GILDER GAGNON HOWE & CO LLC
SC 13G/A, 1999-08-10
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                ----------------


                    Under the Securities Exchange Act of 1934

                                  SCHEDULE 13G
                                (Amendment No. 1)


             INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                         Premier Research Worldwide Ltd.
                         -------------------------------
                                (Name of Issuer)


                                  Common Stock
                                  ------------
                         (Title of Class of Securities)


                                    740568100
                                    ---------
                                 (CUSIP Number)


                                  July 31, 1999
              ----------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check   the  appropriate  box to  designate  the rule  pursuant  to  which  this
        Schedule is filed:

|X| Rule 13d-1(b)
|_| Rule 13d-1(c)
|_| Rule 13d-1(d)

                                Page 1 of 6 Pages

<PAGE>

                                  SCHEDULE 13G

CUSIP No. 740568100                                            Page 2 of 6 Pages
- --------------------------------------------------------------------------------
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Gilder Gagnon Howe & Co. LLC
        13-3174112
- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP             (a) |_|

                                                                     (b) |_|
- --------------------------------------------------------------------------------
3)      SEC USE ONLY

- --------------------------------------------------------------------------------
4)      CITIZENSHIP OR PLACE OF ORGANIZATION

        New York
- --------------------------------------------------------------------------------
        NUMBER           5)    SOLE VOTING POWER
        OF
        SHARES                15,775
        BENEFICIALLY     -------------------------------------------------------
        OWNED BY         6)    SHARED VOTING POWER
        EACH
        REPORTING              None
        PERSON           -------------------------------------------------------
        WITH             7)    SOLE DISPOSITIVE POWER

                               None
                         -------------------------------------------------------
                         8)    SHARED DISPOSITIVE POWER

                               1,500,565

- --------------------------------------------------------------------------------
9)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            1,500,565
- --------------------------------------------------------------------------------
10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES                                                            |_|
- --------------------------------------------------------------------------------
11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

        21.3%
- --------------------------------------------------------------------------------
12)     TYPE OF REPORTING PERSON

        BD
- --------------------------------------------------------------------------------

                                Page 2 of 6 Pages

<PAGE>

                                  Schedule 13G

Item 1(a). Name of Issuer:

Premier Research Worldwide Ltd.

Item 1(b). Address of Issuer's Principal Executive Offices:

124 South 15th Street
Philadelphia, PA 19102

Item 2(a). Name of Person Filing:

Gilder Gagnon Howe & Co. LLC

Item 2(b). Address of Principal Business Office or, if None, Residence:

1775 Broadway, 26th Floor
New York, NY  10019

Item 2(c). Citizenship:

New York

Item 2(d). Title of Class of Securities:

Common Stock

Item 2(e). CUSIP Number:
740568100

Item  3.   If this  statement  is filed  pursuant to  ss.ss.240.13D-1(B),  or
           240.13D-2(B) or (C), check whether the person filing is a:

           (a) |X| Broker or Dealer  Registered  Under Section 15 of the Act (15
                   U.S.C. 78o)

           (b) |_| Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c)

           (c) |_| Insurance  Company as defined in section  3(a)(19) of the Act
                   (15 U.S.C. 78c)

           (d) |_| Investment   Company   registered  under  section  8  of  the
                   Investment Company Act of 1940 (15 U.S.C. 80a-8)

           (e) |_| Investment       Adviser       in       accordance       with
                   ss.240.13d-1(b)(1)(ii)(E)

                                Page 3 of 6 Pages

<PAGE>

           (f) |_| Employee  benefit plan or endowment  fund in accordance  with
                   ss.240.13d-1(b)(1)(ii)(F)

           (g) |_| Parent Holding  Company or control person in accordance  with
                   ss.240.13d-1(b)(ii)(G)

           (h) |_| Savings  Association  as defined  in  ss.3(b) of the  Federal
                   Deposit Insurance Act (12 U.S.C. 1813)

           (i) |_| Church  plan  that is  excluded  from  the  definition  of an
                   investment   company  under  ss.3(c)(15)  of  the  Investment
                   Company Act of 1940 (15 U.S.C. 80a-3)

           (j) |_|  Group, in accordance with ss.240.13d-1(b)(ii)(J)

Item 4.    Ownership.

           (a)  Amount beneficially owned:  1,500,565

           (b)  Percent of class:   21.3%

           (c) Number of shares as to which such person has:

                  (i)   Sole power to vote or to direct the vote:  15,775

                  (ii)  Shared power to vote or to direct the vote:  None

                  (iii) Sole power to dispose or to direct the  disposition  of:
                        None

                  (iv)  Shared power to dispose or to direct the disposition of:
                        1,500,565

The shares  reported  include  1,251,715  shares held in customer  accounts over
which  members  and/or  employees  of the  Reporting  Person have  discretionary
authority to dispose of or direct the disposition of the shares,  233,075 shares
held in  accounts  owned  by the  members  of the  Reporting  Person  and  their
families,  and 15,775 shares held in the account of the  profit-sharing  plan of
the Reporting  Person ("the  Profit-Sharing  Plan").

Item 5.    Ownership of Five Percent or Less of a Class.

Not applicable.

                                Page 4 of 6 Pages

<PAGE>

Item 6.    Ownership of More than Five Percent on Behalf of Another Person.

           The owners of the accounts  (including  the  Profit-Sharing  Plan) in
which the shares reported on this Schedule are held have the right to receive or
the power to direct the receipt of dividends from, or the proceeds from the sale
of, such securities.

Item 7.    Identification  and  Classification  of the Subsidiary Which Acquired
           the Security Being Reported on by the Parent Holding Company.

Not applicable.

Item 8.    Identification and Classification of Members of the Group.

Not applicable.

Item 9.    Notice of Dissolution of Group.

Not applicable.

Item 10.   Certification.

           By signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities referred to above were acquired in the ordinary course of
business  and were not acquired for the purpose of and do not have the effect of
changing or  influencing  the control of the issuer of such  securities and were
not acquired in connection  with or as a participant in any  transaction  having
such purposes or effect.

                                Page 5 of 6 Pages

<PAGE>

                                    SIGNATURE


           After reasonable  inquiry and to the best knowledge and belief of the
undersigned,  the  undersigned  certifies that the information set forth in this
Statement is true, complete and correct.


                                            August 10, 1999
                                            ---------------
                                                Date


                                            /s/ Walter Weadock
                                            ------------------
                                                Signature


                                            Walter Weadock, Member
                                            ----------------------
                                                Name/Title

                                Page 6 of 6 Pages




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