HUMAN GENOME SCIENCES INC
S-8 POS, 2000-08-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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       As filed with the Securities and Exchange Commission on August 30, 2000
                           Registration No. 33-79022

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                 Post-Effective

                               Amendment No. 1 to

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                           HUMAN GENOME SCIENCES, INC.
             (Exact name of registrant as specified in its charter)

            Delaware                                   22-3178468
  (State or other jurisdiction of          (I.R.S. Employer Identification No.)
   Incorporation or organization)

        9410 Key West Avenue
         Rockville, Maryland                          20850-3338
  (Address of principal executive offices)            (Zip Code)


                 HUMAN GENOME SCIENCES, INC. 1993 Incentive and
                         Non-qualified Stock Option Plan
                              (Full title of plan)

                          (Name, address and telephone
                          number of agent for service)
                           William A. Haseltine, Ph.D.
                           Human Genome Sciences, Inc.
                              9410 Key West Avenue
                         Rockville, Maryland 20850-3338
                                 (301) 309-8504


                                   (Copy to:)
                            R.W. Smith, Jr., Esquire
                        Piper Marbury Rudnick & Wolfe LLP
                                6225 Smith Avenue
                         Baltimore, Maryland 21209-3600
                                 (410) 580-3000

                           ---------------------------


<PAGE>


                                EXPLANATORY NOTE

         Human Genome Sciences, Inc., a Delaware corporation (the "Registrant"),
filed a Registration  Statement on Form S-8 on May 17, 1994 (file no.  33-79022)
to register shares of the  Registrant's  Common Stock, par value $0.01 par value
(the "Common  Stock"),  for offer or sale pursuant to the Human Genome Sciences,
Inc. 1993 Incentive and Non-qualified  Stock Option Plan (the "1993 Plan").  The
Registrant  adopted a new stock incentive plan, the Human Genome Sciences,  Inc.
2000 Stock  Incentive Plan (the "2000 Plan"),  and merged the 1993 Plan into the
2000 Plan, on February 16, 2000.

         Shares that were  available  for grant under the 1993 Plan  immediately
prior to the merger of the plans became  available  for issuance  under the 2000
Plan pursuant to the merger.  In addition,  if the  outstanding  awards  granted
under the 1993 Plan expire or are forfeited,  cancelled or otherwise terminated,
or if any  shares  of Common  Stock  are  surrendered,  or are  withheld  by the
Registrant,  in connection  with any  outstanding  awards granted under the 1993
Plan, the shares subject to such awards and the  surrendered or withheld  shares
will be available for issuance  under the 2000 Plan.  The total number of shares
subject to outstanding  awards granted under the 1993 Plan and shares  available
for grant  under the 1993 Plan  immediately  prior to the merger of the plans is
273,364 shares (the "Carried Forward Shares").

         Contemporaneously with the filing of this Post-Effective  Amendment No.
1 to the Registration Statement on Form S-8 (file no. 33-79022),  the Registrant
is filing a  Registration  Statement  on Form S-8 to  register  shares of Common
Stock for offer or sale pursuant to the 2000 Plan,  including but not limited to
the Carried Forward Shares.  Accordingly,  in accordance with the principles set
forth in Interpretation  89 under Section G of the Manual of Publicly  Available
Telephone  Interpretations  of  the  Division  of  Corporation  Finance  of  the
Securities and Exchange  Commission (July 1997) and Instruction E to the General
Instructions  to Form S-8, this  Post-Effective  Amendment No. 1 is hereby filed
(i) to  reallocate  the  Carried  Forward  Shares from the 1993 Plan to the 2000
Plan, and (ii) to carry over the registration  fees paid for the Carried Forward
Shares from the  Registration  Statement on Form S-8 filed for the 1993 Plan, to
the  Registration  Statement  on Form  S-8  for  the  2000  Plan  that is  filed
contemporaneously with the filing of this Post-Effective Amendment No. 1.



<PAGE>


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly authorized, in the City of Rockville, State of Maryland, on the 30th day of
August, 2000.

                                   HUMAN GENOME SCIENCES, INC.


                                   By:  /s/ William A. Haseltine
                                        -----------------------------------
                                        William A. Haseltine, Ph.D.
                                        Chairman of the Board and
                                        Chief Executive Officer

                               POWERS OF ATTORNEY

         Each person whose  signature  appears  below  constitutes  and appoints
William A. Haseltine,  Ph.D., as his true and lawful attorney-in-fact and agent,
with full power of substitution and  resubstitution,  for such person and in his
name,  place and stead,  in any and all  capacities,  to sign any or all further
amendments (including post-effective amendments) to this Registration Statement,
and to file  the  same,  with all  exhibits  thereto,  and  other  documents  in
connection therewith, with the Securities and Exchange Commission, granting unto
said attorney-in-fact and agent, full power and authority to do and perform each
and every  act and thing  requisite  and  necessary  to be done in and about the
premises,  as  fully  to all  intents  and  purposes  as he might or could do in
person,  hereby  ratifying and  confirming  all that said  attorney-in-fact  and
agent, or his substitute or substitutes,  may lawfully do or cause to be done by
virtue hereof.

         Pursuant to the  requirements  of the Securities Act of 1933, this Form
S-8  Registration  Statement  has been  signed by the  following  persons in the
capacities and on the date indicated.


<TABLE>
<S>                                        <C>                                                     <C>
Signature                                                     Title                                        Date

/s/ William A. Haseltine                   Chairman of the Board of Directors and Chief              August 30, 2000
---------------------------------                       Executive Officer
William A. Haseltine, Ph.D.                       (principal executive officer)


/s/ Steven C. Mayer                                 Senior Vice President and                        August 30, 2000
---------------------------------                    Chief Financial Officer
Steven C. Mayer                            (principal financial and accounting officer)


/s/ Craig A. Rosen                           Executive Vice President - Research and                 August 30, 2000
---------------------------------                    Development and Director
Craig A. Rosen, Ph.D.


/s/ Laura D'Andrea Tyson                                     Director                                August 30, 2000
---------------------------------
Laura D'Andrea Tyson, Ph.D.


/s/ Max Link                                                 Director                                August 30, 2000
---------------------------------
Max Link, Ph.D.


/s/ Robert D. Hormats                                        Director                                August 30, 2000
---------------------------------
Robert D. Hormats

/s/James B. Wyngaarden                                       Director                                August 30, 2000
---------------------------------
James B. Wyngaarden, M.D.
</TABLE>




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