ORAVAX INC /DE/
SC 13D/A, 1999-01-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                 SCHEDULE 13D

                 Under the Securities Exchange Act of 1934
                            (Amendment No. 2)(1)

                                  ORAVAX, INC.
           --------------------------------------------------------
                                (Name of Issuer)

                    COMMON STOCK, PAR VALUE $0.001 PER SHARE
           --------------------------------------------------------
                          (Title of Class of Securities)

                                  68554 R 10 7
           --------------------------------------------------------
                                 (CUSIP Number)

                                 DR. JOHN BROWN
                                 CHIEF EXECUTIVE
                         PEPTIDE THERAPEUTICS GROUP PLC
                     321 CAMBRIDGE SCIENCE PARK, MILTON ROAD
                           CAMBRIDGE CB4 4WG, ENGLAND
                               011-44-1223-423-333

                                 with a copy to:

                              MICHAEL LYTTON, ESQ.
                               PALMER & DODGE LLP
                                ONE BEACON STREET
                                BOSTON, MA 02110
                                 (617) 573-0100
           --------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                JANUARY 25, 1999
           --------------------------------------------------------
            (Date of Event which Requires Filing of this Statement)

     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box / /.

     NOTE: Schedules filed in paper format shall include a signed original
and five copies of the schedule, including all exhibits. SEE Rule 13d-7(b) for
other parties to whom copies are to be sent.

                         (Continued on following pages)

                               (Page 1 of 8 Pages)
- -----------------
         (1) The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.

         The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 (the "Act") or otherwise subject to the liabilities of that section
of the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


<PAGE>

CUSIP No. 68554 R 10 7                13D                 Page  2  of  8  pages



- -------------------------------------------------------------------------------
1.       NAME OF REPORTING PERSON
 
            -- Peptide Therapeutics Group PLC --

         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
- -------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)  /__/
                                                          (b)  /__/
                  Not Applicable
- -------------------------------------------------------------------------------
3.   SEC USE ONLY
- -------------------------------------------------------------------------------
4.   SOURCE OF FUNDS

                  WC
- -------------------------------------------------------------------------------
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO ITEM 2 (d) OR 2 (e)                    /__/

                  Not Applicable
- -------------------------------------------------------------------------------
6.   CITIZENSHIP OR PLACE OF ORGANIZATION

                  England and Wales
- -------------------------------------------------------------------------------
                                        7.   SOLE VOTING POWER

                                               2,193,537(1)
Number of                                  ------------------------------------
Shares                                  8. SHARED  VOTING POWER
Beneficially
Owned by                                             0(2)
Each 
Reporting                                  ------------------------------------
Person                                  9. SOLE DISPOSITION POWER

                                                2,193,517(1)
                                           ------------------------------------
                                       10. SHARED DISPOSITIVE POWER
                                           ------------------------------------

                                                   0(2)


- -------------------------------------------------------------------------------
11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
         PERSON
                           2,193,537(1)
- -------------------------------------------------------------------------------
12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
         /__/
                           Not Applicable
- -------------------------------------------------------------------------------
13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                  9.9%
- -------------------------------------------------------------------------------
14.      TYPE OF REPORTING PERSON
                  CO
- -------------------------------------------------------------------------------
(1) See Items 3 and 4.
(2) See Item 6.


<PAGE>

CUSIP No. 68554 R 107                 13D                     Page 3 of 8 Pages

- -------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSON

          Orange Acquisition Corp.

     I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
- -------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP  (a)  /__/
                                                       (b)  /__/

          Not Applicable
- -------------------------------------------------------------------------------
3.   SEC USE ONLY
- -------------------------------------------------------------------------------
4.   SOURCE OF FUNDS

          WC
- -------------------------------------------------------------------------------
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2
     (d) OR 2 (e) /__/

          Not Applicable
- -------------------------------------------------------------------------------
6.   CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware
- -------------------------------------------------------------------------------
                                        7.   SOLE VOTING POWER

                                               2,193,537(1)
Number of                                  ------------------------------------
Shares                                  8. SHARED  VOTING POWER
Beneficially
Owned by                                             0(2)
Each 
Reporting                                  ------------------------------------
Person                                  9. SOLE DISPOSITION POWER

                                                2,193,517(1)
                                           ------------------------------------
                                       10. SHARED DISPOSITIVE POWER
                                           ------------------------------------

                                                   0(2)


- -------------------------------------------------------------------------------
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                  2,193,537(1)
- -------------------------------------------------------------------------------
12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES /__/

          Not Applicable
- -------------------------------------------------------------------------------
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          9.9%
- -------------------------------------------------------------------------------
14.  TYPE OF REPORTING PERSON

          CO 
- -------------------------------------------------------------------------------
(1) See Items 3 and 4.
(2) See Item 6.


<PAGE>

CUSIP No.  68554 R 10 7               13D                      Page 4 of 8 Pages


     This Amendment No. 2 amends and supplements the Statement on Schedule 13D
(the "Original Statement") filed by Peptide Therapeutics Group PLC ("Peptide")
and Orange Acquisition Corp. ("Orange Sub" and together with Peptide the
"Purchaser") with the United States Securities and Exchange Commission on
November 20, 1998, as amended and supplemented pursuant to Amendment No. 1 filed
by Peptide and Orange Sub on January 11, 1999. Except as set forth below, there
are no changes to the information set forth in the Original Statement, as
amended. Capitalized terms used but not otherwise defined herein shall have the
meanings ascribed to them in the Original Statement.

ITEM 4.   PURPOSE OF TRANSACTION.

     Item 4 is amended by replacing the last two paragraphs thereof with the
following paragraphs:

     As described in Item 6 below, Peptide entered into the Standstill Agreement
(as defined below) with Pasteur Meriuex Serums et Vaccins S.A. ("PMC"), a
company organized under the laws of the Republic of France, pursuant to which
PMC has agreed not to engage in discussions with or acquire or offer to acquire
OraVax at any time prior to the effective time of the Merger or the termination
of the Standstill Agreement.

     OraVax and PMC are parties to joint venture and license agreements 
relating to the development of immuno-therapeutic and preventive vaccines. At 
the time of entering into the Standstill Agreement, a subsidiary of Peptide 
and PMC entered into an Overview Agreement dated January 25, 1999 (the 
"Overview Agreement") providing that, upon the effective time of the Merger, 
Peptide will cause OraVax to enter into certain modifications to its joint 
venture agreement with PMC, certain additional license agreements with PMC 
and an agreement to allow PMC at its option to defer an aggregate of $3 
million in future milestone payments to OraVax relating to certain license 
agreements between PMC and OraVax. In addition, PMC has agreed to make a $3 
million equity investment in ordinary shares of Peptide. The modification to 
the joint venture agreement would expand the joint venture to the development 
of vaccines against hepatitis C ("HEPC"). The additional license agreements 
relate to the development of vaccines against Japanese encephalitis ("JE"), 
tick borne encephalitis ("TBE") and HEPC based upon OraVax technology. Upon 
the effective time of the Merger, the additional license agreements would 
grant PMC world wide exclusive rights to the JE and TBE vaccines and a fifty 
percent share in world wide exclusive rights to the HEPC vaccines. OraVax 
will develop the vaccines through completion of early stage clinical trials. 
PMC will address advanced development, manufacturing, sales, marketing and 
distribution of the vaccines. The Overview Agreement may be terminated at any 
time prior to the effective time of the Merger (1) by mutual written consent 
of the parties; (2) upon termination of the Merger Agreement; or (3) by PMC 
upon (a) the public announcement of a tender or exchange offer for securities 
of OraVax by any person other than PMC, (b) any event that would entitle 
Peptide to terminate the Merger Agreement, (c) upon the public announcement 
of the submission to OraVax of an Acquisition Proposal (as defined in the 
Merger Agreement) by any person other than PMC, or (d) breach of certain 
representations and warranties contained in the Overview Agreement. A copy of 
the Overview Agreement is filed as Exhibit 5 hereto and incorporated herein 
by reference.

     On January 28, 1999, Peptide and OraVax entered into Amendment No. 1 to 
the Merger Agreement ("Amendment No. 1") to increase the total consideration 
of cash and Peptide stock payable to OraVax stockholders from $15 million to
$20 million. The $5 million increase will take the form of additional shares 
of Peptide stock issued to OraVax stockholders. The board of directors of 
OraVax has approved this increase in the stock consideration and confirmed 
its recommendation that the OraVax stockholders approve the Merger Agreement 
as amended. A copy of Amendment No. 1 is filed as Exhibit 6 hereto and 
incorporated herein by reference.

<PAGE>

CUSIP No.  68554 R 10 7               13D                      Page 5 of 8 Pages

     The foregoing summary of the contents of the Merger Agreement, Amendment 
No. 1, the Stock Purchase Agreement, the Standstill Agreement and the 
Overview Agreement is qualified in its entirety by reference to the exhibits 
hereto.

     Except as set forth in this Item 4, the Merger Agreement, Amendment No. 
1, the Stock Purchase Agreement, the Stockholder Voting Agreement (as 
described below), the Affiliate Letter (as described below), the Standstill 
Agreement (as described below) or the Overview Agreement, neither Peptide, 
Orange Sub or, to the best of Peptide's or Orange Sub's knowledge, any of the 
individuals named in Schedule I hereto, has any plans or proposals that 
relate to or that would result in any of the actions specified in clauses (a) 
through (j) of Item 4 of Schedule 13D.

ITEM 6.   CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS, OR RELATIONSHIPS WITH RESPECT
          TO SECURITIES OF THE ISSUER

     Item 6 is amended by replacing the last paragraph thereof with the
following paragraphs:

     Peptide has entered into a Standstill Agreement dated January 25, 1999 (the
"Standstill Agreement") with PMC in connection with a subsidiary of Peptide and
PMC entering into the Overview Agreement as described in Item 4 above. A copy of
the Standstill Agreement is filed as Exhibit 6 hereto and incorporated herein by
reference.

     The Standstill Agreement provides that, prior to the effective time of the
Merger or the termination of the Standstill Agreement, PMC will not directly or
indirectly (1) acquire or make any proposal to acquire any securities of OraVax
(except by way of stock dividends or other distributions or offerings made by
OraVax on a pro rata basis to OraVax stockholders) or seek or propose any
merger, consolidation, business combination, tender or exchange offer or sale or
purchase of all or a substantial portion of the assets of OraVax; (2) make or
participate in any solicitation of proxies to vote, or seek to advise or
influence any person with respect to the voting of, any voting securities of
OraVax; (3) form, join or in any way participate in a "group" (within the
meaning of Section 13(d)(3) of the Exchange Act of 1934, as amended) with
respect to any voting securities of OraVax or in connection with any of the
foregoing; (4) have any discussions or enter into any arrangements,
understandings or agreements with, or advise , assist or encourage, any other
persons in connection with any of the foregoing; or (5) announce an intention to
do any of the foregoing, provided that the foregoing shall not restrict PMC from
negotiating with OraVax with regard to a licensing transaction involving certain
OraVax technology or an Acquisition Proposal (as defined in the Merger
Agreement) if OraVax initiates such negotiations with PMC or if OraVax or
Peptide initiates such negotiations with any person other than PMC.

     The Standstill Agreement may be terminated at any time prior to the
effective time of the Merger (1) by mutual written consent of the parties; (2)
by PMC or Peptide upon the termination of the Merger Agreement; or (3) by PMC
upon (a) the public announcement of a tender or exchange offer for securities of
OraVax, (b) the occurrence of certain events that would entitle Peptide to
terminate the Merger Agreement ("Termination Events"), (c) the public
announcement of the submission to OraVax of a bona fide Acquisition Proposal by
any person other than PMC, or (d) any modification or amendment of the Merger
Agreement which PMC reasonably determines to be 


<PAGE>

CUSIP No.  68554 R 10 7               13D                      Page 6 of 8 pages


adverse to OraVax stockholders or which extends the July 31, 1999 termination
date of the Merger Agreement. Pursuant to the Standstill Agreement, Peptide
shall promptly inform PMC if it becomes aware of the occurrence of any
Termination Events or the submission of an Acquisition Proposal to OraVax. The
Standstill Agreement shall terminate on October 31, 1999 to the extent it is not
otherwise terminated prior to that date.

     The foregoing summary of the contents of the Stockholder Voting Agreement,
the Affiliate Letter and the Standstill Agreement is qualified in its entirety
by reference to the exhibits hereto.

     Except as provided in the Merger Agreement, Amendment No. 1, the Stock 
Purchase Agreement, the Stockholder Voting Agreement, the Affiliate Letter, 
the Standstill Agreement or the Overview Agreement, or as set forth herein, 
neither Peptide, Orange Sub or, to the best of Peptide's or Orange Sub's 
knowledge, any of the individuals named in Schedule I hereto, has any 
contracts, arrangements, understandings or relationships (legal or otherwise) 
with any person with respect to any securities of OraVax, including, but not 
limited to, transfer or voting of any securities, finder's fees, joint 
ventures, loan or option arrangements, puts or calls, guarantees of profits, 
division of profits or losses, or the giving or withholding of proxies.

ITEM 7.   MATERIAL TO BE FILED AS EXHIBITS

     Item 7 is amended by adding the following to the list of exhibits:

     Exhibit 5 - Overview Agreement dated January 25, 1999 by and between
                 Peptide Therapeutics Limited and Pasteur Meriuex Serums et
                 Vaccins S.A. (Incorporated by reference to Form F-4 to be
                 filed by Peptide Therapeutics Group plc with the Securities
                 and Exchange Commission.)

     Exhibit 6 - Amendment No. 1 to Restated Agreement and Plan of Acquisition
                 dated January 28, 1999 by and among Peptide Therapeutics
                 Group plc, Peach Acquisition Corp. and OraVax, Inc.

     Exhibit 7 - Standstill Agreement dated January 25, 1999 by and between
                 Peptide Therapeutics Group plc and Pasteur Meriuex Serums et
                 Vaccins S.A.


<PAGE>

CUSIP No.  68554 R 10 7               13D                      Page 7 of 8 pages



                                    SIGNATURE

     After reasonable inquiry and to the best of their knowledge and belief,
each of the undersigned corporations certifies that the information set forth in
this statement is true, complete and correct.



                                        January 28, 1999


                                        PEPTIDE THERAPEUTICS GROUP PLC


                                        By: /s/ Gordon Cameron
                                            -----------------------
                                            Gordon Cameron
                                            Finance Director


                                        ORANGE ACQUISITION CORP.


                                        By: /s/ Gordon Cameron
                                            -----------------------
                                            Gordon Cameron
                                            Treasurer


<PAGE>

CUSIP No.  68554 R 10 7               13D                      Page 8 of 8 pages



                                  EXHIBIT INDEX

<TABLE>
<CAPTION>

Exhibit                  Description
- -------                  -----------
<S>                 <C>
  1                 Form of Stock Purchase Agreement by and among Orange
                    Acquisition Corp. and certain stockholders of OraVax, Inc.*

  2                 Agreement and Plan of Acquisition dated as of November 10,
                    1998 by and among Peptide Therapeutics Group plc, Peach
                    Acquisition Corp. and OraVax, Inc. (Incorporated by
                    reference to Exhibit 2.1 to the Form 8-K filed on November
                    19, 1998 by OraVax, Inc., File No. 0-26034.)

  3                 Form of Stockholder Voting Agreement by and among Peptide
                    Therapeutics Group plc and certain stockholders of OraVax,
                    Inc.*

  4                 Agreement as to Joint Filing of Schedule 13D.*

  5                 Overview Agreement dated January 25, 1999 by and between
                    Peptide Therapeutics Limited and Pasteur Meriuex Serums et
                    Vaccins S.A. (Incorporated by reference to Form F-4 to be
                    filed by Peptide Therapeutics Group plc with the Securities
                    and Exchange Commission.)

  6                 Amendment No. 1 to Restated Agreement and Plan of 
                    Acquisition dated January 28, 1999 by and among Peptide
                    Therapeutics Group plc, Peach Acquisition Corp. and 
                    OraVax, Inc.

  7                 Standstill Agreement dated January 25, 1999 by and between
                    Peptide Therapeutics Group plc and Pasteur Meriuex Serums et
                    Vaccins S.A.

</TABLE>


- --------------------
*    Previously filed.


<PAGE>


                                                                     EXHIBIT6

                           AMENDMENT NO 1. TO RESTATED
                       AGREEMENT AND PLAN OF ACQUISITION


     This Amendment No. 1 to Restated Agreement and Plan of Acquisition (this 
"Amendment") is entered into as of January 28, 1999 by and among Peptide 
Therapeutics Group plc ("Parent"), Peach Acquisition Corp. ("Merger Sub") and 
OraVax, Inc. ("Seller"). Capitalized terms not otherwise defined herein shall 
have the meanings given to them in that certain Agreement and Plan of 
Acquisition dated as of November 10, 1998 among Parent, Merger Sub and Seller 
(as restated, the "Merger Agreement").

     WHEREAS, Parent, Merger Sub and Seller have entered into the Merger 
Agreement pursuant to which Seller shall be acquired by Parent through a 
merger of Merger Sub with and into Seller; and

     WHEREAS, Parent, Merger Sub and Seller desire to amend the Merger 
Agreement as set forth herein pursuant to Section 9.5 thereto;

     NOW, THEREFORE, the parties, intending to be legally bound, hereby agree 
as follows:

     1.  Section 1.6(a)(i) of the Merger Agreement is hereby amended by 
replacing "$15,000,000" with "$20,000,000" in the second sentence of that 
section.

     2.  Except as amended hereby, the Merger Agreement shall remain 
unchanged and shall remain in full force and effect.

     3.  This Amendment may be executed in any number of counterparts, each 
of which shall be an original, but all of which together shall constitute one 
instrument.

<PAGE>

     IN WITNESS WHEREOF, the parties have caused this Amendment to be 
executed by their respective duly authorized representatives as of the date 
first above written.

                                        PEPTIDE THERAPEUTICS GROUP PLC

                                        By: /s/ Gordon Cameron
                                            ---------------------------
                                                Gordon Cameron
                                                Finance Director



                                        PEACH ACQUISITION CORP.

                                        By: /s/ Gordon Cameron
                                            ---------------------------
                                                Gordon Cameron
                                                Treasurer



                                        ORAVAX, INC.

                                        By: /s/ Lance Gordon
                                            ---------------------------
                                                Lance Gordon
                                                President and CEO



<PAGE>

                                                                       EXHIBIT 7


                              STANDSTILL AGREEMENT

     THIS STANDSTILL AGREEMENT (this "Agreement") is entered into as of January
25, 1999 by and between Peptide Therapeutics Group plc, a corporation organized
under the laws of England and Wales ("Peptide"), and Pasteur Merieux Serums &
Vaccins S.A., a societe anonyme existing and organized under the laws of the
Republic of France ("PMC").

     WHEREAS, Peptide, Peach Acquisition Corp. and OraVax, Inc. ("OraVax") have
entered into an Agreement and Plan of Acquisition, dated November 10, 1998 (the
"Merger Agreement"), whereby OraVax is to be acquired by Peptide by way of a
merger (the "Merger") of OraVax with and into Peach Acquisition Corp.;

     WHEREAS, simultaneously with the execution of this Agreement, Peptide and
PMC have entered into an agreement (the "Overview Agreement") whereby Peptide
has agreed, to, among other things, cause OraVax, upon the effective time of the
Merger (the "Effective Time"), to enter into certain agreements providing for
the licensing to PMC of specific OraVax technology;

     WHEREAS, in connection with the execution of the Overview Agreement, the
parties hereto wish to provide herein, among other things, for certain
agreements regarding PMC's ability to take certain actions with respect to
OraVax pending the Effective Time;

     NOW, THEREFORE, in consideration of the mutual agreements herein set forth
and for other good and valuable consideration the receipt of which is hereby
acknowledged, the parties hereby agree as follows:

                                    ARTICLE I
                                 PMC STANDSTILL

     1.1  PMC agrees that, prior to the earlier of the Effective Time and the
date of the termination of this Agreement pursuant to Article II below, PMC
shall not, and shall cause each of its affiliates (as defined in Rule 12b-2
promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange
Act")) not to, directly or indirectly:

          (a) acquire or make any proposal to acquire any securities of OraVax
     (except by way of stock dividends or other distributions or offerings made
     by OraVax on a pro rata basis to its security holders) or seek or propose
     any merger, consolidation, business combination, tender or exchange offer
     or sale or purchase of all or a substantial portion of the assets of
     OraVax, it being understood that nothing in this Section 1.1 shall restrict
     the ability of PMC and its affiliates as it relates to enforcement of PMC's
     rights arising under that certain loan and security arrangement dated
     November 2, 1998 between PMC and OraVax JVM, Inc.;


                                       1

<PAGE>

          (b) make, or in any way participate in, any "solicitation" of
     "proxies" (as such terms are used in the proxy rules of the Securities and
     Exchange Commission) to vote, or seek to advise or influence any person
     with respect to the voting of, any voting securities of OraVax;

          (c) form, join or in any way participate in a "group" (within the
     meaning of Section 13(d)(3) of the Exchange Act) with respect to any voting
     securities of OraVax or in connection with any of the foregoing;

          (d) have any discussions or enter into any arrangements,
     understandings or agreements with, or advise, assist or encourage, any
     other persons in connection with any of the foregoing; or

          (e) announce an intention to do any of the foregoing.

     1.2  The parties agree that the foregoing shall not restrict PMC from
entering into negotiations with OraVax regarding (i) a licensing transaction
with respect to any of the Proprietary Rights which are the subject of any of
Annexes A - C to the Overview Agreement, or (ii) an Acquisition Proposal, if in
either case, OraVax initiates negotiations with PMC or PMC knows or becomes
aware that OraVax or Peptide (or any of their respective officers, members of
the board of directors, or any person acting at the direction of, or to the
knowledge of any of the foregoing) initiates negotiations with a third party
with respect to any of the foregoing.


                                   ARTICLE II
                                  TERMINATION

     2.1  This Agreement may be terminated at any time prior to the Effective
Time:

          (a) By mutual written consent of the parties hereto;

          (b) By PMC or Peptide, by written notice to the other, upon the
     termination of the Merger Agreement (provided that, with respect to PMC's
     termination right hereunder, the termination of the Merger Agreement does
     not result from the breach by PMC of Article I of this Agreement); or

          (c) By PMC, by written notice to Peptide (provided that with respect
     to PMC's termination right hereunder the occurrence of the events under
     clauses (i), (ii), (iii), or (iv) hereunder, as applicable in the
     particular instance, giving rise to the termination right, does not result
     from the breach by PMC of Article I of this Agreement):

          (i)  upon the public announcement of the commencement of, or an
               intention to commence or make, a tender offer or exchange offer


                                       2

<PAGE>

               by any person other than PMC or an affiliate of PMC for
               securities of OraVax;

          (ii) upon the occurrence of any event that would entitle Peptide to
               terminate the Merger Agreement under any of Section 9.1(c)(ii)
               [board recommendation or improper response to Acquisition
               Proposal], Section 9.1(d)(i) - (iv) [outside date, injunction,
               shareholder rejection], or Section 9.1(c)(i) [breach] if the
               circumstances permitting such termination relate to a breach of
               Section 5.1(a)(iv) [preservation of intellectual property rights]
               or Section 5.2(b)(ii) [disposition of material assets], if in
               either case the assets at issue are Proprietary Rights which are
               the subject of Annexes A - C to the Overview Agreement or Section
               5.10 [no solicitation], (provided that such right to terminate
               the Merger Agreement does not result from the breach by PMC of
               Article I of this Agreement), irrespective of any waivers or
               extensions of time to perform that may be given by Peptide to
               OraVax under the Merger Agreement and irrespective of any breach
               by Peptide of any representations, warranties, covenants or other
               agreements contained in the Merger Agreement;

         (iii) upon the public announcement of, or PMC otherwise becoming
               aware of, the submission to OraVax by any person other than
               PMC or an affiliate of PMC of a bona fide Acquisition
               Proposal (as defined in the Merger Agreement), which in the
               reasonable judgment of PMC is capable of being financed and
               consummated by the person making the Acquisition Proposal;
               or

          (iv) upon the modification, amendment or waiver of any term or
               condition of the Merger Agreement (x) which is reasonably
               determined by PMC to be adverse to the stockholders of
               OraVax (it being understood that a reduction in the amount
               per share or nature or method of payment of consideration to
               the common stockholders of OraVax shall be deemed to be
               adverse) or (y) which extends the July 31, 1999 outside
               termination date under the Merger Agreement.

     2.2  Peptide shall promptly notify PMC if it becomes aware that there has
occurred any event referenced in Sections 2.1(c)(ii) above or of the submission
of an Acquisition Proposal referenced in Section 2.1(c)(iii) above.

     2.3  No termination of this Agreement shall relieve any party from 
liability by reason of any breach by such party of any of its covenants or
representations contained herein occurring prior to the termination of this
Agreement.


                                       3

<PAGE>

                                   ARTICLE III
                                 REPRESENTATIONS

     3.1  Each of the parties hereto represents and warrants with respect to
itself that such party is duly authorized to execute, deliver and perform this
Agreement, that this Agreement has been duly executed and delivered by such
party and that this Agreement is a valid and binding agreement of such party,
enforceable against such party in accordance with its terms.

                                   ARTICLE IV
                                  MISCELLANEOUS

     4.1  All notices and other communications required or permitted hereunder
shall be in writing and shall be deemed given when so delivered in person, one
business day after delivery to an overnight courier, upon facsimile transmission
(with receipt confirmed by telephone or by automatic transmission report) or two
business days after being sent by registered or certified mail (postage prepaid,
return receipt requested), as follows:

               (a)  If to Peptide, to:

                    Peptide Therapeutics Group plc
                    321 Cambridge Science Park
                    Milton Road
                    Cambridge CB4 4WG
                    England
                    Attn:    Chief Executive
                    Telephone:       01223 423333
                    Facsimile:       01223 423341

                    with a copy to:

                    Palmer & Dodge LLP
                    One Beacon Street
                    Boston, Massachusetts  02108
                    Attn:    Michael Lytton, Esq.
                    Telephone:       (617) 573-0100
                    Facsimile:       (617) 227-4420

               (b)  If to PMC, to:

                    Pasteur Merieux Serums & Vaccins S.A.
                    58, avenue Leclerc
                    69007 Lyon, France
                    Attn:    Senior Vice President, Corporate and Legal Affairs,
                             and General Counsel
                    Telephone:       011 33 4 37 37 77 84
                    Facsimile:       011 33 4 37 37 70 61


                                       4

<PAGE>

                    with a copy to:

                    Akin, Gump, Strauss, Hauer & Feld, L.L.P.
                    590 Madison Avenue
                    New York, New York  10022
                    Attn:    L. Kevin O'Mara, Jr.
                    Telephone:       (212) 872-1000
                    Facsimile:       (212) 872-1002


Any party may by notice given in accordance with this Section 4.1 to the other
party designate another address or person for receipt of notices hereunder.

     4.2  This Agreement shall be construed in accordance with and governed by
the internal laws of the State of Delaware. Each party hereby irrevocably
submits to the non-exclusive jurisdiction of any state or federal court in the
State of Delaware or the State of New York with respect to any suit, action,
proceeding or judgment relating to or arising out of this Agreement. PMC agrees
that money damages would not be sufficient remedy for Peptide for any breach of
this Agreement by PMC, and that in addition to all other remedies Peptide may
have, Peptide shall be entitled to specific performance and to injunctive or
other equitable relief as a remedy for any such breach. PMC agrees not to oppose
the granting of such relief in the event a court determines that such breach has
occurred, and agrees to waive any requirement for the securing or posting of any
bond in connection with such remedy.

     4.3  This Agreement may be amended, modified or supplemented only by 
written agreement of the parties hereto.

     4.4  This Agreement and all of the provisions hereof shall be binding upon
and inure to the benefit of the parties hereto and their respective successors
and permitted assigns. This Agreement is not assignable without the prior
written consent of the other party hereto.

     4.5  This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

     4.6  This Agreement contains the entire agreement between the parties in
respect of the subject matter contained herein, and supersedes all prior
agreements, written or oral, with respect thereto.

     4.7  If one or more provisions of this Agreement are held to be
unenforceable under applicable law, such provision shall be excluded from this
Agreement and the balance of the Agreement shall be interpreted as if such
provision were so excluded and shall be enforceable in accordance with its
terms.


                                       5

<PAGE>

     4.8  Notwithstanding anything to the contrary contained herein, the
Agreement and the obligation of the parties hereunder shall terminate on October
31, 1999 to the extent this Agreement has not been otherwise terminated prior to
that date.


                                       6

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed as of the day and year first written above.


                                        PEPTIDE THERAPEUTICS GROUP PLC


                                        By: /s/ Nicolas Higgins 
                                            ---------------------
                                            Name:  Nicolas Higgins
                                            Title: Commercial Director



                                        PASTEUR MERIEUX SERUMS & VACCINS S.A.


                                        By: /s/ Paul Kirkconnell
                                            ----------------------
                                            Name:  Paul Kirkconnell
                                            Title: Corporate Vice President



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