GOLDMAN SACHS GROUP LP
4, 1998-12-10
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<PAGE>
                                          



                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[   ] Check this box if no longer subject to Section 16. Form 4 or Form 5
      obligations may continue. See Instruction 1(b).
================================================================================
1. Name and Address of Reporting Person*

   The Goldman Sachs Group, L.P.
- --------------------------------------------------------------------------------
   (Last)                           (First)             (Middle)

   85 Broad Street
- --------------------------------------------------------------------------------
                                    (Street)

   New York,                         New York             10004
- --------------------------------------------------------------------------------
   (City)                           (State)              (Zip)


================================================================================
2. Issuer Name and Ticker or Trading Symbol

   Applied Analytical Industries, Inc.
   (AAII)
================================================================================
3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary)


================================================================================
4. Statement for Month/Year

   November/1998
================================================================================
5. If Amendment, Date of Original (Month/Year)


================================================================================
6. Relationship of Reporting Person(s) to Issuer
   (Check all applicable)

   [   ]   Director                             [ X ]   10% Owner
   [   ]   Officer (give title below)           [   ]   Other (specify below)



               -------------------------------------------

================================================================================
7. Individual or Joint/Group Filing (Check Applicable Line)

   [   ] Form filed by One Reporting Person
   [ X ] Form filed by More than One Reporting Person

================================================================================
<PAGE>
<TABLE>
<CAPTION>
====================================================================================================================================
                              Table I -- Non-Derivative Securities Acquired, Disposed of,                                          |
                                                 or Beneficially Owned                                                             |
====================================================================================================================================
                                    |            |            |                                |              |6.       |          |
                                    |            |            | 4.                             |5.            |Owner-   |          |
                                    |            |            | Securities Acquired (A) or     |Amount of     |ship     |          |
                                    |            | 3.         | Disposed of (D)                |Securities    |Form:    |7.        |
                                    |2.          | Transaction| (Instr. 3, 4 and 5)            |Beneficially  |Direct   |Nature of |
                                    |Transaction | Code       | -------------------------------|Owned at End  |(D) or   |Indirect  |
1.                                  |Date        | (Instr. 8) |               | (A) |          |of Month      |Indirect |Beneficial|
Title of Security                   |(Month/Day/ | -----------|     Amount    | or  |  Price   |(Instr. 3     |(I)      |Ownership |
(Instr. 3)                          |Year)       |  Code  | V |               | (D) |          |and 4)        |(Instr.4)|(Instr. 4)|
- -----------------------------------------------------------------------------------------------------------------------------------|
<S>                                 <C>          <C>      <C> <C>             <C>   <C>        <C>            <C>       <C>
                                    |            |        |   |               |     |          |              |         |          |
Common Stock                        | 11/10/98   |  J(01) |   |  114.452632   | A   | $17.125  |   114.452632 |   01    |    01    |
- -----------------------------------------------------------------------------------------------------------------------------------|
                                    |            |        |   |               |     |          |              |         |          |
Common Stock                        |            |        |   |               |     |          |   150        |   02    |    02    |
- -----------------------------------------------------------------------------------------------------------------------------------|
                                    |            |        |   |               |     |          |              |         |          |
Common Stock                        |            |        |   |               |     |          |   2,276,832  |   03    |    03    |
- -----------------------------------------------------------------------------------------------------------------------------------|
                                    |            |        |   |               |     |          |              |         |          |
                                    |            |        |   |               |     |          |              |         |          |
- -----------------------------------------------------------------------------------------------------------------------------------|
                                    |            |        |   |               |     |          |              |         |          |
                                    |            |        |   |               |     |          |              |         |          |
====================================================================================================================================
</TABLE>
Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction
  4(b)(v).

FORM 4 (continued)
<TABLE>
<CAPTION>
====================================================================================================================================
                    Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned                                 |
                            (e.g., puts, calls, warrants, options, convertible securities)                                         |
====================================================================================================================================

               |        |        |      |               |                 |                       |        |9.       |10.   |      |
               |        |        |      |               |                 |                       |        |Number   |Owner-|      |
               |        |        |      |               |                 |                       |        |of       |ship  |      |
               |2.      |        |      |               |                 |                       |        |Deriv-   |of    |      |
               |Conver- |        |      | 5.            |                 |7.                     |        |ative    |Deriv-|11.   |
               |sion    |        |      | Number of     |                 |Title and Amount       |        |Secur-   |ative |Nature|
               |or      |        |      | Derivative    |6.               |of Underlying          |8.      |ities    |Secur-|of    |
               |Exer-   |        |4.    | Securities    |Date             |Securities             |Price   |Bene-    |ity:  |In-   |
               |cise    |3.      |Trans-| Acquired (A)  |Exercisable and  |(Instr. 3 and 4)       |of      |ficially |Direct|direct|
               |Price   |Trans-  |action| or Disposed   |Expiration Date  |-----------------------|Deriv-  |Owned    |(D) or|Bene- |
1.             |of      |action  |Code  | of (D)        |(Month/Day/Year) |             |Amount   |ative   |at End   |In-   |ficial|
Title of       |Deriv-  |Date    |(Instr| (Instr. 3,    |-----------------|             |or       |Secur-  |of       |direct|Owner-|
Derivative     |ative   |(Month/ |8)    | 4 and 5)      |Date    |Expira- |             |Number   |ity     |Month    |(I)   |ship  |
Security       |Secur-  |Day/    |------| ------------  |Exer-   |tion    |             |of       |(Instr. |(Instr.  |(Instr|(Instr|
(Instr. 3)     |ity     |Year)   |Code|V|  (A)  | (D)   |cisable |Date    |Title        |Shares   |5)      |4)       |4)    |4)    |
- -----------------------------------------------------------------------------------------------------------------------------------|
<S>            <C>      <C>      <C>  <C><C>    <C>     <C>      <C>      <C>           <C>       <C>      <C>       <C>    <C>
               |        |        |    | |       |       |        |        |             |         |        |         |      |      |
               |        |        |    | |       |       |        |        |             |         |        |         |      |      |
- -----------------------------------------------------------------------------------------------------------------------------------|
               |        |        |    | |       |       |        |        |             |         |        |         |      |      |
               |        |        |    | |       |       |        |        |             |         |        |         |      |      |
- -----------------------------------------------------------------------------------------------------------------------------------|
               |        |        |    | |       |       |        |        |             |         |        |         |      |      |
               |        |        |    | |       |       |        |        |             |         |        |         |      |      |
====================================================================================================================================
</TABLE>
Instruction 4(b)(v) list of other Reporting Persons:

This  statement  is being filed by GS Capital  Partners  II, L.P.  ("GSCP"),  GS
Capital Partners II Offshore,  L.P.("GSCP II Offshore"),  GS Capital Partners II
(Germany)  C.L.P.  ("GSCP  II  Germany",  and  together  with  GSCP  and GSCP II
Offshore, "GSCPII"), GS Advisors, L.P. ("GS Advisors"), GS Advisors II (Cayman),
L.P. ("GS Advisors Cayman"), Goldman, Sachs & Co. oHG ("GS oHG"), Goldman, Sachs
& Co.  ("Goldman  Sachs") and The Goldman  Sachs  Group,  L.P.  ("GS Group" and,
together with GSCPII, GS Advisors, GS Advisors Cayman, GS oHG and Goldman Sachs,
the  "Reporting  Persons").  The principal  business  address of each of Goldman
Sachs,  GS Group,  GSCP and GS Advisors is 85 Broad Street,  New York,  New York
10004.  The  principal  business  address  for each of GSCP II  Offshore  and GS
Advisors  Cayman is c/o Maples and Calder,  P.O. Box 309,  Grand Cayman,  Cayman
Islands.  The principal  business address for each of GSCP II Germany and GS oHG
is Messeturm Friedrich-Ebert-Anlage 49,60308 Frankfurt am Main, Germany.

Explanation of Responses:

01: Goldman Sachs and GS Group may be deemed to own  beneficially and indirectly
114.452632 shares of Common Stock which were acquired in a privately  negotiated
acquisition by and are beneficially and directly owned by the Greene Street 1998
Exchange Fund,  L.P.  ("Greene  Street  1998").  Goldman Sachs is the investment
manager of Greene Street 1998. An affiliate of Goldman Sachs and GS Group is the
general  partner of Greene Street 1998.  GS Group is the general  partner of and
owns a 99% interest in Goldman Sachs.  The 114.452632  shares reported herein as
indirectly  beneficially  owned by  Goldman  Sachs  and GS Group  represents  GS
Group's  proportionate  interest  in the  shares of the  Issuer  owned by Greene
Street 1998.

02: Goldman Sachs and GS Group may be deemed to own  beneficially and indirectly
150 shares of Common  Stock which are  beneficially  and  directly  owned by the
Greene  Street  Exchange  Fund,  L.P.  ("Greene  Street").  Goldman Sachs is the
investment  manager of Greene Street. An affiliate of Goldman Sachs and GS Group
is the general partner of Greene Street.  GS Group is the general partner of and
owns a 99%  interest  in  Goldman  Sachs.  The 150  shares  reported  herein  as
indirectly beneficially owned by Goldman Sachs and GS Group represent GS Group's
proportionate interest in the shares of the Issuer owned by Greene Street.

03: Goldman Sachs and GS Group may be deemed to own  beneficially and indirectly
in the aggregate  2,276,832  shares of Common Stock  through  GSCPII and certain
other limited  partnerships (the "Other Limited  Partnerships" and together with
GSCP, GSCP II Offshore and GSCP II Germany, the "Limited Partnerships") of which
affiliates  of  Goldman  Sachs and GS Group are the  general  partner,  managing
general partner or managing partner.  Goldman Sachs is the investment manager of
GSCPII.  GS Group is the general  partner of and owns a 99%  interest in Goldman
Sachs.  Goldman  Sachs and GS Group each  disclaim  beneficial  ownership of the
shares of Common Stock owned by the Limited Partnerships except to the extent of
their pecuniary interest therein.

GSCP may be deemed to own beneficially and directly and its general partner,  GS
Advisors,  may be deemed to own beneficially and indirectly  1,428,549 shares of
Common Stock.

GSCP II Offshore may be deemed to own  beneficially and directly and its general
partner,  GS Advisors  Cayman,  may be deemed to own beneficially and indirectly
567,908 shares of Common Stock.

GSCP II Germany may be deemed to own  beneficially and directly and its managing
partner,  GS oHG, may be deemed to own beneficially and indirectly 52,691 shares
of Common Stock.

Each of GS Advisors, GS Advisors Cayman and GS oHG disclaim beneficial ownership
of the securities reported herein except to the extent of its pecuniary interest
in such securities.

SIGNATURES:

GOLDMAN, SACHS & CO.


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact



THE GOLDMAN SACHS GROUP, L.P.


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact



GS CAPITAL PARTNERS II, L.P.


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact


GS CAPITAL PARTNERS II OFFSHORE, L.P.


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact


GS CAPITAL PARTNERS II (GERMANY) CIVIL LAW PARTNERSHIP
(with limitation of liability)


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact


GS ADVISORS, L.P.


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact


GS ADVISORS II (Cayman), L.P.


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact 


GOLDMAN, SACHS & CO. oHG


By:  s/ Roger S. Begelman
     ---------------------
     Name:  Roger S. Begelman
     Title: Attorney-in-fact

Date:  December 10, 1998


**     Intentional misstatements or omissions of facts constitute Federal
       Criminal Violations.

       See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedures.


       Alternatively,   this  Form  is  permitted  to  be  submitted  to  the
       Commission in electronic  format at the option of the reporting person
       pursuant to Rule 101(b)(4) of Regulation S-T.





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