INSURED MUNICIPALS INC TR & INV QUAL TAX EX TR MULTI SER 216
497, 1994-03-18
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                              Chapman and Cutler
                            111 West Monroe Street
                           Chicago, Illinois  60603



                                           March 18, 1994



Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549-1004

Attn:Filing Desk, Stop 1-4

                    Re:  Insured Municipals Income Trust and
                           Investors' Quality Tax-Exempt
                              Trust, Multi-Series 216
                        File No. 33-51927    CIK No. 896679

Ladies/Gentlemen:

     Pursuant to the requirements of Rule 497(d) of the General Rules and
Regulations of the Securities Act of 1933, we are submitting one copy of the
supplement, in the form of a sticker, to the prospectus being used with
respect to the above-captioned series.

                                          Very truly yours,

                                          CHAPMAN AND CUTLER

Enclosures
                      Insured Municipals Income Trust and
            Investors' Quality Tax-Exempt Trust, Multi-Series 216



             Supplement To The Prospectus Dated March 10,1994



In addition to the information in the section entitled "Unitholder 
Explanations" the following information should be included on page 16 of the 
prospectus:



 PURCHASED AND ACCRUED INTEREST 
     PURCHASED INTEREST. Purchased Interest is a portion of the unpaid 
interest that has accrued on the Securities from the later of the last 
payment date on the Securities or the date of issuance thereof through
the First Settlement Date and is included in the calculation of 
the Public Offering Price. Purchased Interest will be distributed to 
Unitholders as Units are redeemed or Securities mature or are called. See 
"Summary of Essential Financial Information" for the amount of Purchased 
Interest per Unit for each Trust. Purchased Interest is an element 
of the price Unitholders will receive in connection with the sale or 
redemption of Units prior to the termination of the Trust.     

     ACCRUED INTEREST. Accrued Interest is an accumulation of unpaid interest 
on securities which generally is paid semi-annually, although the Trust
accrues such interest daily. Because of this, the Trust always has 
an amount of Interest earned but not yet collected by the Trustee. For
this reason, with respect to sales settling subsequent to the First 
Settlement Date, the Public Offering Price of Units will have added to 
it the proportionate share of accrued interest to the date of settlement.
Unitholders will receive on the next distribution date of the Trust 
the amount, if any, of accrued interest paid on their Units.   

     As indicated in "Purchased Interest", accrued interest as of the First 
Settlement Date includes Purchased
Interest. In an effort to reduce the amount 
of Purchased Interest which would otherwise have to be paid by 
Unitholders, the Trustee may advance a portion of such accrued interest 
to the Sponsor as the Unitholder of record as of the First Settlement 
Date. Consequently, the amount of accrued interest to be added to the 
Public Offering Price of Units will include only accrued interest from 
the First Settlement Date to the date of settlement (other than the 
Purchased Interest already included therein), less any distributions 
from the Interest Account subsequent to the First Settlement Date. 
See "Public Offering-Distributions of Interest and Principal."      

     Because of the varying interest payment dates of the Securities, accrued 
interest at any point in time will be greater than the amount of interest 
actually received by a Trust and distributed to Unitholders. If a Unitholder 
sells or redeems all or a portion of his
Units, he will be entitled to receive 
his proportionate share of the Purchased Interest and accrued interest from 
the purchaser of his Units. Since the Trustee has the use of the funds 
(including Purchased Interest) held in the Interest Account for distributions 
to Unitholders and since such Account is non-interest-bearing to Unitholders, 
the Trustee benefits thereby.





Supplement Dated March 18,1994 


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