CAISSE DE DEPOT ET PLACEMENT DU QUEBEC
SC 13D, 2000-02-25
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*

                          CUBIST PHARMACEUTICALS, INC.
                                (Name of Issuer)

                          COMMON STOCK $.001 PAR VALUE
                         (Title of Class of Securities)

                                   229 678 610
                                 (CUSIP Number)

                                GINETTE DEPELTEAU
                                    SOFINOV,
                      SOCIETE FINANCIERE D'INNOVATION, INC.
                           1981 MCGILL COLLEGE AVENUE
                            MONTREAL, QUEBEC HCA 3C7
                                 (514) 847-5901

           (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                               [FEBRUARY 11, 2000]
             (Date of Event Which Requires Filing of This Statement)



If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rules 13d-1 (e), 13d-1(f) or 13d-1(g), check
the following box / /.

Note: Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits. See Rule 13d-7 for other
parties to whom copies are to be sent.
                         (Continued on following pages)

- -----------------
*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosure provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section
of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).


                                      1

<PAGE>

CUSIP No. 229 678 610
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
1.       NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         SOFINOV, SOCIETE FINANCIERE D'INNOVATION, INC.
- --------------------------------------------------------------------------------
2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                       (a) / /1
                                                                       (b) / /2
- --------------------------------------------------------------------------------
3.       SEC USE ONLY

- --------------------------------------------------------------------------------
4.       SOURCE OF FUNDS*: WC
- --------------------------------------------------------------------------------
5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) OR 2(e)                                                / /3
- --------------------------------------------------------------------------------
6.       CITIZENSHIP OR PLACE OF ORGANIZATION

         MONTREAL, QUEBEC, CANADA
- --------------------------------------------------------------------------------
NUMBER OF SHARES BENEFICIALLY     7.       SOLE VOTING POWER:
OWNED BY EACH REPORTING PERSON             2,597,335(1)
WITH
                                  ----------------------------------------------
                                  8.       SHARED VOTING POWER:
                                           --
                                  ----------------------------------------------
                                  9.       SOLE DISPOSITIVE POWER:
                                           2,597,335
                                  ----------------------------------------------
                                  10.      SHARED DISPOSITIVE POWER:
                                           --
- --------------------------------------------------------------------------------
11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,597,335
- --------------------------------------------------------------------------------
12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
                                                                          / /4
- --------------------------------------------------------------------------------
13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):

         9.72%
- --------------------------------------------------------------------------------
14.      TYPE OF REPORTING PERSON: CO
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
         (1)  Includes 1,111,112 shares of Common Stock of the Company
         issuable upon exercise of a warrant.  See Item 4 below.

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


                                      2

<PAGE>

CUSIP No. 229 678 610
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
1.       NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         CAISSE DE DEPOT ET PLACEMENT DU QUEBEC.
- --------------------------------------------------------------------------------
2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                       (a) / /5
                                                                       (b) / /6
- --------------------------------------------------------------------------------
3.       SEC USE ONLY

- --------------------------------------------------------------------------------
4.       SOURCE OF FUNDS*:  WC
- --------------------------------------------------------------------------------
5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) OR 2(e)                                               / /7
- --------------------------------------------------------------------------------
6.       CITIZENSHIP OR PLACE OF ORGANIZATION

         MONTREAL, QUEBEC, CANADA
- --------------------------------------------------------------------------------
NUMBER OF SHARES BENEFICIALLY     7.       SOLE VOTING POWER:
OWNED BY EACH REPORTING PERSON             2,597,335(1)
WITH
                                  ----------------------------------------------
                                  8.       SHARED VOTING POWER:
                                           --
                                  ----------------------------------------------
                                  9.       SOLE DISPOSITIVE POWER:
                                           2,597,335
                                  ----------------------------------------------
                                  10.      SHARED DISPOSITIVE POWER:
                                           --
- --------------------------------------------------------------------------------
11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,597,335
- --------------------------------------------------------------------------------
12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN  SHARES
                                                                          / / 8
- --------------------------------------------------------------------------------
13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):

                 9.72%
- --------------------------------------------------------------------------------
14.      TYPE OF REPORTING PERSON: CO
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
         (1)  Includes 1,111,112 shares of Common Stock of the Company
         issuable upon exercise of a warrant.  See Item 4 below.
                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


                                      3

<PAGE>

         This Amendment No. 3, dated February 11, 2000 is being filed jointly
on behalf of Caisse de depot et placement du Quebec ("CDPQ") and by its
wholly-owned subsidiary, SOFINOV, Societe financiere d'innovation, inc.
("Sofinov") pursuant to Rule 13d-2(a) under the Securities Exchange Act of
1934, as amended (the "Exchange Act") pursuant to a Joint Filing Agreement
dated February 11, 2000, between CDPQ and Sofinov, a copy of which is
attached hereto as Exhibit 1.

ITEM 1.  SECURITY AND ISSUER.

         This Schedule 13D relates to the Common Stock, par value $.001 per
         share ("Common Stock"), of Cubist Pharmaceuticals, Inc., a Delaware
         corporation (the "Company"). The address of the principal executive
         offices of the Company is 24 Emily Street, Cambridge, Massachusetts
         02139.

ITEM 2.  IDENTITY AND BACKGROUND

         This Schedule 13D is filed jointly on behalf of CDPQ, a corporation
         without share capital and an agent of the Crown in right of the
         Province de Quebec, created by a special act of the Legislature of the
         Province de Quebec, and Sofinov, a legal entity duly incorporated under
         part 1A of the Companies ACT (Quebec) and a wholly-owned subsidiary of
         CDPQ, pursuant to Rule 13d-1(f)(1) under the Exchange Act.

         The principal business address and the principal office address of each
         of CDPQ and Sofinov is 1981, Avenue McGill College, Suite 1330,
         Montreal, Quebec, H3A 3C7, Canada. The name, business address,
         citizenship and present principal occupation of each director and
         executive officer of CDPQ and Sofinov are set forth on Schedule I.

         To the best knowledge of CDPQ and Sofinov, none of the persons listed
         on Schedule I has, during the last five years, (i) been convicted in a
         criminal proceeding (excluding traffic violations or similar
         misdemeanors) or (ii) been a party to a civil proceeding of a judicial
         or administrative body of competent jurisdiction and as a result of
         such proceeding was or is subject to a judgment, decree or final order
         enjoining future violations of, or prohibiting or mandating activities
         subject to, United States federal or state securities laws or finding
         any violation with respect to such laws.


                                      4

<PAGE>

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

         All the funds required to purchase the Initial Shares (as defined
         below) were obtained from the working capital of Sofinov.

ITEM 4.  PURPOSE OF TRANSACTION

         Pursuant to a Purchase Agreement (the "Purchase Agreement") dated
         September 10, 1998, Sofinov acquired beneficial ownership of 3,497,335
         shares of Common Stock in a private placement through (i) the purchase
         of 2,386,223 shares of Common Stock (the "Initial Shares") and (ii) the
         granting by the Company to Sofinov of a warrant (the "Warrant")
         exercisable in whole or in part into 1,111,112 shares of Common Stock
         (the "Warrant Shares") with an expiration date of September 23, 2003.

         Pursuant to the exercise of certain registration rights granted to
         Sofinov in connection with the private placement, the Initial Shares
         and the Warrant Shares were registered for resale by Sofinov on a
         Registration Statement on Form S-3 which was filed with the SEC on
         September 30, 1998.

         Sofinov sold 400,000 Initial Shares for US$16,586,817 as set forth on
         Exhibit 2.

         Pursuant to the Purchase Agreement, Sofinov has the right to designate
         one person to be elected to the board of directors of the Company. The
         Company has agreed to take all steps necessary and appropriate and
         otherwise use its best efforts to cause the individual designated by
         Sofinov to be duly and properly elected to the board of directors of
         the Company. This right will terminate when Sofinov ceases to own at
         least thirty-three and one-third percent (33 1/3%) of the Initial
         Shares purchased by it under the Purchase Agreement.

         Except as specifically set forth in this Item 4, neither CDPQ nor
         Sofinov has any plans or proposals which relate to or would result in
         any of the actions or effects set forth in items (a) through (e) of
         Item 5 of Schedule 13D, although either of them may develop such plans
         or proposals.

         CDPQ and Sofinov intend to review on a continuing basis their
         investment in the Company. As of the date of this Schedule 13D, no
         determination has been made by CDPQ or Sofinov to acquire additional
         shares of Common Stock or dispose of any shares of Common Stock now
         held by them, although either of them may decide


                                      5

<PAGE>

         to so acquire or dispose of shares of Common Stock. Any such
         determination will depend on market conditions prevailing from time
         to time and on other conditions which may be applicable depending on
         the nature of the transaction or transactions involved.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER

   (a)   With recent transactions, Sofinov is the direct beneficial owner of
         2,597,335 shares of Common Stock (including the Warrant Shares)(the
         "Sofinov Shares"). CDPQ may be deemed to be the indirect, beneficial
         owner of the Sofinov Shares. The Sofinov Shares represent approximately
         9.72% of the 25,605,455 shares of Common Stock of the Company
         outstanding on the date hereof, based upon information provided by the
         company, plus the Warrant Shares.

   (b)   CDPQ has the power to vote and dispose of the Sofinov Shares.

   (c)   Except as set forth in this Schedule 13D, none of CDPQ, Sofinov or, to
         the best knowledge of CDPQ or Sofinov, any person named on Schedule I
         hereto, owns any shares of the Company's Common Stock, and none has
         purchased or sold any shares of the Company's Common Stock during the
         past 60 days.

   (d)   Except as set forth in this Schedule 13D, no person is known by CDPQ or
         Sofinov to have the right to receive or the power to direct the receipt
         of dividends from, or the proceeds from the sale of, the shares of
         Common Stock of the Company beneficially owned by CDPQ and Sofinov.

   (e)   Not applicable.

ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT
         TO SECURITIES OF THE ISSUER

         Except as set forth in this Schedule 13D, there are no contracts,
         arrangements, understandings or relationships (legal or otherwise)
         among the persons referred to in Item 2 of this Schedule 13D or between
         such persons and any other person with respect to any of the securities
         of the Company, including, but not limited to, any relating to the
         transfer or voting of any of such securities, finder's fees, joint
         ventures, loan or option arrangements, puts or calls, guarantees of
         profits, division of profits or loss or the giving or withholding of
         proxies.


                                      6

<PAGE>

ITEM 7.  MATERIALS TO BE FILED AS EXHIBITS

               1.   Joint Filing Agreement dated February 11, 2000 by and
                    between Sofinov and CDPQ.

               2.   Joint Filing Table of Dates, Number of Shares sold and price
                    per Share of Sales.


SIGNATURES


After reasonable inquiry and to the best knowledge and belief of the
undersigned, the undersigned certifies that the information set forth in this
statement is true, complete and correct.

Date:          February 11, 2000

                                SOFINOV, SOCIETE FINANCIERE D'INNOVATION, INC.



                                By:
                                    -------------------------------------------
                                        Name:  Ginette Depelteau
                                        Title: Corporate Secretary


                                CAISSE DE DEPOT ET PLACEMENT DU QUEBEC.



                                By:
                                    -------------------------------------------
                                        Name:  Ginette Depelteau
                                        Title: General Secretary - Director






                                      7

<PAGE>

                                   SCHEDULE I

               LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF SOFINOV

<TABLE>
<CAPTION>

DIRECTORS                      BUSINESS ADDRESS                                             PRINCIPAL OCCUPATION

<S>                            <C>                                                          <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec                       Chairman
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Line Boisvert                  Caisse de depot et placement du Quebec                       Director and
                               1981, Avenue McGill College                                  Portfolio Manager
                               Montreal (Quebec) H3A 3C7

Jacques M. Brault              Levesque Beaubien Geoffrion Inc.                             Senior
                               1155, Metcalfe, 5e etage                                     Vice-President
                               Montreal, (Qubec) H3B 4S9

Denis Dionne                   SOFINOV, Societe financiere d'innovation, inc.               President
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Claude Lajeunesse              Ryerson Polytechnic University                               President and Vice
                               350, Victoria Street                                         Chancellor
                               Toronto (Ontario) H2M 2V1

Serge Martin                   Martin International                                         President
                               500, Place d'Armes, Suite 2910
                               Montreal, (Qubec) H2Y 2W2

Guy Morneau                    Regie des rentes du Quebec                                   Chairman of the
                               2600 boul. Laurieir, bureau 546                              Board and President
                               Qubec (Qubec) G1V 4T3

Normand Provost                Caisse de depot et placement du Quebec                       Vice-President
                               1981, Avenue McGill College                                  Coordinator
                               Montreal (Quebec) H3A 3C7
</TABLE>




                                      8


<PAGE>

                                   SCHEDULE 1

               LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF SOFINOV

<TABLE>
<CAPTION>

OFFICERS                       BUSINESS ADDRESS                                             PRINCIPAL OCCUPATION

<S>                            <C>                                                          <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec                             Chairman
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Denis Dionne                   SOFINOV, Societe financiere d'innovation, inc.                    President
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Pierre Pharand                 SOFINOV, Societe financiere d'innovation, inc.                  Vice-President
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Bertrand Lauzon                Caisse de depot et placement du Quebec                         Vice-President,
                               1981, Avenue McGill College                                  Finance and Control
                               Montreal (Quebec) H3A 3C7

Ginette Depelteau              Caisse de depot et placement du Quebec                            Secretary
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7
</TABLE>


                                      9

<PAGE>



                                   SCHEDULE 1

                LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF CDPQ

<TABLE>
<CAPTION>

DIRECTORS                      BUSINESS ADDRESS                                      PRINCIPAL OCCUPATION
<S>                            <C>                                                   <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec                Chairman
                               1981, avenue McGill College
                               Montreal (Quebec) H3A 3C7

Guy Morneau                    Regie des rentes du Quebec                            Chairman of the Board
                               2600, boul. Laurier, bureau 546                       and President
                               Quebec (Quebec)  G1V 4T3

Jean-Claude Bachand            Byers Casgrain                                        Lawyer
                               1, Place Ville-Marie
                               Bureau 3900
                               Montreal (Quebec) H3B 4M7

Claude Beland                  La Confederation des Caisses populaires et            President
                               d'economie Desjardins du Quebec
                               100, avenue des Commandeurs
                               Levis (Quebec) G6V 7N5

Luc Bessette                   Commission administrative des regimes                 President
                               de retraite et d'assurances
                               475, rue Saint-Amable
                               Quebec (Quebec) G1R 5X3

Rodrigue Biron                 Rodrigue Biron & Associes
                               305, chemin de la Place St-Laurent
                               St-Augustin-de-Desmaures
                               Cap-Rouge (Quebec) G1Y 3G9

Yves Filion                    Hydro-Quebec                                          Deputy Chief
                               75, boul. Rene-Levesque Ouest                         Executive Officer
                               Montreal (Quebec)                                     and Chief Financial
                               H2Z 1A4                                               Officer

Jean-Yves Gagnon               Societe de l'assurance automobile du Quebec           General Manager
                               333, boul. Jean-Lesage
                               Quebec (Quebec) G1K 8J6

Henri Masse                    Federation des travailleurs et travailleuses du       President
                               Quebec
                               545, boul. Cremazie Est, 17e etage
                               Montreal, (Quebec) H2M 2V1
</TABLE>


                                      10

<PAGE>

                                   SCHEDULE 1

                LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF CDPQ

<TABLE>
<CAPTION>

DIRECTORS                      BUSINESS ADDRESS                                      PRINCIPAL OCCUPATION
<S>                            <C>                                                   <C>
Gilles Godbout                 Ministere des Finances                                Deputy Minister
                               12, rue St-Louis
                               Quebec (Quebec) G1R 5L3

Thomas O. Hecht                Technologies IBEX Inc.                                Chairman Emeritus
                               5485, rue Pare
                               Montreal (Quebec)  H4P 1P7

Marc Laviolette                Confederation des syndicats nationaux                 President
                               1601, rue Delorimier
                               Montreal (Quebec) H2K 4M5

Nicole Trudeau                 Commission municipale du Quebec                       Vice-President
                               2, Complexe Desjardins
                               Suite 3100, East Tower
                               Montreal (Quebec) H5B 1B2
</TABLE>


                                      11

<PAGE>

                                   SCHEDULE 1

                LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF CDPQ

<TABLE>
<CAPTION>

OFFICERS                       BUSINESS ADDRESS                               PRINCIPAL OCCUPATION
<S>                            <C>                                            <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec         Chairman
                               1981, avenue McGill College
                               Montreal (Quebec) H3A 3C7

Fernand Perreault              Same                                           Senior Vice-president
                                                                              Caisse Real Estate Group
                                                                              and Mortgage Investments

Michel Nadeau                  Same                                           Senior Vice-president
                                                                              Investment Planning and
                                                                              Strategic Affairs

Ginette Depelteau              Same                                           General  Secretary -
                                                                              Director
</TABLE>


                                      12

<PAGE>

                                  EXHIBIT INDEX

EXHIBIT

1.   Joint Filing Agreement dated February 11, 2000 by and between Sofinov and
     CDPQ.

2.   Joint Filing Table of Dates, Number of Shares sold and price per Share of
     Sales.








                                      13

<PAGE>

                                    EXHIBIT 1


                                    AGREEMENT


         The undersigned hereby agree that this statement on Schedule 13D
with respect to beneficial ownership of shares of common stock of Cubist
Pharmaceuticals, Inc. is filed jointly, on behalf of each of them.


Dated:   February 11, 2000


                              SOFINOV, SOCIETE FINANCIERE D'INNOVATION, INC.


                              By:
                                  ---------------------------------------------
                                    Name:  Denis Dionne
                                    Title: President


                              By:
                                  ---------------------------------------------
                                    Name:  Ginette Depelteau
                                    Title: Corporate Secretary


                              CAISSE DE DEPOT ET PLACEMENT DU QUEBEC.


                              By:
                                  ---------------------------------------------
                                    Name:  Michel Nadeau
                                    Title: Senior Vice-president
                                           Investment Planning and Strategic
                                           Affairs


                              By:
                                  ---------------------------------------------
                                    Name:  Ginette Depelteau
                                    Title: General Secretary - Director


                                      14

<PAGE>

                                    EXHIBIT 2

- --------------------------------------------------------------------------------
                                TABLE OF SALES OF
                          CUBIST PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------


                                      SALES
- --------------------------------------------------------------------------------
<TABLE>
<CAPTION>
                                                               PRICE PER SHARE
DATE                             NUMBER OF SHARES               IN CDN DOLLARS
- ----                             ----------------               --------------
<S>                              <C>                           <C>
February

        01                              25,000                      35.31  *
        02                             115,000                      36.78  *
        03                              30,000                      38.12  *
        04                              25,000                      40.12  *
        07                              75,000                      46.65  *
        08                              40,000                      46.28  *
        10                              75,000                      43.67  *
        11                              15,000                      46.87  *
</TABLE>


*   Sales effected in United States






                                      15



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