<PAGE>
EXHIBIT 4.1.5
FEDERAL IDENTIFICATION
NO. 04-3186494
THE COMMONWEALTH OF MASSACHUSETTS
William Francis Galvin
Secretary of the Commonwealth
One Ashburton Place, Boston, Massachusetts 02108-1512
ARTICLES OF AMENDMENT
(General Laws, Chapter 156B, Section 72)
We, Sandra Nusinoff Lehrman, President, and Lynnette C. Fallon, Clerk,
of Genzyme Transgenics Corporation located at 175 Crossing Boulevard, Suite 410,
Framingham, Massachusetts 01702, certify that these Articles of Amendment
affecting articles numbered: ARTICLE 3 of the Articles of Organization were duly
adopted at a meeting held on May 24, 2000, by vote of 21,999,478 shares of
Common Stock of 28,359,719 shares outstanding being at least a majority of each
type, class or series outstanding and entitled to vote thereon.
To change the number of shares and the par value (if any) of any type,
class or series of stock which the corporation is authorized to issue, fill in
the following:
The total presently authorized is:
<TABLE>
<CAPTION>
=================================================== ================================================================
WITHOUT PAR VALUE STOCKS WITH PAR VALUE STOCKS
----------------------- --------------------- ---------------------- ------------------- ---------------------------
TYPE NUMBER OF SHARES TYPE NUMBER OF SHARES PAR VALUE
----------------------------- --------------------- ---------------------- ------------------- ---------------------
<S> <C> <C> <C> <C>
Common: Common: 40,000,000 $0.01
----------------------------- --------------------- ---------------------- ------------------- ---------------------
----------------------------- --------------------- ---------------------- ------------------- ---------------------
Preferred: Preferred: 5,000,000 $0.01
----------------------------- --------------------- ---------------------- ------------------- ---------------------
=================================================== ================================================================
</TABLE>
Change the total authorized to:
<TABLE>
<CAPTION>
=============================================== ====================================================================
WITHOUT PAR VALUE STOCKS WITH PAR VALUE STOCKS
----------------------------------------------- --------------------------------------------------------------------
TYPE NUMBER OF SHARES TYPE NUMBER OF SHARES PAR VALUE
------------------------ ---------------------- ---------------------- ---------------------- ----------------------
<S> <C> <C> <C>
Common: Common: 100,000,000 $0.01
------------------------ ---------------------- ---------------------- ---------------------- ----------------------
------------------------ ---------------------- ---------------------- ---------------------- ----------------------
Preferred: Preferred: 5,000,000 $0.01
<PAGE>
------------------------ ---------------------- ---------------------- ---------------------- ----------------------
======================== ====================== ====================== ====================== ======================
</TABLE>
The foregoing amendment(s) shall become effective when these Articles
of Amendment are filed in accordance with General Laws, Chapter 156B, Section 6,
unless these articles specify, in accordance with the vote adopting the
amendment, a later effective date not more than thirty days after such filing,
in which event the amendment will become effective on such later date.
Later effective date: __________________________
SIGNED UNDER THE PENALTIES OF PERJURY, this 24th day of May, 2000.
/S/ SANDRA NUSINOFF LEHRMAN, PRESIDENT
--------------------------------------
/S/ LYNNETTE C. FALLON, CLERK
-----------------------------
