordance with the directions noted thereon or, if no
direction is indicated, it will be voted in favor of the proposals described in
this Proxy Statement.  In addition, the proxy confers discretionary authority to
the persons named in the proxy authorizing those persons to vote, in their
discretion, on any other matters properly presented at the Annual Meeting.  The
Board of Directors is not currently aware of any such other matters.  Any
stockholder giving a proxy has the power to revoke it by oral or written notice
to the Secretary of the Company at any time before it is voted.

     The approximate date on which this Proxy Statement and the accompanying
proxy will first be sent to stockholders is May 1, 1997.

     The number of voting securities of the Company outstanding on April 21,
1997, the record date for the determination of stockholders of the Company
entitled to receive notice of, and to vote at, the Annual Meeting was (i)
11,605,377 shares of common stock, par value $0.01 per share (the "Common
Stock"), each share being entitled to one vote, (ii) 2,000 shares of Series A
Convertible Preferred Stock, par value $0.01 per share (the "Series A Preferred
Stock"), and (ii) 702,100 shares of Series B Convertible Preferred Stock, par
value $0.01 per share (the "Series B Preferred Stock" and, together with the
Series A Preferred Stock, the "Preferred Stock").  Shares of Preferred Stock
have voting rights on all matters subject to a vote of the holders of Common
Stock on an as-converted basis.  As of the record date, the shares of Preferred
Stock are entitled to an aggregate of 4,854,189 votes upon each of the matters
to be voted on at the Annual Meeting.  The total number of votes that may be
cast at the Annual Meeting is 16,459,566.

     The presence, in person or by proxy, of the holders of a majority of the
votes entitled to be cast at the Annual Meeting is required for a quorum.
Abstentions and broker non-votes are counted for purposes of determining whether
a quorum is present.  Holders are not allowed to vote cumulatively.  A plurality
vote is required for the election of directors.  Accordingly, if a quorum is
present at the Annual Meeting, the nine persons receiving the greatest number of
votes will be elected to serve as directors.  Withholding authority to vote for
a director nominee and broker non-votes in the election of directors will not
affect the outcome of the election of directors.  All other matters to be voted
on will be decided by the affirmative vote of a majority of the votes of shares
present or represented at the Annual Meeting and entitled to vote on such
matter.  On any such matter, an abstention will have the same effect as a
negative vote but, because shares held by brokers will not be considered
entitled to vote on matters as to which the brokers withhold authority, a broker
non-vote will have no effect on such vote.
<PAGE>
 
                               PROPOSAL NUMBER 1:

                             ELECTION OF DIRECTORS

     The Board of Directors has nominated and urges you to vote for the election
of the nine nominees identified below who have been nominated to serve as
directors until the next annual meeting of stockholders or until their
successors are duly elected and qualified.  Each of the nominees listed below is
a member of the Company's present Board of Directors.  Proxies solicited hereby
will be voted for all nine nominees unless stockholders specify otherwise in
their proxies.

     If, at the time of or prior to the Annual Meeting, any of the nominees
should be unable or decline to serve, the discretionary authority provided in
the proxy may be used to vote for a substitute or substitutes designated by the
Board of Directors.  The Board of Directors has no reason to believe that any
substitute nominee or nominees will be required.

NOMINEES FOR DIRECTOR

     The nine nominees for election as directors and certain additional
information with respect to each of them, are as follows:
<TABLE>
<CAPTION>
 
                                                                            YEAR FIRST
            NAME               AGE      POSITION WITH THE COMPANY       BECAME A DIRECTOR
            ----               ---      -------------------------       -----------------
<S>                            <C>  <C>                                 <C>
Ramon Lopez..................   63  Chairman of the Board                            1994
John H. Webb.................   47  President, Chief Executive Officer               1991
                                     and Vice Chairman of the Board
R. James Comeaux.............   59               Director                            1997
Edward B. Lurier.............   66               Director                            1991
Thomas E. Messmore, CFA......   51               Director                            1992
Daniel J. Monticello, Ph.D...   41     Director and Vice President,                  1994
                                          Science and Technology
William E. Nasser............   57               Director                            1992
John S. Patton...............   62               Director                            1997
William D. Young.............   52               Director                            1994
 
</TABLE>

     Ramon Lopez.  Mr. Lopez has been a Director since 1994 and Chairman of the
Board of Directors since April 1997.  Mr. Lopez served as Vice President -
Safety, Environment and Technology of Shell Oil Company from October 1992 until
his retirement in October 1993.  He started his career with Shell in 1955 and
held senior responsibilities in all areas of petroleum refining and marketing,
including positions as Vice President of Manufacturing and Technical and General
Manager of the Western and Eastern Regions for Refining and Marketing.  Mr.
Lopez holds a B.S. degree in Chemical Engineering from the University of
Florida.

     John H. Webb.  Mr. Webb joined the Company as its President and Chief
Executive Officer and as a Director in September 1991.  He served as Chairman of
the Board from September 1993 to April 1997, when he became Vice Chairman of the
Board.  Mr. Webb has been in the chemical process industry for more than 20
years.  Mr. Webb was employed by Ethyl Corporation from 1977 to 1991, where he
served in various capacities, including Sales Engineer and Marketing Manager for
the Petroleum Additives Division, Business Director for Lubricant Additives and
Director of Corporate Business Development.  From 1971 to 1977, he was employed
as a Research Chemist and then as the International Sales Coordinator for the
Lubrizol Corporation.  Mr. Webb holds a B.S. degree in Chemistry from Baldwin
Wallace College.

     R. James Comeaux.  Mr. Comeaux has been a Director since April 1997.  Mr.
Comeaux has been President and Chief Executive Officer of Petrochemical
Management Incorporated since 1993.  From 1989 to 1993, Mr. Comeaux served as
President and Chief Executive Officer of Arcadian Corporation.  He served as
Senior Vice President of Fina, 

                                      -2-
<PAGE>
 
Inc. from 1984 to 1989. Prior to joining Fina, Mr. Comeaux spent 17 years at
Gulf Oil Corporation. Mr. Comeaux is a director of Rexene Corporation. Mr.
Comeaux received a B.S. degree in Chemical Engineering from Lamar University.

     Edward B. Lurier.  Mr. Lurier has been a Director since 1991.   Since 1984,
Mr. Lurier has been the Chairman of the Board of Directors of Gryphon Management
Company, Inc. and general partner of Gryphon Financial Partners II, a venture
capital firm which he co-founded.  Gryphon Financial Partners II is the general
partner of Gryphon Ventures II, Limited Partnership, a limited partnership of
which Ethyl Corporation is the sole limited partner.  Mr. Lurier is a director
of IGEN International Inc.

     Thomas E. Messmore, CFA.  Mr. Messmore has been a Director since 1992.
Mr. Messmore has been Managing Director of Zurich Centre Resources, Ltd., a
subsidiary of Zurich Insurance Group, since 1997.  Previously, Mr. Messmore
served as President and Chief Executive Officer of UBS Asset Management (New
York), Inc. from 1995 until October 1996.  Mr. Messmore served as Senior Vice
President of The Travelers Insurance Company from 1984 until his resignation in
January 1994.  Prior thereto, he served as Senior Vice President and Chief
Financial Officer of the Keystone Massachusetts Group, an affiliate of The
Travelers Insurance Company.  Mr. Messmore received a B.S. degree in Engineering
from West Virginia University and an M.B.A. from Harvard Business School.

     Daniel J. Monticello, Ph.D.  Dr. Monticello was the Company's first
employee.  He joined the Company in July 1990 as Vice President, Science and
Technology and became a Director in 1994.  From 1983 to 1990, Dr. Monticello was
employed by Miles Laboratories where he served in various capacities in the
Biotechnology Products Division, including Manager of Biochemistry Research.
Dr. Monticello earned his B.S. degree from the University of Michigan and his
M.S. and Ph.D. in Microbiology from Michigan State University.  His post-
doctoral research at the University of Georgia from 1982 to 1984 concerned the
microbial desulfurization of fossil fuels.

     William E. Nasser.   Mr. Nasser has been a Director since January 1992.
Mr. Nasser is President of Watermill Express, Inc., which he joined in 1997.
Mr. Nasser formerly served as Chairman of the Board and Chief Executive Officer
of Petrolite Corporation from 1992 to 1995 and as President of Petrolite from
1988 to 1992.  He retired in November 1995 after over 30 years of service.  Mr.
Nasser currently is a director of Laclede Gas Company.  He holds a B.S. degree
in Chemical Engineering from the University of Notre Dame and an M.S. degree
from the University of Oklahoma.

     John S. Patton.  Mr. Patton has been a Director since January 1997.  Since
1989, he has been the Director of Investor Relations of Ethyl Corporation.  Mr.
Patton has served in various positions at Ethyl since 1974.  Mr. Patton joined
Sterling Seal Co. in 1957, where he served in various positions until Sterling
Seal was acquired by VCA Corporation in 1972 and Ethyl in 1974.  Mr. Patton
currently is a regional director of Mellon Bank Corporation.

     William D. Young.  Mr. Young has been a Director since 1994.  Mr. Young has
been Chief Operating Officer of Genentech, Inc. since March 1997.  Previously,
Mr. Young was Executive Vice President of Genentech, responsible for Product
Development, Process Sciences, Manufacturing and Quality, Regulatory Affairs,
and Engineering.  Mr. Young serves as a member of the Genentech Operations
Committee and chairs the Product Development Committee. Prior to joining
Genentech in 1980, Mr. Young spent 14 years with Eli Lilly and Company.  He
received his B.S. degree in Chemical Engineering from Purdue University and an
M.B.A. from Indiana University.  Mr. Young is also a Director of GenVec, Inc., a
gene therapy company, and VaxGen, Inc., a company developing HIV vaccines, and
in 1993 was elected to the National Academy of Engineering.

     THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" THE ELECTION
OF EACH OF THE ABOVE-NAMED NOMINEES.

                                      -3-
<PAGE>
 
     All directors hold office until the next annual meeting of the stockholders
of the Company or until their successors have been duly elected and qualified.
The Company's officers are elected annually by, and serve at the pleasure of,
the Board of Directors, subject to the terms of any employment agreements.

     The Company's Certificate of Incorporation and Bylaws provide that the
number of directors on the Board shall be fixed from time to time by the Board
of Directors but shall not be less than three nor more than fifteen persons.
The Board in its discretion and in accordance with such authority has currently
fixed its size at nine members.  No proxy will be voted for a greater number of
persons than the number of nominees named herein.

DIRECTORS' MEETINGS AND COMPENSATION

     During 1996, the Board of Directors met six times and took certain
additional actions by unanimous written consent in lieu of meetings.  During
1996, no director of the Company attended fewer than 75 percent of the meetings
of the Board of Directors.

     Members of the Board of Directors are reimbursed for out-of-pocket expenses
incurred in attending Board of Directors and committee meetings. Messrs. Lopez,
Nasser and Young each receive $1,000 for each board meeting attended.  No other
directors receive fees for their services as a director.

     The Company entered into a consulting agreement in September 1992 with Mr.
Preston, which provides that Mr. Preston will receive approximately $800 for
each day of service or $10,000 for each 12-month term.  The agreement may be
terminated by the Company upon 90 days' prior written notice.

     Under the Company's Non-Employee Director Option Plan, each non-employee
director (except for directors who received options during the preceding year
for more than 4,000 shares of Common Stock under any other plan or agreement and
subject to the right of each eligible non-employee director to decline such
grant) receives an automatic annual grant of non-qualified options to purchase
4,000 shares of Common Stock at an exercise price per share equal to the fair
market value per share of Common Stock on the date the option is granted.

BOARD COMMITTEES

     The Company's Board of Directors has an Audit Committee and a Compensation
Committee.  The Board of Directors does not have a Nominating Committee.  The
Audit Committee's functions include making recommendations concerning the
engagement of independent public accountants, reviewing with the independent
public accountants the plan and results of the auditing engagement, approving
professional services provided by the independent public accountants, and
reviewing the adequacy of the Company's internal accounting controls.  The
current members of the Audit Committee are Messrs. Lopez, Lurier and Messmore.
The Compensation Committee makes recommendations concerning compensation,
including incentive arrangements, for the Company's officers.  The Compensation
Committee also administers the Company's Stock Compensation Plan.  The current
members of the Compensation Committee are Messrs. Lopez, Lurier and Messmore.

     During 1996, the Audit Committee met one time and the Compensation
Committee met two times.  During 1996, no director of the Company attended fewer
than 75 percent of the number of meetings of committees on which he served.

                                      -4-
<PAGE>
 
                             EXECUTIVE COMPENSATION

EXECUTIVE OFFICERS

     Set forth below is certain information concerning the executive officers of
the Company, including the business experience of each during the past five
years.
<TABLE>
<CAPTION>
 
            NAME               AGE           POSITION WITH THE COMPANY
            ----               ---           -------------------------
<S>                            <C>  <C>
John H. Webb.................   47  President, Chief Executive Officer and
                                    Vice Chairman of the Board of Directors
Daniel J. Monticello, Ph.D...   41  Vice President, Science and Technology
Paul G. Brown, III...........   36  Vice President, Finance and Administration
William E. Heck..............   67  Vice President, Engineering
Mark W. John.................   37  Vice President, Sales and Marketing
Jeffrey A. Nagel.............   32  Vice President, Business Development
Michael A. Pacheco, Ph.D.....   40  Vice President, Process Development
</TABLE>

     Information regarding the business experience of Mr. Webb and Dr.
Monticello is set forth above under the heading "Proposal Number 1: Election of
Directors--Nominees for Director."

     Paul G. Brown, III.  Mr. Brown has served as Vice President, Finance and
Administration of the Company since September 1993.  From February 1992 to
September 1993 he served as Corporate Controller of the Company. Mr. Brown spent
10 years with Arthur Andersen & Co. from 1982 to 1992, where he served most
recently as a Tax Manager.  Mr. Brown earned his B.S. degree in Accounting from
the University of New Orleans.

     William E. Heck.  Mr. Heck has served as Vice President, Engineering of the
Company since September 1992. He has over 35 years of experience in petroleum
refinery management and operations.  Mr. Heck spent 17 years with Tenneco Oil
Company from 1972 to 1989, where he served in various executive and supervisory
positions, most recently as Refining Technology Manager.  From 1989 to September
1992, Mr. Heck was employed as the Engineering Manager of Murphy Oil U.S.A.,
Inc.  Mr. Heck earned his B.S. degree in Chemical Engineering from the
University of Houston and completed management programs at the University of
Southern California and Harvard University.

     Mark W. John.  Mr. John joined the Company in December 1991 as Vice
President, Sales and Marketing. Mr. John was with Ethyl Corporation where he
served as Senior Technical Sales Representative from 1987 until he joined the
Company.  Mr. John earned his B.S. degree in Petroleum Geology from the
University of Wyoming.

     Jeffrey A. Nagel.    Mr. Nagel joined the Company in January 1992 as
Director of Marketing and was promoted to Vice President, Business Development
in October 1996.  Prior to joining the Company, Mr. Nagel specialized in new
business development and turnarounds for Cannon Associates.  He received a B.S.
in Mechanical Engineering from Carnegie-Mellon University and completed his
M.B.A. at Carnegie-Mellon's Graduate School of Industrial Administration.

     Michael A. Pacheco, Ph.D.  Dr. Pacheco has served as Vice President,
Process Development of the Company since April 1997.  From 1984 to 1997, Dr.
Pacheco held a variety of positions in the Refining Business Group of Amoco
Corporation.  He is a registered professional engineer in the State of
California.  Dr. Pacheco received his B.S. in Chemical Engineering from Clarkson
University and his Ph.D. in Chemical Engineering from the University of
California at Berkeley.

                                      -5-
<PAGE>
 
REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

     The Compensation Committee (the "Committee") of the Board of Directors of
the Company currently consists of Ramon Lopez, Edward B. Lurier and Thomas E.
Messmore, none of whom are officers or employees of the Company.  The Committee
is responsible for evaluating the performance of management, determining the
compensation for certain executive officers of the Company and administering the
Company's Stock Compensation Plan under which grants may be made to employees of
the Company.  The Committee has furnished the following report on executive
compensation for 1996:

     Under the supervision of the Committee, the Company has developed a
compensation policy which is designated to attract and retain key executives
responsible for the success of the Company and motivate management to enhance
long-term stockholder value.  The annual compensation package for executive
officers primarily consists of (i) a cash salary which reflects the
responsibilities relating to the position and individual performance, (ii)
variable performance awards payable in cash or stock and tied to the
individual's or the Company's achievement of certain goals or milestones and
(iii) long-term stock based incentive awards which strengthen the mutuality of
interests between the executive officers and the Company's stockholders.

     In determining the level and composition of compensation of each of the
Company's executive officers, the Committee takes into account various
qualitative and quantitative indicators of corporate and individual performance.
Although no specific target has been established, the Committee generally seeks
to set salaries at the median to high end of the range in comparison to peer
group companies.  In setting such salaries, the Committee considers its peer
group to be certain companies in the biotechnology and environmental industries
with market capitalizations similar to that of the Company.  Such competitive
group does not necessarily include the companies comprising the "Standard &
Poor's Pollution Control Index" (the "SPPCI") reflected in the performance graph
in this Proxy Statement, which is the industry categorization the Company has
been placed in by its investment bankers.  Because the Company is still in the
development stage, the use of certain traditional performance standards (e.g.,
profitability and return on equity) is not currently appropriate in evaluating
the performance of the Company's executive officers.  Consequently, in
evaluating the performance of management the Committee takes into consideration
such factors as the Company's achieving specified milestones or goals under
various research or development programs.  In addition, the Committee recognizes
performance and achievements that are more difficult to quantify, such as the
successful supervision of major corporate projects, demonstrated leadership
ability, and contributions to the industry and community development.  For 1996,
the Committee included in its evaluation the significant progress made by the
Company, including the continuing advancement of the Company's research
development under existing research and collaboration agreements.

     Base compensation is established through negotiation between the Company
and the executive officer at the time the executive is hired, and then
subsequently adjusted when such officer's base compensation is subject to review
or reconsideration.  While the Company has entered into employment agreements
with certain of its executive officers, such agreements provide that base
salaries after the initial year will be determined by the Committee after
review.  When establishing or reviewing base compensation levels for each
executive officer, the Committee, in accordance with its general compensation
policy, considers numerous factors, including the responsibilities relating to
the position, the qualifications of the executive and the relevant experience
the individual brings to the Company, strategic goals for which the executive
has responsibility, and compensation levels of companies at a comparable stage
of development who compete with the Company for business, scientific, and
executive talents.  As stated above, such comparable companies are generally
those with similar market capitalizations and are not necessarily among the
companies comprising the SPPCI reflected in the performance graph in this Proxy
Statement.  No pre-determined weights are given to any one of such factors.  In
addition, in 1994 and 1995 the Company hired an independent compensation
consultant to advise the Committee on general compensation matters and to
prepare a report for the Committee with respect to the Company's compensation
policy.  Base salaries for each of the executive officers other than the Chief
Executive Officer, as discussed below, were increased in 1996 following the
Committee's review of recommendations made by the Chief Executive Officer and
based on the consultant's report.  The base salaries for the executive officers
generally, and the Chief Executive Officer specifically, for fiscal 1996 were at
the median level in comparison to the Company's peer group companies.

                                      -6-
<PAGE>
 
     In addition to each executive officer's base compensation, the Committee
may award cash bonuses and/or grant awards under the Company's Stock
Compensation Plan to chosen executive officers depending on the extent to which
certain defined personal and corporate performance goals are achieved.  Such
corporate performance goals are the same as discussed above.  Because the
Company's technology is still in the early stages of development, the Company
has granted minimal bonuses to its executive officers.  No bonuses were awarded
to the Company's executive officers in 1996.

     All employees of the Company, including its executive officers, are
eligible to receive long-term stock based incentive awards under the Company's
Stock Compensation Plan as a means of providing such individuals with a
continuing proprietary interest in the Company.  Such grants further the
mutuality of interest between the Company's employees and its stockholders by
providing significant incentives for such employees to achieve and maintain high
levels of performance.  The Company's Stock Compensation Plan enhances the
Company's ability to attract and retain the services of qualified individuals.
Factors considered in determining whether such awards are granted to an
executive officer of the Company include the executive's position in the
Company, his or her performance and responsibilities, the amount of restricted
stock options, if any, currently held by the officer, the vesting schedules of
any such options or restricted stock and the executive officer's other
compensation.  While the Committee does not adhere to any firmly established
formulas or schedules for the issuance of awards such as options or restricted
stock, the Committee will generally tailor the terms of any such grant to
achieve its goal as a long-term incentive award by providing for a vesting
schedule encompassing several years or tying the vesting dates to particular
corporate or personal milestones.  For example, Dr. Monticello,  Mr. Brown and
Mr. John were granted options to acquire an aggregate of 40,000 shares of Common
Stock in 1996 in recognition of their continuing contributions to the Company,
with vesting contingent on the Company accomplishing specific goals (see "Option
Grants in Last Fiscal Year" in this Proxy Statement).

     The annual base salary of John H. Webb, the President and Chief Executive
Officer of the Company, was initially set at $175,000 pursuant to an employment
agreement effective September 16, 1991 and was increased by $12,500 (or
approximately 7.1 percent) to $187,500 in January 1993 to keep pace with
salaries being paid to other chief executive officers of similar companies and
in recognition of the Company's progress in 1992.  In January 1994 the Committee
increased Mr. Webb's base salary by $37,500 (or approximately 20 percent) to
$225,000.  Mr. Webb was not granted any options or awarded any bonus in 1996.

     Section 162(m) of the Internal Revenue Code of 1986, as amended (the
"Code"), added by the Revenue Reconciliation Act of 1993, places a $1 million
cap per executive on the deductible compensation that can be paid to certain
executives of publicly-traded corporations.  Amounts that qualify as
"performance based" compensation under Section 162(m)(4)(c) of the Code are
exempt from the cap and do not count toward the $1 million limit.  Generally,
stock options will qualify as performance based compensation.  The Committee has
discussed and considered and will continue to evaluate the potential impact of
Section 162(m) on the Company in making compensation determinations, but has not
established a set policy with respect to future compensation determinations.

     The foregoing report is given by the following members of the Compensation
Committee:

                                  Ramon Lopez
                                Edward B. Lurier
                               Thomas E. Messmore

     The report of the Compensation Committee shall not be deemed incorporated
by reference by any general statement incorporating by reference this Proxy
Statement into any filing under the Securities Act of 1933, as amended, or under
the Securities Exchange Act of 1934, as amended, except to the extent that the
Company specifically incorporates this information by reference, and shall not
otherwise be deemed filed under such acts.

                                      -7-
<PAGE>
 
EXECUTIVE COMPENSATION

     The following table summarizes certain information regarding aggregate cash
compensation, stock option and restricted stock awards and other compensation
earned by the Company's Chief Executive Officer and each of the four other most
highly compensated executive officers of the Company during the last three
years.
<TABLE>
<CAPTION>
 
                                                                       LONG-TERM
                                                                  COMPENSATION AWARDS
                                                                  --------------------
                                                                                 SECURITIES       
                                     ANNUAL COMPENSATION        RESTRICTED       UNDERLYING       
                                     -------------------          STOCK           OPTIONS          ALL OTHER  
NAME AND PRINCIPAL POSITION  YEAR    SALARY          BONUS        AWARDS          (NUMBER)        COMPENSATION
- - ---------------------------  ----    --------        -----      ----------      ------------      ------------ 
<S>                          <C>     <C>            <C>         <C>             <C>             <C>
John H. Webb................ 1996    $225,000        $  --      $      --               --         $21,592/(1)/        
  President, Chief           1995     225,000          709             --           70,000          16,000/(2)/  
   Executive Officer and     1994     217,266          709             --           36,900          21,037/(3)/  
   Vice Chairman             
                             
Daniel J. Monticello, Ph.D.. 1996    $161,000        $  --      $      --           13,000         $13,673/(1)/        
  Vice President, Science    1995     153,117          709         15,625/(4)/      15,000          13,248/(2)/             
   and Technology            1994     143,100          709             --           13,000          11,448/(3)/             
                                                                                                                              
Paul G. Brown, III.......... 1996    $124,203        $  --      $      --           15,000         $ 9,936/(1)/        
  Vice President,            1995     117,553          709             --           14,000           9,404/(2)/             
   Finance and               1994     109,209          709             --           12,000           8,680/(3)/  
    Administration           

Mark W. John................ 1996    $127,000        $  --      $      --           12,000         $10,160/(1)/        
  Vice President, Sales and  1995     122,250          810         12,500/(4)/      14,000           9,780/(2)/             
  Marketing                  1994     116,250          709             --           12,000           9,300/(3)/             
                                                                                                                              
Robert E. Levy, Ph.D/(5)/... 1996    $142,000        $  --      $      --           10,000         $11,360/(1)/       
  Vice President,            1995     136,470          709         12,500/(4)/          --           9,780/(2)/             
  Government and             1994     128,963          509             --           12,000           8,051/(3)/              
  Regulatory Affairs
 
</TABLE>
- - ------------------------

/(1)/ Represents Company contributions to the Company's Simplified Employee
      Pension Plan ("SEP"). During the year ended December 31, 1996, perquisites
      for each individual named in the Summary Compensation Table aggregated
      less than 10% of the total annual salary and bonus reported for such
      individual in the Summary Compensation Table. Accordingly, no such amounts
      are included in the Summary Compensation Table.
/(2)/ Represents Company contributions to the SEP. During the year ended
      December 31, 1995, perquisites for each individual named in the Summary
      Compensation Table aggregated less than 10% of the total annual salary and
      bonus reported for such individual in the Summary Compensation Table.
      Accordingly, no such amounts are included in the Summary Compensation
      Table.
/(3)/ Represents Company contributions to the SEP. During the year ended
      December 31, 1994, perquisites for each individual named in the Summary
      Compensation Table aggregated less than 10% of the total annual salary and
      bonus reported for such individual in the Summary Compensation Table.
      Accordingly, no such amounts are included in the Summary Compensation
      Table.
/(4)/ Messrs. Monticello, Brown, John and Levy were granted 2,500, 1,500, 2,000
      and 2,000 shares of restricted stock, respectively, on January 3, 1995,
      under the Company's Stock Compensation Plan. All of such shares vested on
      June 3, 1995. The restricted stock value shown in the table is based upon
      the closing price of the Common Stock on The Nasdaq Stock Market on the
      date of grant.
/(5)/ Dr. Levy resigned as an officer of the Company effective March 31, 1997.

                                      -8-
<PAGE>
 
STOCK OPTIONS

     The following table sets forth information concerning the grant of stock
options under the Company's Stock Compensation Plan during 1996 to the executive
officers named in the Summary Compensation Table.

                       OPTION GRANTS IN LAST FISCAL YEAR
<TABLE>
<CAPTION>
 
                             INDIVIDUAL GRANTS
- - -------------------------------------------------------------------------- 
                                             PERCENTAGE                                                        
                               NUMBER        OF TOTAL                             POTENTIAL REALIZABLE VALUE   
                               OF            OPTIONS                               AT ASSUMED ANNUAL RATES     
                               SECURITIES    GRANTED TO                           OF STOCK PRICE APPRECIATION  
                               UNDERLYING    EMPLOYEES     EXERCISE                   FOR OPTION TERM/(2)/     
                               OPTIONS       IN            PRICE PER  EXPIRATION  ----------------------------    
       NAME                    GRANTED/(1)/  FISCAL 1996     SHARE       DATE               5%            10%  
       ----                    ------------  -----------   ---------  ----------           ---           ----
<S>                            <C>           <C>           <C>        <C>         <C>             <C>
John H. Webb                             --           --          --          --              --            --
Daniel J. Monticello, Ph.D.          13,000          5.2%      $6.50      3/5/06         $53,170      $134,680
Paul G. Brown, III                   15,000          6.0%       6.50      3/5/06          61,350       155,400
Mark W. John                         12,000          4.8%       6.50      3/5/06          49,080       124,320
Robert E. Levy, Ph.D.                10,000          4.0%       6.50      3/5/06          40,900       103,600
 
</TABLE>

/(1)/ No stock appreciation rights ("SARs") or other instruments were granted in
      tandem with the options reflected in this table.
/(2)/ The Securities and Exchange Commission requires disclosure of the
      potential realizable value or present value of each grant. The disclosure
      assumes the options will be held for the full ten-year term prior to
      exercise. Such options may be exercised prior to the end of such ten-year
      term. The actual value, if any, an executive officer may realize will
      depend upon the excess of the stock price over the exercise price on the
      date the option is exercised. There is no assurance that the stock price
      will appreciate at the rates shown in the table. If the assumed annual
      rate of stock price appreciation of 5% or 10% per year should occur, the
      market value per share of Common Stock at the end of the ten-year option
      term would be $10.59 and $16.86, respectively.

OPTION EXERCISES AND HOLDINGS

     The following table sets forth information concerning option exercises and
the value of unexercised options held by the executive officers of the Company
named in the Summary Compensation Table.

                      AGGREGATED OPTION EXERCISES IN 1996
                     AND OPTION VALUES AT DECEMBER 31, 1996
<TABLE>
<CAPTION>
                                                             NUMBER OF SECURITIES       VALUE OF UNEXERCISED
                                                            UNDERLYING UNEXERCISED         IN-THE-MONEY
                                                                OPTIONS HELD AT           OPTIONS HELD AT
                                  SHARES                     DECEMBER 31, 1996 (#)      DECEMBER 31, 1996/(1)/ ($)
                               ACQUIRED ON      VALUE      ------------------------     ---------------------------
       NAME                    EXERCISE (#)  REALIZED ($)  EXERCISE   UNEXERCISABLE     EXERCISABLE   UNEXERCISABLE
      ------                   ------------  ------------  --------   -------------     -----------   -------------
<S>                            <C>           <C>           <C>        <C>               <C>           <C>
John H. Webb................            --            --   237,310          269,430        $928,547         712,320
Daniel J. Monticello, Ph.D..            --            --   205,440           37,080         944,864           6,563         
Paul G. Brown, III..........            --            --    27,876           43,644           3,166          13,529         
Mark W. John................         7,000        23,118    63,130           74,584         241,216         227,724         
Robert E. Levy, Ph.D........            --            --    19,150           43,350           5,250           5,250
</TABLE>
- - ------------------------

/(1)/ Computed based on the difference between aggregate fair market value and
      aggregate exercise price.  The fair market value of the Company's Common
      Stock on December 31, 1996, was $6.00 based on the average of the high and
      low prices on the Nasdaq Market on December 31, 1996.

                                      -9-
<PAGE>
 
SIMPLIFIED EMPLOYEE PENSION PLAN

     In April 1992, the Company adopted a Simplified Employee Pension Plan (the
"SEP") for all employees. Under the terms of the SEP, employees are eligible to
participate after completion of six months of service.  The Company has the
discretion to determine how much, if anything, it will contribute to the
employee's accounts in the SEP each year.  Currently, the Company contributes an
amount equal to eight percent of the employees' monthly compensation to the SEP.
Employees are vested immediately and there is at present no employee
contribution.  Total expense under the SEP was approximately $301,682 for the
year ended December 31, 1996.

PERFORMANCE GRAPH

     The following performance graph compares the performance of the Company's
Common Stock to the Nasdaq Combined Composite Index and Standard & Poor's
Pollution Control Index for the period beginning March 12, 1993 and ending
December 31, 1996.  The graph assumes that the value of the investment in the
Company's Common Stock and each index was $100 at January 1, 1994, and that all
dividends were reinvested.

                        COMPARISON OF CUMULATIVE RETURN
                      AMONG ENERGY BIOSYSTEMS CORPORATION,
                      NASDAQ COMBINED COMPOSITE INDEX AND
                   STANDARD & POOR'S POLLUTION CONTROL INDEX



                             [GRAPH APPEARS HERE]


<TABLE>
<CAPTION>
 
- - --------------------------------------------------------------------------------------------

                                             3/12/93  12/31/93  12/30/94  12/29/95  12/31/96

- - --------------------------------------------------------------------------------------------
<S>                                          <C>      <C>       <C>       <C>       <C>
Energy BioSystems Corporation                    100    170.37     92.59    103.70     88.89
- - --------------------------------------------------------------------------------------------
Nasdaq Combined Composite Index                  100    112.56    108.96    152.46    187.07
- - --------------------------------------------------------------------------------------------
Standard & Poor's Pollution Control Index        100     81.28     82.32     92.02     96.09
- - --------------------------------------------------------------------------------------------
</TABLE>

     The foregoing stock price performance comparisons shall not be deemed
incorporated by reference by any general statement incorporating by reference
this Proxy Statement into any filing under the Securities Act of 1933, as
amended, or under the Securities Exchange Act of 1934, as amended, except to the
extent that the Company specifically incorporates such comparisons by reference,
and shall not otherwise be deemed filed under such acts.

                                      -10-
<PAGE>
 
     There can be no assurance that the Company's stock performance will
continue into the future with the same or similar trends depicted in the graph
above.  The Company will not make or endorse any predictions as to future stock
performance.

EMPLOYMENT AGREEMENTS

     In August 1991, Mr. John H. Webb entered into a five-year employment
agreement with the Company effective September 16, 1991 providing for Mr. Webb
to serve as President for an initial annual salary of $175,000, which is to be
reviewed no less than annually by the Board of Directors.  The agreement was
extended in January 1996 through January 2001.  The agreement also provides that
Mr. Webb will serve as a director of the Company if the Company so requests.  If
Mr. Webb is terminated without cause, as that term is defined in the agreement,
the Company is obligated to pay Mr. Webb an amount not greater than one year of
his salary at the time of termination.  Mr. Webb's current annual salary is
$225,000.

     In January 1996, the Company entered into an employment agreement with Dr.
Daniel J. Monticello providing for an initial annual salary of $161,000, which
is to be reviewed no less than annually by the Board of Directors.  The
agreement expires in April 1999.  If Dr. Monticello is terminated without cause,
as that term is defined in the agreement, the Company is obligated to pay Dr.
Monticello an amount not greater than one year of his salary at the time of
termination.  Dr. Monticello's current annual salary is $161,000.

     In July 1995, Messrs. Brown and John entered into five-year employment
agreements with the Company providing for initial annual salaries of $119,840,
and $121,000, respectively, which are to be reviewed no less than annually by
the Board of Directors.  If either of these individuals is terminated without
cause, as that term is defined in the agreement, the Company is obligated to pay
such individual an amount not greater than six months of his salary at the time
of termination.  Messrs. Brown and John's current annual salaries are $126,000
and $127,000, respectively.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The Compensation Committee of the Board of Directors of the Company
currently consists of Messrs. Lopez, Lurier and Messmore.  No member of the
Compensation Committee of the Board of Directors of the Company was, during
1996, an officer or employee of the Company, or was formerly an officer of the
Company or had any relationships requiring disclosure by the Company under Item
404 of Regulation S-K.

     During fiscal 1996, no executive officer of the Company served as (i) a
member of the compensation committee (or other board committee performing
equivalent functions) of another entity, one of whose executive officers served
on the Compensation Committee of the Board of Directors, (ii) a director of
another entity, one of whose executive officers served on the Compensation
Committee of the Board of Directors of the Company or (iii) a member of the
compensation committee (or other board committee performing equivalent
functions) of another entity, one of whose executive officers served as a
director of the Company.

CERTAIN TRANSACTIONS

     In January 1996, the Company extended Mr. Webb's employment agreement
through January 2001 and entered into a new employment agreement with Dr.
Monticello that expires in April 1999.  See "--Employment Agreements."

                                      -11-
<PAGE>
 
                               PROPOSAL NUMBER 2:

                       APPROVAL OF 1997 STOCK OPTION PLAN

     The Company uses stock-based awards as a part of its overall compensation
program in order to align the long-term interests of its employees with those of
its stockholders.  On January 14, 1997, the Board of Directors adopted the
Company's 1997 Stock Option Plan (the "Plan").  Under the Plan, key employees
and consultants are eligible to receive grants of Options, which are defined and
described more fully below.

     Stockholder approval is required for grants of Options under the Plan to be
exempt from a cap on the tax deductibility of the grants of Options by the
Company imposed by Section 162(m) of the Internal Revenue Code of 1986, as
amended (the "Code").  Section 162(m) of the Code, added by the Revenue
Reconciliation Act of 1993, as amended, places a $1 million cap on the
deductible compensation that can be paid to certain executives of publicly
traded corporations.  Amounts that qualify as "performance based" compensation
under Section 162(m)(4)(c) of the Code are exempt from the cap and do not count
toward the $1 million limit.

     The terms of the Plan are summarized below.  In addition, the full text of
the Plan is set forth in Appendix A to this Proxy Statement.  The following
summary is qualified in its entirety by reference to the text of the Plan.

SUMMARY OF THE PLAN

     Purpose.  The purpose of the Plan is to attract and retain the best
available personnel for positions of substantial responsibility, to provide
additional incentive to employees and consultants of the Company and to promote
the success of the Company's business.

     Effective Date of Plan.  The Plan is effective as of January 14, 1997.  No
Option shall be granted pursuant to the Plan after January 14, 2007.

     Eligibility.  The individuals who shall be eligible to receive Incentive
Options and Nonqualified Options (together, the "Options") shall be those key
employees and consultants of the Company as the Compensation Committee of the
Board of Directors or such other committee that the Board of Directors may
designate to administer the Plan (the "Committee") shall determine from time to
time.  "Incentive Option" means an Option granted under the Plan which is
designated as an "Incentive Option" and satisfies the requirements of Section
422 of the Code.  "Nonqualified Option" means an Option granted under the Plan
other than an Incentive Option.

     Administration.  The Plan provides that the Committee shall be constituted
in such a manner as to permit the Plan to comply with Rule 16b-3  ("Rule 16b-3")
promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange
Act") with respect to a plan intended to qualify thereunder as a discretionary
plan.  All questions of interpretation and application of the Plan and Options
shall be subject to the determination of the Committee.  The Plan shall be
administered in such a manner as to permit the Options granted under it which
are designated to be Incentive Options to qualify as Incentive Options.    To
comply with Section 162(m) of the Code, it is the Company's intent that the
Committee shall be constituted solely of two or more Directors who are "outside
directors" within the meaning of the Treasury Regulations promulgated under
Section 162(m) of the Code.  The Committee has complete authority to construe,
interpret and administer provisions of the Plan, to determine which persons are
to be granted Options, the terms and conditions of Options, and to make all
other determinations necessary or deemed advisable in the administration of the
Plan.

     Reserved Shares.  The total number of shares of Common Stock with respect
to which Options may be granted under the Plan shall be 100,000 shares, subject
to adjustment as provided in the Plan.  The shares may be treasury shares or
authorized but unissued shares.  The maximum number of shares subject to Options
which may be issued to any person who is granted an Option under the Plan
("Optionee") during any period of three consecutive years is 100,000 shares.

                                      -12-
<PAGE>
 
     Terms of Options.  The price at which Common Stock may be purchased under
an Option shall be established by the Committee, provided that the price at
which Common Stock may be purchased under an Option that is intended to qualify
as an Incentive Option shall not be less than 100 percent of the fair market
value of the Common Stock on the date the Incentive Option is granted.  In the
case of any 10 percent holder of Common Stock, the price at which shares of
Common Stock may be purchased under an Incentive Option shall not be less than
110 percent of the fair market value of the Common Stock on the date the
Incentive Option is granted. The expiration date of an Option shall be
established by the Committee, provided that no Incentive Option shall be
exercisable after the expiration of 10 years from the date the Incentive Option
is granted.  In the case of a 10 percent holder of Common Stock, no Incentive
Option shall be exercisable after the expiration of five years from the date the
Incentive Option is granted.  To the extent that the aggregate fair market value
(determined as of the time an Incentive Option is granted) of the Common Stock
with respect to which Incentive Options first become exercisable by the Optionee
during any calendar year (under the Plan and any other incentive stock option
plan(s) of the Company or any affiliate) exceeds $100,000, the Incentive Options
shall be treated as Nonqualified Options.  In making this determination,
Incentive Options shall be taken into account in the order in which they were
granted.

     Exercise of Options.  Each Option may be exercised from time to time, in
whole or in part, in the manner and subject to the conditions the Committee, in
its sole discretion, may provide in the written option agreement, as long as the
Option is valid and outstanding. The consideration to be paid for the shares to
be issued upon exercise of an Option, including the method of payment, shall be
determined by the Committee and may consist entirely of (i) cash, (ii) a
promissory note or notes, (iii) other shares of the Company's capital stock,
(iv) authorization for the Company to retain from the total number of shares as
to which the Option is exercised that number of shares having a fair market
value on the date of exercise equal to the exercise price for the total number
of shares as to which the Option is exercised, (v) delivery of a properly
executed exercise notice together with irrevocable instructions to a broker to
promptly deliver to the Company the amount of sale or loan proceeds required to
pay the exercise price or (vi) any combination of the foregoing methods of
payment.  The Committee will determine the period over which individual Options
become exercisable.

     Non-Transferability and No Rights as Stockholder.  Options shall not be
transferable by the Optionee otherwise than by will or under the laws of descent
and distribution, and shall be exercisable, during the Optionee's lifetime, only
by him.  No Optionee shall have any rights as a stockholder with respect to
Common Stock covered by his Option until the date a stock certificate is issued
for the Common Stock.

     Changes in the Company's Capital Structure. If the Company shall effect a
subdivision or consolidation of shares or other capital readjustment, the
payment of a stock dividend, or other increase or reduction of the number of
shares of the Common Stock outstanding, without receiving compensation therefor
in money, services or property, then (i) the number, class, and per share price
of shares of Common Stock subject to outstanding Options shall be appropriately
adjusted in such a manner as to entitle an Optionee to receive upon exercise of
an Option, for the same aggregate cash consideration, the same total number and
class of shares as he would have received had he exercised his Option in full
immediately prior to the event requiring the adjustment; and (ii) the number and
class of shares of Common Stock then reserved for issuance under the Plan shall
be adjusted by substituting for the total number and class of shares of Common
Stock then reserved that number and class of shares of stock that would have
been received by the owner of an equal number of outstanding shares of each
class of Common Stock as the result of the event requiring the adjustment.

     If the Company shall be a party to a merger or a similar reorganization
after which the Company is not the surviving corporation, or if there is a sale
of all or substantially all the Common Stock or a sale of all or substantially
all of the assets of the Company, or if the Company is to be liquidated or
dissolved (any of which events shall constitute a "Significant Transaction"),
then, subject to the provisions hereof, the Committee, in its discretion, may
accelerate the vesting of all outstanding Options or take such other action with
respect to outstanding Options as it deems appropriate, including, without
limitation, canceling such outstanding Options and paying the Optionees an
amount equal to the value of such Options, as determined by the Board.

                                      -13-
<PAGE>
 
     Notwithstanding the foregoing, if a Significant Transaction shall occur in
connection with or following a Change in Control (as defined in the Plan), in
connection with which Significant Transaction the holder of any Option that is
not fully vested shall not receive, in respect of such Option, a substitute
award of stock options containing substantially similar terms to and having an
equal or greater fair market value than such Option, then the Committee shall
either (i) accelerate the vesting of such Option within a reasonable time prior
to the completion of such Significant Transaction (such that the holder of such
Option would have the opportunity to participate in the Significant Transaction
on the same basis as holders of Common Stock, subject to such holder's exercise
of such Option) or (ii) cancel such Option in consideration of the payment to
the holder thereof of an amount (in cash) equal to the fair market value of such
Option.  For purposes of the foregoing, the fair market value attributable to
Options shall be determined by the Committee either, at its election, (x) in
accordance with the Black-Scholes method (for purposes of which volatility shall
be measured over the preceding one year period and the risk-free interest rate
shall be the rate of U.S. treasury bills with a maturity corresponding to the
remaining term of such Option) or (y) to be an amount equal to the fair market
value of the Common Stock subject to such Option less the exercise price thereof
and (ii) the fair market value of (A) any Options shall be determined as of the
date, either of the Change in Control or of the Significant Transaction, that
results in the greater fair market value of such Options, and (B) any substitute
award shall be determined as of the date of the Significant Transaction.

     Amendment or Termination of the Plan.  The Board of Directors of the
Company may amend, terminate or suspend the Plan at any time, in its sole and
absolute discretion; provided, however, that to the extent required to maintain
the status of any Incentive Option under the Code, no amendment that would (i)
change the aggregate number of shares of Common Stock which may be issued under
Incentive Options, (ii) change the class of employees eligible to receive
Incentive Options, or (iii) decrease the exercise price for Incentive Options
below the fair market value of the Common Stock at the time it is granted, shall
be made without the approval of the Company's stockholders.

FEDERAL INCOME TAX CONSEQUENCES OF THE PLAN

     Incentive Options.  An employee who has been granted an Incentive Option
will not realize taxable income at the time of the grant or exercise (but in
some circumstances may be subject to an alternative minimum tax as a result of
the exercise) of such Option and the Company will not be entitled to a deduction
at either such time.  If the employee makes no disposition of the shares
acquired pursuant to an incentive Option within two years from the date of the
grant of such option, or within one year of the transfer of such shares to him
or her, any gain or loss realized on a subsequent disposition of such shares
will be treated as a long-term capital gain or loss.  Under such circumstances,
the Company will not be entitled to any deduction for federal income tax
purposes.  If the foregoing holding period requirements are not satisfied, a
portion of any gain in the year of disposition will be taxable to the employee
as ordinary income, and the Company will be entitled to a corresponding
deduction.  The Company will not be entitled to any deduction in connection with
any loss to the employee or the portion of any gain that is taxable to the
employee as short-term or long-term capital gain.

     Nonqualified Options.  Nonqualified Options will not qualify for special
federal income tax treatment.  No tax is imposed on the optionee upon the grant
of a Nonqualified Option.  Upon exercise of a Nonqualified Option, the employee
will realize ordinary income in an amount measured by the excess, if any, of the
fair market value of the shares on the date of exercise over the Option exercise
price, and the Company will be entitled to a corresponding deduction, provided
the Company withholds income tax with respect to such amount and provided that
such amount is not limited by Section 162(m) of the Code with respect to Options
with an exercise price that was less than the fair market value of the Common
Stock on the date of grant.  However, if the shares received upon the exercise
of a Nonqualified Option are transferred to the Optionee subject to certain
restrictions, then the taxable income realized by the Optionee, unless the
Optionee elects otherwise, and the Company's tax deduction (assuming any federal
income tax withholding requirements are satisfied) should be deferred and should
be measured based upon the fair market value of the shares at the time the
restrictions lapse.  The restrictions imposed on officers, directors and 10
percent stockholders by Section 16(b) of the Securities Exchange Act of 1934, as
amended, is such a restriction during the period prescribed thereby if other
shares have been purchased by such individual within six months of the exercise
of a Nonqualified Option.  Ordinary income realized upon the exercise of a
Nonqualified Option is not an adjustment for alternative minimum tax purposes.

                                      -14-
<PAGE>
 
     Tax Withholding.  The Company shall be entitled to deduct from other
compensation payable to each Optionee any sums required by federal law to be
withheld with respect to the grant or exercise of an Option.  In the
alternative, the Company may require the Optionee to pay the sum to the Company.
The Plan also permits the Committee, in its discretion, to permit the Optionee
to satisfy the withholding tax obligation by electing to have the Company
withhold from the shares to be issued on exercise that number of shares having a
fair market value equal to the amount required to be withheld.

     THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE "FOR" APPROVAL
OF THE COMPANY'S 1997 STOCK OPTION PLAN, AND PROXIES EXECUTED AND RETURNED WILL
BE SO VOTED UNLESS CONTRARY INSTRUCTIONS ARE INDICATED THEREON.

                               PROPOSAL NUMBER 3:

                   APPROVAL OF INDEPENDENT PUBLIC ACCOUNTANTS

     The Board of Directors has appointed the firm of Arthur Andersen LLP as the
Company's independent public accountants to make an examination of the accounts
of the Company for the fiscal year ending December 31, 1997, subject to
ratification by the Company's stockholders.  Representatives of Arthur Andersen
LLP will be present at the Annual Meeting and will have an opportunity to make a
statement, if they desire to do so.  They will also be available to respond to
appropriate questions from stockholders attending the Annual Meeting.

     THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" RATIFICATION
OF ARTHUR ANDERSEN LLP'S APPOINTMENT, AND PROXIES EXECUTED AND RETURNED WILL BE
SO VOTED UNLESS CONTRARY INSTRUCTIONS ARE INDICATED THEREON.

                                      -15-
<PAGE>
 
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The following table sets forth, as of March 31, 1997, certain information
with respect to the shares of Common Stock and Series B Preferred Stock
beneficially owned by (i) each person known by the Company to be the beneficial
owner of more than five percent of the Common Stock or the Series B Preferred
Stock, (ii) each director of the Company, (iii) each of the executive officers
of the Company and (iv) all directors and executive officers of the Company as a
group.
<TABLE>
<CAPTION>
 
                                                                             AMOUNT AND NATURE             
                                            AMOUNT AND NATURE                  OF BENEFICIAL               
                                              OF BENEFICIAL                     OWNERSHIP OF      PERCENT  
                                              OWNERSHIP OF     PERCENT OF         SERIES B           OF    
         NAME OF BENEFICIAL OWNER           COMMON STOCK/(1)/     CLASS     PREFERRED STOCK/(1)/   CLASS  
- - ------------------------------------------  -----------------  -----------  --------------------  -------- 
<S>                                         <C>                <C>          <C>                   <C>
Gryphon Ventures II, Limited Partnership..  2,136,078             18.4%                  --           --  
  222 Berkeley Street, Suite 1600                                                                          
  Boston, Massachusetts  02116                                                                             
Zesiger Capital Group LLC.................  1,857,056/(2)/        14.6%             160,300         22.8%  
  320 Park Avenue, 30th Floor                                                                              
  New York, New York 10022                                                                                 
Ethyl Corporation.........................  1,319,316/(3)/        10.4%             160,000         22.8%  
   300 South Fourth Street                                                                                 
   Richmond, Virginia  23217                                                                               
State of Wisconsin Investment Board.......    942,500              8.1%                  --           --  
  121 E. Wilson Street, 2nd Floor                                                                          
Madison, Wisconsin 53702                                                                                   
Keystone, Inc.............................    732,862/(4)/         6.2%              40,000          5.7%  
  200 Crescent Court, Suite 500                                                                            
  Dallas, Texas 75201                                                                                      
General Motors Employees                                                                                   
   Domestic Group Trust...................    689,655/(5)/         5.6%             100,000         14.2%  
   c/o Pecks Management                                                                                    
   One Rockefeller Plaza                                                                                   
   New York, New York 10020                                                                                
Farmers Insurance Group of Companies......    579,066/(6)/         4.7%              80,000         11.4%  
  4680 Wilshire Boulevard                                                                                  
  Los Angeles, California  90010                                                                           
 Froley Revy Investment Co., Inc..........    275,862/(7)/         2.3%              40,000          5.7%  
   1900 Wilshire Boulevard, Suite 1050                                                                     
   Los Angeles, California 90024                                                                           
John H. Webb..............................    237,310/(8)/         2.0%                  --           --  
Ramon Lopez...............................     23,000/(9)/           *                   --           --  
R. James Comeaux..........................     25,000                *                   --           --  
Edward B. Lurier..........................  2,142,078/(10)/       18.4%                  --           --  
Thomas E. Messmore........................     25,000/(11)/          *                   --           --  
Daniel J. Monticello, Ph.D................    207,990/(12)/        1.8%                  --           --  
William E. Nasser.........................     20,400/(13)/          *                   --           --  
John T. Preston...........................     62,835/(14)/          *                   --           --  
William D. Young..........................     23,000/(15)/          *                   --           --  
Paul G. Brown, III........................     29,376/(16)/          *                   --           --  
William E. Heck...........................     13,208/(17)/          *                   --           --  
Mark W. John..............................     63,130/(18)/          *                   --           --  
All directors and executive officers                                                                      
   as a group (13 persons)................  2,878,390/(19)/       23.4%                  --           --   
 
</TABLE>
- - ------------------------
*    Represents less than 1% of the class.

                                      -16-
<PAGE>
 
/(1)/   Unless otherwise indicated, each of the stockholders designated above
        has sole voting and investment power with respect to the securities
        shown to be owned by such stockholder.
/(2)/   Includes 1,105,517 shares issuable upon conversion of Series B Preferred
        Stock.
/(3)/   Includes 1,103,448 shares issuable upon conversion of Series B Preferred
        Stock owned by Ethyl Corporation ("Ethyl"). Excludes 2,136,078 shares of
        Common Stock beneficially owned by Gryphon Ventures II, Limited
        Partnership ("Gryphon"), a limited partnership of which a wholly-owned
        subsidiary of Ethyl is the sole limited partner, and as to which Ethyl
        has no voting or dispositive power, based upon information provided in a
        Schedule 13D filed by Ethyl with the Securities and Exchange Commission
        on November 7, 1994, as amended.
/(4)/   Includes 275,862 shares of Common Stock issuable upon conversion of
        Series B Preferred Stock .
/(5)/   Represents 689,655 shares of Common Stock issuable upon conversion of
        Series B Preferred Stock.
/(6)/   Includes 551,724 shares of Common Stock issuable upon conversion of
        Series B Preferred Stock.
/(7)/   Represents 275,862 shares of Common Stock issuable upon conversion of
        Series B Preferred Stock.
/(8)/   Represents 237,310 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(9)/   Represents 23,000 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(10)/  Includes 2,136,078 shares of Common Stock held by Gryphon, which Mr.
        Lurier may be deemed to beneficially own due to his status as an
        affiliate of the general partner of Gryphon.
/(11)/  Includes 12,000 shares of Common Stock subject to stock options
        exercisable within 60 days of March 31, 1997.
/(12)/  Includes 205,440 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(13)/  Represents 20,400 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(14)/  Represents 62,835 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(15)/  Represents 23,000 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(16)/  Includes 27,876 shares of Common Stock subject to stock options that are
        exercisable within 60 days of March 31, 1997.
/(17)/  Represents 13,208 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(18)/  Represents 63,130 shares of Common Stock subject to stock options that
        are exercisable within 60 days of March 31, 1997.
/(19)/  Includes an aggregate of 694,262 shares of Common Stock subject to stock
        options that are exercisable within 60 days of March 31, 1997. Includes
        2,136,078 shares of Common Stock held by Gryphon which Mr. Lurier may be
        deemed to beneficially own due to his status as an affiliate of the
        general partner of Gryphon.


                         COMPLIANCE WITH SECTION 16(A)

     Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
the Company's directors and officers, and persons who own more than ten percent
of the Common Stock, to file initial reports of ownership and reports of changes
in ownership (Forms 3, 4, and 5) of Common Stock with the Securities and
Exchange Commission (the "SEC") and The Nasdaq Stock Market. Officers, directors
and greater than ten percent stockholders are required by SEC regulation to
furnish to Company with copies of all such forms that they file.

     To the Company's knowledge, based solely on the Company's review of the
copies of such reports received by the Company and on written representations by
certain reporting persons that no reports on Form 5 were required, the Company
believes that during the fiscal year ended December 31, 1996, all Section 16(a)
filing requirements applicable to its officers, directors and ten percent
stockholders were complied with, except for one late filing on Form 3 relating
to the election of Jeffrey A. Nagel as an officer of the Company.

                                      -17-
<PAGE>
 
                           PROPOSALS OF STOCKHOLDERS

     Any proposal of a stockholder intended to be presented at the next annual
meeting must be received at the Company's principal executive offices no later
than December 31, 1997, if the proposal is to be considered for inclusion in the
Company's Proxy Statement relating to such meeting.

                             FINANCIAL INFORMATION

     A COPY OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K, INCLUDING ANY FINANCIAL
STATEMENTS AND SCHEDULES AND EXHIBITS THERETO, MAY BE OBTAINED WITHOUT CHARGE BY
WRITTEN REQUEST TO PAUL G. BROWN, III, VICE PRESIDENT OF FINANCE AND
ADMINISTRATION, ENERGY BIOSYSTEMS CORPORATION, 4200 RESEARCH FOREST DRIVE, THE
WOODLANDS, TEXAS 77381.

                                 OTHER MATTERS

     The Company will bear the cost of preparing and mailing proxy materials as
well as the cost of solicitation of proxies.  The Company will reimburse banks,
brokerage firms, custodians, nominees, and fiduciaries for their expenses in
sending proxy materials to the beneficial owners of Common Stock and Preferred
Stock.  The Company has retained Corporate Communications Center, Inc.
("Corporate Communications") to assist in the solicitation of proxies and will
pay approximately $800 for certain brokerage searches and proxy solicitations
performed by Corporate Communications.  In addition to solicitation by mail,
certain directors, officers and regular employees of the Company and Corporate
Communications may solicit proxies by fax, telex, telephone and personal
interview.

                                 By Order of the Board of Directors



                                 Paul G. Brown, III
                                 Vice President, Finance and Administration


May 1, 1997
The Woodlands, Texas

                                      -18-
<PAGE>
 
                                                                       EXHIBIT A
                         ENERGY BIOSYSTEMS CORPORATION

                             1997 STOCK OPTION PLAN


     1.   Purposes of the Plan.  The purposes of this Stock Option Plan are to
attract and retain the best available personnel for positions of substantial
responsibility, to provide additional incentive to Employees and Consultants of
the Company and its Subsidiaries and to promote the success of the Company's
business.  Options granted under this Plan may be incentive stock options (as
defined under Section 422 of the Code) or nonqualified stock options, as
determined by the Administrator at the time of grant of an option and subject to
the applicable provisions of Section 422 of the Code, as amended, and the
regulations promulgated thereunder.  No Incentive Stock Options may be granted
under this Plan unless this Plan has been approved by the stockholders of the
Company.

     2.   Definitions.  As used herein, the following definitions shall apply:

          (a) "Administrator" means the Board or any of its Committees, as
     applicable, that is administering the Plan pursuant to Section 4 of the
     Plan.

          (b) "Board" means the Board of Directors of the Company.

          (c) "Code" means the Internal Revenue Code of 1986, as amended.

          (d) "Committee" means the Committee appointed by the Board of
     Directors in accordance with paragraph (a) of Section 4 of the Plan.

          (e) "Company" means Energy BioSystems Corporation, a Delaware
     corporation.

          (f) "Consultant" means any consultant or advisor to the Company or any
     Parent or Subsidiary.

          (g) "Continuous Status as an Employee" means the absence of any
     interruption or termination of the employment relationship by the Company
     or any Subsidiary.  Continuous Status as an Employee shall not be
     considered interrupted in the case of: (i) any leave of absence approved by
     the Board, including sick leave, military leave, or any other personal
     leave; provided, however, that for purposes of Incentive Stock Options,
     such leave is for a period of not more than ninety (90) days, unless
     reemployment upon the expiration of such leave is guaranteed by contract or
     statute, or unless provided otherwise pursuant to Company policy adopted
     from time to time; or (ii) in the case of transfers between locations of
     the Company or between the Company, its Subsidiaries or its successor.

          (h) "Employee" means any person, including officers and directors,
     employed by the Company or any Parent or Subsidiary of the Company.  The
     payment of a director's fee by the Company shall not be sufficient to
     constitute "employment" by the Company.

          (i) "Exchange Act" means the Securities Exchange Act of 1934, as
     amended.

          (j) "Fair Market Value" means, as of any date, the value of Stock
     determined as follows:

               (i) If the Stock is listed on any established stock exchange or a
          national market system, including without limitation The Nasdaq
          National Market, its Fair Market Value shall be the closing sales
          price for such stock (or the closing bid, if no sales were reported,
          as quoted on such system or exchange or the exchange with the greatest
          volume of trading in Stock for the last market trading day 

                                      A-1
<PAGE>
 
          prior to the time of determination) as reported in the Wall Street
          Journal or such other source as the Administrator deems reliable;

               (ii) If the Stock is quoted on The Nasdaq Stock Market (but not
          on The Nasdaq National Market) or regularly quoted by a recognized
          securities dealer but selling prices are not reported, its Fair Market
          Value shall be the mean between the high and low asked prices for the
          Stock; or

               (iii)  In the absence of an established market for the Stock, the
          Fair Market Value thereof shall be determined in good faith by the
          Administrator.

          (k) "Incentive Stock Option" means an Option intended to qualify as an
     incentive stock option within the meaning of Section 422 of the Code.

          (l) "Nonqualified Stock Option" means an Option not intended to
     qualify as an Incentive Stock Option.

          (m) "Option" means a stock option granted pursuant to the Plan.

          (n) "Optioned Stock" means the Stock subject to an Option.

          (o) "Optionee" means an Employee or Consultant who receives an Option.

          (p) "Parent" means a "parent corporation," whether now or hereafter
     existing, as defined in Section 424(e) of the Code.

          (q) "Plan" means this 1997 Stock Option Plan.

          (r) "Share" means a share of the Stock, as adjusted in accordance with
     Section 12 of the Plan.

          (s) "Stock" means the Common Stock, par value $.01 per share, of the
     Company;

          (t) "Subsidiary" means a "subsidiary corporation," whether now or
     hereafter existing, as defined in Section 424(f) of the Code.

     3.   Stock Subject to the Plan.  Subject to the provisions of Section 12 of
the Plan, the maximum number of shares of Stock which may be optioned and sold
under the Plan is 100,000 shares.  The shares may be authorized, but unissued,
or reacquired Stock.

     If an Option should expire or become unexercisable for any reason without
having been exercised in full, the unpurchased Shares which were subject thereto
shall, unless the Plan shall have been terminated, become available for future
grant under the Plan.

     4.   Administration of the Plan.

          (a)  Procedure.

          (i) Administration With Respect to Directors and Officers.  With
     respect to grants of Options to Employees who are also officers or
     directors of the Company, the Plan shall be administered by (A) the Board
     or (B) a Committee designated by the Board to administer the Plan, which
     Committee shall be constituted in such a manner as to permit the Plan to
     comply with Rule 16b-3 promulgated under the Exchange Act or any successor
     thereto ("Rule 16b-3") with respect to a plan intended to qualify
     thereunder as a discretionary plan.   Once appointed, such Committee shall
     continue to serve in its designated capacity until 

                                      A-2
<PAGE>
 
     otherwise directed by the Board. From time to time the Board may increase
     the size of the Committee and appoint additional members thereof, remove
     members (with or without cause) and appoint new members in substitution
     therefor, fill vacancies, however caused, and remove all members of the
     Committee and thereafter directly administer the Plan, all to the extent
     permitted by Rule 16b-3 with respect to a plan intended to qualify
     thereunder as a discretionary plan. Notwithstanding the foregoing, the Plan
     shall not be administered by the Board if (a) the Company and its officers
     and directors are then subject to the requirements of Section 16 of the
     Exchange Act and (b) the Board's administration of the Plan would prevent
     the Plan from complying with Rule 16b-3.

          (ii) Multiple Administrative Bodies.  If permitted by Rule 16b-3, the
     Plan may be administered by different bodies with respect to directors,
     non-director officers and Employees who are neither directors nor officers.

          (iii)  Administration With Respect to Consultants and Other Employees.
     With respect to grants of Options to Employees or Consultants who are
     neither directors nor officers of the Company, the Plan shall be
     administered by (A) the Board or (B) a Committee designated by the Board,
     which Committee shall be constituted in such a manner as to satisfy the
     legal requirements relating to the administration of incentive stock option
     plans, if any, of corporate and securities laws applicable to the Company
     and of the Code (the "Applicable Laws").  Once appointed, such Committee
     shall continue to serve in its designated capacity until otherwise directed
     by the Board.  From time to time the Board may increase the size of the
     Committee and appoint additional members thereof, remove members (with or
     without cause) and appoint new members in substitution therefor, fill
     vacancies, however caused, and remove all members of the Committee and
     thereafter directly administer the Plan, all to the extent permitted by the
     Applicable Laws.

          (b) Powers of the Administrator.  Subject to the provisions of the
Plan and in the case of a Committee, the specific duties delegated by the Board
to such Committee, the Administrator shall have the authority, in its
discretion:

          (i) to determine the Fair Market Value of the Stock, in accordance
     with Section 2(j) of the Plan;

          (ii) to select the officers, Consultants and Employees to whom Options
     may from time to time be granted hereunder;

          (iii)  to determine whether and to what extent Options are granted
     hereunder;

          (iv) to determine the number of shares of Stock to be covered by each
     such award granted hereunder;

          (v) to approve forms of agreement for use under the Plan;

          (vi) to determine the terms and conditions, not inconsistent with the
     terms of the Plan, of any award granted hereunder (including, but not
     limited to, the per share exercise price for the Shares to be issued
     pursuant to the exercise of an Option and any restriction or limitation, or
     any vesting acceleration or waiver of forfeiture restrictions regarding any
     Option or other award and/or the shares of Stock relating thereto, based in
     each case on such factors as the Administrator shall determine, in its sole
     discretion);

          (vii)  to determine whether and under what circumstances an Option may
     be bought-out for cash under subsection 9(f);

          (viii)  to determine whether, to what extent and under what
     circumstances Stock and other amounts payable with respect to an award
     under this Plan shall be deferred either automatically or at the election
     of the participant (including providing for and determining the amount, if
     any, of any deemed earnings on any deferred amount during any deferral
     period); and

                                      A-3
<PAGE>
 
          (ix) to reduce the exercise price of any Option to the then current
     Fair Market Value if the Fair Market Value of the Stock covered by such
     Option shall have declined since the date the Option was granted.

          (c) Effect of Committee's Decision.  All decisions, determinations and
interpretations of the Administrator shall be final and binding on all Optionees
and any other holders of any Options.  Neither the Board, the Committee nor any
member thereof shall be liable for any act, omission, interpretation,
construction or determination made in connection with the Plan in good faith,
and the members of the Board and of the Committee shall be entitled to
indemnification and reimbursement by the Company in respect of any claim, loss,
damage or expense (including counsel fees) arising therefrom to the full extent
permitted by law.

     5.   Eligibility.

          (a) Nonqualified Stock Options may be granted to Employees and
Consultants.  Incentive Stock Options may be granted only to Employees.  An
Employee or Consultant who has been granted an Option may, if he is otherwise
eligible, be granted an additional Option or Options.

          (b) Each Option shall be designated in the written option agreement as
either an Incentive Stock Option or a Nonqualified Stock Option.  However,
notwithstanding such designations, to the extent that the aggregate Fair Market
Value of the Shares with respect to which Options designated as Incentive Stock
Options are exercisable for the first time by any Optionee during any calendar
year (under all plans of the Company or any Parent or Subsidiary) exceeds
$100,000, such excess Options shall be treated as Nonqualified Stock Options.

          (c) For purposes of Section 5(b), Incentive Stock Options shall be
taken into account in the order in which they were granted, and the Fair Market
Value of the Shares shall be determined as of the time the Option with respect
to such Shares is granted.

          (d) The Plan shall not confer upon any Optionee any right with respect
to continuation of employment or consulting relationship with the Company, nor
shall it interfere in any way with his right or the Company's right to terminate
his employment or consulting relationship at any time, with or without cause,
unless otherwise agreed in writing by the Company and such Optionee.

          (e) The maximum number of shares subject to Options which may be
issued to any Optionee under the Plan during any period of three consecutive
years is 100,000 shares.

     6.   Term of Plan.  The Plan shall become effective upon its adoption by
the Board of Directors.  It shall continue in effect until January 14, 2007,
unless extended by the Board or sooner terminated under Section 14 of the Plan.
No grants of Options will be made pursuant to the Plan after January 14, 2007.

     7.   Term of Option.  The term of each Option shall be the term stated in
the Option Agreement; provided, however, that in the case of an Incentive Stock
Option, the term shall be no more than ten (10) years from the date of grant
thereof or such shorter term as may be provided in the Option Agreement.
However, in the case of an Incentive Stock Option granted to an Optionee who, at
the time the Option is granted, owns Stock representing more than ten percent
(10%) of the voting power of all classes of stock of the Company or any Parent
or Subsidiary, the term of the Option shall be five (5) years from the date of
grant thereof or such shorter term as may be provided in the Option Agreement.

     8.   Option Exercise Price and Consideration.

          (a) The per share exercise price for the Shares to be issued pursuant
to exercise of an Option shall be such price as is determined by the
Administrator, provided that, in the case of an Incentive Stock Option:

              (i) granted to an Employee who, at the time of the grant of such
     Incentive Stock Option, owns stock representing more than ten percent (10%)
     of the voting power of all classes of stock of the Company or 

                                      A-4
<PAGE>
 
     any Parent or Subsidiary, the per Share exercise price shall be no less
     than 110% of the Fair Market Value per Share on the date of grant.

              (ii) granted to any Employee, the per Share exercise price shall
     be no less than 100% of the Fair Market Value per Share on the date of
     grant.

          (b) The consideration to be paid for the Shares to be issued upon
exercise of an Option, including the method of payment, shall be determined by
the Administrator (and, in the case of an Incentive Stock Option, shall be
determined at the time of grant) and may consist entirely of (1) cash, (2)
check, (3) promissory note, (4) other shares of the Company's capital stock
which (x) in the case of shares of the Company's capital stock acquired upon
exercise of an Option either have been owned by the Optionee for more than six
months on the date of surrender or were not acquired, directly or indirectly,
from the Company, and (y) have a Fair Market Value on the date of surrender
equal to the aggregate exercise price of the Shares as to which said Option
shall be exercised, (5) authorization for the Company to retain from the total
number of Shares as to which the Option is exercised that number of Shares
having a Fair Market Value on the date of exercise equal to the exercise price
for the total number of Shares as to which the Option is exercised, (6) delivery
of a properly executed exercise notice together with irrevocable instructions to
a broker to promptly deliver to the Company the amount of sale or loan proceeds
required to pay the exercise price, (7) any combination of the foregoing methods
of payment, or (8) such other consideration and method of payment for the
issuance of Shares to the extent permitted under applicable laws.

     9.   Exercise of Option.

          (a) Procedure for Exercise; Rights as a Stockholder.  Any Option
granted hereunder shall be exercisable at such times and under such conditions
as determined by the Administrator, including performance criteria with respect
to the Company and/or the Optionee, and as shall be permissible under the terms
of the Plan.  An Option may not be exercised for a fraction of a Share.

     An Option shall be deemed to be exercised, and the Optionee deemed to be a
stockholder of the Shares being purchased upon exercise, when written notice of
such exercise has been given to the Company in accordance with the terms of the
Option by the person entitled to exercise the Option and full payment for the
Shares with respect to which the Option is exercised has been received by the
Company.  Full payment may, as authorized by the Board, consist of any
consideration and method of payment allowable under Section 8(b) of the Plan.

     Exercise of an Option in any manner shall result in a decrease in the
number of Shares which thereafter may be available, both for purposes of the
Plan and for sale under the Option, by the number of Shares as to which the
Option is exercised.

          (b) Termination of Employment.  In the event of termination of an
Optionee's relationship as a Consultant (unless such termination is for purposes
of becoming an Employee of the Company) or Continuous Status as an Employee with
the Company (as the case may be), such Optionee may, but only within ninety (90)
days (or such other period of time as is determined by the Board, with such
determination in the case of an Incentive Stock Option being made at the time of
grant of the Option and not exceeding ninety (90) days) after the date of such
termination (but in no event later than the expiration date of the term of such
Option as set forth in the Option Agreement), exercise his Option to the extent
that Optionee was entitled to exercise it at the date of such termination.  To
the extent that Optionee was not entitled to exercise the Option at the date of
such termination, or if Optionee does not exercise such Option to the extent so
entitled within the time specified herein, the Option shall terminate.

          (c) Disability of Optionee.  Notwithstanding the provisions of Section
9(b) above, in the event of termination of an Optionee's relationship as a
Consultant or Continuous Status as an Employee as a result of his total and
permanent disability (as defined in Section 22(e)(3) of the Code), Optionee may,
but only within twelve (12) months from the date of such termination (but in no
event later than the expiration date of the term of such Option as set forth in
the Option Agreement), exercise the Option to the extent otherwise entitled to
exercise it at the date of such 

                                      A-5
<PAGE>
 
termination. To the extent that Optionee was not entitled to exercise the Option
at the date of termination, or if Optionee does not exercise such Option to the
extent so entitled within the time specified herein, the Option shall terminate.

          (d) Death of Optionee.  In the event of the death of an Optionee, the
Option may be exercised, at any time within twelve (12) months following the
date of death (but in no event later than the expiration date of the term of
such Option as set forth in the Option Agreement), by the Optionee's estate or
by a person who acquired the right to exercise the Option by bequest or
inheritance, but only to the extent the Optionee was entitled to exercise the
Option at the date of death.  To the extent that Optionee was not entitled to
exercise the Option at the date of termination, or if the Optionee's estate (or
such other person who acquired the right to exercise the Option) does not
exercise such Option to the extent so entitled within the time specified herein,
the Option shall terminate.

          (e) Rule 16b-3.  Options granted to persons subject to Section 16(b)
of the Exchange Act must comply with Rule 16b-3 and shall contain such
additional conditions or restrictions as may be required thereunder to qualify
for the maximum exemption from Section 16 of the Exchange Act with respect to
Plan transactions.

          (f) Buyout Provisions.  The Administrator may at any time offer to buy
out for a payment in cash or Shares, an Option previously granted, based on such
terms and conditions as the Administrator shall establish and communicate to the
Optionee at the time that such offer is made.

     10.  Non-Transferability of Options.  The Option may not be sold, pledged,
assigned, hypothecated, transferred, or disposed of in any manner other than by
will or by the laws of descent or distribution and may be exercised, during the
lifetime of the Optionee, only by the Optionee.

     11.  Stock Withholding to Satisfy Withholding Tax Obligations.  At the
discretion of the Administrator, Optionees may satisfy withholding obligations
as provided in this paragraph.  When an Optionee incurs tax liability in
connection with an Option, which tax liability is subject to tax withholding
under applicable tax laws, and the Optionee is obligated to pay the Company an
amount required to be withheld under applicable tax laws, the Optionee may
satisfy the withholding tax obligation by electing to have the Company withhold
from the Shares to be issued upon exercise of the Option, that number of Shares
having a Fair Market Value equal to the amount required to be withheld.  The
Fair Market Value of the Shares to be withheld shall be determined on the date
that the amount of tax to be withheld is to be determined (the "Tax Date").

     All elections by an Optionee to have Shares withheld for this purpose shall
be made in writing in a form acceptable to the Administrator and shall be
subject to the following restrictions:

          (a) the election must be made on or prior to the applicable Tax Date;

          (b) once made, the election shall be irrevocable as to the particular
     Shares of the Option as to which the election is made;

          (c) all elections shall be subject to the consent or disapproval of
     the Administrator; and

          (d) if the Optionee is subject to Rule 16b-3, the election must comply
     with the applicable provisions of Rule 16b-3 and shall be subject to such
     additional conditions or restrictions as may be required thereunder to
     qualify for the maximum exemption from Section 16 of the Exchange Act with
     respect to Plan transactions.

     In the event the election to have Shares withheld is made by an Optionee
and the Tax Date is deferred under Section 83 of the Code because no election is
filed under Section 83(b) of the Code, the Optionee shall receive the full
number of Shares with respect to which the Option is exercised but such Optionee
shall be unconditionally obligated to tender back to the Company the proper
number of Shares on the Tax Date.

                                      A-6
<PAGE>
 
     12.  Changes in the Company's Capital Structure. The existence of
outstanding Options shall not affect in any way the right or power of the
Company or its stockholders to make or authorize any or all adjustments,
recapitalizations, reorganizations or other changes in the Company's capital
structure or its business, or any merger or consolidation of the Company, or any
issue of bonds, debentures, preferred or prior preference stock ahead of or
affecting the Stock or the rights thereof, or the dissolution or liquidation of
the Company, or any sale or transfer of all or any part of its assets or
business, or any other corporate act or proceeding, whether of a similar
character or otherwise.

     If the Company shall effect a subdivision or consolidation of shares or
other capital readjustment, the payment of a stock dividend, or other increase
or reduction of the number of shares of the Stock outstanding, without receiving
compensation therefor in money, services or property, then (a) the number,
class, and per share price of shares of Stock subject to outstanding Options
hereunder shall be appropriately adjusted in such a manner as to entitle an
Optionee to receive upon exercise of an Option, for the same aggregate cash
consideration, the same total number and class of shares as he would have
received had he exercised his Option in full immediately prior to the event
requiring the adjustment; and (b) the number and class of shares of Stock then
reserved for issuance under the Plan shall be adjusted by substituting for the
total number and class of shares of Stock then reserved that number and class of
shares of stock that would have been received by the owner of an equal number of
outstanding shares of each class of Stock as the result of the event requiring
the adjustment.

     If the Company shall be a party to a merger or a similar reorganization
after which the Company is not the surviving corporation, or if there is a sale
of all or substantially all the Common Stock or a sale of all or substantially
all of the assets of the Company, or if the Company is to be liquidated or
dissolved (any of which events shall constitute a "Significant Transaction"),
then, subject to the provisions hereof, the Administrator, in its discretion,
may accelerate the vesting of all outstanding Options or take such other action
with respect to outstanding Options as it deems appropriate, including, without
limitation, canceling such outstanding Options and paying the Optionees an
amount equal to the value of such Options, as determined by the Board.

     Notwithstanding the foregoing, if a Significant Transaction shall occur in
connection with or following a Change in Control (as defined below), in
connection with which Significant Transaction the holder of any Option that is
not fully vested shall not receive, in respect of such Option, a substitute
award of stock options containing substantially similar terms to and having an
equal or greater fair market value than such Option, then the Administrator
shall either (i) accelerate the vesting of such Option within a reasonable time
prior to the completion of such Significant Transaction (such that the holder of
such Option would have the opportunity to participate in the Significant
Transaction on the same basis as holders of Stock, subject to such holder's
exercise of such Option) or (ii) cancel such Option in consideration of the
payment to the holder thereof of an amount (in cash) equal to the fair market
value of such Option. For purposes of the foregoing, the fair market value
attributable to Options shall be determined by the Administrator either, at its
election, (x) in accordance with the Black-Scholes method (for purposes of which
volatility shall be measured over the preceding one year period and the risk-
free interest rate shall be the rate of U.S. treasury bills with a maturity
corresponding to the remaining term of such Option) or (y) to be an amount equal
to the fair market value of the Stock subject to such Option less the exercise
price thereof and (ii) the fair market value of (A) any Options shall be
determined as of the date, either of the Change in Control or of the Significant
Transaction, that results in the greater fair market value of such Options, and
(B) any substitute award shall be determined as of the date of the Significant
Transaction.  A "Change in Control" shall be deemed to occur if:

          (i) any individual, entity or group (within the meaning of Section
     13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, as amended)
     shall become (directly or indirectly) the beneficial owner (within the
     meaning of Rule 13d-3 promulgated under such Act) of more than 50% of the
     combined voting power of the then outstanding voting securities of EBC
     entitled to vote generally in the election of directors ("Voting Power");
     or

          (ii) EBC's stockholders shall approve a merger or consolidation, sale
     or disposition of all or substantially all of EBC's assets or a plan of
     liquidation or dissolution of EBC, other than (A) a merger or consolidation
     in which the voting securities of EBC outstanding immediately prior thereto
     will become (by operation of law), or are to be  converted into voting
     securities of the surviving corporation or its parent 

                                      A-7
<PAGE>
 
     corporation that, immediately after such merger or consolidation, (x) are
     owned by the same person or entity or persons or entities that owned the
     voting securities of EBC immediately prior thereto and (y) possess at least
     75% of the Voting Power held by the voting securities of the surviving
     corporation or its parent corporation, or (B) a merger or consolidation
     effected to implement a recapitalization of EBC (or similar transaction) in
     which no person acquires more than 50% of the Voting Power.

     Except as expressly provided herein, the issue by the Company of shares of
stock of any class, or securities convertible into shares of stock of any class,
for cash or property, or for labor or services either upon direct sale or upon
the exercise of rights or warrants to subscribe therefor, or upon conversion of
shares or obligations of the Company convertible into such shares or other
securities, shall not affect, and no adjustment by reason thereof shall be made
with respect to, the number, class, or price of shares of Stock then subject to
outstanding Options.

     13.  Time of Granting Options.  The date of grant of an Option shall, for
all purposes, be the date on which the Administrator makes the determination
granting such Option, or such other date as is determined by the Administrator.
Notice of the determination shall be given to each Employee or Consultant to
whom an Option is so granted within a reasonable time after the date of such
grant.

     14.  Amendment and Termination of the Plan.

          (a) Amendment and Termination.  The Board may at any time amend,
alter, suspend or discontinue the Plan, but no amendment, alteration, suspension
or discontinuation shall be made which would impair the rights of any Optionee
under any grant theretofore made, without his or her consent.  In addition, to
the extent necessary and desirable to comply with Rule 16b-3 under the Exchange
Act or with Section 422 of the Code (or any other applicable law or regulation,
including the applicable requirements of The Nasdaq Stock Market or an
established stock exchange), the Company shall obtain stockholder approval of
any Plan amendment in such a manner and to such a degree as required.

          (b) Effect of Amendment or Termination.  Any such amendment or
termination of the Plan shall not affect Options already granted and such
Options shall remain in full force and effect as if this Plan had not been
amended or terminated, unless mutually agreed otherwise between the Optionee and
the Board, which agreement must be in writing and signed by the Optionee and the
Company.

     15.  Conditions Upon Issuance of Shares.  Shares shall not be issued
pursuant to the exercise of an Option unless the exercise of such Option and the
issuance and delivery of such Shares pursuant thereto shall comply with all
relevant provisions of law, including, without limitation, the Securities Act of
1933, as amended, the Exchange Act, the rules and regulations promulgated
thereunder, and the requirements of any stock exchange upon which the Shares may
then be listed, and shall be further subject to the approval of counsel for the
Company with respect to such compliance.

     As a condition to the exercise of an Option, the Company may require the
person exercising such Option to represent and warrant at the time of any such
exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of
counsel for the Company, such a representation is required by any of the
aforementioned relevant provisions of law.

     16.  Reservation of Shares.  The Company, during the term of this Plan,
will at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.

     The inability of the Company to obtain authority from any regulatory body
having jurisdiction, which authority is deemed by the Company's counsel to be
necessary to the lawful issuance and sale of any Shares hereunder, shall relieve
the Company of any liability in respect of the failure to issue or sell such
Shares as to which such requisite authority shall not have been obtained.

     17.  Agreements.  Options shall be evidenced by written agreements ("Option
Agreement") in such form as the applicable Administrator shall approve from time
to time.

                                      A-8
<PAGE>
 
     18.  Information to Optionees.  The Company shall provide to each Optionee,
during the period for which such Optionee has one or more Options outstanding,
copies of all annual reports and other information which are generally provided
to all stockholders of the Company.  The Company shall not be required to
provide such information to persons whose duties in connection with the Company
assure their access to equivalent information.

     19.  Governing Law; Construction.  All rights and obligations under the
Plan shall be governed by, and the Plan shall be construed in accordance with,
the laws of the State of Delaware without regard to the principles of conflicts
of laws.  Titles and headings to Sections herein are for purposes of reference
only, and shall in no way limit, define or otherwise affect the meaning or
interpretation of any provisions of the Plan.

                                      A-9
<PAGE>
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<CAPTION> 
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                                                   ENERGY BIOSYSTEMS CORPORATION

                                      PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS OF
                                  THE COMPANY FOR THE ANNUAL MEETING OF STOCKHOLDERS JUNE 4, 1997

<S>        <C>
P          The undersigned hereby constitutes and appoints John H. Webb and Paul G. Brown, III, and each or either of them, his true
     and lawful attorneys and proxies with full power of substitution, for and in the name, place and stead of the undersigned, to
R    attend the Annual Meeting of Stockholders of Energy BioSystems Corporation to be held at the Company's offices, 4200 Research
     Forest Drive, The Woodlands, Texas on Wednesday, June 4, 1997, at 10:00 a.m., central daylight time, and any adjournment(s)
O    thereof, with all powers the undersigned would possess if personally present and to vote thereat, as provided on the reverse
     side of this card, the number of shares the undersigned would be entitled to vote if personally present. In accordance with
X    their discretion, said attorneys and proxies are authorized to vote upon such other business as may properly come before the
     meeting or any adjournment thereof.
Y
           Election of Directors, Nominees: Ramon Lopez, John H. Webb, R. James Comeaux, Edward B. Lurier, Thomas E. Messmore,
     Daniel J. Monticello, Ph.D., William E. Nasser, John S. Patton, and William D. Young. 
     1. ELECTION OF DIRECTORS [_] FOR, except vote withheld from the following nominee(s):
                              [_] WITHHELD

     -----------------------------------------------------------------------------------------------------------------------------
     2. Approval of the Company's 1997 Stock Option Plan.    [_]  FOR   [_]  AGAINST   [_]  ABSTAIN

     3. Ratification of the appointment of Arthur Andersen LLP as the Company's independent public accountants for the fiscal year
        ending December 31, 1997.                            [_]  FOR   [_]  AGAINST   [_]  ABSTAIN
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        Every properly signed proxy will be voted in accordance with the specifications made on the reverse side of this card.  If 
     not otherwise specified, this proxy will be voted for proposals 1, 2 and 3.  All prior proxies are hereby revoked.

                                                                Dated:________________________________, 1997

                                                                --------------------------------------------
                                                                               Signature(s)

                                                                --------------------------------------------
                                                                               Signature(s)


                                                                NOTE: Please sign exactly as name appears hereon.  Joint
                                                                owners should each sign.  When signing as attorney, executor,
                                                                administrator, trustee or guardian, please give full title
                                                                as such.

                                                                Change of address:

                                                                --------------------------------------------

                                                                --------------------------------------------

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