ENERGY BIOSYSTEMS CORP
8-K, 2000-05-24
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              _____________________

                                    FORM 8-K

             Current Report Filed Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934


                                 Date of Report
                 (Date of earliest event reported): May 23, 2000


                          ENERGY BIOSYSTEMS CORPORATION
             (Exact name of registrant as specified in its charter)

<TABLE>
<S>          <C>                               <C>                             <C>

              Delaware                                0-21130                              04-3078857


    (State or other jurisdiction of            (Commission File Number)        (I.R.S. Employer Identification No.)
    incorporation or organization)

</TABLE>

                           4200 Research Forest Drive
                           The Woodlands, Texas 77381
                              (Address of principal
                                executive offices
                                  and zip code)


                                 (281) 364-6100
                         (Registrant's telephone number,
                              including area code)

                          _____________________________

================================================================================

<PAGE>

ITEM 5. OTHER EVENTS

         On May 23, 2000, Energy BioSystems Corporation (the "Company") issued a
press release  announcing  that it has entered into a licensing  agreement  with
Genencor  International  involving  the  Company's  proprietary  gene  shuffling
technology for "directed evolution." Under the agreement,  Genencor will use the
Company's  proprietary RACHITT technology to develop gene-based products for the
cleaning,  textiles,  grain  processing,   animal  feed,  and  food  ingredients
industries.

         The press release is filed as an exhibit to this Current Report on Form
8-K and is incorporated by reference herein.

ITEM 7.  EXHIBITS

         Exhibit 99.1      -- Press Release




<PAGE>



                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                     ENERGY BIOSYSTEMS CORPORATION

Date: May 23, 2000                   By: /s/ Paul G. Brown, III
                                         -------------------------------
                                              Paul G. Brown, III
                                              Vice President, Finance
                                                 and Administration
                                                 and Chief Financial Officer









                                                                 Exhibit 99.1

ENERGY BIOSYSTEMS SIGNS LICENSING AGREEMENT WITH
GENECOR FOR INDUSTRIAL ENZYME DEVELOPMENT



SIGNIFICANT   AGREEMENT   MARKS  MAJOR  VENTURE  FOR  COMPANY'S  GENE  SHUFFLING
TECHNOLOGY FOR INDUSTRIAL ENZYMES

THE  WOODLANDS,   Texas--(BUSINESS   WIRE)--May  23,  2000--  Energy  BioSystems
Corporation  (Nasdaq:ENBC-news)  announced  today  that  it has  entered  into a
licensing  agreement  with Genencor  International,  one of the world's  leading
industrial  biotechnology  companies,  involving Energy BioSystem's  proprietary
gene  shuffling  technology  for  "directed  evolution."  Under  the  agreement,
Genencor will use Energy BioSystem's  proprietary  RACHITT technology to develop
gene-based products for the cleaning,  textiles, grain processing,  animal feed,
and food ingredients industries.

Energy  BioSystems  is using its RACHITT gene  shuffling  technology - named for
"random chimeragenesis on transient templates" - to build extensive libraries of
hybrid  genes with  diverse,  targeted  properties  for  commercial  use.  "This
agreement  represents a perfect fit for our unique gene shuffling technology and
Genencor's  exacting enzyme  production  requirements,"  said Energy  BioSystems
President and CEO Peter  Policastro.  "We're pleased that Genencor,  a leader in
its field,  recognizes  the  strength of our  technology  platform as a means of
producing superior products."

The significant licensing agreement represents the first in a series of expected
agreements  with Genencor that will cover  research and  development  as well as
possible  expansion  into  additional  licensing  fields  for  agricultural  and
biomaterials  products.  It  includes  three  categories  of  payments:  upfront
licensing fees, milestone payments, and product royalties.

Since 1993,  Energy  BioSystems has been a leader in applying  molecular biology
and microbial processes to remove sulfur from petrochemical products for cleaner
reactions  and lower  costs.  This new  licensing  agreement  expands use of the
company's RACHITT technology into broader industrial  applications.  The company
is  expanding  use  of  the  technology  to   pharmaceutical   and  agricultural
applications. Reflecting its evolution into these broader biotechnology markets,
Energy BioSystems has requested its shareholders to approve changing its name to
Enchira Biotechnology Corporation in early June.

Energy  BioSystems'  RACHITT  technology  is  part  of  the  company's  directed
evolution  technology  platform that rapidly  creates hybrid genes that code for
proteins  with  desired  characteristics.  New genes are created in a controlled
laboratory  setting by combining  genes or gene  fragments  to produce  chimeric
genes that will direct the synthesis of these highly optimized proteins.  Energy
BioSystems  believes its RACHITT  technology,  coupled with its high  throughput
screening   capabilities,   offers  its  partners  substantial  advantages  over
competing technologies.

Genencor  International  is one of the largest  biotechnology  companies  in the
world.  It develops and markets  gene-based  products for use in the healthcare,
industrial  chemical,  and  agricultural  industries.  The company has principle
corporate offices in Palo Alto, California; Rochester, New York, and Leiden, The
Netherlands.  The company operates seven  manufacturing  sites in five countries
around the world.

Energy BioSystems Corporation (Nasdaq:ENBC-news),  of The Woodlands, Texas, is a
biotechnology   company  that  is  applying   proprietary,   directed  evolution
techniques to accelerate  development and commercialization of biocataylst-based
processes  for  the  pharmaceutical,   ag-bio,   industrial  enzyme,   chemical,
biodesulfurization,   and  petroleum   refining  and   petrochemicals   markets.
Additional information about Energy BioSystems is available at the company's web
site: www.energybiosystems.com

This document  contains  forward-looking  statements that are subject to certain
risks,  uncertainties  and  assumptions,  including  but  not  limited  to,  the
Company's need for additional  funds,  the ability to raise  sufficient funds on
acceptable terms, the pending dispute with Maxygen relative to their allegations
concerning confidentiality,  the technical uncertainty and risks associated with
commercialization  of  the  Company's  technology,  the  Company's  reliance  on
environmental  regulations  and the  uncertainty  of the  adoption  of any newly
proposed  regulations,  the market acceptance of the Company's  technology,  the
Company's dependence on collaboration partners,  competition, and the ability to
enforce and defend the Company's  patents and proprietary  technologies.  Should
one or more of such risks and  uncertainties  materialize,  or should underlying
assumptions  prove  incorrect,  actual  results may vary  materially  from those
indicated in such forward-looking statements. For a discussion of such risks and
assumptions,  see "Risk Factors" included in the Company's annual report on Form
10-K for the year ended December 31, 1999.

(Note to investors:  a conference call has been set up for this  announcement on
Tuesday,  May  23rd.  If you  would  like  to  call  in  for  Q&A,  please  call
800/847-8127.  Start time is 11:30 a.m. EDT and end time is scheduled  for 12:30
p.m. In addition,  "postview" is available  from 1:30 p.m. the 23rd to 1:30 p.m.
the 24th. Call 800/633-8284,  enter reservation No. 15317378, and enter passcode
N/A.)

Contact:
 Energy  BioSystems   Corporation
 Paul  G.  Brown  III,  281/364-6140
 or
 BMC   Communications/Trout   Group
 Brad  Miles  (for media inquiries)
 Jonathan Fassberg (for investor inquiries)
 212/477-9007



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