ENCHIRA BIOTECHNOLOGY CORP
10-Q, EX-11.1, 2000-08-14
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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EXHIBIT 11.1

              STATEMENT REGARDING COMPUTATION OF PER SHARE EARNINGS

         The following schedules reflect the information used in calculating the
number of shares in the computation of net loss per share for each of the
periods set forth in the Statements of Operations.




                                       17

<PAGE>


<TABLE>
<CAPTION>
                BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION
                        THREE MONTHS ENDED JUNE 30, 2000

Weighted Average Shares Outstanding:

      TOTAL              # DAYS
      SHARES              OUTSTANDING
<S>                                 <C>             <C>
         7,016,029   x               6    =          42,096,174
         7,018,059   x               4    =          28,072,236
         7,020,039   x              17    =         119,340,663
         7,020,342   x               5    =          35,101,710
         7,021,002   x              20    =         140,420,040
         7,034,921   x              40    =         281,396,840
                           -----------          ---------------
                                    92    =         646,427,663
                           ===========          ===============

                                                    646,427,663  / 92    =    7,026,388
                                                                             ==========

Loss Per Share:

Net Loss plus dividend accrual
 plus accretion of offering costs                  $ (1,952,478)   =          $  (0.28)
---------------------------------               ---------------              ==========
   Weighted Avg. Shares                               7,026,388

</TABLE>


                                                        18
<PAGE>


<TABLE>
<CAPTION>
                BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION
                        THREE MONTHS ENDED JUNE 30, 1999


Weighted Average Shares Outstanding:

      TOTAL                 # DAYS
      SHARES              OUTSTANDING
<S>                                 <C>              <C>
         2,180,358   x              33    =          71,951,814
         2,182,328   x               3    =           6,546,984
         2,315,330   x              13    =          30,099,290
         2,328,334   x               7    =          16,298,338
         2,354,737   x              15    =          35,321,055
         6,150,068   x              11    =          67,650,748
         6,569,557   x               9    =          59,126,013
                           -----------          ---------------
                                    91              286,994,242
                           ===========          ===============

                                                    286,994,242   /91    =    3,153,783
                                                                             ==========
Loss Per Share:

Net Loss plus dividend accrual
 plus accretion of offering costs                  $ (1,768,478)  =           $  (0.56)
---------------------------------               ---------------              ==========
   Weighted Avg. Shares                               3,153,783

</TABLE>






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<PAGE>


<TABLE>
<CAPTION>

                BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION
                         SIX MONTHS ENDED JUNE 30, 2000

Weighted Average Shares Outstanding:

      TOTAL              # DAYS
      SHARES              OUTSTANDING
<S>                                 <C>              <C>
         6,572,135   x               3    =          19,716,405
         6,574,135   x               7    =          46,018,945
         6,576,135   x              15    =          98,642,025
         6,578,135   x              14    =          92,093,890
         6,591,135   x               1    =           6,591,135
         6,596,135   x               6    =          39,576,810
         6,624,189   x               8    =          52,993,512
         6,629,189   x               1    =           6,629,189
         6,691,762   x               6    =          40,150,572
         6,706,762   x               1    =           6,706,762
         6,723,424   x               3    =          20,170,272
         6,734,224   x              14    =          94,279,136
         6,734,917   x               4    =          26,939,668
         6,772,512   x               6    =          40,635,072
         7,016,029   x               7    =          49,112,203
         7,018,059   x               4    =          28,072,236
         7,020,039   x              17    =         119,340,663
         7,020,342   x               5    =          35,101,710
         7,021,002   x              20    =         140,420,040
         7,034,921   x              40    =         281,396,840
                           -----------          ---------------
                                   182    =       1,244,587,085
                           ===========          ===============

                                                  1,244,587,085  / 182    =   6,838,391
                                                                             ==========

Loss Per Share:

Net Loss plus dividend accrual
 plus accretion of offering costs                  $ (3,729,777)   =          $  (0.55)
---------------------------------               ---------------              ==========
   Weighted Avg. Shares                               6,838,391

</TABLE>

                                                   20
<PAGE>




<TABLE>
<CAPTION>

                BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION
                         SIX MONTHS ENDED JUNE 30, 1999


Weighted Average Shares Outstanding:

      TOTAL                 # DAYS
      SHARES              OUTSTANDING
<S>                                 <C>              <C>
         2,179,124  x               19  =            41,403,356
         2,179,713  x               30  =            65,391,390
         2,180,358  x               74  =           161,346,492
         2,182,328  x                3  =             6,546,984
         2,315,330  x               13  =            30,099,290
         2,328,334  x                7  =            16,298,338
         2,354,737  x               15  =            35,321,055
         6,150,068  x               11  =            67,650,748
         6,569,557  x                9  =            59,126,013
                           -----------          ---------------

                                   181              483,183,666
                           ===========          ===============

                                                    483,183,666  /181    =    2,669,523
                                                                             ==========
Loss Per Share:

Net Loss plus dividend accrual
 PLUS ACCRETION OF OFFERING COSTS                  $ (4,272,321)    =         $  (1.60)
---------------------------------               ---------------              ==========
   Weighted Avg. Shares                               2,669,523

</TABLE>

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