PAPPAJOHN JOHN
SC 13D/A, 2000-05-08
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.   20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934
Amendment No. 1

PATIENT INFOSYSTEMS, INC.
(Name of Issuer)

Common Stock
$.01 Par Value Per Share
(Title Class of Securities)

878190115
(CUSIP Number)

Mr. John Pappajohn
2116 Financial Center
Des Moines, Iowa 50309
515-244-5746
(Name, Address and Telephone Number of Person Authorized to
 Receive Notices and Communications)

March 31, 2000
(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule
13G to report the acquisition which is the subject of this
Schedule 13D, and is filing this schedule because of Rule
13d-1(b)(3) or (4), check the following box:  /  /

Check the following box if a fee is being paid with this
statement: /  /


(1)    NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       John Pappajohn  ###-##-####

(2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

       (a)  /  /
       (b)  /  /

(3)    SEC USE ONLY

(4)    SOURCE OF FUNDS

       PF

(5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
       PURSUANT TO ITEMS 2(d) OR 2(e)

       /   /

(6)    CITIZENSHIP OR PLACE OR ORGANIZATION

       U.S.A.

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING
PERSON WITH:

(7)    SOLE VOTING POWER

       2,313,780

(8)    SHARED VOTING POWER

       0

(9)    SOLE DISPOSITIVE POWER

       2,313,780

(10)   SHARED DISPOSITIVE POWER

       0

(11)   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
       PERSON

       2,313,780

(12)   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       CERTAIN SHARES

       /  /

(13)   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

       26.32%

(14)   TYPE OF REPORTING PERSON

       IN


SCHEDULE 13D

This amends and supplements the Statement on Schedule 13D filed
with the Commission by John Pappajohn ("Pappajohn") with
respect to his ownership of Common Stock (the "Common Stock"), $.01
par value per share, Convertible Preferred Stock, Series C, no par
value per share ("Series C Preferred Stock"), Warrants to
purchase shares of Common Stock (the "Warrants") and Options to
purchase shares of Common Stock (the "Options")  of Patient
Infosystems, Inc., a Delaware Corporation (the "Company").
Unless otherwise defined herein, all capitalized items used herein
shall have the meaning ascribed to them in the Statement.


Item 5.     Interest in Securities of the Issuer

(a) As of the date of this statement, Mr. Pappajohn
beneficially owned 1,972,480 shares of Common Stock (assuming the
conversion of 50,000 shares of Series C Preferred Stock into 400,000
shares of Common Stock) and Warrants and Options to purchase another
341,300 shares of Common Stock. Such shares of Common Stock and
the Warrants and Options represent 26.32% of the Company's issued
and outstanding shares, assuming conversion of Pappajohn's Series C
Preferred Stock, Warrants, and Options into Common Stock. This
does not include 7,200 shares subject to outstanding Options which
are not exercisable within the next 60 days.

     (b)  Mr. Pappajohn has sole power to vote or direct the vote
and sole power to dispose or direct the disposition of all shares
of Common Stock and Series C Preferred Stock that he owns.

(b) On March 31, 2000, Mr. Pappajohn purchased 50,000 shares
of Series C Preferred Stock for $500,000. The shares of Series C
Preferred Stock are convertible into 400,000 shares of Common Stock.
In addition, Mr. Pappajohn was granted Warrants to purchase 187,500
and 125,000 shares of Common Stock on February 16, 2000 and March 23,
2000, respectively, in consideration of a personal guarantee on the
Company's Line of Credit.

     (d - e)  Not applicable.


Item 6.     Contracts, Arrangements, Understandings or
            Relationships with Respect to Securities of Issuer

     Not applicable.


Item 7.     Material to be Filed as Exhibits

     Not applicable.


Item 8.  Certification and Signature:

After reasonable inquiry and to the best of my knowledge and
belief, the undersigned certifies that the information set forth
in this Statement is true, complete and correct.

Dated: May 8, 2000

/s/ John Pappajohn
- -------------------
John Pappajohn



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