GENZYME TRANSGENICS CORP
10-Q, 1999-05-19
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>



                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                ----------------

                                    FORM 10-Q

   X              QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
- -------
                  SECURITIES EXCHANGE ACT OF 1934

                  For the quarterly period ended April 4, 1999

                                       OR

                  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
                  THE SECURITIES EXCHANGE ACT OF 1934

      For the transition period from ________________ to _________________

                         Commission file number 0-21794

                        GENZYME TRANSGENICS CORPORATION 
           ------------------------------------------------------------
             (Exact name of registrant as specified in its charter)

                        Massachusetts                     04-3186494
- --------------------------------------------------------------------------------
(State or other jurisdiction of                        (I.R.S. Employer
incorporation or organization)                         Identification No.)

Five Mountain Road, Framingham, Massachusetts                  01701
- --------------------------------------------------------------------------------
(Address of principal executive offices)                    (Zip Code)

                                 (508) 620-9700
- --------------------------------------------------------------------------------

               Registrant's telephone number, including area code

Indicate by check whether the registrant (1) has filed all reports required to
be filed by Section 13 or 15 (d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.

         Yes  X  .           No     .
            -----              ----

Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of the latest practicable date.

                  CLASS                              OUTSTANDING AT MAY 7, 1999 
                  -----                              ---------------------------
Common Stock, $0.01 par value                              19,172,009



<PAGE>


                         GENZYME TRANSGENICS CORPORATION
                                TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                                                             PAGE #

<S>                                                                                                         <C>
PART I.  FINANCIAL INFORMATION

         ITEM 1 - Unaudited Condensed Consolidated Financial Statements

         Condensed Consolidated Balance Sheets as of April 4, 1999
         and January 3, 1999.................................................................................3

         Condensed Consolidated Statements of Operations for the Three Months Ended April 4,
         1999 and March 29, 1998 ............................................................................4

         Condensed Consolidated Statements of Cash Flows for
         the Three Months Ended April 4, 1999 and March 29, 1998.............................................5

         Notes to Unaudited Condensed Consolidated Financial Statements......................................6

         ITEM 2
         Management's Discussion and Analysis of
         Financial Condition and Results of Operations.......................................................8

         ITEM 3
         Quantitative and Qualitative Disclosures
         About Market Risk .................................................................................11

PART II. OTHER INFORMATION

         ITEM 2
         Changes in Securities..............................................................................12

         ITEM 6
         Exhibits and Reports on Form 8-K...................................................................12

SIGNATURES..................................................................................................13

EXHIBIT INDEX...............................................................................................14
</TABLE>


                                       2

<PAGE>



                         GENZYME TRANSGENICS CORPORATION
                      CONDENSED CONSOLIDATED BALANCE SHEETS
           (UNAUDITED, DOLLARS IN THOUSANDS EXCEPT PER SHARE AMOUNTS)

<TABLE>
<CAPTION>
                                                                              APRIL 4,   JANUARY 3,
                                                                               1999         1999
                                                                            ----------   ---------
<S>                                                                         <C>          <C>
                                ASSETS
Current assets:
   Cash and cash equivalents                                                 $ 11,528    $ 11,740
   Accounts receivable, net                                                     9,400      12,334
   Unbilled contract revenue                                                    8,899       6,847
   Other current assets                                                         1,579       1,496
                                                                             --------    --------
         Total current assets                                                  31,406      32,417
Net property, plant and equipment                                              31,689      30,486
Costs in excess of net assets acquired, net                                    18,118      18,404
Other assets                                                                    1,728       2,030
                                                                             --------    --------
                                                                             $ 82,941    $ 83,337
                                                                             --------    --------
                                                                             --------    --------
                 LIABILITIES AND STOCKHOLDERS' EQUITY 
Current liabilities:
   Accounts payable                                                          $  2,862    $  2,811
   Accounts payable - Genzyme Corporation                                       1,329       1,487
   Due to ATIII LLC                                                               794       2,418
   Revolving line of credit                                                    15,750      11,096
   Accrued expenses                                                             8,491       8,403
   Advance payments                                                            10,023       8,317
   Current portion of long-term debt                                            2,884       2,204
                                                                             --------    --------
         Total current liabilities                                             42,133      36,736
   Long-term debt, net of current portion                                       9,501       9,561
   Deferred lease obligation
                                                                                  752         741
   Other liabilities
                                                                                   64          95
                                                                             --------    --------
         Total liabilities                                                     52,450      47,133
Stockholders' equity:
    Preferred stock, $.01 par value, 5,000,000 shares authorized;
       4,000,000 have been designated as Series A Convertible, of
       which 18,500 and 20,000 shares are issued and outstanding at
       April 4, 1999 and January 3, 1999, respectively (Note 4)
       (liquidation preference $18,500)                                          --          --
    Common stock, $.01 par value; 40,000,000 shares authorized;
       18,874,392 and 18,384,024 shares issued and outstanding
       at April 4, 1999 and January 3, 1999, respectively                         189         184
    Dividend on preferred stock                                                (1,156)     (1,156)
   Capital in excess of par value - preferred stock                            17,277      18,777
   Capital in excess of par value - common stock                               67,994      65,716
    Unearned compensation                                                        (375)       (437)
   Accumulated deficit                                                        (53,413)    (46,864)
   Accumulated other comprehensive loss                                           (25)        (16)
                                                                             --------    --------
               Total stockholders' equity                                      30,491      36,204
                                                                             --------    --------
                                                                             $ 82,941    $ 83,337
                                                                             --------    --------
                                                                             --------    --------
</TABLE>




The accompanying notes are an integral part of these financial statements.


                                       3

<PAGE>


                         GENZYME TRANSGENICS CORPORATION
                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
               (UNAUDITED, IN THOUSANDS EXCEPT PER SHARE AMOUNTS)



<TABLE>
<CAPTION>
                                                                       THREE MONTHS ENDED
                                                                      APRIL 4,    MARCH 29,
                                                                        1999        1998
                                                                      --------    ---------
<S>                                                                   <C>         <C>     
Revenues
   Services                                                           $ 13,076    $ 11,188
   Sponsored research and development                                    1,693       2,563
                                                                      --------    --------
                                                                        14,769      13,751
Costs and operating expenses:
   Services                                                             11,483       9,921
   Research and development
          Sponsored                                                      2,577       1,841
       Proprietary                                                       1,286       1,839
   Selling, general and administrative                                   4,552       3,886
   Equity in loss of joint venture                                         866         864
                                                                      --------    --------
                                                                        20,764      18,351
                                                                      --------    --------

Loss from operations                                                    (5,995)     (4,600)
Other income (expense):
   Interest income                                                           7          12
   Interest expense                                                       (510)       (457)
                                                                      --------    --------

Loss before income taxes                                                (6,498)     (5,045)

Provision (benefit) for income taxes                                        51         (10)
                                                                      --------    --------

Net loss                                                              $ (6,549)   $ (5,035)
                                                                      --------    --------
                                                                      --------    --------
Dividend to preferred shareholders                                        --        (1,156)
                                                                      --------    --------

Net loss available to common shareholders                             $ (6,549)   $ (6,191)
                                                                      --------    --------
                                                                      --------    --------
Net loss per common share (basic and diluted)                         $  (0.35)   $  (0.35)
                                                                      --------    --------
                                                                      --------    --------
Weighted average number of shares
   outstanding (basic and diluted)                                      18,650      17,466
                                                                      --------    --------
                                                                      --------    --------
Comprehensive loss:
    Net loss                                                            (6,549)     (5,035)
    Other comprehensive income/(loss):
         Unrealized holding losses on available for sale securities         (9)       --
                                                                      --------    --------
    Total other comprehensive income/(loss)                                 (9)       --
                                                                      --------    --------
Comprehensive loss                                                    $ (6,558)   $ (5,035)
                                                                      --------    --------
                                                                      --------    --------
</TABLE>

The accompanying notes are an integral part of these financial statements.


                                       4

<PAGE>


                         GENZYME TRANSGENICS CORPORATION
                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
           (UNAUDITED, DOLLARS IN THOUSANDS EXCEPT PER SHARE AMOUNTS)


<TABLE>
<CAPTION>
                                                                                   THREE MONTHS ENDED
                                                                                 APRIL 4,     MARCH 29,
                                                                                   1999         1998
                                                                                 ---------   -----------
<S>                                                                              <C>         <C>      
Cash flows for operating activities:
   Net loss                                                                      $ (6,549)   $ (5,035)
   Adjustments to reconcile net loss to net cash used by operating activities:
       Depreciation and amortization                                                1,355       1,171
       Amortization of unearned compensation                                           25        --
       Equity in loss of joint venture                                                866         864
       Loss on disposal of fixed assets                                                 1        --
Changes in assets and liabilities:
       Accounts receivable and unbilled contract revenue                              882       3,136
       Inventory and other current assets                                             (93)         15
       Accounts payable                                                                51         617
       Accounts payable - Genzyme Corporation                                        (158)     (1,048)
       Due to ATIII LLC                                                            (2,418)       --
       Other accrued expenses                                                         599        (828)
       Advance payments                                                             1,706        (355)
                                                                                  --------    --------
       Net cash used in operating activities                                       (3,733)     (1,463)
Cash flows for investing activities:
   Purchase of property, plant and equipment                                       (1,548)     (1,718)
   Other assets                                                                       209         (78)
                                                                                 --------    --------
       Net cash used in investing activities                                       (1,339)     (1,796)
Cash flows from financing activities:
   Net proceeds from employee stock purchase plan                                     279         474
   Net proceeds from the exercise of stock options                                     30         369
   Proceeds from preferred stock offering                                            --        19,000
   Proceeds from long-term debt                                                       545        --
   Repayment of long-term debt                                                       (628)       (484)
   Net borrowings (repayment) under revolving line of credit                        4,654      (6,000)
   Investment and advances by Genzyme Corporation                                    --        (6,000)
   Other long-term liabilities                                                        (20)        (23)
                                                                                 --------    --------
       Net cash provided by financing activities                                    4,860       7,336
                                                                                 --------    --------
Net increase (decrease) in cash and cash equivalents                                 (212)      4,077
Cash and cash equivalents at beginning of the period                               11,740       6,383
                                                                                 --------    --------
Cash and cash equivalents at end of period                                       $ 11,528    $ 10,460
                                                                                 --------    --------
                                                                                 --------    --------
Noncash Investing and Financing Activities:
    Property acquired under capital leases                                       $    704    $    385
</TABLE>


The accompanying notes are an integral part of these financial statements.


                                       5

<PAGE>


                GENZYME TRANSGENICS CORPORATION AND SUBSIDIARIES
         NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

         1.       BASIS OF PRESENTATION:

                  These unaudited condensed consolidated financial statements
                  should be read in conjunction with the Company's Annual Report
                  on Form 10-K for the fiscal year ended January 3, 1999 and the
                  financial statements and footnotes included therein. Certain
                  information and footnote disclosures normally included in
                  financial statements prepared in accordance with generally
                  accepted accounting principles have been condensed or omitted
                  pursuant to Securities and Exchange Commission rules and
                  regulations.

                  The financial statements for the three months ended April 4,
                  1999 and March 29, 1998 are unaudited but include, in the
                  Company's opinion, all adjustments (consisting only of
                  normally recurring accruals) necessary for a fair presentation
                  of the results for the periods presented.

         2.       ACCOUNTING POLICIES:

                  The accounting policies underlying the quarterly financial
                  statements are those set forth in Note 2 of the financial
                  statements included in the Company's Annual Report on Form
                  10-K for the year ended January 3, 1999.

                  Per share information is based upon the weighted average
                  number of shares of Common Stock outstanding during the
                  period. Common stock equivalents consisting of warrants,
                  stock options and convertible preferred stock, totaled $6.6
                  million and $4 million at April 4, 1999 and March 29, 1998,
                  respectively. Since the Company was in a net loss position at
                  April 4, 1999 and March 29, 1998, these common stock
                  equivalents were not used to compute diluted loss per share,
                  as the effect was antidilutive.

                  Included in the net loss is an equity in loss of joint venture
                  of $866,000 which represents the Company's commitment to fund
                  its 30% share of the losses incurred in 1999 of the joint
                  venture between the Company and Genzyme Corporation ("ATIII
                  LLC"). Total net losses of the ATIII LLC were $2.9 million and
                  the ATIII LLC did not record any revenues.

         3.       INCOME TAXES:

                  Due to the profitability of some if its contract research
                  laboratories in certain states, the Company has recorded a
                  provision for income taxes for the period ended April 4, 1999.
                  This is solely a provision for state, not federal, income
                  taxes.


                                       6

<PAGE>


         4.       PREFERRED STOCK CONVERSION:

                  On January 25, 1999, an institutional investor converted 1,500
                  shares of the Series A Convertible Preferred Stock ("Preferred
                  Stock"), $.01 par value per share into 321,716 shares of the
                  Company's common stock at a conversion price of $4.6625 per
                  share which represented the average of the five lowest bid
                  prices of the prior 20 trading days before conversion. After
                  this conversion, 18,500 shares of Convertible Preferred Stock
                  remain outstanding as of April 4, 1999.

                  Additionally, on May 4, 1999, an institutional investor
                  converted 1,000 shares of the Preferred Stock into 299,626
                  shares of the Company's stock at a conversion price of $3.3375
                  per share. After this conversion, 17,500 shares of the
                  Convertible Preferred Stock remained outstanding.

         5.       SEGMENT INFORMATION:

                  Below is the Company's segment information for its two
                  reportable segments: contract research organization
                  ("Primedica") and research and development ("Transgenics"). 
                  During 1999, the Company began to allocate certain 
                  corporate expenses to the Primedica segment in its 
                  evaluation of the segment's loss from operations. Certain 
                  reclassifications have been made to prior year's numbers to 
                  conform to 1999 classifications.


<TABLE>
<CAPTION>
                                                         THREE MONTHS ENDED
                                                        APRIL 4,     MARCH 29,
                                                         1999         1998
                                                       ---------  -----------
<S>                                                    <C>         <C>       
Revenues:
   Primedica - external customers                      $ 13,076    $ 11,188  
   Primedica - intersegment                                 431         364
   Transgenics                                            1,693       2,563
                                                       --------    --------
                                                         15,200      14,115
    Elimination of intersegment revenues                   (431)       (364)
                                                       --------    --------
                                                       $ 14,769    $ 13,751
                                                       --------    --------
                                                       --------    --------
Loss from operations:                        
   Primedica                                           $   (893)   $   (902)
   Transgenics                                           (3,256)     (2,040)
   Unallocated amounts:                               
    Corporate expenses                                     (980)       (794)
    Equity in loss of joint venture                        (866)       (864)
                                                       --------    --------
                                                       $ (5,995)   $ (4,600)
                                                       --------    --------
                                                       --------    --------
</TABLE>




                                       7

<PAGE>



               MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
                       CONDITION AND RESULTS OF OPERATIONS

RESULTS OF OPERATIONS

THREE MONTHS ENDED APRIL 4, 1999 AND MARCH 29, 1998

Total revenues for the three-month period ending April 4, 1999 were $14.8
million, compared with $13.8 million in the comparable period of 1998, an
increase of $1 million or 7%. Service revenues increased to $13.1 million in the
first quarter of 1999 from $11.2 million in the first quarter of 1998, an
increase of $1.9 million or 17%. Research and development revenue decreased to
$1.7 million in the first quarter of 1999 from $2.6 million in the first quarter
of 1998, a decrease of $900,000 or 34%. The decrease is a result of a $1 million
milestone payment received in the first quarter of 1998.

Cost of services for the first quarter of 1999 were $11.5 million compared to
$9.9 million in the comparable period of 1998, an increase of $1.6 million or
16% due to the increase in revenues. Sponsored research and development expenses
increased to $2.6 million in the first quarter of 1999 from $1.8 million in the
first quarter of 1998, an increase of $700,000 or 40%. The increase in expense
was due to an increase in activity on sponsored research. Proprietary research
and development expenses decreased to $1.3 million in the first quarter of 1999
from $1.8 in the first quarter of 1998, a decrease of $600,000 or 30%. The
decrease is due to decreased work on the cancer vaccine program and a shifting
of resources to sponsored research and development.

Gross profit, defined as revenues less service costs and research and 
development costs, for the first quarter of 1999 amounted to a loss of 
$577,000 versus a profit of $150,000 in the first quarter of 1998 due to the 
increase in unfunded research and development expenditures. Gross profit on 
services for the first quarter of 1999 was $1.6 million, a gross margin of 
12%, versus $1.3 million, a gross margin of 11%, in the first quarter of 1998.

Selling, general and administrative ("SG&A") expenses increased to $4.6 million
in the first quarter of 1999 from $3.9 million in the first quarter of 1997, an
increase of $700,000 or 17%. The increase is due to the increased marketing
effort and to the addition of administrative personnel required to support the
growth in transgenic research and development programs and additional patent
expenditures.

Interest income decreased to $7,000 in the first quarter of 1999, from $12,000
in the first quarter of 1998, due to lower funds available for investment.
Interest expense increased to $510,000 in the first quarter of 1999 from
$457,000 in the first quarter of 1998 due to increased borrowings in 1999.

The Company recognized $866,000 of joint venture losses incurred on the joint
venture ("ATIII LLC") between the Company and Genzyme Corporation ("Genzyme")
during the first quarter of 1999 as compared to $864,000 incurred during the
first quarter of 1998.


                                       8

<PAGE>



LIQUIDITY AND CAPITAL RESOURCES

The Company had cash and cash equivalents of $11.5 million at April 4, 1999.
During the first three months of 1999, the Company had a $212,000 net decrease
in cash: $3.7 million of cash was used in operations (due primarily to the net
loss of $6.5 million offset by a decrease in non-cash working capital of
$594,000 and $2.2 million of non-cash charges), $1.5 million was invested in
capital equipment, further expansion of the transgenic production facility and
laboratory facilities and $629,000 was used to pay down long-term debt. Sources
of funds during the period included $4.7 million in net borrowings under a
commercial bank revolving line of credit, $545,000 of proceeds from issuance of
long-term debt and $309,000 of proceeds from the issuance of common stock under
various employee stock plans.

The Company had a working capital deficit of $10.7 million at April 4, 1999
compared to a deficit of $4.3 million at January 4, 1999. As of April 4, 1999
the Company had approximately $6.4 million available under the Genzyme
Convertible Debt Agreement, $250,000 available under a line of credit with a
commercial bank, $4.3 million available under various capital lease lines and
$4.7 million available under a term loan for facility expansion. Under the
Company's 1999 operating plan, existing cash balances along with funds available
under the bank and lease lines and the Genzyme Convertible Debt Agreement are
expected to be sufficient to fund the Company through the third quarter of 2000.
The Company is considering various alternative financing strategies, such as
collaborative arrangements, public or private sales of its securities, including
securities in certain subsidiaries, additional mortgage or lease financing,
asset sales and other sources.

Management's current expectations regarding the sufficiency of the Company's
cash resources are forward-looking statements, and the Company's cash
requirements may vary materially from such expectations. Such forward-looking
statements are dependent on several factors, including the results of the
Company's testing services business, the ability of the Company to enter into
any transgenic research and development collaborations in the future and the
terms of such collaborations, the results of research and development and
preclinical and clinical testing, competitive and technological advances and
regulatory requirements. If the Company experiences increased losses, the
Company may have to seek additional financing through collaborative arrangements
or from public or private sales of its securities, including equity securities.
There can be no assurance that additional funding will be available on terms
acceptable to the Company, if at all. If additional financing cannot be obtained
on acceptable terms, to continue its operations the Company could be forced to
delay, scale back or eliminate certain of its research and development programs
or to enter into license agreements with third parties for the commercialization
of technologies or products that the Company would otherwise undertake itself.


                                       9

<PAGE>




IMPACT OF YEAR 2000

Certain companies may face problems if the computer processors and software upon
which they directly or indirectly rely are unable to process date values
correctly upon the turn of the millennium ("Year 2000"). Such a system failure
and corruption of data of the Company or its customers or suppliers could
disrupt the Company's operations, including, among other things a temporary
inability to process transactions or engage in other business activities or to
receive information or services from suppliers.

The Company has appointed a Year 2000 task force to address the issues and
assess the potential impact of the Year 2000 problem. The task force is
evaluating the Company's financial systems, computers, software and other
equipment to ensure that the programs and systems will be Year 2000 compliant.
The Company presently believes that its computer systems, software and other
equipment will be Year 2000 compliant by the Summer of 1999. The Company has
spent approximately $150,000 and estimates that it will spend approximately
$300,000 to $400,000 in capital replacement of computers, equipment and software
upgrades. The Company will incur another $100,000 to $200,000 for costs of
implementation. The Company has initiated communications with third party
suppliers and is requesting that they represent that their products and services
are to be Year 2000 compliant and that they have a program to test for
compliance. Additionally, the Company is assessing those vendors that are not
Year 2000 compliant and is in the process of finding alternative vendors that
are compliant.

Because the Company currently anticipates that it will achieve Year 2000
compliance, it has not formulated a contingency plan. However, should the
Company determine there is significant risk that it may be unable to adhere to
its compliance timetable, it will assess reasonably likely scenarios resulting
from noncompliance and establish a contingency plan to address such scenarios.

The Company's ability to achieve Year 2000 compliance is subject to various
uncertainties including the Company's ability to successfully identify systems
and programs not Year 2000 compliant, the nature and amount of programming
required to correct or replace affected programs, the availability and magnitude
of labor and consulting costs and the success of the Company's business
partners, vendors and clients in addressing the Year 2000 issue. Therefore,
while the financial impact of implementing Year 2000 compliance remediation has
not been and is not anticipated to be material to the Company's business,
financial position or results of operations, the Company can make no assurances
with respect to the costs of remediation efforts not yet incurred. Additionally,
the Company cannot be certain that it will achieve adequate Year 2000 compliance
in a timely manner or that any impact of a failure to achieve such compliance
will not have a material adverse effect on the Company's business, financial
condition or results of operations.


                                       10

<PAGE>




           QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK



There have been no material changes in the Company's market risk since January
3, 1999. The Company's market risk disclosures are discussed in the Genzyme
Transgenics Corporation Form 10-K under the heading Item 7A, Quantitative and
Qualitative Disclosures About Market Risk.


                                       11

<PAGE>




                                     PART II



         ITEM 2:           CHANGES IN SECURITIES

                  On January 25 and May 4, 1999, an institutional investor
         converted 1,500 and 1,000 shares of its Series A Convertible Preferred
         Stock, $.01 par value per share, of the Company (its "Preferred
         Stock"), into 321,716 and 299,626 shares of the Company's Common Stock,
         $.01 par value per share (the "Common Stock"), at conversion prices of
         $4.6625 and $3.3375, respectively. The Company believes the issuance of
         its Common Stock upon conversion of the Preferred Stock qualified as a
         transaction by an issuer not involving a public offering within the
         meaning of Section 4(2) of the Securities Act of 1933, as amended,
         based on the number and nature of the holders.



         ITEM 6:  EXHIBITS AND REPORTS ON FROM 8-K

         (a)      Exhibits

                  See the Exhibit Index immediately following the signature
                  page.

         (b)      Reports on Form 8-K

                  No reports were filed on Form 8-K during the quarter ended
                  April 4, 1999.


                                       12

<PAGE>


                 GENZYME TRANSGENICS CORPORATION AND SUBSIDIARY
                                    FORM 10-Q

                                  APRIL 4, 1999

                                   SIGNATURES

  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  registrant has duly caused this report to be signed on its behalf by the
  undersigned hereunto duly authorized.

  Date: May 19, 1999                 GENZYME TRANSGENICS CORPORATION



                                     BY: /s/ John B. Green
                                        ----------------------------------------
                                              John B. Green
                                              Duly Authorized Officer,
                                              Vice President and
                                              Chief Financial Officer


                                       13

<PAGE>


                                  EXHIBIT INDEX


EXHIBIT                             DESCRIPTION


10                Extension and Modification of Promissory Note, Mortgage,
                  Security Agreement and Loan Agreement dated March 31, 1999, by
                  and between Primedica Redfield, Inc. and Simmons First
                  National Bank. Filed herewith.

27                Financial Data Schedule. (EDGAR only.)



                                       14



<PAGE>

                                                                      EXHIBIT 10

                    EXTENSION AND MODIFICATION OF PROMISSORY
                       NOTE, MORTGAGE, SECURITY AGREEMENT
                               AND LOAN AGREEMENT


         THIS EXTENSION AND MODIFICATION OF PROMISSORY NOTE, MORTGAGE, SECURITY
AGREEMENT and LOAN AGREEMENT ("this Modification and Extension Agreement") made
and entered into by and between Simmons First National Bank, a national banking
association organized and existing under the laws of the United States
("Lender"), and Primedica Redfield, Inc. f/k/a TSI Redfield Laboratories, Inc.,
an Arkansas corporation ("Borrower"), WITNESSETH:

         1. RECITALS. On May 22, 1997, pursuant to a Loan Agreement of even date
("the Loan Agreement"), Lender extended a loan to Borrower in the original sum
of $700,000.00 and to evidence this indebtedness, Borrower executed a Promissory
Note of even date therewith in the original principal amount of $700,000.00
bearing interest and payable as therein set forth ("the Note"). As security for
the Note, Borrower executed a Security Agreement, dated May 22, 1997, covering
certain personal property utilized by Borrower in its business ("the Security
Agreement"). As additional security for the Note, Borrower executed a Mortgage
in favor of the Lender on real property ("the Real Property") located in
Jefferson County, Arkansas ("the Mortgage"), which appears of record in the
records of the Circuit Clerk and Ex-Officio Recorder of Jefferson County,
Arkansas in Book 709, Page 678 as of July 1, 1997. The Loan Agreement, the Note,
the Security Agreement and the Mortgage may hereinafter be referred to as "the
Loan Documents." The payment of the Note is guaranteed by TSI Corporation, Inc.
and Genzyme Transgenics Corporation (jointly, Guarantors") pursuant to
Guaranties dated May 22, 1997 ("the Guaranties"). On or about March 13, 1998,
the Loan Documents were modified pursuant to the Extension and Modification of
Promissory Note, Mortgage, Security Agreement and Loan Agreement ("the Extension
and Modification") dated March 13, 1998, recorded in the Real Estate Records of
Jefferson County, Arkansas in Mortgage Book 728 at Page 518. Hereafter, the
Extension and Modification is included in the reference to the Loan Documents.

         Lender and Borrower, with Guarantors' acknowledgment and consent, have
agreed to extend the maturity date of the Note and modify the provisions of the
Loan Documents, and desire to reduce such modifications to writing herein.

         2. MODIFICATION OF THE NOTE. As of March 17, 1999, the principal
balance of the Note is $606,988.43, plus accrued interest as of March 17, 1999
in the amount of $2,665.76, with interest accruing from March 17, 1999 at the
rate of $166.30 per day. Borrower shall pay or has paid the March 1, 1999
payment. The remaining principal balance of $606,988.43 shall continue to accrue
interest at the rate of nine and one-half per cent (9.50%) per annum, which
amount shall be payable in twenty-six (26) monthly installments of principal
plus accrued interest beginning on April 17, 1999, the first twenty-five (25) of
which shall be in the amount of $9,920.61 each, with the outstanding principal
balance plus accrued interest becoming due with the twenty-sixth (26th) and
final installment on May 17, 2001. In addition to the monthly installment of
principal 

                              Exhibit 10 - page 1

<PAGE>

and interest, Borrower shall pay a monthly amount of $2,035.45, which is
one-twelfth (1/12) of the annual real property taxes dues on the Real Property.

         3. MODIFICATION OF THE LOAN AGREEMENT. THE SECURITY AGREEMENT AND THE
MORTGAGE. The Loan Agreement, the Security Agreement and the Mortgage are
modified to conform to the provisions set forth in this Modification and
Extension Agreement.

         4. OTHER PROVISIONS. Except as herein specifically extended and
modified, all other terms and conditions of the Loan Agreement, the Security
Agreement and the Mortgage shall remain in full force and effect in accordance
with the terms thereof.

         5. ACKNOWLEDGMENT OF GUARANTORS. Guarantors specifically acknowledge
and consent to the terms of this Modification and Extension Agreement.

         IN WITNESS WHEREOF, the parties have executed this instrument on this
31ST day of March, 1999.
                                             LENDER:
                                             SIMMONS FIRST NATIONAL BANK


                                             By: /s/ JOHN W. KELLY
                                                 -------------------------------
                                             Title: Vice President


ATTEST:
/s/ RUSTY BROCKMAN
- ------------------------------------
Title: Asst. Vice President
                                             BORROWER:
                                             PRIMEDICA REDFIELD, INC. f/k/a
                                             TSI REDFIELD LABORATORIES, INC.


                                             By: /s/ JOHN B. GREEN
                                                 -------------------------------
                                             Title: Treasurer
ATTEST:
/s/ LYNNETTE C. FALLON
- ------------------------------------
Title: Secretary


                              Exhibit 10 - page 2

<PAGE>


                                             GUARANTOR:
                                             TSI CORPORATION


                                             By: /s/ JOHN B. GREEN
                                                 -------------------------------
                                             Title: Treasurer
ATTEST:
/s/ LYNNETTE C. FALLON
- ------------------------------------
Title: Secretary


                                             GUARANTOR:
                                             GENZYME TRANSGENICS CORPORATION


                                             By:  /s/ JOHN B. GREEN
                                                 -------------------------------
                                             Title: Vice President
ATTEST:
/s/ LYNNETTE C. FALLON
- ------------------------------------
Title: Clerk


                              Exhibit 10 - page 3

<PAGE>



                                 ACKNOWLEDGMENTS
STATE OF ARKANSAS     )
COUNTY OF JEFFERSON   ) SS

         BE IT REMEMBERED, that on this day appeared in person before me, the
undersigned, a Notary Public within and for the county and state aforesaid, duly
commissioned, qualified and acting, the within named John W. Kelly and Rusty
Brockman to me well known, who stated that they were the Vice President and
Asst. Vice President respectively, of Simmons First National Bank, and that they
were duly authorized in their respective capacities to execute the foregoing
instrument and that they had so executed the same for the consideration and
purposes therein mentioned and set forth, and I do hereby so certify.

         IN TESTIMONY WHEREOF, I have hereunto set my hand and official seal as
such Notary Public this 31st day of March 1999.


                                           /s/ CINDY L. BURNS
                                           -------------------------------------
                                           Notary Public
My commission expires: 11/11/2004


STATE OF ARKANSAS     )
COUNTY OF JEFFERSON   ) SS

         BE IT REMEMBERED, that on this day appeared in person before me, the
undersigned, a Notary Public within and for the county and state aforesaid, duly
commissioned, qualified and acting, the within named John B. Green and Lynnette
Fallon, to me well known, who stated that they were the Treasurer and Secretary,
respectively, of Primedica Redfield, Inc. f/k/a TSI Redfield Laboratories, Inc.,
and that they were duly authorized in their respective capacities to execute the
foregoing instrument and that they had so executed the same for the
consideration and purposes therein mentioned and set forth, and I do hereby so
certify.

         IN TESTIMONY WHEREOF, I have hereunto set my hand and official seal as
such Notary Public this 31st day of March 1999.

                                           /s/ CINDY L. BURNS
                                           -------------------------------------
                                           Notary Public
My commission expires: 11/11/2004


                              Exhibit 10 - page 4

<PAGE>


STATE OF MASSACHUSETTS)
COUNTY OF WORCESTER   )SS

         BE IT REMEMBERED, that on this day appeared in person before me, the
undersigned, a Notary Public within and for the county and state aforesaid, duly
commissioned, qualified and acting, the within named John B. Green, to me well
known, who stated that he is the Treasurer of TSI Corporation, Inc., and that
they were duly authorized in their respective capacities to execute the
foregoing instrument and that they had so executed the same for the
consideration and purposes therein mentioned and set forth, and I do hereby so
certify.

         IN TESTIMONY WHEREOF, I have hereunto set my hand and official seal as
such Notary Public this 31st day of March 1999.

                                           /s/ BRENDA MARTIN
                                           -------------------------------------
                                           Notary Public
My commission expires: 1/28/2005


STATE OF MASSACHUSETTS)
COUNTY OF WORCESTER   )SS

         BE IT REMEMBERED, that on this day appeared in person before me, the
undersigned, a Notary Public within and for the county and state aforesaid, duly
commissioned, qualified and acting, the within named John B. Green, to me well
known, who stated he is Vice President of Genzyme Transgenics Corporation, and
that they were duly authorized in their respective capacities to execute the
foregoing instrument and that they had so executed the same for the
consideration and purposes therein mentioned and set forth, and I do hereby so
certify.
         IN TESTIMONY WHEREOF, I have hereunto set my hand and official seal as
such Notary Public this 31st day of March 1999.


                                           /s/ BRENDA MARTIN
                                           -------------------------------------
                                           Notary Public
My commission expires: 11/28/2005




                              Exhibit 10 - page 5

<PAGE>


                          COMMONWEALTH OF MASSACHUSETTS


County of Suffolk                                                  April 2, 1999



         Then personally appeared the above-named Lynnette C. Fallon, the
Secretary of Primedica Redfield, Inc., the Secretary of TSI Corporation and the
Clerk of Genzyme Transgenics Corporation who acknowledged the foregoing
instrument to be her free act and deed and the free act and deed of said
corporations, before me,


                                           /s/ ROSALYND KAY GULEZIAN
                                           -------------------------------------
                                           Notary Public:
My Commission Expires:     7/1/99


                              Exhibit 10 - page 6



<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<MULTIPLIER>1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          JAN-02-2000
<PERIOD-END>                               APR-04-1999
<CASH>                                          11,528
<SECURITIES>                                         0
<RECEIVABLES>                                   10,008
<ALLOWANCES>                                       608
<INVENTORY>                                        441
<CURRENT-ASSETS>                                31,406
<PP&E>                                          43,062
<DEPRECIATION>                                  11,373
<TOTAL-ASSETS>                                  82,941
<CURRENT-LIABILITIES>                           42,133
<BONDS>                                          9,501
                                0
                                          0
<COMMON>                                           189
<OTHER-SE>                                      30,302
<TOTAL-LIABILITY-AND-EQUITY>                    82,941
<SALES>                                         14,769
<TOTAL-REVENUES>                                14,769
<CGS>                                           15,346
<TOTAL-COSTS>                                   20,764
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 503
<INCOME-PRETAX>                                (6,498)
<INCOME-TAX>                                        51
<INCOME-CONTINUING>                            (6,549)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (6,549)
<EPS-PRIMARY>                                   (0.35)
<EPS-DILUTED>                                   (0.35)
        

</TABLE>


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