SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
________________________
SCHEDULE 13G
Information Statement pursuant to Rules 13d-1 and 13d-2
Under the Securities Exchange Act of 1934
(Amendment No. )
Trimeris, Inc.
_________________________________________________________________
(Name of Issuer)
Common Stock, $.001 par value
_________________________________________________________________
(Title of Class of Securities)
896263100
_________________________________________________________________
(CUSIP Number)
________________________
<PAGE>
CUSIP No. 896263100 Page 2 of 6 Pages
_________________________________________________________________
1) Name of Reporting Person Biotechnology
S.S. or I.R.S. Identification Investments
No. of Above Person Limited
_________________________________________________________________
2) Check the Appropriate Box (a) [ ]
if a Member of a Group (b) [ ]
_________________________________________________________________
3) SEC Use Only
_________________________________________________________________
4) Citizenship or Place Guernsey,
of Organization Channel Islands
_________________________________________________________________
Number of 5) Sole Voting 1,295,068 shares of
Shares Beneficially Power Common Stock, $.001
Owned by Each par value ("Common
Reporting Person Stock")
________________________________________
6) Shared Voting
Power -0-
________________________________________
7) Sole Disposi- 1,295,068 shares of
tive Power Common Stock
________________________________________
8) Shared Dis-
positive Power -0-
________________________________________
9) Aggregate Amount Beneficially 1,295,068 shares of
Owned by Each Reporting Person Common Stock
_________________________________________________________________
10) Check if the Aggregate
Amount in Row (9)
Excludes Certain Shares
_________________________________________________________________
11) Percent of Class
Represented by 12.3%
Amount in Row (9)
_________________________________________________________________
12) Type of Reporting
Person CO
<PAGE>
CUSIP No. 896263100 Page 3 of 6 Pages
Schedule_13G
____________
Item 1(a) - Name of Issuer: Trimeris, Inc.
Item 1(b) - Address of Issuer's Principal Executive Offices:
4727 University Drive, Suite 100
Durham, NC 27707
Item 2(a) - Name of Person Filing:
This statement is being filed on behalf of
Biotechnology Investments Limited ("BIL" or the
"Reporting Person"). BIL is a Guernsey, Channel
Islands corporation.
Item 2(b) - Address of Principal Business Office:
P.O. Box 58
St. Julian's Court
St. Peter Port
Guernsey, Channel Islands GYI 3BP
Item 2(c) - Place of Organization:
Guernsey, Channel Islands
Item 2(d) - Title of Class of Securities:
Common Stock, $.001 par value ("Common Stock")
Item 2(e) - CUSIP Number: 896263100
Item 3 - Statements Filed Pursuant to Rules 13d-1(b) or
13d-2(b):
Not applicable.
Item 4 - Ownership.
(a) Amount Beneficially Owned:
1,295,068 shares of Common Stock
(b) Percent of Class:
12.3%
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CUSIP No. 896263100 Page 4 of 6 Pages
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the
vote: 1,295,068 shares
(ii) shared power to vote or to direct the
vote: -0-
(iii) sole power to dispose or to direct the
disposition of: 1,295,068 shares
(iv) shared power to dispose or to direct the
disposition of: -0-
Item 5 - Ownership of Five Percent or Less of a Class:
Not applicable.
Item 6 - Ownership of More than Five Percent on Behalf of
Another Person:
Not applicable.
Item 7 - Identification and Classification of the
Subsidiary Which Acquired the Security Being
Reported on By the Parent Company:
Not applicable.
Item 8 - Identification and Classification of Members of
the Group:
Not applicable.
Item 9 - Notice of Dissolution of Group:
Not applicable.
Item 10 - Certification:
Not applicable.
<PAGE>
CUSIP No. 896263100 Page 5 of 6 Pages
Signature:
After reasonable inquiry and to the best of my
knowledge and belief, I certify that the information set forth in
this statement is true, complete and correct.
BIOTECHNOLOGY INVESTMENTS LIMITED
By: Old Court Limited
By /s/ Kathleen K. Schoemaker
Attorney-in-Fact
Date: February 2, 1998
<PAGE>
CUSIP No. 896263100 Page 6 of 6 Pages
OLD COURT LIMITED
P.O. Box 58, St. Julian's Court, St. Peter Port,
Guernsey, Channel Islands GYI 3BP
Our Ref: PF/domain/POA225
_28__January_1998_
Domain Associates
One Palmer Square
Princeton, New Jersey 08542
USA
Dear Sirs
BIOTECHNOLOGY INVESTMENTS LIMITED
We, Old Court Limited hereby authorise you to execute on behalf
of Old Court Limited a Schedule 13G to be filed with the Securi-
ties and Exchange Commission regarding Biotechnology Investments
Limited's holdings of Trimeris, Inc.
Yours very truly
per pro Old Court Limited
/s/ J.J. Nicolle /s/ S.E. Shaw
J.J. Nicolle, Director S.E. Shaw, Director
We confirm that we have authorised Old Court Limited to grant the
above Power of Attorney.
Yours very truly
per pro Biotechnology Investments Limited
/s/ P.A.S. Firth
P.A.S. Firth, Authorised Signatory
