NORWEST EQUITY PARTNERS IV/ITASCA PARTNERS/ZICARELLI ROBERT
SC 13G/A, 1997-10-15
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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No. 2)

GelTex Pharmaceuticals, Inc.
(Name of Issuer)

Common Stock
(Title of Class of Securities)

368538 10 4
(CUSIP Number)



Check the following box if a fee is being paid with this statement [ ].  
(A fee is not required only if the filing person:  (1) has a previous 
statement on file reporting beneficial ownership of more than five 
percent of the class of securities described in Item 1; and (2) has 
filed no amendment subsequent thereto reporting beneficial ownership of 
five percent or less of such class.)  (See Rule 13d-7).

*The remainder of this cover page shall be filled out for a reporting 
person's initial filing on this form with respect to the subject class 
of securities, and for any subsequent amendment containing information 
which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not 
be deemed to be "filed" for the purpose of Section 18 of the Securities 
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of 
that section of the Act but shall be subject to all other provisions of 
the Act (however, see the Notes).



                                   13G

CUSIP NO.  368538 10 4


1)        NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Norwest Equity Partners IV
            Tax Identification No.  41-1647118

2)        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                               (b)  [ ]
3)        SEC USE ONLY

4)        CITIZENSHIP OR PLACE OF ORGANIZATION

            Minnesota

NUMBER OF          (5)  SOLE VOTING POWER
SHARES                    0
BENEFICIALLY       (6)  SHARED VOTING POWER
OWNED BY                  0
EACH               (7)  SOLE DISPOSITIVE POWER
REPORTING                 0
PERSON             (8)  SHARED DISPOSITIVE POWER
WITH                      0

9)         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
             0

10)        CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN 
           SHARES*

11)        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
             Less than 5%

12)        TYPE OF REPORTING PERSON*

             PA







                                   13G

CUSIP NO.  368538 10 4


1)        NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Itasca Partners
            Tax Identification No.  41-1647117

2)        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                               (b)  [ ]
3)        SEC USE ONLY

4)        CITIZENSHIP OR PLACE OF ORGANIZATION

            Minnesota

NUMBER OF          (5)  SOLE VOTING POWER
SHARES                    0
BENEFICIALLY       (6)  SHARED VOTING POWER
OWNED BY                  0
EACH               (7)  SOLE DISPOSITIVE POWER
REPORTING                 0
PERSON             (8)  SHARED DISPOSITIVE POWER
WITH                      0

9)         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
             0

10)        CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN 
           SHARES*

11)        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
             Less than 5%

12)        TYPE OF REPORTING PERSON*

             PA




13G

CUSIP NO.  368538 10 4


1)        NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Robert F. Zicarelli
            Social Security No.  ###-##-####

2)        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                               (b)  [ ]
3)        SEC USE ONLY

4)        CITIZENSHIP OR PLACE OF ORGANIZATION

            United States of America

NUMBER OF          (5)  SOLE VOTING POWER
SHARES                    0
BENEFICIALLY       (6)  SHARED VOTING POWER
OWNED BY                  0
EACH               (7)  SOLE DISPOSITIVE POWER
REPORTING                 0
PERSON             (8)  SHARED DISPOSITIVE POWER
WITH                      0

9)         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
             0

10)        CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN 
           SHARES*

11)        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
             Less than 5%

12)        TYPE OF REPORTING PERSON*

             IN



13G

CUSIP NO.  368538 10 4


1)        NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Daniel J. Haggerty
            Social Security No.  ###-##-####

2)        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                               (b)  [ ]
3)        SEC USE ONLY

4)        CITIZENSHIP OR PLACE OF ORGANIZATION

            United States of America

NUMBER OF          (5)  SOLE VOTING POWER
SHARES                    0
BENEFICIALLY       (6)  SHARED VOTING POWER
OWNED BY                  0
EACH               (7)  SOLE DISPOSITIVE POWER
REPORTING                 0

PERSON             (8)  SHARED DISPOSITIVE POWER
WITH                      0

9)         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
             0


10)        CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN 
           SHARES*

11)        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
             Less than 5%

12)        TYPE OF REPORTING PERSON*

             IN




SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549

SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 2)


Item 1(a)  Name of Issuer:

           GelTex Pharmaceuticals, Inc.

Item 1(b)  Address of Issuer's Principal Executive Offices:

           303 Bear Hill Road
           Waltham, MA  02154
 
Item 2(a)  Name of Person Filing:

           1.  Norwest Equity Partners IV
           2.  Itasca Partners
           3.  Robert F. Zicarelli
           4.  Daniel J. Haggerty

Item 2(b)  Address of Principal Business Office:

           1.  Norwest Equity Partners IV
               2800 Piper Jaffray Tower
               222 South Ninth Street
               Minneapolis, MN  55402

           2.  Itasca Partners
               2800 Piper Jaffray Tower
               222 South Ninth Street
               Minneapolis, MN  55402

           3.  Robert F. Zicarelli
               2800 Piper Jaffray Tower
               222 South Ninth Street
               Minneapolis, MN  55402

           4.  Daniel J. Haggerty
               2800 Piper Jaffray Tower
               222 South Ninth Street
               Minneapolis, MN  55402

           This statement is filed by Norwest Equity Partners IV on
           behalf of all of the persons listed above pursuant to
           Rule 13d-1(c) and Rule 13d-1(f).  Norwest Equity Partners
           IV is a Minnesota limited partnership.  Itasca Partners, 
           a Minnesota general partnership, is the general partner of
           Norwest Equity Partners IV.  Robert F. Zicarelli and
           Daniel J. Haggerty are the managing partners of Itasca
           Partners.

Item 2(c)  Citizenship:

           1.  Norwest Equity Partners IV:  Minnesota
           2.  Itasca Partners:  Minnesota
           3.  Robert F. Zicarelli:  United States
           4.  Daniel J. Haggerty:  United States

Item 2(d)  Title of Class of Securities:

           Common Stock

Item 2(e)  CUSIP Number:

           368538 10 4

Item 3     Not Applicable

Item 4     Ownership:

           (1)  Norwest Equity Partners IV:  At September 30, 1997,
                Norwest Equity Partners IV owned no shares of common
                stock.  This amount represented less than 5% of the
                total shares of common stock outstanding at that date.
                Norwest Equity Partners IV has no rights to acquire
                additional shares through the exercise of options or
                otherwise.

           (2)  Itasca Partners:  At September 30, 1997, Itasca 
                Partners was deemed to own, by virtue of its 
                affiliation with Norwest Equity Partners IV, no shares 
                of common stock.  This amount represented less than 5% 
                of the total shares of common stock outstanding at that 
                date.

           (3)  Robert F. Zicarelli:  At September 30, 1997, Robert F.
                Zicarelli was deemed to own, by virtue of his 
                affiliation with Norwest Equity Partners IV, no 
                shares of common stock.  This amount represented less 
                than 5% of the total shares of common stock outstanding 
                at that date.

           (4)  Daniel J. Haggerty:  At September 30, 1997, Daniel J.
                Haggerty was deemed to own, by virtue of his 
                affiliation with Norwest Equity Partners IV, no 
                shares of common stock.  This amount represented less 
                than 5% of the total shares of common stock outstanding 
                at that date.

                The persons filing this statement other than Norwest 
                Equity Partners IV disclaim beneficial ownership of, 
                and the filing of this shall not be construed as an 
                admission that the persons filing are beneficial 
                owners of, the shares covered by this statement for 
                purposes of Sections 13, 14, or 16 of the Act.

Item 5     Ownership of Five Percent or Less of a Class:

           If this statement is being filed to report the fact that as
           of the date hereof the reporting persons have ceased to be
           beneficial owners of more than five percent of the class of
           securities, check the following [X].



Item 6     Ownership of More than Five Percent on Behalf of Another 
           Person:

           Not Applicable

Item 7     Identification and Classification of the Subsidiary Which 
           Acquired the Security Being Reported on by the Parent
           Holding Company:

           Not Applicable

Item 8     Identification and Classification of Members of the Group:

           Not Applicable

Item 9     Notice of Dissolution of Group:

           Not Applicable

Item 10    Certification:

           By signing below, I certify that, to the best of my
           knowledge and belief, the securities referred to above were
           acquired in the ordinary course of business and were not
           acquired for the purpose of and do not have the effect of
           changing or influencing the control of the issuer of such
           securities and were not acquired in connection with or as a
           participant in any transaction having such purposes or
           effect.

Signature.

After reasonable inquiry and to the best of my knowledge and belief, I 
certify that the information set forth in this statement is true, 
complete, and correct.

Date:  October 14, 1997

NORWEST EQUITY PARTNERS IV

By ITASCA PARTNERS, as general partner



By:  /s/ John P. Whaley
         John P. Whaley, Partner


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