<PAGE> 1
----------------------------
OMB APPROVAL
OMB Number: 3235-0145
Expires: December 31, 1997
Estimated average burden
hours per response. . .14.90
----------------------------
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(AMENDMENT)*
Alexion Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock ($.0001 par value)
- --------------------------------------------------------------------------------
(Title of Class of Securities)
015351109
------------------------------
(CUSIP Number)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
<PAGE> 2
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 2 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON BIOTECHNOLOGY INVESTMENT GROUP, LLC ("BIO")
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
-0-
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 891,898
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH -0-
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
891,898
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
891,898
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
00
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 3
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 3 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON EDWARD BLECH TRUST ("EBT")
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a)[ ]
(b)[ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
New York
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
-0-
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 891,898
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH -0-
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
891,898
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
891,898
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
OO
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 4
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 4 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON COLLINSON HOWE VENTURE PARTNERS, INC.
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
-0-
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 891,898
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH -0-
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
891,898
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
891,898
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
CO
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 5
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 5 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON SCHRODERS INCORPORATED ("SI")
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
-0-
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 891,898
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH -0-
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
891,898
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
891,898
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
CO
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 6
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 6 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON JEFFREY J. COLLINSON ("JJC")
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
7,131
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 899,029
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 7,131
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
899,029
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
899,029
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 7
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 7 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON SCHRODER VENTURES U.S. TRUST ("SVUST")
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Bermuda
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
-0-
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 891,898
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH -0-
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
891,898
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
891,898
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
OO
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 8
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 8 OF 17
--------- --- ----
- ------------------------- ------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON SCHRODER VENTURES LIMITED PARTNERSHIP ("SVLP")
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
-0-
NUMBER OF -------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 891,898
EACH -------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH -0-
-------------------------------------------------------
8 SHARED DISPOSITIVE POWER
891,898
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
891,898
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
12.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE> 9
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 9 OF 17
--------- --- ----
- ------------------------- ------------------------------
ITEM 1(a). NAME OF ISSUER: Alexion Pharmaceuticals, Inc.
---------------
ITEM 1(b). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
------------------------------------------------
25 Science Park
New Haven, CT 06511
ITEM 2. NAMES, ADDRESSES AND CITIZENSHIP OF PERSONS FILING:
--------------------------------------------------
I. For Reporting Person
--------------------
BIOTECHNOLOGY INVESTMENT GROUP, L.L.C.:
a) Biotechnology Investment Group, L.L.C.
b) c/o Collinson Howe Venture Partners, Inc.
1055 Washington Boulevard
Stamford, CT 06901
c) Place of organization -- Delaware
II. REGARDING REPORTING PERSON EDWARD BLECH TRUST:
a) Edward Blech Trust
b) 418 Avenue I
Brooklyn, NY 11231
c) Trusted created under laws of New York
REGARDING REPORTING PERSON COLLINSON HOWE VENTURE PARTNERS, INC.
a) Collinson Howe Venture Partners, Inc.
b) 1055 Washington Boulevard
Stamford, CT 06901
c) Place of Organization - Delaware
REGARDING REPORTING PERSON:
a) Schroders Incorporated
b) 787 Seventh Avenue, 29th Floor
New York, NY 10019
c) Place of Organization -- Delaware
<PAGE> 10
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 10 OF 17
--------- ---- ----
- ------------------------- ------------------------------
REGARDING REPORTING PERSON JEFFREY J. COLLINSON:
a) Jeffrey J. Collinson
b) 1055 Washington Boulevard,
Stamford, CT 06901
c) Citizenship - United States
REGARDING REPORTING PERSON SCHRODER VENTURES US TRUST:
a) Schroder Ventures U.S. Trust
b) c/o Schroder Venture Managers Limited
22 Church Street
Hamilton HM 11, Bermuda
c) SVUST is a closed-end unit trust created under the laws of
Bermuda
REGARDING REPORTING PERSON SCHRODER VENTURES LIMITED PARTNERSHIP:
a) Schroder Ventures Limited Partnership
b) c/o Schroder Ventures Management L.P.
787 Seventh Avenue
29th Floor
New York, NY 10019
c) Place of organization -- Delaware
ITEM 2(d). TITLE OF CLASS OF SECURITIES: Common Stock
-----------------------------
ITEM 2(e). CUSIP NUMBER: N/A
-------------
ITEM 3. IF THIS STATEMENT IF FILED PURSUANT TO RULES
--------------------------------------------
13D-1(b), or 13D-2(b), CHECK WHETHER THE PERSON FILING IS A:
------------------------------------------------------------
(a) [ ] Broker or Dealer registered under Section 15 of the
Act,
(b) [ ] Bank as defined in Section 3(a)(6) of the Act,
(c) [ ] Insurance Company as defined in Section 3(a)(19) of
the Act,
(d) [ ] Investment Company registered under Section 8 of
the Investment Company Act,
(e) [ ] Investment Advisor registered under Section 203 of
the Investment Advisors Act of 1940,
(f) [ ] Employee Benefit Plan, Pension Fund which
is subject to the provisions of the Employee
Retirement Income Security Act of 1974 or
Endowment Fund; see Rule 13d-1(b)(1)(ii)(f)
of the Act,
(g) [ ] Parent Holding Company, in accordance with Rule
13d-1(b)(ii)(G); see Item 7,
<PAGE> 11
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 11 OF 17
--------- ---- ----
- ------------------------- ------------------------------
(h) [ ] Group, in accordance with Rule 13d-1(b)(l)(ii)(H).
Not Applicable.
ITEM 4. OWNERSHIP.
---------
See Items 5-8 on cover pages.
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
--------------------------------------------
Not Applicable.
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
--------------------------------------------------------
PERSON.
------
Not Applicable.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
---------------------------------------------------------
ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
-------------------------------------------------------------
COMPANY.
-------
Not Applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
----------------------------------------------------------
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP.
-------------------------------
Not Applicable.
ITEM 10. CERTIFICATION.
--------------
Not Applicable. This statement on Schedule 13G is not filed
pursuant to Rule 13d-1(b).
<PAGE> 12
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 12 OF 17
--------- ---- ----
- ------------------------- ------------------------------
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
February 28, 1997 BIOTECHNOLOGY INVESTMENT GROUP, L.L.C.
----------------- By: COLLINSON HOWE VENTURE PARTNERS, INC.
Date Its: Managing Member
By: *
--------------------------------------------
Jeffrey J. Collinson, President
EDWARD BLECH TRUST
By: *
--------------------------------------------
Mordechai Jofen, as Sole Trustee
COLLINSON HOWE VENTURE PARTNERS, INC.
By: *
--------------------------------------------
Jeffrey J. Collinson, President
*
-----------------------------------------------
JEFFREY J. COLLINSON
SCHRODERS INCORPORATED
By: *
--------------------------------------------
Jeffrey J. Collinson, Its Attorney-in-Fact
SCHRODER VENTURES U.S. TRUST
By: SCHRODER VENTURE MANAGERS LIMITED
Its: Manager
By: *
--------------------------------------------
<PAGE> 13
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 13 OF 17
--------- ---- ----
- ------------------------- ------------------------------
SCHRODER VENTURES LIMITED
PARTNERSHIP
By: SCHRODER VENTURES MANAGEMENT L.P.
Its: General Partner
By: SCHRODER VENTURE MANAGERS INC.
Its: General Partner
By: *
--------------------------------------------
* By: /s/Timothy C. Maguire
--------------------------------------------
Timothy C. Maguire, Attorney-in-Fact
<PAGE> 14
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 14 OF 17
--------- ---- ----
- ------------------------- ------------------------------
EXHIBIT 1
---------
AGREEMENT
---------
Pursuant to Rule 13d-1(f)(1) under the Securities Exchange Act of 1934, the
undersigned hereby agree that only one statement containing the information
required by Schedule 13G need be filed on behalf of all of the undersigned with
respect to the ownership of shares of Common Stock of Alexion Pharmaceuticals,
Inc. by any of the undersigned.
This agreement may be executed in any number of counterparts, each of which
shall be deemed an original.
EXECUTED as a sealed instrument this 28th day of February, 1997.
BIOTECHNOLOGY INVESTMENT GROUP, L.L.C.
By:COLLINSON HOWE VENTURE PARTNERS, INC.
Its: Managing Member
By: /s/Jeffrey J. Collinson
---------------------------------
Jeffrey J. Collinson, President
EDWARD BLECH TRUST
By: /s/Mordechai Jofen
---------------------------------
Mordechai Jofen, as Sole Trustee
COLLINSON HOWE VENTURE PARTNERS, INC.
By: /s/Jeffrey J. Collinson
---------------------------------
Jeffrey J. Collinson, President
/s/Jeffrey J. Collinson
---------------------------------
JEFFREY J. COLLINSON
SCHRODERS INCORPORATED
By: /s/Jeffrey J. Collinson
---------------------------------
Jeffrey J. Collinson
Its: Attorney-in-Fact
SCHRODER VENTURES U.S. TRUST
By: SCHRODER VENTURE MANAGERS LIMITED
Its: Manager
By: /s/Peter Everson
---------------------------------
Peter Everson
<PAGE> 15
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 15 OF 17
--------- ---- ----
- ------------------------- ------------------------------
SCHRODER VENTURES LIMITED
PARTNERSHIP
By: SCHRODER VENTURES MANAGEMENT L.P.
Its: General Partner
By: SCHRODER VENTURE MANAGERS INC.
Its: General Partner
By: /s/Peter Everson
------------------------------------
Peter Everson
<PAGE> 16
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 16 OF 17
--------- ---- ----
- ------------------------- ------------------------------
Exhibit 2
---------
POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below, and each entity for which an authorized signature appears below, hereby
constitutes and appoints Timothy C. Maguire and Anne G. Plimpton, and each of
them, each with full power to act without the other, his, her or its, as the
case may be, true and lawful attorney-in-fact, with full power of substitution,
to sign any and all instruments, certificates and documents that may be
necessary, desirable or appropriate to be executed on behalf of himself, herself
or itself, as the case may be, as an individual or in his, her or its, as the
case may be, capacity as a general partner of any partnership or a trustee of
any trust, pursuant to section 13 or 16 of the Securities Exchange Act of 1934,
as amended (the "Exchange Act"), and any and all regulations promulgated
thereunder, and to file the same, with all exhibits thereto, and any other
documents in connection therewith, all in connection with the beneficial
ownership of securities held by the undersigned, with the Securities and
Exchange Commission, and with any other entity when and if such is mandated by
the Exchange Act or by the By-laws of the National Association of Securities
Dealers, Inc., granting unto said attorney-in-fact full power and authority to
do and perform each and every act and thing necessary, desirable or appropriate,
fully to all intents and purposes as he might or could do in person, thereby
ratifying and confirming all that said attorney-in-fact, or his substitutes, may
lawfully do or cause to be done by virtue hereof. This Power of Attorney will
remain in effect until revoked by an instrument in writing delivered to the
aforesaid attorney(s)-in-fact. The undersigned each acknowledge that Timothy C.
Maguire and Anne G. Plimpton are not assuming any of the undersigned's
responsibilities to comply with Section 16 of the Securities Exchange Act of
1934.
IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 12th
day of February, 1997.
BIOTECHNOLOGY INVESTMENT GROUP, L.L.C.
By: COLLINSON HOWE VENTURE PARTNERS, INC.
Its: Managing Member
By: /s/Jeffrey J. Collinson
---------------------------------------
Jeffrey J. Collinson,
President
EDWARD BLECH TRUST
By: /s/Mordechai Jofen
---------------------------------------
Mordechai Jofen,
as Sole Trustee
/s/Mordechai Jofen
--------------------------------------------
Mordechai Jofen
COLLINSON HOWE VENTURE PARTNERS, INC.
By: /s/Jeffrey J. Collinson
---------------------------------------
Jeffrey J. Collinson,
President
<PAGE> 17
- ------------------------- ------------------------------
CUSIP NO. 015351109 13G PAGE 17 OF 17
--------- ---- ----
- ------------------------- ------------------------------
/s/Jeffrey J. Collinson
-----------------------------------------
Jeffrey J. Collinson
SCHRODERS INCORPORATED
By: /s/Jeffrey J. Collinson
-----------------------------------------
Jeffrey J. Collinson
Its: Attorney-in-Fact
SCHRODER VENTURES LIMITED PARTNERSHIP
By: SCHRODER VENTURES MANAGEMENT L.P.
Its: General Partner
By: SCHRODER VENTURE MANAGERS INC.
Its: General Partner
By: /s/Peter Everson
-----------------------------------------
Peter Everson
SCHRODER VENTURES U.S. TRUST
By: SCHRODER VENTURE MANAGERS LIMITED
Its: Manager
By: /s/Peter Everson
-----------------------------------------
Peter Everson
