RENAL TREATMENT CENTERS INC /DE/
424B3, 1997-11-21
SPECIALTY OUTPATIENT FACILITIES, NEC
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                    SUPPLEMENT NO. 12 DATED NOVEMBER 21, 1997
                      TO PROSPECTUS DATED SEPTEMBER 3, 1996
          RELATING TO $125,000,000 PRINCIPAL AMOUNT 5-5/8% CONVERTIBLE
                         SUBORDINATED NOTES DUE 2006 AND
                               3,654,971 SHARES OF
                          RENAL TREATMENT CENTERS, INC.
                          COMMON STOCK, $.01 PAR VALUE


     All capitalized terms used but not defined herein shall have the meanings
prescribed in the Prospectus dated September 3, 1996, as supplemented by
Supplement No. 1 dated December 2, 1996, Supplement No. 2 dated December 9,
1996, Supplement No. 3 dated January 6, 1997, Supplement No. 4 dated January 13,
1997, Supplement No. 5 dated February 18, 1997, Supplement No. 6 dated March 17,
1997, Supplement No. 7 dated April 30, 1997, Supplement No. 8 dated May 9, 1997,
Supplement No. 9 dated May 12, 1997, Supplement No. 10 dated June 27, 1997 and
Supplement No. 11 dated August 21, 1997, forming a part of Form S-3 Registration
Statement No. 333-10839.

     The purpose of this supplement is to provide additional information
regarding the Selling Securityholders. The Selling Securityholders in the table
below are identified by this supplement. The Notes beneficially owned by these
Selling Securityholders were previously listed in the Prospectus under the names
of the nominee or Depository Trust Company participant holding the Notes for the
benefit of the Selling Securityholders or the persons from whom the Selling
Securityholders purchased the Notes. The table has been prepared based upon
information furnished to the Company by or on behalf of the Selling
Securityholders identified therein.


<TABLE>
<CAPTION>
                                                 Principal Amount of                      Number of
                                                 Notes Beneficially                      Conversion
                                                       Owned             Percentage         Shares           Percentage  
                                                      That May            of Notes         That May       of Common Stock
Name                                                 Be Sold ($)         Outstanding      Be Sold (1)      Outstanding (2)
- ----                                                 -----------         -----------      -----------      ---------------
<S>                                                    <C>                <C>              <C>              <C> 
Declaration of Trust for the Defined                   530,000               *              15,497               *
Benefit Plan of ICI American Holdings, Inc.                                                                 
                                                                                                            
Declaration of Trust for the Defined                   345,000               *              10,087               *
Benefit Plan of Zeneca Holdings, Inc.                                                                       
                                                                                                            
Delaware State Employees Retirement Fund             1,655,000               1.3%           48,391               *
                                                                                                            
General Motors Employees Domestic Group              7,550,000               6.0%          220,760               *
Trust                                                                                                       
                                                                                                            
Hillside Capital Incorporated Corporate                160,000               *               4,678               *
Account                                                                                                     
                                                                                                            
                                                                                                            
<PAGE>
                                                                                                            
                                                                                                            
                                                                                                            
Thermo Electron Balanced Investment Fund               300,000               *               8,771               *
</TABLE>


* Less than 1%.

(1)  Assumes conversion of the full amount of Notes held by such holder at the
     current conversion rate of $34.20 in principal amount of Notes per share of
     Common Stock. Under the terms of the Indenture, fractional shares will not
     be issued upon conversion of the Notes; cash will be paid in lieu of
     fractional shares, if any.

(2)  Computed in accordance with Rule 13d-3(d)(i) promulgated under the Exchange
     Act based upon the 24,991,807 shares of Common Stock outstanding as of
     November 10, 1997, treating as outstanding the number of Conversion Shares
     shown as being issuable upon the assumed conversion by the named holder of
     the full amount of such holder's Notes but not assuming the conversion of
     the Notes of any other holders.

     Other than their ownership of the Company's securities, none of the
foregoing Selling Securityholders has had any material relationship with the
Company within the past three years.





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