INNOVIR LABORATORIES INC
8-K, 1997-01-07
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                   ----------

                                    FORM 8-K

                                   ----------


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


       Date of Report (Date of earliest event reported) December 23, 1996



                           INNOVIR LABORATORIES, INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)



          DELAWARE                       0-21972                 13-3536290
- ----------------------------           ------------          -------------------
(State or other jurisdiction           (Commission              (IRS Employer
      of incorporation)                File Number)          Identification No.)



           510 EAST 73RD STREET, NEW YORK, NY                  10021
        ----------------------------------------             ----------
        (Address of principal executive offices)             (Zip Code)



       Registrant's telephone number, including area code: (212) 249-4703



                                 Not Applicable
          -------------------------------------------------------------
          (Former name or former address, if changed since last report)

================================================================================



<PAGE>


ITEMS 1 & 2. CHANGES IN CONTROL OF REGISTRANT AND 
             ACQUISITION OR DISPOSITION OF ASSETS.

     On December 23, 1996, VIMRx Pharmaceuticals Inc. ("VIMRx") acquired
beneficial ownership of approximately 68% of the issued and outstanding voting
securities of Innovir Laboratories, Inc. (the "Registrant"), pursuant to (i) an
agreement, dated November 21, 1996, as amended (the "Aries Agreement"), among
VIMRx and The Aries Fund, A Cayman Island Trust ("The Aries Trust"), and The
Aries Domestic Fund, L.P., a Delaware limited partnership ("The Aries Limited
Partnership" and, together with The Aries Trust, "The Aries Funds"), and (ii) an
agreement, dated November 21, 1996 (the "VIMRx Agreement" and, together with the
Aries Agreement, the "Agreements"), between the Registrant and VIMRx. In
addition, upon exercise of certain warrants issued by the Registrant to VIMRx
and as a result of an irrevocable voting proxy granted to VIMRx by The Aries
Funds with respect to securities of Innovir owned by The Aries Funds (see
below), VIMRx may be deemed to have voting control of up to an aggregate of
approximately 74% of the Registrant's voting securities.

     Pursuant to the Aries Agreement, The Aries Funds, which owned 4,000,000
shares of the Registrant's common stock, $.013 par value ("Common Stock"), prior
to the consummation of the transactions contemplated thereby, (i) exercised
warrants and unit purchase options to acquire an additional 6,000,000 shares of
Common Stock and additional warrants to purchase 2,000,000 shares of Common
Stock, which exercises resulted in payment by The Aries Funds to the Registrant
of an aggregate exercise price of $3,000,000, and (ii) transferred to VIMRx
9,500,000 shares of Common Stock in exchange for $3,000,000 in cash and
3,000,000 newly issued shares of VIMRx's common stock, $.001 par value.

     Pursuant to the VIMRx Agreement, the Registrant acquired from VIMRx all of
the capital stock of VIMRx's wholly-owned subsidiary, VIMRx Holdings, Ltd., a
Delaware corporation ("VHL"), to which VIMRx had made a capital contribution of
$4,000,000 prior to the closing, in exchange for 8,666,666 shares of the
Registrant's Class D Convertible Preferred Stock (the "D Preferred Stock")
(which D Preferred Stock is convertible into 8,666,666 shares of Common Stock)
and five-year warrants to purchase an additional 2,000,000 shares of Common
Stock (1,000,000 shares of which may be purchased at an exercise price of $1.00
per share and 1,000,000 shares of which may be purchased at an exercise price of
$2.00 per share). Pursuant to a Services Agreement between the Registrant and
VIMRx, VIMRx has agreed that, when, as and if requested by the Registrant, VIMRx
shall provide to the Registrant certain services, including, without limitation,
management, finance, administration and business development services, the
payment for which services will be determined in accordance with VIMRx's normal
accounting procedures. In addition, the Registrant has agreed to convene a
meeting of its stockholders to, inter alia, approve an amendment to the
Registrant's certificate of incorporation to increase the authorized number of
shares of Common Stock to 70,000,000 shares. In the event that the Registrant
does not have a sufficient number of shares of Common Stock authorized for
issuance upon conversion of the D Preferred Stock by June 30, 1997, each share
of the D Preferred Stock will be convertible into one and one-half shares of
Common Stock.

     Lindsay A. Rosenwald, M.D., a director of VIMRx, serves as the President
and is the sole shareholder of each of the investment manager of The Aries Trust
and the general partner of The Aries Limited Partnership. Michael S. Weiss and
Joseph E. Edelman, The Aries Funds' designees, were members of the Registrant's
Board of Directors prior to the consummation of the transactions contemplated by
the Agreements. The acquisition of VHL by the Registrant was negotiated on an
arm's length basis, and the Registrant received an opinion issued by an
independent investment banking firm that the consideration


                                       -2-



<PAGE>


received in the transaction contemplated by the VIMRx Agreement was fair from a
financial point of view to the Registrant's stockholders.

     Pursuant to the Agreements: (i) VIMRx has agreed to exercise its warrant to
purchase 1,000,000 shares of Common Stock at $1.00 per share (for an aggregate
exercise price of $1,000,000) upon receipt of a written request from the
Registrant's Board of Directors subsequent to May 31, 1997 specifying that the
Registrant has insufficient funds to continue its operations; (ii) The Aries
Funds have agreed to exercise warrants to purchase 2,000,000 shares of Common
Stock at $.50 per share (for an aggregate exercise price of $1,000,000) in the
event that VIMRx exercises its warrant in accordance with clause (i) above and
have granted VIMRx an irrevocable voting proxy through November 31, 1999 with
respect to the shares of Common Stock so acquired (which proxy will not restrict
The Aries Funds from selling such shares and will lapse with respect to any such
shares sold); and (iii) The Aries Funds have granted VIMRx an irrevocable voting
proxy with respect to the 500,000 shares of Common Stock currently owned by The
Aries Funds (which proxy will not restrict The Aries Funds from selling such
shares and will lapse with respect to any such shares sold).

     In connection with, and prior to the consummation of, the transactions
contemplated by the Agreements, The Aries Funds' designees to the Registrant's
Board of Directors, Messrs. Weiss and Edelman, resigned as members of the
Registrant's Board of Directors. In addition, upon consummation of the
transactions, four new directors, designated by VIMRx, were elected to the
Registrant's Board of Directors: Richard L. Dunning, President and Chief
Executive Officer of VIMRx; Francis M. O'Connell, Chief Financial Officer of
VIMRx; David A. Jackson, Executive Vice President and Chief Scientific Officer
of VIMRx; and Laurence D. Fink, a director of VIMRx. Prior to the consummation
of the transactions contemplated by the Agreements, Maurice R. Hilleman, Ph.D.
also resigned from the Registrant's Board of Directors and agreed to join the
Registrant's Science Advisory Board.

     The Registrant and VHL are both engaged in developing therapeutic
technologies that seek to control disease-triggering flaws in individuals'
genetic chemistry. The Registrant's and VHL's technologies are based on
different classes of catalytically active oligomers (referred to by the
Registrant as "Oligozymes") that have demonstrated the ability to inactivate
certain RNA "messenger" molecules which direct cells to produce disease-causing
proteins. To date, the Registrant has focused on the development of External
Guide Sequence Oligozymes for new therapeutic applications. VHL, through its
three wholly-owned subsidiaries, has focused on the development of RILON(R)
Oligozymes.


                                       -3-



<PAGE>


ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

  (A) FINANCIAL STATEMENTS OF BUSINESSES ACQUIRED.

     It is impracticable to provide the required financial statements for the
acquired business at the date of filing of this Form 8-K. Such financial
statements will be filed as soon as practicable but not later than 60 days after
the date that this initial report on Form 8-K must be filed.

  (B) PRO FORMA FINANCIAL INFORMATION.

     It is impracticable to provide the required pro forma financial statements
for the acquired business at the date of filing of this Form 8-K. Such financial
statements will be filed as soon as practicable but not later than 60 days after
the date that this initial report on Form 8-K must be filed.

  (C) EXHIBITS.

      4.1   Certificate of Designation, Number, Powers, Preferences and
            Relative, Participating, Optional and Other Special Rights and the
            Qualifications, Limitations, Restrictions and Other Distinguishing
            Characteristics of Class D Convertible Preferred Stock of the
            Registrant, as filed on December 12, 1996.*

      10.1  Agreement, dated as of November 21, 1996, among VIMRx
            Pharmaceuticals Inc. and the Registrant.

      10.2  Agreement and Waiver, dated December 23, 1996, by and among VIMRx,
            the Registrant and The Aries Funds.

      10.3  Services Agreement, dated December 23, 1996, by and between VIMRx
            and the Registrant.

      20.1  Press release, dated January 2, 1997.

- ----------

* Incorporated by reference to the Registrant's Annual Report on Form 10-K 
  for the year ended September 30, 1996.


                All other Items of this report are inapplicable.


                                       -4-



<PAGE>



                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.



                                          INNOVIR LABORATORIES, INC.


Date:  January 7, 1997                    By:  /s/ GARY POKRASSA
                                               -----------------
                                          Name:  Gary Pokrassa
                                          Title:  Vice President -- Finance


                                       -5-



<PAGE>


                                  EXHIBIT INDEX

      4.1   Certificate of Designation, Number, Powers, Preferences and
            Relative, Participating, Optional and Other Special Rights and the
            Qualifications, Limitations, Restrictions and Other Distinguishing
            Characteristics of Class D Convertible Preferred Stock of the
            Registrant, as filed on December 12, 1996.*

      10.1  Agreement, dated as of November 21, 1996, among VIMRx
            Pharmaceuticals Inc. and the Registrant.

      10.2  Agreement and Waiver, dated December 23, 1996, by and among VIMRx,
            the Registrant and The Aries Funds.

      10.3  Services Agreement, dated December 23, 1996, by and between VIMRx
            and the Registrant.

      20.1  Press release, dated January 2, 1997.

- ----------

* Incorporated by reference to the Registrant's Annual Report on Form 10-K 
  for the year ended September 30, 1996.


                                       -6-




                                    AGREEMENT

                                  by and among

                           VIMRx PHARMACEUTICALS INC.

                                       and

                           INNOVIR LABORATORIES, INC.

                            Dated: November 21, 1996


<PAGE>


                                TABLE OF CONTENTS

                                                                        Page
                                                                        ----

AGREEMENT.............................................................    1
                                                                          
ARTICLE 1    EXCHANGE.................................................    1
    1.1      Exchange.................................................    1
                                                                          
ARTICLE 2    REPRESENTATIONS AND WARRANTIES OF VIMRx..................    2
    2.1      Organization and Authority...............................    2
    2.2      Capitalization...........................................    2
    2.3      Subsidiaries.............................................    2
    2.4      Articles of Incorporation, By-Laws and                       
               Corporate Records......................................    2
    2.5      Governmental Authorizations and Other Consents...........    3
    2.6      Non-Contravention........................................    3
    2.7      Financial Statements.....................................    3
    2.8      Tangible Property........................................    4
    2.9      Real Property and Leases.................................    4
    2.10     Intellectual Property....................................    4
    2.11     Tax Matters..............................................    4
    2.12     Compliance with Laws.....................................    5
    2.13     Permits and Licenses.....................................    5
    2.14     Contracts and Agreements.................................    5
    2.15     Employee Benefits........................................    5
    2.16     Accounts Payable.........................................    6
    2.17     Liabilities..............................................    6
    2.18     Actions and Proceedings..................................    6
    2.19     Bank Accounts, Guarantees and Powers.....................    6
    2.20     Absence of Changes.......................................    6
    2.21     Employee Relations.......................................    7
    2.22     Affiliated Transactions..................................    7
    2.23     Brokers' Fees............................................    8
    2.24     Full Disclosure..........................................    8
    2.25     Employee Compensation....................................    8
    2.26     Authority................................................    8
    2.27     Title to the VHL Shares..................................    8
    2.28     Examination of Documents, Investment Purposes and            
               Legending of Innovir Shares and Innovir Warrants.......    8
    2.29     Insurance................................................    9
    2.30     Environmental............................................    9
                                                                          
                                                                          
                                        i                                 
                                                                          
                                                                          
<PAGE>                                                                  
                                                                        Page
                                                                        ----

ARTICLE 3    REPRESENTATIONS AND WARRANTIES OF INNOVIR................   9
    3.1      Organization.............................................   9
    3.2      Authority and Consent....................................  10
    3.3      Non-Contravention........................................  10
    3.4      Capitalization...........................................  10
    3.5      Intellectual Property....................................  10
    3.6      Actions and Proceedings..................................  11
    3.7      Absence of Changes.......................................  11
    3.8      The Innovir Shares.......................................  11
    3.9      The Innovir Warrants.....................................  12
    3.11     Documents Delivered......................................  12
                                                                        
ARTICLE 4    CONDUCT PENDING CLOSING BY VHL AND                         
               THE SUBSIDIARIES ......................................  12
    4.1      Conduct of Business......................................  12
    4.2      Certain Prohibited Activities............................  13
    4.3      Reports; Taxes; Etc......................................  13
    4.4      Access to Information....................................  13
    4.5      Further Assurances.......................................  14
    4.6      Tax Adjustments..........................................  14
    4.7      Governmental Notification and Approvals..................  14
                                                                        
ARTICLE 5    CONDUCT PENDING CLOSING BY INNOVIR ......................  14
    5.1      Conduct of Business......................................  14
    5.2      Certain Prohibited Activities............................  14
    5.3      Reports; Taxes; Etc......................................  15
    5.4      Access to Information....................................  15
    5.5      Further Assurances.......................................  15
    5.6      Tax Adjustments..........................................  16
    5.7      Governmental Notification and Approvals..................  16

ARTICLE 6    COVENANTS OF VIMRx AND INNOVIR...........................  16
    6.1      Necessary Assurances.....................................  16
    6.2      Filings and Consents.....................................  16
    6.3      Government Filings.......................................  16
    6.4      Public Announcements.....................................  17
    6.5      Confidentiality..........................................  17
    6.6      Expenses.................................................  17
                                                                        
                                                                      
                                                                      
                                       ii


<PAGE>

                                                                       Page
                                                                       -----

ARTICLE 7    ADDITIONAL COVENANTS.....................................  17
    7.1      VIMRx Covenants..........................................  17
    7.2      Innovir Covenant.........................................  17

ARTICLE 8    CONDITIONS TO CLOSING....................................  18
    8.1      Conditions to Obligations of Innovir.....................  18
    8.2      Conditions to Obligations of VIMRx.......................  19

ARTICLE 9    CLOSING..................................................  19
    9.1      Closing Date.............................................  19
    9.2      Deliveries by VIMRx......................................  20
    9.3      Deliveries by Innovir....................................  20

ARTICLE 10   SURVIVAL.................................................  21
    10.1     Survival.................................................  21

ARTICLE 11   INDEMNIFICATION..........................................  21
    11.1     Indemnification..........................................  21
    11.2     Access...................................................  22

ARTICLE 12   MISCELLANEOUS PROVISIONS.................................  22
    12.1     Amendment and Modification...............................  22
    12.2     Waiver of Compliance.....................................  22
    12.3     Notices..................................................  22
    12.4     Assignment...............................................  23
    12.5     Third Parties............................................  24
    12.6     Governing Law............................................  24
    12.7     Counterparts.............................................  24
    12.8     Headings.................................................  24
    12.9     Entire Agreement.........................................  24


                                       iii


<PAGE>


                                    AGREEMENT

     AGREEMENT (the "Agreement") made this 21st day of November, 1996 by and
among VIMRx Pharmaceuticals Inc., a Delaware corporation with offices at 2751
Centerville Road, Wilmington, Delaware 19808 ("VIMRx"), and Innovir
Laboratories, Inc., a Delaware corporation with offices at 510 East 73rd Street,
New York, New York 10021 ("Innovir").

                                 R E C I T A L S

     WHEREAS, Innovir is desirous of acquiring all of the issued and outstanding
shares of the capital stock of VIMRx Holdings, Ltd., a Delaware corporation
("VHL") consisting of 12,000 shares of common stock, $.01 par value (the "VHL
Shares"), solely in exchange for 8,666,6661(1) shares of Innovir's Class D
Convertible Preferred Stock, par value $.06 per share (the "Innovir Shares") and
five-year warrants to purchase 1,000,000 shares of Innovir's Common Stock at
$1.00 per share and 1,000,000 shares at $2.00 per share (the "Innovir
Warrants"); and

     WHEREAS, VIMRx is the owner of the VHL Shares and is desirous of exchanging
the VHL Shares for the Innovir Shares and has agreed to cause VHL to advance
$1,000,000 to Innovir concurrent with the signing of this Agreement;

     NOW, THEREFORE, Innovir and VIMRx hereby agree as follows:

                                    ARTICLE 1

                                    EXCHANGE

     1.1 Exchange. Subject to the terms and conditions of this Agreement and in
reliance upon the representations, warranties and covenants herein contained, on
the date of closing specified in Section 9.1 (the "Closing Date"), VIMRx hereby
agrees to assign, transfer and deliver the VHL Shares to Innovir or its designee
and, in exchange therefor, Innovir hereby agrees to issue and deliver the
Innovir Shares and the Innovir Warrants to VIMRx.

- --------

(1)  The number of Innovir Shares were calculated valuing VHL at $13,000,000
     following an additional $3,000,000 cash infusion to be made prior to
     closing, divided by $1.50, the per share value attributed to the Innovir
     Shares.


<PAGE>



                                    ARTICLE 2

                     REPRESENTATIONS AND WARRANTIES OF VIMRx

     VIMRx represents and warrants to Innovir that:

     2.1 Organization and Authority. VHL is a corporation duly organized,
validly existing and in good standing under the laws of the State of Delaware,
has all requisite corporate power and authority to own, lease and operate its
properties and carry on its business as now conducted, and is not required to be
qualified as a foreign corporation in any other jurisdiction.

     2.2 Capitalization. The authorized capital stock of VHL consists of 120,000
shares of common stock, $.01 par value. The VHL Shares have been duly authorized
and are validly issued, fully paid and nonassessable, constitute the only shares
of VHL outstanding and there are no outstanding rights, subscriptions, warrants,
calls, preemptive rights, options or other agreements or commitments of any kind
or character to purchase or otherwise to acquire from VHL any shares of its
capital stock or any other security, and no security or obligation of any kind
convertible into the capital stock or other security of VHL exists in favor of
any person, corporation, partnership, trust, incorporated or unincorporated
association, joint venture, joint stock company, government (or any agency or
political subdivision thereof) or other entity of any kind ("Person").

     2.3 Subsidiaries. VPI (UK) Ltd., incorporated in England, VPI Gesellschaft
fur die Entwicklung und Synthese von Oligomeren mbH, organized in Germany, and
Ribonetics GmbH Gesellschaft fur molekulare Therapie, organized in Germany, are
wholly-owned subsidiaries of VHL (collectively, the "Subsidiaries" and
individually, a "Subsidiary") and the only subsidiaries of VHL. Each Subsidiary
has been duly organized and is validly existing and in good standing under the
laws of its respective jurisdiction of organization, with full corporate power
and authority to own, lease and operate its respective properties, no Subsidiary
is required to qualify to do business in the United States, and there are no
outstanding rights, subscriptions, warrants, calls, preemptive rights, options
or other agreements or commitments of any kind or character to purchase or
otherwise to acquire from any Subsidiary any shares of its capital stock or any
other security, and no security or obligation of any kind convertible into the
capital stock or other security of any Subsidiary exists in favor of any Person.

     2.4 Articles of Incorporation, By-Laws and Corporate Records. The copies of
the Certificate of Incorporation, By-Laws, stock transfer, minute books and
corporate records of VHL and the copies of the Memorandum of Association and/or

                                       2

<PAGE>


organizational documents of each Subsidiary, which have been made available to
Innovir, are true and correct copies.

     2.5 Governmental Authorizations and Other Consents. Except as set forth on
Schedule 2.5, no consent, order, license, approval or authorization of, or
exemption by, or registration or declaration or filing with, any governmental
authority, bureau or agency, and no consent or approval of any other Person, is
required to be obtained or made in connection with the performance by VIMRx
and/or VHL or any Subsidiary of this Agreement or the consummation of the
transactions contemplated to be performed by each of them hereunder.

     2.6 Non-Contravention. Except as set forth on Schedule 2.6, the performance
of this Agreement will not (i) violate any provision of the Certificate of
Incorporation or By-Laws of VIMRx or VHL or the equivalent organizational
documents of any Subsidiary; (ii) violate, conflict with or result in the breach
or termination of, or constitute an amendment to, or otherwise give any Person
the right to terminate, or constitute (or with notice or lapse of time or both
would constitute) a default (by way of substitution, novation or otherwise)
under the terms of, any contract, mortgage, lease, bond, indenture, agreement,
franchise or other instrument or obligation to which VHL or any Subsidiary is a
party or by which VHL or any Subsidiary or any of their respective assets or
properties are bound or affected; (iii) result in the creation of any lien,
mortgage, claim, charge, security interest, encumbrance, restriction or
limitation (collectively, "Liens") upon the properties or assets of VHL or any
Subsidiary pursuant to the terms of any contract, mortgage, lease, bond,
indenture, agreement, franchise or other instrument or obligation; (iv) violate
any judgment, order, injunction, decree or award of any court, arbitrator,
administrative agency or governmental or regulatory body against, or binding
upon, VHL or any Subsidiary or any of their respective securities, properties,
assets or business; (v) constitute a violation by VHL or any Subsidiary of any
statute, law, rule or regulation of any jurisdiction as such statute, law, rule
or regulation relates to VHL or any Subsidiary or to any of their respective
securities, properties, assets or business; or (vi) violate any Permit (as
defined in Section 2.14).

     2.7 Financial Statements. The unaudited balance sheet of VHL and its
Subsidiaries as at September 30, 1996 (the "September 30, 1996 Balance Sheet")
and the related unaudited statement of income for the nine months then ended
(together with the September 30, 1996 Balance Sheet, the "September 30, 1996
Financial Statements"), together with the balance sheet of VHL and its
Subsidiaries as at December 31, 1995 (the "December 31, 1995 Balance Sheet") and
the related statements of income, capital and cash flows for each of the years
from inception through December 31, 1995 audited by independent certified public
accountants (the "Audited Financial Statements") to be delivered to Innovir
prior to the Closing Date will be prepared in accordance with generally accepted
accounting principles ("GAAP")

                                       3

<PAGE>


consistently applied, be true and correct and present fairly the financial
condition and the results of operations and cash flows of VHL and its
Subsidiaries as at the respective dates and for the respective periods covered
thereby.

     2.8 Tangible Property. VHL and the Subsidiaries have good and marketable
title to all of the assets reflected on the September 30, 1996 Balance Sheet,
free and clear of all Liens, except for those assets leased under leases listed
on Schedule 2.8.

     2.9 Real Property and Leases. (a) VHL and the Subsidiaries own no real
property.

     (b) Schedule 2.9(b) sets forth a true and correct list of all leases,
subleases or other agreements under which VHL or any Subsidiary is lessee or
lessor of any real property or has any interest in real property and, except as
set forth in Schedule 2.9(b), there are no rights or options held by VHL or any
Subsidiary or any contractual obligations to purchase or otherwise acquire
(including by way of lease or sublease) any interest in or use of any real
property, nor any rights or options granted by VHL or any Subsidiary, or any
contractual obligations to sell or otherwise dispose of (including by way of
lease or sublease) any interest in or use of any real property. All such leases,
subleases and other agreements are in full force and effect and constitute
legal, valid and binding obligations of the respective parties thereto, with no
existing or claimed default or event of default, or event which with notice or
lapse of time or both would constitute a default or event of default, by VHL,
any Subsidiary or, to the knowledge of VIMRx, by any other party thereto, which
would materially and adversely affect VHL or any Subsidiary, and grant the
leasehold estates or other interests they purport to grant with the right to
quiet possession. VHL and the Subsidiaries are not in violation of any building,
zoning, health, safety, environmental or other law, rule or regulation and no
notice from any Person has been served upon VHL or any Subsidiary claiming any
such violation.

     2.10 Intellectual Property. Schedule 2.10 sets forth (i) all trademarks,
trade names, trade secrets, patents, inventions, processes, copyrights,
copyright rights or other intellectual property rights (or applications
therefor) used by VHL and the Subsidiaries in connection with their respective
business, (ii) whether such property is owned, licensed or leased, and (iii) a
summary of the terms of the license or lease. VHL has not made any commercial
sale of synthetic catalytic oligonucleotides in the United States through the
date hereof.

     2.11 Tax Matters. VHL and the Subsidiaries have timely filed all applicable
tax returns, estimates and reports (collectively, "Returns") required to be
filed by them through the date hereof, copies of which have been delivered to
Innovir, which Returns accurately reflect the taxes, if any, due for the periods
indicated, and have paid in full all income, gross receipts, value added,
excise, property, franchise, sales, use, employment, payroll and other taxes of
any kind whatsoever (collectively,

                                       4

<PAGE>


"Taxes") shown to be due by such Returns, and have established adequate reserves
with respect to any liabilities for Taxes accrued through December 31, 1995
which are reflected on the December 31, 1995 Balance Sheet and VIMRx has no
knowledge of any unassessed deficiency for Taxes proposed or threatened against
VHL and the Subsidiaries, and no taxing authority has raised any issue which, if
adversely determined, would result in a liability for any Tax which has not been
reserved against on the December 31, 1995 Balance Sheet. No extensions with
respect to the dates on which any Return was or is due to be filed by VHL or any
Subsidiary nor any waivers or agreements by VHL and the Subsidiaries for the
extension of time for the assessment or payment of any Taxes are in force.
Neither VHL nor any Subsidiary has been, nor currently is being, audited by any
tax authority.

     2.12 Compliance with Laws. VHL and the Subsidiaries are not in violation of
any applicable law, rule or regulation, the violation of which could materially
and adversely affect their assets, properties, liabilities, business, results of
operations, condition (financial or otherwise) or prospects, nor does VIMRx know
of the enactment, promulgation or adoption of any such law, rule or regulation
which is not yet effective.

     2.13 Permits and Licenses. Except as set forth on Schedule 2.13, VHL and
the Subsidiaries have duly obtained and hold in full force and effect all
consents, authorizations, permits, licenses, orders or approvals of, and has
made all declarations and filings with, all federal, state or local governmental
or regulatory bodies that are material or necessary in the conduct of their
respective business (collectively, the "Permits"); all the Permits were duly
obtained and are in full force and effect; no violations are or have been
recorded in respect of any such Permit and no proceeding is pending or
threatened to revoke, deny or limit any such Permit.

     2.14 Contracts and Agreements. Schedule 2.14 lists and briefly describes
all written or oral contracts, agreements, leases, mortgages and commitments to
which VHL or any Subsidiary is a party or by which any of them may be bound
involving in excess of $25,000, including, without limitation, all collaboration
agreements, management agreements, joint venture agreements, leases, guarantees
and indemnifications, employment and consulting agreements and instruments of
indebtedness (individually, a "Contract" and, collectively, "Contracts"), true
and correct copies of which have been made available to Innovir. All Contracts
constitute legal, valid and binding obligations of VHL or the Subsidiaries and,
to the best knowledge of VIMRx, of the other parties thereto, and are in full
force and effect on the date hereof, and VHL or the Subsidiaries have paid in
full all amounts due thereunder which are due and payable and are not in default
under any such Contract nor, to the best knowledge of VIMRx, is any other party
to any such Contract in default thereunder, nor does any condition exist that
with notice or lapse of time or both would constitute a default or event of
default thereunder by VHL or the Subsidiaries or, to the best knowledge of
VIMRx, by any other Person. Except as set forth in Schedule 2.5, no Contract
requires the consent or approval of a third party

                                       5

<PAGE>


in connection with the performance by VHL or any Subsidiary of this Agreement or
the transactions contemplated to be performed by it hereunder.

     2.15 Employee Benefits. Except as set forth on Schedule 2.15, there are no
pension, retirement, savings, disability, medical, dental or other health plans,
life insurance (including any individual life insurance policy as to which VHL
or any Subsidiary makes premium payments whether or not VHL or the Subsidiary is
the owner, beneficiary, or both, of such policy) or other death benefit plans,
profit sharing, deferred compensation, stock option, bonus or other incentive
plans, vacation benefit plans, severance plans, or other employee benefit plans
or arrangements (whether written or arising from custom).

     2.16 Accounts Payable. Except as set forth on Schedule 2.16, no accounts
payable of VHL or any Subsidiary have arisen subsequent to September 30, 1996
that exceed $10,000 for any one payee or $25,000 in the aggregate.

     2.17 Liabilities. There are no material liabilities or obligations of VHL
and the Subsidiaries either accrued, absolute, contingent or otherwise
("Liabilities"), whether or not of a kind required by GAAP to be set forth on a
financial statement, except (i) those accrued, reflected or otherwise provided
for on the September 30, 1996 Balance Sheet furnished to Innovir, (ii) those
incurred in the ordinary course of business since September 30, 1996, consistent
with past practices, and which in the aggregate do not exceed $25,000 and (iii)
those listed on Schedule 2.17.

     2.18 Actions and Proceedings. Except as set forth on Schedule 2.18, there
are no claims, actions, suits, arbitrations, proceedings, investigations or
inquiries, whether at law or in equity and whether or not before any court,
private body or group, governmental department, commission, board, agency or
instrumentality (collectively, "Actions"), pending, or to the knowledge of
VIMRx, threatened against, involving or affecting VHL, any Subsidiary or any of
their respective assets, whether or not fully or partially covered by insurance,
or which would give rise to any right of indemnification by any Person from VHL
or any Subsidiary, and there are no outstanding orders, writs, injunctions,
awards, sentences or decrees of any court, private body or group, governmental
department, commission, board, agency or instrumentality against, involving or
affecting VHL or any Subsidiary or their respective assets or business.

     2.19 Bank Accounts, Guarantees and Powers. Schedule 2.19 sets forth (i) a
list of all accounts, borrowing resolutions and deposit boxes maintained by VHL
and each Subsidiary at any bank or other financial institution and the names of
the persons authorized to effect transactions in such accounts, to borrow
pursuant to such resolutions and with access to such boxes; (ii) all agreements
or commitments of VHL and each Subsidiary guaranteeing the payment of money or
the performance of other contracts by any third persons; and (iii) the names of
all Persons holding

                                       6

<PAGE>


general or special powers of attorney from VHL or a Subsidiary, together with a
summary of the terms thereof.

     2.20 Absence of Changes. Except as set forth in Schedule 2.20, since
September 30, 1996, VHL and the Subsidiaries have carried on their respective
business in the ordinary course, and there has not been:

          (i) any material adverse change in their respective business condition
     (financial or otherwise), results of operations or liabilities;

          (ii) any pending or threatened amendment, modification, or termination
     of any agreement or Permit which is material to their respective business;

          (iii) any disposition or acquisition of any of their respective assets
     or properties, other than in the ordinary course, which exceed $2,500 in
     the aggregate;

          (iv) any damage, destruction or other casualty loss (whether or not
     covered by insurance) adversely affecting or that could reasonably be
     expected to adversely affect their respective business or assets;

          (v) any increase in the compensation of any of their respective
     employees or consultants; or

          (vi) except in the ordinary course, the incurrence of any obligation
     or liability (whether matured, unmatured, absolute, accrued, contingent or
     otherwise) which exceed $2,500 in the aggregate.

     2.21 Employee Relations. VHL and the Subsidiaries have not at any time
during the last five years had, or to the knowledge of VIMRx is there now
threatened, a strike, picket, work stoppage, work slowdown, or other labor
trouble or dispute, and VIMRx has no knowledge of the proposed resignation of
any employee of VHL or any Subsidiary whose annual salary exceeds $25,000.

     2.22 Affiliated Transactions. For purposes of this Section, an "Affiliate"
means VIMRx or any employee, officer or director of VHL or any Subsidiary or any
spouse or family member (including in-laws) of, or any corporation or other
entity "controlled by" (as such term is defined in Rule 405 of the General Rules
and Regulations under the Securities Act of 1993, as amended), any such persons
or in which any such person has an equity or ownership interest exceeding five
percent.

                                       7

<PAGE>


     (a) Except as specifically set forth (including dollar amounts) on Schedule
2.22, as of the date hereof, no Affiliate is indebted to, or is a creditor of,
VHL or any Subsidiary.

     (b) During the past three (3) years, except as set forth on Schedule 2.22
neither VHL nor any Subsidiary has, directly or indirectly, purchased, leased
from or otherwise acquired any property or obtained any services from, or sold,
leased to or otherwise disposed of any property or furnished any services to, or
otherwise dealt with, any Affiliate nor is VHL or any Subsidiary a party to any
contract, agreement, license, commitment or other arrangement, written or oral,
express or implied, with an Affiliate except as disclosed on such schedule.

     2.23 Brokers' Fees. There is no broker, finder or other intermediary
retained by VIMRx, VHL or any Subsidiary who might be entitled to a fee or
commission in connection with the transactions contemplated hereby.

     2.24 Full Disclosure. All documents, schedules, financial statements and
other materials delivered or made available by or on behalf of VIMRx or VHL or
any Subsidiary to Innovir in connection with this Agreement and the transactions
contemplated hereby are true and correct in all material respects. The
information furnished to Innovir by or on behalf of VIMRx, VHL or any Subsidiary
in connection with this Agreement and the transactions contemplated hereby does
not, in light of the circumstances under which the statements contained in the
information so furnished were made, contain any untrue statement of a material
fact or omit to state any material fact necessary to make the statements
contained therein not false or misleading.

     2.25 Employee Compensation. Schedule 2.25 lists all employees of VHL and
each Subsidiary, setting forth their respective annual salaries, whether they
are employed under contract or at will, and the expiration date of each
contract.

     2.26 Authority. This Agreement has been duly executed and delivered by
VIMRx and is a valid and binding agreement of VIMRx enforceable against VIMRx in
accordance with its terms, except as may be limited by applicable bankruptcy,
insolvency or similar laws affecting creditors' rights generally or the
availability of equitable remedies.

     2.27 Title to the VHL Shares. VIMRx owns the VHL Shares, free and clear of
all Liens and, upon delivery to Innovir of the certificates therefor duly
endorsed for transfer to Innovir, Innovir will acquire good, valid, indefeasible
and marketable title thereto, free and clear of any and all Liens.

     2.28 Examination of Documents, Investment Purposes and Legending of Innovir
Shares and Innovir Warrants. VIMRx has examined the Annual Report on

                                       8

<PAGE>


Form 10-K of Innovir for the fiscal year ended September 30, 1995 (the "1995
Form 10-K"), Innovir's Quarterly Reports on Form 10-Q for the quarters ended
December 31, 1995, March 31, 1996 and June 30, 1996, Innovir's Proxy Statement
for its 1994 Annual Meeting of Stockholders and Innovir's 1994 Annual Report to
Stockholders, has had the opportunity to discuss Innovir's operations with
Innovir's officers and employees, and is acquiring the Innovir Shares and the
Innovir Warrants for its own account for investment within the contemplation of
the Securities Act of 1933, as amended (the "Securities Act") and not with a
view to the transfer or resale thereof, and consents to the legending of the
certificates for the Innovir Shares to be received with a legend in
substantially the following form:

                  "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE
                  NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
                  1933, AS AMENDED (THE "ACT") AND MAY NOT BE SOLD,
                  TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN
                  EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT
                  FOR THESE SHARES OR AN OPINION OF INNOVIR'S
                  COUNSEL THAT REGISTRATION IS NOT REQUIRED",

and to the affixation of a similar legend on the Innovir Warrants.

     2.29 Insurance. Schedule 2.29 contains a list of all insurance policies
covering the respective assets, businesses, operations, employees, officers and
directors of VHL and each Subsidiary, and the dates through which each such
policy is effective. Each such policy is in full force and effect and evidence
of the effectiveness of each such policy has been delivered to Innovir. Except
as set forth in Schedule 2.29, there is no claim by VHL or any Subsidiary
pending under any of such policies as to which coverage has been questioned,
denied or disputed by the underwriters of such policies. All premiums payable
under such policies have been paid, and VHL and each Subsidiary is otherwise in
full compliance with the terms and conditions of such policies. Such policies
are of the types and in the amounts customarily carried by Persons conducting
businesses similar to those of VHL and the Subsidiaries. Neither VIMRx, VHL nor
any Subsidiary has any knowledge of any threatened termination of any of such
policies.

     2.30 Environmental. VHL and each Subsidiary currently operates, and at all
times in the past has operated, in compliance with all applicable laws,
statutes, codes, ordinances, rules, regulations, or other requirements relating
to the protection of human health and safety, the environment, or hazardous or
toxic substances or waste, pollutants or contaminants ("Environmental Laws").
None of VIMRx, VHL or any Subsidiary has received any notification of any
present or past failure on the part of VHL or any Subsidiary to comply with any
applicable Environmental Laws. No Lien has attached to, and no basis exists for
the attachment of any Lien to, any revenues of VHL or any Subsidiary or their
respective assets pursuant to any Environmental

                                       9

<PAGE>


Laws. There has not been any Phase I, Phase II or other environmental report
conducted by or on behalf of VHL or any Subsidiary with respect to their
respective properties or assets.

                                    ARTICLE 3

                    REPRESENTATIONS AND WARRANTIES OF INNOVIR

     Innovir represents and warrants to VIMRx that:

     3.1 Organization. Innovir is a corporation duly organized, validly existing
and in good standing under the laws of the State of Delaware, has all requisite
corporate power and authority to own, lease and operate its properties and to
carry on its business as now being conducted, and is duly qualified and licensed
as a foreign corporation to transact business and is in good standing in each
jurisdiction in which it is required to be so qualified or authorized.

     3.2 Authority and Consent. This Agreement has been duly authorized,
executed and delivered by Innovir and is a valid and binding agreement of
Innovir enforceable against Innovir in accordance with its terms, except as may
be limited by applicable bankruptcy, insolvency or similar laws affecting
creditors' rights generally or the availability of equitable remedies and no
consent or approval is required of any Person in connection with the performance
by Innovir of this Agreement or the consummation by Innovir of the transactions
contemplated hereby.

     3.3 Non-Contravention. Except as set forth on Schedule 3.3, the performance
of this Agreement by Innovir will not (i) violate any provision of its
Certificate of Incorporation or By-Laws; (ii) violate, conflict with or result
in the breach or termination of, or constitute an amendment to, or otherwise
give any Person the right to terminate, or constitute (or with notice or lapse
of time or both would constitute) a default (by way of substitution, novation or
otherwise) under the terms of, any contract, mortgage, lease, bond, indenture,
agreement, franchise or other instrument or obligation to which Innovir is a
party or by which it or any of its assets or properties are bound or affected;
(iii) result in the creation of any Liens upon the properties or assets of
Innovir pursuant to the terms of any contract, mortgage, lease, bond, indenture,
agreement, franchise or other instrument or obligation; (iv) violate any
judgment, order, injunction, decree or award of any court, arbitrator,
administrative agency or governmental or regulatory body against, or binding
upon, Innovir or any of its securities, properties, assets or business; (v)
constitute a violation by Innovir of any statute, law, rule or regulation of any
jurisdiction as such statute, law, rule or regulation relates to Innovir or to
any of its securities, properties, assets or business; (vi) violate any Permit
(as defined in Section 2.13); or (vi) result in an adjustment to the conversion
or exercise price of any of Innovir's outstanding securities.

                                       10

<PAGE>


     3.4 Capitalization. Innovir's authorized capital stock consists of (i)
15,000,000 shares of preferred stock, of which 297,000 shares of Class B
Convertible Preferred Stock and 20,000 shares of Class C Convertible Preferred
Stock are issued and outstanding, and (ii) 35,000,000 shares of Common Stock, of
which 11,780,646 shares are issued and outstanding, 14,616,500 shares are
reserved for issuance upon exercise of warrants (8,000,000 shares at a price of
$.50 per share and 6,616,500 shares at prices ranging from $0.05 per share to
$10.67 per share and averaging $5.07 per share), 1,646,625 shares are reserved
for issuance upon exercise of outstanding employee stock options at prices
ranging from $0.97 per share to $12.00 per share and averaging $4.21 per share,
629,289 shares are reserved for issuance upon conversion of convertible
preferred stock and 519,736 shares are reserved for future option grants under
Innovir's stock option plan.

     3.5 Intellectual Property. Schedule 3.5 sets forth (i) all trademarks,
trade names, trade secrets, patents, inventions, processes, copyrights,
copyright rights or other intellectual property rights (or applications
therefor) used by Innovir in connection with its business, (ii) whether such
property is owned, licensed or leased, and (iii) a summary of the terms of the
license or lease.

     3.6 Actions and Proceedings. Except as set forth on Schedule 3.6, there are
no Actions pending, or to the knowledge of Innovir threatened against, involving
or affecting Innovir or any of its assets, whether or not fully or partially
covered by insurance or which would give rise to any right of indemnification by
any Person from Innovir, and there are no outstanding orders, writs,
injunctions, awards, sentences or decrees of any court, private body or group,
governmental department, commission, board, agency or instrumentality against,
involving or affecting Innovir, its assets or business.

     3.7 Absence of Changes. Except as set forth in Schedule 3.7, since
September 30, 1996, Innovir has carried on its business in the ordinary course,
and there has not been:

          (i) any material adverse change in its business condition (financial
     or otherwise), results of operations or liabilities;

          (ii) any pending or threatened amendment, modification, or termination
     of any agreement or Permit which is material to its business;

          (iii) any disposition or acquisition of any of its assets or
     properties, other than in the ordinary course, which exceed $2,500 in the
     aggregate;

                                       11

<PAGE>


          (iv) any damage, destruction or other casualty loss (whether or not
     covered by insurance) adversely affecting or that could reasonably be
     expected to adversely affect its business or assets;

          (v) any modification to any existing, or the adoption or entrance into
     any new, employee benefit plan, employment agreement or consulting
     agreement, or the increase in the compensation of any of its employees or
     consultants; or

          (vi) except in the ordinary course, the incurrence of any obligation
     or liability (whether matured, unmatured, absolute, accrued, contingent or
     otherwise) which exceed $2,500 in the aggregate.

     3.8 The Innovir Shares. The Innovir Shares to be delivered hereby, when
issued and delivered in accordance with the terms of this Agreement, will be
validly issued, fully paid and non-assessable and will conform to the terms
thereof set forth on Schedule 3.8 and, following the increase of Innovir's
authorized Common Stock to 70,000,000 shares, the shares of Innovir's Common
Stock issuable upon conversion thereof will be duly reserved for issuance and,
when issued upon such conversion, will be validly issued, fully paid and
non-assessable.

     3.9 The Innovir Warrants. The Innovir Warrants to be delivered hereby, when
issued and delivered in accordance with the terms of this Agreement, will be
duly authorized and executed, will conform to the terms thereof set forth on
Schedule 3.9 and will constitute valid and legally binding obligations of
Innovir, enforceable in accordance with their terms and, following the increase
of Innovir's authorized Common Stock to 70,000,000 shares, the shares of
Innovir's Common Stock issuable upon exercise thereof will be duly reserved for
issuance and, when issued upon such exercise, will be validly issued, fully paid
and non-assessable.

     3.10 Investment Purposes. Innovir is acquiring the VHL Shares for its own
account for investment within the contemplation of the Securities Act and not
with a view to the transfer or resale thereof.

     3.11 Documents Delivered. Innovir has delivered to VIMRx, Innovir's (i)
Annual Report on Form 10-K for its fiscal year ended September 30, 1995 (ii)
Quarterly Reports on Form 10-Q for the quarters ended December 31, 1995, March
31, 1996 and June 30, 1996 (iii) Proxy Statement for its 1994 Annual Meeting of
Stockholders and (iv) its Prospectus dated October 8, 1996 and the related
Registration Statement on Form S-3 (collectively, the "SEC Documents"). The SEC
Documents, including the financial statements included therein, complied as to
form

                                       12

<PAGE>


with the requirements of the Securities Exchange Act of 1934, as amended and the
rules and regulations thereunder (and, with respect to the Registration
Statement on Form S-3, the Securities Act), were true and complete in all
material respects as at their respective dates, and did not contain any untrue
statement of a material fact nor omit to state any material fact required to be
stated therein or necessary to make the statements contained therein, in light
of the circumstances under which they were made, not misleading. The unaudited
financial statements of Innovir as at September 30, 1996 and for the three years
then ended delivered to VIMRx have been prepared in accordance with GAAP
consistently applied, are true and correct and present fairly the financial
condition and the results of operations and cash flows of Innovir as at the
respective dates and for the respective periods covered thereby, except as
disclosed in Schedule 3.11.

                                    ARTICLE 4

               CONDUCT PENDING CLOSING BY VHL AND THE SUBSIDIARIES

     From the date hereof and until the Closing Date, except as otherwise
provided by this Agreement or as agreed by Innovir in writing, VIMRx hereby
covenants and agrees that it shall cause VHL and each Subsidiary to comply with
each of the following covenants:

     4.1 Conduct of Business. To conduct its business in the ordinary course
consistent with past practice, maintain adequate insurance, preserve intact its
business organization and employees, maintain satisfactory relationships with
its independent agents, and others having business relationships with it,
maintain its books and records in its usual manner and not make any change in
its financial reporting, or accounting practices or policies, or in its
reserving practices or policies.

     4.2 Certain Prohibited Activities. Not to (i) issue, sell or deliver, or
agree to issue, sell or deliver, any shares of its capital stock or any other
security (whether authorized and unissued or held as treasury shares), or grant
or issue, or agree to grant or issue, any subscription, option, warrant or other
right calling for the issue, sale or delivery thereof; (ii) declare or pay any
dividend or distribution on any shares of its capital stock; (iii) purchase,
redeem or otherwise acquire any shares of its capital stock; (iv) make any
change in any pension or employee benefit plan or arrangement, or any collective
bargaining agreement, or enter into, amend, modify or terminate any arrangement
or agreement with any officer, director, employee, independent contractor,
representative; (v) create, incur, assume or guarantee any indebtedness for
borrowed money; (vi) make any capital expenditure, or purchase, lease or license
any real or personal property which exceed $2,500 in the aggregate; (vii) sell
or otherwise dispose of or pledge any of its assets (tangible or intangible) or
cancel any debts or claims (including, without limitation, accounts receivable)
owing to it, except in the ordinary course of business which does not otherwise
violate this

                                       13

<PAGE>


Agreement; (viii) merge or consolidate with any other Person or acquire control
of all or any substantial portion of the assets of any other Person or take any
steps incident to, or in furtherance of, merging or consolidating with or
acquiring control of all or any substantial portion of the assets of any other
Person, whether by entering into an agreement providing therefor or otherwise;
(ix) make or cause to be made any alteration in the manner of keeping its books,
accounts or records or in the accounting practices and principles therein and
theretofore reflected, except as required by law; (x) effect or agree to any
change in its articles or similar instruments of organization (except that VHL
is discontinuing in the Islands of Bermuda and domesticating in the State of
Delaware) or By-Laws; (xi) settle or agree to settle any claim, action, suit or
proceeding involving the payment or receipt of more than $5,000, individually,
or $10,000, in the aggregate; (xii) enter into any other transaction or
agreement which is not in the ordinary and usual course of business; or (xiii)
agree or commit to do any of the foregoing.

     4.3 Reports; Taxes; Etc. To duly and timely file, or cause to be duly and
timely filed, all filings, declarations, reports or returns required to be filed
with governmental authorities and to promptly pay all taxes, assessments and
governmental charges lawfully levied or assessed.

     4.4 Access to Information. To afford Innovir, its counsel, financial
advisors, auditors and other authorized representatives full access, upon
reasonable prior notice and during normal business hours, to its offices,
properties, books and records and to its employees, agents and independent
accountants, and to furnish to Innovir, its counsel, financial advisors,
auditors and other authorized representatives such financial and operating data
and other information as may reasonably be requested, and to instruct its
employees, counsel and financial advisors to cooperate with Innovir in Innovir's
due diligence.

     4.5 Further Assurances. To do or cause to be done such further acts and
things and deliver or cause to be delivered to Innovir such additional
assignments, agreements, powers and instruments as Innovir may reasonably
require or deem reasonably advisable to carry into effect the purposes of this
Agreement or the other agreements to be entered into in connection with the
transactions contemplated hereby or to better assure and confirm the rights,
powers and remedies of Innovir hereunder and thereunder.

     4.6 Tax Adjustments. To promptly notify Innovir of all proposed adjustments
contained in examination reports received from any tax authority to any Return
relating to adjustment for tax years prior to and including the Closing Date
which could materially adversely affect VHL, any Subsidiary or Innovir and to
provide Innovir and its representatives such information and records as they may
reasonably request with respect to such adjustments. Innovir shall have the
right to participate in and pay its own expenses relating to the contest of all
such proposed adjustments

                                       14

<PAGE>


which might adversely affect Innovir by the creation of adverse precedent or
otherwise.

     4.7 Governmental Notification and Approvals. To prepare promptly, file and
diligently pursue with the appropriate governmental agencies all documentation
and information required by law or requested by each such agency to be filed to
permit the consummation of the transactions contemplated hereby.

                                    ARTICLE 5

                       CONDUCT PENDING CLOSING BY INNOVIR

     From the date hereof and until the Closing Date, except as otherwise
provided by this Agreement or as agreed by VIMRx in writing, Innovir hereby
covenants and agrees, as follows:

     5.1 Conduct of Business. To conduct its business in the ordinary course
consistent with past practice, maintain adequate insurance, preserve intact its
business organization and employees, maintain satisfactory relationships with
its independent agents, and others having business relationships with it,
maintain its books and records in its usual manner and not make any change in
its financial reporting, or accounting practices or policies, or in its
reserving practices or policies.

     5.2 Certain Prohibited Activities. Not to (i) issue, sell or deliver, or
agree to issue, sell or deliver, any shares of its capital stock or any other
security (whether authorized and unissued or held as treasury shares), other
than upon the exercise of outstanding options or warrants or upon conversion of
outstanding preferred stock, or grant or issue, or agree to grant or issue, any
subscription, option, warrant or other right calling for the issue, sale or
delivery thereof, except that Innovir may grant (x) new employee stock options
to purchase Innovir's Common Stock at $1.30 per share in replacement of existing
employee stock options and to employees who have not theretofore been granted
options, all such grants of stock options being substantially in accordance with
Schedule 5.2, with new vesting provisions approved by VIMRx and provided that
such vesting provisions do not accelerate upon the consummation of the
transactions herein provided and (y) warrants to purchase 20,000 shares of
Innovir's Common Stock at $1.50 per share to New York State Science and
Technology Foundation, (ii) declare or pay any dividend or distribution on any
shares of its capital stock; (iii) purchase, redeem or otherwise acquire any
shares of its capital stock; (iv) make any change in any pension or employee
benefit plan or arrangement, or any collective bargaining agreement, or enter
into, amend, modify or terminate any arrangement or agreement with any officer,
director, employee, independent contractor, representative; (v) create, incur,
assume or guarantee any indebtedness for borrowed money; (vi) make any capital
expenditure, or purchase, lease or license any real or personal property which
exceed $2,500 in the aggregate;

                                       15

<PAGE>


(vii) sell or otherwise dispose of or pledge any of its assets (tangible or
intangible) or cancel any debts or claims (including, without limitation,
accounts receivable) owing to it, except in the ordinary course of business
which does not otherwise violate this Agreement; (viii) merge or consolidate
with any other Person or acquire control of all or any substantial portion of
the assets of any other Person or take any steps incident to, or in furtherance
of, merging or consolidating with or acquiring control of all or any substantial
portion of the assets of any other Person, whether by entering into an agreement
providing therefor or otherwise; (ix) make or cause to be made any alteration in
the manner of keeping its books, accounts or records or in the accounting
practices and principles therein and theretofore reflected, except as required
by law; (x) effect or agree to any change in its Certificate of Incorporation or
By-laws; (xi) settle or agree to settle any claim, action, suit or proceeding
involving the payment or receipt of more than $5,000, individually, or $10,000,
in the aggregate; (xii) enter into any other transaction or agreement which is
not in the ordinary and usual course of business; or (xiii) agree or commit to
do any of the foregoing.

     5.3 Reports; Taxes; Etc. To duly and timely file, or cause to be duly and
timely filed, all filings, declarations, reports or returns required to be filed
with governmental authorities and to promptly pay all taxes, assessments and
governmental charges lawfully levied or assessed.

     5.4 Access to Information. To afford VIMRx, its counsel, financial
advisors, auditors and other authorized representatives full access, upon
reasonable prior notice and during normal business hours, to its offices,
properties, books and records and to its employees, agents and independent
accountants, and to furnish VIMRx, its counsel, financial advisors, auditors and
other authorized representatives such financial and operating data and other
information as may reasonably be requested, and to instruct its employees,
counsel and financial advisors to cooperate with VIMRx in VIMRx's due diligence.

     5.5 Further Assurances. To do or cause to be done such further acts and
things and deliver or cause to be delivered to VIMRx such additional
assignments, agreements, powers and instruments as VIMRx may reasonably require
or deem reasonably advisable to carry into effect the purposes of this Agreement
or the other agreements to be entered into in connection with the transactions
contemplated hereby or to better assure and confirm the rights, powers and
remedies of VIMRx hereunder and thereunder.

     5.6 Tax Adjustments. To promptly notify VIMRx of all proposed adjustments
contained in examination reports received from any tax authority to any Return
relating to adjustment for tax years prior to and including the Closing Date
which could materially adversely affect Innovir and to provide VIMRx and its
representatives such information and records as they may reasonably request with
respect to such adjustments.

                                       16

<PAGE>


     5.7 Governmental Notification and Approvals. To prepare promptly, file and
diligently pursue with the appropriate governmental agencies all documentation
and information required by law or requested by each such agency to be filed to
permit the consummation of the transactions contemplated hereby.


                                    ARTICLE 6

                         COVENANTS OF VIMRx AND INNOVIR

     VIMRx and Innovir hereby severally covenant and agree:

     6.1 Necessary Assurances. To take, or cause to be taken, all actions and to
do, or cause to be done, all things reasonably necessary or desirable under
applicable laws and regulations to consummate the transactions contemplated by
this Agreement expeditiously, including executing and delivering such further
documents, certificates, applications and agreements as reasonably may be
necessary or desirable.

     6.2 Filings and Consents. To cooperate (i) with respect to any filing with
any governmental body, agency, official or authority required in connection with
this Agreement or the consummation of the transactions contemplated hereby and
(ii) with respect to any actions, consents, approvals or waivers required to be
obtained from parties to any material contracts in connection with this
Agreement or the consummation of the transactions contemplated hereby.

     6.3 Government Filings. To make any and all filings required to be made
with any and all governmental authorities in connection with the consummation of
the transactions contemplated herein, including, if required, the notification
required by the Hart-Scott-Rodino Act (the "HSR" Act) and any requested or
supplementary filings thereto in such manner and at such places as are specified
in the HSR Act and the applicable rules and regulations thereunder, and any
other notifications to, or filings with, regulatory authorities. Innovir shall
pay the fee due in connection with the filing, if required, of the notification
required under the HSR Act; provided, however, that Innovir shall not be
required to pay such fee in the event that such notification relates only to the
transaction between Aries and VIMRx referred to in clause (ii) of Section 9.1
hereof.

     6.4 Public Announcements. To consult with each other before issuing any
press release or otherwise making any public statement with respect to the
transactions contemplated by this Agreement and not to issue any such press
release or make any such public statement without the prior approval of the
other party, except as may be required by any applicable law, rule, regulation
or regulatory agency requirement.


                                       17



<PAGE>


     6.5 Confidentiality. To treat as confidential all information concerning
Innovir (in the case of VIMRx, VHL and the Subsidiaries) and VIMRx, VHL and the
Subsidiaries (in the case of Innovir) provided in connection with the
transactions contemplated hereby, except to the extent that such information was
in the public domain, prior to the provision thereof to the other party or
thereafter is in the public domain other than through the release, directly or
indirectly, by the party to whom the information was furnished.

     6.6 Expenses. To bear their respective expenses incurred in connection with
the preparation, execution and performance of this Agreement and the transaction
contemplated hereby, including without limitation, all fees and expenses of
their respective legal counsel, financial advisors, auditors and other
representatives.

                                    ARTICLE 7

                              ADDITIONAL COVENANTS

     7.1 VIMRx Covenants. VIMRx hereby covenants and agrees (i) to exercise its
warrants to purchase 1,000,000 shares of Innovir's Common Stock at $1.00 per
share within 30 days after receipt of a written request by the Board of
Directors of Innovir subsequent to May 31, 1997 specifying that Innovir has
insufficient funds to continue its operations past 30 days from the date of the
request, (ii) to pay the costs of the capital equipment ordered and listed on
Schedule 2.20 to the extent any payments are due thereon, and (iii) to vote the
Innovir Shares and its shares of Innovir's Common Stock in favor of the items
specified in sections 7.2 (i) and 7.2 (ii) below.

     7.2 Innovir Covenant. Innovir hereby covenants and agrees, conditional upon
the closing, to convene a meeting of its stockholders to vote upon (i) the
election of five directors, three of whom shall be designees of VIMRx, one of
whom shall not be a VIMRx director, officer or employee, (ii) an amendment to
Innovir's Certificate of Incorporation to increase its authorized Common Stock
to 70,000,000 shares and (iii) such further specified action as Innovir and
VIMRx shall agree.

                                    ARTICLE 8

                              CONDITIONS TO CLOSING

     8.1 Conditions to Obligations of Innovir. The obligations of Innovir
hereunder are conditioned upon the following:

          (a) All warranties and representations of VIMRx contained in this
     Agreement or in any Schedule or instrument delivered hereunder or otherwise


                                       18



<PAGE>


     made in connection with the transactions contemplated hereby shall be true
     and correct on and as of the Closing Date, with the same force and effect
     as if made on and as of the Closing Date.

          (b) VHL and VIMRx shall have performed and complied with all of the
     covenants and agreements required by or pursuant to this Agreement and any
     Schedule or instrument delivered hereunder to be performed or complied with
     on or prior to the Closing Date.

          (c) No suit, action, investigation or proceeding before or by any
     federal or state court or governmental or regulatory authority shall have
     been commenced, and no suit, action or proceeding by any governmental or
     regulatory authority shall have been threatened, against VIMRx, VHL, any
     Subsidiary or Innovir seeking to restrain, prevent or modify the
     transactions contemplated hereby or seeking material damages in connection
     with any of such transactions and no order of any court or administrative
     agency to restrain, prohibit or nullify the consummation of the
     transactions contemplated herein shall be outstanding as of the Closing
     Date.

          (d) All governmental authorities having jurisdiction, to the extent
     required by law, shall have consented to or approved the consummation of
     the transactions contemplated by this Agreement.

          (e) As at the Closing Date, VHL shall have cash and cash equivalents
     of $3,000,000 in excess of its stated liabilities.

          (f) As at the Closing Date, The Aries Fund, A Cayman Island Trust and
     The Aries Domestic Fund, L.P., a Delaware limited partnership
     (collectively, "Aries") shall have exercised warrants to acquire 6,000,000
     shares of Innovir's Common Stock at an aggregate exercise price of
     $3,000,000.

          (g) Receipt of the Audited Financial Statements and the September 30,
     1996 Financial Statements.

          (h) All documents delivered and action taken pursuant hereto shall be
     satisfactory in form and substance to Innovir and its counsel.

     8.2 Conditions to Obligations of VIMRx. The obligations of VIMRx hereunder
are conditioned upon the following:

          (a) All warranties and representations of Innovir contained in this
     Agreement shall be true and correct on and as of the Closing Date with the
     same force and effect as if made on and as of the Closing Date.


                                       19



<PAGE>


          (b) Innovir shall have performed and complied with all of the
     covenants and agreements required by or pursuant to this Agreement and any
     Schedule or instrument delivered hereunder to be performed or complied with
     on or prior to the Closing Date.

          (c) No suit, action, investigation or proceeding before or by any
     federal or state court or governmental or regulatory authority shall have
     been commenced, and no suit, action or proceeding by any governmental or
     regulatory authority shall have been threatened, against VIMRx, VHL, any
     Subsidiary or Innovir seeking to restrain, prevent or modify the
     transactions contemplated hereby or seeking material damages in connection
     with any of such transactions and no order of any court or administrative
     agency to restrain, prohibit, or nullify the consummation of the
     transactions contemplated herein shall be outstanding as of the Closing
     Date.

          (d) All governmental authorities having jurisdiction, to the extent
     required by law, shall have consented to or approved the consummation of
     the transactions contemplated by this Agreement.

          (e) As at the Closing Date, Aries shall have exercised warrants to
     acquire 6,000,000 shares of Innovir's Common Stock at an aggregate exercise
     price of $3,000,000.

          (f) All documents delivered and action taken pursuant hereto shall be
     satisfactory in form and substance to VIMRx and its counsel.


                                    ARTICLE 9

                                     CLOSING

     9.1 Closing Date. The closing of the transactions contemplated by this
Agreement (the "Closing") shall be conditional upon and shall take place
concurrently with the closing of (i) the exercise by Aries of warrants to
purchase 6,000,000 shares of Innovir's Common Stock and (ii) the exchange by
Aries with VIMRx of 9,500,000 shares of Innovir's Common Stock owned by Aries
for VIMRx Common Stock, on December 4, 1996, or such other date as the parties
may fix, (the "Closing Date") at the offices of Epstein Becker & Green, P.C.,
250 Park Avenue, New York, New York 10177-0077.

     9.2 Deliveries by VIMRx. At the Closing, VIMRx shall deliver to Innovir the
following:

          (a) Stock certificates for the VHL Shares, duly endorsed for transfer
     to Innovir or its designee and the stock certificates for the outstanding
     shares of the capital stock of the Subsidiaries.


                                       20



<PAGE>


          (b) The minute book, stock book and stock ledger of VHL and the
     Subsidiaries.

          (c) A copy of the Certificate of Incorporation of VHL, certified by
     the appropriate governmental official having authority therefor.

          (d) An agreement providing for the provision of administrative and
     related services by VIMRx to Innovir and for submission by VIMRx to Innovir
     of potential licenses and other arrangements relating to, but limited to,
     catalytic oligonucleotides, duly executed by VIMRx.

          (e) The written resignations of the directors and officers of VHL and
     the Subsidiaries as requested by Innovir.

          (f) An officers' certificate by the President and the Chief Financial
     Officer of VIMRx confirming as at the Closing Date the correctness of the
     warranties and representations of VIMRx in the agreement and compliance by
     VIMRx and VHL of the covenants and agreements to be performed by them under
     the agreement.

          (g) The opinion of Epstein Becker & Green, P.C., counsel to VIMRx,
     addressed to Innovir, as to Sections 2.1, 2.2, 2.3 (as to due organization
     and subsistence of the Subsidiaries), 2.18, 2.26 and 2.27.

     9.3 Deliveries by Innovir. At the Closing, Innovir shall deliver to VIMRx,
the following:

          (a) Stock certificates for the Innovir Shares and the Innovir Warrants
     registered in the name of VIMRx.

          (b) An officers' certificate by the Chief Executive Officer and the
     Chief Financial Officer of Innovir confirming as at the Closing Date the
     correctness of the warranties and representations of Innovir in the
     agreement and compliance by Innovir of the covenants and agreements to be
     performed by Innovir under the agreement.

          (c) A Secretary's certificate as to (i) the passage of resolutions
     reducing the size of Innovir's Board of Directors to five directors, (ii)
     the receipt and acceptance of written resignations from all directors of
     Innovir, other than Dr. Allan Goldberg and one other director, and (iii)
     the passage of resolutions electing as directors of Innovir Richard L.
     Dunning, David A. Jackson and a third designee of VIMRx who shall not be a
     director, officer or employee of VIMRx or Innovir.


                                       21



<PAGE>


          (d) An agreement providing for the provision of administrative and
     related services by VIMRx to Innovir and for submission by VIMRx to Innovir
     of potential licenses and other arrangements relating to, but limited to,
     catalytic oligonucleotides, duly executed by Innovir.

          (e) The opinion of Fullbright & Jaworski L.L.P., counsel to Innovir,
     addressed to VIMRx, as to Sections 3.1, 3.2, 3.4, 3.6, 3.8, and 3.9.


                                   ARTICLE 10

                                    SURVIVAL

     10.1 Survival. All representations and warranties made in this Agreement
shall survive the delivery of this Agreement and remain in full force and effect
until December 31, 1997.

                                   ARTICLE 11

                                 INDEMNIFICATION

     11.1 Indemnification.

          (a) Indemnification by VIMRx. VIMRx hereby agrees to indemnify and
     hold harmless Innovir from and against any and all losses, liabilities,
     damages, obligations, costs and expenses, including, without limitation,
     amounts paid in settlement and reasonable costs and expenses of
     investigating, preparing to defend and defending any claim, action, suit,
     proceeding, inquiry or investigation in respect thereof (such losses,
     liabilities, damages, obligations, costs and expenses as hereinabove set
     forth, collectively "Damages") incurred by Innovir, resulting from,
     relating to, or arising out of the inaccuracy of any representation or
     warranty herein by VIMRx or the breach of any covenant herein by VIMRx.

          (b) Indemnification by Innovir. Innovir hereby agrees to indemnify and
     hold harmless VIMRx from and against any and all Damages incurred by VIMRx
     resulting from, relating to, or arising out of the inaccuracy of any
     representation or warranty herein by Innovir or the breach of any covenant
     contained herein by Innovir.

          (c) Procedure. If any action, suit, proceeding or claim shall be
     brought against the party to be indemnified by any third party, which
     action, suit, proceeding or claim, if determined adversely to the interest
     of the party to be indemnified and which would entitle the party to be
     indemnified to indemnity pursuant to this Section 11.1, the party to be
     indemnified shall promptly notify the


                                       22



<PAGE>


indemnifying party of the same in writing and, if the indemnifying party so
elects, the indemnifying party shall assume the defense thereof, including the
employment of counsel satisfactory to the party to be indemnified and the
payment of all reasonable costs and expenses in respect thereof. The party to be
indemnified shall have the right to employ counsel separate from any counsel
employed by the indemnifying party in any action, suit, proceeding or claim and
to control (or, if the party to be indemnified has elected to allow the
indemnifying party to assume the defense thereof, participate in) the defense
thereof and the fees and expenses of such counsel employed by the party to be
indemnified shall be at the expense of the party to be indemnified. The
indemnifying party shall not be liable for any settlement of any such action,
suit, proceeding or claim effected without his or its written consent (which
shall not be unreasonably withheld), but if settled with the written consent of
the indemnifying party, or if there shall be a final judgment for plaintiff in
any such action, the indemnifying party agrees to indemnify and hold harmless
the party to be indemnified from and against any loss, liability, obligation,
damage, cost or expense by reason of such settlement or judgment.

                  11.2 Access. In the event that Innovir delivers to VIMRx
notice of a claim for indemnification, Innovir shall provide VIMRx reasonable
access to the books and records of VHL and any Subsidiary (and of Innovir in the
event Innovir has possession of the requisite books and records) with respect to
any matters giving rise to such claim.


                                   ARTICLE 12

                            MISCELLANEOUS PROVISIONS

     12.1 Amendment and Modification. This Agreement may be amended, modified
and supplemented only by a writing signed by Innovir and VIMRx.

     12.2 Waiver of Compliance. Any failure of Innovir or VIMRx to comply with
any obligation, covenant, agreement or condition herein contained may be
expressly waived, in writing only, by (i) Innovir in the case of any failure of
VIMRx or (ii) VIMRx in the case of any failure of Innovir. Such waiver shall be
effective only in the specific instance and for the specific purpose for which
made or given.

     12.3 Notices. All notices, requests, demands and other communications
required or permitted hereunder shall be in writing and shall be deemed to have
been duly given when delivered by hand, or when mailed by certified or
registered mail (return receipt requested), postage prepaid or when delivered by
fax (evidenced by confirmation of successful transmission), as follows:


                                       23



<PAGE>


             A.  If to Innovir:

                 Innovir Laboratories, Inc.
                 510 East 73rd Street
                 New York, New York  10021
                 Fax # (212) 249-4513
                 Attn:  Dr. Allan R. Goldberg

                 With a copy to:

                 Fullbright & Jaworski L.L.P.
                 666 Fifth Avenue
                 New York, New York 10103
                 Fax # (212) 752-5958
                 Attn:  Merrill M. Kraines, Esq.

or to such other person or place as Innovir shall designate by notice in the
manner provided in this Section 12.3;

             B.  If to VIMRx:

                 VIMRx Pharmaceuticals Inc.
                 2751 Centerville Road
                 Wilmington, Delaware 19808
                 Fax # (302) 998-3794
                 Attn:  Mr. Richard L. Dunning

                 With a copy to:

                 Epstein Becker & Green, P.C.
                 250 Park Avenue
                 New York, New York  10177
                 Fax # (212) 661-0989
                 Attn:  Lowell Lifschultz, Esq.

or to such other person as VIMRx shall designate by notice in the manner
provided in this Section 12.3.

     12.4 Assignment. This Agreement shall be binding upon and inure to the
benefit of Innovir and its successors and assigns, and to VIMRx and its
successors and assigns, but neither this Agreement nor any of the rights,
interests and obligations 


                                       24



<PAGE>


hereunder shall be assigned by either of Innovir or VIMRx without the prior
written consent of the other.

     12.5 Third Parties. This Agreement is not intended to and shall not be
construed to give any Person other than the parties hereto any interest or
rights (including, without limitation, any third party beneficiary rights) with
respect to or in connection with any agreement or provision contained herein or
contemplated hereby.

     12.6 Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of New York, without regard to principles
of conflicts of laws.

     12.7 Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which taken
together shall constitute one and the same instrument.

     12.8 Headings. The headings of the sections, schedules and articles of this
Agreement are inserted for the sake of convenience only and shall not constitute
a part hereof.

     12.9 Entire Agreement. This Agreement, including the schedules and
exhibits, contains the entire understanding of the parties in respect of the
subject matter contained herein and therein and there are no other terms or
conditions, representations or warranties, written or oral, express or implied,
except as set forth herein.

     IN WITNESS WHEREOF, the parties have caused this Agreement to be duly
executed as of the day and year first above written.



                                        INNOVIR LABORATORIES, INC.


                                        By: /s/ ALLAN R. GOLDBERG
                                            -----------------------------------
                                            Dr. Allan R. Goldberg,
                                              Chief Executive Officer




                                        VIMRx PHARMACEUTICALS INC.


                                        By: /s/ RICHARD L. DUNNING
                                            -----------------------------------
                                            Richard L. Dunning, President


                                       25



                              AGREEMENT AND WAIVER

     AGREEMENT AND WAIVER ("Agreement") made this 23rd day of December, 1996 by
and among VIMRx Pharmaceuticals Inc., a Delaware corporation ("VIMRx"), Innovir
Laboratories, Inc., a Delaware corporation ("Innovir"), The Aries Fund, A Cayman
Island Trust ("Aries I"), and The Aries Domestic Fund, L.P. , a Delaware limited
partnership ("Aries II" and, together with Aries I, "The Aries Funds").

                                 R E C I T A L S

     WHEREAS, The Aries Funds and Innovir entered into that certain Stock and
Warrant Purchase Agreement dated as of August 30, 1996 (the "Aries/Innovir
Agreement") pursuant to which The Aries Funds collectively purchased from
Innovir 4,000,000 shares of the common stock, par value $.013 per share ("Common
Stock"), of Innovir, Class C Warrants to purchase an additional 4,000,000 shares
of Innovir's Common Stock, and options ("Unit Purchase Options") to purchase
2,000,000 units, each unit consisting of one share of Innovir Common Stock and
one Class C Warrant to purchase one share of Innovir's Common Stock ("Purchase
Option Warrant"); and

     WHEREAS, The Aries Funds have acquired an additional 6,000,000 shares of
Innovir's Common Stock through the exercise in whole or in part of the Class C
Warrants and the Unit Purchase Options; and

     WHEREAS, on the terms and conditions set forth in that certain Agreement
dated November 21, 1996 by and among VIMRx and the Aries Funds (the "Aries/VIMRx
Agreement"), VIMRx, concurrently herewith is acquiring 9,500,000 of the
10,000,000 shares of Innovir's Common Stock owned by The Aries Funds; and

     WHEREAS, in consideration of, and as a condition to, the consummation of
the transactions contemplated by the Aries/VIMRx Agreement. The Aries Funds
agree to waive compliance by Innovir with certain covenants set forth in the
Aries/Innovir Agreement and Innovir agrees to perform certain covenants, all as
hereinafter set forth;

     NOW, THEREFORE, VIMRx, Innovir and The Aries Funds hereby agree as follows:

     1. Waiver. (a) The Aries Funds hereby irrevocably waive compliance by
Innovir with the following provisions of the Aries/Innovir Agreement:

          i)    Section 5.18 (a);

          ii)   Sections 7.1 and 7.2;

<PAGE>


          iii)  the second sentence of Section 7.4;

          iv)   Sections 7.5 through 7.11 inclusive

          v)    Sections 7.13 through 7.15 inclusive

          vi)   Section 7.17

          vii)  Sections 7.19 through 7.22 inclusive

          viii) Section 7.23(c);

          ix)   Sections 7.24. through 7.26; and

          x)    the last sentence of Section 11.4.

     (b) The Aries Funds hereby waive compliance by Innovir with the provisions
of Section 11.2 of the Aries/Innovir Agreement to the extent, and only to the
extent, such provisions relate to the preparation, negotiation, execution and
delivery of this Agreement.

     2. Amendments to the Aries/Innovir Agreement. Effective the date hereof,
the Aries/Innovir Agreement is hereby amended as follows:

     (a) Section 7.3 is hereby amended to read in full as follows:

         "7.3 Certificates of Compliance. The Company covenants that promptly
         after the occurrence of any default hereunder, it will deliver to
         Purchasers an Officer's Certificate specifying in reasonable detail the
         nature and period of existence thereof, and what actions the Company
         has taken and proposes to take with respect thereto."

     (b) Section 7.12 is hereby amended to read in full as follows:

         "7.12 Amendment of the Certificate of Incorporation and By-Laws.
         Innovir will not amend its Certificate of Incorporation or By-Laws so
         as to adversely affect the rights of Purchasers under this Agreement,
         the Warrants, the Purchase Option Warrants or the Purchase Option."

     3. Acknowledgement. The Aries Funds acknowledge that contemporaneously with
the closing of the Aries/VIMRx Agreement, Innovir will issue to VIMRx 8,666,666
shares of its Class B Convertible Preferred Stock, together with warrants to
purchase 1,000,000 shares of Common Stock of Innovir at $1.00 per share and
warrants to purchase 1,000,000 shares of Common Stock of Innovir at $2.00 per
share, in consideration of the assignment to Innovir of all the issued and
outstanding shares of VIMRx Holdings, Ltd., a Delaware corporation, all as
contemplated by that certain Agreement dated November 21, 1996 by and between
VIMRx and Innovir (the "VIMRx/Innovir Agreement"). The Aries Funds agree that
notwithstanding any provision of the Class C Warrants, the Unit Purchase Options
or the Purchase Option Warrants,

                                        2


<PAGE>


and without prejudice to their rights to adjustment resulting from any future
transactions, no adjustment shall be made to the Purchase Price (as defined in
the Unit Purchase Options), the Per Share Exercise Price (as defined in the 
Class C Warrants) or the number and/or kind of securities purchasable on
exercise of the Unit Purchase Options and/or the Class C Warrants by reason of
the consummation of the transactions contemplated by the VIMRx/Innovir
Agreement.

     4. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of New York, without regard to principles
of conflicts of laws.

     5. Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which taken
together shall constitute one and the same instrument.

     6. Headings. The headings of the paragraphs of this Agreement are inserted
for the sake of convenience only and shall not constitute a part hereof.

     IN WITNESS WHEREOF, the parties have caused this Agreement to be duly
executed as of the day and year first above written.

                                      THE ARIES FUND, A CAYMAN ISLAND TRUST

                                      By:  its Investment Manager,

                                                PARAMOUNT CAPITAL ASSET
                                                MANAGEMENT, INC.

                                      By:  /s/ LINDSAY A. ROSENWALD
                                          -------------------------------------
                                               Lindsay A. Rosenwald, M.D.,
                                               President

                                      THE ARIES DOMESTIC FUND, L.P.

                                      By:  its General Partner,

                                                PARAMOUNT CAPITAL ASSET
                                                MANAGEMENT, INC.

                                      By:  /s/ LINDSAY A. ROSENWALD
                                          -------------------------------------
                                               Lindsay A. Rosenwald, M.D.,
                                               President


                                        3


<PAGE>




                                      VIMRx PHARMACEUTICALS INC.

                                      By:  /s/ FRANCIS M. O'CONNELL
                                           ------------------------------------
                                               Francis M. O'Connell
                                               Chief Financial Officer

                                      INNOVIR LABORATORIES, INC.

                                      By:  /s/ ALLAN R. GOLDBERG
                                           ------------------------------------
                                               Allan R. Goldberg,
                                               President


                                        4



                               SERVICES AGREEMENT

     SERVICES AGREEMENT (this "Agreement") dated December 23, 1996 by and
between VIMRx Pharmaceuticals Inc., a Delaware corporation with offices at 2751
Centerville Road, Wilmington, Delaware 19808 ("VIMRx"), and Innovir
Laboratories, Inc., a Delaware corporation with offices at 510 East 73rd Street,
New York, New York 10021 ("Innovir").

     WHEREAS, Innovir desires to obtain certain administrative and other
services from VIMRx, and VIMRx desires to provide such services to Innovir, all
on the terms and conditions hereinafter set forth.

     NOW, THEREFORE, Innovir and VIMRx hereby agree as follows:

     1. SERVICES. When, as and if requested by Innovir, VIMRx shall provide to
Innovir, and Innovir shall accept from VIMRx, certain services ("Services"),
including the following:

         (a) General management
         (b) Finance
         (c) Administration
         (d) External/investor affairs
         (e) Business development
         (f) Information technology.

Additional services, such as clinical development and regulatory affairs, shall
be provided as the parties mutually agree.

     The Services may be performed by executive employees of VIMRx who may also
serve on the Board of Directors of Innovir. Executive employees of VIMRx shall
receive no cash stipend or other compensation, including stock options, for
serving on the Board of Directors of Innovir, but shall be reimbursed for
reasonable and necessary out-of-pocket expenses incurred by reason of serving on
the Innovir Board of Directors.

     2. PAYMENT; EXAMINATION OF ACCOUNTING RECORDS. Innovir shall pay VIMRx for
the Services as follows: on the 15th day of each month, VIMRx shall invoice
Innovir, at VIMRx's reasonable cost, as determined in accordance with VIMRx's
normal accounting procedures, for Services provided during the preceding
calendar month, which invoice shall be due and payable within 15 days of receipt
thereof by Innovir. VIMRx's costs shall include all out-of-pocket expenses
incurred by VIMRx in connection with providing the Services and a proportionate
share of the salary and benefits of the VIMRx employees who perform the
Services. On reasonable notice to VIMRx, Innovir may, at its expense, review the
books and records of VIMRx which relate to the provision of Services hereunder;
the parties agree to

<PAGE>


discuss and resolve any discrepancies which may come to their attention as a
result of any such review.

     3. INDEMNITY. (a) Innovir hereby agrees to exonerate, indemnify, defend and
hold VIMRx harmless from and against all claims, demands, actions, causes of
action, suits, losses, charges, liabilities and damages, including without
limitation attorney's fees and expenses, of any kind whatsoever (collectively,
"Damages") paid, incurred or suffered by, or asserted against, VIMRx, its
officers, directors, employees, agents, shareholders, successors and assigns,
and the heirs and personal representatives of the foregoing individuals, arising
out of or related to this Agreement or VIMRx's performance hereunder, other than
by reason of VIMRx's gross negligence or wilful malfeasance.

     (b) VIMRx hereby agrees to exonerate, indemnify, defend and hold Innovir
harmless from and against all Damages paid, incurred or suffered by, or asserted
against, Innovir, its officers, directors, employees, agents, shareholders,
successors and assigns, and the heirs and personal representatives of the
foregoing individuals, arising out of or related to this Agreement or VIMRx's
performance hereunder, to the extent, and only to the extent, such Damages are
the result of VIMRx's gross negligence or wilful malfeasance.

     4. NOTICES. All notices, requests, demands and other communications
required or permitted hereunder shall be in writing and shall be deemed to have
been duly given when delivered by hand, or when mailed by certified or
registered mail (return receipt requested), postage prepaid or when delivered by
fax (evidenced by confirmation of successful transmission), as follows:

     If to Innovir:

           Innovir Laboratories, Inc.
           510 East 73rd Street
           New York, New York  10021
           Fax # (212) 249-4513
           Attn:  Dr. Allan R. Goldberg, President

or to such other person or place as Innovir shall designate by notice in the
manner provided in this Paragraph 4.

     If to VIMRx:

           VIMRx Pharmaceuticals Inc.
           2751 Centerville Road
           Wilmington, Delaware 19808
           Fax # (302) 998-3794
           Attn:  Mr. Richard L. Dunning, President


                                        2


<PAGE>


or to such other person as VIMRx shall designate by notice in the manner
provided in this Paragraph 4.

     5. TERM. Unless earlier terminated pursuant to the provisions of Paragraph
3 above, this Agreement shall continue in full force and effect until December
31, 1999, and thereafter for successive periods of one year unless terminated by
either party by written notice given at least six months prior to the end of any
calendar year from and after 1999.

     6. FURTHER ASSURANCES. Each party agrees to execute and deliver such
documents, including letters of authorization and powers of attorney, and take
such other action as shall be reasonably requested by the other to carry out and
effectuate the purposes of this Agreement.

     7. GOVERNING LAW. This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware without regard to principles
of conflict of laws.

     8. COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which taken
together shall constitute one and the same instrument.

     9. HEADINGS. The headings of the paragraphs of this Agreement are inserted
for the sake of convenience only and shall not constitute a part hereof.

     IN WITNESS WHEREOF, the parties have caused this Agreement to be duly
executed as of the day and year first above written.

                                       VIMRx PHARMACEUTICALS INC.



                                       By: /s/ FRANCIS M. O'CONNELL
                                           ------------------------------------
                                           Francis M. O'Connell
                                           Chief Financial Officer



                                       INNOVIR LABORATORIES, INC.



                                       By: /s/ ALLAN R. GOLDBERG
                                           ------------------------------------
                                           Allan R. Goldberg
                                           Chief Executive Officer



                                        3



                                  NEWS RELEASE

                          VIMRx CLOSES DEAL TO ACQUIRE
                         CONTROLLING INTEREST IN INNOVIR

          Combination Will Aid Development of Complimentary Therapeutic
          Technologies That Inhibit Expression of Disease-Linked Genes

     Wilmington, DE, and New York, NY -- January 2, 1997 -- VIMRx
Pharmaceuticals, Inc. (NASDAQ: VMRX) and Innovir Laboratories, Inc. (NASDAQ
SmallCap: INVR) today announced the finalization of a transaction which gives
VIMRx a controlling interest in Innovir Laboratories and through which Innovir
acquired VIMRx's subsidiary, VIMRx Holding Ltd (VHL).

     Innovir and VHL are developing complementary therapeutic technologies that
seek to inhibit the expression of genetic information encoded in
disease-associates genes, interrupting the process of disease causation. Each
company's technology involves a different class of oligomers (Oligozymes) that
are either catalytically active themselves or have the ability to form
catalytically active complexes with cellular components that can inactivate
specific RNA "messenger" molecules that direct cells to produce illness-causing
protcins. VHL, focuses on RILON(TM) Oligozymes and Innovir on External Guide
Sequence, (EGS) Oligozymes. Both technologies, as well as the associates
scientific staffs, have been combined as part of Innovir.

     The final transaction included terms that were modified somewhat from the
original deal. In the final transaction, VIMRx acquired 9.5 million Innovir
shares owned by The Aries Funds for 3 million VIMRx shares and $3 million in
cash. Previously, it was anticipated that consideration for these Innovir shares
would be entirely VIMRx stock, valued at its average trading price between
November 15, 1996 and January 15, 1997, but not to exceed $4.50 per share.

     Richard Dunning, President and Chief Executive Officer of VIMRx, said "We
worked with the Aries Funds to modify the terms because, with VIMRx stock
trading downward for most of the past several weeks, we felt the dilutive impact
of the transaction on VIMRx shareholders would be too great so we substituted
cash for part of the VIMRx stock that otherwise would have been issued. With the
completion of this acquisition, we can move forward aggressively to integrate
the two companies and their complementary technologies. We are extremely pleased
with the progress we have made already, and as Dr. Goldberg's recent talk at the
Sixth Anti-Sense Conference in Japan regarding advances in Innovir's potential
effectiveness in fighting hepatitis B demonstrates, we believe there's still
more to come."

     Pursuant to an amended acquisition agreement, the following events have
taken place:

<PAGE>

*  The Aries Funds, which owned 4 million shares of Innovir stock,
   exercised warrants and options to purchase an additional 6 million
   shares, and thereby provided $3 million in cash to Innovir.

*  VIMRx purchased 9.5 million shares of Innovir stock from The Aries
   Funds for 3 million VIMRx shares and $3 million in cash; and

*  VIMRx exchanged its 100% ownership of its RILON(TM) oligonucleotide
   technology subsidiary -- VHL, valued at $13 million (including cash of
   $4 million) -- for approximately 8.7 million shares of Innovir stock
   valued at $1.50 a share, plus five-year warrants to purchase an
   additional two million shares of Innovir stock (one million at an
   exercise price of $1.00 per share and one million at $2.00 per share).

     As a result of these transactions, VIMRx now owns approximately 68% of
Innovir; the RILON(TM) and EGS technologies are strategically and operationally
combined under the Innovir name; and Innovir has received $7 million in cash,
plus commitments from VIMRx and The Aries Funds to provide an additional $2
million when required through the exercise of warrants.

     In addition, VIMRx has nominated a majority of the Innovir board of
directors. Four directors have already been elected: Mr. Dunning, Dr. David A.
Jackson, VIMRx Chief Scientific Officer, Mr. Francis O'Connell, VIMRx's Chief
Financial Officer, and Laurence D. Fink, Chairman and CEO of Black Rock
Financial Management -- who is also a VIMRx director. Dr. Jackson will also join
the Innovir Science Advisory Board.

     "We are pleased at this major step forward for Innovir," said Dr. Allan R.
Goldberg, Chairman and Chief Executive Officer of Innovir. "There are true
opportunities for synergy here, and we have already begun to take advantage of
them. This is clearly a case of the whole being more than the sum of the parts."

     VIMRx, based in Wilmington, DE, is currently developing two technology
platforms: chemically synthesized hypericin, VIMRxn(R), and, through its
ownership position in Innovir Laboratories, Inc., both EGS and RILON(TM)
Oligozymes, VIMRxyn(R) is currently in clinical development for the treatment of
HIV and brain cancer and is in pre-clinical development for the treatment of
hepatitis C and the sterilization of blood. The Oligozyme technology being
developed by VHL through Innovir has potential uses both in attacking diseases
at the genetic level and as a broadly-applicable tool in pharmaceutical research
to aid in drug target identification and validation. VIMRx also intends to be
active in identifying and acquiring additional technologies and products.

     Innovir Laboratories, Inc. is a biotechnology company that has been
developing External Guide Sequences (EGS), which the Company believes will be a
broad enabling technology. EGS technology is based upon the Nobel Prize-winning
research by Sidney Altman, Ph.D., Sterling Professor of Biology at Yale
University. The Company has an

                                       -2-

<PAGE>


exclusive license to develop this patented technology for new therapeutic
applications and also has independently developed EGS technology not subject to
the Yale license. In addition to hepatitis B, Innovir's initial disease target
areas include psoriasis, inflammation, and drug-resistant microorganisms. The
Company also is developing therapeutic technology that inhibits expression of
disease-linked genes through VHL and is investigating multiple applications for
this technology, including agricultural uses.

     NOTE TO INVESTORS AND EDITORS: VIMRx's press releases are available on the
Internet through Business Wire's web site at

      http://www.businesswire.com/cnn/vmrx.htm.

     The releases also are available at no charge through Business Wire's
fax-on-demand service at 800-411-8792.

                                     * * *

CONTACTS:         WALTER MONTGOMERY OR MARY ANN DUNNELL         FRAN DANIELS
                  (212) 484-6721                                (310) 278-4413

This news release contains forward looking statements which involve risks and
uncertainties. Such statements are subject to certain risk factors which may
cause VIMRx's and/or Innovir's plans to differ. Factors that may cause such
differences include, but are not limited to, the progress and success of each
company's research and development programs, each company's ability to: obtain
additional funds; secure regulatory approval to market its products; compete
successfully; successfully enter into collaborations with third parties; enter
into and progress in clinical trials; establish collaborations with third
parties; enter into and progress in clinical trials; establish development and
commercialization relationships, and manufacture product in a cost-effective
manner. Additional risk factors are discussed under the heading "Risk Factors"
included in Innovir's Form S-3 Registration Statement (Reg. No. 333-12865).


                                       -3-


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