HUMAN GENOME SCIENCES INC
424B3, 2000-04-17
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1

PROSPECTUS SUPPLEMENT NO. 2                  Filed Pursuant to Rule 424(b)(3)
(to Prospectus dated April 3, 2000)          Registration No. 333-33252

                           HUMAN GENOME SCIENCES, INC.

                             --------------------
                                 $225,000,000
                  5% Convertible Subordinated Notes Due 2007
                                       and
                        2,000,000 Shares of Common Stock
                      Issuable Upon Conversion of the Notes
                             --------------------


            The following information supplements information contained in our
      prospectus dated April 3, 2000, relating to the potential offer and sale
      from time to time by holders of the notes and the underlying shares of our
      common stock. See "Plan of Distribution" in our prospectus.

            This prospectus supplement may only be delivered or used in
      connection with our prospectus. This prospectus supplement is incorporated
      by reference into our prospectus. Our common stock is listed on The Nasdaq
      National Market under the symbol "HGSI."

            NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR
      DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS
      SUPPLEMENT OR THE PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION
      TO THE CONTRARY IS A CRIMINAL OFFENSE.

                  Prospectus Supplement dated April 17, 2000


<PAGE>   2




      The notes were originally issued by us and sold by Credit Suisse First
Boston Corporation, as initial purchaser, in a transaction exempt from the
registration requirements of the Securities Act to persons reasonably
believed by the initial purchaser to be qualified institutional buyers or
other institutional accredited investors.  Selling holders, including their
transferees, pledgees or donees or their successors, may from time to time
offer and sell any or all of the notes and common stock into which the notes
are convertible.

                             --------------------

      The following table supplements the information in our prospectus with
respect to the selling holders and the principal amounts of notes and common
stock they beneficially own that may be offered under our prospectus. The
information is based on information provided by or on behalf of the selling
holders. All information provided in this prospectus supplement is as of April
14, 2000.

      The selling holders may offer all, some or none of the notes or common
stock into which the notes are convertible. Thus, we cannot estimate the amount
of the notes or the common stock that will be held by the selling holders upon
termination of any sales. The column showing ownership after completion of the
offering assumes that the selling holders will sell all of the securities
offered by this prospectus supplement. In addition, the selling holders
identified below may have sold, transferred or otherwise disposed of all or a
portion of their notes since the date on which they provided the information
about their notes in transactions exempt from the registration requirements of
the Securities Act. None of the selling holders has had any material
relationship with us or our affiliates within the past three years. No selling
holder named in the table below beneficially owns one percent or more of our
common stock. Common stock owned prior to the offering and after completion of
the offering includes shares of common stock issuable upon conversion of our
5 1/2% Convertible Subordinated Notes Due 2006 and 3 3/4% Convertible
Subordinated Notes Due 2007.

<TABLE>
<CAPTION>
                                       PRINCIPAL
                                       AMOUNT OF                                              COMMON
                                         NOTES           COMMON STOCK                      STOCK OWNED
                                      BENEFICIALLY       OWNED PRIOR          COMMON          AFTER
                                       OWNED AND            TO THE            STOCK       COMPLETION OF
NAME                                    OFFERED            OFFERING          OFFERED       THE OFFERING
- ----                                --------------       -------------    ----------      -------------
<S>                                 <C>                 <C>               <C>             <C>
Bancroft Convertible Fund,
  Inc .......................       $   500,000             4,444             4,444                --
Conseco Fund Group -
  Convertible Securities Fund           500,000             9,010             4,444             4,566
Ellsworth Convertible Growth
  and Income Fund, Inc. .....           500,000             4,444             4,444                --
Forest Global Convertible
  Fund LTD, Series A5 .......        34,840,000           318,820           309,688             9,132
Fortis Bank Luxembourg ......           100,000               888               888                --
KBC Financial Products ......         1,000,000            37,177             8,888            28,289
LLT Limited .................         3,700,000            32,888            32,888                --
                                    -----------       -----------       -----------       -----------

  Total .....................       $41,140,000           407,671           365,684            41,987
                                    ===========       ===========       ===========       ===========
</TABLE>

      Information concerning the selling holders may change from time to time
and any changed information will be set forth in future prospectus supplements
if and when necessary. Further, the per share conversion price, and therefore
the number of shares of common stock issuable upon conversion of the notes, is
subject to adjustment. As a result, the number of shares of common stock into
which the notes are convertible may increase or decrease.



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