SIGMA ALDRICH CORP
SC 13G/A, 2000-02-03
CHEMICALS & ALLIED PRODUCTS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 15)


                            SIGMA-ALDRICH CORPORATION
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                              Class A Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   826552 10 1
              -----------------------------------------------------
                                 (CUSIP Number)

                                December 31, 1999
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

         [ ]     Rule 13d-1(b)

         [ ]     Rule 13d-1(c)

         [X]     Rule 13d-1(d)


*      The  remainder  of this  cover  page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                        (Continued on following page(s))
                                Page 1 of 3 Pages
<PAGE>

- ----------------------
CUSIP No. 826552 10 1
- ----------------------


================================================================================
   1     NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Alfred R. Bader (###-##-####)

- --------------------------------------------------------------------------------
  2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                                      (a)[ ]
                                                                      (b)[ ]
         N/A
- --------------------------------------------------------------------------------
  3      SEC USE ONLY

- --------------------------------------------------------------------------------
  4      CITIZENSHIP OR PLACE OF ORGANIZATION

         United States
- --------------------------------------------------------------------------------
                    5      SOLE VOTING POWER

   NUMBER OF               5,274,260
                   -------------------------------------------------------------
    SHARES          6      SHARED VOTING POWER

  BENEFICIALLY             -0-

    OWNED BY       -------------------------------------------------------------
                    7      SOLE DISPOSITIVE POWER
     EACH
                           5,274,260
   REPORTING
                   -------------------------------------------------------------
    PERSON         8       SHARED DISPOSITIVE POWER

     WITH                  -0-

- --------------------------------------------------------------------------------
  9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         5,274,260
- --------------------------------------------------------------------------------
 10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES (SEE INSTRUCTIONS)                                       [ ]

         N/A
- --------------------------------------------------------------------------------
 11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         5.23%*
- --------------------------------------------------------------------------------
 12      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

         IN
================================================================================


- ------------------
* Based on an  aggregate of  100,893,818  shares  outstanding  as of October 31,
1999.

                                Page 2 of 3 Pages
<PAGE>

- ----------------------
CUSIP No. 826552 10 1
- ----------------------



          This  amendment  No. 15 to Schedule  13G with regard to  Sigma-Aldrich
Corporation  is being filed on behalf of the  undersigned to amend Item 4 of the
originally  filed Schedule 13G.  Except as expressly  stated herein,  there have
been no material changes in the information set forth in the Schedule 13G.


     Item 4.   Ownership
     ------    ---------

               Keeley Asset Management Corp.
               ----------------------------

               (a)  Amount Beneficially Owned: 5,274,260

               (b)  Percent of Class: 5.23%

               (c)  Number of shares as to which such person has:

                    (i)  sole power to vote or to direct the vote: 5,274,260

                    (ii) shared power to vote or to direct the vote: -0-

                    (iii)sole power to dispose or to direct the  disposition of:
                         5,274,260

                    (iv) shared  power to dispose  or to direct the  disposition
                         of: -0-


                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                   Dated this 1st day of February, 2000.



/s/ Alfred R. Bader
- -----------------------------------
Alfred R. Bader





                                Page 3 of 3 Pages


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