VAN KAMPEN AMERICAN CAPITAL INSURED INCOME TRUST SER 72
S-6, 1998-09-15
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FILE NO. 333-
CIK #897185

                   SECURITIES AND EXCHANGE COMMISSION
                      Washington, D.C.  20549-1004
                                Form S-6

For Registration under the Securities Act of 1933 of Securities of Unit
Investment Trust Registered on Form N-8B-2.

A. Exact name of Trust:  VAN KAMPEN INSURED INCOME TRUST, SERIES 72

B. Name of Depositor:    VAN KAMPEN FUNDS INC.

C. Complete address of Depositor's principal executive offices:

   One Parkview Plaza
   Oakbrook Terrace, Illinois  60181

D. Name and complete address of agents for service:

   VAN KAMPEN FUNDS INC.                CHAPMAN AND CUTLER
   Attention:  Don G. Powell, Chairman  Attention:  Mark J. Kneedy
   One Parkview Plaza                   111 West Monroe Street
   Oakbrook Terrace, Illinois  60181    Chicago, Illinois  60603

E. Title of securities being registered undivided beneficial interest:  Units of
   fractional

F. Approximate date of proposed sale to the public:
   
             AS SOON AS PRACTICABLE AFTER THE EFFECTIVE DATE
                      OF THE REGISTRATION STATEMENT

The registrant hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the
registrant shall file a further amendment which specifically states that
this Registration Statement shall thereafter become effective in
accordance with Section 8(a) of the Securities Act of 1933 or until the
Registration Statement shall become effective on such date as the
Commission, acting pursuant to said Section 8(a) may determine.

                   Van Kampen Insured Income Trust, Series 72
                              Cross Reference Sheet

                     Pursuant to Rule 404(c) of Regulation C
                        under the Securities Act of 1933

                   (Form N-8B-2 Items Required by Instruction
                         1 as to Prospectus on Form S-6)

Form N-8B-2                                                             Form S-6
Item Number                                                Heading in Prospectus

                I.  Organization and General Information

 1. (a)  Name of trust                   )

    (b)  Title of securities issued      ) Prospectus Front Cover Page

 2. Name and address of Depositor        ) Summary of Essential Financial
                                         ) Information
                                         ) Trust Administration

 3. Name and address of Trustee          ) Summary of Essential Financial
                                         ) Information
                                         ) Trust Administration

 4. Name and address of principal        ) Underwriting
      underwriter

 5. Organization of trust                ) The Trust

 6. Execution and termination of         ) The Trust
      Trust Indenture and Agreement      ) Trust Administration

 7. Changes of Name                      ) *

 8. Fiscal year                          ) *

 9. Material Litigation                  ) *

        II. General Description of the Trust and Securities of the Trust

10. General information regarding        ) The Trust
      trust's securities and rights of   ) Insurance on the Bonds
      security holders                   ) Tax Status
                                         ) Public Offering
                                         ) Rights of Unitholders
                                         ) Trust Administration

11. Type of securities comprising units  ) Prospectus Front Cover Page
                                         ) The Trust
                                         ) Trust Portfolio
                                         ) Trust Portfolio

12. Certain information regarding        ) *
      periodic payment certificates      )

13. (a)  Loan, fees, charges and expenses) Prospectus Front Cover Page
                                         ) Summary of Essential Financial
                                         ) Information
                                         ) Trust Portfolio
                                         ) Annual Unit Income and
                                         ) Estimated Current Returns
                                         ) Trust Operating Expenses
                                         ) Public Offering
                                         ) Rights of Unitholders

    (b)  Certain information regarding   ) *
           periodic payment plan         )
           certificates                  )

    (c)  Certain percentages             ) Prospectus Front Cover Page
                                         ) Summary of Essential Financial
                                         ) Information
                                         ) Annual Unit Income and
                                         ) Estimated Current Returns
                                         ) Insurance on the Bonds
                                         ) Public Offering
                                         ) Rights of Unitholders

    (d)  Certain other fees, expenses or ) Trust Operating Expenses
           charges payable by holders    ) Rights of Unitholders

    (e)  Certain profits to be received  ) Public Offering
           by depositor, principal       ) Underwriting
           underwriter, trustee or any   ) Trust Portfolio
           affiliated persons            )

    (f)  Ratio of annual charges         ) *
           to income                     )

14. Issuance of trust's securities       ) Rights of Unitholders

15. Receipt and handling of payments     )*
      from purchasers                    )

16. Acquisition and disposition of       ) The Trust
      underlying securities              ) Rights of Unitholders
                                         ) Trust Administration

17. Withdrawal or redemption             ) Rights of Unitholders
                                         ) Trust Administration

18. (a)  Receipt and disposition         ) Prospectus Front Cover Page
           of income                     ) Rights of Unitholders

    (b)  Reinvestment of distributions   ) *

    (c)  Reserves or special funds       ) Trust Operating Expenses
                                         ) Rights of Unitholders

    (d)  Schedule of distributions       ) *

19. Records, accounts and reports        ) Rights of Unitholders
                                         ) Trust Administration

20. Certain miscellaneous provisions     ) Trust Administration
      of Trust Agreement                 )

21. Loans to security holders           )  *

22. Limitations on liability             ) Trust Portfolio
                                         ) Trust Administration

23. Bonding arrangements                 ) *

24. Other material provisions of         ) *
    Trust Indenture Agreement            )

        III. Organization, Personnel and Affiliated Persons of Depositor

25. Organization of Depositor           ) Trust Administration

26. Fees received by Depositor          ) *

27. Business of Depositor               ) Trust Administration

28. Certain information as to           ) *
      officials and affiliated          )
      persons of Depositor              )

29. Companies owning securities         ) *
      of Depositor                      )

30. Controlling persons of Depositor    ) *

31. Compensation of Officers of         ) *
      Depositor                         )

32. Compensation of Directors           ) *

33. Compensation to Employees           ) *

34. Compensation to other persons       ) *

                  IV. Distribution and Redemption of Securities

35. Distribution of trust's securities  ) Public Offering
      by states                         )

36. Suspension of sales of trust's      )   *
      securities                        )

37. Revocation of authority to          ) *
      distribute                        )

38. (a)  Method of distribution         )

    (b)  Underwriting agreements        ) Public Offering

    (c)  Selling agreements             )

39. (a)  Organization of principal      )
           underwriter                  )

    (b)  N.A.S.D. membership by         )
           principal underwriter        )

40. Certain fees received by            ) *
      principal underwriter             )

41. (a)  Business of principal          ) Trust Administration
           underwriter                  )
    (b)  Branch offices or principal    ) *
           underwriter                  )

    (c)  Salesmen or principal          ) *
           underwriter                  )

42. Ownership of securities of          ) *
      the trust                         )

43. Certain brokerage commissions       ) *
      received by principal underwriter )

44. (a)  Method of valuation            ) Prospectus Front Cover Page
                                        ) Summary of Essential Financial
                                        ) Information
                                        ) Trust Operating Expenses
                                        ) Public Offering

    (b)  Schedule as to offering price  ) *

    (c)  Variation in offering price    ) *
           to certain persons           )

45. Suspension of redemption rights     ) *

46. (a)  Redemption valuation           ) Rights of Unitholders
                                        ) Trust Administration

    (b)  Schedule as to redemption price) *

47. Purchase and sale of interests      ) Public Offering
      in underlying securities          ) Trust Administration

               V. Information Concerning the Trustee or Custodian

48. Organization and regulation of      ) Trust Administration
      Trustee                           )

49. Fees and expenses of Trustee        ) Summary of Essential Financial
                                        ) Information
                                        ) Trust Operating Expenses
50. Trustee's lien                      ) Trust Operating Expenses


     VI.  Information Concerning Insurance of Holders of Securities

51. Insurance of holders of trust's     ) Cover Page
      securities                        ) Trust Operating Expenses
                                        ) Insurance on the Obligations

                            VII. Policy of Registrant

52. (a)  Provisions of trust agree-     ) Trust Administration
           ment with respect to         )
           replacement or elimination   )
           portfolio securities         )

    (b)  Transactions involving         )   *
           elimination of underlying    )
           securities                   )

    (c)  Policy regarding substitu-     ) Trust Administration
           tion or elimination of       )
           underlying securities        )

    (d)  Fundamental policy not         ) *
           otherwise covered            )

53. Tax Status of trust                 ) Tax Status

                   VIII. Financial and Statistical Information

54. Trust's securities during           ) *
      last ten years                    )

55.)
56.)  Certain information regarding     ) *
57.)  periodic payment certificates     )
58.)

59. Financial statements (Instructions  ) Report of Independent Certified
    1(c) to Form S-6)                   ) Public Accountants
                                        ) Statement of Condition

______________________________________________
* Inapplicable, omitted, answer negative or not required
                                    
             Preliminary Prospectus Dated September 15, 1998
                                    
                     Van Kampen Insured Income Trust
                                    
                                                             Series 72
                                             (A Unit Investment Trust)
     
     The  attached  final Prospectus for a prior Series of  the  Fund  is
hereby used as a preliminary Prospectus for the above stated Series.  The
narrative information and structure of the attached final Prospectus will
be  substantially  the  same  as that of the final  Prospectus  for  this
Series.  Information with respect to pricing, the number of Units,  dates
and summary information regarding the characteristics of securities to be
deposited in this Series is not now available and will be different since
each   Series  has  a  unique  Portfolio.   Accordingly  the  information
contained  herein with regard to the previous Series should be considered
as  being  included  for informational purposes  only.   Ratings  of  the
securities in this Series are expected to be comparable to those  of  the
securities  deposited  in the previous Series.   However,  the  Estimated
Current  Return  for  this Series will depend on the interest  rates  and
offering  prices of the securities in this Series and may vary materially
from that of the previous Series.
     
     A  registration statement relating to the units of this Series  will
be  filed  with the Securities and Exchange Commission but  has  not  yet
become  effective.  Information contained herein is subject to completion
or  amendment.   Such  Units may not be sold nor  may  offer  to  buy  be
accepted  prior to the time the registration statement becomes effective.
This Prospectus shall not constitute an offer to sell or the solicitation
of  an offer to buy nor shall there be any sale of the Units in any state
in  which  such  offer, solicitation or sale would be unlawful  prior  to
registration  or  qualification under the securities  laws  of  any  such
state.

(Incorporated herein by reference is the final prospectus from Van Kampen
American  Capital Insured Income Trust, Series 71 (Registration No.  333-
47923)  as  filed on March 20, 1998, which shall be used as a preliminary
prospectus for the current Series of the Fund.)

                   Contents Of Registration Statement

This Registration Statement comprises the following papers and documents:

    The facing sheet
    The Cross-Reference Sheet
    The Prospectus
    The signatures
    The consents of independent public accountants, rating services
      and legal counsel

The following exhibits:

1.1 Proposed form of Trust Agreement between Van Kampen Funds Inc.,
    Depositor, American Portfolio Advisory Service, a division of Van
    Kampen Investment Advisory Corp., as Evaluator, and The Bank of New
    York, as Trustee (to be supplied by amendment).

1.4 Copy of Bond Fund Portfolio Insurance Policy (to be supplied by
    amendment).

1.5 Form of Agreement Among Underwriters (to be supplied by amendment).

3.1 Opinion and consent of counsel as to legality of securities being
    registered (to be supplied by amendment).

3.2 Opinion of counsel as to Federal income tax status of securities
    being registered (to be supplied by amendment).

3.3 Opinion and consent of counsel as to New York tax status of
    securities being registered (to be supplied by amendment).

4.1 Consent of Interactive Data Corporation (to be supplied by
    amendment).

4.2 Consent of Standard & Poor's Corporation (to be supplied by
    amendment).

4.3 Consent of Grant Thornton LLP (to be supplied by amendment).

                               Signatures

     Pursuant  to  the requirements of the Securities Act  of  1933,  the
Registrant,  Van Kampen Insured Income Trust, Series 72 has  duly  caused
this   Registration  Statement  to  be  signed  on  its  behalf  by   the
undersigned, thereunto duly authorized in the City of Chicago  and  State
of Illinois on the 15th day of September, 1998.

                                    Van Kampen Insured Income Trust, Series 72
                                    
                                    By  Van Kampen Funds Inc.
                                        (Depositor)
                                    
                                    By  Gina M. Costello
                                        Assistant Secretary
     
     Pursuant  to  the requirements of the Securities Act of  1933,  this
Registration Statement has been signed below on September 15, 1998 by the
following persons who constitute a majority of the Board of Directors  of
Van Kampen Funds Inc.

Signature           Title

Don G. Powell       Chairman and Chief            )
                    Executive Officer             )

John H. Zimmerman   President and Chief           )
                    Operating Officer             )

Ronald A. Nyberg    Executive Vice President      )
                    and General Counsel           )

William R. Rybak    Executive Vice President and  )
                      Chief Financial Officer     )

                    Gina M. Costello              ) (Attorney-in-fact*)
_________________________________________________________________________
*An  executed  copy of each of the related powers of attorney  was  filed
with  the  Securities  and Exchange Commission  in  connection  with  the
Registration Statement on Form S-6 of Van Kampen American Capital  Equity
Opportunity,  Series  64  (File No. 33-33087)  and  Van  Kampen  American
Capital  Equity Opportunity, Series 87 (File No. 33-44581) and  the  same
are hereby incorporated herein by this reference.


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