FIRST TRUST SPECIAL SITUATIONS TR SER 72 MIDWST THRIFT SER 2
485BPOS, 1997-09-30
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                                  S-1


                                                File No. 33-63668


               SECURITIES AND EXCHANGE COMMISSION
                   WASHINGTON, D.C. 20549-1004
                                
                         POST-EFFECTIVE
                         AMENDMENT NO. 4
                                
                               TO
                                
                            FORM S-6

For Registration Under the Securities Act of 1933 of Securities
of Unit Investment Trusts Registered on Form N-8B-2


       THE FIRST TRUST SPECIAL SITUATIONS TRUST, SERIES 72
                      (Exact Name of Trust)
                                
                      NIKE SECURITIES L.P.
                    (Exact Name of Depositor)
                                
                      1001 Warrenville Road
                     Lisle, Illinois  60532
                                
  (Complete address of Depositor's principal executive offices)
                                


          NIKE SECURITIES L.P.     CHAPMAN AND CUTLER
          Attn:  James A. Bowen    Attn:  Eric F. Fess
          1001 Warrenville Road    111 West Monroe Street
          Lisle, Illinois  60532   Chicago, Illinois  60603


        (Name and complete address of agents for service)

It is proposed that this filing will become effective (check
appropriate box)

:____:    immediately upon filing pursuant to paragraph (b)
:__X_:    September 30, 1997
:____:    60 days after filing pursuant to paragraph (a)
:____:    on (date) pursuant to paragraph (a) of rule (485 or
486)
Pursuant to Rule 24f-2 under the Investment Company Act of  1940,
the issuer has registered an indefinite amount of securities.   A
24f-2 Notice for the offering was last filed on July 21, 1997.

              CONTENTS OF POST-EFFECTIVE AMENDMENT
                    OF REGISTRATION STATEMENT
                                
This Post-Effective Amendment of Registration Statement comprises
the following papers and documents:

                          The facing sheet

                          The purpose of the Amendment

                          The signatures




                  THE PURPOSE OF THE AMENDMENT
The  purpose  of  this amendment is to terminate the  declaration
made  pursuant  to  Rule 24f-2 promulgated under  the  Investment
Company Act of 1940, as amended, because Units of The First Trust
Special  Situations Trust, Series 72 are no longer being  offered
for sale in the secondary market.  A final Rule 24f-2 Notice with
respect  to  such  series has been filed concurrently  with  this
filing.










                               S-1
                           SIGNATURES
Pursuant  to the requirements of the Securities Act of 1933,  the
Registrant, The First Trust Special Situations Trust, Series  72,
certifies that it meets all of the requirements for effectiveness
of  this Registration Statement pursuant to Rule 485(b) under the
Securities  Act  of 1933 and has duly caused this  Post-Effective
Amendment  of  its  Registration Statement to be  signed  on  its
behalf  by  the  undersigned thereunto  duly  authorized  in  the
Village of Lisle and State of Illinois on September 30, 1997.

THE FIRST TRUST SPECIAL SITUATIONS TRUST, SERIES 72
                                                             (Registrant)
                          By     NIKE SECURITIES L.P.
                                                              (Depositor)


                          By     Robert M. Porcellino
                                 Senior Vice President

Pursuant to the requirements of the Securities Act of 1933,  this
Post-Effective  Amendment  of  Registration  Statement  has  been
signed  below by the following person in the capacity and on  the
date indicated:

Signature                  Title*                  Date

Robert D. Van Kampen  Sole Director of      )
                      Nike Securities       )
                     Corporation, the       )
                      General Partner       ) September 30, 1997
                  of Nike Securities L.P.   )
                                            )
                                            )
                                            )Robert M. Porcellino
                                            )Attorney-in-Fact**


*The title of the person named herein represents his capacity  in
and relationship to Nike Securities L.P., the Depositor.

**An executed copy of the related power of attorney was filed  wi
th  the  Securities  and Exchange Commission in  connection  with
Amendment No. 1 to Form S-6 of The First Trust Special Situations
Trust,  Series  18  (File No. 33-42683) and the  same  is  hereby
incorporated herein by this reference.

                               S-2
                 CONSENT OF INDEPENDENT AUDITORS
                                
We  consent  to  the  reference to our  firm  under  the  caption
"Experts" and to the use of our report dated August 29,  1997  in
this  Post-Effective Amendment to the Registration Statement  and
related  Prospectus of The First Trust Special  Situations  Trust
dated September 25, 1997.



                                             ERNST & YOUNG LLP




Chicago, Illinois
September 24, 1997



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