HUMAN GENOME SCIENCES INC
424B3, 2000-06-07
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1

PROSPECTUS SUPPLEMENT NO. 8                     Filed Pursuant to Rule 424(b)(3)
(to Prospectus dated February 18, 2000)         Registration No. 333-96387

                           HUMAN GENOME SCIENCES, INC.

                              --------------------

                                  $200,000,000
                   5% Convertible Subordinated Notes Due 2006
                                       and
                        2,792,321 Shares of Common Stock
                      Issuable Upon Conversion of the Notes

                              --------------------


              The following information supplements information contained in our
       prospectus dated February 18, 2000 relating to the potential offer and
       sale from time to time by holders of shares of our common stock issued
       upon conversion of the notes. See "Plan of Distribution" in our
       prospectus.

              This prospectus supplement may only be delivered or used in
       connection with our prospectus. This prospectus supplement is
       incorporated by reference into our prospectus. Our common stock is listed
       on The Nasdaq National Market under the symbol "HGSI."

              NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION HAS APPROVED
       OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS
       SUPPLEMENT OR THE PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION
       TO THE CONTRARY IS A CRIMINAL OFFENSE.

                    Prospectus Supplement dated June 7, 2000


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              The notes were originally issued by us and sold by Credit Suisse
       First Boston Corporation, as initial purchaser, in a transaction exempt
       from the registration requirements of the Securities Act to persons
       reasonably believed by the initial purchaser to be qualified
       institutional buyers or other institutional accredited investors. All of
       the notes have been converted into shares of our common stock. Selling
       holders, including their transferees, pledgees or donees or their
       successors, may from time to time offer and sell any or all of the common
       stock into which the notes were converted.

                              --------------------

              The following table supplements the information in our prospectus
       with respect to the selling holders and the principal amounts of notes
       and common stock they beneficially own that may be offered under our
       prospectus. The information is based on information provided by or on
       behalf of the selling holders. All information provided in this
       prospectus supplement is as of June 6, 2000.

              The selling holders may offer all, some or none of the common
       stock into which the notes were converted. Thus, we cannot estimate the
       amount of the common stock that will be held by the selling holders upon
       termination of any sales. The column showing ownership after completion
       of the offering assumes that the selling holders will sell all of the
       securities offered by this prospectus supplement. In addition, the
       selling holders identified below may have sold, transferred or otherwise
       disposed of all or a portion of their common stock since the date on
       which they provided the information about their common stock in
       transactions exempt from the registration requirements of the Securities
       Act. None of the selling holders has had any material relationship with
       us or our affiliates within the past three years. No selling holder named
       in the table below beneficially owns one percent or more of our common
       stock. Common stock owned prior to the offering and after completion of
       the offering includes shares of common stock issuable upon conversion of
       our 5 1/2% Convertible Subordinated Notes Due 2006, our 5% Convertible
       Subordinated Notes Due 2007 and our 3 3/4% Convertible Subordinated Notes
       Due 2007. Information concerning the selling holders may change from time
       to time and any changed information will be set forth in future
       prospectus supplements if and when necessary.

<TABLE>
<CAPTION>
                                                                                                COMMON
                                                                                             STOCK OWNED
                                  PRINCIPAL AMOUNT OF      COMMON STOCK        COMMON           AFTER
                                  NOTES   BENEFICIALLY    OWNED PRIOR TO       STOCK        COMPLETION OF
NAME                               OWNED AND OFFERED       THE OFFERING       OFFERED        THE OFFERING
----                               -----------------      -------------       --------       ------------
<S>                               <C>                    <C>                 <C>             <C>
Sage Capital ............             $1,950,000              54,451           27,225           27,226

</TABLE>






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