INSURED MUNICIPALS INCOME TRUST 225TH INSURED MULTI SERIES
S-6EL24, 1997-09-30
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                                                            File No. 333-
                                                            CIK #896371
                   Securities and Exchange Commission
                      Washington, D.C.  20549-1004
                                Form S-6

For Registration under the Securities Act of 1933 of Securities of Unit
Investment Trusts Registered on Form N-8B-2.

A. Exact name of Trust:         Insured Municipals Income Trust,
                                225th Insured Multi-Series

B. Name of Depositor:           Van Kampen American Capital Distributors, Inc.

C. Complete address of Depositor's principal executive offices:

                                One Parkview Plaza
                                Oakbrook Terrace, Illinois  60181

D. Name and complete address of agents for service:

   Chapman and Cutler           Van Kampen American Capital Distributors, Inc.
   Attention:  Mark J. Kneedy   Attention:  Don G. Powell, Chairman
   111 West Monroe Street       One Parkview Plaza
   Chicago, Illinois  60603     Oakbrook Terrace, Illinois  60181

E. Title and amount of securities being registered:  
              An indefinite number of Units pursuant to Rule 24f-2.

F. Proposed maximum offering price to the public of the securities being
                   registered: indefinite.

G. Amount of filing fee:        $0.

H. Approximate date of proposed sale to the public:

   As soon as practicable after the effective date of the Registration
                                Statement

The registrant hereby amends this Registration Statement on such date or
dates  as may be necessary to delay its effective date until  the
registrant shall file a further amendment which specifically states that
this Registration Statement shall thereafter become effective  in
accordance with Section 8(a) of the Securities Act of 1933 or until the
Registration Statement shall become effective on such date as the
Commission, acting pursuant to said Section 8(a) may determine.


                    Insured Municipals Income Trust,
                       225th Insured Multi-Series
                                    
                          Cross Reference Sheet

                 Pursuant to Rule 404(c) of Regulation C
                    under the Securities Act of 1933
                                    
               (Form N-8B-2 Items Required by Instruction
                     1 as to Prospectus on Form S-6)

         Form N-8B-2                               Form S-6
         Item Number                         Heading in Prospectus

                I.  Organization and General Information

1. (a)  Name of trust                  )
   (b)  Title of securities issued     )  Prospectus Part I Front Cover Page

2. Name and address of Depositor       )  Part II-Introduction
                                       ) 
Part I-Summary of Essential Financial  
                                       )  Information
                                       )  Part II-Trust Administration

3. Name and address of Trustee         )  Part II-Introduction
                                       )
 Part I-Summary of Essential Financial
                                       )  Information
                                       )  Part II-Trust Administration

4. Name and address of principal       )  Part I-Other Matters-Underwriting
     underwriter                       )

5. Organization of trust               )  Part II-Introduction

6. Execution and termination of        )  Part II-Introduction
     Trust Indenture and Agreement     )  Part II-Trust Administration

7. Changes of Name                     )  *

8. Fiscal year                         )  *

9. Material Litigation                 )  *



    II.  General Description of the Trust and Securities of the Trust

10. General information regarding      )  Part II-Introduction
      trust's securities and rights    )  Part II-Unitholder Explanations
      of security holders              )  Part II-Trust Administration

11. Type of securities comprising      )  Part II-Introduction
      units                            )  Part I-Trust Information
                                       )  Part I-Portfolios

12. Certain information regarding      )  *
      periodic payment certificates    )

13. (a)  Load, fees, charges and       )  Part II-Introduction
      expenses                         )
 Part I-Summary of Essential Financial
                                       )  Information
                                       )  Part II-Unitholder Explanations
                                       )  Part I-Trust Information
                                       )  Part II-Trust Administration

    (b)  Certain information regard-   )  *
           ing periodic payment plan   )
           certificates                )

    (c)  Certain percentages           )
 Part I-Summary of Essential Financial
                                       )  Information
                                       )  Part II-Unitholder Explanations

    (d)  Certain other fees,           )  Part II-Unitholder Explanations
           expenses or charges         )  Part II-Trust Administration
           payable by holders          )

    (e)  Certain profits to be         )  Part II-Unitholder Explanations
           received by depositor,      )  Part I-Other Matters-Underwriting
           principal underwriter,      )  Part I-Notes to Portfolios
           trustee or affiliated       )
           persons                     )   

    (f)  Ratio of annual charges       )  *
           to income                   )

14. Issuance of trust's securities     )  Part II-Unitholder Explanations

15. Receipt and handling of payments   )  *
      from purchasers                  )

16. Acquisition and disposition of     )  Part II-Introduction
      underlying securities            )  Part II-Unitholder Explanations
                                       )  Part II-Trust Administration

17. Withdrawal or redemption           )  Part II-Unitholder Explanations
                                       )  Part II-Trust Administration

18. (a)  Receipt and disposition       )  Part II-Introduction
      of income                        )  Part II-Unitholder Explanations
  
    (b)  Reinvestment of distribu-     )  *
           tions                       )

    (c)  Reserves or special funds     )  Part II-Unitholder Explanations
                                       )  Part II-Trust Administration

    (d)  Schedule of distributions     )  *
 
19. Records, accounts and reports      )  Part II-Unitholder Explanations
                                       )  Part II-Trust Administration

20. Certain miscellaneous provisions   )  Part II-Trust Administration
      of Trust Agreement               )

21. Loans to security holders          )  *

22. Limitations on liability           )  Part I-Portfolios
                                       )  Part II-Trust Administration

23. Bonding arrangements               )  *

24. Other material provisions of       )  *
      trust indenture or agreement     )


    III.  Organization, Personnel and Affiliated Persons of Depositor

25. Organization of Depositor          )  Part II-Trust Administration

26. Fees received by Depositor         )  Part II-Trust Administration

27. Business of Depositor              )  Part II-Trust Administration
  
28. Certain information as to          )
      officials and affiliated         )  *
      persons of Depositor             )

29. Companies owning securities of     )  *
      Depositor                        )
 
30. Controlling persons of Depositor   )  *

31. Compensation of Directors          )  *

32. Compensation of Directors          )  *

33. Compensation of Employees          )  *

34. Compensation to other persons      )  Part II-Unitholder Explanations


             IV.  Distribution and Redemption of Securities

35. Distribution of trust's            )  Part II-Introduction
      securities by states             )  Part II-Settlement of Bonds 
                                          in the Trusts

36. Suspension of sales of trust's     )  *
      securities                       )

37. Revocation of authority to         )  *
      distribute                       )

38. (a)  Method of distribution        )

    (b)  Underwriting agreements       )  Part II-Unitholder Explanations

    (c)  Selling agreements            )

39. (a)  Organization of principal     )
           underwriter                 )
                                       )  Part II-Trust Administration
    (b)  N.A.S.D. membership by        )
           principal underwriter       )

40. Certain fees received by           )  *
      principal underwriter            )

41. (a)  Business of principal         )  Part II-Trust Administration
      underwriter                      )

    (b)  Branch offices of principal   )  *
      underwriter                      )

    (c)  Salesmen of principal         )  *
      underwriter                      )

42. Ownership of securities of the     )  *
      trust                            )

43. Certain brokerage commissions      )
      received by principal            )  *
      underwriter                      )

44. (a)  Method of valuation           )  Part II-Introduction
                                       )
 Part I-Summary of Essential Financial
                                       )  Information
                                       )  Part II-Unitholder Explanations
                                       )  Part II-Trust Administration

    (b)  Schedule as to offering       )  *
           price                       )

    (c)  Variation in offering price   )  Part II-Unitholder Explanations
           to certain persons          )
  
45. Suspension of redemption rights    )  *

46. (a)  Redemption valuation          )  Part II-Unitholder Explanations
                                       )  Part II-Trust Administration

    (b)  Schedule as to redemption     )  *
      price                            )

47. Purchase and sale of interests     )  Part II-Unitholder Explanations
      in underlying securities         )  Part II-Trust Administration


           V.  Information Concerning the Trustee or Custodian

48. Organization and regulation of     )  Part II-Trust Administration
      trustee                          )
  
49. Fees and expenses of trustee       )
 Part I-Summary of Essential Financial
                                       )  Information
                                       )  Part II-Trust Administration

50. Trustee's lien                     )  Part II-Trust Administration


     VI.  Information Concerning Insurance of Holders of Securities

51. Insurance of holders of trust's    )
      securities                       )  *


                       VII.  Policy of Registrant

52. (a)  Provisions of trust agree-    )
           ment with respect to        )
           replacement or elimi-       )  Part II-Trust Administration
           nation of portfolio         )
           securities                  )

    (b)  Transactions involving        )
           elimination of underlying   )  *
           securities                  )

    (c)  Policy regarding substitu-    )  Part II-Trust Administration
           tion or elimination of      )
           underlying securities       )

    (d)  Fundamental policy not        )  *
           otherwise covered           )

53. Tax Status of trust                )  Part I-Trust Information
                                       )  Part II-Federal Tax Status


              VIII.  Financial and Statistical Information

54. Trust's securities during          )  *
      last ten years                   )

55.                                    )
                                       )

56. Certain information regarding      )  *
                                       )

57. Periodic payment certificates      )

58.                                    )
  
59. Financial statements (Instruc-     )  Part I-Other Matters
      tions 1(c) to Form S-6)          )

__________________________________
* Inapplicable, omitted, answer negative or not required



                                    
             Preliminary Prospectus Dated September 30, 1997
                                    
                     Insured Municipals Income Trust
                                    
                                            225th Insured Multi-Series
                                             (A Unit Investment Trust)
     
     The  attached  final Prospectus for a prior Series of  the  Fund  is
hereby used as a preliminary Prospectus for the above stated Series.  The
narrative information and structure of the attached final Prospectus will
be  substantially  the  same  as that of the final  Prospectus  for  this
Series.  Information with respect to pricing, the number of Units,  dates
and summary information regarding the characteristics of securities to be
deposited in this Series is not now available and will be different since
each   Series  has  a  unique  Portfolio.   Accordingly  the  information
contained  herein with regard to the previous Series should be considered
as  being  included  for informational purposes  only.   Ratings  of  the
securities in this Series are expected to be comparable to those  of  the
securities  deposited  in the previous Series.   However,  the  Estimated
Current  Return  for  this Series will depend on the interest  rates  and
offering  prices of the securities in this Series and may vary materially
from that of the previous Series.
     
     A  registration statement relating to the units of this Series  will
be  filed  with the Securities and Exchange Commission but  has  not  yet
become  effective.  Information contained herein is subject to completion
or  amendment.   Such  Units may not be sold nor  may  offer  to  buy  be
accepted  prior to the time the registration statement becomes effective.
This Prospectus shall not constitute an offer to sell or the solicitation
of  an offer to buy nor shall there be any sale of the Units in any state
in  which  such  offer, solicitation or sale would be unlawful  prior  to
registration  or  qualification under the securities  laws  of  any  such
state.

(Incorporated herein by reference is the final prospectus from Insured
Municipals Income Trust, 223rd Insured Multi-Series (Registration No. 333-
30341) as filed on August 28, 1997, which shall be used as a preliminary
prospectus for the current Series of the Fund.)

                   Contents of Registration Statement
     
     This  Amendment  of Registration Statement comprises  the  following
papers and documents:

     The facing sheet
     The Cross-Reference sheet
     The Prospectus
     The signatures
     The consents of independent public accountants, ratings
         services and legal counsel

The following exhibits:

1.1     Copy of Trust Agreement (to be supplied by amendment).

1.4     Copy  of Municipal Bond Fund Portfolio Insurance Policies issued  by
        AMBAC  Indemnity  Corporation  and/or Financial  Guaranty  Insurance
        Company for any Trust (to be supplied by amendment).

1.5     Copy of Agreement Among Underwriters (to be supplied by amendment).

3.1     Opinion  and  consent of counsel as to legality of securities  being
        registered (to be supplied by amendment).

3.2     Opinion  of  counsel as to Federal income tax status  of  securities
        being registered (to be supplied by amendment).

3.3     Opinion  and consent of counsel as to New York income tax status  of
        the Fund under New York law (to be supplied by amendment).

4.1     Consent of Interactive Data Corp. (to be supplied by amendment).

4.2     Consent of Standard & Poor's (to be supplied by amendment).

4.3     Consent of Grant Thornton LLP (to be supplied by amendment).
 
EX-27   Financial Data Schedules (to be supplied by amendment).


                               Signatures
     
     Pursuant  to  the requirements of the Securities Act  of  1933,  the
Registrant,  Insured Municipals Income Trust, 225th Insured  Multi-Series
has duly caused this Registration Statement to be signed on its behalf by
the  undersigned, thereunto duly authorized in the City  of  Chicago  and
State of Illinois on the 30th day of September, 1997.
                                    
                                    Insured Municipals Income Trust,
                                       225th Insured Multi-Series
                                                             (Registrant)
                                    
                                    By  Van Kampen American Capital
                                        Distributors, Inc.
                                                             (Depositor)
                                    
                                    
                                    By  Gina Costello
                                        Assistant Secretary
     
     Pursuant  to  the requirements of the Securities Act of  1933,  this
Registration Statement has been signed below on September 30, 1997 by the
following persons who constitute a majority of the Board of Directors  of
Van Kampen American Capital Distributors, Inc.

 Signature               Title

Don G. Powell        Chairman and Chief            )
                     Executive Officer             )

William R. Molinari  President and Chief           )
                     Operating Officer             )

Ronald A. Nyberg     Executive Vice President      )
                     and General Counsel

William R. Rybak     Executive Vice President and  )
                     Chief Financial Officer       )

                                               By  Gina Costello
                                             (Attorney-in-fact*)
_________________________________________________________________________

* An  executed copy of each of the related powers of attorney  was  filed
  with  the  Securities  and Exchange Commission in connection  with  the
  Registration  Statement  on  Form S-6 of Van  Kampen  American  Capital
  Equity Opportunity Trust, Series 64 (File No. 333-33087).


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