<PAGE> 1
Prospectus Supplement No. 1 Filed Pursuant to Rule 424(b)(3)
(to Prospectus dated October 24, 2000) Registration No. 333-47292
1,590,824 Shares
HUMAN GENOME SCIENCES, INC.
Common Stock
----------------
The following information supplements information contained
in our prospectus dated October 24, 2000, relating to the potential
offer and sale from time to time by holders of shares of our common
stock. See "Plan of Distribution" in our prospectus.
This prospectus supplement may only be delivered or used in
connection with our prospectus. This prospectus supplement is
incorporated by reference into our prospectus. Our common stock is
listed on The Nasdaq National Market under the symbol "HGSI."
NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION HAS
APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE
CONTRARY IS A CRIMINAL OFFENSE.
The date of this prospectus supplement is November 7, 2000
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We issued the shares of common stock offered by this prospectus to
the selling stockholders in connection with our acquisition of the outstanding
securities of Principia Pharmaceutical Corporation in a transaction exempt from
the registration requirements of the Securities Act. The selling stockholders,
including their transferees, pledgees or donees or their successors, may from
time to time offer and sell any or all of these shares of common stock. Our
registration of the shares of common stock does not necessarily mean that the
selling stockholders will sell all or any of the shares.
--------------------
The following table supplements the information in our prospectus
with respect to the selling stockholders and the number of shares of common
stock they beneficially own that may be offered under our prospectus. The
information is based on information provided by or on behalf of the selling
stockholders. All information provided in this prospectus supplement is as of
November 6, 2000. Health Care Ventures V, L.P. received 969,938 of our common
stock in connection with our acquisition of the outstanding securities of
Principia Pharmaceutical Corporation and subsequently distributed 921,442 of
those shares to its partners. Information regarding those stockholders is set
forth below.
Because the selling stockholders may sell all or some portion of the
shares of common stock beneficially owned by them, we cannot estimate the number
of shares of common stock that will be beneficially owned by the selling
stockholders after this offering. In addition, the selling stockholders may have
sold, transferred or otherwise disposed of, or may sell, transfer or otherwise
dispose of, at any time or from time to time since the date on which they
provided the information, all or a portion of the shares of common stock
beneficially owned by them in transactions exempt from the registration
requirements of the Securities Act of 1933.
<TABLE>
<CAPTION>
PERCENTAGE OF PERCENTAGE OF
OUTSTANDING SHARES OF OUTSTANDING SHARES
COMMON STOCK OWNED PRIOR COMMON STOCK PRIOR TO COMMON STOCK OF COMMON STOCK
NAME TO THE OFFERING THE OFFERING OFFERED AFTER THE OFFERING
---- --------------- ------------ ------- ------------------
<S> <C> <C> <C> <C>
Larry Abrams ................................. 102,523 * 2,523 *
Lee Casty .................................... 23,471 * 2,523 *
Casty Children's Trust ....................... 24,768 * 7,568 *
Ronald G. Casty .............................. 9,261 * 1,261 *
Cavanaugh Grandchildren's Trust .............. 1,858 * 1,858 *
Elizabeth Cavanaugh-Kerr ..................... 15,433 * 6,969 *
James H. Cavanaugh ........................... 320,268 * 20,852 *
Michael P. Cavanaugh ......................... 15,433 * 6,969 *
Chiao Tung Bank .............................. 10,091 * 10,091 *
Donald S. Crouse ............................. 2,942 * 2,942 *
Geoffrey S. Crouse ........................... 2,942 * 2,942 *
W. Douglas Crouse ............................ 2,942 * 2,942 *
William W. Crouse ............................ 203,691 * 27,821 *
Meredith A. Curran ........................... 252 * 252 *
</TABLE>
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<TABLE>
<CAPTION>
PERCENTAGE OF PERCENTAGE OF
COMMON STOCK OUTSTANDING SHARES OF OUTSTANDING SHARES
OWNED PRIOR COMMON STOCK PRIOR TO COMMON STOCK OF COMMON STOCK
NAME TO THE OFFERING THE OFFERING OFFERED AFTER THE OFFERING
---- --------------- ------------ ------- ------------------
<S> <C> <C> <C> <C>
Sean B. Curran .................................. 252 * 252 *
Ecker N.V. ...................................... 1,009 * 1,009 *
Elan International Services Ltd. ................ 25,228 * 25,228 *
Orrie Friedman .................................. 5,046 * 5,046 *
Genzyme Corporation ............................. 10,091 * 10,091 *
HCV V Holdings................................... 5,550 * 5,550 *
Hoechst Marion Roussel .......................... 25,228 * 25,228 *
Hudson International Holdings Corp............... 61,200 * 25,228 *
Investor Investments Aktiebolag ................. 75,684 * 75,684 *
J.H. Pew Freedom Trust .......................... 496,985 * 3,532 *
J.N. Pew, Jr. Trust ............................. 248,485 * 1,766 *
James D. Isbister Trust ......................... 504 * 504 *
John P. Curran IRA .............................. 504 * 504 *
Laura Jane Littlechild Revocable Trust .......... 5,575 * 5,575 *
Augustine Lawlor ................................ 1,264 * 1,264 *
Mark Leschly .................................... 11,422 * 5,434 *
John W. Littlechild ............................. 75,498 * 25,498 *
M&G Equities .................................... 5,046 * 5,046 *
Mabel Pew Myrin Trust ........................... 319,497 * 2,271 *
Christopher K. Mirabelli ........................ 2,526 * 2,526 *
New Mexico State Investment Council ............. 20,181 * 20,181 *
Novartis Holding AG ............................. 75,684 * 75,684 *
Elliot M. Olstein ............................... 505 * 504 *
Pennsylvania State Employees Retirement System .. 126,138 * 126,138 *
Pew Memorial Trust .............................. 2,484,924 4.5% 17,660 4.5%
Pharmacia & Upjohn .............................. 10,091 * 10,091 *
Rho Management Trust II ......................... 200,936 * 75,684 *
Sarah Grace Littlechild Trust ................... 5,574 * 5,574 *
SmithKline Beecham Corporation .................. 50,456 * 50,456 *
State Farm Mutual Automobile Insurance Co. ...... 50,456 * 50,456 *
State Treasurer of the State of Michigan ........ 100,912 * 100,912 *
Jeffrey Steinberg ............................... 87,181 * 4,181 *
Robert C. Steinberg ............................. 52,289 * 2,789 *
Richard J. Testa ................................ 252 * 252 *
The Wellcome Trust .............................. 37,842 * 37,842 *
Waterville Partners, LP ......................... 5,046 * 5,046 *
Harold Werner ................................... 17,729 * 13,243 *
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Total ........................................ 921,442
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</TABLE>
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*Represents less than 1%.
Information concerning the selling stockholders may change from time
to time and any changed information will be set forth in future prospectus
supplements if and when necessary.
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