ENERGY BIOSYSTEMS CORP
8-K, 2000-02-08
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              ---------------------
                                    FORM 8-K

             Current Report Filed Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934


                                 Date of Report
               (Date of earliest event reported): February 7, 2000


                          ENERGY BIOSYSTEMS CORPORATION
             (Exact name of registrant as specified in its charter)


<TABLE>
<S>                                           <C>                                <C>

               Delaware                                0-21130                                04-3078857


    (State or other jurisdiction of            (Commission File Number)          (I.R.S. Employer Identification No.)
    incorporation or organization)

</TABLE>

                           4200 Research Forest Drive
                           The Woodlands, Texas 77381
                              (Address of principal
                                executive offices
                                  and zip code)


                                 (281) 364-6100
                         (Registrant's telephone number,
                              including area code)
================================================================================

<PAGE>


ITEM 5. OTHER EVENTS

         On February 7, 2000,  Energy  BioSystems  Corporation  (the  "Company")
issued a press release  announcing that it has completed the  demonstration of a
new, proprietary gene shuffling technology. Gene shuffling is a method to create
a new,  proprietary  genes  coding for enzymes  with  improved  properties.  The
Company  has  successfully  applied  the  technology  to its  biodesulfurization
development  efforts and is now exploring  opportunities  for the  technology in
areas beyond biorefining including the chemical, pharmaceutical and agricultural
biotechnology sectors.

         The press release is filed as an exhibit to this Current Report on Form
8-K and is incorporated by reference herein.

ITEM 7.  EXHIBITS

         Exhibit 99.1      -- Press Release




<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            ENERGY BIOSYSTEMS CORPORATION

Date: February 7, 2000

                                            By:   /s/ Paul G. Brown, III
                                                  ------------------------
                                                  Paul G. Brown, III
                                                  Vice President, Finance and
                                                    Administration and Chief
                                                    Financial Officer









                              \                                EXHIBIT 99.1

Energy BioSystems Corporation Demonstrates Proprietary Gene Shuffling Technology



         THE  WOODLANDS,  TEXAS  (February  7,  2000)  .  .  .Energy  BioSystems
Corporation   (NASDAQ:ENBC)   announced   today  that  it  has   completed   the
demonstration of a new, proprietary gene shuffling technology. Gene shuffling is
a powerful  method to create  millions of new variant  genes  coding for enzymes
with improved properties. The company has successfully applied the technology to
its  biodesulfurization  development efforts and is now exploring  opportunities
for  the  technology  in  areas  beyond  biorefining   including  the  chemical,
pharmaceutical  and  agricultural  biotechnology  sectors.   "Difficulties  with
existing  methods to generate genetic  diversity  prompted us to develop our own
technologies,"  noted Dr. Daniel J.  Monticello,  Vice President of Research and
Development at ENBC. "We've  successfully used this new gene shuffling technique
in our  directed  evolution  program to combine the best  properties  of related
desulfurization   enzymes  and  generate  superior  strains.  Our  approach  has
important advantages over known technologies and has accelerated our development
program." Dr.  Monticello  will be disclosing  certain details of the technology
and its  implications  to ENBC's  projects at the IBC "Annual World  Congress on
Enzyme Technologies 2000" in February (www.ibcusa.com).
         Dr. Peter  Policastro,  CEO and President of ENBC,  indicated  that the
technology  was  part  of  a  comprehensive   effort  to  expand  the  Company's
capabilities.  "In 1999, we implemented a strategic  initiative to capitalize on
our unique genetic  capabilities.  The  demonstration  of our  proprietary  gene
shuffling technology creates both new and complementary business  opportunities.
Our gene  shuffling  technology  has already  made a  significant  impact on our
biodesulfurization  program.  We intend  to apply  these  capabilities  to other
projects in the ENBC pipeline and to other opportunities as we identify them."
         Energy  BioSystems  Corporation  is a  biotechnology  company  applying
state-of-the art,  proprietary  directed evolution  techniques to accelerate the
development and  commercialization of biocatalyst-based  processes for petroleum
refining,  petrochemicals and fine chemicals  production.  The Company's primary
focus has been development of biocatalytic  desulfurization (BDS), a proprietary
process  involving  the use of enzymes  to remove  sulfur  from oil.  Additional
information  about Energy  BioSystems  is available at the  company's  web site:
www.energybiosystems.com.
                                       ###



<PAGE>




         This document contains  forward-looking  statements that are subject to
certain risks, uncertainties and assumptions,  including but not limited to, the
company's  ability to raise  additional  capital on a timely  basis on favorable
terms,  the  development  of the company's  proprietary  technology,  government
regulations,  competitive  technologies,  and the  company's  ability to control
expenditures. Should one or more of such risks and uncertainties materialize, or
should  underlying   assumptions  prove  incorrect,   actual  results  may  vary
materially  from  those  indicated  in such  forward-looking  statements.  For a
discussion of such risks and  assumptions,  see "Risk  Factors"  included in the
company's annual report on Form 10-K for the year ended December 31, 1998.



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