INHALE THERAPEUTIC SYSTEMS INC
10-K, 2000-03-10
PHARMACEUTICAL PREPARATIONS
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549
                            ------------------------

                                   FORM 10-K

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<C>        <S>
   /X/     ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
           SECURITIES ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER
           31, 1999 OR
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<TABLE>
<C>        <S>
   / /     TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
           SECURITIES EXCHANGE ACT OF 1934.
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                          COMMISSION FILE NO. 0-23556
                            ------------------------

                        INHALE THERAPEUTIC SYSTEMS, INC.

             (Exact name of registrant as specified in its charter)

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<S>                                            <C>
               DELAWARE                                     94-3134940
    (State or other jurisdiction of                      (I.R.S. Employer
    incorporation or organization)                     Identification No.)
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                   150 INDUSTRIAL ROAD, SAN CARLOS, CA 94070
             (Address of principal executive offices and zip code)

                                 (650) 631-3100
              (Registrant's telephone number, including area code)
                            ------------------------

Securities registered pursuant to Section 12(b) of the Act: NONE

Securities registered pursuant to Section 12(g) of the Act: COMMON STOCK,
$0.0001 PAR VALUE

    Indicate by check mark whether the Registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
Registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. Yes /X/  No / /

    Indicate by check mark if disclosure of delinquent filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to the
best of Registrant's knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. / /

    The approximate aggregate market value of voting stock held by
non-affiliates of the Registrant, based upon the last sale price of the Common
Stock on March 1, 2000 as reported by Nasdaq National Market was approximately
$1,860,035,885. Determination of affiliate status for this purpose is not a
determination of affiliate status for any other purpose.

                                   20,588,388

       (Number of shares of common stock outstanding as of March 1, 2000)
                            ------------------------

                      DOCUMENTS INCORPORATED BY REFERENCE

Portions of Registrant's definitive Proxy Statement to be filed for its 2000
Annual Meeting of Shareholders are incorporated by reference into Part III
hereof.

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                        INHALE THERAPEUTIC SYSTEMS, INC.
                        1999 ANNUAL REPORT ON FORM 10-K
                               TABLE OF CONTENTS

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PART I
  Item 1. Business..........................................      1
  Item 2. Properties........................................     26
  Item 3. Legal Proceedings.................................     27
  Item 4. Submission of Matters to a Vote of Security
    Holders.................................................     27
PART II
  Item 5. Market for Registrant's Common Equity and Related
    Shareholder Matters.....................................     27
  Item 6. Selected Financial Data...........................     30
  Item 7. Management's Discussion and Analysis of Financial
    Condition and Results of Operations.....................     31
  Item 7A. Quantitative and Qualitative Disclosures about
    Market Risk.............................................     35
  Item 8. Financial Statements and Supplementary Data.......     35
  Item 9. Changes in and Disagreements with Accountants on
    Accounting and Financial Disclosure.....................     35
PART III
  Item 10. Directors and Executive Officers of the
    Registrant..............................................     36
  Item 11. Executive Compensation...........................     39
  Item 12. Security Ownership of Certain Beneficial Owners
    and Management..........................................     39
  Item 13. Certain Relationships and Related Transactions...     39
PART IV
  Item 14. Exhibits, Financial Statement Schedules, and
    Reports on Form 8-K.....................................     40
SIGNATURES..................................................     43
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                                     PART I

ITEM 1. BUSINESS

OVERVIEW

    Inhale Therapeutic Systems, Inc. ("Inhale") is creating a drug delivery
system to easily and painlessly deliver a wide range of drugs, including
peptides, proteins, nucleic acids and other molecules, by inhalation to the deep
lung for treatment of systemic and respiratory diseases. Inhale is using this
system principally to enable non-invasive delivery of protein drugs currently
administered by injection. Inhale's most advanced program, which is sponsored by
Pfizer Inc. ("Pfizer"), is inhaleable insulin. Pfizer commenced dosing for its
Phase III clinical trials in June 1999. In addition to its insulin program with
Pfizer, Inhale has development collaborations with Biogen, Inc., Aventis Behring
L.L.C. (formerly Centeon L.L.C., a joint venture of Hoechst AG and Rhone-Poulenc
S.A., which have now merged to form Aventis S.A.), and Eli Lilly & Co. Inhale
also has early stage feasibility and research collaborations with several other
companies and has tested seven drugs in clinical trials.

    Currently there are approximately 35 macromolecule drugs marketed in the
United States and about 120 other such drugs in clinical trials. Sales of the
top 15 genetically engineered protein drugs (a subset of macromolecule drugs)
were estimated at $14 billion worldwide in 1997. Most of these drugs are
currently delivered by injection. Injections are undesirable for numerous
reasons including patient discomfort, inconvenience and risk of infection. Poor
patient acceptance of, and compliance with, injectable therapies can lead to
increased incidence of medical complications and higher disease management
costs. Alternatives to injection such as oral, transdermal and nasal delivery
have to date been commercially unattractive due to low natural
bioavailability--the amount of drug absorbed from the delivery site into the
bloodstream relative to injection. As an alternative to the invasiveness of
injection, Inhale believes a deep lung inhalation delivery system could expand
the market for protein drug therapies by increasing patient acceptance and
improving compliance and may enable new therapeutic uses of certain protein
drugs.

    Inhale is creating a proprietary platform integrating customized
formulation, dry powder processing and packaging with a proprietary inhalation
device to enable efficient, reproducible delivery of drugs for systemic and
local lung indications. For specific drug products, Inhale formulates and
processes bulk drugs supplied by collaborative partners into dry powders which
are packaged into individual dosing units referred to as blisters. The blisters
are designed to be loaded into Inhale's device, which patients then activate to
inhale the aerosolized drugs. Inhale has developed an inhalation device that is
being used several times per day for several months in outpatient trials for
insulin. In addition, Inhale has demonstrated room temperature stability of a
year or more for a number of protein drugs, and has scaled-up its powder
processing and packaging for late stage clinical trials and small scale
production for certain drugs.

    As an alternative to invasive delivery techniques, Inhale believes that a
deep lung delivery system could potentially expand the market for protein drug
therapies by increasing patient acceptance and improving compliance, which in
turn could decrease medical complications and the associated costs of disease
management. Additionally, deep lung delivery may enable new therapeutic uses of
certain protein drugs. Inhale is focusing development efforts on applying its
pulmonary delivery system primarily to drugs for systemic and local lung
diseases that either have proven efficacy and are approved for delivery by
injection or are in late stage clinical trials.

    A cornerstone of Inhale's business strategy is to work with collaborative
partners to develop and commercialize drugs for deep lung delivery. In a typical
collaboration, Inhale's partner will support the application of Inhale's
technology to a particular drug by providing the drug, funding clinical
development, and marketing the resulting commercial product. Inhale typically
will supply the delivery system and receive research and development and
progress payments during development, and receive revenues from powder
manufacturing, device supply, and royalties from sales of any commercial
products.

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    In addition to Pfizer's sponsorship of the inhaleable insulin program,
Inhale has active development programs with several other corporate partners.
Inhale's most recent collaboration is with Biogen for pulmonary delivery of
Interferon-Beta-1a, sold under the trade name AVONEX-Registered Trademark-, the
leading drug worldwide for the treatment of Multiple Sclerosis. Inhale is also
engaged in development collaborations with Aventis Behring on alpha-1 proteinase
inhibitor for genetic emphysema, and with Lilly for an undisclosed protein drug.
Inhale is also engaged in early stage feasibility and research programs with
respect to other compounds. Inhale anticipates that any product that may be
developed would be commercialized with a collaborative partner and believes its
partnering strategy will enable it to reduce the investment required to develop
a large and diversified potential product portfolio.

    In late 1999, Inhale completed the sale of approximately $108.5 million
aggregate principal amount of 6 3/4% Convertible Subordinated Debentures due
October 13, 2006. In early 2000, the Company entered into agreements with
certain holders of these outstanding debentures to convert their debentures into
common stock in exchange for a cash payment. To date, the Company has agreed to
make cash payments of approximately $16.2 million in the aggregate in connection
with agreements that provide for the conversion of approximately $94.2 million
aggregate principal amount of outstanding debentures into approximately
2.9 million shares of common stock. Such amounts will be reflected as a charge
to interest expense in the first quarter of 2000.

    In February 2000, Inhale received approximately $222.4 million in net
proceeds from the issuance of $230.0 million aggregate principal amount of
convertible subordinated notes to certain qualified institutional buyers under
Rule 144A of the Securities Act of 1933, as amended. Interest on the notes will
accrue at a rate of 5.0% per year, subject to adjustment in certain
circumstances. The notes will mature in 2007 and are convertible into shares of
Inhale's common stock at a conversion price of $76.71 per share, subject to
adjustment in certain circumstances.

    Upon completion of the issuance of the February 2007 notes and the exchange
of the October 2006 debentures, the Company expects to net approximately
$206.2 million cash.

OPPORTUNITY FOR PULMONARY DRUG DELIVERY

MACROMOLECULES

    Innovations in biotechnology and recombinant techniques have led to a large
increase in the number of macromolecule drugs over the last several years. These
drugs, which are identical or similar to the body's natural molecules, are
enabling new therapies for many previously untreated or poorly treated diseases.
Currently, approximately 35 biotechnology drugs are approved for marketing in
the United States and approximately 120 additional biotechnology drugs are in
clinical trials, many for chronic and subchronic diseases. Sales of genetically
engineered protein drugs were estimated at $14 billion worldwide in 1997.

    There are five typical routes of administration of drugs, four natural and
one which bypasses natural barriers to entry of molecules into the body. The
four natural routes are through the digestive tract (oral), the skin
(transdermal), the mucosal surfaces (nasal and sublingual), and the lung
(inhalation). Penetration of the skin by injection (subcutaneous, intramuscular,
or intravenous) bypasses the major natural barrier to prevent molecules from
entering the body.

    Oral delivery is a common method of delivery for many small molecule drugs.
However, macromolecules are typically extremely vulnerable to digestion and
therefore are very poorly delivered by an oral route. In addition, Inhale
believes that dosage reproducibility for oral delivery of macromolecules may be
very poor because of their low oral bioavailability. While several companies are
working on oral delivery for macromolecule drugs, no commercially viable system
is currently being marketed.

    The size of most macromolecules makes penetration of the skin inefficient or
ineffective. Passive transdermal delivery using "patch" technology has not been
successful to date since the skin is less

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naturally permeable to macromolecules than the gastrointestinal tract. No
macromolecule drugs have been approved for marketing in the United States
utilizing patch technology. Certain peptides and proteins can be transported
across the skin barrier into the bloodstream using high pressure "needle-less"
injection devices. The devices, which inject proteins like insulin through the
skin into the body, have been available for many years. However, Inhale believes
these devices have not been well accepted due to patient discomfort and
relatively high cost.

    The nasal route of drug administration has been limited by low and variable
bioavailability for proteins and peptides. As a result of these limitations,
penetration enhancers are often used with nasal delivery to achieve higher
bioavailability. These enhancers may cause local irritation to the nasal tissue
and result in safety concerns with long-term use. Only a limited number of
peptides have been approved for marketing in the United States utilizing nasal
delivery. Inhale believes these same obstacles will affect sublingual drug
delivery, which also relies on the penetration of similar tissue in the mouth.

    The principal practical and efficient route of administration of
macromolecules, particularly recombinant proteins, has been injections.. Drug
injections administered in hospitals or doctors' offices can be expensive and
inconvenient to patients. Many patients find self-injectable therapies
unpleasant. As a result, such therapies for many chronic and subchronic diseases
meet with varying degrees of patient acceptance and compliance with the
prescribed regimens. Poor acceptance and compliance can lead to increased
incidence of medical complications and potentially higher disease management
costs. In addition, some elderly, infirm or pediatric patients cannot administer
their own injections and require assistance, thereby increasing both
inconvenience to these patients and the cost of therapy.

    Delivery of drugs to the lungs via inhalation (pulmonary delivery) has the
potential to be a much more effective route of administration of macromolecules,
with a relatively higher absorption into the bloodstream (bioavailability) than
all alternative routes except injection. As an alternative to the invasiveness
of injection, Inhale believes a deep lung inhalation delivery system could
increase patient acceptance and improve compliance and may enable new
therapeutic uses of certain macromolecule drugs. Pulmonary delivery is already
in use for a variety of small molecule drugs.

    Existing pulmonary drug delivery systems such as metered-dose inhalers
("MDIs"), dry powder inhalers and nebulizers, are used primarily to deliver
drugs to the upper airways of the lung for lung diseases. Approximately 35 drugs
are approved for marketing by the FDA for delivery into the respiratory tract,
but none of these pulmonary drug delivery devices were designed to optimize drug
delivery to the deep lung for absorption into the bloodstream. MDIs, dry powder
inhalers and nebulizers typically deliver only a fraction of the drug to the
deep lung, with most of the drug being lost in the delivery device or in the
mouth and throat. Consequently, Inhale believes that the total efficiency of
such systems is generally not high enough to be commercially feasible for
systemic delivery of most macromolecule drugs.

    In addition, pulmonary drug delivery devices currently do not provide the
dosage reproducibility and formulation stability generally needed for
commercially viable systemic macromolecule drug delivery. Inhale believes that
many MDI and dry powder systems do not provide the deep lung dosage
reproducibility necessary for many systemic applications because the patient
must coordinate the breathing maneuver with the generation of the aerosol.
Further, Inhale believes that many macromolecules currently cannot be formulated
for use in MDI systems, since macromolecule drugs could be denatured by the MDI
formulating ingredients. In addition, Inhale believes that some macromolecules
may be inactivated by nebulization and that many dry powder systems do not
provide the protection needed for long-term stability that may be needed for
macromolecule formulations.

    Inhale believes that an efficient and reproducible deep lung delivery system
for systemic macromolecule drugs used in the treatment of chronic and subchronic
diseases represents a significant commercial opportunity. Such a system could
improve patient acceptance of systemic macromolecule drug therapy and compliance
with prescribed regimens, thereby improving therapeutic outcomes and reducing

                                       3
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the costs of administration and treatment of disease. Additionally, pulmonary
delivery may enable new therapeutic uses of certain macromolecule drugs.

    Inhale also believes that opportunities for a deep lung delivery system
exist in the delivery of macromolecules for local lung diseases due to the
limitations of current pulmonary devices. Biotechnology and pharmaceutical
companies are developing new macromolecule drugs for pulmonary diseases such as
asthma, cystic fibrosis, emphysema, lung cancer, pneumonia and bronchitis.
Pulmonary delivery is the preferred route for treating most lung diseases since
application of the drug directly to the site of action (lung) requires much less
drug than systemic administration, thereby potentially reducing systemic side
effects.

OTHER MOLECULES

    In addition to developing a deep lung delivery system for macromolecules,
Inhale is investigating opportunities for leveraging its technology for
application to small molecules where there is a clear, demonstrable need for an
alternative drug delivery system and where Inhale's existing technology can be
applied without significant modification. Examples include molecules that
require rapid systemic absorption for efficacy (i.e., analgesics and
antiemetics), molecules that undergo massive first pass metabolism by the oral
route or molecules used for local lung delivery for diseases such as asthma that
are currently delivered by sub-optimal aerosol systems.

    MDIs, existing dry powder inhalers and nebulizers have been used primarily
to deliver drugs to the upper airways of the lung for local lung applications.
Some of the problems associated with traditional small molecule aerosol delivery
systems include poor reproducibility, low efficiency, low drug payload per puff,
poor moisture barrier and, in the case of wet systems, long dosing time and
potential for microbial growth.

    Inhale believes that its technology could be used to address these problems
by providing efficient dispersion of the drug into the lungs resulting in the
reproducible delivery of a consistent amount of drug into the bloodstream.
Inhale further believes its technology could potentially be applied economically
in market segments where it is essential that significant drug doses reach the
lung. Large amounts of drugs taken orally or through inefficient inhalers can
result in side effects which could be avoided or reduced through more efficient
and better targeted pulmonary delivery.

STRATEGY

    Inhale's goal is to become the leading drug delivery company in the field of
pulmonary delivery of macromolecules. In addition, Inhale is leveraging its
technology base for other applications where its system can provide significant
market advantages. Inhale's strategy incorporates the following principal
elements:

    - DEVELOP A BROADLY APPLICABLE PULMONARY DELIVERY SYSTEM. Inhale is
      developing its non-invasive deep lung drug delivery system to be
      applicable to a wide range of peptides, proteins and other molecules
      currently delivered by injection or poorly delivered by inhalation or
      other routes. Inhale intends to develop effective non-invasive delivery
      alternatives that can: (1) expand market penetration for existing
      therapeutics currently delivered by injection, infusion or other routes;
      (2) commercialize new indications by using deep lung delivery as a new
      route of administration; and (3) extend existing patents or seek new
      patents to gain important competitive advantages for Inhale and its
      partners.

    - BUILD COMPETITIVE ADVANTAGE THROUGH AN INTEGRATED SYSTEMS APPROACH. Inhale
      is developing a commercially viable deep lung delivery system through an
      integrated systems solution. Inhale combines its expertise in pulmonary
      physiology and biology, aerosol science, powder science, chemical
      engineering, mechanical engineering and product design, protein
      formulation, fine powder processing and filling to build a proprietary,
      fully-integrated system for pulmonary delivery of therapeutic

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      drugs. Inhale believes that building expertise in technology across
      several disciplines provides it with a significant competitive advantage.

    - PARTNER WITH PHARMACEUTICAL AND BIOTECHNOLOGY COMPANIES.Inhale's strategy
      is to market its proposed products through collaborative partners. Inhale
      is seeking to work with partners that have significant clinical
      development and marketing resources, and currently has collaborations with
      several large pharmaceutical and biotechnology companies. For patented
      drug products, Inhale intends to partner with owners or licensees from the
      outset of the project. For drugs that are off-patent or licensed-in,
      Inhale may perform initial feasibility screening work, formulations
      development and early stage clinical trials before entering into a partner
      relationship for further development. Inhale believes this partnering
      strategy enables it to reduce its cash requirements while developing a
      large and diversified potential product portfolio.

    - FOCUS ON APPROVED OR LATE STAGE DRUGS. To date, Inhale has focused
      primarily on drugs that either have proven efficacy and are approved for
      marketing or are in late stage clinical trials. Inhale believes that
      working primarily with drugs with demonstrated efficacy reduces the
      technical risk of its projects. In the future, Inhale anticipates working
      on drugs at earlier stages of development.

    - EXPAND MANUFACTURING CAPABILITY. Inhale intends to formulate, manufacture
      and package dry powders for most of its drugs and to subcontract
      manufacturing of its device. Inhale believes that this strategy will
      provide manufacturing economies of scale across a range of therapeutic
      products and expand capacity for additional partnerships and commercial
      scale production.

INHALE'S DEEP LUNG DRUG DELIVERY SYSTEM

    Inhale believes that the following criteria are necessary for a commercially
viable non-invasive deep lung drug delivery system:

    - SYSTEM EFFICIENCY/COST: The system must attain a certain minimum
      efficiency in delivering a drug to the bloodstream as compared to
      injection. Bioavailability (the percentage of drug absorbed into the
      bloodstream from the lungs relative to that absorbed from injection) is
      the most important element of system efficiency. Total system efficiency
      is critical due to the high cost of macromolecule drugs. Total delivery
      system efficiency is determined by the amount of drug loss during
      manufacture, in the delivery device, in reaching the site of absorption,
      and during absorption from that site into the bloodstream. Inhale believes
      that for most systemic macromolecule drugs, a non-invasive delivery system
      must show total delivery system efficiency of at least 5% to 25% compared
      to injection for the system to be commercially viable.

    - REPRODUCIBILITY: The system must deliver a consistent and predictable
      amount of drug to the lung and into the bloodstream.

    - FORMULATION STABILITY: Formulations used in the system must remain
      physically and chemically stable over time and under a range of storage,
      shipping and usage conditions.

    - SAFETY: The system should not introduce local toxicity problems during
      chronic or subchronic use by a wide population of patients.

    - CONVENIENCE: The system must be convenient to the patient in terms of
      comfort, ease of operation, transportability and required dosage time.

    Inhale approaches pulmonary drug delivery with the objective of maximizing
overall delivery system efficiency while addressing commercial requirements for
reproducibility, formulation stability, safety and convenience. To achieve this
goal, Inhale's delivery system integrates customized drug formulations and
packaging with its proprietary inhalation device. Inhale combines an
understanding of lung biology, aerosol science, chemical engineering, mechanical
engineering and protein formulations in its system development efforts. Inhale
believes that this interdisciplinary capability provides an important
competitive advantage.

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    Inhale has chosen to base its deep lung delivery system on dry powders for
several reasons. Many proteins are more stable in dry powders than in liquids.
In addition, dry powder aerosols can carry approximately five times more drug in
a single breath than typical MDIs and, for many drugs, at least 25 times more
than currently marketed liquid or nebulizer systems. Inhale believes that a dry
powder system for drugs requiring higher doses, such as insulin and alpha-1
proteinase inhibitor, could decrease dosing time as compared with nebulizers.

    Inhale takes bulk drugs supplied by partners and formulates and processes
them into fine powders that are then packaged into individual blisters. The
blisters are designed to be loaded into Inhale's device, which patients activate
to inhale the aerosolized drugs. Once inhaled, the aerosol particles are
deposited in the deep lung, dissolved in the alveolar fluid and absorbed into
the bloodstream. Although Inhale is in the advanced stages of developing its
system technologies, there can be no assurance that Inhale's products will ever
be successfully commercialized.

FORMULATIONS

    Each macromolecule drug poses different formulation challenges due to
differing chemical and physical characteristics and dosing requirements. This
requires significant optimization work for each specific drug. Inhale has
assembled a team with expertise in protein formulation, powder science and
aerosol science and is applying this expertise to develop proprietary techniques
and methods that it believes will produce stable, fillable and dispersible dry
powder drug formulations. Inhale has developed several protein powders which
remain stable at room temperature in excess of one year. Through its work with
numerous macromolecules, Inhale is developing an extensive body of knowledge on
aerosol dry powder formulations, including knowledge relating to powder flow
characteristics and solubility within the lung, as well as physical and chemical
properties of various excipients. Inhale has filed and expects to continue to
file patent applications on several of its formulations and, through strategic
acquisitions, has acquired rights to certain U.S. and foreign patents and patent
applications relating to stabilization of macromolecule drugs in dry
formulations.

POWDER PROCESSING

    Inhale is modifying standard powder processing equipment and developing
custom techniques to enable it to produce fine dry powders with particle aerosol
diameters of between one and five microns without degradation or significant
loss of expensive bulk drug. Inhale has scaled up powder processing to levels
sufficient for producing test powders for late stage clinical trials and small
volume marketed products. Inhale is in the process of further scaling up its
powder processing systems in order to produce quantities sufficient for
commercial production of products Inhale believes it will need to supply in high
volumes, such as insulin. However, there can be no assurance that Inhale will be
successful in further scaling up its powder processing on a timely basis or at a
reasonable cost, or that the powder processing system will be applicable for
every drug.

POWDER FILLING AND PACKAGING

    Powders made up of fine particles that do not behave in a granularly flowing
way, are generally compressible, and hence require handling that is different
than for powders comprised of larger particles. Currently available commercial
filling and packaging systems are designed for filling powders of larger
particle size and therefore must be re-engineered to dispense finer powders
accurately and in the small quantities often required. Initially, during early
stages of development, powder filling was performed manually. Inhale has since
developed and qualified a proprietary automated filling system suitable for use
in production of clinical trial supplies and commercial quantities for certain
products. Inhale is further developing a high through-put system for use with
products whose market requirements dictate increased capacity.

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INHALATION DEVICE

    Inhale's proprietary pulmonary delivery device is designed to provide deep
lung delivery of therapeutic powders in a reproducible, safe and efficient
manner. The first of a series of patents applied for covering the device was
granted in the United States in October 1995. To achieve its objectives, Inhale
has designed its pulmonary delivery device to perform the following:

    - EFFECTIVELY DISPERSE FINE PARTICLES INTO AN AEROSOL CLOUD. Fine powders
      have different dispersion requirements or characteristics than large
      powders. Most current dry powder inhalers use larger powders and are not
      efficient in dispersing powders with aerosol diameters of one to five
      microns. Inhale has developed and is refining its dispersion system for
      its device specifically for fine powders. Inhale's device has been
      designed to efficiently remove powders from the packaging, effectively
      break up the powder particles and create an aerosol cloud while
      maintaining the integrity of the drug.

    - EFFICIENTLY AND REPRODUCIBLY DELIVER THE AEROSOL CLOUD TO THE DEEP LUNG.
      Inhale is developing a proprietary aerosol cloud handling system in its
      device that is intended to facilitate deep lung powder deposition and
      reproducible patient dosing. The handling system design is intended to
      enable the aerosolized particles to be transported from the device to the
      deep lung during a patient's breath, reducing losses in the throat and
      upper airways. In addition, the aerosol cloud handling system, in
      conjunction with the dispersion mechanism and materials used in the
      device, is designed to reduce powder loss in the device itself.

    - ELIMINATE THE USE OF PROPELLANTS TO AVOID ASSOCIATED ENVIRONMENTAL
      CONCERNS AND FORMULATION DIFFICULTIES. Unlike MDIs, the Inhale device does
      not use propellants. The oily surfactants required to stabilize propellant
      formulations can cause aggregation of macromolecules. Current
      chlorofluorocarbon propellants, which are used in most commercial MDI
      systems, are being phased out in many countries due to environmental
      concerns.

    The success of Inhale's deep lung drug delivery system for any drug will
depend upon Inhale achieving sufficient formulation stability, safety dosage
reproducibility and total system efficiency (measured by the percentage of bulk
drug entering the manufacturing process that eventually is absorbed into the
bloodstream relative to injection for systemic indications, or the amount of
drug delivered to the lung tissue for local lung indications). The initial
screening determinant for the feasibility of pulmonary delivery of any systemic
drug is pulmonary bioavailability, which measures the percentage of the drug
absorbed into the bloodstream when delivered directly to the lungs. In addition,
a certain percentage of each drug dose may be lost at various stages of the
manufacturing process, (e.g., in drug formulation, dry powder processing, or
powder filling and packaging) and in moving the drug from a delivery device into
the lungs. Excessive drug loss at any one stage or cumulatively in the
manufacturing and delivery process would render a drug commercially unfeasible
for pulmonary delivery. Formulation stability (the physical and chemical
stability of the formulated drug over time and under various storage, shipping
and usage conditions) and safety will vary with each macromolecule and the type
and amount of excipients, that are used in the formulation. Dose reproducibility
(the ability to deliver a consistent and predictable amount of drug into the
bloodstream over time both for a single patient and across patient groups)
requires the development of an inhalation device that consistently delivers
predictable amounts of dry powder formulations to the deep lung, accurate unit
dose packaging of dry powder formulations and moisture resistant packaging.
There can be no assurance that Inhale will be able to successfully develop such
an inhalation device or overcome such other obstacles to reproducible dosing.

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CLINICAL STATUS SUMMARY

    The following table sets forth, for both Inhale's partner development
programs and Inhale's programs available for partnering, the drug currently in
development, the indication(s) for the particular drug, its present stage of
clinical development and, with respect to Inhale's partner development programs,
the identity of Inhale's corporate partner for such drug.

                          PARTNER DEVELOPMENT PROGRAMS

<TABLE>
<CAPTION>
DRUG                                        INDICATION(S)      CLINICAL STATUS(1)       PARTNER
- ----                                      ------------------   ------------------   ---------------
<S>                                       <C>                  <C>                  <C>
Insulin.................................  Type 1 and 2         Phase III            Pfizer
                                          Diabetes

Alpha-1 Proteinase Inhibitor............  Genetic Emphysema    Phase I              Aventis Behring

AVONEX-Registered Trademark-............  Multiple Sclerosis   Preclinical          Biogen

Undisclosed Protein.....................  Not Released         Preclinical          Lilly

PTH.....................................  Osteoporosis         Phase I              Lilly
</TABLE>

         PROGRAMS AVAILABLE OR EXPECTED TO BE AVAILABLE FOR PARTNERING

<TABLE>
<CAPTION>
DRUG                                                     INDICATION(S)             CLINICAL STATUS(1)
- ----                                            --------------------------------   ------------------
<S>                                             <C>                                <C>
Calcitonin....................................  Osteoporosis, Bone Pain, Paget's   Phase I
                                                Disease

Interleukin-1 Receptor........................  Asthma                             Phase I/II

Undisclosed Non-Protein, Non-Peptide..........  Not Released                       Phase II

Undisclosed Non-Protein, Non-Peptide..........  Not Released                       Phase I

Undisclosed Non-Protein, Non-Peptide..........  Not Released                       Preclinical
</TABLE>

- ------------------------

(1) Clinical Status means:

Phase III - large-scale out-patient clinical trials conducted to obtain
information regarding specific patient groups conducted following encouraging
Phase II trial results.

Phase II - clinical trials to establish dosing and efficacy in patients

Phase I - clinical trials in healthy subjects to test safety, and for drugs with
systemic applications, to test bioavailability compared with injection.

Preclinical - formulation development and animal testing in preparation for
human trials

INHALE'S PARTNER DEVELOPMENT PROGRAMS

    In general, Inhale's partnership arrangements provide funding for
development, payments upon the achievement of certain milestones and royalty and
manufacturing revenues upon the commencement of commercial sales. The
arrangements are cancelable by the partner at any time without significant
penalty.

INSULIN PROGRAM

    Insulin is a protein hormone naturally secreted by the pancreas to induce
the removal of glucose from the blood. Diabetes, the inability of the body to
properly regulate blood glucose levels, is caused by insufficient production of
insulin by the pancreas or insufficient use of the insulin that is secreted.
Over

                                       8
<PAGE>
time, high blood glucose levels can lead to blindness, loss of circulation,
kidney failure, heart disease or stroke. Insulin is currently marketed only in
injectable form. Insulin is supplied by various manufacturers, including Lilly,
Novo-Nordisk A/S and Aventis.

    According to the United States Centers for Disease Control and Prevention,
approximately 16 million people in the United States have diabetes
(10.3 million are diagnosed with diabetes; another 5.4 million have undiagnosed
diabetes) and 798,000 new cases are diagnosed each year. All Type 1 diabetics,
estimated at between 5% and 15% of all diabetics, require insulin therapy. Type
1 diabetics require both a baseline treatment of long-acting insulin and
multiple treatments of regular, or short acting, insulin throughout the day.
Type 2 diabetics, depending on the severity of their case, may or may not
require insulin therapy. Type 2 diabetics who use insulin are best treated with
regular insulin and sometimes require long-acting insulin as well. Because of
the inconvenience and unpleasantness of injections, many Type 2 patients who do
not require insulin to survive, despite the fact that they would benefit from
it, are reluctant to start treatment.

    Regular insulin is generally administered 30 minutes before mealtimes and
generally is given only twice a day. A ten-year study by the National Institutes
of Health ("NIH"), however, demonstrated that the side effects of diabetes could
be significantly reduced by dosing more frequently. The NIH study recommended
dosing regular insulin three to four times per day, a regimen which would more
closely mirror the action of naturally produced insulin in non-diabetics.
Because of the risk of severe hypoglycemia, this course of treatment is not
recommended for children, older adults, people with heart disease or with a
history of frequent severe hypoglycemia. In addition, many patients are
reluctant to increase their number of daily doses because they find injections
unpleasant and inconvenient.

    Pursuant to a collaborative agreement originally entered into in
January 1995, Inhale and Pfizer are developing an inhaled version of regular
insulin that can be administered in one to three blisters per dose using
Inhale's deep lung delivery system. Inhale believes that its delivery system
could provide increased user convenience and result in greater patient
compliance by eliminating some injections for Type 1 and Type 2 patients and all
injections for some Type 2 patients. In addition, Inhale believes that pulmonary
delivery could yield medical advantages by providing a more rapid acting insulin
than most currently marketed injectable products.

    Through its collaboration with Inhale, Pfizer conducted Phase I and Phase
IIa clinical trials which indicated that pulmonary insulin was absorbed
systemically, reduced blood glucose levels and provided the same glycemic
control as injected insulin. In October 1996, Pfizer initiated a multi-site
Phase IIb outpatient trial to include up to 240 diabetes patients, the results
of which were announced in June 1998. In 70 Type 1 diabetics treated with either
inhaled or conventional injected insulin therapy for three months, blood levels
of hemoglobin A1c, the best index of blood glucose control, were statistically
equivalent. Virtually identical results were obtained in a group of Type 2
diabetics. In September 1998, Pfizer released additional Phase IIb data which
indicated that results from 56 to 69 patients in a three-month trial showed that
individuals with Type 2 diabetes can markedly improve their glycemic control
without insulin injections by combining Inhale's pulmonary insulin with oral
diabetes agents.

    In November 1998, Pfizer and Aventis announced that they entered into
worldwide agreements to manufacture insulin and to co-develop and co-promote
inhaleable insulin. Under the terms of the agreement, Pfizer and Aventis agreed
to construct a jointly owned manufacturing plant in Frankfurt, Germany. Until
its completion, Pfizer will provide Inhale with biosynthetic recombinant insulin
for powder processing from Aventis's existing plant. Inhale will continue to
have responsibility for manufacturing powders and supplying devices and will
receive a royalty on inhaleable insulin products marketed jointly by Pfizer and
Aventis. In November 1998, Pfizer held a meeting for 117 Phase III sites of the
inhaleable insulin trials and in June 1999, Pfizer began dosing for the Phase
III clinical trials.

    In January 1995 and October 1996, Pfizer made two $5 million equity
investments in Inhale at a 25% premium to the market price of Inhale stock at
the time of each investment.

                                       9
<PAGE>
ALPHA-1 PROTEINASE INHIBITOR PROGRAM

    In January 1997, Inhale entered into a collaborative agreement with Aventis
Behring to develop a pulmonary formulation of alpha-1 proteinase inhibitor to
treat patients with alpha-1 antitrypsin deficiency, or genetic emphysema.
Alpha-1 proteinase inhibitor is approved in the United States and several
European countries for augmentation treatment of alpha-1 antitrypsin deficiency.
Current treatment is given by systemic intravenous infusion on a weekly basis.
This "replacement therapy" consists of a concentrated form of alpha-1 proteinase
inhibitor derived from human plasma. Under the terms of the collaboration,
Aventis Behring will receive commercialization rights worldwide excluding Japan
and Inhale will receive royalties on product sales, an up-front signing fee and
up to an estimated $15 million in research and development funding and milestone
payments.

    The two companies have completed preclinical work that indicates Inhale's
dry powder formulation of Aventis Behring's alpha-1 proteinase inhibitor has the
potential to significantly improve the efficiency of delivery compared with
current infusion therapy. Inhale believes its pulmonary delivery system could
significantly reduce the amount of drug needed for genetic emphysema therapy
since alpha-1 proteinase inhibitor could be delivered directly to the lung.
Aventis Behring is currently negotiating to secure rights under patents that
have been granted in Europe directed to aerosol formulations for the treatment
of the lung containing serine protease inhibitors, including alpha-1 proteinase
inhibitor. In December 1999, patient dosing began for Phase I clinical trials.

AVONEX-REGISTERED TRADEMARK- PROGRAM

    In February 1999, Inhale entered into a collaborative agreement with Biogen
to develop an inhaleable formulation of Biogen's proprietary Interferon-Beta-1a,
marketed as AVONEX-Registered Trademark-, for the treatment of Multiple
Sclerosis. Multiple Sclerosis is believed to be the most common chronic
neurological condition of young adults in North America and Europe. It is
estimated that over 250,000 people in the United States are currently affected
by Multiple Sclerosis and that approximately 10,000 new cases are diagnosed
annually in the United States. Under the terms of the agreement, Inhale will
receive royalties on product sales, an up-front signing fee, and up to an
estimated $25 million in research and development funding and potential progress
payments. Biogen will provide bulk AVONEX-Registered Trademark- to Inhale for
formulation into a dry powder which is stable at room temperature. Inhale will
manufacture and package the dry powder and supply inhalation devices. Biogen
will be responsible for clinical trials, marketing and commercialization.

PROPRIETARY MOLECULE PROGRAM WITH LILLY

    In January 1998, Lilly and Inhale entered into a collaborative agreement to
develop an inhaleable formulaton for an undisclosed protein product based on
Inhale's deep lung drug delivery system. Under the terms of the agreement,
Inhale will receive funding of up to $20 million in research, development and
milestone payments. Lilly will receive global commercialization rights for the
pulmonary delivery of the products with Inhale receiving royalties on sales of
any marketed products. Inhale will manufacture packaged powders for, and supply
inhalation devices to, Lilly.

PTH PROGRAM

    In January 1997, Inhale entered into a collaborative agreement with Lilly to
develop pulmonary delivery for parathyroid hormone (PTH 1-34) with the target
indication of treatment and prevention of osteoporosis. At this time,
osteoporosis was estimated to affect approximately 25 million Americans, mostly
women. If not prevented or left untreated, osteoporosis can progress painlessly
until a bone breaks. As many as 35,000 people die each year from a cause
associated with hip fractures, primarily due to complications that result from
surgery or from being confined to bed.

    In late 1998, unexpected observations from a long-term test in rats of the
injectable version of this PTH 1-34 led Lilly to suspend further clinical
development of the injectable and pulmonary versions of this

                                       10
<PAGE>
drug pending further analysis. Inhale is maintaining a minimum development
effort in its pulmonary program pending further direction from Lilly. Depending
on the continued evaluations by Lilly, this inhalation program could be
re-initiated, suspended for an extended period, or possibly terminated. Inhale
does not currently believe that this program will be re-initiated by Lilly in
the near future, if at all.

INHALE'S PROGRAMS AVAILABLE OR EXPECTED TO BE AVAILABLE FOR PARTNERING

CALCITONIN PROGRAM

    Inhale is funding a proprietary program to develop a pulmonary formulation
of calcitonin for the treatment of osteoporosis, bone pain and Paget's disease.
Calcitonin is a peptide hormone secreted by the thyroid gland that inhibits bone
resorption and lowers serum calcium. Calcitonin is available in two forms, fish
and human. Calcitonin is administered daily or every other day by injection in
the United States. In the United States, salmon calcitonin is approved for the
treatment of postmenopausal osteoporosis, Paget's disease, hypercalcemia of
cancer and bone pain. Human calcitonin is approved for Paget's disease and bone
pain. Paget's disease is a chronic disorder of the adult skeleton, in which
localized areas of bone become hyperactive and are replaced by a softened and
enlarged bone structure. About 3% of Caucasians in the United States over age 60
have Paget's disease. Hypercalcemia occurs as a result of excessive serum
calcium levels caused by hyperparathyroidism and malignancy. It occurs in
approximately 10-20% of cancer patients.

    In April 1997, Inhale announced the successful completion of Phase I trials
to investigate the tolerability and bioavailability of pulmonary delivery of a
dry powder, aerosolized form of salmon calcitonin as a potential treatment for
osteoporosis, Paget's disease, hypercalcemia and other bone diseases. The
single-dose study conducted in the United Kingdom with a total of 36 fasted
healthy subjects indicated that the drug was systemically absorbed when
delivered by the pulmonary route with Inhale's system. Inhale is continuing work
on this program while it seeks a partner for further clinical development.

INTERLEUKIN-1 RECEPTOR PROGRAM

    Interleukin-1 is a cytokine that helps initiate the inflammatory response to
foreign pathogens and is believed to be a causative factor for asthma. The
interleukin-1 receptor is a molecule which can block the inflammatory action of
Interleukin-1. Inhale collaborated with Immunex to develop a pulmonary
formulation of interleukin-1 receptor as a therapeutic product for asthma.
Initial formulation development and animal toxicology have been completed, and
the two companies successfully completed Phase I/II trials demonstrating
pulmonary delivery. This program is awaiting further work and/or licensing by
Immunex.

MOLECULE PROGRAMS FORMERLY PARTNERED WITH BAXTER

    In March 1996, Inhale entered into a collaborative agreement with Baxter
International Inc. to use Inhale's dry powder pulmonary delivery system as a
technology platform for developing and launching therapeutic products. In
connection with the collaboration, Baxter made a $20 million equity investment
in Inhale at a 25% premium to the market price of Inhale stock at the time of
the investment. At that time, Baxter received worldwide commercialization rights
for four non-protein/peptide drugs in exchange for up to an estimated
$60 million in research and development funding and progress payments.

    In April 1998, Inhale announced that the first two compounds from its
collaboration with Baxter had successfully completed Phase I and Phase II trials
respectively. In addition, it was announced that the program would focus on the
product that had completed Phase I as it was the product with the most
commercial potential. The technology from one of the three remaining products
was returned to Inhale, leaving the development of the other two compounds on
hold. In October 1998, Inhale announced that it had reached an agreement with
Baxter to amend their collaborative agreement to facilitate signing a new
corporate partner to fund further development and commercialization of the
undisclosed compound that

                                       11
<PAGE>
had been their focus since April 1998. Baxter's obligations under that amendment
expired in September 1999. As a result, rights to the compounds reverted to
Inhale and are now available for other partnering opportunities.

OTHER PROGRAMS

    In addition to the above mentioned programs, Inhale has conducted and
continues to conduct feasibility studies with respect to additional drug
formulations both for its own account and in cooperation with potential
partners. Inhale will continue to pursue these and other feasibility programs to
determine the potential for collaborative development programs with respect to
these drugs. Included among such studies is initial research on a long-acting
inhaleable insulin. Some diabetic patients require a long-acting insulin to
maintain baseline insulin levels. A long-acting, inhaleable form of insulin
could be used by these patients as a supplement to short-acting, mealtime
inhaleable insulin. This program is part of a broader sustained release program
announced by Inhale in January 1999.

MANUFACTURING

    Inhale generally plans to formulate, manufacture and package the powders for
its deep lung delivery products and to subcontract the manufacture of its
proprietary pulmonary delivery devices. Under its collaborative agreement with
Pfizer to develop inhaleable insulin, Inhale will manufacture insulin powders
and Pfizer will be primarily responsible for filling blisters. The terms of the
collaborative agreement with Pfizer provide that prior to the commercialization
of its first products, Inhale must build and have validated a powder processing
facility and must have validated a device manufacturer or manufacturers. Inhale
believes its manufacturing strategy will enable it to achieve the following:

    - provide economies of scale by utilizing manufacturing capacity for
      multiple products;

    - improve its ability to retain any manufacturing know-how; and

    - allow its customers to bring pulmonary delivery products to market faster.

    Inhale has built a powder manufacturing and packaging facility in San
Carlos, California capable of producing powders in quantities sufficient for
clinical trial. This facility has been inspected and licensed by the State of
California and is used to manufacture and package powders under current good
manufacturing practices. Inhale is expanding its facility to meet its future
commercial manufacturing commitments.

    Inhale is working to further scale-up its powder processing to a larger
production scale system and to further develop the necessary powder packaging
technologies. Fine particle powders and small quantity packaging (such as those
to be used in Inhale's delivery system) require special handling. Current
commercial packaging systems are designed for filling larger quantities of
larger particle powders and therefore must be modified to dispense finer
particles in the small quantities required by Inhale. Inhale has developed and
validated a proprietary prototype automated filling system which Inhale believes
is capable of supporting its requirements through Phase III trials and into
commercial production for some products. Inhale is developing a higher capacity
automated filling unit capable of filling blisters on a production scale for
moderate and large volume products. Inhale faces significant technical
challenges in developing an automated, commercial-scale filling system that can
accurately and economically handle the small dose and particle sizes of its
powders. There can be no assurance that Inhale will be able to develop or
acquire the technology necessary to develop successfully any such system in a
timely manner or at commercially reasonable cost. Any failure or delay in
developing such technology would delay product development or bar
commercialization of Inhale's products and would have a material adverse effect
on Inhale.

    Inhale's proprietary inhalation device has been developed for commercial use
and is being used in the Phase III insulin and other trials in 2000. Inhale
plans to subcontract the manufacture of its pulmonary delivery device before
commercial production of its first product. Inhale has identified contract
manufacturers that it believes have the technical capabilities and production
capacity to manufacture its devices

                                       12
<PAGE>
and which can meet the requirements of current good manufacturing practices.
There can be no assurance that Inhale will be able to obtain and maintain
satisfactory contract manufacturing on commercially acceptable terms, if at all.
Inhale's dependence upon third parties for the manufacture of its inhalation
device may adversely affect Inhale's cost of goods and its ability to develop
and commercialize products on a timely and competitive basis.

GOVERNMENT REGULATION

    The research and development, manufacture and marketing of pulmonary drug
delivery systems are subject to regulation by the FDA in the United States and
by comparable regulatory agencies in other countries. These national agencies
and other federal, state and local entities regulate, among other things,
research and development activities and the testing, manufacture, safety,
effectiveness, labeling, storage, record keeping, approval, advertising and
promotion of Inhale's products.

    The process required by the FDA before a pulmonary drug delivery system may
be marketed in the United States depends on whether the compound has existing
approval for use in other dosage forms. If the drug is a new chemical entity
that has not been approved, the process includes the following:

    - extensive preclinical laboratory and animal testing;

    - submission of an Investigational New Drug application ("IND");

    - adequate and well-controlled human clinical trials to establish the safety
      and efficacy of the drug for the intended indication: and

    - submission to the FDA for approval of a New Drug Application ("NDA") with
      respect to drugs or a Biological License Application ("BLA") with respect
      to biologics.

    If the drug has been previously approved, the approval process is similar,
except that certain preclinical tests relating to systemic toxicity normally
required for the IND and NDA/BLA application may not be necessary.

    Preclinical tests include laboratory evaluation of product chemistry and
animal studies to assess the potential safety and efficacy of the product and
its formulation. Pulmonary drug products must be formulated according to current
good manufacturing practices, and pre-clinical safety tests must be conducted by
laboratories that comply with FDA good laboratory practices regulations. The
results of the pre-clinical tests are submitted to the FDA as part of an IND
application and are reviewed by the FDA before clinical trials begin. Clinical
trials may begin 30 days after receipt of the IND by the FDA, unless the FDA
raises objections during that period.

    Clinical trials involve the administration of the drug to healthy volunteers
or to patients under the supervision of a qualified medical investigator.
Clinical trials are conducted in accordance with protocols that detail the
objectives of the study, the parameters to be used to monitor participant safety
and efficacy or other criteria to be evaluated. Each protocol is submitted to
the FDA as part of the IND. Each clinical study is conducted under the auspices
of an independent Institutional Review Board ("IRB"). The IRB will consider,
among other things, ethical factors, the potential risks to subjects
participating in the trial and the possible liability of the institution.

    Clinical trials are typically conducted in three sequential phases, but the
phases may overlap. In Phase I, the initial introduction of the drug into
healthy human subjects, the product generally is tested for tolerability,
pharmacokinetics, absorption, metabolism and excretion. Phase II involves
studies in a limited patient population to:

    - determine the efficacy of the product for specific targeted indications;

    - determine dosage tolerance and optimal dosage; and

    - identify possible adverse effects and safety risks.

                                       13
<PAGE>
    After Phase II trials demonstrate that administration of the drug by the
pulmonary route is effective and has an acceptable safety profile, Phase III
trials are undertaken to evaluate further clinical efficacy and safety within an
expanded patient population at geographically dispersed clinical study sites.
The FDA, the clinical trial sponsor, the investigators or the IRB may suspend
clinical trials at any time if any one of them believe that study participants
are being exposed to an unacceptable health risk.

    The results of product development, pre-clinical studies and clinical
studies are submitted to the FDA as an NDA/BLA for approval of the marketing and
commercial shipment of the pulmonary drug product. The FDA may deny an NDA/BLA
if applicable regulatory criteria are not satisfied or may require additional
clinical testing. Even if such data are submitted, the FDA may ultimately decide
that the NDA/BLA does not satisfy the criteria for approval. Product approvals
may be withdrawn if compliance with regulatory standards are not maintained or
if safety concerns arise after the product reaches the market. The FDA may
require post marketing testing and surveillance programs to monitor the effect
of pulmonary drug products that have been commercialized, and has the power to
prevent or limit future marketing of the product based on the results of such
programs.

    Each domestic drug product manufacturing establishment must be registered
with, and approved by, the FDA. Drug product manufacturing establishments
located in California also must be licensed by the State of California.
Establishments handling controlled substances must be licensed by the United
States Drug Enforcement Administration ("DEA"). Domestic manufacturing
establishments are subject to biennial inspections by the FDA for compliance
with current good manufacturing practices compliance. Inhale is also subject to
U.S. federal, state and local regulations regarding workplace safety,
environmental protection and hazardous and controlled substance controls, among
others.

    Many of the drugs with which Inhale is working are already approved for
marketing by the FDA. Inhale believes that when working with approved drugs, the
approval process for delivery by pulmonary drug products may require less time
and fewer tests than for new chemical entities. However, Inhale expects that its
formulations often will use excipients not currently approved for pulmonary use.
Use of these excipients will require additional toxicological testing that may
increase the costs of, or lengthen the time in, gaining regulatory approval. In
addition, regulatory procedures applicable to Inhale's products may change as
regulators gain experience in the area of macromolecules, and any such changes
may delay or increase the cost of regulatory approval.

    For the products currently under development, Inhale's device is considered
to be part of a drug/ device combination for deep lung delivery of each specific
molecule. Prior to submission of an IND, the FDA Center and division within the
FDA Center responsible for the review of the IND and NDA/BLA will be identified.
In the case of Inhale's products, either the Center for Drug Evaluation and
Research or the Center for Biologics Evaluation and Research, in consultation
with the Center for Devices and Radiological Health, could be involved in the
review. However, one Center is designated as the Center which has the lead
responsibility for regulating the product. The jurisdiction within the FDA is
based on the primary mode of action of the drug and is identified in the FDA's
intercenter agreement.

    Inhale expects that its partners generally will be responsible for clinical
and regulatory approval procedures, but Inhale may participate in this process
by submitting to the FDA a drug master file developed and maintained by Inhale
which contains data concerning the manufacturing processes for the product. The
clinical and manufacuturing development and regulatory review process generally
takes a number of years and requires the expenditure of substantial resources.
Inhale's ability to manufacture and sell products developed under contract
depends upon the partner's completion of satisfactory clinical trials and
obtaining marketing approvals. Inhale may prepare and submit an IND application
and perform initial clinical studies before licensing the product to a partner.
Inhale's business strategy contemplates performing more of these studies in the
future.

                                       14
<PAGE>
    Sales of Inhale's products outside the United States are subject to local
regulatory requirements governing clinical trials and marketing approval for
drugs and pulmonary delivery systems. Such requirements vary widely from country
to country.

    Prior to marketing a new dosage form of any drug, including one developed
for use with Inhale's pulmonary drug delivery system, the product must undergo
rigorous preclinical and clinical testing and an extensive review process
mandated by the FDA and equivalent foreign authorities regardless of whether or
not such drug was already approved for marketing in another dosage form. These
processes generally take a number of years and require the expenditure of
substantial resources. None of Inhale's proposed products has been submitted to
the FDA for marketing approval. Inhale has no experience obtaining such
regulatory approval, does not have the expertise or other resources to do so and
intends to rely on its partners to fund clinical testing and to obtain product
approvals.

PATENTS AND PROPRIETARY RIGHTS

    Inhale's policy is to apply for patent protection for the technology,
inventions and improvements deemed important to the development of its business.
Inhale also relies upon trade secrets, know-how, continuing technological
innovations and licensing opportunities to maintain and further develop its
competitive position. Inhale plans to defend aggressively its proprietary
technology and any issued patents.

    Inhale expects that its integrated system for pulmonary delivery of both
large and small molecule drugs will yield innovations in dry powder
formulations, powder processing, powder packaging and device design. It is
Inhale's strategy to build proprietary positions in each of its technological
areas. Inhale's success will depend in part upon its ability to protect its
proprietary technology from infringement, misappropriation, duplication and
discovery. Inhale has filed patent applications covering certain aspects of its
device and powder processing technology and powder formulations and pulmonary
route of delivery for certain molecules, and plans to file additional patent
applications. There can be no assurance that any of the patents applied for by
Inhale will issue, or that any patents that issue will be valid and enforceable.
Even if such patents are enforceable, Inhale anticipates that any attempt to
enforce its patents could be time consuming and costly.

    Inhale currently has 49 issued U.S. and foreign patents covering certain
aspects of its technology and has a number of patent applications pending. The
United States Patent and Trademark Office (the "PTO") has issued the following
patents to Inhale:

    - Patent No. 5,458,135 (October 17, 1995) for certain claims covering the
      use of its device in a method for delivering aerosolized (including
      powder) formulations of drugs to the lung.

    - Patent No. 5,607,915 (March 4, 1997) for pulmonary delivery of active
      fragments of parathyroid hormone (PTH) 1-34.

    - Patent No. 5,654,007 (August 5, 1997) for a system and methods for
      processing fine dispersible powders for easier processing.

    - Patent No. 5,740,794 (April 21, 1998) for a method and means to access a
      packaged drug, to break up a dry powder drug into particles with
      compressed air (aerosolize), and to transport the aerosolized drug into a
      holding chamber.

    - Patent No. 5,775,320 (July 7, 1998) for a method and means for dispersing
      a dry-powder or liquid drug, and transferring the drug in its aerosolized
      "cloud" form to a holding chamber where it is held until a patient is
      ready to inhale, as well as a method and means to pull in atmospheric
      "chase" air following the initial inhalation to help push the drug into
      the deep lung.

    - Patent No. 5,780,014 (July 14, 1998) for methods and means for pulmonary
      delivery of dry powder alpha1-antitrypsin, a proteinase inhibitor, for
      administration to a patient.

                                       15
<PAGE>
    - Patent No. 5,785,049 (July 28, 1998) for approximately 50 claims directed
      to methods and means for aerosolizing dry powders through use of a high
      pressure gas stream to draw dry powder from a receptacle such as a blister
      pack and for which Inhale utilizes the design described therein to achieve
      efficient aerosolization of fine dry powders to enable deep lung delivery
      for systemic absorption.

    - Patent No. 5,814,607 (September 29, 1998) for pulmonary delivery of active
      fragments of parathyroid hormone of between 34 and 38 amino acids in
      length.

    - Patent No. 5,826,633 (October 27, 1998) relating to Inhale's powder
      handling technologies, including the process of transferring fine powder
      particles into blister packs in an un-compacted state so that they can be
      easily dispersed in Inhale's pulmonary delivery system.

    - Patent No. 5,922,354 (July 13, 1999) for a method for preparing fine
      particles by agglomeration.

    - Patent No. 5,928,469 (July 27, 1999) for a method for preparing storage
      stable compositions. In this method, a material to be stored and a glass
      forming substance are spray-dried to form stable particles.

    - Patent No. 5,976,574 (November 2, 1999) for a process for spray-drying
      hydrophobic drugs in organic solvent suspensions.

    - Patent No. 5,985,248 (November 16, 1999) for a process for spray-drying a
      hydrophobic drug and a hydrophilic excipient in an organic solvent and
      compositions formed by the process.

    - Patent No. 5,993,783 (November 30, 1999) for a respirable
      alpha-1-antitrypsin dry powder having an areodynamic diameter of less than
      5 Microns.

    - Patent No. 5,994,314 (November 30, 1999) for dry powder nucleic acid
      compositions and methods for their preparation.

    - Patent No. 5,997,848 (December 7, 1999) for pulmonary administration of
      dry powder insulin which is rapidly absorbed through the alveoli into the
      systemic circulation.

    - Patent No. 6,001,336 (December 14, 1999) for a process for spray drying a
      hydrophobic drug in an aqueous suspension with a hydrophilic component.

    In November, 1999, Inhale acquired from Alliance Pharmaceutical Corp. its
PulmoSpheres-Registered Trademark- technology and other related assets for
particle formulation and powder processing, subject to the terms and conditions
of an asset purchase agreement. The PulmoSpheres-Registered Trademark-
technology utilizes an emulsification process to produce a powder having
characteristics that Inhale believes may improve efficiency and reproducibility
for drugs delivered to the lung through alternative technologies such as MDIs as
well as potentially improve drug delivery through Inhale's proprietary deep lung
drug delivery system. The assets acquired included Alliance's intellectual
property portfolio for PulmoSpheres-Registered Trademark- consisting of, among
other things, several patent applications. With respect to applications of the
PulmoSpheres-Registered Trademark- technology outside the respiratory field,
Inhale has licensed the technology back to Alliance. While Alliance has made
several representations in its agreement with Inhale regarding its ownership
rights of the PulmoSpheres-Registered Trademark- technology, it is possible that
third parties might assert claims challenging Alliance's rights, and thus
Inhale's rights. Even if Inhale can defend its rights successfully, the
uncertainty regarding the status of its rights during the time any such
litigation is pending may prevent Inhale from using the underlying technology.

    In March 1998, Inhale and Initiatech Inc. signed an agreement under which
Inhale licensed technology, intellectual property, and patents for protecting
biologically active compounds in the dry state. Inhale intends to use this
technology to expand its current technology base in stabilizing dry powder
aerosol formulations for peptides, proteins, and other macromolecules at room
temperature. Inhale's license is exclusive for the fields of respiratory
delivery of pharmaceutical products and for any delivery form of insulin. The
license includes rights to two issued U.S. patents and a Canadian patent
covering the

                                       16
<PAGE>
protection of biological materials from degradation in the dry state. Initiatech
has licensed exclusive rights to this technology from the Boyce Thompson
Institute for Plant Research, Inc.

    In June 1997, Inhale acquired the intellectual property portfolio of the
BioPreservation Division of Pafra. This portfolio includes issued U.S. and
foreign Letters Patent and pending applications relating to the stabilization of
macromolecule drugs in dry formulations. An application for reissue of the
original U.S. patent included in this portfolio is pending in the PTO. There can
be no assurance that Inhale will be successful in obtaining a reissued patent. A
second U.S. patent from this portfolio issued to Inhale on July 27, 1999 and is
noted above. A granted European patent included in this portfolio was the
subject of an opposition proceeding before the European Patent Office. The
opposition hearing was held on December 16, 1999. Inhale successfully defended
the patent and its method claims relating to glass stabilization technology
against four opposing parties. In addition, in late 1999, based on claims of
this granted European patent, Inhale filed an infringement action in the courts
of the United Kingdom against Quadrant Healthcare plc. There can be no assurance
that any of the other Pafra patent applications will be held to be valid and
enforceable. The inability to obtain or defend the Pafra patents could have a
material adverse effect on Inhale.

    Inhale has obtained license rights to certain know-how and patent
applications owned by Genentech, Inc. covering formulations, powder processing
and pulmonary delivery of certain molecules, which it believes could be
important to the development of its business. These license rights are
worldwide, nonexclusive, sublicensable and royalty free. In 1997, Genentech
successfully defended an opposition proceeding involving a pending European
patent licensed to Inhale. Recently, this decision was upheld on appeal. The
pending patent covers the pulmonary delivery of cytokines and growth factors.

    The patent positions of pharmaceutical, biotechnology and drug delivery
companies, including Inhale, are uncertain and involve complex legal and factual
issues. Additionally, the coverage claimed in a patent application can be
significantly reduced before the patent is issued. As a consequence, Inhale does
not know whether any of its patent applications will be granted with broad
coverage or whether the claims that eventually issue will be circumvented. Since
patent applications in the United States are maintained in secrecy until patents
issue, and since publication of discoveries in scientific or patent literature
often lag behind actual discoveries, Inhale cannot be certain that it was the
first inventor of inventions covered by its issued patents or pending patent
applications or that it was the first to file patent applications for such
inventions. Moreover, Inhale may have to participate in interference proceedings
declared by the PTO to determine priority of invention, which could result in
substantial cost to Inhale, even if the eventual outcome is favorable. An
adverse outcome could subject Inhale to significant liabilities to third
parties, require disputed rights to be licensed from or to third parties or
require Inhale to cease using the technology in dispute.

    Inhale is aware of numerous pending and issued U.S. and foreign patent
rights and other proprietary rights owned by third parties that relate to
aerosol devices and delivery, pharmaceutical formulations, dry powder processing
technology and the pulmonary route of delivery for certain powder formulations
of macromolecules. Inhale cannot predict with any certainty which, if any,
patent references will be considered relevant to its technology by authorities
in the various jurisdictions where such rights exist, nor can Inhale predict
with certainty which, if any, of these rights will or may be asserted against it
by such third parties. There can be no assurance that Inhale can obtain any
license to any technology that it determines it needs, on reasonable terms, if
at all, or that Inhale could develop or otherwise obtain alternate technology.
The failure to obtain licenses if needed would have a material adverse effect on
Inhale.

    Inhale also relies upon trade secret protection for its confidential and
proprietary information. No assurance can be given that others will not
independently develop substantially equivalent proprietary information and
techniques or otherwise gain access to Inhale's trade secrets or disclose such
technology, or that Inhale can meaningfully protect its trade secrets.

                                       17
<PAGE>
    Third parties from time to time have asserted or may assert that Inhale is
infringing their proprietary rights based upon issued patents, trade secrets or
know-how that they believe cover Inhale's technology. In addition, future
patents may issue to third parties which Inhale's technology may infringe.
Inhale could incur substantial costs in defending itself and its partners
against any such claims. Furthermore, parties making such claims may be able to
obtain injunctive or other equitable relief which could effectively block
Inhale's ability to further develop or commercialize some or all of its products
in the United States and abroad, and could result in the award of substantial
damages. In the event of a claim of infringement, Inhale and its partners may be
required to obtain one or more licenses from third parties. There can be no
assurance that Inhale or its partners will be able to obtain such licenses at a
reasonable cost, if at all. Defense of any lawsuit or failure to obtain any such
required license could have a material adverse effect on Inhale.

    Inhale's ability to develop and commercialize its technology will be
affected by its or its partners' access to the drugs which are to be formulated.
Many biopharmaceutical drugs, including some of those which are presently under
development by Inhale, are subject to issued and pending United States and
foreign patent rights which may be owned by competing entities. There are issued
patents and pending patent applications relating to the pulmonary delivery of
macromolecule drugs, including several for which Inhale is developing pulmonary
delivery formulations. Inhale intends generally to rely on the ability of its
partners to provide access to the drugs which are to be formulated for pulmonary
delivery. There can be no assurance, however, that Inhale's partners will be
able to provide access to drug candidates for formulation for pulmonary delivery
or that, if such access is provided, Inhale or its partners will not be accused
of, or determined to be, infringing a third party's rights and will not be
prohibited from working with the drug or be found liable for damages that may
not be subject to indemnification. Any such restriction on access or liability
for damages would have a material adverse effect on Inhale.

    It is Inhale's policy to require its employees and consultants, outside
scientific collaborators, sponsored researchers and other advisors who receive
confidential information from Inhale to execute confidentiality agreements upon
the commencement of employment or consulting relationships with Inhale. These
agreements provide that all confidential information developed or made known to
the individual during the course of the individual's relationship with Inhale is
to be kept confidential and not disclosed to third parties except in specific
circumstances. The agreements provide that all inventions conceived by an
employee shall be the property of Inhale. There can be no assurance, however,
that these agreements will provide meaningful protection or adequate remedies
for Inhale's trade secrets in the event of unauthorized use or disclosure of
such information.

COMPETITION

    Inhale believes that products developed using its technology will compete on
the basis of system efficiency, dosage reproducibility, safety, patient
convenience and cost. There is intense competition to develop a solution to the
non-invasive delivery of drugs from several drug delivery and pharmaceutical
companies, many of which are much larger and have far greater resources than
Inhale. These include companies working on developing systems for other
non-invasive routes of delivery, such as oral, transdermal, bucal, nasal, and
needle-less injections, as well as companies working on pulmonary delivery
systems. In addition, several companies are working on sustained release
injectable systems. While these latter systems involve injections, the lower
number of injections could be competitive with Inhale's pulmonary delivery
technology in certain applications. Inhale believes its technology and
integrated pulmonary delivery systems approach provides it with important
competitive advantages in the delivery of drugs compared with currently known
alternatives. However, new drugs or further developments in alternative drug
delivery methods may provide greater therapeutic benefits for a specific drug or
indication, or may offer comparable performance at lower cost than Inhale's
proprietary deep lung drug delivery system.

                                       18
<PAGE>
    With respect to pulmonary delivery, several companies are marketing and
developing dry powder, MDI, liquid and nebulizer devices that could have
applications for drug delivery, including Dura Pharmaceuticals, Inc. and Aradigm
Corporation, which also have collaborative arrangements with corporate partners
for the development of pulmonary delivery systems for insulin. Several of these
companies may have or may be developing dry powder devices that could be used
for pulmonary delivery of proteins and other macromolecules. There can be no
assurance that competitors will not introduce products or processes competitive
with or superior to those of Inhale. Inhale intends to monitor competitive
device activities and continue to focus its activities on those products for
which Inhale believes it has and can maintain a competitive advantage. If a
device is developed that is superior to Inhale's for certain applications,
Inhale may seek to obtain a license to allow Inhale's partners to use such
device with Inhale-developed powders, although there can be no assurance that
Inhale would be able to do so.

    Inhale's success depends upon maintaining a competitive advantage in the
development of products and technologies for pulmonary delivery of
pharmaceutical drugs. If a competing company were to develop or acquire rights
to a better system for efficiently and reproducibly delivering macromolecule
drugs to the deep lung, a non-invasive drug delivery system which is more
attractive for delivery drugs to the deep lung, a non-invasive delivery system
which is more attractive for the delivering of drugs than pulmonary delivery, or
an invasive delivery system which overcomes some of the drawbacks of current
invasive systems for chronic or subtonic indications (such as sustained release
systems), Inhale's business would be negatively impacted.

    Inhale is in competition with pharmaceutical, biotechnology and drug
delivery companies, hospitals, research organizations, individual scientists and
nonprofit organizations engaged in the development of alternative drug delivery
systems or new drug research and testing, as well as with entities producing and
developing injectable drugs. Inhale is aware of a number of companies currently
seeking to develop new products and non-invasive alternatives to injectable drug
delivery, including oral delivery systems, intranasal delivery systems,
transdermal systems, bucal and colonic absorption systems. Several of these
companies may have developed or are developing dry powder devices that could be
used for pulmonary delivery of macromolecules. Many of these companies and
entities have greater research and development capabilities, experience,
manufacturing, marketing, financial and managerial resources than Inhale and
represent significant competition for Inhale. Acquisitions of competing drug
delivery companies by large pharmaceutical companies could enhance competitors'
financial, marketing and other resources. Accordingly, Inhale's competitors may
succeed in developing competing technologies, obtaining FDA approval for
products or gaining market acceptance more rapidly than Inhale. Developments by
others may render Inhale's products or technologies noncompetitive or obsolete.

EMPLOYEES AND CONSULTANTS

    As of December 31, 1999, Inhale had 339 employees, of which 252 were engaged
in research and development (including manufacturing) activities and 87 in
general administration and business development. One hundred twenty-five of the
employees hold advanced degrees, of which 88 are Ph.D.s. Inhale employs
scientists and engineers with expertise in the areas of pulmonary biology,
aerosol science, powder technology, mechanical engineering, protein chemistry
and chemical engineering. None of Inhale's employees are covered by a collective
bargaining agreement and Inhale has experienced no work stoppages. Inhale
believes that it maintains good relations with its employees.

    To complement its own expertise, Inhale utilizes specialists in regulatory
affairs, pulmonary toxicology, process engineering, manufacturing, quality
assurance, device design, clinical trial design and business development. These
individuals include certain of Inhale's scientific advisors as well as
independent consultants. See "Management."

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<PAGE>
RISK FACTORS

    THE FOLLOWING RISK FACTORS SHOULD BE READ CAREFULLY IN CONNECTION WITH
EVALUATING INHALE'S BUSINESS. ANY OF THE FOLLOWING RISKS COULD MATERIALLY
ADVERSELY AFFECT INHALE'S BUSINESS AND OPERATING RESULTS OR FINANCIAL CONDITION.

WE DO NOT KNOW IF OUR DEEP LUNG DRUG DELIVERY SYSTEM IS COMMERCIALLY FEASIBLE.

    We are in an early stage of development. There is a risk that our deep lung
drug delivery technology will not be commercially feasible. Even if our deep
lung delivery technology is commercially feasible, it may not be commercially
accepted across a range of large and small molecule drugs. We have tested seven
deep lung delivery formulations in humans, but many of our potential
formulations have not been tested in humans.

    Many of the underlying drug compounds contained in our deep lung
formulations have been tested in humans by other companies using alternative
delivery routes. Our potential products require extensive research, development
and pre-clinical (animal) and clinical (human) testing. Our potential products
also may involve lengthy regulatory review before they can be sold. We do not
know if and cannot assure you that, any of our potential products will prove to
be safe and effective or meet regulatory standards. There is a risk that any of
our potential products will not be able to be produced in commercial quantities
at acceptable cost or marketed successfully. Our failure to achieve commercial
feasibility, demonstrate safety, achieve clinical efficacy, obtain regulatory
approval or, together with partners, successfully market products will
negatively impact our revenues and results of operations.

WE DO NOT KNOW IF OUR DEEP LUNG DRUG DELIVERY SYSTEM IS EFFICIENT.

    We may not be able to achieve the total system efficiency needed to be
competitive with alternative routes of delivery. Total system efficiency is
determined by the amount of drug loss during manufacture, in the delivery
device, in reaching the site of absorption, and during absorption from that site
into the bloodstream. Deep lung bioavailability is the percentage of a drug that
is absorbed into the bloodstream when that drug is delivered directly to the
lungs as compared to when the drug is delivered by injection. Bioavailability is
the initial screen for whether deep lung delivery of any systemic drug is
commercially feasible. We would not consider a drug to be a good candidate for
development and commercialization if its drug loss is excessive at any one stage
or cumulatively in the manufacturing and delivery process or if its deep lung
bioavailability is too low.

WE DO NOT KNOW IF OUR DEEP LUNG DRUG FORMULATIONS ARE STABLE.

    We may not be able to identify and produce powdered versions of drugs that
retain the physical and chemical properties needed to work with our delivery
device. Formulation stability is the physical and chemical stability of the drug
over time and under various storage, shipping and usage conditions. Formulation
stability will vary with each deep lung formulation and the type and amount of
ingredients that are used in the formulation. Problems with powdered drug
stability would negatively impact our ability to develop and market our
potential products or obtain regulatory approval.

WE DO NOT KNOW IF OUR DEEP LUNG DRUG DELIVERY SYSTEM IS SAFE.

    We may not be able to prove potential products to be safe. Our products
require lengthy laboratory, animal and human testing. Most of our products are
in preclinical testing or the early stage of human testing. If we find that any
product is not safe, we will not be able to commercialize the product. The
safety of our deep lung formulations will vary with each drug and the
ingredients used in its formulation.

                                       20
<PAGE>
WE DO NOT KNOW IF OUR DEEP LUNG DRUG DELIVERY SYSTEM PROVIDES CONSISTENT DOSES
  OF MEDICINE.

    We may not be able to provide reproducible dosages of stable formulations
sufficient to achieve clinical success. Reproducible dosing is the ability to
deliver a consistent and predictable amount of drug into the bloodstream over
time both for a single patient and across patient groups. Reproducible dosing
requires the development of:

    - an inhalation device that consistently delivers predictable amounts of dry
      powder formulations to the deep lung;

    - accurate unit dose packaging of dry powder formulations; and

    - moisture resistant packaging.

    We may not be able to develop reproducible dosing of any potential product.
The failure to do so means that we would not consider it a good candidate for
development and commercialization.

WE DEPEND ON PARTNERS FOR REGULATORY APPROVALS AND COMMERCIALIZATION OF OUR
  PRODUCTS.

    Because we are in the business of developing technology for delivering drugs
to the lungs and licensing this technology to companies that make and sell
drugs, we do not have the people and other resources to do the following things:

    - make bulk drugs to be used as medicines;

    - design and carry out large scale clinical studies;

    - prepare and file documents necessary to obtain government approval to sell
      a given drug product; and

    - market and sell our products when and if they are approved.

    When we sign a collaborative development agreement or license agreement to
develop a product with a drug company, the drug company agrees to do some or all
of the things described above. If our partner fails to do any of these things,
we cannot complete the development of the product.

WE MAY NOT OBTAIN REGULATORY APPROVAL FOR OUR PRODUCTS ON A TIMELY BASIS, OR AT
  ALL.

    There is a risk that we will not obtain regulatory approval for our products
on a timely basis, or at all. Our product must undergo rigorous animal and human
testing and an extensive review process mandated by the United States Food and
Drug Administration ("FDA") and equivalent foreign authorities. This process
generally takes a number of years and requires the expenditure of substantial
resources; although the time required for completing such testing and obtaining
such approvals is uncertain. We have not submitted any of our products to the
FDA for marketing approval. We have no experience obtaining such regulatory
approval.

    In addition, we may encounter delays or rejections based upon changes in FDA
policy, including policy relating to good manufacturing practice compliance,
during the period of product development. We may encounter similar delays in
other countries.

    Even if regulatory approval of a product is granted, the approval may limit
the indicated uses for which we may market our product. In addition, our
marketed product, our manufacturing facilities and Inhale, as the manufacturer,
will be subject to continual review and periodic inspections. Later discovery
from such review and inspection of previously unknown problems may result in
restrictions on our product or on us, including withdrawal of our product from
the market. The failure to obtain timely regulatory approval of our products,
any product marketing limitations or a product withdrawal would negatively
impact our revenues and results of operations.

                                       21
<PAGE>
WE DO NOT KNOW IF OUR TECHNOLOGIES CAN BE INTEGRATED SUCCESSFULLY TO BRING
  PRODUCTS TO MARKET.

    We may not be able to integrate all of the relevant technologies to provide
a deep lung drug delivery system. Our integrated approach to systems development
relies upon several different but related technologies:

    - dry powder formulations;

    - dry powder processing technology;

    - dry powder packaging technology; and

    - deep lung delivery devices.

    At the same time we must:

    - establish collaborations with partners;

    - perform laboratory and clinical testing of potential products; and

    - scale-up our manufacturing processes.

    We must accomplish all of these steps without delaying any aspect of
technology development. Any delay in one component of product or business
development could delay our ability to develop, obtain approval of or market
therapeutic products using our deep lung delivery technology.

WE MAY NOT BE ABLE TO MANUFACTURE OUR PRODUCTS IN COMMERCIAL QUANTITIES.

    POWDER PROCESSING.  We have no experience manufacturing products for
commercial purposes. We have only performed powder processing on the small scale
needed for testing formulations and for early stage and larger clinical trials.
We may encounter manufacturing and control problems as we attempt to scale-up
powder processing facilities. We may not be able to achieve such scale-up in a
timely manner or at a commercially reasonable cost, if at all. Our failure to
solve any of these problems could delay or prevent late stage clinical testing
and commercialization of our products and could negatively impact our revenues
and results of operations.

    To date, we have relied on one particular method of powder processing. There
is a risk that this technology will not work with all drugs or that the cost of
drug production will preclude the commercial viability of certain drugs.
Additionally, there is a risk that any alternative powder processing methods we
may pursue will not be commercially practical for aerosol drugs or that we will
not have, or be able to acquire the rights to use, such alternative methods.

    POWDER PACKAGING.  Our fine particle powders and small quantity packaging
require special handling. We have designed and qualified automated filling
equipment for small and moderate quantity packaging of fine powders. We face
significant technical challenges in scaling-up an automated filling system that
can handle the small dose and particle sizes of our powders in commercial
quantities. There is a risk that we will not be able to scale-up our automated
filling equipment in a timely manner or at commercially reasonable costs. Any
failure or delay in such scale-up would delay product development or bar
commercialization of our products and would negatively impact our revenues and
results of operations.

    INHALATION DEVICE.  We face many technical challenges in further developing
our inhalation device to work with a broad range of drugs, to produce such a
device in sufficient quantities and to adapt the device to different powder
formulations. In addition, we are attempting to develop a smaller inhalation
device, which presents particular technical challenges. There is a risk that we
will not successfully achieve any of these challenges. Our failure to overcome
any of these challenges would negatively impact our revenues and results of
operations.

                                       22
<PAGE>
    For late stage clinical trials and initial commercial production, we intend
to use one or more contract manufacturers to produce our drug delivery device.
There is a risk that we will not be able to enter into or maintain arrangements
with any potential contract manufacturers or effectively scale-up production of
our drug delivery devices through contract manufacturers. Our failure to do so
would negatively impact our revenues and results of operations.

WE DEPEND ON SOLE OR EXCLUSIVE SUPPLIERS FOR OUR INHALATION DEVICE AND BULK
  DRUGS.

    We plan to subcontract the manufacture of our pulmonary delivery device
before commercial production of our first product. We have identified contract
manufacturers that we believe have the technical capabilities and production
capacity to manufacture our devices and which can meet the requirements of good
manufacturing practices. We cannot be assured that we will be able to obtain and
maintain satisfactory contract manufacturing on commercially acceptable terms,
if at all. Our dependence on third parties for the manufacture of our inhalation
device may negatively impact our cost of goods and our ability to develop and
commercialize products on a timely and competitive basis.

    We obtain the bulk drugs we use to formulate and manufacture the dry powders
for our deep lung delivery system from sole or exclusive sources of supply. For
example, with respect to our source of bulk insulin, we have entered into a
collaborative agreement with Pfizer which has, in turn, entered into an
agreement with Aventis to manufacture biosynthetic recombinant insulin. Under
the terms of their agreement, Pfizer and Aventis agreed to construct a jointly
owned manufacturing plant in Frankfurt, Germany. Until its completion, Pfizer
will provide us with insulin from Aventis's existing plant. If our sole or
exclusive source suppliers fail to provide bulk drugs in sufficient quantities
when required, our revenues and results of operations will be negatively
impacted.

WE DO NOT KNOW IF THE MARKET WILL ACCEPT OUR DEEP LUNG DRUG DELIVERY SYSTEM.

    The commercial success of our potential products depends upon market
acceptance by health care providers, third-party payors like health insurance
companies and Medicare, and patients. Our products under development use a new
method of drug delivery and there is a risk that our potential products will not
be accepted by the market. Market acceptance will depend on many factors,
including:

    - the safety and efficacy of our clinical trials;

    - favorable regulatory approval and product labeling;

    - the frequency of product use;

    - the availability of third-party reimbursement;

    - the availability of alternative technologies; and

    - the price of our products relative to alternative technologies.

    There is a risk that health care providers, patients or third-party payors
will not accept our deep lung drug delivery system. If the market does not
accept our potential products, our revenues and results of operations would be
significantly and negatively impacted.

IF OUR PRODUCTS ARE NOT COST EFFECTIVE, GOVERNMENT AND PRIVATE INSURANCE PLANS
  MAY NOT PAY FOR OUR PRODUCTS.

    In both domestic and foreign markets, sales of our products under
development will depend in part upon the availability of reimbursement from
third-party payors, such as government health administration authorities,
managed care providers, private health insurers and other organizations. In
addition, such third-party payors are increasingly challenging the price and
cost effectiveness of medical products and services. Significant uncertainty
exists as to the reimbursement status of newly approved health care

                                       23
<PAGE>
products. Legislation and regulations affecting the pricing of pharmaceuticals
may change before our proposed products are approved for marketing. Adoption of
such legislation and regulations could further limit reimbursement for medical
products. A government or third-party payor decision to not provide adequate
coverage and reimbursements for our products would limit market acceptance of
such products.

WE EXPECT TO CONTINUE TO LOSE MONEY FOR THE NEXT SEVERAL YEARS.

    We have never been profitable and, through December 31, 1999, we have an
accumulated deficit of approximately $94.5 million. We expect to continue to
incur substantial and increasing losses over at least the next several years as
we expand our research and development efforts, testing activities and
manufacturing operations, and as we further expand our late stage clinical and
early commercial production facility. All of our potential products are in
research or in the early stages of development except for our insulin
collaboration. We have generated no revenues from approved product sales. Our
revenues to date have consisted primarily of payments under short-term research
and feasibility agreements and development contracts. To achieve and sustain
profitable operations, we must, alone or with others, successfully develop,
obtain regulatory approval for, manufacture, introduce, market and sell products
using our deep lung drug delivery system. There is a risk that we will not
generate sufficient product or contract research revenue to become profitable or
to sustain profitability.

WE MAY NEED TO RAISE ADDITIONAL CAPITAL THAT MAY NOT BE AVAILABLE.

    We anticipate that our existing capital resources will enable us to maintain
currently planned operations through at least the next 24 months. However, this
expectation is based on our current operating plan, which is expected to change
as a result of many factors, and we may need additional funding sooner than
anticipated. In addition, we may choose to raise additional capital due to
market conditions or strategic considerations, even if we believe we have
sufficient funds for our current or future operating plans. To the extent that
additional capital is raised through the sale of equity or convertible debt
securities, the issuance of such securities could result in dilution to our
stockholders.

    We have no credit facility or other committed sources of capital. To the
extent operating and capital resources are insufficient to meet future
requirements, we will have to raise additional funds to continue the development
and commercialization of our technologies. Such funds may not be available on
favorable terms, or at all. In particular, our substantial leverage may limit
our ability to obtain additional financing. If adequate funds are not available
on reasonable terms, we may be required to curtail operations significantly or
to obtain funds by entering into financing, supply or collaboration agreements
on unattractive terms. Our inability to raise capital could negatively impact
our business.

OUR PATENTS MAY NOT PROTECT OUR PRODUCTS AND OUR PRODUCTS MAY INFRINGE ON
  THIRD-PARTY PATENT RIGHTS.

    We have filed patent applications covering certain aspects of our device,
powder processing technology, and powder formulations and deep lung route of
delivery for certain molecules, and we plan to file additional patent
applications. We currently have 49 issued U.S. and foreign patents that cover
certain aspects of our technology and we have a number of patent applications
pending. There is a risk that many of the patents applied for will not issue, or
that any patents that issue or have issued will not be valid and enforceable.
Enforcing our patent rights would be time consuming and costly.

    Our access or our partners' access to the drugs to be formulated will affect
our ability to develop and commercialize our technology. Many drugs, including
powder formulations of certain drugs that are presently under development by us,
are subject to issued and pending U.S. and foreign patents that may be owned by
our competitors. We know that there are issued patents and pending patent
applications relating to the deep lung delivery of large molecule drugs,
including several for which we are developing deep lung delivery formulations.
This situation is highly complex, and the ability of any one company, including
Inhale, to commercialize a particular drug is unpredictable.

                                       24
<PAGE>
    We intend generally to rely on the ability of our partners to provide access
to the drugs that are to be formulated by us for deep lung delivery. There is a
risk that our partners will not be able to provide access to such drug
candidates. Even if such access is provided, there is a risk that our partners
or we will be accused of, or determined to be, infringing a third-party's patent
rights and will be prohibited from working with the drug or be found liable for
damages that may not be subject to indemnification. Any such restriction on
access to drug candidates or liability for damages would negatively impact our
revenues and results of operations.

OUR COMPETITORS MAY DEVELOP AND SELL BETTER DRUG DELIVERY SYSTEMS.

    We are aware of other companies engaged in developing and commercializing
pulmonary drug delivery systems and enhanced injectable drug delivery systems.
Many of these companies have greater research and development capabilities,
experience, manufacturing, marketing, financial and managerial resources than we
do and represent significant competition for us. Acquisitions of or
collaborations with competing drug delivery companies by large pharmaceutical
companies could enhance our competitors' financial, marketing and other
resources. Accordingly, our competitors may succeed in developing competing
technologies, obtaining regulatory approval for products or gaining market
acceptance before us. Developments by others could make our products or
technologies uncompetitive or obsolete. Our competitors may introduce products
or processes competitive with or superior to ours.

INVESTORS SHOULD BE AWARE OF INDUSTRY-WIDE RISKS.

    In addition to the risks associated specifically with Inhale described
above, investors should also be aware of general risks associated with drug
development and the pharmaceutical industry. These include, but are not limited
to:

    - changes in and compliance with government regulations;

    - handling of hazardous materials;

    - hiring and retaining qualified people; and

    - insuring against product liability claims.

WE EXPECT OUR STOCK PRICE TO REMAIN VOLATILE.

    Our stock price is volatile. In the last twelve months, based on closing
prices on the Nasdaq National Market, our stock price ranged from $23.00 to
$126.62. We expect it to remain volatile. A variety of factors may have a
significant effect on the market price of our common stock, including:

    - fluctuations in our operating results;

    - announcements of technological innovations or new therapeutic products;

    - announcement or termination of collaborative relationships by Inhale or
      our competitors;

    - governmental regulation;

    - clinical trial results or product development delays;

    - developments in patent or other proprietary rights;

    - public concern as to the safety of drug formulations developed by Inhale
      or others; and

    - general market conditions.

Any litigation brought against us as a result of this volatility could result in
substantial costs and a diversion of our management's attention and resources,
which could negatively impact our financial condition, revenues and results of
operations.

                                       25
<PAGE>
THE NOTES ARE SUBORDINATED TO ANY EXISTING AND FUTURE SENIOR DEBT.

    The notes are contractually subordinated in right of payment to our existing
and future Senior Debt. As of December 31, 1999, we had approximately
$4.9 million of Senior Debt. Upon the closing of our sale of 6 3/4% Convertible
Subordinated Debentures in late 1999, we incurred additional indebtedness of
approximately $108.5 million. In early 2000, we entered into agreements with
certain holders of such debentures to reduce the principal amount of debentures
outstanding by approximately $94.2 million. The indenture does not limit the
creation of additional Senior Debt (or any other indebtedness). In connection
with the expansion of our facilities, we expect that we may significantly
increase our Senior Debt in the near future. Any significant additional Senior
Debt incurred may materially adversely impact our ability to service our debt,
including the notes. Due to the subordination provisions, in the event of our
insolvency, funds which we would otherwise use to pay the holders of the notes
will be used to pay the holders of Senior Debt to the extent necessary to pay
the Senior Debt in full. As a result of these payments, our general creditors
may recover less, ratably, than the holders of our Senior Debt and such general
creditors may recover more, ratably, than the holders of our notes or our other
subordinated indebtedness. In addition, the holders of our Senior Debt may,
under certain circumstances, restrict or prohibit us from making payments on the
notes.

OUR OUTSTANDING INDEBTEDNESS HAS INCREASED SUBSTANTIALLY WITH THE ISSUANCE OF
  THE 5% CONVERTIBLE NOTES.

    As of December 31, 1999, we had approximately $113.3 million in long-term
debt. Upon the closing of our sale of 5.0% convertible subordinated notes in
early 2000, we incurred additional long-term indebtedness of $230.0 million. In
early 2000, we entered into agreements with certain holders of the October 2006
debentures to reduce the principal amount of debentures outstanding by
approximately $94.2 million. Upon closing of the offering of the notes, our
long-term debt was approximately $249.2 million. This increased indebtedness has
and will continue to impact us by:

    - significantly increasing our interest expense and related debt service
      costs;

    - making it more difficult to obtain additional financing; and

    - constraining our ability to react quickly in an unfavorable economic
      climate.

    Currently, we are not generating sufficient cash flow to satisfy the annual
debt service payments that will be required as a result of the consummation of
sale of the notes. This may require us to use a portion of the proceeds from the
sales of the notes to pay interest or borrow additional funds or sell additional
equity to meet our debt service obligations. If we are unable to satisfy our
debt service requirements, substantial liquidity problems could result, which
would negatively impact our future prospects.

ITEM 2. PROPERTIES

    Inhale currently leases approximately 156,000 square feet in San Carlos,
California, 20,000 square feet in Palo Alto, California and 8,000 square feet in
Belmont, California. The Palo Alto facility is used for research, development
and administration; the lease has a five-year term, and expires on May 31, 2003.
The Belmont facility is used for administration; the lease has a 30-month term
and expires on June 30, 2003.

    The San Carlos facility is leased pursuant to a 15-year lease agreement. The
San Carlos facility serves as the Company's corporate headquarters and is used
for research, development, manufacturing and administration. The lease provides
Inhale with an option to lease approximately 69,000 additional square feet in
the same facility. This manufacturing facility operates under current good
manufacturing practices and has been approved and licensed by the State of
California to manufacture clinical supplies for use in clinical trials.

                                       26
<PAGE>
    In October 1998, Inhale acquired 4.7 acres of land adjacent to its San
Carlos facility. Inhale intends to use this property to expand future
operations. In October 1999, Inhale commenced construction of an 85,000 square
foot facility on this site to expand its administrative offices and research and
development capacity.

ITEM 3. LEGAL PROCEEDINGS

    Not applicable.

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

    No matters were submitted to a vote of Inhale's shareholders in the quarter
ended December 31, 1999.

                                    PART II

ITEM 5. MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED SHAREHOLDER MATTERS

                          PRICE RANGE OF COMMON STOCK

    Inhale's Common Stock trades on the Nasdaq National Market under the symbol
INHL. The table below sets forth the high and low closing sales prices for
Inhale's Common Stock (as reported on the Nasdaq National Market) during the
periods indicated.

<TABLE>
<CAPTION>
                                                                PRICE RANGE OF
                                                                 COMMON STOCK
                                                              -------------------
YEAR ENDED DECEMBER 31, 1998:                                   HIGH       LOW
- -----------------------------                                 --------   --------
<S>                                                           <C>        <C>
1(st) Quarter...............................................  $ 34.250   $25.250
2(nd) Quarter...............................................    34.000    23.125
3(rd) Quarter...............................................    29.875    21.750
4(th) Quarter...............................................    33.375    21.500

YEAR ENDED DECEMBER 31, 1999:
- ------------------------------------------------------------
1(st) Quarter...............................................  $ 34.625   $23.875
2(nd) Quarter...............................................    29.688    23.000
3(rd) Quarter...............................................    34.875    23.625
4(th) Quarter...............................................    43.688    26.875

YEAR ENDED DECEMBER 31, 2000:
- ------------------------------------------------------------
1(st) Quarter (through March 9, 2000).......................  $126.625   $41.688
</TABLE>

    As of December 31, 1999, there were approximately 225 holders of record of
Inhale's Common Stock. Inhale has not paid any cash dividends since its
inception and does not intend to pay any cash dividends in the foreseeable
future.

                                       27
<PAGE>
                          RELATED STOCKHOLDER MATTERS

    In February 2000 we issued $230,000,000 aggregate principal amount of
convertible subordinated notes, which are convertible at the option of the
holder, at any time on or prior to maturity into shares of our common stock. The
notes were sold only in the United States to certain qualified institutional
buyers under an exemption from registration provided by Rule 144A of the
Securities Act of 1933, as amended. The notes are convertible at a conversion
price of $76.71 per share, which is equal to a conversion rate of approximately
13.037 shares per $1,000 principal amount of notes, subject to adjustment.
Interest on the debentures will accrue at a rate of 5.0% per year subject to
adjustment in certain circumstances . We will pay interest on the notes on
February 8 and August 8 of each year, beginning August 8, 2000. The notes mature
on February 8, 2007. We may redeem some or all of the notes at any time before
February 8, 2003 at a redemption price of $1,000 per $1,000 principal amount of
notes, plus accrued and unpaid interest, if any, to the redemption date, if the
closing price of our common stock has exceeded 150% of the conversion price then
in effect for at least 20 trading days within a period of 30 consecutive trading
days ending on the trading day before the date of mailing of the provisional
redemption notice. We will make additional payment in cash with respect to the
notes, call for provisional redemption in an amount equal to $13.93 per $1,000
principal amount of notes, less the amount of any interest actually paid on the
notes before the call for redemption. We may redeem some or all of the notes at
any time after February 8, 2003. The notes are unsecured and subordinated to our
existing and future senior indebtedness. Merrill Lynch & Co. served as the sole
bookrunner for the offering and received approximately $7,187,500 in discounts
and commissions.

    In October and November of 1999 we issued $108,450,000 aggregate principal
amount of convertible subordinated debentures, which are convertible at the
option of the holder, at any time on or prior to maturity into shares of our
common stock. The debentures were sold only in the United States to certain
qualified institutional buyers under an exemption from registration provided by
Rule 144A of the Securities Act of 1933, as amended. The debentures are
convertible at a conversion price of $32.0075 per share, which is equal to a
conversion rate of approximately 31.2427 shares per $1,000 principal amount of
notes, subject to adjustment. Interest on the debentures will accrue at a rate
of 6 3/4% per year subject to adjustment in certain circumstances . We will pay
interest on the notes on April 13 and October 13 of each year, beginning April
13, 2000. The debentures mature on October 13, 2006. We may redeem some or all
of the debentures after October 13, 2002 at the following prices (expressed in
percentage of the principal amount), together with accrued and unpaid interest
to, but excluding, the date fixed for redemption:

<TABLE>
<CAPTION>
DURING THE TWELVE MONTHS COMMENCING                           REDEMPTION PRICE
- -----------------------------------                           ----------------
<S>                                                           <C>
October 13, 2002............................................      103.375%
October 13, 2003............................................      102.250%
October 13, 2004............................................      101.125%
October 13, 2005............................................      100.000%
</TABLE>

    The debentures are unsecured and subordinated to our existing and future
senior indebtedness. The initial purchasers of the debentures, Lehman Brothers
Inc., Deutsche Bank Securities Inc. and U.S. Bancorp Piper Jaffray Inc.,
received an aggregate of approximately $3,253,500 in discounts and commissions
relating to this offering. On January 26, 2000 a shelf registration statement
for the debentures and the shares of common stock issuable upon conversion of
the debentures was declared effective by the SEC. In early, 2000, we entered
into agreements with certain holders of these outstanding debentures to convert
their debentures into shares of our common stock in exchange for a cash payment
made by Inhale. To date, we have agreed to make cash payments of approximately
$16.2 million in the aggregate in connection with agreements that provide for
the conversion of approximately $94.2 million aggregate principal amount of
outstanding debentures.

    On November 4, 1999 we issued to Alliance Pharmaceutical Corp. 180,099
shares of our common stock having a market value of $5.0 million in a private
placement exempt from registration under Section 4(2) of the Securities Act of
1933, as amended. We issued these shares and paid $15.0 million in cash to
Alliance in exchange for acquiring Alliance's PulmoSpheres-Registered Trademark-
technology and other related assets

                                       28
<PAGE>
for particle formation and powder processing. Alliance is a sophisticated,
qualified investor and defined as an "accredited investor" under
Rule 501(a) of the Securities Act, as amended, and acquired these shares in the
ordinary course of its business for its own account for investment and not with
a view to, or any arrangements or understandings regarding, any subsequent
distributions. Alliance signed a Stock Purchase Agreement in which it made
certain representations and warranties to us that they met the criteria to be
eligible for this exemption from registration. No underwriters were involved in
this offering and no commissions or remuneration was paid in connection with the
sales of these shares.

    On December 9, 1998 we issued 1,200,000 shares of our common stock to two
affiliated entities, Smallcap World Fund, Inc. and American Variable Insurance
Series Growth Fund, which are managed by Capital Research and Management
Company, at a purchase price of $31 per share, for an aggregate amount of
$37.2 million in cash in a private placement exempt from registration under
Section 4(2) of the Securities Act of 1933, as amended. These purchasers of
shares of our common stock are qualified investors and institutions defined as
"accredited investors" under Rule 501(a) of the Securities Act, as amended, and
acquired these shares in the ordinary course of their business for their own
account for investment and not with a view to, or any arrangements or
understandings regarding, any subsequent distributions. These purchasers signed
a Stock Purchase Agreement in which they made certain representations and
warranties to us that they met the criteria to be eligible for this exemption
from registration. Volpe Brown Whelan & Company served as the exclusive
placement agent in connection with this offering and received $1,886,040 in
payment of certain fees and commissions. On February 11, 1999, a shelf
registration statement for these shares of common stock was declared effective
by the SEC.

    On April 13, 1998 we issued an aggregate of 5,781 shares of our common stock
to several individuals who are affiliated with Boyce Thompson Institute for
Plant Research, Inc. and Initiatech, Inc. in partial consideration for Inhale
signing an agreement with Initiatech, Inc. under which Inhale licenses
technology, intellectual property, and patents for protecting biologically
active compounds in the dry state. Initiatech has licensed exclusive rights to
this technology from the Boyce Thompson Institute for Plant Research, Inc. These
shares were sold in a private placement exempt from registration under
Section 4(2) of the Securities Act of 1933, as amended. No underwriters were
involved in this offering and no commissions or remuneration was paid in
connection with the sales of these shares.

    On February 7, 1997 we issued 1,800,000 shares of our common stock at a
purchase price of $18 per share, for an aggregate amount of $32.4 million in
cash in private transactions exempt from registration under Rule 506 of
Regulation D promulgated under the Securities Act of 1933, as amended to
selected institutions qualified as "accredited investors" under Rule 501(a) of
Regulation D. These purchasers acquired our shares in the ordinary course of
their business for their own account for investment and not with a view to, or
any arrangements or understandings regarding, any subsequent distributions.
These purchasers each signed a Purchase Agreement in which they made certain
representations and warranties to us that they met the criteria to be eligible
for this exemption from registration. Vector Securities International, Inc.
served as the exclusive placement agent in connection with this offering and
received $1,782,000 in payment of certain fees and commissions. On February 7,
1997 a shelf registration statement for these shares of common stock was
declared effective by the SEC.

    On June 27, 1997 we sold 28,165 shares of our common stock to Pafra Limited
for an aggregate purchase price of $600,000 in a private placement exempt from
registration under Section 4(2) of the Securities Act of 1933, as amended. We
issued these shares to Pafra in partial consideration for Pafra's assignment to
Inhale of certain of its intellectual property rights, the goodwill and
know-how. Pafra is a sophisticated, qualified investor and defined as an
"accredited investor" under Rule 501(a) of the Securities Act, as amended, and
acquired these shares in the ordinary course of it business for its own account
for investment and not with a view to, or any arrangements or understandings
regarding, any subsequent distributions. Pafra signed an assignment in which it
made certain representations and warranties to us that they met the criteria to
be eligible for this exemption from registration. No underwriters were involved
in this offering and no commissions or remuneration was paid in connection with
the sales of these shares.

                                       29
<PAGE>
ITEM 6.  SELECTED FINANCIAL DATA

                         SELECTED FINANCIAL INFORMATION
                  (IN THOUSANDS, EXCEPT PER SHARE INFORMATION)

<TABLE>
<CAPTION>
                                                           YEARS ENDED DECEMBER 31
                                             ----------------------------------------------------
                                               1999       1998       1997       1996       1995
                                             --------   --------   --------   --------   --------
<S>                                          <C>        <C>        <C>        <C>        <C>
STATEMENT OF OPERATIONS DATA:
  Contract research revenue................  $ 41,358   $ 21,795   $ 16,249   $  6,890   $  3,445
  Operating costs and expenses:
    Research and development...............    64,083     35,398     23,645     14,376      9,041
    General and administrative.............     7,869      8,387      6,328      4,004      3,232
    Acquired in-process research and
      development..........................     9,890         --         --         --         --
                                             --------   --------   --------   --------   --------
  Total operating costs and expenses.......    81,842     43,785     29,973     18,380     12,273
                                             --------   --------   --------   --------   --------
  Loss from operations.....................   (40,484)   (21,990)   (13,724)   (11,490)    (8,828)

  Interest income (expense), net...........     2,036      3,634      3,741      1,581      1,166
                                             --------   --------   --------   --------   --------
  Net loss.................................  $(38,448)  $(18,356)  $ (9,983)  $ (9,909)  $ (7,662)
                                             ========   ========   ========   ========   ========
  Net loss per share.......................  $  (2.26)  $  (1.17)  $  (0.72)  $  (0.88)  $  (0.78)
                                             ========   ========   ========   ========   ========
  Shares used in computation of net loss
    per share(1)...........................    17,008     15,719     13,792     11,207      9,837
                                             ========   ========   ========   ========   ========
</TABLE>

<TABLE>
<CAPTION>
                                                                 DECEMBER 31,
                                             ----------------------------------------------------
                                               1999       1998       1997       1996       1995
                                             --------   --------   --------   --------   --------
<S>                                          <C>        <C>        <C>        <C>        <C>
BALANCE SHEET DATA:
  Cash, cash equivalents and short-term
    investments............................  $138,185   $ 82,862   $100,173   $ 36,309   $ 19,927
  Working capital..........................   122,239     71,784     83,811     31,304     17,701
  Total assets.............................   226,806    134,496    119,762     41,492     23,248
  Long-term debt...........................     4,895      4,940      5,102        187        353
  Convertible subordinated debentures......   108,450         --         --         --         --
  Accumulated deficit......................   (94,466)   (56,018)   (37,662)   (27,691)   (17,770)
  Total stockholders' equity...............    86,629    115,881     97,093     35,061     20,182
</TABLE>

- ------------------------

(1) Basic and diluted net loss per share is based upon the weighted average
    number of common shares outstanding. All share amounts have been adjusted to
    reflect the implementation of FASB Statement No. 128 and Staff Accounting
    Bulletin No. 98. See Note 1 of Notes to Financial Statements.

                                       30
<PAGE>
ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
         OF OPERATIONS

    THE FOLLOWING DISCUSSION CONTAINS FORWARD-LOOKING STATEMENTS THAT INVOLVE
RISKS AND UNCERTAINTIES. INHALE'S ACTUAL RESULTS COULD DIFFER MATERIALLY FROM
THOSE DISCUSSED HERE. FACTORS THAT COULD CAUSE OR CONTRIBUTE TO SUCH DIFFERENCES
INCLUDE, BUT ARE NOT LIMITED TO, THOSE DISCUSSED IN THIS SECTION AS WELL AS IN
PART I OF THIS ANNUAL REPORT UNDER THE HEADING "RISK FACTORS".

OVERVIEW

    Since its inception in July 1990, Inhale has been engaged in the development
of a pulmonary system for the delivery of macromolecules and other drugs for
systemic and local lung applications. Inhale has been unprofitable since
inception and expects to incur significant and increasing additional operating
losses over the next several years primarily due to increasing research and
development expenditures and expansion of late stage clinical and early stage
commercial manufacturing facilities. To date, Inhale has not sold any commercial
products and does not anticipate receiving revenue from product sales or
royalties in the near future. For the period from inception through
December 31, 1999, Inhale incurred a cumulative net loss of approximately
$94.5 million. Inhale's sources of working capital have been partner fundings,
including milestone payments, from short-term research and feasibility
agreements and development contracts, equity financings, financings of equipment
acquisitions and tenant improvements, and interest earned on investments of
cash.

    Inhale has generally been compensated for research and development expenses
during initial feasibility work performed under collaborative arrangements.
Partners that enter into collaborative agreements generally pay for some or all
research and development expenses and make additional payments to Inhale as
Inhale achieves certain key milestones. Inhale expects to receive royalties from
its partners based on their revenues received from product sales, and to receive
revenue from the manufacturing of powders and the supply of devices. In certain
cases, Inhale may enter into collaborative agreements under which Inhale's
partners would manufacture or package powders or supply inhalation devices,
thereby potentially limiting one or more sources of revenue for Inhale. To
achieve and sustain profitable operations, Inhale, alone or with others, must
successfully develop, obtain regulatory approval for, manufacture, introduce,
market and sell products utilizing its pulmonary drug delivery system. There can
be no assurance that Inhale can generate sufficient product or contract research
revenue to become profitable or to sustain profitability.

    In late 1999, Inhale completed the sale of approximately $108.5 million
aggregate principal amount of 6 3/4% Convertible Subordinated Debentures due
October 13, 2006. In early 2000, the Company entered into agreements with
certain holders of these outstanding debentures to convert their debentures into
common stock in exchange for a cash payment. To date, the Company has agreed to
make cash payments of approximately $16.2 million in the aggregate in connection
with agreements that provide for the conversion of approximately $94.2 million
aggregate principal amount of outstanding debentures into approximately
2.9 million shares of common stock. Such amounts will be reflected as a charge
to interest expense in the first quarter of 2000.

    In February, 2000, Inhale received approximately $222.4 million in net
proceeds from the issuance of $230.0 million aggregate principal amount of
convertible subordinated debentures to certain qualified institutional buyers
under Rule 144A of the Securities Act of 1933, as amended. Interest on the
debentures will accrue at a rate of 5.0% per year, subject to adjustment in
certain circumstances. The debentures will mature in 2007 and are convertible
into shares of Inhale's common stock at a conversion price of $76.71 per share,
subject to adjustment in certain circumstances.

                                       31
<PAGE>
RESULTS OF OPERATIONS

YEARS ENDED DECEMBER 31, 1999, 1998 AND 1997

    Contract research revenue was $41.4 million for the year ended December 31,
1999 compared to $21.8 million and $16.2 million for the years ended
December 31, 1998 and 1997, respectively. Revenue increased 90% in 1999 from
1998 levels and 34% in 1998 from 1997 levels. Costs of contract research revenue
approximate such revenue and are included in research and development expense.

    The 90% increase in revenue for the year ended December 31, 1999 as compared
to December 31, 1998 was primarily due to expansion of Inhale's existing
collaborative agreement with Pfizer, and includes activities associated with the
manufacture of Phase III clinical supplies. Pfizer represented approximately 71%
of Inhale's revenues for the year ended December 31, 1999. Revenue for 1999 and
1998 included reimbursed research and development expenses as well as the
amortization of up-front signing and progress payments received from Inhale's
collaborative partners. Recognition of up-front signing and progress payments is
based on actual efforts expended. Contract revenues are expected to fluctuate
from year to year, and future contract revenues cannot be predicted accurately.
The level of contract revenues depends in part upon future success in obtaining
new collaborative agreements, timely completion of feasibility studies, the
continuation of existing collaborations and achievement of milestones under
current and future agreements.

    Research and development expenses were $64.1 million for the year ended
December 31, 1999, as compared to $35.4 million and $23.6 million for the years
ended December 31, 1998 and 1997, respectively. These expenses represent
proprietary research expenses as well as the costs related to contract research
revenue and include the salaries and benefits of scientific and development
personnel, clinical manufacturing costs, laboratory supplies, consulting
services, facilities, costs of obtaining intellectual property protection for
Inhale's technologies and expenses associated with the development of
manufacturing processes. The 81% increase in such expenses in 1999 from 1998 was
due to increased spending related to the scale-up of technologies and the
continuing development of global manufacturing capabilities in order to support
Phase III inhaleable insulin clinical trials and commercial production. In
addition, the Company hired additional scientific and development personnel to
handle an increase in the number of development projects and incurred increased
expenses associated with device development and clinical manufacturing. The
largest components of the 1999 increase in research and development were the
increases of $11.8 million in salaries and employee benefits expense, a
$9.3 million increase in research and development supplies and services, and a
$3.8 million increase in facilities and administrative expense allocations
associated with supporting the research and development efforts. The
$11.8 million increase in research and development expenses in 1998 from 1997
was primarily attributable to the development of infrastructure necessary to
manufacture the Company's products on a late stage clinical scale. Inhale
expects research and development spending to increase over the next few years as
Inhale expands its development efforts under collaborative agreements and scales
up its commercial manufacturing facility.

    General and administrative expenses were $7.9 million for the year ended
December 31, 1999 as compared to $8.4 million and $6.3 million for the years
ended December 31, 1998 and 1997, respectively. The $0.5 million decrease in
general and administrative expenses in 1999 from 1998 is attributed to an
increased percentage of general and administrative related costs allocated to
research and development operations. The $2.1 million increase in such expenses
in 1998 was due primarily to costs associated with supporting Inhale's increased
research efforts including administrative staffing, business development
activities and marketing activities. General and administrative expenses are
expected to continue to increase over the next few years as Inhale expands its
operations.

    Interest income was $4.1 million for the year ended December 31, 1999 as
compared to $3.9 million and $3.8 million for the years ended December 31, 1998
and 1997, respectively. The 5% increase in interest income in 1999 from 1998 and
the 3% increase in interest income in 1998 from 1997 were primarily due to
Inhale maintaining larger cash and investment balances, including the proceeds
of its October, 1999

                                       32
<PAGE>
issuance of convertible subordinated debentures which resulted in net proceeds
of $105.2 million. Interest expense was $2.1 million for the year ended
December 31, 1999, as compared to $0.3 million and $0.1 million for the years
ended December 31, 1998 and 1997, respectively. The $1.8 million increase in
interest expense in 1999 from 1998 primarily relates to interest on the
above-mentioned convertible subordinated debentures. The $0.2 million increase
in interest expense in 1998 from 1997 related to increased debt balances,
including the proceeds of the Company's November, 1997 tenant improvement loan.

    At December 31, 1999, Inhale had federal and state net operating loss
carryforwards of approximately $92.6 million. These carryforwards will expire
beginning in the year 2000. Utilization of net operating loss carryforwards may
be subject to substantial annual limitations due to the ownership change
limitations provided for by the Internal Revenue Code of 1986. The annual
limitations may result in the expiration of net operating loss carryforwards
before utilization.

ACQUIRED IN-PROCESS RESEARCH AND DEVELOPMENT

    On November 4, 1999, Inhale concluded an agreement with Alliance
Pharmaceutical Corp. to acquire Alliance's PulmoSpheres-Registered Trademark-
particle and particle processing technology for use in respiratory drug
delivery. Under the terms of the agreement, Inhale received the rights to
PulmoSpheres-Registered Trademark- technology, other related assets (including
research materials, laboratory records, and certain equipment that had been used
in the development of PulmoSpheres technology and the manufacturing and testing
of particles using such PulmoSpheres technology), and Alliance stock valued at
$5 million in exchange for $15 million in cash and $5 million of Inhale stock.
Alliance also has the right to additional substantial payments upon the
achievement of certain milestones and royalties on a defined number of products
commercialized using the technology. $15.0 million of the purchase consideration
was allocated to the assets acquired based on their fair value on the date of
acquisition. Approximately $9.9 million of the purchase price was allocated to
in-process research and development and has been charged as an expense in the
year ended December 31, 1999.

    The PulmoSpheres-Registered Trademark- technology utilizes an emulsification
process to produce a powder having characteristics that Inhale believes may
improve efficiency and reproducibility for drugs delivered to the lung through
alternative technologies such as metered-dose inhalers ("MDI's"), as well as
potentially improve drug delivery through Inhale's proprietary deep lung drug
delivery system. Inhale evaluates this technology to be in the pre-clinical
stage of development.

    The purchased research and development had no alternative future use at the
date of acquisition. It was identified and valued through extensive interviews
and discussions with appropriate management and scientific personnel and the
analysis of data provided by Alliance regarding the
PulmoSpheres-Registered Trademark- technology, its stage of development at the
time of acquisition, the importance of the technology to Inhale's overall
development plan, and the projected incremental cash flows from the projects
when completed and any associated risks. Associated risks include the
uncertainties in overcoming significant technological risks, acquiring FDA
approval and establishing commercial viability.

    Inhale does not expect the products which utilize the
PulmoSpheres-Registered Trademark- technology to obtain FDA approval before
2005. Inhale is in process of evaluating which projects will benefit the most
from the PulmoSpheres-Registered Trademark- technology and is estimating the
associated future development costs, which are expected to be substantial
through 2006.

LIQUIDITY AND CAPITAL RESOURCES

    Inhale has financed its operations primarily through public and private
placements of its equity securities, convertible debentures, contract research
revenues, interest income earned on its investments of cash and financing of
equipment acquisitions. In its initial public offering completed May 1994,
Inhale raised net proceeds of approximately $14.4 million and raised additional
net proceeds of $7.2 million in its

                                       33
<PAGE>
public offering completed in March 1995. In February 1997, Inhale completed a
private placement of its Common Stock, selling 1.8 million newly issued shares
for net proceeds of $30.5 million. In November 1997, Inhale completed a public
offering of its Common Stock, selling 1.725 million newly issued shares for net
proceeds of $40.0 million. Inhale secured a $5 million loan in November 1997 to
finance the purchases of equipment and facility improvements. In December 1998,
Inhale completed a private placement of its Common Stock, selling 1.2 million
newly issued shares for net proceeds of $35.3 million. In October 1999, the
Company received approximately $105.2 million in net proceeds from the sale of
convertible subordinated debentures. At December 31, 1999, Inhale had cash, cash
equivalents and short-term investments of approximately $138.2 million. In
February 2000, Inhale completed the sale of convertible subordinated notes
netting proceeds of approximately $206.0 million. This includes cash payments of
approximately $16.2 million in connection with agreements that provide for the
conversion of approximately $94.2 million of its October 2006 debentures that
were outstanding at December 31, 1999.

    Inhale's operations used cash of $15.3 million and $19.2 million, and
provided cash of $5.0 million in the years ended December 31, 1999, 1998 and
1997, respectively. These amounts differed from Inhale's net operating losses in
these periods principally due to increased depreciation expense and fluctuations
in the Company's accounts receivable, other assets, accrued liabilities and
deferred revenue balances. Fluctuations in these balances reflect Inhale's
increased research, development and manufacturing activities, as well as timing
differences in the receipt of cash from Inhale's development partners.
Additionally, in 1999, Inhale, recorded a $9.9 million write-off of acquired
research and development in connection with the acquisition of
PulmoSpheres-Registered Trademark- technology.

    Inhale purchased property and equipment of approximately $20.5 million,
$34.6 million and $17.3 million during the years ended December 31, 1999, 1998
and 1997, respectively. The decrease in 1999 is primarily due to the increased
expenditures in 1998 for the purchase of land and the build out of Inhale's
manufacturing facility and corporate headquarters located in San Carlos,
California. The Company also invested $15.3 million in the purchase of
PulmoSpheres-Registered Trademark- technology in 1999, in addition to its
non-cash exchange of common stock for shares of Alliance valued at
$5.0 million.

    Inhale expects its cash requirements to continue at an accelerated rate due
to expected increases in costs associated with further research and development
of its technologies, development of drug formulations, process development for
the manufacture and filling of powders and devices, marketing and general and
administrative costs. These expenses include, but are not limited to, increases
in personnel and personnel related costs, purchases of capital equipment,
investments in technologies, inhalation device prototype construction and
facilities expansion, including the completion of Inhale's commercial
manufacturing facility and scale-up of device manufacturing with its outside
contract manufacturers.

    Given its current cash requirements, the Company believes that it will have
sufficient cash to meet its operating expense requirements for at least the next
24 months. However, the Company plans to continue to invest heavily in its
growth and the need for cash will be dependent upon the timing of these
investments. Inhale's capital needs will depend on many factors, including
continued scientific progress in its research and development arrangements,
progress with pre-clinical and clinical trials, the time and costs involved in
obtaining regulatory approvals, the costs of developing and the rate of scale-up
of Inhale's powder processing and packaging technologies, the timing and cost of
its late stage clinical and early commercial production facility, the costs
involved in preparing, filing, prosecuting, maintaining and enforcing patent
claims, the need to acquire licenses to new technologies and the status of
competitive products. To satisfy its long-term needs, Inhale intends to seek
additional funding, as necessary, from corporate partners and from the sale of
securities. There can be no assurance that additional funds, if and when
required, will be available to Inhale on favorable terms, if at all.

    Inhale is currently considering expansion opportunities which would likely
involve the sale and leaseback of land adjacent to its current facilities and
the development of new facilities on such land.

                                       34
<PAGE>
Inhale anticipates that its lease obligations relating to this proposal would be
approximately $60.0 million over the term of the lease, which Inhale expects to
extend approximately 15 years.

ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

    The primary objective of Inhale's investment activities is to preserve
principal while at the same time maximizing yields without significantly
increasing risk. To achieve this objective, Inhale invests in highly liquid and
high quality debt securities. Inhale's investments in debt securities are
subject to interest rate risk. To minimize the exposure due to an adverse shift
in interest rates, Inhale invests in short term securities and maintains an
average maturity of one year or less. A hypothetical 50 basis point increase in
interest rates would result in an approximate $291,000 decrease (less than
0.217%) in the fair value of Inhale's available-for-sale securities.

    The potential change noted above is based on sensitivity analyses performed
on Inhale's financial position at December 31, 1999. Actual results may differ
materially. The same hypothetical 50 basis point increase in interest rates
would have resulted in an approximate $150,000 decrease (less than 0.185%) in
the fair value of Inhale's available-for-sale securities at December 31, 1998.

    Increases in interest rates could adversely affect the fair market value of
Inhale's convertible subordinated debentures, which pay a fixed rate of
interest.

ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

    The financial statements for the years ended December 31, 1999, 1998 and
1997 are submitted as a separate section of this report. See Item 14.

ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
         FINANCIAL DISCLOSURE

    Not Applicable.

                                       35
<PAGE>
                                    PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

    Inhale incorporates by reference the information concerning its directors
set forth under the heading "Election of Directors" in Inhale's definitive Proxy
Statement to be filed for its 2000 Annual Meeting of Shareholders.

    EXECUTIVE OFFICERS AND DIRECTORS

    The following table sets forth the names, ages and positions of the
executive officers and directors as of December 31, 1999:

<TABLE>
<CAPTION>
NAME                                          AGE                       POSITION
- ----                                        --------   ------------------------------------------
<S>                                         <C>        <C>
Robert B. Chess...........................     43      Chairman and Co-Chief Executive Officer
                                                       Co-Chief Executive Officer, President and
Ajit S. Gill..............................     51      Director
                                                       Vice President of Finance and
Brigid A. Makes...........................     44      Administration, Chief Financial Officer
Stephen L. Hurst..........................     44      General Counsel and Secretary
John S. Patton, Ph.D......................     53      Vice President, Research and Director
Robert M. Platz...........................     48      Vice President, Technology
Mark J. Gabrielson........................     43      Director
James B. Glavin...........................     64      Director
Irwin Lerner..............................     69      Director
Melvin Perelman, Ph.D.....................     69      Director
</TABLE>

    ROBERT B. CHESS has served as Chairman of the Board of Directors since
April 1999 and Co-Chief Executive Officer since August 1998. Mr. Chess served as
President from December 1991 to August 1998 and as Chief Executive Officer from
May 1992 to September 1998. Mr. Chess was elected a Director in May 1992. From
September 1990 until October 1991, he was an Associate Deputy Director in the
White House Office of Policy Development. In March 1987, Mr. Chess co-founded
Penederm Incorporated ("Penederm"), a topical dermatological drug delivery
company, and served as its President until February 1989. He left Penederm in
October 1989. Prior to co-founding Penederm, Mr. Chess held management positions
at Intel Corp., a semiconductor manufacturer, and Metaphor, a computer software
company (acquired by International Business Machines). Mr. Chess holds a BS in
Engineering from the California Institute of Technology and an MBA from the
Harvard Business School.

    AJIT S. GILL has served as President since April 1999, as Co-Chief Executive
Officer since August 1998 and as a Director since April 1998. Mr. Gill served as
Chief Operating Officer from October 1996 to August 1998 and Chief Financial
Officer from January 1993 until October 1996. Before joining Inhale, Mr. Gill
was Vice President and General Manager of Kodak's Interactive Systems division.
Mr. Gill has served as Chief Financial Officer for TRW-Fujitsu, Director of
Business Development for Visicorp, and as start-up President for three high
technology companies. He completed a BTech at the Indian Institute of
Technology, an MS in Electrical Engineering from the University of Nebraska, and
holds an MBA from the University of Western Ontario.

    BRIGID A. MAKES has served as Vice President of Finance and Administration
and Chief Financial Officer since June 1999. From 1998 until joining Inhale,
Ms. Makes served as Vice President, Chief Financial Officer and Treasurer for
Oravax, Inc., a life sciences company. From 1992 to 1998, Ms. Makes served in
various management positions for Haemonetics Corporation, developer of automated
blood processing systems, including, from 1995 to 1998, Vice President Finance,
Chief Financial Officer and Treasurer. Ms. Makes holds a Bachelor of Commerce
degree from McGill University in Finance and International Business and an MBA
from Bentley College.

                                       36
<PAGE>
    STEPHEN L. HURST has been General Counsel and Secretary since August 1998.
Mr. Hurst served as Vice President, Intellectual Property and Licensing of
Inhale from March 1994 to August 1998. From July 1990 to February 1994,
Mr. Hurst was in private law practice and consulted with COR
Therapeutics, Inc., a biotechnology company, on intellectual property and
business development issues. From November 1987 to June 1990, he was the Campus
Patent Coordinator for the University of California, San Francisco. He also
worked as an Associate Counsel at Townsend & Townsend, the San Francisco area's
largest intellectual property law firm. He received a BS degree in Environmental
Science from the University of California at Berkeley and his JD from Golden
Gate University in San Francisco.

    JOHN S. PATTON, PH.D., a co-founder of Inhale, has been Vice President,
Research since December 1991 and a Director since July 1990. He served as
President of Inhale from its incorporation in July 1990 to December 1991. From
1985 to 1990, Dr. Patton was a Project Team Leader with Genentech, Inc., a
biotechnology company, where he headed their non-invasive drug delivery
activities. Dr. Patton was on the faculty of the Marine Science and Microbiology
Departments at the University of Georgia from 1979 through 1985, where he was
granted tenure in 1984. Dr. Patton received a BS in Zoology and Biochemistry
from Pennsylvania State University, an MS from the University of Rhode Island, a
Ph.D. in Biology from the University of California, San Diego and received post
doctorate fellowships from Harvard Medical School and the University of Lund,
Sweden both in biomedicine.

    ROBERT M. PLATZ, a co-founder of Inhale, has served as Vice President,
Technology since August 1990. He also served as a Director of Inhale from
July 1990 to August 1991. From January 1983 to August 1991, Mr. Platz was
employed by SRI International, a contract research company, most recently as
Senior Chemical Engineer, where he headed the pharmaceutical aerosol group.
Mr. Platz received a BS in biology and an MS in Chemical Engineering from the
University of California, Los Angeles.

    MARK J. GABRIELSON has been a Director since May 1992. Since January 1991 he
has been a general partner of Prince Ventures, L.P., a venture capital
management firm that serves as the general partner of Prince Venture Partners
III, L.P. Mr. Gabrielson is a Director of several private companies. From 1978
until joining Prince, Mr. Gabrielson served in a variety of marketing and
business development positions with SmithKline Beecham plc.

    JAMES B. GLAVIN has been a Director since May 1993. Mr. Glavin is Chairman
of the Board of The Immune Response Corporation, a biotechnology company. He was
President and Chief Executive Officer of The Immune Response Corporation from
1987 until September 1994. From 1987 to 1990, Mr. Glavin served as Chairman of
the Board of Smith Laboratories, Inc. and was President and Chief Executive
Officer from 1985 to 1989. From 1985 to 1987, he was a partner in CH Ventures, a
venture capital firm. From 1983 to 1985, he served as Chairman of the Board of
Genetic Systems Corporation, a biotechnology firm, and as its President and
Chief Executive Officer from 1981 to 1983. Mr. Glavin is a director of The
Meridian Fund and Gish Biomedical, Inc.

    IRWIN LERNER has been a Director since April 1999. Mr. Lerner served as
Chairman of the Board of Directors and of the Executive Committee of Hoffman-La
Roche Inc., a pharmaceutical and health care company, from January 1993 until
his retirement in September 1993, and from 1980 through December 1992, also
served as President and Chief Executive Officer. From September 1995 until
present, Mr. Lerner has served on the Board of Medarex, Inc., a monoclonal
antibodies products company and became Chairman of the Board in May 1997.
Mr. Lerner served as the Chairman of the Board of Sequana Therapeutics, Inc., a
biotechnology company, from May 1995 until Sequana merged with Arris
Pharmaceuticals Inc., a pharmaceutical company, to form Axys
Pharmaceuticals, Inc. in January 1998 and has served on the Board of Axys since
then. Mr. Lerner served for 12 years on the Board of Pharmaceutical
Manufacturers' Association where he chaired the Association's FDA Issues
Committee. Mr. Lerner received a B.S. and an M.B.A. from Rutgers University. He
is currently Distinguished Executive-in-Residence at Rutgers University Graduate
School of Management. Mr. Lerner is also a director of Public Service Enterprise
Group Incorporated, a diversified public utility holding company, Humana Inc.,

                                       37
<PAGE>
a health care company, Covance, Inc., a contract drug development company, and
V.I. Technologies, Inc., a blood products company.

    MELVIN PERELMAN, PH.D.  has been a Director since January 1996.
Dr. Perelman spent 36 years at Eli Lilly & Company, most recently as Executive
Vice-President and President of Lilly Research Laboratories, a position which he
held from 1986 until his retirement in 1993. Dr. Perelman served as President of
Lilly International from 1976 until 1993. Dr. Perelman is a member of the Board
of Directors of Cinergy, Inc., DataChem, Inc., Immusol, Inc. and of The Immune
Response Corporation.

SCIENTIFIC ADVISORY GROUP

    We have assembled scientific and development advisors that provide us with
expertise in critical scientific, development, engineering, manufacturing and
business issues facing Inhale. The scientific advisory group assists us on
issues related to pulmonary delivery, pulmonary toxicology, aerosol science,
government regulation, product selection and clinical trial design. Its members
are called upon individually as needed and include, among others:

<TABLE>
<CAPTION>
NAME                                          AFFILIATION                AREA OF EXPERTISE
- ----                               ---------------------------------  -----------------------
<S>                                <C>                                <C>
Joseph Brain, Ph.D...............  Professor, Chairman, Department    Pulmonary safety
                                   of Environmental Health,
                                   Director, Physiology Program,
                                   Harvard School of Public Health
Peter Byron, Ph.D................  Professor of Pharmacy, Virginia    Pharmaceutical aerosols
                                   Commonwealth University, Medical
                                   College of Virginia
Carl Grunfeld, M.D...............  Professor of Medicine, University  Endocrinology
                                   of California, San Francisco
Michael Matthay, M.D.............  Professor of Medicine and          Pulmonology
                                   Anesthesiology, University of
                                   California, San Francisco
Gerald Smaldone, M.D.............  Professor of Medicine, State       Aerosol medicine
                                   University of New York at Stony
                                   Brook
</TABLE>

REGULATORY AND DEVELOPMENT ADVISORY BOARD

    In August 1999, we formed a regulatory affairs board to assist and advise us
on matters relating to efficient and effective regulatory processing and to
better assist us and our collaborative partners in obtaining regulatory approval
for our products. The board currently includes the following:

<TABLE>
<CAPTION>
NAME                                    AFFILIATION                 AREA OF EXPERTISE
- ----                           -----------------------------  -----------------------------
<S>                            <C>                            <C>
Carl C. Peck, M.D............  Professor of Pharmacology and  Clinical and regulatory
                               Medicine, Director, Center     development strategy
                               for Drug Development,
                               Georgetown University Medical
                               Center
David Savello, Ph.D..........  Executive Vice President and   Pharmaceutical research and
                               Chief Technology Officer,      development and regulatory
                               R.P. Scherer, Inc.             affairs
Phillip B. White.............  Director, Medical Device       Device regulatory affairs
                               Consulting, AAC Consulting
</TABLE>

                                       38
<PAGE>
ITEM 11. EXECUTIVE COMPENSATION

    Inhale incorporates by reference the information set forth under the heading
"Executive Compensation" in Inhale's definitive Proxy Statement to be filed for
its 2000 Annual Meeting of Shareholders.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

    Inhale incorporates by reference the information set forth under the heading
"Security Ownership of Certain Beneficial Owners and Management" in Inhale's
definitive Proxy Statement to be filed for its 2000 Annual Meeting of
Shareholders.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

    Inhale incorporates by reference the information set forth under the heading
"Certain Transactions" in Inhale's definitive Proxy Statement to be filed for
its 2000 Annual Meeting for Shareholders.

                                       39
<PAGE>
                                    PART IV

ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K

  (a)(1) Financial Statements

    The Financial Statements required by this item, with the report of
independent auditors, are submitted in a separate section beginning on page F-1
of this report.

     (2) Financial Statement Schedules

    Schedules have been omitted because the information required to be set forth
therein is not applicable or is shown in the Financial Statements or notes
thereto.

     (3) Exhibits

    The following exhibits are filed herewith or incorporated by reference:

<TABLE>
<CAPTION>
       EXHIBIT          EXHIBIT TITLE
- ---------------------   -------------
<C>                     <S>
    2.1(1)              Agreement and Plan of Merger between Inhale Therapeutic
                          Systems, a California corporation, and Inhale Therapeutic
                          Systems (Delaware), Inc., a Delaware corporation.

    3.1(1)              Certificate of Incorporation of Registrant.

    3.2(1)              Bylaws of the Registrant.

    4.1                 Reference is made to Exhibits 3.1 and 3.2.

    4.2(2)              Restated Investor Rights Agreement among the Registrant and
                          certain other persons named therein, dated April 29, 1993,
                          as amended October 29, 1993.

    4.3(2)              Specimen stock certificate.

    4.4(3)              Stock Purchase Agreement between the Registrant and Pfizer
                          Inc., dated January 18, 1995.

    4.5(9)              Form of Purchase Agreement between the Registrant and the
                          individual Purchasers, dated January 28, 1997.

    4.6(10)             Stock Purchase Agreement between the Registrant and Capital
                          Research and Management Company, dated December 8, 1998.

    4.7(12)             Purchase Agreement among the Registrant and Lehman Brothers
                          Inc., Deutsche Bank Securities Inc. and U.S. Bancorp Piper
                          Jaffray Inc., dated October 6, 1999.

    4.8(12)             Registration Rights Agreement among the Registrant and
                          Lehman Brothers Inc., Deutsche Bank Securities Inc. and
                          U.S. Bancorp Piper Jaffray Inc., dated October 13, 1999.

    4.9(12)             Indenture between the Registrant as Issuer and Chase
                          Manhattan Bank and Trust Company, National Association, as
                          Trustee, dated October 13, 1999.

    4.10(12)            Form of Registration Rights Agreement between the Registrant
                          and Alliance Pharmaceutical Corp.

    4.11(13)            Purchase Agreement among the Registrant and Merrill Lynch &
                          Co., Merrill Lynch, Pierce, Fenner & Smith Incorporated,
                          Deutsche Bank Securities Inc., Lehman Brothers Inc., and
                          U.S. Bancorp Piper Jaffray Inc., dated February 2, 2000.

    4.12(13)            Resale Registration Rights Agreement among Registrant and
                          Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner & Smith
                          Incorporated, Deutsche Bank Securities Inc., Lehman
                          Brothers Inc., and U.S. Bancorp Piper Jaffray Inc., dated
                          February 2, 2000.
</TABLE>

                                       40
<PAGE>

<TABLE>
<CAPTION>
       EXHIBIT          EXHIBIT TITLE
- ---------------------   -------------
<C>                     <S>
    4.13(13)            Indenture between Registrant as Issuer and Chase Manhattan
                          Bank and Trust Company, National Association as Trustee,
                          dated February 8, 2000.

   10.1(4)              Registrant's 1994 Equity Incentive Plan, as amended.

   10.2(7)              Registrant's 1994 Non-Employee Directors' Stock Option Plan,
                          as amended.

   10.3(2)              Registrant's 1994 Employee Stock Purchase Plan, as amended.

   10.4(2)              Standard Industrial Lease between the Registrant and W.F.
                          Batton & Co., Inc., dated September 17, 1992, as amended
                          September 18, 1992.

   10.5(2)              Addendum IV dated April 1, 1994 to Lease dated
                          September 17, 1992, between the Registrant and W.F. Batton
                          and Marie A. Batton, dated September 17, 1992.

   10.6(6)              Amendment Agreement Number One, dated October 20, 1995, to
                          Lease dated September 17, 1992, between the Registrant and
                          W.F. Batton & Co., Inc.

   10.7(6)              Amendment Agreement Number Two, dated November 15, 1995, to
                          Lease, dated September 17, 1992, between Registrant and
                          W.F. Batton and Marie A. Batton, Trustees of the W.F.
                          Batton and Marie A. Batton Trust UTA dated January 12,
                          1998 ("Batton Trust").

   10.8(11)             Amendment Agreement Number Three, dated February 14, 1996,
                          to Lease, dated September 17, 1992, between Registrant and
                          Batton Trust.

   10.9(11)             Amendment Agreement Number Four, dated September 15, 1996,
                          to Lease, dated September 17, 1992, between Registrant and
                          Batton Trust.

   10.10(2)             Senior Loan and Security Agreement between the Registrant
                          and Phoenix Leasing Incorporated, dated September 15,
                          1993.

   10.11(2)             Sublicense Agreement between the Registrant and John S.
                          Patton, dated September 13, 1991.

   10.12(5)             Stock Purchase Agreement between the Registrant and Baxter
                          World Trade Corporation, dated March 1, 1996.

   10.13(8)             Sublease and Lease Agreement, dated October 2, 1996, between
                          the Registrant and T.M.T. Associates L.L.C. ("Landlord").

   10.14(11)            First Amendment, dated October 30, 1996, to Sublease and
                          Lease Agreement, dated October 2, 1996, between Registrant
                          and Landlord.

   10.15(11)            Letter Agreement, dated April 9, 1997, amending Sublease and
                          Lease Agreement, dated October 2, 1996, between the
                          Registrant and Landlord.

   10.16(11)            Third Amendment, dated April 16, 1997, to Sublease and Lease
                          Agreement, dated October 2, 1996, between Registrant and
                          Landlord.

   10.17(11)            Fourth Amendment, dated November 5, 1997, to Sublease and
                          Lease Agreement, dated October 2, 1996, between Registrant
                          and Landlord.

   10.18(13)            Sublease by and between Webvan Group, Inc., as sublessor and
                          Registrant, as sublessee, dated November 3, 1999.

   23.1(13)             Consent of Ernst & Young LLP, independent auditors.

   24.1(13)             Power of Attorney. Reference is made to Signature Page.

   25.1(13)             Form T-1 Statement of Eligibility and Qualification of
                          Trustee.

   27.1                 Financial Data Schedule.
</TABLE>

- ------------------------

 (1) Incorporated by reference to the indicated exhibit in Inhale's Quarterly
     Report on Form 10-Q for the quarter ended June 30, 1998.

                                       41
<PAGE>
 (2) Incorporated by reference to the indicated exhibit in Inhale's Registration
     Statement on Form S-1 (No. 33-75942), as amended.

 (3) Incorporated by reference to the indicated exhibit in Inhale's Registration
     Statement on Form S-1 (No. 33-89502), as amended.

 (4) Incorporated by reference to Inhale's Registration Statement on Form S-8
     (No. 333-59735).

 (5) Incorporated by reference to the indicated exhibit in Inhale's Quarterly
     Report on Form 10-Q for the quarter ended March 31, 1996.

 (6) Incorporated by reference to the indicated exhibit in Inhale's Annual
     Report on Form 10-K for the year ended December 31, 1995.

 (7) Incorporated by reference to the indicated exhibit in Inhale's Quarterly
     Report on Form 10-Q for the quarter ended June 30, 1996.

 (8) Incorporated by reference to the indicated exhibit in Inhale's Quarterly
     Report on Form 10-Q for the quarter ended September 30, 1996.

 (9) Incorporated by reference to Inhale's Registration Statement on Form S-3
     (No. 333-20787).

 (10) Incorporated by reference to the indicated exhibit in Inhale's
      Registration Statement on Form S-3 (No. 333-68897), as amended.

 (11) Incorporated by reference to the indicated exhibit in Inhale's Quarterly
      Report on Form 10-Q for the quarter ended June 30, 1998.

 (12) Incorporated by reference to the indicated exhibit in Inhale's
      Registration Statement on Form S-3 (No. 333-94161), as amended.

 (13) Filed herewith

    (b) Reports on Form 8-K.

       The following Report on Form 8-K was filed during the quarter ended
       December 31, 1999: A Report on Form 8-K dated October 4, 1999 pertaining
       to the Registrant's acquisition of Alliance's
       PulmoSpheres-Registered Trademark- particle and particle processing
       technology and other related assets.

    (c) See Exhibits listed under Item 14(a)(3).

    (d) Not applicable. See Item 14(a)(2).

                                       42
<PAGE>
                                   SIGNATURES

    Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, Registrant has duly caused this report to be signed on its
behalf by the undersigned, thereunto duly authorized, on the 10th day of March
2000.

<TABLE>
<S>                                                    <C>  <C>
                                                       INHALE THERAPEUTIC SYSTEMS, INC.

                                                       By:             /s/ ROBERT B. CHESS
                                                            -----------------------------------------
                                                                         Robert B. Chess
                                                             CHAIRMAN AND CO-CHIEF EXECUTIVE OFFICER

                                                                         /s/ AJIT S. GILL
                                                            -----------------------------------------
                                                                           Ajit S. Gill
                                                                   CO-CHIEF EXECUTIVE OFFICER,
                                                                      PRESIDENT AND DIRECTOR
</TABLE>

                               POWER OF ATTORNEY

    KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints, Ajit S. Gill as his attorney-in-fact for him in
any and all capacities, to sign any and all amendments to this report on
Form 10-K, and to file the same, with exhibits thereto and other documents in
connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that the said attorney-in-fact, or his substitutes,
may do or cause to be done by virtue hereof.

    Pursuant to the requirements of the Securities Exchange Act of 1934, this
report has been signed below by the following persons on behalf of the
registrant and in the capacities and on the dates indicated.

<TABLE>
<CAPTION>
                      SIGNATURE                                    TITLE                    DATE
                      ---------                                    -----                    ----
<C>                                                    <S>                             <C>
                                                       Chairman and Co-Chief
                 /s/ ROBERT B. CHESS                     Executive Officer
     -------------------------------------------         (CO-PRINCIPAL EXECUTIVE       March 10, 2000
                   Robert B. Chess                       OFFICER)

                                                       Co-Chief Executive Officer,
                  /s/ AJIT S. GILL                       President and Director
     -------------------------------------------         (CO-PRINCIPAL EXECUTIVE       March 10, 2000
                    Ajit S. Gill                         OFFICER)

                                                       Vice President of Finance and
                 /s/ BRIGID A. MAKES                     Administration, Chief
     -------------------------------------------         Financial Officer (PRINCIPAL  March 10, 2000
                   Brigid A. Makes                       FINANCIAL AND ACCOUNTING
                                                         OFFICER

                 /s/ JOHN S. PATTON
     -------------------------------------------       Vice President, Research and    March 10, 2000
                   John S. Patton                        Director
</TABLE>

                                       43
<PAGE>

<TABLE>
<CAPTION>
                      SIGNATURE                                    TITLE                    DATE
                      ---------                                    -----                    ----
<C>                                                    <S>                             <C>
               /s/ MARK J. GABRIELSON
     -------------------------------------------       Director                        March 10, 2000
                 Mark J. Gabrielson

                 /s/ JAMES B. GLAVIN
     -------------------------------------------       Director                        March 10, 2000
                   James B. Glavin

                 /s/ MELVIN PERELMAN
     -------------------------------------------       Director                        March 10, 2000
                   Melvin Perelman

                  /s/ IRWIN LERNER
     -------------------------------------------       Director                        March 10, 2000
                    Irwin Lerner
</TABLE>

                                       44
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.
                         INDEX TO FINANCIAL STATEMENTS

<TABLE>
<CAPTION>
                                                                PAGE
                                                              --------
<S>                                                           <C>
Report of Ernst & Young LLP, Independent Auditors...........    F-2
Balance Sheets at December 31, 1999 and 1998................    F-3
Statements of Operations for each of the three years in the
  period ended December 31, 1999............................    F-4
Statement of Stockholders' Equity for each of the three
  years in the period ended December 31, 1999...............    F-5
Statements of Cash Flows for each of the three years in the
  period ended December 31, 1999............................    F-6
Notes to Financial Statements...............................    F-7
</TABLE>

                                      F-1
<PAGE>
               REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

The Board of Directors and Stockholders
Inhale Therapeutic Systems, Inc.

    We have audited the accompanying balance sheets of Inhale Therapeutic
Systems, Inc. as of December 31, 1999 and 1998, and the related statements of
operations, stockholders' equity and cash flows for each of the three years in
the period ended December 31, 1999. These financial statements are the
responsibility of the Company's management. Our responsibility is to express an
opinion on these financial statements based on our audits.

    We conducted our audits in accordance with auditing standards generally
accepted in the United States. Those standards require that we plan and perform
the audit to obtain reasonable assurance about whether the financial statements
are free of material misstatement. An audit includes examining, on a test basis,
evidence supporting the amounts and disclosures in the financial statements. An
audit also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.

    In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of Inhale Therapeutic Systems
at December 31, 1999 and 1998, and the results of its operations and its cash
flows for each of the three years in the period ended December 31, 1999 in
conformity with accounting principles generally accepted in the United States.

                                          /s/ ERNST & YOUNG LLP

Palo Alto, California
January 24, 2000

                                      F-2
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                                 BALANCE SHEETS

                        (IN THOUSANDS, EXCEPT PAR VALUE)

<TABLE>
<CAPTION>
                                                                 DECEMBER 31,
                                                              -------------------
                                                                1999       1998
                                                              --------   --------
<S>                                                           <C>        <C>
                                     ASSETS
Current assets:
  Cash and cash equivalents.................................  $ 33,430   $ 24,916
  Short-term investments....................................   104,755     57,946
  Accounts receivable.......................................     1,756      1,013
  Other current assets......................................     7,377        665
                                                              --------   --------
    Total current assets....................................   147,318     84,540
Property and equipment, net.................................    63,852     49,863
Investment in Alliance Pharmaceutical Corp..................     6,328         --
Other assets................................................     9,308         93
                                                              --------   --------
                                                              $226,806   $134,496
                                                              ========   ========

                      LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Accounts payable..........................................  $ 13,374   $  3,678
  Accrued liabilities.......................................     6,849      4,655
  Deferred revenue..........................................     4,811      4,359
  Tenant improvement loan--current portion..................        45         64
                                                              --------   --------
    Total current liabilities...............................    25,079     12,756
Tenant improvement loan.....................................     4,895      4,940
Convertible subordinated debentures.........................   108,450         --
Accrued rent................................................     1,753        919

Commitments (See Note 4)

Stockholders' equity:
  Preferred stock, 10,000 shares authorized, no shares
    issued or outstanding...................................        --         --
  Common stock, $0.0001 par value; 50,000 shares authorized;
    17,226 shares and 16,924 shares issued and outstanding
    at December 31, 1999 and 1998, respectively.............         2          2
  Capital in excess of par value............................   181,154    172,847
  Deferred compensation.....................................    (1,530)      (931)
  Accumulated deficit.......................................   (94,466)   (56,018)
  Accumulated other comprehensive gain/(loss)...............     1,469        (19)
                                                              --------   --------
    Total stockholders' equity..............................    86,629    115,881
                                                              --------   --------
                                                              $226,806   $134,496
                                                              ========   ========
</TABLE>

                             See accompanying notes

                                      F-3
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                            STATEMENTS OF OPERATIONS

                  (IN THOUSANDS, EXCEPT PER SHARE INFORMATION)

<TABLE>
<CAPTION>
                                                                 YEARS ENDED DECEMBER 31,
                                                              ------------------------------
                                                                1999       1998       1997
                                                              --------   --------   --------
<S>                                                           <C>        <C>        <C>
Contract research revenue...................................  $ 41,358   $ 21,795   $ 16,249
Operating costs and expenses:
  Research and development..................................    64,083     35,398     23,645
  General and administrative................................     7,869      8,387      6,328
  Acquired in-process research and development..............     9,890         --         --
                                                              --------   --------   --------
  Total operating costs and expenses........................    81,842     43,785     29,973
                                                              --------   --------   --------
Loss from operations........................................   (40,484)   (21,990)   (13,724)
Interest income.............................................     4,111      3,904      3,807
Interest expense............................................    (2,075)      (270)       (66)
                                                              --------   --------   --------
Net loss....................................................  $(38,448)  $(18,356)  $ (9,983)
                                                              ========   ========   ========
Basic and diluted net loss per share........................  $  (2.26)  $  (1.17)  $  (0.72)
                                                              ========   ========   ========
Shares used in computing basic and diluted net loss per
  share.....................................................    17,008     15,719     13,792
                                                              ========   ========   ========
</TABLE>

                             See accompanying notes

                                      F-4
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                       STATEMENT OF STOCKHOLDERS' EQUITY

                                 (IN THOUSANDS)

<TABLE>
<CAPTION>
                                                                                                    ACCUMULATED
                                   COMMON STOCK        CAPITAL IN                                      OTHER            TOTAL
                               ---------------------   EXCESS OF      DEFERRED      ACCUMULATED    COMPREHENSIVE    STOCKHOLDERS'
                                SHARES    PAR VALUE    PAR VALUE    COMPENSATION      DEFICIT       GAIN/(LOSS)        EQUITY
                               --------   ----------   ----------   -------------   ------------   --------------   -------------
<S>                            <C>        <C>          <C>          <C>             <C>            <C>              <C>
Balance at December 31,
  1996.......................   11,835    $      1      $ 62,839       $   (88)       $(27,679)        $  (12)        $ 35,061
Issuance of common stock in
  private placement, net of
  issuance costs of $1,940...    1,800           1        30,459            --              --             --           30,460
Issuance of common stock in
  connection with licensing
  agreement..................       28          --           600            --              --             --              600
Issuance of common stock in
  public offering, net of
  issuance costs of $2,885...    1,725          --        40,024            --              --             --           40,024
Common stock issued upon
  exercise of stock
  options....................      125          --           798            --              --             --              798
Issuance of common stock in
  connection with exercise of
  warrant....................       29          --            --            --              --             --               --
Deferred compensation........       --          --           551          (551)             --             --               --
Amortization of deferred
  compensation...............       --          --            --           101              --             --              101
Unrealized gain on
  available-for-sale
  securities.................       --          --            --            --              --             32               32
Net loss.....................       --          --            --            --          (9,983)            --           (9,983)
                                                                                                                      --------
Comprehensive loss...........       --          --            --            --              --             --           (9,951)
                                ------    ----------    --------       -------        --------         ------         --------
Balance at December 31,
  1997.......................   15,542           2       135,271          (538)        (37,662)            20           97,093
Issuance of common stock in
  private placement, net of
  issuance costs of $1,997...    1,200          --        35,202            --              --             --           35,202
Issuance of common stock and
  stock options in connection
  with licensing agreement...        6          --           284            --              --             --              284
Common stock issued upon
  exercise of stock
  options....................      176          --         1,514            --              --             --            1,514
Deferred compensation........       --          --           576          (576)             --             --               --
Amortization of deferred
  compensation...............       --          --            --           183              --             --              183
Unrealized loss on
  available-for-sale
  securities.................       --          --            --            --              --            (39)             (39)
Net loss.....................       --          --            --            --         (18,356)            --          (18,356)
                                                                                                                      --------
Comprehensive loss...........       --          --            --            --              --             --          (18,395)
                                ------    ----------    --------       -------        --------         ------         --------
Balance at December 31,
  1998.......................   16,924           2       172,847          (931)        (56,018)           (19)         115,881
Issuance of common stock to
  Alliance...................      180          --         5,000            --              --             --            5,000
Common stock issued upon
  exercise of stock options,
  net of costs...............      122          --         1,545            --              --             --            1,545
Compensation in connection
  with stock options granted
  to consultants.............       --          --           798            --              --             --              798
Deferred compensation........       --          --           964          (964)             --             --               --
Amortization of deferred
  compensation...............       --          --            --           365              --             --              365
Unrealized gain on
  available-for-sale
  securities.................       --          --            --            --              --          1,488            1,488
Net loss.....................       --          --            --            --         (38,448)            --          (38,448)
                                                                                                                      --------
Comprehensive loss...........       --          --            --            --              --             --          (36,960)
                                ------    ----------    --------       -------        --------         ------         --------
Balance at December 31,
  1999.......................   17,226    $      2      $181,154       $(1,530)       $(94,466)        $1,469         $ 86,629
                                ======    ==========    ========       =======        ========         ======         ========
</TABLE>

                             See accompanying notes

                                      F-5
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                            STATEMENTS OF CASH FLOWS

                INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS

                                 (IN THOUSANDS)

<TABLE>
<CAPTION>
                                                                  YEARS ENDED DECEMBER 31,
                                                              ---------------------------------
                                                                1999        1998        1997
                                                              ---------   ---------   ---------
<S>                                                           <C>         <C>         <C>
CASH FLOWS FROM (USED IN) OPERATING ACTIVITIES
Net loss....................................................  $ (38,448)  $ (18,356)  $  (9,983)
Adjustments to reconcile net loss to net cash used in
  operating activities:
  Depreciation and amortization.............................      6,889       3,415       2,337
  Amortization of deferred compensation.....................        365         183         101
  Issuance of common stock for services.....................        798          --          --
  Issuance of common stock and stock options in connection
    with licensing agreements...............................         --         284         600
  Acquired in-process research and development..............      9,890          --          --
Changes in assets and liabilities:
  Decrease (increase) in accounts receivable, other current
    assets, and other assets................................     (8,004)       (876)        518
  Increase (decrease) in accounts payable and accrued
    liabilities.............................................     12,724      (1,546)      7,443
  Increase (decrease) in deferred revenue...................        452      (2,327)      3,963
                                                              ---------   ---------   ---------
Net cash (used in) provided by operating activities.........    (15,334)    (19,223)      4,979
                                                              ---------   ---------   ---------
CASH FLOWS USED IN INVESTING ACTIVITIES
Acquisition of PulmoSpheres-Registered Trademark-
  technology................................................    (15,288)         --          --
Purchases of short-term investments.........................   (122,481)   (219,414)   (483,247)
Sales of short-term investments.............................     28,658      65,189      80,662
Maturities of short-term investments........................     47,174     182,309     334,289
Purchases of property and equipment, net....................    (20,502)    (34,584)    (17,261)
                                                              ---------   ---------   ---------
Net cash used in investing activities.......................    (82,439)     (6,500)    (85,557)
                                                              ---------   ---------   ---------
CASH FLOWS FROM FINANCING ACTIVITIES
Issuance of convertible subordinated debentures, net........    104,806          --          --
Payments of loan and capital lease and obligations..........        (64)       (181)       (168)
Proceeds from tenant improvement loan.......................         --          --       5,000
Issuance of common stock, net of issuance costs.............      1,545      36,716      71,282
                                                              ---------   ---------   ---------
Net cash provided by financing activities...................    106,287      36,535      76,114
                                                              ---------   ---------   ---------
Net increase (decrease) in cash and cash equivalents........      8,514      10,812      (4,464)
Cash and cash equivalents at beginning of year..............     24,916      14,104      18,568
                                                              ---------   ---------   ---------
Cash and cash equivalents at end of year....................  $  33,430   $  24,916   $  14,104
                                                              =========   =========   =========
</TABLE>

                             See accompanying notes

                                      F-6
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                         NOTES TO FINANCIAL STATEMENTS

                               DECEMBER 31, 1999

NOTE 1--ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

ORGANIZATION AND BASIS OF PRESENTATION

    Inhale Therapeutic Systems, Inc. ("Inhale", the "Company") was incorporated
in the State of California in July 1990 and reincorporated in the State of
Delaware in July 1998. Since inception, Inhale has been engaged in the
development of a system to deliver drugs to the bloodstream through the lungs by
inhaling a powdered version of the drug. The system is applicable to a wide
range of peptides, proteins and other molecules.

    Inhale expects increasing losses over the next several years as research and
development and manufacturing scale-up efforts continue, and as Inhale expands
its facilities for commercial manufacturing. Management plans to continue to
finance Inhale primarily through issuances of equity or debt securities,
research and development contract revenue, and in the longer term, revenue from
product sales and royalties.

    The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates.

CASH, CASH EQUIVALENTS AND INVESTMENTS

    Inhale considers all highly liquid investments with a maturity from date of
purchase of three months or less to be cash equivalents. Cash and cash
equivalents include demand deposits held in banks and interest bearing money
market funds. All other liquid investments are classified as short-term
investments. Short-term investments consist of federal and municipal government
securities, repurchase agreements or corporate commercial paper with A1 or P1
short-term ratings and A or better long-term ratings with remaining maturities
at date of purchase of greater than 90 days and less than one year. Inhale
limits its concentration of risk by diversifying its investments among a variety
of industries and issuers. Inhale has experienced no material losses on its
investments.

    At December 31, 1999, all short-term investments are designated as
available-for-sale and are carried at fair value, with material unrealized gains
and losses, if any, reported in stockholders' equity. The amortized cost of
securities is adjusted for amortization of material premiums and accretion of
discounts to maturity. Such amortization, if any, is included in interest
income. Realized gains and losses and declines in value judged to be
other-than-temporary on available-for-sale securities, if any, are included in
interest income. The cost of securities sold is based on the specific
identification method. Interest and dividends on securities classified as
available-for-sale are included in interest income.

                                      F-7
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 1--ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    The following is a summary of available-for-sale debt securities as of
December 31, 1999:

<TABLE>
<CAPTION>
                                                            AVAILABLE-FOR-SALE DEBT SECURITIES
                                                      -----------------------------------------------
                                                                   GROSS        GROSS
                                                                 UNREALIZED   UNREALIZED   ESTIMATED
                                                        COST       GAINS        LOSSES     FAIR VALUE
                                                      --------   ----------   ----------   ----------
                                                                      (IN THOUSANDS)
<S>                                                   <C>        <C>          <C>          <C>
Obligations of U.S. government agencies.............  $ 81,692      $108      $      --     $ 81,800
U.S. corporate commercial paper.....................    41,081        33             --       41,114
Repurchase agreements, secured by U.S. Government
  securities........................................     3,845        --             --        3,845
Other...............................................     7,872        --             --        7,872
                                                      --------      ----      ---------     --------
                                                      $134,490      $141      $      --     $134,631
                                                      ========      ====      =========     ========
Amounts included in cash and cash equivalents.......  $ 29,822      $ 54      $      --     $ 29,876
Amounts included in short-term investments..........   104,668        87             --      104,755
                                                      --------      ----      ---------     --------
                                                      $134,490      $141      $      --     $134,631
                                                      ========      ====      =========     ========
</TABLE>

    The following is a summary of available-for-sale debt securities as of
December 31, 1998:

<TABLE>
<CAPTION>
                                                             AVAILABLE-FOR-SALE DEBT SECURITIES
                                                       -----------------------------------------------
                                                                    GROSS        GROSS
                                                                  UNREALIZED   UNREALIZED   ESTIMATED
                                                         COST       GAINS        LOSSES     FAIR VALUE
                                                       --------   ----------   ----------   ----------
                                                                       (IN THOUSANDS)
<S>                                                    <C>        <C>          <C>          <C>
Obligations of U.S. government agencies..............  $20,758    $      --       $ --       $ 20,758
U.S. corporate commercial paper......................   42,773           --        (19)        42,754
Repurchase agreements, secured by U.S. Government
  securities.........................................   17,704           --         --         17,704
Other................................................      105           --         --            105
                                                       -------    ---------       ----       --------
                                                       $81,340    $      --       $(19)      $ 81,321
                                                       =======    =========       ====       ========
Amounts included in cash and cash equivalents........  $23,375    $      --       $ --       $ 23,375
Amounts included in short-term investments...........   57,965           --        (19)        57,946
                                                       -------    ---------       ----       --------
                                                       $81,340    $      --       $(19)      $ 81,321
                                                       =======    =========       ====       ========
</TABLE>

    The gross realized losses and gains on the sale of debt securities
available-for-sale during the years ended December 31, 1999 and 1998 were not
material. At December 31, 1999 and 1998, the average portfolio duration was
approximately five months and three months, respectively, and the contractual
maturity of any single investment did not exceed eleven months at December 31,
1999 and 1998.

    The estimated fair value amounts have been determined by Inhale using
available market information and appropriate valuation methodologies. However,
market data must be interpreted to develop the estimates of fair value.
Accordingly, the estimates presented herein are not necessarily indicative of
the amounts that Inhale could realize in a current market exchange.

                                      F-8
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 1--ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    Inhale owns common stock in one technology company. These shares of Alliance
Pharmaceutical Corp. ("Alliance") are accounted for as long-term
available-for-sale securities. Due to restrictions on the sale of this stock,
the Company carries that portion of its investment in Alliance that can be sold
within one year at market value, with material unrealized gains and losses, if
any, reported in stockholders' equity. That portion which cannot be sold within
one year is carried at cost.

PROPERTY AND EQUIPMENT

    Property and equipment consist of the following at December 31:

<TABLE>
<CAPTION>
                                                             1999       1998
                                                           --------   --------
                                                             (IN THOUSANDS)
<S>                                                        <C>        <C>
Laboratory and other equipment...........................  $ 24,317   $15,012
Leasehold improvements...................................    47,101    36,003
Land.....................................................     7,443     7,443
                                                           --------   -------
                                                             78,861    58,458
Less accumulated depreciation............................   (15,009)   (8,595)
                                                           --------   -------
                                                           $ 63,852   $49,863
                                                           ========   =======
</TABLE>

    Property and equipment are stated at cost. Major renewals and improvements
are capitalized, while maintenance and repairs are expensed when incurred. Other
equipment is depreciated using the straight-line method over estimated useful
lives of four to seven years. Manufacturing equipment is depreciated using the
straight-line method over its useful life estimated to be ten years. Leasehold
improvements and assets acquired under capital leases are amortized using the
straight-line method over the shorter of an estimated useful life of fifteen
years or the term of the lease.

    Interest is capitalized in connection with the construction of leasehold
improvements to the Company's manufacturing facility in San Carlos, California.
The capitalized interest is recorded as part of the asset to which it relates
and is amortized over the asset's estimated useful life. In 1999 and 1998,
Inhale capitalized $0 and $203,000 of interest cost, respectively.

COMPREHENSIVE GAIN/LOSS

    Effective January 1, 1998, Inhale adopted the Financial Accounting Standards
Board's ("FASB") Statement of Financial Accounting Standards No. 130, "Reporting
Comprehensive Income" ("SFAS 130"). The Company's other component of
comprehensive gain/loss includes only unrealized gains and losses on securities
held as available-for-sale and is shown in the Statement of Stockholders'
Equity. Inhale has no other material components of other comprehensive loss and
accordingly the comprehensive loss is the same as net loss for all periods.

REVENUE RECOGNITION

    Contract revenue from collaborative research agreements is recorded when
earned and as the related costs are incurred. Payments received which are
related to future performance are deferred and recognized as revenue when earned
over future performance periods. In accordance with contract terms, upfront and

                                      F-9
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 1--ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
milestone payments from collaborative research agreements are considered
reimbursements for costs incurred under the agreements, and accordingly, are
generally recognized based on actual efforts expended over the remaining terms
of the agreements. Inhale's research revenue is derived primarily from clients
in the pharmaceutical industry. Contract research revenue from three partners
represented 71%, 10% and 9% of Inhale's revenue in 1999. Three partners
accounted for 51%, 22% and 18% of Inhale's revenue in 1998 and 47%, 25% and 21%
of Inhale's revenue in 1997. Costs of contract research revenue approximate such
revenue and are included in research and development expenses.

STOCK-BASED COMPENSATION

    As permitted by the provisions of Statement of Financial Accounting
Standards No. 123, "Accounting for Stock-Based Compensation" ("FAS 123"), Inhale
continues to follow Accounting Principles Board Opinion No. 25, "Accounting for
Stock Issued to Employees" ("APB 25") and related interpretations in accounting
for its employee stock option plans. Under APB 25, if the exercise price of
Inhale's employee stock options equals or exceeds the fair market value of the
underlying stock on the date of grant as determined by the closing price of
Inhale's common stock as quoted on the Nasdaq stock market, no compensation
expense is recognized. See Note 5 for pro forma disclosures required by
FAS 123.

RESEARCH AND DEVELOPMENT AGREEMENTS

    Inhale performs research and development for others pursuant to feasibility
agreements and development and license agreements. Under the feasibility
agreements, Inhale generally is reimbursed for the cost of work performed.
Feasibility agreements are designed to evaluate the applicability of Inhale's
technologies to a particular molecule and therefore are generally completed in
less than one year. Under Inhale's development and license agreements, the
partner companies receive an exclusive license to develop, use and sell a dry
powder formulation and a suitable delivery device to be developed by Inhale for
one of the partner's macromolecule drugs. Under these development agreements,
Inhale will be reimbursed for development costs and may also be entitled to
milestone payments when and if certain development milestones are achieved. All
of Inhale's research and development agreements are generally cancelable by the
partner without significant financial penalty to the partner.

ACCOUNTING FOR INCOME TAXES

    Inhale accounts for income taxes under Statement of Financial Accounting
Standards No. 109, "Accounting for Income Taxes" ("FAS 109"). Under FAS 109, the
liability method is used in accounting for income taxes.

                                      F-10
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 1--ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

NET LOSS PER SHARE

    In accordance with Financial Accounting Standard No. 128, basic and diluted
net loss per share has been computed using the weighted average number of shares
of common stock outstanding during the period. Had Inhale been in a net income
position, diluted earnings per share would have included the following
outstanding options, warrants and convertible debentures:

<TABLE>
<CAPTION>
                                                                 YEARS ENDED DECEMBER 31,
                                                           ------------------------------------
                                                             1999          1998          1997
                                                           --------      --------      --------
                                                                      (IN THOUSANDS)
<S>                                                        <C>           <C>           <C>
Warrants.............................................          20            20            20
Options..............................................       4,553         3,163         2,351
Convertible debentures...............................       3,388            --            --
                                                            -----         -----         -----
  Total..............................................       7,961         3,183         2,371
                                                            =====         =====         =====
</TABLE>

SEGMENT INFORMATION

    Effective January 1, 1998, Inhale adopted the FASB's Statement of Financial
Accounting Standards No. 131, "Disclosures about Segments of an Enterprise and
Related Information" ("SFAS 131"). SFAS 131 superseded FASB Statement No. 14,
"Financial Reporting for Segments of a Business Enterprise." SFAS 131
establishes standards for the way that public business enterprises report
information about operating segments in annual financial statements and requires
that those enterprises report selected information about operating segments in
interim financial reports. SFAS 131 also establishes standards for related
disclosures about products and services, geographic areas, and major customers.

    Management has organized Inhale's business in one operating segment which
includes activities related to the development of systems for the pulmonary
delivery of macromolecule drugs. Inhale's operations and all of its assets are
presently located in the United States and the Company derives all of its
revenues within the United States.

RECLASSIFICATION

    Certain prior year amounts have been reclassified to conform to the 1999
presentation.

NOTE 2--COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENTS

    Inhale performs research and development for others pursuant to feasibility
agreements and development and license agreements. Under the feasibility
agreements, Inhale generally is reimbursed for the cost of work performed.
Feasibility agreements are designed to evaluate the applicability of Inhale's
technologies to a particular molecule and therefore are generally completed in
less than one year. Under Inhale's development and license agreements, the
partner companies receive an exclusive license to develop, use and sell a dry
powder formulation and a suitable delivery device to be developed by Inhale for
one of the partner's macromolecule drugs. Under these development agreements,
Inhale will be reimbursed for development costs and may also be entitled to
milestone payments when and if certain development milestones are achieved. All
of Inhale's research and development agreements are generally cancelable by the
partner without significant financial penalty to the partner.

                                      F-11
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 2--COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENTS (CONTINUED)
    In February 1999, Inhale entered into a collaborative agreement with Biogen
to develop pulmonary delivery for Biogen's AVONEX-Registered Trademark-, a drug
used in the treatment of Multiple Sclerosis. Under the terms of the agreement,
Inhale will receive royalties on product sales, an up-front signing fee, and up
to an estimated $25 million in research and development funding and potential
progress payments. Biogen will provide bulk AVONEX-Registered Trademark- to
Inhale for formulation into a dry powder which is stable at room temperature.
Inhale will manufacture and package the dry powder and supply inhalation
devices. Biogen will be responsible for clinical trials, marketing and
commercialization. The Company recognized revenue of $2.2 million under this
agreement in 1999.

    In December 1997, the Company entered into a collaboration agreement with
Eli Lilly and Company ("Lilly") to develop pulmonary delivery for an undisclosed
protein based on Inhale's deep-lung drug delivery system for macromolecules.
Under the terms of the agreement, Inhale will receive funding of up to
$20 million in research, development and progress payments. Lilly will receive
global commercialization rights for the pulmonary delivery of the products with
Inhale receiving royalties on any marketed products. Inhale will manufacture
packaged powders for and supply devices to Lilly. Under this agreement the
Company recognized revenue of $1.2 million in 1999 and $0.9 million in 1998. No
revenue was recognized under this agreement in 1997.

    In January 1997, the Company executed a collaboration agreement with Lilly
to develop pulmonary delivery for parathyroid hormone ("PTH"). Under the terms
of the agreement, Inhale will receive funding of up to $20 million of initial
fees, research and development and progress payments. Lilly will receive global
commercialization rights for the pulmonary delivery of the products with Inhale
receiving royalties on any marketed products. Inhale will manufacture packaged
powders for and supply devices to Lilly. Under this agreement, the Company
recognized revenue of $3.8 million and $3.4 million in 1998 and 1997,
respectively. In late 1998, unexpected observations from a long-term test in
rats of the injectable version of parathyroid hormone led Lilly to suspend
further clinical development of the injectable and pulmonary versions of PTH
pending further analysis. Inhale is maintaining a minimum development effort in
its pulmonary program pending further direction from Lilly. Inhale does not
currently believe that the program will be reinitiated in the near future, if at
all.

    In December 1996, Inhale entered into a collaborative agreement with Aventis
Behring to develop a pulmonary formulation of alpha-1 proteinase inhibitor to
treat patients with alpha-1 antitrypsin deficiency, or genetic emphysema. Under
the terms of the collaboration, Aventis Behring will receive commercialization
rights worldwide excluding Japan and Inhale will receive royalties on product
sales, an up-front signing fee and up to an estimated $15 million in research
and development funding and milestone payments. Aventis Behring will manufacture
the active ingredient for use in Inhale's delivery device. Inhale will
manufacture and package the dry powder and supply inhalation devices to Aventis
Behring for commercialization and marketing. Under this agreement, the Company
recognized revenue of $3.9 million, $1.6 million and $0.9 million in 1999, 1998
and 1997, respectively.

    In March 1996, Inhale entered into a collaboration agreement with Baxter
Healthcare Corporation ("Baxter") to use Inhale's dry powder pulmonary delivery
system as a technology platform for developing and launching therapeutic
products. In connection with the collaboration, Baxter made a $20 million equity
investment in Inhale at a 25% premium to the market price of Inhale stock at the
time of the investment. Baxter received worldwide commercialization rights in
exchange for up to an estimated

                                      F-12
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 2--COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENTS (CONTINUED)
$60 million in research and development funding and milestone payments for four
molecules. In October 1998, Inhale announced that it had reached an agreement
with Baxter to amend their collaborative agreement to facilitate signing a new
corporate partner to fund further development and commercialization of the
undisclosed compound that had been their focus since April, 1998. Baxter's
obligations under this amendment expired in September, 1999. As a result, rights
to the compounds reverted to Inhale and are now available for other partnering
opportunities. The Company recognized revenues associated with this program of
$4.3 million, $4.0 million and $4.1 million in 1999, 1998, and 1997,
respectively.

    In January 1995, the Company entered into a collaborative development and
license agreement with Pfizer Inc. ("Pfizer") to develop pulmonary delivery for
inhaled insulin based on Inhale's deep-lung delivery system for macromolecules.
Under the terms of the agreement, Inhale will receive funding consisting of
initial fees, research and development and progress payments. Upon execution of
the agreement Pfizer purchased $5.0 million of Inhale common stock. In addition,
in October 1996, Pfizer purchased an additional $5.0 million of Inhale common
stock. Pfizer will receive global commercialization rights for the pulmonary
delivery of the products with Inhale receiving royalties on any marketed
products. Inhale will manufacture inhaled insulin for, and supply devices to
Pfizer. Under this agreement the Company recognized revenue of $29.5 million,
$11.1 million and $7.6 million in 1999, 1998 and 1997, respectively.

    Costs associated with research and development activities attributable to
these agreements are expected to approximate the revenues recognized.

NOTE 3--ACQUISITION OF PULMOSPHERES-REGISTERED TRADEMARK- TECHNOLOGY

    In November 1999, Inhale concluded an agreement with Alliance Pharmaceutical
Corp. to acquire Alliance's PulmoSpheres-Registered Trademark- particle and
particle processing technology for use in respiratory drug delivery. Under the
terms of the agreement, Inhale received the rights to
PulmoSpheres-Registered Trademark- technology, other related assets and Alliance
stock valued at $5 million in exchange for $15 million in cash and $5 million of
Inhale stock. The purchase price, including $387,000 of acquisition costs, has
been allocated to assets acquired and to in-process research and development,
which has been charged as an expense on the Statement of Operations for the year
ended December 31, 1999. The Company's investment in Alliance and the assets
acquired in connection with the PulmoSpheres-Registered Trademark- acquisition
are recorded at their fair market value at acquisition as follows:

<TABLE>
<S>                                                           <C>
Property and equipment, net.................................  $   200
Acquired in-process research and development charged to
  operations at December 31, 1999...........................    9,890
Intellectual property, net..................................    3,171
Assembled workforce.........................................       96
Goodwill....................................................    2,030
                                                              -------
  Total cash purchase consideration.........................   15,387
Common stock of Alliance....................................    5,000
                                                              -------
  Total purchase consideration..............................  $20,387
                                                              =======
</TABLE>

                                      F-13
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 3--ACQUISITION OF PULMOSPHERES-REGISTERED TRADEMARK- TECHNOLOGY (CONTINUED)
Goodwill and other intangible assets are being amortized over seven years.

    The purchased research and development was identified and valued through
extensive interviews and discussions with appropriate management and scientific
personnel and the analysis of data provided by Alliance regarding the
PulmoSpheres-Registered Trademark- technology, its stage of development at the
time of acquisition, the importance of the technology to Inhale's overall
development plan, and the projected incremental cash flows from the projects
when completed and any associated risks. Associated risks include the
uncertainties in overcoming significant technological risks, acquiring FDA
approval and establishing commercial viability.

NOTE 4--COMMITMENTS, LONG-TERM DEBT AND TENANT IMPROVEMENT LOAN

    As of December 31, 1999, Inhale had $108,450,000 aggregate principal amount
of 6 3/4% Convertible Subordinated Debentures ("the Debentures") which will
mature on October 13, 2006 and are convertible into shares of Inhale's common
stock at a conversion price of $32.0075 per share, subject to adjustment in
certain circumstances. The Debentures are redeemable in part or in all at the
option of the Company on or after October 13, 2002. Interest is payable
semi-annually on April 13 and October 13. The Debentures are unsecured
subordinated obligations which rank junior in right of payment to all of the
Company's existing and future Senior Debt. The Company had approximately
$4.9 million of Senior Debt outstanding at December 31, 1999. Costs relating to
the issuance of the Debentures are recorded as long-term assets and are being
amortized over the term of the debt (see Note 8).

    Inhale leases its office and laboratory facilities under several
arrangements expiring through the year 2012. Rent expense was approximately
$2,484,000, $1,777,000 and $1,106,000 for the years ended December 31, 1999,
1998 and 1997, respectively. In November 1997, Inhale received from the landlord
of its facility in San Carlos, California a loan of $5.0 million to fund a
portion of the cost of improvements made to the facility. The loan bears
interest at 9.46% per annum, and principal and interest payments are payable
monthly over the ten-year loan term with a balloon payment of $4.5 million at
the end of the tenth year. The loan is recorded on the balance sheet as a tenant
improvement loan.

                                      F-14
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 4--COMMITMENTS, LONG-TERM DEBT AND TENANT IMPROVEMENT LOAN (CONTINUED)
    Future noncancelable commitments under operating leases and the tenant
improvement loan at December 31, 1999 are as follows:

<TABLE>
<CAPTION>
                                                                       TENANT
                                                         OPERATING   IMPROVEMENT
                                                          LEASES        LOAN
                                                         ---------   -----------
                                                             (IN THOUSANDS)
<S>                                                      <C>         <C>
Years ending December 31,
  2000.................................................   $ 1,841      $   510
  2001.................................................     2,028          503
  2002.................................................     2,136          503
  2003.................................................     1,792          503
  2004.................................................     1,713          503
  2005 and thereafter..................................    14,484        5,974
                                                          -------      -------
Total minimum payments required........................   $23,994      $ 8,496
                                                          =======      -------
Less amount representing interest......................                 (3,556)
                                                                       -------
Present value of future payments.......................                  4,940
Less current portion...................................                    (45)
                                                                       -------
Non-current portion....................................                $ 4,895
                                                                       =======
</TABLE>

NOTE 5--STOCKHOLDERS' EQUITY

COMMON STOCK

EMPLOYEE STOCK PURCHASE PLAN

    In February 1994, Inhale's Board of Directors adopted the Employee Stock
Purchase Plan (the "Purchase Plan"). Under the Purchase Plan, 150,000 shares of
common stock have been reserved for purchase by Inhale's employees pursuant to
section 423(b) of the Internal Revenue Code of 1986. As of December 31, 1999, no
shares of common stock have been issued under the Purchase Plan.

STOCK OPTION PLANS

EQUITY INCENTIVE PLAN

    Inhale's 1994 Equity Incentive Plan (the "Equity Incentive Plan") was
adopted by the Board of Directors in February 1994. The Equity Incentive Plan is
an amendment and restatement of Inhale's 1992 Stock Option Plan. The purpose of
the Equity Incentive Plan is to attract and retain qualified personnel, to
provide additional incentives to employees, officers, consultants and employee
directors of Inhale and to promote the success of Inhale's business. Pursuant to
the Equity Incentive Plan, Inhale may grant or issue incentive stock options to
employees and officers and non-qualified stock options, restricted stock
purchase awards, stock bonuses and stock appreciation rights to consultants,
employees, officers and employee directors. Options granted to non-employees are
recorded at fair value based on the fair value measurement criteria of FAS 123.

                                      F-15
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 5--STOCKHOLDERS' EQUITY (CONTINUED)

    The maximum term of a stock option under the Equity Incentive Plan is ten
years, but if the optionee at the time of grant has voting power of more than
10% of Inhale's outstanding capital stock, the maximum term of an incentive
stock option is five years. The exercise price of incentive stock options
granted under the Equity Incentive Plan must be at least equal to 100% (or 110%
with respect to holders of more than 10% of the voting power of Inhale's
outstanding capital stock) of the fair market value of the stock subject to the
option on the date of the grant. The exercise price of non-qualified stock
options, and the purchase price of restricted stock purchase awards, granted
under the Equity Incentive Plan are determined by the Board of Directors. Stock
appreciation rights authorized for issuance under the Equity Incentive Plan may
be tandem stock appreciation rights, concurrent stock appreciation rights or
independent stock appreciation rights.

    The Equity Incentive Plan may be amended at any time by the Board, although
certain amendments would require shareholder approval. The Equity Incentive Plan
will terminate in February 2004 unless earlier terminated by the Board.

NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

    In February 1994, Inhale's Board of Directors adopted the Non-employee
Directors' Stock Option Plan under which options to purchase up to 200,000
shares of Inhale's common stock at the then fair market value may be granted to
Inhale's non-employee directors. As of December 31, 1999, options on 34,800
shares had been exercised and options to purchase 102,066 shares were
exercisable.

1998 NON-OFFICER EQUITY INCENTIVE PLAN

    Inhale's 1998 Non-officer Equity Incentive Plan ("1998 Plan") was adopted by
the Board of Directors in June 1998. The purpose of the 1998 Plan is to attract
and retain qualified personnel, to provide additional incentives to employees
and consultants and to promote the success of Inhale's business. Pursuant to the
1998 plan, Inhale may grant or issue non-qualified stock options, restricted
stock purchase awards, stock bonuses and stock appreciation rights to employees
and consultants who are neither Officers or Directors of Inhale.

    The maximum term of a stock option under the 1998 Plan is ten years. The
exercise price of stock options, and the purchase price of restricted stock
purchase awards granted under the 1998 Plan are determined by the Board of
Directors. Stock appreciation rights authorized for issuance under the 1998 Plan
may be tandem stock appreciation rights, concurrent stock appreciation rights or
independent stock appreciation rights. The 1998 Non-officer Equity Incentive
Plan may be amended by the Board of Directors at any time.

                                      F-16
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 5--STOCKHOLDERS' EQUITY (CONTINUED)
    A summary of activity under the Equity Incentive Plan, the Non-Employee
Directors' Stock Option Plan and the 1998 Non-officer Equity Incentive Plan is
as follows:

<TABLE>
<CAPTION>
                                                               OPTIONS OUTSTANDING
                                                        ---------------------------------   WEIGHTED-AVERAGE
                                    OPTIONS AVAILABLE                      EXERCISE PRICE    EXERCISE PRICE
                                        FOR GRANT       NUMBER OF SHARES     PER SHARE         PER SHARE
                                    -----------------   ----------------   --------------   ----------------
                                                  (IN THOUSANDS, EXCEPT PER SHARE INFORMATION)
<S>                                 <C>                 <C>                <C>              <C>
Balance at December 31, 1996......         1,774             1,659          $ 0.06-19.25         $ 9.13
  Options granted.................          (851)              851            0.01-35.25          21.01
  Options exercised...............            --              (125)           0.06-16.13           6.41
  Options canceled................            34               (34)           0.56-22.75          15.43
                                          ------             -----          ------------         ------
Balance at December 31, 1997......           957             2,351            0.01-35.25          13.48
  Shares authorized...............         1,550                --                    --             --
  Options granted.................        (1,069)            1,069            0.01-34.13          28.16
  Options exercised...............            --              (174)           0.06-22.75           8.69
  Options canceled................            83               (83)           5.56-35.25          21.89
                                          ------             -----          ------------         ------
Balance at December 31, 1998......         1,521             3,163            0.01-35.25          18.48
  Shares authorized...............         1,250                --                    --             --
  Options granted.................        (1,575)            1,575            0.01-41.88          27.15
  Options exercised...............            --              (124)           0.01-34.12          12.60
  Options canceled................            61               (61)          10.01-34.12          26.46
                                          ------             -----          ------------         ------
Balance at December 31, 1999......         1,257             4,553            0.01-41.88         $21.52
                                          ======             =====          ============         ======
</TABLE>

    At December 31, 1999, 1998 and 1997, options were exercisable to purchase
approximately 1,511,484, 1,077,000 and 784,000 at weighted-average exercise
prices of $14.91, $11.36 and $8.17 per share, respectively.

    Weighted average fair value of options granted during the year ended
December 31, 1999, 1998 and 1997, was $28.34, $28.42 and $21.89, respectively.
The following table provides information regarding Inhale's stock option plans
as of December 31, 1999.

<TABLE>
<CAPTION>
                                        OPTIONS OUTSTANDING                           OPTIONS EXERCISABLE
                        ----------------------------------------------------   ---------------------------------
                                                               WEIGHTED-
                                                                AVERAGE
                                            WEIGHTED-          REMAINING                           WEIGHTED-
      RANGE OF                           AVERAGE EXERCISE   CONTRACTUAL LIFE                    AVERAGE EXERCISE
   EXERCISE PRICES          NUMBER       PRICE PER SHARE       (IN YEARS)          NUMBER       PRICE PER SHARE
- ---------------------   --------------   ----------------   ----------------   --------------   ----------------
                        (IN THOUSANDS)                                         (IN THOUSANDS)
<S>                     <C>              <C>                <C>                <C>              <C>
    $  0.01-7.75              595             $ 3.82              5.03               496             $ 4.42
      8.88-12.00              454              10.09              5.60               272              10.12
     14.25-19.63              743              17.55              6.90               299              16.92
     21.88-32.38            2,655              28.01               9.0               409              27.66
     34.13-41.88              106              35.19              8.10                35              34.83
    ------------            -----             ------              ----             -----             ------
    $ 0.01-41.88            4,553             $21.52              7.80             1,511             $14.91
    ============            =====             ======              ====             =====             ======
</TABLE>

                                      F-17
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 5--STOCKHOLDERS' EQUITY (CONTINUED)
    In 1999, the Company granted 67,100 options to employees and consultants
with exercise prices below the market price of the stock on the grant date. The
weighted-average exercise price and weighted-average fair value of these options
as of December 31, 1999 were $0.01 and $27.87, respectively.

    Pro forma information regarding net income and earnings per share is
required by FAS 123, which also requires that the information be determined as
if Inhale has accounted for its employee stock options granted subsequent to
December 31, 1994 under the fair value method of that Statement. The fair value
for these options was estimated at the date of grant using a Black-Scholes
option pricing model with the following weighted-average assumptions:

<TABLE>
<CAPTION>
                                                       1999          1998          1997
                                                     --------      --------      --------
<S>                                                  <C>           <C>           <C>
Risk-free interest rate........................       5.6%          4.8%          5.7%
Dividend yield.................................       0.0%          0.0%          0.0%
Volatility factor..............................        0.600         0.700         0.578
Weighted average expected life.................      5 years       5 years       6 years
</TABLE>

    The Black-Scholes options valuation model was developed for use in
estimating the fair value of traded options which have no vesting restrictions
and are fully transferable. In addition, option valuation models require the
input of highly subjective assumptions including the expected stock price
volatility. Because Inhale's employee stock options have characteristics
significantly different from those of traded options, and because changes in the
subjective input assumptions can materially affect the fair value estimate, in
management's opinion, the existing models do not necessarily provide a reliable
single measure of the fair value of its employee stock options. However, Inhale
has presented the pro forma net loss and pro forma basic and diluted net loss
per common share using the assumptions noted above.

    For purposes of pro forma disclosures, the estimated fair value of the
options is amortized to expense over the options' vesting period, generally five
years. Inhale's pro forma information follows (in thousands except for earnings
per share):

<TABLE>
<CAPTION>
                                                    YEARS ENDED DECEMBER 31,
                                                 ------------------------------
                                                   1999       1998       1997
                                                 --------   --------   --------
<S>                                              <C>        <C>        <C>
Pro forma net loss.............................  $(48,077)  $(24,325)  $(13,168)
                                                 ========   ========   ========
Pro forma basic and diluted net loss per common
  share........................................  $  (2.83)  $  (1.55)  $  (0.95)
                                                 ========   ========   ========
</TABLE>

Because FAS 123 is applicable only to options granted subsequent to
December 31, 1994, the pro forma effect of the statement will not be fully
reflected until approximately the year 2000.

WARRANTS

    In October 1996 Inhale issued two warrants ("the warrants") to purchase a
total of 20,000 shares of Common Stock (10,000 shares each) at a price of
$13.125 per share in connection with a facility lease. The warrants expire in
October 2006 and were both outstanding and exercisable at December 31, 1999.

                                      F-18
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 5--STOCKHOLDERS' EQUITY (CONTINUED)
STOCK COMPENSATION

    Inhale recorded deferred compensation of approximately $964,000 during the
year ended December 31, 1999. Deferred compensation of $576,000 had been
recorded in the year ended December 31, 1998. These amounts represent the
difference between the exercise price and the deemed fair market value of
certain of Inhale's stock options granted in these periods and are being
amortized to expense over the three-year vesting period of the options.

RESERVED SHARES

    A total of 5,830,108 shares of common stock have been reserved for issuance
at December 31, 1999 for Inhale's equity incentive plans and the warrants.

NOTE 6--INCOME TAXES

    As of December 31, 1999, Inhale had federal and state net operating loss
carryforwards of approximately $82,000,000 and $10,600,000, respectively. Inhale
also had federal and state research and other tax credit carryforwards of
approximately $2,000,000 and $2,100,000, respectively. The federal and state net
operating loss and credit carryforwards will expire at various dates beginning
in 2000 through 2019 if not utilized.

    Utilization of the federal and state net operating loss and credit
carryforwards may be subject to a substantial annual limitation due to the
"change in ownership" provisions of the Internal Revenue Code of 1986 and
similar state provisions. The annual limitation may result in the expiration of
net operating losses and credits before utilization.

    Significant components of Inhale's deferred tax assets for federal and state
income taxes as of December 31 are as follows:

<TABLE>
<CAPTION>
                                                            1999       1998
                                                          --------   --------
                                                            (IN THOUSANDS)
<S>                                                       <C>        <C>
Deferred tax assets:
  Net operating loss carryforwards......................  $ 28,500   $ 16,300
  Research and other credits............................     3,700      2,200
  Capitalized research expenses.........................     1,600      1,900
  Deferred revenue......................................     1,900      1,700
  Depreciation..........................................     1,300         --
  Other.................................................     2,100      2,500
                                                          --------   --------
Total deferred tax assets...............................    39,100     24,600
Valuation allowance for deferred tax assets.............   (39,100)   (24,600)
                                                          --------   --------
Net deferred tax assets.................................  $     --   $     --
                                                          ========   ========
</TABLE>

    Because of Inhale's lack of earnings history, the deferred tax assets have
been fully offset by a valuation allowance. The valuation allowance increased by
$14,500,000 and $8,900,000 during the years ended December 31, 1999 and 1998,
respectively.

                                      F-19
<PAGE>
                        INHALE THERAPEUTIC SYSTEMS, INC.

                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)

                               DECEMBER 31, 1999

NOTE 7--STATEMENT OF CASH FLOWS DATA

<TABLE>
<CAPTION>
                                                                       YEARS ENDED
                                                                       DECEMBER 31,
                                                              ------------------------------
                                                                1999       1998       1997
                                                              --------   --------   --------
                                                                      (IN THOUSANDS)
<S>                                                           <C>        <C>        <C>
Supplemental disclosure of cash flows information:
  Interest paid.............................................   $  470      $270       $ 66
                                                               ======      ====       ====
Supplemental schedule of non-cash investing and financing
  activities:
  Deferred compensation related to the issuance of certain
    stock options...........................................   $  964      $576       $551
                                                               ======      ====       ====
  Issuance of common stock to Alliance......................   $5,000      $ --       $ --
                                                               ======      ====       ====
  Issuance of common stock and options in connection with
    licensing agreement.....................................   $   --      $284       $600
                                                               ======      ====       ====
</TABLE>

NOTE 8--SUBSEQUENT EVENTS (UNAUDITED)

    In February 2000, Inhale received $222.4 million in net proceeds from the
issuance of $230.0 million aggregate principal amount of convertible
subordinated notes to certain qualified institutional buyers under Rule 144A of
the Securities Act of 1933, as amended. Interest on the notes accrues at a rate
of 5% per year, subject to adjustment in certain circumstances. The notes will
mature in 2007 and are convertible into shares of Inhale's common stock at a
conversion price of $76.71 per share, subject to adjustment in certain
circumstances.

    In February 2000, Inhale entered into privately negotiated agreements with
certain holders of its outstanding 6 3/4% convertible subordinated debentures
privately placed in October and November 1999, providing for the conversion of
approximately $94.2 million aggregate principal amount of the outstanding
debentures in exchange for cash payments of approximately $16.2 million in the
aggregate. As a result of these transactions, the $94.2 million of convertible
debentures were converted into approximately 2.9 million shares of Inhale common
stock. Inhale will no longer have interest payment obligations on the debentures
that were converted.

                                      F-20

<PAGE>

                                                                    Exhibit 4.11

                        INHALE THERAPEUTIC SYSTEMS, INC.
                            (a Delaware corporation)


                                  $200,000,000
                  5.00% Convertible Subordinated Notes due 2007


                               PURCHASE AGREEMENT

                                                                February 2, 2000

MERRILL LYNCH & CO.
Merrill Lynch, Pierce, Fenner & Smith
                Incorporated
Deutsche Bank Securities Inc.
Lehman Brothers Inc.
U.S. Bancorp Piper Jaffray Inc.
c/o Merrill Lynch & Co.
North Tower
World Financial Center
New York, New York 10281-1209

Ladies and Gentlemen:

         Inhale Therapeutic Systems, Inc., a Delaware corporation (the
"Company"), confirms its agreement with Merrill Lynch & Co., Merrill Lynch,
Pierce, Fenner & Smith Incorporated ("Merrill Lynch") and each of the other
Initial Purchasers named in SCHEDULE A hereto (collectively, the "Initial
Purchasers", which term shall also include any initial purchaser substituted as
hereinafter provided in Section 11 hereof), for whom Merrill Lynch and Deutsche
Bank Securities Inc. are acting as representatives (in such capacity, the
"Representatives"), with respect to the issue and sale by the Company and the
purchase by the Initial Purchasers, acting severally and not jointly, of the
respective principal amounts set forth in said SCHEDULE I of $200,000,000
aggregate principal amount of the Company's 5.00% Convertible Subordinated Notes
due 2007 (the "Firm Notes"), and with respect to the grant by the Company to the
Initial Purchasers, acting severally and not jointly, of the option described in
Section 2(b) hereof (the "Option") to purchase all or any part of an additional
$30,000,000 principal amount of the Company's 5.00% Convertible Subordinated
Notes due 2007 to cover over-allotments, if any (the "Optional Notes" and,
together with the Firm Notes, the "Notes").

         The Notes will be convertible into fully paid, nonassessable shares of
common stock of the Company, par value $0.0001 per share (the "Common Stock"),
on the terms, and subject to the conditions, set forth in the Indenture. As used
herein, "Conversion Shares" means the shares of Common Stock into which the
Notes are convertible. The Notes will be issued pursuant to



                                       1
<PAGE>


an Indenture (the "Indenture") to be dated as of the First Delivery Date (as
defined in Section 2(a)), between the Company and Chase Manhattan Bank and Trust
Company, National Association, as Trustee (the "Trustee").

         The Notes will be offered and sold without being registered under the
Securities Act of 1933, as amended (the "Securities Act"), in reliance on
exemptions therefrom. The Company has prepared and delivered to each Initial
Purchaser copies of a preliminary offering memorandum dated January 31, 2000
(the "Preliminary Offering Memorandum") and has prepared and will deliver to
each Initial Purchaser, on the date hereof or the next succeeding day, copies of
a final offering memorandum dated February 2, 2000 (the "Final Offering
Memorandum"), each for use by such Initial Purchaser in connection with its
solicitation of purchases of, or offering of, the Notes. "Offering Memorandum"
means, with respect to any date or time referred to in this Agreement, the most
recent offering memorandum (whether the Preliminary Offering Memorandum or the
Final Offering Memorandum, or any amendment or supplement to either such
document), including exhibits thereto and any documents incorporated therein by
reference, which has been prepared and delivered by the Company to the Initial
Purchasers in connection with their solicitation of purchases of, or offering
of, the Notes.

         Holders of the Notes (including the Initial Purchasers and their direct
and indirect transferees) will be entitled to the benefits of a Resale
Registration Rights Agreement, dated the First Delivery Date, between the
Company and the Initial Purchasers (the "Registration Rights Agreement"),
pursuant to which the Company will agree to file with the Securities and
Exchange Commission (the "Commission") a shelf registration statement pursuant
to Rule 415 under the Securities Act (the "Registration Statement") covering the
resale of the Notes and the Conversion Shares, and to use its best efforts to
cause the Registration Statement to be declared effective.

         This Agreement, the Indenture, the Notes and the Registration Rights
Agreement are referred to herein collectively as the "Operative Documents".

         Capitalized terms used herein without definition have the respective
meanings specified in the Offering Memorandum.

1. REPRESENTATIONS, WARRANTIES AND AGREEMENTS OF THE COMPANY. The Company
represents and warrants to each Initial Purchaser as of the date hereof and as
of each Delivery Date (as defined in Section 2(b)) and agrees with each Initial
Purchaser, as follows:

         (a) Each of the Preliminary Offering Memorandum and the Offering
Memorandum, did not as of its respective date, and the Offering Memorandum will
not as of a Delivery Date (as defined in Section 2(b)), contain any untrue
statement of a material fact or omit to state a material fact necessary in order
to make the statements therein, in the light of the circumstances under which
they were made, not misleading; PROVIDED that the Company makes no
representation or warranty as to information contained in or omitted from the
Preliminary Offering Memorandum or the Offering Memorandum in reliance upon and
in conformity with written information furnished to the Company by or on the
behalf of any Initial Purchaser through the Representatives specifically for
inclusion therein.



                                       2
<PAGE>


         (b) Assuming the accuracy of the representations and warranties of the
Initial Purchasers contained in Section 6 and their compliance with the
agreements set forth therein, it is not necessary, in connection with the
issuance and sale of the Notes to the Initial Purchasers and the offer, resale
and delivery of the Notes by the Initial Purchasers in the manner contemplated
by this Agreement, the Indenture, the Registration Rights Agreement and the
Offering Memorandum, to register the Notes or the Conversion Shares under the
Securities Act or to qualify the Indenture under the Trust Indenture Act of
1939, as amended (the "Trust Indenture Act").

         (c) The Company has been duly incorporated and is validly existing as a
corporation in good standing under the laws of the State of Delaware, is duly
qualified to do business and is in good standing as a foreign corporation in
each jurisdiction in which its ownership or lease of property or the conduct of
its businesses requires such qualification (except for where the failure to be
so qualified would not have a material adverse effect on the affairs,
management, business, properties, financial condition, results of operations or
prospects of the Company, whether or not arising in the ordinary course of
business (a "Material Adverse Effect")), and has all power and authority
necessary to own or hold its properties and to conduct the businesses in which
it is engaged, as described in the Offering Memorandum; and the Company has no
subsidiaries.

         (d) The authorized, issued and outstanding capital stock of the
Company, as of September 30, 1999, is as set forth in the Offering Memorandum
under the column entitled "Actual" under the caption "Capitalization", and all
of the issued and outstanding shares of capital stock of the Company have been
duly and validly authorized and issued, are fully paid and nonassessable; none
of the outstanding shares of capital stock of the Company was issued in
violation of the preemptive or other similar rights of any securityholder of the
Company; the capital stock of the Company conforms to the description thereof
contained in the Offering Memorandum and such description conforms to the rights
set forth in the instruments defining the same; the Conversion Shares, which are
authorized on the date hereof, have been duly and validly authorized and
reserved for issuance upon conversion of the Notes by all necessary corporate
action and are free of preemptive rights; all Conversion Shares, when so issued
and delivered upon such conversion in accordance with the terms of the
Indenture, will be duly and validly authorized and issued, fully paid and
nonassessable and free and clear of all liens, encumbrances, equities or claims;
and the issuance of such Conversion Shares upon such conversion will not be
subject to the preemptive or other similar rights of any securityholder of the
Company.

         (e) The execution, delivery and performance of the Operative Documents
by the Company and the issuance of the Notes and the Conversion Shares and the
consummation of the transactions contemplated hereby and thereby will not (x)
conflict with or result in a breach or violation of any of the terms or
provisions of, or constitute a default under, any indenture, mortgage, deed of
trust, loan agreement or other agreement or instrument to which the Company is a
party or by which the Company is bound or to which any of the properties or
assets of the Company is subject, (y) result in any violation of the provisions
of the certificate of incorporation or bylaws of the Company or (z) result in
any violation of any statute or any order, rule or regulation of any court or
governmental agency or body having jurisdiction over the



                                       3
<PAGE>


Company or any of its properties or assets; and except (i) with respect to the
transactions contemplated by the Registration Rights Agreement, as may be
required under the Securities Act, the Trust Indenture Act and the rules and
regulations promulgated thereunder and (ii) as required by the state securities
or "blue sky" laws, no consent, approval, authorization or order of, or filing
or registration with, any such court or governmental agency or body is required
for the execution, delivery and performance of the Operative Documents by the
Company, and the consummation of the transactions contemplated hereby and
thereby.

         (f) The Company has all necessary corporate right, power and authority
to execute and deliver this Agreement and perform its obligations hereunder; and
this Agreement and the transactions contemplated hereby have been duly
authorized, executed and delivered by the Company.

         (g) The Company has all necessary corporate right, power and authority
to execute and deliver the Indenture and perform its obligations thereunder; the
Indenture has been duly authorized by the Company, and upon the effectiveness of
the Registration Statement, will be qualified under the Trust Indenture Act; on
the First Delivery Date, the Indenture will have been duly executed and
delivered by the Company and, assuming due authorization, execution and delivery
of the Indenture by the Trustee, will constitute a legally valid and binding
agreement of the Company enforceable against the Company in accordance with its
terms, except as the enforceability thereof may be limited by bankruptcy,
insolvency, fraudulent transfer, reorganization, moratorium and other similar
laws relating to or affecting creditors' rights generally, subject to general
principles of equity and to limitations on availability of equitable relief,
including specific performance (whether considered in a proceeding in equity or
at law) and an implied covenant of good faith and fair dealing; and the
Indenture conforms in all material respects to the description thereof contained
in the Offering Memorandum and will be in substantially the form last delivered
to the Initial Purchasers prior to the date of this Agreement.

         (h) The Company has all necessary corporate right, power and authority
to execute and deliver the Registration Rights Agreement and perform its
obligations thereunder; the Registration Rights Agreement and the transactions
contemplated thereby have been duly authorized by the Company; when the
Registration Rights Agreement is duly executed and delivered by the Company
(assuming due authorization, execution and delivery by the Initial Purchasers),
it will be a legally valid and binding agreement of the Company enforceable
against the Company in accordance with its terms, except as the enforceability
thereof may be limited by bankruptcy, insolvency, fraudulent transfer,
reorganization, moratorium and other similar laws relating to or affecting
creditors' rights generally, subject to general principles of equity and to
limitations on availability of equitable relief, including specific performance
(whether considered in a proceeding in equity or at law) and an implied covenant
of good faith and fair dealing, and except with respect to the rights of
indemnification and contribution thereunder, where enforcement thereof may be
limited by federal or state securities laws or the policies underlying such
laws; and the Registration Rights Agreement conforms in all material respects to
the description thereof contained in the Offering Memorandum and will be in
substantially the form last delivered to the Initial Purchasers prior to the
date of this Agreement.



                                       4
<PAGE>


         (i) The Company has all necessary corporate right, power and authority
to execute, issue and deliver the Notes and perform its obligations thereunder;
the Notes have been duly authorized by the Company; when the Notes are executed,
authenticated and issued in accordance with the terms of the Indenture and
delivered to and paid for by the Initial Purchasers pursuant to this Agreement
on the respective Delivery Date (assuming due authentication of the Notes by the
Trustee), such Notes will constitute legally valid and binding obligations of
the Company, entitled to the benefits of the Indenture and enforceable against
the Company in accordance with their terms, except as the enforceability thereof
may be limited by bankruptcy, insolvency, fraudulent transfer, reorganization,
moratorium and other similar laws relating to or affecting creditors' rights
generally, subject to general principles of equity and to limitations on
availability of equitable relief, including specific performance (whether
considered in a proceeding in equity or at law) and an implied covenant of good
faith and fair dealing; and the Notes conform in all material respects to the
description thereof contained in the Offering Memorandum and will be in
substantially the form last delivered to the Initial Purchasers prior to the
date of this Agreement.

         (j) Except for the Registration Rights Agreement and the Stock Purchase
Agreement, dated January 18, 1995, between the Company and Pfizer, Inc.
("Pfizer"), the Stock Purchase Agreement, dated March 1, 1996, as amended,
between the Company and Baxter Healthcare Corporation, the Restated Investor
Rights Agreement, dated April 29, 1993, as amended October 29, 1993, among the
Company and certain stockholders of the Company, the Resale Registration Rights
Agreement, dated October 13, 1999, between the Company and the initial
purchasers named therein, and the Registration Rights Agreement between the
Company and Alliance Pharmaceutical Corp., dated January 24, 2000, there are no
contracts, agreements or understandings between the Company and any person
granting such person the right (other than rights which have been waived or
satisfied) to require the Company to file a registration statement under the
Securities Act with respect to any securities of the Company owned or to be
owned by such person or to require the Company to include such securities in any
securities being registered pursuant to any registration statement filed by the
Company under the Securities Act.

         (k) The Company has not sustained, since the date of the latest audited
financial statements included in the Offering Memorandum, any material loss or
interference with its business from fire, explosion, flood or other calamity,
whether or not covered by insurance, or from any labor dispute or court or
governmental action, order or decree; and, since such dates, there has not been
any change in the capital stock or long-term debt of the Company or any material
adverse change in or affecting the affairs, management, business, properties,
financial condition, stockholders' equity, results of operations or prospects of
the Company, whether or not arising in the ordinary course of business, except:
(i) as described in the Offering Memorandum, (ii) any grants under the Company's
employee stock plans in accordance with the terms of such plans as described in
the Offering Memorandum, or other shares of Common Stock (or rights to receive
Common Stock) issued to service providers to the Company in the ordinary course
of business ("Authorized Grants"), (iii) operating losses incurred in the
ordinary course of business, (iv) shares of Common Stock issued in connection
with the Asset Purchase Agreement, dated October 4, 1999, between the Company
and Alliance Pharmaceutical Corp. (the "Alliance



                                       5
<PAGE>


Agreement"), (v) the issuance and sale of the Outstanding Debentures (as defined
below) or (vi) shares of Common Stock into which the Company's outstanding
6-3/4% Convertible Subordinated Debentures due 2006 are convertible (the
"Outstanding Debentures").

         (l) The financial statements of the Company (including the related
notes and supporting schedules) included in the Offering Memorandum present
fairly the financial condition and results of operations of the Company, at the
dates and for the periods indicated, and have been prepared in conformity with
generally accepted accounting principles applied on a consistent basis
throughout the periods involved. The selected financial information included in
the Offering Memorandum present fairly the information shown therein and have
been compiled on a basis consistent with that of the audited financial
statements included in the Offering Memorandum.

         (m) Ernst &Young LLP, who have certified the financial statements of
the Company included in the Offering Memorandum, whose report appears in the
Offering Memorandum, are independent accountants as required by the Securities
Act and the rules and regulations promulgated thereunder.

         (n) The Company has good and marketable title in fee simple to all real
property and good and marketable title to all personal property owned by it, in
each case free and clear of all liens, encumbrances, security interests, claims
and defects, except such as are described in the Offering Memorandum or such as
do not, singly or in the aggregate, materially affect the value of such property
and do not interfere with the use made and proposed to be made of such property
by the Company; and all real property and personal property held under lease or
sublease by the Company is held by it under valid, subsisting and enforceable
leases (or subleases, as the case may be) in full force and effect, with such
exceptions as are not material and do not interfere with the use made and
proposed to be made of such property by the Company. The Company has no notice
of any material claim of any sort that has been asserted by anyone adverse to
the rights of the Company under any of the leases or subleases mentioned above,
or affecting or questioning the rights of such the Company thereof to the
continued possession of the leased or subleased premises under any such lease or
sublease.

         (o) The Company carries, or is covered by, insurance as is customary
for companies similarly situated and engaged in similar businesses in similar
industries.

         (p) The Company owns, or possesses adequate rights to use, all material
trademarks, service marks, trade names, trademark registrations, service mark
registrations, copyrights and licenses necessary for the conduct of its
business, and has no reason to believe that the conduct of its business will
conflict with, and has not received any notice of any claim of conflict with,
any such rights of others.

         (q) The Company owns, or possesses adequate rights to use, all material
patents necessary for the conduct of its business. Except as set forth in the
Offering Memorandum, no valid U.S. patent is, or to the knowledge of the Company
would be, infringed by the activities of the Company in the manufacture, use,
offer for sale or sale of any product or component thereof as described in the
Offering Memorandum. The patent applications (the "Patent Applications")



                                       6
<PAGE>


filed by or on behalf of the Company described in the Offering Memorandum have
been properly prepared and filed on behalf of the Company; each of the Patent
Applications and patents (the "Patents") described in the Offering Memorandum is
assigned or licensed to the Company, and, except as set forth or contemplated in
the Offering Memorandum, no other entity or individual has any right or claim in
any Patent, Patent Application or any patent to be issued therefrom; and, to the
knowledge of the Company, each of the Patent Applications discloses potentially
patentable subject matter. There are no actions, suits or judicial proceedings
pending relating to patents or proprietary information to which the Company is a
party or of which any property of the Company is subject, and, to the knowledge
of the Company, no actions, suits or judicial proceedings are threatened by
governmental authorities or, except as set forth or contemplated in the Offering
Memorandum, others. The Company is not aware of, except as set forth or
contemplated in the Offering Memorandum, any claim by others that the Company is
infringing or otherwise violating any patents or other intellectual property
rights of others and is not aware of any rights of third parties to any of the
Company's Patent Applications, licensed Patents or licenses which could affect
materially the use thereof by the Company. Except as set forth in the Offering
Memorandum, the Company owns or possesses sufficient licenses or other rights to
use all patents, trade secrets, technology and know-how necessary to conduct the
Company's business as described in the Offering Memorandum.

         (r) Except as disclosed in the Offering Memorandum, the Company has
filed with the Food and Drug Administration (the "FDA") and the California Food
and Drug Branch ("CFDB") for and received approval of all registrations,
applications, licenses, requests for exemptions, permits and other regulatory
authorizations necessary to conduct the Company's business as it is described in
the Offering Memorandum; the Company is in material compliance with all such
registrations, applications, licenses, requests for exemptions, permits and
other regulatory authorizations, and all applicable FDA and CFDB rules and
regulations, guidelines and policies, including but not limited to, applicable
FDA and CFDB rules, regulations and policies relating to current good
manufacturing practice ("CGMP") and current good laboratory practice ("CGLP");
the Company has no reason to believe that any party granting any such
registration, application, license, request for exemption, permit or other
authorization is considering limiting, suspending or revoking the same and knows
of no basis for any such limitation, suspension or revocation.

         (s) The human clinical trials, animal studies and other preclinical
tests conducted by the Company or in which the Company has participated that are
described in the Offering Memorandum or the results of which are referred to in
the Offering Memorandum, and, to the knowledge of the Company, such studies and
tests conducted on behalf of the Company, were and, if still pending, are being
conducted in accordance with commonly used or appropriate experimental
protocols, procedures and controls applied by research scientists generally in
the preclinical or clinical study of new drugs; the descriptions or the results
of such studies and tests contained in the Offering Memorandum are accurate and
complete in all material respects, and the Company has no knowledge of any other
studies or tests, the results of which reasonably call into question the results
described or referred to in the Offering Memorandum; and the Company has not
received any notices or other correspondence from the FDA or any other
governmental agency requiring the termination, suspension or modification of any
animal studies or other preclinical tests, or clinical studies conducted by or
on behalf of the Company or in which the



                                       7
<PAGE>


Company has participated that are described in the Offering Memorandum or the
results of which are referred to in the Offering Memorandum.

         (t) Except as disclosed in the Offering Memorandum, there are no legal
or governmental proceedings pending to which the Company is a party or of which
any property or asset of the Company is the subject which, if determined
adversely to the Company might have a Material Adverse Effect, or which might
reasonably be expected to materially and adversely affect the consummation of
the transactions contemplated by this Agreement or the performance by the
Company of its obligations hereunder; to the Company's knowledge, no such
proceedings are threatened or contemplated by governmental authorities or,
except as set forth or contemplated in the Offering Memorandum, threatened by
others; and the aggregate of all pending legal or governmental proceedings to
which the Company is a party or of which any of its property or assets is the
subject (other than the Company's patent applications currently pending before
the U.S. Patent and Trademark Office or before any foreign governmental
authority that administers the registration of patents), which are not described
in the Offering Memorandum, including ordinary routine litigation incidental to
the business, could not reasonably be expected to result in a Material Adverse
Effect.

         (u) No event has occurred nor has any circumstance arisen which, had
the Notes been issued on such Delivery Date, would constitute a default or an
Event of Default (as such term is defined in the Indenture).

         (v) The Company is not (i) in violation of its certificate of
incorporation or bylaws, (ii) in default, and no event has occurred which, with
notice or lapse of time or both, would constitute such a default, in the due
performance or observance of any term, covenant or condition contained in any
indenture, mortgage, deed of trust, loan agreement or other agreement or
instrument to which it is a party or by which it is bound or to which any of its
properties or assets is subject or (iii) in violation of any law, ordinance,
governmental rule, regulation or court decree to which it or its properties or
assets may be subject or has failed to obtain any license, permit, certificate,
franchise or other governmental authorization or permit necessary to the
ownership of its properties or to the conduct of its business, except to the
extent that any such default, event or violation described in the foregoing
clauses (i), (ii) and (iii) would not have a Material Adverse Effect.

         (w) The Company is in compliance in all material respects with all
presently applicable provisions of the Employee Retirement Income Security Act
of 1974, as amended, including the regulations and published interpretations
thereunder ("ERISA"); no "reportable event" (as defined in ERISA) has occurred
with respect to any "pension plan" (as defined in ERISA) for which the Company
would have any liability; the Company has not incurred and does not expect to
incur liability under (i) Title IV of ERISA with respect to termination of, or
withdrawal from, any "pension plan" or (ii) Sections 412 or 4971 of the Internal
Revenue Code of 1986, as amended, including the regulations and published
interpretations thereunder (the "Code"); and each "pension plan" for which the
Company would have any liability that is intended to be qualified under Section
401(a) of the Code is so qualified in all material respects and nothing has
occurred, whether by action or by failure to act, which would cause the loss of
such qualification.



                                       8
<PAGE>


         (x) The Company is subject to the reporting requirements of Section 13
or Section 15(d) of the Exchange Act. The Company has timely and properly filed
with the Commission all reports and other documents required to have been filed
by it with the Commission pursuant to the Exchange Act and the Exchange Act
Regulations ("Exchange Act Reports"); PROVIDED, HOWEVER, that the Company makes
no such representation or warranty with respect to any statement in or omission
from the Exchange Act Reports relating, directly or indirectly, to the
conversion of any Outstanding Debentures.

         (y) The Company has filed all federal, state and local income and
franchise tax returns required to be filed through the date hereof or has
requested extensions thereof and has paid all taxes due thereon, and no tax
deficiency has been determined adversely to the Company which has had (nor does
the Company have any knowledge of any tax deficiency which, if determined
adversely to the Company, might have) a Material Adverse Effect.

         (z) There has been no storage, disposal, generation, manufacture,
refinement, transportation, handling or treatment of toxic wastes, medical
wastes, hazardous wastes or hazardous substances by the Company (or, to the
knowledge of the Company, any of its predecessors in interest) at, upon or from
any of the property now or previously owned or leased by the Company in
violation of any applicable law, ordinance, rule, regulation, order, judgment,
decree or permit or which would require remedial action under any applicable
law, ordinance, rule, regulation, order, judgment, decree or permit, except for
any violation or remedial action which would not have, or could not be
reasonably likely to have, singularly or in the aggregate with all such
violations and remedial actions a Material Adverse Effect; there has been no
material spill, discharge, leak, emission, injection, escape, dumping or release
of any kind onto such property or into the environment surrounding such property
of any toxic wastes, medical wastes, solid wastes, hazardous wastes or hazardous
substances due to or caused by the Company or with respect to which the Company
has knowledge, except for any such spill, discharge, leak, emission, injection,
escape, dumping or release which would not have or would not be reasonably
likely to have, singularly or in the aggregate with all such spills, discharges,
leaks, emissions, injections, escapes, dumpings and releases, a Material Adverse
Effect; and the terms "hazardous wastes", "toxic wastes", "hazardous substances"
and "medical wastes" shall have the meanings specified in any applicable local,
state, federal and foreign laws or regulations with respect to environmental
protection.

         (aa) There are no contracts or other documents which would be required
to be described in the Offering Memorandum if the Offering Memorandum were a
prospectus included in a registration statement on Form S-1 that have not been
so described in the Offering Memorandum.

         (bb) There is no relationship, direct or indirect, between or among the
Company, on the one hand, and the directors, officers, shareholders, customers
or suppliers of the Company, on the other hand, which would be required to be
described in the Offering Memorandum if the Offering Memorandum were a
prospectus included in a registration statement on Form S-1 that has not been so
described.



                                       9
<PAGE>


         (cc) Since the date as of which information is given in the Offering
Memorandum through the date hereof, the Company has not (i) issued or granted
any securities (other than Authorized Grants or the Old Conversion Shares), (ii)
incurred any material liability or obligation, direct or contingent, other than
liabilities and obligations which were incurred in the ordinary course of
business, (iii) entered into any material transaction not in the ordinary course
of business (other than privately negotiated transactions relating to the
conversion of any Outstanding Debentures as described in the Offering
Memorandum) or (iv) declared or paid any dividend on its capital stock.

         (dd) Except as disclosed in the Offering Memorandum, (i) there are no
outstanding securities convertible into or exchangeable for, or warrants, rights
or options issued by the Company to purchase, any shares of the capital stock of
the Company (except, in the case of options, any Authorized Grants), (ii) there
are no statutory, contractual, preemptive or other rights to subscribe for or to
purchase any Common Stock that do not by their terms terminate upon the First
Delivery Date and (iii) there are no restrictions upon transfer of the Common
Stock pursuant to the Company's certificate of incorporation or bylaws.

         (ee) The Company (i) makes and keeps materially accurate books and
records and (ii) maintains internal accounting controls which provide reasonable
assurance that (A) transactions are executed in accordance with management's
authorization, (B) transactions are recorded as necessary to permit preparation
of its financial statements and to maintain accountability for its assets, (C)
access to its assets is permitted only in accordance with management's
authorization and (D) the reported accountability for its assets is compared
with existing assets at reasonable intervals.

         (ff) Neither the Company nor any director, officer, agent or employee
acting on behalf of the Company has (i) used any corporate funds for any
unlawful contribution, gift, entertainment or other unlawful expense relating to
political activity, (ii) made any direct or indirect unlawful payment to any
foreign or domestic government official or employee from corporate funds, (iii)
violated or is in violation of any provision of the Foreign Corrupt Practices
Act of 1977 or (iv) made any bribe, rebate, payoff, influence payment, kickback
or other unlawful payment.

         (gg) No labor disturbance by the employees of the Company exists or, to
the knowledge of the Company, is imminent which might be expected to have a
Material Adverse Effect.

         (hh) The Company is not, and upon the issuance and sale of the Notes as
herein contemplated and the application of the net proceeds therefrom as
described in the Offering Memorandum will not be, an "investment company" or an
entity "controlled" by an "investment company" as such terms are defined in the
Investment Company Act of 1940, as amended.

         (ii) Assuming the accuracy of the representations and warranties of the
Initial Purchasers contained in Section 6 and their compliance with the
agreements set forth therein, the Securities will be eligible for resale
pursuant to Rule 144A. No securities of the same class (within the meaning of
Rule 144A(d)(3) under the Securities Act) as the Notes are listed on any
national



                                       10
<PAGE>


securities exchange registered under Section 6 of the Exchange Act or quoted on
an automated inter-dealer quotation system.

         (jj) None of the Company or any of its Affiliates (as defined in Rule
501(b) of Regulation D under the Securities Act ("Regulation D")) (other than
the Initial Purchasers, about which no representation is made by the Company),
has, directly or through an agent, engaged or will engage in any form of general
solicitation or general advertising in connection with the offering of the Notes
(as those terms are used in Regulation D) under the Securities Act or in any
manner involving a public offering within the meaning of Section 4(2) of the
Securities Act; the Company has not entered into any contractual arrangement
with respect to the distribution of the Notes except for this Agreement and the
Company will not enter into any such arrangement.

         (kk) None of the Company or any of its affiliates (other than the
Initial Purchasers, about which no representation is made by the Company), has,
directly or through any agent, sold, offered for sale, solicited offers to buy
or otherwise negotiated in respect of, any "security" (as defined in the
Securities Act) which is or will be integrated with the sale of the Notes in a
manner that would require the registration under the Securities Act of the
Notes.

         (ll) The Company has not taken, directly or indirectly, any action
designed to cause or result in, or which has constituted or which might
reasonably be expected to constitute, the stabilization or manipulation of the
price of any security of the Company in connection with the offering of the
Notes.

2. PURCHASE, SALE AND DELIVERY OF NOTES.

         (a) Subject to the terms and conditions and in reliance upon the
representations and warranties herein set forth, the Company agrees to sell to
each Initial Purchaser, and each Initial Purchaser agrees, severally and not
jointly, to purchase from the Company, at a purchase price of 96.875% of the
principal amount thereof (the "purchase price") the principal amount of Firm
Notes set forth opposite such Initial Purchaser's name in SCHEDULE I hereto (or
such number increased as set forth in Section 8).

         Delivery of and payment for the Firm Notes shall be made at the office
of Brown & Wood LLP, One World Trade Center, New York, New York 10048, at 10:00
a.m. (New York City time) on February 8, 2000, or such later date as the Initial
Purchasers shall designate, which date and time may be postponed by agreement
between the Initial Purchasers and the Company or as provided in Section 8 (such
date and time of delivery and payment for the Firm Notes being herein called the
"First Delivery Date"). Delivery of the Firm Notes shall be made to the Initial
Purchasers against payment of the purchase price by the Initial Purchasers.
Payment for the Firm Notes shall be effected either by wire transfer of
immediately available funds to an account with a bank in The City of New York,
the account number and the ABA number for such bank to be provided by the
Company to the Initial Purchasers at least two business days in advance of the
First Delivery Date, or by such other manner of payment as may be agreed by the
Company and the Initial Purchasers. It is understood that each Initial Purchaser
has authorized the Representatives, for its account, to accept delivery of,
issue a receipt for, and make payment of the purchase price for, the Firm Notes
that it has agreed to purchase. Merrill Lynch, individually



                                       11
<PAGE>


and not as representative of the Initial Purchasers, may (but shall not be
obligated to) make payment of the purchase price for the Firm Notes to be
purchased by any Initial Purchaser whose funds have not been received by the
First Delivery Date but such payment shall not relieve such Initial Purchaser
from its obligations hereunder.

         (b) Subject to the terms and conditions and in reliance upon the
representations and warranties herein set forth, the Company hereby grants the
Option to the Initial Purchasers to purchase, severally and not jointly, the
Optional Notes at the same price as the Initial Purchasers shall pay for the
Firm Notes and the principal amount of the Optional Notes to be sold to each
Initial Purchaser shall be that principal amount which bears the same ratio to
the aggregate principal amount of Optional Notes being purchased as the
principal amount of Firm Notes set forth opposite the name of such Initial
Purchaser in SCHEDULE I hereto (or such number increased as set forth in Section
8). The Option may be exercised only to cover over-allotments in the sale of the
Firm Notes by the Initial Purchasers. The Option may be exercised once in whole
or in part at any time not more than 30 days subsequent to the date of this
Agreement upon notice in writing or by facsimile by the Representatives to the
Company setting forth the amount (which shall be an integral multiple of $1,000)
of Optional Notes as to which the Initial Purchasers are exercising the Option.

         The date for the delivery of and payment for the Optional Notes, being
herein referred to as an "Optional Delivery Date", which may be the First
Delivery Date (the First Delivery Date and the Optional Delivery Date, if any,
being sometimes referred to as a "Delivery Date"), shall be determined by the
Initial Purchasers but shall not be later than five full business days after
written notice of election to purchase Optional Notes is given. Delivery of the
Optional Notes shall be made to the Initial Purchasers against payment of the
purchase price by the Initial Purchasers. Payment for the Optional Notes shall
be effected either by wire transfer of immediately available funds to an account
with a bank in The City of New York, the account number and the ABA number for
such bank to be provided by the Company to the Initial Purchasers at least two
business days in advance of the Optional Delivery Date, or by such other manner
of payment as may be agreed by the Company and the Initial Purchasers. It is
understood that each Initial Purchaser has authorized the Representatives, for
its account, to accept delivery of, issue a receipt for, and make payment of the
purchase price for, the Optional Notes that it has agreed to purchase. Merrill
Lynch, individually and not as representative of the Initial Purchasers, may
(but shall not be obligated to) make payment of the purchase price for the
Optional Notes to be purchased by any Initial Purchaser whose funds have not
been received by the Delivery Date but such payment shall not relieve such
Initial Purchaser from its obligations hereunder.

         (c) The Company will deliver against payment of the purchase price the
Notes initially sold to qualified institutional buyers ("QIBs"), as defined in
Rule 144A under the Securities Act ("Rule 144A") in the form of one or more
permanent global certificates (the "Global Notes"), registered in the name of
Cede & Co., as nominee for The Depository Trust Company ("DTC"). Beneficial
interests in the Notes initially sold to QIBs will be shown on, and transfers
thereof will be effected only through, records maintained in book-entry form by
DTC and its participants.



                                       12
<PAGE>


         The Global Notes will be made available, at the request of the Initial
Purchasers, for checking at least 24 hours prior to such Delivery Date. The
Certificated Notes will be made available, at the request of the Initial
Purchasers, for checking at least 48 hours prior to such Delivery Date.

         (d) Time shall be of the essence, and delivery at the time and place
specified pursuant to this Agreement is a further condition of the obligations
of the Initial Purchasers hereunder.

3. FURTHER AGREEMENTS OF THE COMPANY. The Company further agrees with each
Initial Purchaser as follows:

         (a) The Company will advise the Initial Purchasers promptly of any
proposal to amend or supplement the Offering Memorandum and not to effect any
such amendment or supplement without the consent of the Initial Purchasers
and/or Brown & Wood LLP, counsel to the Initial Purchasers. Neither the consent
of the Initial Purchasers, nor the Initial Purchaser's delivery of any such
amendment or supplement, shall constitute a waiver of any of the conditions set
forth in Section 5. The Company will immediately notify each Initial Purchaser,
and confirm such notice in writing, of (i) any filing made by the Company of
information relating to the offering of the Notes by the Company with any
securities exchange or any other regulatory body in the United States or any
other jurisdiction, and (ii) prior to the completion of the placement of the
Notes by the Initial Purchasers as evidenced by a notice in writing from the
Initial Purchasers to the Company, any material changes in or affecting the
condition, financial or otherwise, or the earnings, business affairs or business
prospects of the Company which (x) make any statement in the Offering Memorandum
false or misleading or (y) are not disclosed in the Offering Memorandum. In such
event or if during such time any event shall occur or condition exist as a
result of which it is necessary to amend or supplement the Offering Memorandum
in order that the Offering Memorandum will not include an untrue statement of a
material fact or omit to state a material fact necessary in order to make the
statements therein, in the light of the circumstances existing at the time it is
delivered to a purchaser, not misleading, to promptly notify the Initial
Purchasers and/or Brown & Wood LLP, counsel to the Initial Purchasers, and
prepare, subject to the first sentence of this Section 3(a), such amendment or
supplement as may be necessary to correct such untrue statement or omission.

         (b) The Company will furnish to the Initial Purchasers and to Brown &
Wood LLP, counsel to the Initial Purchasers, copies of the Preliminary Offering
Memorandum and the Offering Memorandum (and all amendments and supplements
thereto) in each case as soon as available and in such quantities as the Initial
Purchasers reasonably request for internal use and for distribution to
prospective purchasers; and to furnish to the Initial Purchasers on the date
hereof four copies of the Offering Memorandum signed by duly authorized officers
of the Company, one of which will include the independent auditors' reports
therein manually signed by such independent auditors. The Company will pay the
expenses of printing and distributing to the Initial Purchasers all such
documents.

         (c) The Company will use its reasonable efforts to take such action as
the Initial Purchasers may reasonably request from time to time, to qualify the
Notes and the Conversion



                                       13
<PAGE>


Shares for offering and sale under the securities laws of such jurisdictions as
the Initial Purchasers may request and to comply with such laws so as to permit
the continuance of sales and dealings therein in such jurisdictions in the
United States for as long as may be necessary to complete the resale of the
Notes; PROVIDED that in connection therewith, the Company shall not be required
to qualify as a foreign corporation or otherwise subject itself to taxation in
any jurisdiction in which it is not otherwise so qualified or subject.

         (d) The Company will apply the proceeds from the sale of the Notes as
set forth under "Use of Proceeds" in the Offering Memorandum.

         (e) During a period of 90 days from the date of the Offering
Memorandum, the Company will not, and will cause its directors and officers not
to, without the prior written consent of Merrill Lynch, (i) directly or
indirectly, offer, pledge, sell, contract to sell, sell any option or contract
to purchase, purchase any option or contract to sell, grant any option right or
warrant to purchase or otherwise transfer or dispose of any Common Stock or any
securities convertible into or exercisable or exchangeable for Common Stock
(collectively, the "Restricted Securities") or file any registration statement
under the Securities Act with respect to any Restricted Securities, or (ii)
enter into any swap or any other agreement or any transaction (other than the
Operative Documents) that transfers, in whole or in part, directly or
indirectly, the economic consequence of ownership of any Restricted Securities,
whether any such swap or transaction described in clause (i) or (ii) above is to
be settled by delivery of Restricted Securities, in cash or otherwise. The
foregoing sentence shall not apply to Authorized Grants, the Old Conversion
Shares, the Conversion Shares or the sale of up to $125 million in the aggregate
of the Company's Common Stock (as measured on the date of such sales(s)) only
(x) in a private placement or (y) in connection with the Company's acquisition
of a company not subject to the reporting requirements of the Exchange Act. The
Company further agrees not to permit to become effective under the Securities
Act during a period of 90 days from the date of the Offering Memorandum a
registration statement covering any shares of the Company's Common Stock sold
pursuant to a transaction described in clauses (x) and (y) above. The Company
further agrees to cause each officer and director of the Company to furnish to
the Initial Purchasers, prior to the First Delivery Date, a letter or letters,
in form and substance satisfactory to counsel to the Initial Purchasers,
pursuant to which each such person shall agree not to enter into any transaction
described in clause (i) or (ii) of the first sentence of this paragraph;
PROVIDED, HOWEVER, that such restrictions shall not apply to the sale of up to
400,000 shares of Common Stock in the aggregate by all such officers and
directors.

         (f) The Company agrees that it will not, and will cause its Affiliates
(as defined in Rule 501(b) of Regulation D) not to, directly or indirectly,
solicit any offer to buy, sell or make any offer or sale of, or otherwise
negotiate in respect of, securities of the Company of any class if, as a result
of the doctrine of "integration" referred to in Rule 502 under the Securities
Act, such offer or sale would render invalid (for the purpose of (i) the sale of
the Notes by the Company to the Initial Purchasers, (ii) the resale of the Notes
by the Initial Purchasers to subsequent purchasers or (iii) the resale of the
Notes or Conversion Shares by such subsequent purchasers to others) the
exemption from the registration requirements of the Securities Act provided by
Section 4(2) thereof or by Rule 144A thereunder or otherwise. Notwithstanding
the



                                       14
<PAGE>


foregoing, no stockholder of the Company that does not control, is not
controlled by or is not under common control with, an officer or director of the
Company shall be deemed to be an Affiliate for purposes of this paragraph.

         (g) For so long as any of the Notes are "restricted securities" within
the meaning of Rule 144(a)(3) under the Securities Act, the Company will provide
to any holder of the Notes or to any prospective purchaser of the Notes
designated by any holder, upon request of such holder or prospective purchaser,
information required to be provided by Rule 144A(d)(4) of the Securities Act if,
at the time of such request, the Company is not subject to the reporting
requirements under Section 13 or 15(d) of the Exchange Act.

         (h) Until the expiration of two years after the original issuance of
the Notes, the Company will not, and will cause its Affiliates (as defined in
Rule 501(b) of Regulation D) not to, resell any Notes or Conversion Shares which
are "restricted securities" (as such term is defined under Rule 144(a)(3) under
the Securities Act), whether as beneficial owner or otherwise (except as agent
acting as a securities broker on behalf of and for the account of customers in
the ordinary course of business in unsolicited broker's transactions).
Notwithstanding the foregoing, no stockholder of the Company that does not
control, is not controlled by or is not under common control with, an officer or
director of the Company shall be deemed to be an Affiliate for purposes of this
paragraph.

         (i) Each of the Notes will bear, to the extent applicable, the legend
contained in "Notice to Investors" in the Offering Memorandum for the time
period and upon the other terms stated therein, except after the Notes are
resold pursuant to a registration statement effective under the Securities Act.

         (j) The Company will take such steps as shall be necessary to ensure
that it shall not become an "investment company" within the meaning of such term
under the Investment Company Act, and the rules and regulations of the
Commission thereunder.

         (k) None of the Company or any of its affiliates will take, directly or
indirectly, any action which is designed to stabilize or manipulate, or which
constitutes or which might reasonably be expected to cause or result in
stabilization or manipulation, of the price of any security of the Company in
connection with the offering of the Notes.

         (l) The Company will execute and deliver the Registration Rights
Agreement in form and substance satisfactory to the Initial Purchasers.

         (m) The Company will use its best efforts to assist the Initial
Purchasers in arranging to cause the Notes to be accepted to trade in the PORTAL
market ("PORTAL") of the National Association of Securities Dealers, Inc.
("NASD").

         (n) The Company will use its best efforts to cause the Notes to be
accepted for clearance and settlement through the facilities of DTC.



                                       15
<PAGE>


         (o) The Company will use its best efforts to have the Conversion Shares
approved by the Nasdaq National Market ("Nasdaq") for inclusion prior to the
effectiveness of the Registration Statement.

         (p) The Company has not taken, and prior to March 1, 2000 shall not
take, directly or indirectly, any action which releases Baxter from or waives
any restriction imposed on Baxter with respect to the transfer of shares of
Common Stock contained in the Stock Purchase Agreement between Baxter and the
Company, dated March 1, 1996, as amended.

4. EXPENSES. The Company agrees to pay:

         (a) the costs incident to the authorization, issuance, sale and
delivery of the Notes, and any taxes payable in that connection;

         (b) the costs incident to the preparation, printing and distribution of
the Preliminary Offering Memorandum, the Offering Memorandum and any amendment
or supplement to the Offering Memorandum, all as provided in this Agreement;

         (c)  the costs of producing and distributing the Operative Documents;

         (d) the fees and expenses of Cooley Godward LLP and Ernst & Young LLP;

         (e) the costs of distributing the terms of agreement relating to the
organization of the underwriting syndicate and selling group to the members
thereof by mail, telex or other means of communication;

         (f) the fees and expenses of qualifying the Notes under the securities
laws of the several jurisdictions as provided in Section 3(c);

         (g) all costs and expenses incident to (i) the preparation of the "road
show" presentation materials and (ii) the road show travelling expenses of the
Company;

         (h)  the costs of preparing the Notes;

         (i) all expenses and fees in connection with the application for
inclusion of the Notes in the PORTAL market and the inclusion of the Conversion
Shares on the NASDAQ;

         (j) the fees and expenses (including fees and disbursements of counsel)
of the Trustee, and the costs and charges of any registrar, transfer agent,
paying agent or conversion agent; and

         (k) all other costs and expenses incident to the performance of the
obligations of the Company under this Agreement;

PROVIDED that, except as provided in this Section 4 and in Section 7, the
Initial Purchasers shall pay their own costs and expenses, including the costs
and expenses of their counsel and any transfer taxes on the Notes which they may
sell.



                                       16
<PAGE>


5. CONDITIONS OF THE INITIAL PURCHASERS' OBLIGATIONS. The several obligations of
the Initial Purchasers hereunder are subject to the accuracy, when made and on
each Delivery Date, of the representations and warranties of the Company
contained herein, to the performance by the Company of its obligations
hereunder, and to each of the following additional terms and conditions:

         (a) No Initial Purchaser shall have discovered and disclosed to the
Company prior to or on such Delivery Date that the Offering Memorandum or any
amendment or supplement thereto contains any untrue statement of a fact which,
in the opinion of counsel to the Initial Purchasers, is material or omits to
state any fact which is material and necessary to make the statements therein,
in the light of the circumstances under which they were made, not misleading.

         (b) All corporate proceedings and other legal matters incident to the
authorization, form and validity of the Operative Documents and the Offering
Memorandum or any amendment or supplement thereto, and all other legal matters
relating to the Operative Documents and the transactions contemplated thereby
shall be satisfactory in all material respects to counsel to the Initial
Purchasers, and the Company shall have furnished to such counsel all documents
and information that they may reasonably request to enable them to pass upon
such matters.

         (c) Cooley Godward LLP shall have furnished to the Initial Purchasers
their written opinion, as counsel to the Company, addressed to the Initial
Purchasers and dated such Delivery Date, in form and substance satisfactory to
the Initial Purchasers, to the effect that:

                  (i) The Company has been duly organized and is validly
existing as a corporation in good standing under the laws of the State of
Delaware, and, based solely on certificates of public officials, is duly
qualified to do business and is in good standing as a foreign corporation in
each jurisdiction in which its ownership or lease of property or the conduct of
its business requires such qualification, except where the failure to be so
qualified would not have a material adverse effect on the Company, whether or
not arising in the ordinary course of business, and has all corporate power and
authority necessary to own or hold its properties and conduct the businesses in
which it is engaged, as described in the Offering Memorandum; and, to the
knowledge of such counsel, the Company has no subsidiaries;

                  (ii) the Conversion Shares, which are authorized on the date
        hereof, have been duly and validly authorized and reserved for issuance
        upon conversion of the Notes by all necessary corporate action and are
        free of preemptive rights; all Conversion Shares, when so issued and
        delivered upon such conversion in accordance with the terms of the
        Indenture, will be duly and validly authorized and issued, fully paid
        and nonassessable and free and clear of all liens, encumbrances,
        equities or claims imposed by or arising from actions of the Company;

                  (iii) The statements in the Offering Memorandum under the
captions "Description of the Notes" and "Description of Capital Stock", insofar
as they purport to summarize the provisions of the Indenture, the Registration
Rights Agreement, the Notes and the Common Stock (including the Conversion
Shares) are accurate and complete in all material



                                       17
<PAGE>


respects to the extent required if such statements were contained in a
registration statement on Form S-3 under the Securities Act;

                  (iv) There is no restriction upon the voting or transfer of,
any shares of Common Stock pursuant to the Company's certificate of
incorporation or bylaws;

                  (v) To the knowledge of such counsel and other than as set
forth in the Offering Memorandum, there are no legal or governmental proceedings
pending to which the Company is a party or of which any property or asset of the
Company is the subject which, if determined adversely to the Company might have
a material adverse effect on the Company or which might reasonably be expected
to materially and adversely affect the consummation of the transactions
contemplated by this Agreement or the performance by the Company of its
obligations hereunder; to the actual knowledge of such counsel, no such
proceedings are overtly threatened or contemplated by governmental authorities
or, except as set forth or contemplated in the Offering Memorandum, overtly
threatened by others; and, to the actual knowledge of such counsel, the
aggregate of all pending legal or governmental proceedings to which the Company
is a party or of which any of its property or assets is the subject (other than
the Company's patent applications currently pending before the U.S. Patent and
Trademark Office or before any foreign governmental authority that administers
the registration of patents) which are not described in the Offering Memorandum,
including ordinary routine litigation incidental to the business, could not
reasonably be expected to result in a material adverse effect on the Company.

                  (vi) The execution, delivery and performance of this
Agreement, the Indenture and the Registration Rights Agreement and the issuance
of the Notes and the Conversion Shares and the consummation of the transactions
contemplated hereby and thereby do not result in any violation of the provisions
of the certificate of incorporation or bylaws of the Company or any statute or
any order, rule or regulation known to such counsel of any court or governmental
agency or body having jurisdiction over the Company or any of its properties or
assets; and, except as may be required by the securities or "blue sky" laws of
any state of the United States in connection with the sale of the Notes, no
consent, approval, authorization or order of, or filing or registration with,
any such court or governmental agency or body is required for the execution,
delivery and performance of this Agreement and the Indenture by the Company and
the issuance of the Notes and the Conversion Shares and the consummation of the
transactions contemplated hereby and thereby;

                  (vii) No registration of the Notes or the Conversion Shares
under the Securities Act, and no qualification of the Indenture or an indenture
under the Trust Indenture Act, is required in connection with the offer, sale
and delivery of the Notes or in connection with the conversion of the Notes into
Conversion Shares, in each case, in the manner contemplated by the Offering
Memorandum, this Agreement and the Indenture;

                  (viii) The statements in the Offering Memorandum under the
caption "Certain United States Federal Income Tax Considerations", insofar as
they purport to constitute summaries of matters of United States federal income
tax law and regulations or legal conclusions with respect thereto, constitute
accurate summaries of the matters described therein



                                       18
<PAGE>


in all material respects to the extent required if such statements were
contained in a registration statement on Form S-3 under the Securities Act;

                  (ix) The Company is not an "investment company" within the
meaning of the Investment Company Act of 1940, as amended;

                  (x) The Company has all necessary corporate right, power and
authority to execute and deliver each of the Operative Documents to which it is
a party and to perform its obligations thereunder and to issue, sell and deliver
the Notes and the Conversion Shares to the Initial Purchasers;

                  (xi) This Agreement has been duly authorized, executed and
delivered by the Company;

                  (xii) The Indenture has been duly authorized, executed and
delivered by the Company and, assuming due authorization, execution and delivery
thereof by the Trustee, constitutes a legally valid and binding agreement of the
Company enforceable against the Company in accordance with its terms except as
the enforceability thereof may be limited by bankruptcy, insolvency, fraudulent
transfer, reorganization, moratorium and other similar laws relating to or
affecting creditors' rights generally, subject to general principles of equity
and to limitations on availability of equitable relief, including specific
performance (regardless of whether such enforceability is considered in a
proceeding in equity or at law) or by an implied covenant of good faith and fair
dealing;

                  (xiii) The Registration Rights Agreement has been duly
authorized, executed and delivered by the Company and, assuming due
authorization, execution and delivery thereof by the Initial Purchasers,
constitutes a valid and legally binding agreement of the Company enforceable
against the Company in accordance with its terms except as rights to indemnity
contained therein may be limited by applicable law and except as the
enforceability thereof may be limited by bankruptcy, insolvency, fraudulent
transfer, reorganization, moratorium and other similar laws relating to or
affecting creditors' rights generally, subject to general principles of equity
and to limitations on availability of equitable relief, including specific
performance (regardless of whether such enforceability is considered in a
proceeding in equity or at law), by an implied covenant of good faith and fair
dealing; and

                  (xiv) The Notes have been duly authorized by the Company and
when executed, issued and authenticated in accordance with terms of the
Indenture and delivered to and paid for by the Initial Purchasers, will
constitute legally valid and binding obligations of the Company, entitled to the
benefits of the Indenture and enforceable against the Company in accordance with
their terms except as the enforceability thereof may be limited by bankruptcy,
insolvency, fraudulent transfer, reorganization, moratorium and other similar
laws relating to or affecting creditors' rights generally, subject to general
principles of equity and to limitations on availability of equitable relief,
including specific performance (regardless of whether such enforceability is
considered in a proceeding in equity or at law) or by an implied covenant of
good faith and fair dealing.



                                       19
<PAGE>


         In rendering such opinion, such counsel may state that its opinion is
limited to matters governed by the federal laws of the United States of America,
the laws of the State of New York and the Delaware General Corporation Law and
may state that it is relying, in respect of matters of New York law, upon Brown
& Wood LLP, and in respect of matters of fact, upon certificates of officers of
the Company, PROVIDED that such counsel shall state that it believes that the
Initial Purchasers and it are justified in relying upon such certificates. Such
counsel shall also have furnished to the Initial Purchasers a written statement,
addressed to the Initial Purchasers and dated such Delivery Date, in form and
substance satisfactory to the Initial Purchasers, to the effect that during the
course of preparing the Offering Memorandum, such counsel participated in
conferences with officers and other representatives of the Company, the
Company's independent public accountants, the Initial Purchasers and their
counsel, at which the contents of the Offering Memorandum were discussed, and
while such counsel has not independently verified and is not passing upon the
accuracy, completeness or fairness of the statements made in the Offering
Memorandum except as explicitly set forth above, no facts have come to the
attention of such counsel which lead it to believe that the Offering Memorandum
(other than the financial statements, financial and statistical data and
supporting schedules as to which such counsel shall make no statement), as of
its date or as of such Delivery Date, contained or contains any untrue statement
of a material fact or omitted or omits to state a material fact necessary in
order to make the statements therein, in light of the circumstances under which
they were made, not misleading.

         (d) Stephen L. Hurst, Esq., General Counsel and Secretary of the
Company, shall have furnished to the Initial Purchasers his written opinion,
addressed to the Initial Purchasers and dated such Delivery Date, in form and
substance satisfactory to the Initial Purchasers, to the effect that:

                  (i) The authorized, issued and outstanding capital stock of
the Company, as of September 30, 1999, is as set forth in the Offering
Memorandum under the column entitled "Actual" under the caption
"Capitalization", and all of the issued and outstanding shares of capital stock
of the Company have been duly and validly authorized and issued, are fully paid
and nonassessable;

                  (ii) Except as disclosed in the Offering Memorandum, there are
no preemptive or other rights to subscribe for or to purchase from the Company,
or any restriction upon the voting or transfer of, any shares of Common Stock
pursuant to any agreement or other instrument to which the Company is a party
known to such counsel; the issuance of the Conversion Shares, upon conversion of
the Notes in accordance with the terms of the Indenture, will not be subject to
the preemptive or other similar rights of any securityholder of the Company and

                  (iii) The execution, delivery and performance of this
Agreement, the Indenture and the Registration Rights Agreement and the issuance
of the Notes and the Conversion Shares and the consummation of the transactions
contemplated hereby and thereby do not result in a breach or violation of any of
the terms or provisions of, or constitute a default under, any indenture,
mortgage, deed of trust, loan agreement or other agreement or instrument known
to



                                       20
<PAGE>


such counsel to which the Company is a party or by which the Company is bound or
to which any of the property or assets of the Company is subject.

         Such counsel shall also have furnished to the Initial Purchasers a
written statement, addressed to the Initial Purchasers and dated such Delivery
Date, in form and substance satisfactory to the Initial Purchasers, to the
effect that he has no reason to believe that the statements under the captions
"Risk Factors--Our patents may not protect our products and our products may
infringe on third-party patent rights" and "Patents and Proprietary Rights" in
the Offering Memorandum, as of its date or as of such Delivery Date, contained
or contains any untrue statement of a material fact or omitted or omits to state
a material fact necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading.

         (e) Brown & Wood LLP, shall have furnished to the Initial Purchasers
their written opinion, as counsel to the Initial Purchasers, addressed to the
Initial Purchasers and dated such Delivery Date, in form and substance
satisfactory to the Initial Purchasers.

         (f) With respect to the letter of Ernst & Young LLP delivered to the
Initial Purchasers concurrently with the execution of this Agreement (the
"initial letter"), the Company shall have furnished to the Initial Purchasers a
letter (the "bring-down letter") of such accountants, addressed to the Initial
Purchasers and dated such Delivery Date (i) confirming that they are independent
accountants within the meaning of the Securities Act and are in compliance with
the applicable requirements relating to the qualification of accountants under
Rule 2-01 of Regulation S-X of the Commission, (ii) stating, as of the date of
the bring-down letter (or, with respect to matters involving changes or
developments since the respective dates as of which specified financial
information is given in the Offering Memorandum, as of a date not more than five
days prior to the date of the bring-down letter), the conclusions and findings
of such firm with respect to the financial information and other matters covered
by the initial letter and (iii) confirming in all material respects the
conclusions and findings set forth in the initial letter.

         (g) The Company shall have furnished to the Initial Purchasers on such
Delivery Date a certificate, dated such Delivery Date and delivered on behalf of
the Company by one of its co-chief executive officers and its chief financial
officer, in form and substance satisfactory to the Initial Purchasers, to the
effect that:

                  (i) The representations, warranties and agreements of the
Company in Section 1 are true and correct as of the date given and as of such
Delivery Date; and the Company has complied in all material respects with all
its agreements contained herein to be performed prior to or on such Delivery
Date;

                  (ii) (A) The Company has not sustained since the date of the
latest audited financial statements included in the Offering Memorandum any loss
or interference with its business from fire, explosion, flood or other calamity,
whether or not covered by insurance, or from any labor dispute or court or
governmental action, order or decree, except (x) as set forth or contemplated in
the Offering Memorandum and (y) for operating losses incurred in the ordinary
course of business, or (B) since such date there has not been any change in the
capital stock or



                                       21
<PAGE>


long-term debt of the Company (except for issuances of shares of Common Stock
upon exercise of outstanding options described in the Offering Memorandum or
pursuant to Authorized Grants), or any change, or any development involving a
prospective change, in or affecting the general affairs, management, financial
position, stockholders' equity or results of operations of the Company, except
as set forth or contemplated in the Offering Memorandum; and

                  (iii) Such officer has carefully examined the Offering
Memorandum and, in such officer's opinion (A) the Offering Memorandum, as of its
date, did not include any untrue statement of a material fact and did not omit
to state any material fact necessary to make the statements therein, in the
light of the circumstances under which they were made, not misleading, and (B)
since the date of the Offering Memorandum, no event has occurred which should
have been set forth in a supplement or amendment to the Offering Memorandum.

         (h) The Indenture shall have been duly executed and delivered by the
Company and the Trustee and the Notes shall have been duly executed and
delivered by the Company and duly authenticated by the Trustee.

         (i) The Company and the Initial Purchasers shall have executed and
delivered the Registration Rights Agreement (in form and substance satisfactory
to the Initial Purchasers) and the Registration Rights Agreement shall be in
full force and effect.

         (j) The NASD shall have accepted the Notes for trading on PORTAL.

         (k) (i) The Company shall not have sustained since the date of the
latest audited financial statements included in the Offering Memorandum any loss
or interference with its business from fire, explosion, flood or other calamity,
whether or not covered by insurance, or from any labor dispute or court or
governmental action, order or decree, except (A) as set forth or contemplated in
the Offering Memorandum and (B) for operating losses incurred in the ordinary
course of business, or (ii) since such date there shall not have been any change
in the capital stock or long-term debt of the Company (except for issuances of
shares of Common Stock upon exercise of outstanding options described in the
Offering Memorandum or pursuant to Authorized Grants), or any change, or any
development involving a prospective change, in or affecting the general affairs,
management, financial position, stockholders' equity or results of operations of
the Company, except as set forth or contemplated in the Offering Memorandum, the
effect of which, in any such case described in clause (i) or (ii), is, in the
reasonable judgment of the Initial Purchasers, so material and adverse as to
make it impracticable or inadvisable to proceed with the sale or the delivery of
the Notes being delivered on such Delivery Date on the terms and in the manner
contemplated in the Offering Memorandum.

         (l) The Company shall have furnished to the Initial Purchasers such
further information, certificates and documents as the Initial Purchasers may
reasonably request to evidence compliance with the conditions set forth in this
Section 5.

         All opinions, letters, evidence and certificates mentioned above or
elsewhere in this Agreement shall be deemed to be in compliance with the
provisions hereof only if they are in form and substance satisfactory to counsel
to the Initial Purchasers.



                                       22
<PAGE>


         If any condition specified in this Section 5 shall not have been
fulfilled when and as required to be fulfilled, this Agreement may be terminated
by the Representatives by notice to the Company at any time at or prior to the
First Delivery Date, and such termination shall be without liability of any
party to any other party except as provided in Section 4 and except that
Sections 1 and 7 shall survive any such termination and remain in full force and
effect.

6. REPRESENTATIONS, WARRANTIES AND AGREEMENTS OF INITIAL PURCHASERS. Each
Initial Purchaser, severally and not jointly, represents and warrants that such
Initial Purchaser is a QIB. Each Initial Purchaser, severally and not jointly,
agrees with the Company that:

         (a) The Notes and the Conversion Shares have not been and will not be
registered under the Securities Act in connection with the initial offering of
the Notes.

         (b)  Such Initial Purchaser is a QIB;

         (c) Such Initial Purchaser will not offer or sell the Notes in the
United States by means of any form of general solicitation or general
advertising within the meaning of Rule 502(c) of Regulation D, including (i) any
advertisement, article, notice or other communication published in any
newspaper, magazine or similar medium or broadcast over television or radio, or
(ii) any seminar or meeting whose attendees have been invited by any general
solicitation or general advertising in the United States; and

         (d) Such Initial Purchaser has not offered or sold, and will not offer
or sell, any Notes in the United States except to persons whom it reasonably
believes to be QIBs.

7.   INDEMNIFICATION AND CONTRIBUTION.

         (a) The Company shall indemnify and hold harmless each Initial
Purchaser, its officers and employees and each person, if any, who controls any
Initial Purchaser within the meaning of Section 15 of the Securities Act or
Section 20 of the Exchange Act from and against any loss, claim, damage or
liability, joint or several, or any action in respect thereof (including, but
not limited to, any loss, claim, damage, liability or action relating to
purchases and sales of the Notes), to which that Initial Purchaser, officer,
employee or controlling person may become subject:

                  (i) insofar as such loss, claim, damage, liability or action
arises out of, or is based upon: (A) any untrue statement or alleged untrue
statement of a material fact contained in (I) any Preliminary Offering
Memorandum or the Offering Memorandum, or in any amendment or supplement
thereto, or (II) any blue sky application or other document prepared or executed
by the Company (or based upon any written information furnished by the Company)
filed in any jurisdiction specifically for the purpose of qualifying any or all
of the Notes under the securities laws of any state or other jurisdiction (such
application, document or information being hereinafter called a "Blue Sky
Application"), or (B) the omission or alleged omission to state therein any
material fact necessary to make the statements therein not misleading; or



                                       23
<PAGE>


                  (ii) to the extent of the aggregate amount paid in settlement
of any litigation, or any investigation or proceeding by any governmental agency
or body, commenced or threatened, or of any claim whatsoever based upon any such
untrue statement or omission, or any such alleged untrue statement or omission;
provided that (subject to Section 7(c)) any such settlement is effected with the
written consent of the Company,

and shall reimburse each Initial Purchaser and each such officer, employee and
controlling person promptly upon demand for any and all expense whatsoever, as
incurred (including the fees and disbursements of counsel chosen by Merrill
Lynch, except as reimbursement of such fees may be limited by Section 7(c)),
reasonably incurred by that Initial Purchaser, officer, employee or controlling
person in connection with investigating or defending or preparing to defend
against any such loss, claim, damage, liability or action as such expenses are
incurred; PROVIDED, HOWEVER, that the Company shall not be liable in any such
case to the extent that any such loss, claim, damage, liability or action arises
out of, or is based upon, any untrue statement or alleged untrue statement or
omission or alleged omission made in any Preliminary Offering Memorandum or the
Offering Memorandum, or in any such amendment or supplement, or in any Blue Sky
Application in reliance upon and in conformity with the written information
furnished to the Company by or on behalf of any Initial Purchaser specifically
for inclusion therein and described in Section 7(e); PROVIDED, FURTHER, that as
to any Preliminary Offering Memorandum, this indemnity agreement shall not inure
to the benefit of any Initial Purchaser, its officers or employees or any person
controlling that Initial Purchaser on account of any loss, claim, damage,
liability or action arising from the sale of Notes to any person by that Initial
Purchaser if that Initial Purchaser failed to send or give a copy of the
Offering Memorandum, as the same may be amended or supplemented, to that person,
and the untrue statement or alleged untrue statement of a material fact or
omission or alleged omission to state a material fact in such Preliminary
Offering Memorandum was corrected in the Offering Memorandum, unless such
failure resulted from non-compliance by the Company with Section 3(b). The
foregoing indemnity agreement is in addition to any liability which the Company
may otherwise have to any Initial Purchaser or to any officer, employee or
controlling person of that Initial Purchaser.

         (b) Each Initial Purchaser, severally and not jointly, shall indemnify
and hold harmless, the Company, its officers and directors, and each person, if
any, who controls the Company within the meaning of Section 15 of the Securities
Act or Section 20 of the Exchange Act from and against any loss, claim, damage
or liability, joint or several, or any action in respect thereof, to which the
Company or any such director, officer or controlling person may become subject,
insofar as such loss, claim, damage, liability or action arises out of, or is
based upon:

                  (i) any untrue statement or alleged untrue statement of a
material fact contained in any Preliminary Offering Memorandum or the Offering
Memorandum or in any amendment or supplement thereto, or in any Blue Sky
Application, or

                  (ii) the omission or alleged omission to state therein any
material fact necessary to make the statements therein not misleading,



                                       24
<PAGE>


but in each case only to the extent that such untrue statement or alleged untrue
statement or omission or alleged omission was made in reliance upon and in
conformity with the written information furnished to the Company by or on behalf
of that Initial Purchaser specifically for inclusion therein and described in
Section 7(e), and shall reimburse the Company and any such director, officer or
controlling person promptly upon demand for any legal or other expenses
reasonably incurred by the Company or any such director, officer or controlling
person in connection with investigating or defending or preparing to defend
against any such loss, claim, damage, liability or action as such expenses are
incurred. The foregoing indemnity agreement is in addition to any liability
which any Initial Purchaser may otherwise have to the Company or any such
director, officer or controlling person.

         (c) Promptly after receipt by an indemnified party under this Section 7
of notice of any claim or the commencement of any action, the indemnified party
shall, if a claim in respect thereof is to be made against the indemnifying
party under this Section 7, notify the indemnifying party in writing of the
claim or the commencement of that action; PROVIDED, HOWEVER, that the failure to
notify the indemnifying party shall not relieve it from any liability which it
may have under this Section 7 except to the extent it has been materially
prejudiced by such failure and, PROVIDED, FURTHER, that the failure to notify
the indemnifying party shall not relieve it from any liability which it may have
to an indemnified party otherwise than under this Section 7. If any such claim
or action shall be brought against an indemnified party, and it shall notify the
indemnifying party thereof, the indemnifying party shall be entitled to
participate therein and, to the extent that it wishes, jointly with any other
similarly notified indemnifying party, to assume the defense thereof with
counsel satisfactory to the indemnified party. After notice from the
indemnifying party to the indemnified party of its election to assume the
defense of such claim or action, the indemnifying party shall not be liable to
the indemnified party under this Section 7 for any legal or other expenses
subsequently incurred by the indemnified party in connection with the defense
thereof other than reasonable costs of investigation; PROVIDED, HOWEVER, that
the Initial Purchasers shall have the right to employ counsel to represent
jointly the Initial Purchasers and their respective officers, employees and
controlling persons who may be subject to liability arising out of any claim in
respect of which indemnity may be sought by the Initial Purchasers against the
Company under this Section 8, if the Initial Purchasers shall have reasonably
concluded that there may be one or more legal defenses available to the Initial
Purchasers and their respective officers, employees and controlling persons that
are different from or additional to those available to the Company and its
officers, employees and controlling persons, the fees and expenses of a single
separate counsel shall be paid by the Company. No indemnifying party shall:

                  (i) without the prior written consent of the indemnified
        parties (which consent shall not be unreasonably withheld) settle or
        compromise or consent to the entry of any judgment with respect to any
        pending or threatened claim, action, suit or proceeding in respect of
        which indemnification or contribution may be sought hereunder (whether
        or not the indemnified parties are actual or potential parties to such
        claim or action) unless such settlement, compromise or consent includes
        an unconditional release of each indemnified party from all liability
        arising out of such claim, action, suit or proceeding, or



                                       25
<PAGE>


                  (ii) be liable for any settlement of any such action effected
        without its written consent (which consent shall not be unreasonably
        withheld), but if settled with its written consent or if there be a
        final judgment of the plaintiff in any such action, the indemnifying
        party agrees to indemnify and hold harmless any indemnified party from
        and against any loss of liability by reason of such settlement or
        judgment.

         (d) If the indemnification provided for in this Section 7 shall for any
reason be unavailable or insufficient to hold harmless an indemnified party
under Section 7(a) or 7(b) in respect of any loss, claim, damage or liability,
or any action in respect thereof, referred to therein, each indemnifying party
shall, in lieu of indemnifying such indemnified party, contribute to the amount
paid or payable by such indemnified party as a result of such loss, claim,
damage or liability, or action in respect thereof:

                  (i) in such proportion as shall be appropriate to reflect the
relative benefits received by the Company on the one hand and the Initial
Purchasers on the other from the offering of the Notes, or

                  (ii) if the allocation provided by clause 7(d)(i) is not
permitted by applicable law, in such proportion as is appropriate to reflect not
only the relative benefits referred to in clause 7(d)(i) but also the relative
fault of the Company on the one hand and the Initial Purchasers on the other
with respect to the statements or omissions or alleged statements or alleged
omissions that resulted in such loss, claim, damage or liability (or action in
respect thereof), as well as any other relevant equitable considerations.

The relative benefits received by the Company on the one hand and the Initial
Purchasers on the other with respect to such offering shall be deemed to be in
the same proportion as the total net proceeds from the offering of the Notes
purchased under this Agreement (before deducting expenses) received by the
Company on the one hand, and the total discounts and commissions received by the
Initial Purchasers with respect to the Notes purchased under this Agreement, on
the other hand, bear to the total gross proceeds from the offering of the Notes
under this Agreement, in each case as set forth in the table on the cover page
of the Offering Memorandum. The relative fault shall be determined by reference
to whether the untrue or alleged untrue statement of a material fact or omission
or alleged omission to state a material fact relates to information supplied by
the Company or the Initial Purchasers, the intent of the parties and their
relative knowledge, access to information and opportunity to correct or prevent
such statement or omission. The Company and the Initial Purchasers agree that it
would not be just and equitable if the amount of contributions pursuant to this
Section 7(d) were to be determined by PRO RATA allocation (even if the Initial
Purchasers were treated as one entity for such purpose) or by any other method
of allocation which does not take into account the equitable considerations
referred to herein. The amount paid or payable by an indemnified party as a
result of the loss, claim, damage or liability, or action in respect thereof,
referred to above in this Section 7(d) shall be deemed to include, for purposes
of this Section 7(d), any legal or other expenses reasonably incurred by such
indemnified party in connection with investigating or defending any such action
or claim. Notwithstanding the provisions of this Section 7(d), no Initial
Purchaser shall be required to contribute any amount in excess of the amount by
which the total price at which the



                                       26
<PAGE>


Notes resold by it in the initial placement of such Notes were offered to
investors exceeds the amount of any damages which such Initial Purchaser has
otherwise been required to pay by reason of such untrue or alleged untrue
statement or omission or alleged omission. No person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act)
shall be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation. For purposes of this Section 7(d), each person, if
any, who controls an Initial Purchaser within the meaning of Section 15 of the
Securities Act or Section 20 of the Exchange Act shall have the same rights to
contribution as such Initial Purchaser, and each person, if any, who controls
the Company within the meaning of Section 15 of the Securities Act or Section 20
of the Exchange Act shall have the same rights to contribution as the Company.
The Initial Purchasers' obligations to contribute as provided in this Section
7(d) are several in proportion to their respective purchase obligations and not
joint.

         (e) The Initial Purchasers severally confirm that the statements (i)
with respect to the offering of the Notes set forth on the cover page of the
Offering Memorandum, (ii) in the fourth paragraph under "Plan of Distribution",
(iii) in the first paragraph under the heading "Plan of
Distribution--Commissions and Discounts" in the Offering Memorandum; (iv) in the
paragraph under the heading "Plan of Distribution--Notes Are Not Being
Registered" in the Offering Memorandum; (v) in the third and fourth sentences of
the first paragraph under the heading "Plan of Distribution--New Issue of Notes"
in the Offering Memorandum; and (vi) in the first and third sentences of the
first paragraph under the heading "Plan of Distribution--Price Stabilization and
Short Positions" in the Offering Memorandum are correct and constitute the only
information furnished in writing to the Company by or on behalf of the Initial
Purchasers specifically for inclusion in the Offering Memorandum.

8.   DEFAULTING INITIAL PURCHASERS.

         If, on any Delivery Date, any Initial Purchaser defaults in the
performance of its obligations under this Agreement, the remaining
non-defaulting Initial Purchasers shall be obligated to purchase the aggregate
principal amount of Notes which the defaulting Initial Purchaser agreed but
failed to purchase on such Delivery Date in the respective proportions which the
total aggregate principal amount of Notes set opposite the name of each
remaining non-defaulting Initial Purchaser in Schedule 1 hereto bears to the
total aggregate principal amount of Notes set opposite the names of all the
remaining non-defaulting Initial Purchasers in Schedule 1 hereto; PROVIDED,
HOWEVER, that the remaining non-defaulting Initial Purchasers shall not be
obligated to purchase any Notes on such Delivery Date if the total aggregate
principal amount of Notes which the defaulting Initial Purchasers agreed but
failed to purchase on such date exceeds 9.09% of the total aggregate principal
amount at maturity of Notes to be purchased on such Delivery Date, and any
remaining non-defaulting Initial Purchaser shall not be obligated to purchase
more than 110% of the aggregate principal amount at maturity of Notes which it
agreed to purchase on such Delivery Date pursuant to the terms of Section 2. If
the foregoing maximums are exceeded, the remaining non-defaulting Initial
Purchasers, or those other purchasers satisfactory to the Initial Purchasers who
so agree, shall have the right, but shall not be obligated, to purchase on such
Delivery Date, in such proportion as may be agreed upon among them, the total
aggregate principal amount of Notes to be purchased on such Delivery



                                       27
<PAGE>


Date. If the remaining Initial Purchasers or other purchasers satisfactory to
the Initial Purchasers do not elect to purchase on such Delivery Date the
aggregate principal amount of Notes which the defaulting Initial Purchasers
agreed but failed to purchase, this Agreement (or with respect to the Optional
Delivery Date, the obligation of the Initial Purchasers to purchase the Optional
Notes) shall terminate without liability on the part of any non-defaulting
Initial Purchasers and the Company, except that the Company will continue to be
liable for the payment of expenses to the extent set forth in Sections 4 and 10.
As used in this Agreement, the term "Initial Purchaser" includes, for all
purposes of this Agreement unless the context requires otherwise, any party not
listed in Schedule 1 hereto who, pursuant to this Section 8, purchases Notes
which a defaulting Initial Purchaser agreed but failed to purchase.

         Nothing contained herein shall relieve a defaulting Initial Purchaser
of any liability it may have to the Company for damages caused by its default.
If other purchasers are obligated or agree to purchase the Notes of a defaulting
or withdrawing Initial Purchaser, either the remaining non-defaulting Initial
Purchasers or the Company may postpone the Delivery Date for up to seven full
business days in order to effect any changes in the Offering Memorandum or in
any other document or arrangement that, in the opinion of counsel to the Company
or counsel to the Initial Purchasers, may be necessary.

9.   TERMINATION.

         (a) The obligations of the Initial Purchasers hereunder may be
terminated by the Initial Purchasers by notice given to and received by the
Company prior to delivery of and payment for the Notes if, prior to that time:
(i) there has occurred one of the events described in Section 5(L), or (ii)
there has occurred any material adverse change in the financial markets in the
United States, any outbreak of hostilities or escalation thereof or other
calamity or crisis or any change or development involving a prospective change
in national or international political, financial or economic conditions, in
each case the effect of which is such as to make it, in the judgment of the
Representatives, impracticable to market the Notes or to enforce contracts for
the sale of the Notes, or (iii) trading in any securities of the Company has
been suspended or materially limited by the Commission or the Nasdaq National
Market, or if trading generally on the American Stock Exchange or the New York
Stock Exchange or in The Nasdaq Stock Market has been suspended or materially
limited, or minimum or maximum prices for trading have been fixed, or maximum
ranges for prices have been required, by any of said exchanges or by such system
or by order of the Commission, the National Association of Securities Dealers,
Inc. or any other governmental authority, or (iv) a banking moratorium has been
declared by either Federal or New York authorities.

         (b) If this Agreement is terminated pursuant to this Section 9, such
termination shall be without liability of any party to any other party except as
provided in Section 10.

10. REIMBURSEMENT OF INITIAL PURCHASERS' EXPENSES. If (a) the Company shall fail
to tender the Notes for delivery to the Initial Purchasers for any reason
permitted under this Agreement or (b) the Initial Purchasers shall decline to
purchase the Notes for any reason permitted under this Agreement (including the
termination of this Agreement pursuant to Section 9), the Company



                                       28
<PAGE>


shall reimburse the Initial Purchasers for the fees and expenses of their
counsel and for such other out-of-pocket expenses as shall have been incurred by
them in connection with this Agreement and the proposed purchase of the Notes,
and upon demand the Company shall pay the full amount thereof to the Initial
Purchasers. If this Agreement is terminated pursuant to Section 8 by reason of
the default of one or more Initial Purchasers, the Company shall not be
obligated to reimburse any defaulting Initial Purchaser on account of those
expenses.

11. NOTICES, ETC. All statements, requests, notices and agreements hereunder
shall be in writing, and:

         (a) if to the Initial Purchasers, shall be delivered or sent by mail,
telex or facsimile transmission to c/o Merrill Lynch & Co., North Tower, World
Financial Center, New York, New York 10281, Attention: Paul A. Pepe (Fax:
212-738-1069); and

         (b) if to the Company, shall be delivered or sent by mail, telex or
facsimile transmission to Inhale Therapeutic Systems, Inc., 150 Industrial Road,
San Carlos, California 94070, Attention: Stephen L. Hurst, Esq.
(Fax: 650-631-3150).

PROVIDED, HOWEVER, that any notice to an Initial Purchaser pursuant to Section
7(c) shall be delivered or sent by mail, telex or facsimile transmission to each
such Initial Purchaser, which address will be supplied to any other party hereto
by Lehman Brothers Inc. upon request. Any such statements, requests, notices or
agreements shall take effect at the time of receipt thereof. The Company shall
be entitled to act and rely upon any request, consent, notice or agreement given
or made on behalf of the Initial Purchasers by Merrill Lynch.

12. PERSONS ENTITLED TO BENEFIT OF AGREEMENT. This Agreement shall inure to the
benefit of and be binding upon the Initial Purchasers, the Company and their
respective successors. This Agreement and the terms and provisions hereof are
for the sole benefit of only those persons, except that the representations,
warranties, indemnities and agreements of the Company contained in this
Agreement shall also be deemed to be for the benefit of the officers and
employees of each Initial Purchaser and the person or persons, if any, who
control each Initial Purchaser within the meaning of Section 15 of the
Securities Act and any indemnity agreement of the Initial Purchasers contained
in Section 7(b) of this Agreement shall be deemed to be for the benefit of
directors, officers and employees of the Company, and any person controlling the
Company within the meaning of Section 15 of the Securities Act. Nothing
contained in this Agreement is intended or shall be construed to give any
person, other than the persons referred to in this Section 12, any legal or
equitable right, remedy or claim under or in respect of this Agreement or any
provision contained herein.

13. SURVIVAL. The respective indemnities, representations, warranties and
agreements of the Company and the Initial Purchasers contained in this Agreement
or made by or on behalf of them, respectively, pursuant to this Agreement, shall
survive the delivery of and payment for the Notes and shall remain in full force
and effect, regardless of any termination or cancellation of this Agreement or
any investigation made by or on behalf of any of them or any person controlling
any of them.



                                       29
<PAGE>


14. DEFINITION OF THE TERMS "BUSINESS DAY" AND "SUBSIDIARY". For purposes of
this Agreement, (a) "business day" means any day on which the New York Stock
Exchange, Inc. is open for trading and (b) "subsidiary" has the meaning set
forth in Rule 405 of the rules and regulations promulgated under the Securities
Act.

15. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN
ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

16. COUNTERPARTS. This Agreement may be executed in one or more counterparts
and, if executed in more than one counterpart, the executed counterparts shall
each be deemed to be an original but all such counterparts shall together
constitute one and the same instrument.

17. HEADINGS. The headings herein are inserted for convenience of reference only
and are not intended to be part of, or to affect the meaning or interpretation
of, this Agreement.



                                       30
<PAGE>


         If the foregoing correctly sets forth the agreement between the Company
and the Initial Purchasers, please indicate your acceptance in the space
provided for that purpose below.

                                              Very truly yours,

                                              INHALE THERAPEUTIC SYSTEMS, INC.


                                              By:
                                                 -------------------------------
                                                   Name:
                                                   Title:

Accepted and agreed by:

MERRILL LYNCH & CO.
MERRILL LYNCH, PIERCE, FENNER & SMITH
                      INCORPORATED
DEUTSCHE BANK SECURITIES INC.
LEHMAN BROTHERS INC.
U.S. BANCORP PIPER JAFFRAY INC.

By:   MERRILL LYNCH, PIERCE, FENNER & SMITH
                            INCORPORATED

      By:
         ----------------------------------
             Authorized Representative



                                       31
<PAGE>


                                   SCHEDULE 1

<TABLE>
<CAPTION>

                                                                          PRINCIPAL AMOUNT
      INITIAL PURCHASERS                                                    OF FIRM NOTES
      ------------------                                                    -------------
<S>                                                                          <C>
      Merrill Lynch, Pierce, Fenner & Smith
                     Incorporated ...........................................$66,000,000
      Deutsche Bank Securities Inc...........................................$66,000,000
      Lehman Brothers Inc. ..................................................$48,000,000
      U.S. Bancorp Piper Jaffray Inc.........................................$20,000,000

           Total............................................................$200,000,000
</TABLE>

<PAGE>

                        RESALE REGISTRATION RIGHTS AGREEMENT


                                       among

                         INHALE THERAPEUTIC SYSTEMS, INC.,



                                MERRILL LYNCH & CO.,
                 MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED

                           DEUTSCHE BANK SECURITIES INC.

                                LEHMAN BROTHERS INC.

                                        and

                          U.S. BANCORP PIPER JAFFRAY INC.






                            Dated as of February 8, 2000



<PAGE>

     Resale Registration Rights Agreement (the "Agreement"), dated as of
February 8, 2000 among Inhale Therapeutic Systems, Inc., a Delaware corporation
(together with any successor entity, herein referred to as the "Issuer"),
Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner & Smith Incorporated,
Deutsche Bank Securities Inc., Lehman Brothers Inc., and U.S. Bancorp Piper
Jaffray Inc. (collectively, the "Initial Purchasers").

     Pursuant to the Purchase Agreement, dated February 2, 2000, between the
Issuer and the Initial Purchasers (the "Purchase Agreement"), the Initial
Purchasers have agreed to purchase from the Issuer up to $200,000,000
($230,000,000 if the Initial Purchasers exercise the over-allotment option in
full) in aggregate principal amount of 5% Convertible Subordinated Notes due
2007 (the "Notes").  The Notes will be convertible into fully paid,
nonassessable common stock, par value $.0001 per share, of the Issuer  (the
"Common Stock") on the terms, and subject to the conditions, set forth in the
Indenture (as defined herein).  To induce the Initial Purchasers to purchase the
Notes, the Issuer has agreed to provide the registration rights set forth in
this Agreement pursuant to Section 3(l) of the Purchase Agreement.

     The parties hereby agree as follows:

     1.   DEFINITIONS.  As used in this Agreement, the following capitalized
terms shall have the following meanings:

     ADVICE:  As defined in Section 4(c)(ii) hereof.

     AGREEMENT:  As defined in the preamble hereto.

     BLUE SKY APPLICATION:  As defined in Section 6(a) hereof.

     BROKER-DEALER:  Any broker or dealer registered under the Exchange Act.

     BUSINESS DAY:  A day other than a Saturday or Sunday or any federal holiday
in the United States.

     CLOSING DATE:  The date of this Agreement.

     COMMISSION:  Securities and Exchange Commission.

     COMMON STOCK:  As defined in the preamble hereto.

     DAMAGES PAYMENT DATE:  Each Interest Payment Date.  For purposes of this
Agreement, if no Notes are outstanding, "Damages Payment Date" shall mean each
February 8 and August 8.

     EFFECTIVENESS PERIOD:  As defined in Section 2(a)(iii) hereof.

     EFFECTIVENESS TARGET DATE:  As defined in Section 2(a)(ii) hereof.

     EXCHANGE ACT:  Securities Exchange Act of 1934, as amended.

                                          1.


<PAGE>

     HOLDER:  A Person who owns, beneficially or otherwise, Transfer Restricted
Securities.

     INDEMNIFIED HOLDER:  As defined in Section 6(a) hereof.

     INDENTURE:  The Indenture, dated as of February 8, 2000, between the Issuer
and  Chase Manhattan Bank and Trust Company, National Association, as trustee
(the "Trustee"), pursuant to which the Notes are to be issued, as such Indenture
is amended, modified or supplemented from time to time in accordance with the
terms thereof.

     INITIAL PURCHASERS:  As defined in the preamble hereto.

     INTEREST PAYMENT DATE:  As defined in the Indenture.

     ISSUER:  As defined in the preamble hereto.

     LIQUIDATED DAMAGES:  As defined in Section 3(a) hereof.

     MAJORITY OF HOLDERS:  Holders holding over 50% of the aggregate principal
amount of Notes outstanding; provided that, for purpose of this definition, a
holder of shares of Common Stock which constitute Transfer Restricted Securities
and were issued upon conversion of the Notes shall be deemed to hold an
aggregate principal amount of Notes (in addition to the aggregate principal
amount of Notes held by such holder) equal to the aggregate principal amount of
Notes converted by such Holder into such shares of Common Stock.

     NASD:  National Association of Securities Dealers, Inc.

     NOTES:  As defined in the preamble hereto.

     PERSON:  An individual, partnership, corporation, unincorporated
organization, trust, joint venture or a government or agency or political
subdivision thereof.

     PROSPECTUS:  The prospectus included in a Shelf Registration Statement, as
amended or supplemented by any prospectus supplement and by all other amendments
thereto, including post-effective amendments, and all material incorporated by
reference into such Prospectus.

     QUESTIONNAIRE DEADLINE:  As defined in Section 2(b) hereof.

     RECORD HOLDER:  With respect to any Damages Payment Date, each Person who
is a Holder on the record date with respect to the Interest Payment Date on
which such Damages Payment Date shall occur.  In the case of a Holder of shares
of Common Stock issued upon conversion of the Notes, "Record Holder" shall mean
each Person who is a Holder of shares of Common Stock which constitute Transfer
Restricted Securities on the January 24 or July 24 immediately preceding the
Damages Payment Date.

     REGISTRATION DEFAULT:  As defined in Section 3(a) hereof.


                                          2.

<PAGE>

     SALE NOTICE:  As defined in Section 4(e) hereof.

     SECURITIES ACT:  Securities Act of 1933, as amended.

     SHELF FILING DEADLINE: As defined in Section 2(a)(i) hereof.

     SHELF REGISTRATION STATEMENT:  As defined in Section 2(a)(i) hereof.

     SUSPENSION PERIOD.  As defined in Section 4(b)(i) hereof.

     TIA:  Trust Indenture Act of 1939, as in effect on the date the Indenture
is qualified under the TIA.

     TRANSFER RESTRICTED SECURITIES:  Each Note and each share of Common Stock
issued upon conversion of Notes until the earlier of:

          (i)   the date on which such Note or such share of Common Stock issued
     upon conversion has been effectively registered under the Securities Act
     and disposed of in accordance with the Shelf Registration Statement;

          (ii)  the date on which such Note or such share of Common Stock issued
     upon conversion is transferred in compliance with Rule 144 under the
     Securities Act or may be sold or transferred pursuant to Rule 144 under the
     Securities Act (or any other similar provision then in force); or

          (iii) the date on which such Note or such share of Common Stock issued
     upon conversion ceases to be outstanding (whether as a result of
     redemption, repurchase and cancellation, conversion or otherwise).

     UNDERWRITTEN REGISTRATION OR UNDERWRITTEN OFFERING:  A registration in
which securities of the Issuer are sold to an underwriter for reoffering to the
public.

     2.   SHELF REGISTRATION.

     (a)  The Issuer shall:

          (i)   not later than 90 days after the date hereof (the "Shelf Filing
     Deadline"), cause to be filed a registration statement pursuant to Rule 415
     under the Securities Act (the "Shelf Registration Statement"), which Shelf
     Registration Statement shall provide for resales of all Transfer Restricted
     Securities held by Holders that have provided the information required
     pursuant to the terms of Section 2(b) hereof;

          (ii)  use its best efforts to cause the Shelf Registration Statement
     to be declared effective by the Commission as promptly as reasonably
     practicable, but in no event later than 180 days after the date hereof (the
     "Effectiveness Target Date"); and


                                          3.


<PAGE>

          (iii) use its best efforts to keep the Shelf Registration Statement
     continuously effective, supplemented and amended as required by the
     provisions of Section 4(b) hereof to the extent necessary to ensure that
     (A) it is available for resales by the Holders of Transfer Restricted
     Securities entitled to the benefit of this Agreement and (B) conforms with
     the requirements of this Agreement and the Securities Act and the rules and
     regulations of the Commission promulgated thereunder as announced from time
     to time for a period (the "Effectiveness Period") of:

                (1) two years following the last date of original issuance of
          Notes; or

                (2) such shorter period that will terminate when (x) all of the
          Holders of Transfer Restricted Securities are able to sell all
          Transfer Restricted Securities immediately without restriction
          pursuant to Rule 144(k) under the Securities Act or any successor rule
          thereto, (y) when all Transfer Restricted Securities have ceased to be
          outstanding (whether as a result of redemption, repurchase and
          cancellation, conversion or otherwise) or (z) all Transfer Restricted
          Securities registered under the Shelf Registration Statement have been
          sold.

     (b)  No Holder of Transfer Restricted Securities may include any of its
Transfer Restricted Securities in the Shelf Registration Statement pursuant to
this Agreement unless such Holder furnishes to the Issuer in writing, prior to
or on the 20th Business Day after receipt of a request therefor (the
"Questionnaire Deadline"), such information as the Issuer may reasonably request
for use in connection with the Shelf Registration Statement or the Prospectus or
preliminary Prospectus included therein and in any application to be filed with
or under state securities laws.  In connection with all such requests for
information from Holders of Transfer Restricted Securities, the Issuer shall
notify such Holders of the requirements set forth in the preceding sentence.  No
Holder of Transfer Restricted Securities shall be entitled to Liquidated Damages
pursuant to Section 3 hereof unless such Holder shall have provided all such
reasonably requested information prior to or on the Questionnaire Deadline.
Each Holder as to which the Shelf Registration Statement is being effected
agrees to furnish promptly to the Issuer all information required to be
disclosed in order to make information previously furnished to the Issuer by
such Holder not materially misleading.

     3.   LIQUIDATED DAMAGES.

     (a)  If:

          (i)   the Shelf Registration Statement is not filed with the
     Commission prior to or on the Shelf Filing Deadline;

          (ii)  the Shelf Registration Statement has not been declared effective
     by the Commission prior to or on the Effective Target Date;

          (iii) subject to the provisions of Section 4(b)(i) hereof, the Shelf
     Registration Statement is filed and declared effective but, during the
     Effectiveness Period, shall thereafter cease to be effective or fail to be
     usable for its intended purpose without being succeeded within five
     Business Days by a post-effective amendment to the Shelf Registration
     Statement or a report filed with the Commission pursuant to Section 13(a),


                                          4.

<PAGE>

     13(c), 14 or 15(d) of the Exchange Act that cures such failure and, in the
     case of a post-effective amendment, is itself immediately declared
     effective; or

          (iv)  prior to or on the 45th or 60th day, as the case may be, of any
     Suspension Period, such suspension has not been terminated,

     (each such event referred to in foregoing clauses (i) through (iv), a
     "Registration Default"), the Issuer hereby agrees to pay liquidated damages
     ("Liquidated Damages") with respect to the Transfer Restricted Securities
     from and including the day following the Registration Default to but
     excluding the day on which the Registration Default has been cured:

                (A) in respect of the Notes, to each holder of Notes, (x) with
          respect to the first 90-day period during which a Registration Default
          shall have occurred and be continuing, in an amount per year equal to
          an additional 0.25% of the principal amount of the Notes, and (y) with
          respect to the period commencing on the 91st day following the day the
          Registration Default shall have occurred and be continuing, in an
          amount per year equal to an additional 0.50% of the principal amount
          of the Notes; provided that in no event shall Liquidated Damages
          accrue at a rate per year exceeding 0.50% of the principal amount of
          the Notes; and

                (B) in respect of any shares of Common Stock, to each holder of
          shares of Common Stock issued upon conversion of Notes, (x) with
          respect to the first 90-day period in which a Registration Default
          shall have occurred and be continuing, in an amount per year equal to
          0.25% of the principal amount of the converted Notes, and (y) with
          respect to the period commencing the 91st day following the day the
          Registration Default shall have occurred and be continuing, in an
          amount per year equal to 0.50% of the principal amount of the
          converted Notes; provided that in no event shall Liquidated Damages
          accrue at a rate per year exceeding 0.50% of the principal amount of
          the converted Notes.

     (b)  All accrued Liquidated Damages shall be paid in arrears to Record
Holders by the Issuer on each Damages Payment Date by wire transfer of
immediately available funds or by federal funds check.  Following the cure of
all Registration Defaults relating to any particular Note or share of Common
Stock, the accrual of Liquidated Damages with respect to such Note or share of
Common Stock will cease.

     All obligations of the Issuer set forth in this Section 3 that are
outstanding with respect to any Transfer Restricted Security at the time such
security ceases to be a Transfer Restricted Security shall survive until such
time as all such obligations with respect to such Transfer Restricted Security
shall have been satisfied in full.

     The Liquidated Damages set forth above shall be the exclusive monetary
remedy available to the Holders of Transfer Restricted Securities for such
Registration Default.

     4.   REGISTRATION PROCEDURES.


                                          5.

<PAGE>

     (a)  In connection with the Shelf Registration Statement, the Issuer shall
comply with all the provisions of Section 4(b) hereof and shall use its best
efforts to effect such registration to permit the sale of the Transfer
Restricted Securities being sold in accordance with the intended method or
methods of distribution thereof, and pursuant thereto, shall as expeditiously as
possible prepare and file with the Commission a Shelf Registration Statement
relating to the registration on any appropriate form under the Securities Act.

     (b)  In connection with the Shelf Registration Statement and any Prospectus
required by this Agreement to permit the sale or resale of Transfer Restricted
Securities, the Issuer shall:

          (i)   Subject to any notice by the Issuer in accordance with this
     Section 4(b) of the existence of any fact or event of the kind described in
     Section 4(b)(iii)(D), use its best efforts to keep the Shelf Registration
     Statement continuously effective during the Effectiveness Period; upon the
     occurrence of any event that would cause the Shelf Registration Statement
     or the Prospectus contained therein (A) to contain a material misstatement
     or omission or (B) not be effective and usable for resale of Transfer
     Restricted Securities during the Effectiveness Period, the Issuer shall
     file promptly an appropriate amendment to the Shelf Registration Statement
     or a report filed with the Commission pursuant to Section 13(a), 13(c), 14
     or 15(d) of the Exchange Act, in the case of clause (A), correcting any
     such misstatement or omission, and, in the case of either clause (A) or
     (B), use its best efforts to cause such amendment to be declared effective
     and the Shelf Registration Statement and the related Prospectus to become
     usable for their intended purposes as soon as practicable thereafter.
     Notwithstanding the foregoing, the Issuer may suspend the effectiveness of
     the Shelf Registration Statement by written notice to the Holders for a
     period not to exceed an aggregate of 45 days in any 90-day period (each
     such period, a "Suspension Period") if:

                (x)   an event occurs and is continuing as a result of which the
          Shelf Registration Statement would, in the Issuer's reasonable
          judgment, contain an untrue statement of a material fact or omit to
          state a material fact required to be stated therein or necessary to
          make the statements therein not misleading; and

                (y)   the Issuer reasonably determines that the disclosure of
          such event at such time would have a material adverse effect on the
          business of the Issuer (and its subsidiaries, if any, taken as a
          whole);

PROVIDED that in the event the disclosure relates to a previously undisclosed
proposed or pending material business transaction, the disclosure of which would
impede the Issuer's ability to consummate such transaction, the Issuer may
extend a Suspension Period from 45 days to 60 days; provided, however, that
Suspension Periods shall not exceed an aggregate of 90 days in any 360-day
period.

          (ii)  Prepare and file with the Commission such amendments and
     post-effective amendments to the Shelf Registration Statement as may be
     necessary to keep the Shelf Registration Statement effective during the
     Effectiveness Period; cause the Prospectus to be supplemented by any
     required Prospectus supplement, and as so supplemented to be filed pursuant
     to Rule 424 under the Securities Act, and to comply fully with the


                                          6.

<PAGE>

     applicable provisions of Rules 424 and 430A under the Securities Act in a
     timely manner; and comply with the provisions of the Securities Act with
     respect to the disposition of all securities covered by the Shelf
     Registration Statement during the applicable period in accordance with the
     intended method or methods of distribution by the sellers thereof set forth
     in the Shelf Registration Statement or supplement to the Prospectus.

          (iii) Advise the underwriter(s), if any, and selling Holders promptly
     (but in any event within five Business Days) and, if requested by such
     Persons, to confirm such advice in writing:

                (A) when the Prospectus or any Prospectus supplement or
          post-effective amendment has been filed, and, with respect to the
          Shelf Registration Statement or any post-effective amendment thereto,
          when the same has become effective,

                (B) of any request by the Commission for amendments to the Shelf
          Registration Statement or amendments or supplements to the Prospectus
          or for additional information relating thereto,

                (C) of the issuance by the Commission of any stop order
          suspending the effectiveness of the Shelf Registration Statement under
          the Securities Act or of the suspension by any state securities
          commission of the qualification of the Transfer Restricted Securities
          for offering or sale in any jurisdiction, or the initiation of any
          proceeding for any of the preceding purposes, or

                (D) of the existence of any fact or the happening of any event,
          during the Effectiveness Period, that makes any statement of a
          material fact made in the Shelf Registration Statement, the
          Prospectus, any amendment or supplement thereto, or any document
          incorporated by reference therein untrue, or that requires the making
          of any additions to or changes in the Shelf Registration Statement or
          the Prospectus in order to make the statements therein not misleading.

If at any time the Commission shall issue any stop order suspending the
effectiveness of the Shelf Registration Statement, or any state securities
commission or other regulatory authority shall issue an order suspending the
qualification or exemption from qualification of the Transfer Restricted
Securities under state securities or Blue Sky laws, the Issuer shall use its
reasonable best efforts to obtain the withdrawal or lifting of such order at the
earliest possible time.

          (iv)  Furnish to each of the selling Holders and each of the
     underwriter(s), if any, before filing with the Commission, a copy of the
     Shelf Registration Statement and copies of any Prospectus included therein
     or any amendments or supplements to the Shelf Registration Statement or
     Prospectus (other than documents incorporated by reference after the
     initial filing of the Shelf Registration Statement), which documents will
     be subject to the review of such holders and underwriter(s), if any, for a
     period of at least ten Business Days, and the Issuer will not file any
     Shelf Registration Statement or Prospectus or any amendment or supplement
     to the Shelf Registration Statement or Prospectus (other than documents
     incorporated by reference) to which a selling Holder of Transfer


                                          7.

<PAGE>

     Restricted Securities covered by the Shelf Registration Statement or the
     underwriter(s), if any, shall reasonably object within five Business Days
     after the receipt thereof.  A selling Holder or underwriter, if any, shall
     be deemed to have reasonably objected to such filing if the Shelf
     Registration Statement, amendment, Prospectus or supplement, as applicable,
     as proposed to be filed, contains a material misstatement or omission.
     Notwithstanding the foregoing, the Issuer shall not be required to furnish
     the selling Holders with any amendment or supplement to the Shelf
     Registration Statement or Prospectus filed solely to reflect changes to the
     amount of Notes held by any particular Holder at the request of such Holder
     or immaterial revisions to the information contained therein.

          (v)   Make available at reasonable times for inspection by one or more
     representatives of the selling Holders, designated in writing by a Majority
     of Holders whose Transfer Restricted Securities are included in the Shelf
     Registration Statement, any underwriter participating in any distribution
     pursuant to the Shelf Registration Statement, and any attorney or
     accountant retained by such selling Holders or any of the underwriter(s),
     all financial and other records, pertinent corporate documents and
     properties of the Issuer as shall be reasonably necessary to enable them to
     exercise any applicable due diligence responsibilities, and cause the
     Issuer's officers, directors, managers and employees to supply all
     information reasonably requested by any such representative or
     representatives of the selling Holders, underwriter, attorney or accountant
     in connection with the Shelf Registration Statement after the filing
     thereof and before its effectiveness; provided, however, that any
     information designated by the Company as confidential at the time of
     delivery of such information shall be kept confidential by the recipient
     thereof.

          (vi)  If requested by any selling Holders or the underwriter(s), if
     any, promptly incorporate in the Shelf Registration Statement or
     Prospectus, pursuant to a supplement or post-effective amendment if
     necessary, such information as such selling Holders and underwriter(s), if
     any, may reasonably request to have included therein, including, without
     limitation: (1) information relating to the "Plan of Distribution" of the
     Transfer Restricted Securities, (2) information with respect to the
     principal amount of Notes or number of shares of Common Stock being sold to
     such underwriter(s), (3) the purchase price being paid therefor and (4) any
     other terms of the offering of the Transfer Restricted Securities to be
     sold in such offering; and make all required filings of such Prospectus
     supplement or post-effective amendment as soon as reasonably practicable
     after the Issuer is notified of the matters to be incorporated in such
     Prospectus supplement or post-effective amendment.  Notwithstanding the
     foregoing, following the effective date of the Shelf Registration
     Statement, the Issuer shall not be required to file more than one such
     supplement or post-effective amendment to reflect changes in the amount of
     Notes held by any particular Holder at the request of such Holder in any
     30-day period.

          (vii) Furnish to each selling Holder and each of the underwriter(s),
     if any, without charge, at least one copy of the Shelf Registration
     Statement, as first filed with the Commission, and of each amendment
     thereto (and any documents incorporated by reference therein or exhibits
     thereto (or exhibits incorporated in such exhibits by reference) as such
     Person may request).


                                          8.

<PAGE>

          (viii) Deliver to each selling Holder and each of the underwriter(s),
     if any, without charge, as many copies of the Prospectus (including each
     preliminary prospectus) and any amendment or supplement thereto as such
     Persons reasonably may request; subject to any notice by the Issuer in
     accordance with this Section 4(b) of the existence of any fact or event of
     the kind described in Section 4(b)(iii)(D), the Issuer hereby consents to
     the use of the Prospectus and any amendment or supplement thereto by each
     of the selling Holders and each of the underwriter(s), if any, in
     connection with  the offering and the sale of the Transfer Restricted
     Securities covered by the Prospectus or any amendment or supplement
     thereto.

          (ix)   If  an underwriting agreement is entered into and the
     registration is an Underwritten Registration, the Issuer shall:

                 (A)     upon request, furnish to each selling Holder and each
          underwriter, if any, in such substance and scope as they may
          reasonably request and as are customarily made by issuers to
          underwriters in primary underwritten offerings, upon the date of
          closing of any sale of Transfer Restricted Securities in an
          Underwritten Registration:

                    (1)  a certificate, dated the date of such closing, signed
                 by the Chief Financial Officer of the Issuer confirming, as of
                 the date thereof, the matters set forth in Section 5(g) of the
                 Purchase Agreement and such other matters as such parties may
                 reasonably request;

                    (2)  opinions, each dated the date of such closing, of
                 counsel to the Issuer covering such of the matters set forth in
                 Sections 5(c) and 5(d) of the Purchase Agreement as are
                 customarily covered in legal opinions to underwriters in
                 connection with primary underwritten offerings of securities;
                 and

                    (3)  customary comfort letters, dated the date of such
                 closing, from the Issuer's independent certified public
                 accountants (and from any other accountants whose report is
                 contained or incorporated by reference in the Shelf
                 Registration Statement), in the customary form and covering
                 matters of the type customarily covered in comfort letters to
                 underwriters in connection with primary underwritten offerings
                 of securities;

                (B) set forth in full in the underwriting agreement, if any,
          indemnification provisions and procedures which provide rights no less
          protective than those set forth in Section 6 hereof with respect to
          all parties to be indemnified; and

                (C) deliver such other documents and certificates as may be
          reasonably requested by such parties to evidence compliance with
          clause (A) above and with any customary conditions contained in the
          underwriting agreement or other agreement entered into by the selling
          Holders pursuant to this clause (ix).


                                          9.

<PAGE>

          (x)   Before any public offering of Transfer Restricted Securities,
     cooperate with the selling Holders, the underwriter(s), if any, and their
     respective counsel in connection with the registration and qualification of
     the Transfer Restricted Securities under the securities or Blue Sky laws of
     such jurisdictions as the selling Holders or underwriter(s), if any, may
     reasonably request and do any and all other acts or things necessary or
     advisable to enable the disposition in such jurisdictions of the Transfer
     Restricted Securities covered by the Shelf Registration Statement;
     provided, however, that the Issuer shall not be required (A) to register or
     qualify as a foreign corporation or a dealer of securities where it is not
     now so qualified or to take any action that would subject it to the service
     of process in any jurisdiction where it is not now so subject or (B) to
     subject themselves to taxation in any such jurisdiction if they are not now
     so subject.

          (xi)    Cooperate with the selling Holders and the underwriter(s), if
     any, to facilitate the timely preparation and delivery of certificates
     representing Transfer Restricted Securities to be sold and not bearing any
     restrictive legends (unless required by applicable securities laws); and
     enable such Transfer Restricted Securities to be in such denominations and
     registered in such names as the Holders or the underwriter(s), if any, may
     request at least two Business Days before any sale of Transfer Restricted
     Securities made by such underwriter(s).

          (xii)   Use its best efforts to cause the Transfer Restricted
     Securities covered by the Shelf Registration Statement to be registered
     with or approved by such other U.S. governmental agencies or authorities as
     may be necessary to enable the seller or sellers thereof or the
     underwriter(s), if any, to consummate the disposition of such Transfer
     Restricted Securities.

          (xiii)  Subject to Section 4(b)(i) hereof, if any fact or event
     contemplated by Section 4(b)(iii)(D) hereof shall exist or have occurred,
     use its reasonable best efforts to prepare a supplement or post-effective
     amendment to the Shelf Registration Statement or related Prospectus or any
     document incorporated therein by reference or file any other required
     document so that, as thereafter delivered to the purchasers of Transfer
     Restricted Securities, the Prospectus will not contain an untrue statement
     of a material fact or omit to state any material fact required to be stated
     therein or necessary to make the statements therein not misleading.

          (xiv)   Provide CUSIP numbers for all Transfer Restricted Securities
     not later than the effective date of the Shelf Registration Statement and
     provide the Trustee under the Indenture with certificates for the Notes
     that are in a form eligible for deposit with The Depository Trust Company.

          (xv)    Cooperate and assist in any filings required to be made with
     the NASD and in the performance of any due diligence investigation by any
     underwriter that is required to be retained in accordance with the rules
     and regulations of the NASD.

          (xvi)   Otherwise use its best efforts to comply with all applicable
     rules and regulations of the Commission and all reporting requirements
     under the rules and regulations of the Exchange Act.


                                         10.

<PAGE>

          (xvii)  Cause the Indenture to be qualified under the TIA not later
     than the effective date of the Shelf Registration Statement required by
     this Agreement, and, in connection therewith, cooperate with the trustee
     and the holders of Notes to effect such changes to the Indenture as may be
     required for such Indenture to be so qualified in accordance with the terms
     of the TIA; and execute and use its best efforts to cause the trustee
     thereunder to execute all documents that may be required to effect such
     changes and all other forms and documents required to be filed with the
     Commission to enable such Indenture to be so qualified in a timely manner.

          (xviii) Cause all Transfer Restricted Securities covered by the Shelf
     Registration Statement to be listed or quoted, as the case may be, on each
     securities exchange or automated quotation system on which similar
     securities issued by the Issuer are then listed or quoted.

          (xix)   Provide promptly to each Holder upon written request each
     document filed with the Commission pursuant to the requirements of Section
     13 and Section 15 of the Exchange Act after the effective date of the Shelf
     Registration Statement.

          (xx)    If requested by the underwriters, make appropriate officers of
     the Issuer available to the underwriters for meetings with prospective
     purchasers of the Transfer Restricted Securities and prepare and present to
     potential investors customary "road show" material in a manner consistent
     with other new issuances of other securities similar to the Transfer
     Restricted Securities.

     (c)  Each Holder agrees by acquisition of a Transfer Restricted Security
that, upon receipt of any notice from the Issuer of the existence of any fact of
the kind described in Section 4(b)(iii)(D) hereof, such Holder will, and will
use its reasonable best efforts to cause any underwriter(s) in an Underwritten
Offering to, forthwith discontinue disposition of Transfer Restricted Securities
pursuant to the Shelf Registration Statement until:

          (i)     such Holder has received copies of the supplemented or amended
     Prospectus contemplated by Section 4(b)(xiii) hereof; or

          (ii)    such Holder is advised in writing (the "Advice") by the Issuer
     that the use of the Prospectus may be resumed, and has received copies of
     any additional or supplemental filings that are incorporated by reference
     in the Prospectus.

If so directed by the Issuer, each Holder will deliver to the Issuer (at the
Issuer's expense) all copies, other than permanent file copies then in such
Holder's possession, of the Prospectus covering such Transfer Restricted
Securities that was current at the time of receipt of such notice of suspension.

     (d)  Each Holder who intends to be named as a selling Holder in the Shelf
Registration Statement shall furnish to the Issuer in writing, within 20
Business Days after receipt of a request therefor as set forth in a
questionnaire, such information regarding such Holder and the proposed
distribution by such Holder of its Transfer Restricted Securities as the Issuer
may reasonably request for use in connection with the Shelf Registration
Statement or Prospectus or preliminary


                                         11.

<PAGE>

Prospectus included therein.  (The form of the questionnaire is attached hereto
as Exhibit A.)  Holders that do not complete the questionnaire and deliver it to
the Issuer shall not be named as selling securityholders in the Prospectus or
preliminary Prospectus included in the Shelf Registration Statement and
therefore shall not be permitted to sell any Transfer Restricted Securities
pursuant to the Shelf Registration Statement.  Each Holder who intends to be
named as a selling Holder in the Shelf Registration Statement shall promptly
furnish to the Issuer in writing such other information as the Issuer may from
time to time reasonably request in writing.

     (e)  Upon the effectiveness of the Shelf Registration Statement, each
Holder shall notify the Issuer at least three Business Days prior to any
intended distribution of Transfer Restricted Securities pursuant to the Shelf
Registration Statement (a "Sale Notice"), which notice shall be effective for
five Business Days.  Each Holder of this Security, by accepting the same, agrees
to hold any communication by the Company in response to a Sale Notice in
confidence.

     5.   REGISTRATION EXPENSES.

     (a)  All expenses incident to the Issuer's performance of or compliance
with this Agreement shall be borne by the Issuer regardless of whether a Shelf
Registration Statement becomes effective, including, without limitation:

          (i)     all registration and filing fees and expenses (including
     filings made by any Initial Purchasers or Holders with the NASD);

          (ii)    all fees and expenses of compliance with federal securities
     and state Blue Sky or securities laws;

          (iii)   all expenses of printing (including printing of Prospectuses
     and certificates for the Common Stock to be issued upon conversion of the
     Notes), messenger and delivery services and telephone;

          (iv)    all fees and disbursements of counsel to the Issuer and,
     subject to Section 5(b) below, the Holders of Transfer Restricted
     Securities;

          (v)     all application and filing fees in connection with listing (or
     authorizing for quotation) the Common Stock on a national securities
     exchange or automated quotation system pursuant to the requirements hereof;
     and

          (vi)    all fees and disbursements of independent certified public
     accountants of the Issuer (including the expenses of any special audit and
     comfort letters required by or incident to such performance).

     The Issuer shall bear its internal expenses (including, without limitation,
all salaries and expenses of their officers and employees performing legal,
accounting or other duties), the expenses of any annual audit and the fees and
expenses of any Person, including special experts, retained by the Issuer.

     (b)  In connection with the Shelf Registration Statement required by this
Agreement, the Issuer shall reimburse the Initial Purchasers and the Holders of
Transfer Restricted Securities


                                         12.

<PAGE>

being registered pursuant to the Shelf Registration Statement, as applicable,
for the reasonable fees and disbursements of not more than one counsel, which
shall be Brown & Wood LLP, or such other counsel as may be chosen by a Majority
of Holders for whose benefit the Shelf Registration Statement is being prepared.

     6.   INDEMNIFICATION AND CONTRIBUTION.

     (a)  The Issuer shall indemnify and hold harmless each Holder, such
Holder's officers and employees and each person, if any, who controls such
Holder within the meaning of the Securities Act (each, an "Indemnified Holder"),
from and against any loss, claim, damage or liability, joint or several, or any
action in respect thereof (including, but not limited to, any loss, claim,
damage, liability or action relating to resales of the Transfer Restricted
Securities), to which such Indemnified Holder may become subject, insofar as any
such loss, claim, damage, liability or action arises out of, or is based upon:

          (i)     any untrue statement or alleged untrue statement of a material
     fact contained in (A) the Shelf Registration Statement or Prospectus or any
     amendment or supplement thereto or (B) any blue sky application or other
     document or any amendment or supplement thereto prepared or executed by the
     Issuer (or based upon written information furnished by or on behalf of the
     Issuer expressly for use in such blue sky application or other document or
     amendment on supplement) filed in any jurisdiction specifically for the
     purpose of qualifying any or all of the Transfer Restricted Securities
     under the securities law of any state or other jurisdiction (such
     application or document being hereinafter called a "Blue Sky Application");
     or

          (ii)    the omission or alleged omission to state therein any material
     fact required to be stated therein or necessary to make the statements
     therein, in the light of the circumstances under which they were made, not
     misleading,

and shall reimburse each Indemnified Holder promptly upon demand for any legal
or other expenses reasonably incurred by such Indemnified Holder in connection
with investigating or defending or preparing to defend against any such loss,
claim, damage, liability or action as such expenses are incurred; provided,
however, that the Issuer shall not be liable in any such case to the extent that
any such loss, claim, damage, liability or action arises out of, or is based
upon, any untrue statement or alleged untrue statement or omission or alleged
omission made in the Shelf Registration Statement or Prospectus or amendment or
supplement thereto or Blue Sky Application in reliance upon and in conformity
with written information furnished to the Issuer by or on behalf of any Holder
(or its related Indemnified Holder) specifically for use therein.  The foregoing
indemnity agreement is in addition to any liability which the Issuer may
otherwise have to any Indemnified Holder.

     (b)  Each Holder, severally and not jointly, shall indemnify and hold
harmless the Issuer, its officers and employees and each person, if any, who
controls the Issuer within the meaning of the Securities Act, from and against
any loss, claim, damage or liability, joint or several, or any action in respect
thereof, to which the Issuer or any such officer, employee or controlling person
may become subject, insofar as any such loss, claim, damage or liability or
action arises out of, or is based upon:


                                         13.

<PAGE>

          (i)     any untrue statement or alleged untrue statement of any
     material fact contained in the Shelf Registration Statement or Prospectus
     or any amendment or supplement thereto or any Blue Sky Application; or

          (ii)    the omission or the alleged omission to state therein any
     material fact required to be stated therein or necessary to make the
     statements therein, in light of the circumstances under which they were
     made, not misleading,

but in each case only to the extent that such untrue statement or alleged untrue
statement or omission or alleged omission was made in reliance upon and in
conformity with written information furnished to the Issuer by or on behalf of
such Holder (or its related Indemnified Holder) specifically for use therein,
and shall reimburse the Issuer and any such officer, employee or controlling
person promptly upon demand for any legal or other expenses reasonably incurred
by the Issuer or any such officer, employee or controlling person in connection
with investigating or defending or preparing to defend against any such loss,
claim, damage, liability or action as such expenses are incurred.  The foregoing
indemnity agreement is in addition to any liability which any Holder may
otherwise have to the Issuer and any such officer, employee or controlling
person.

     (c)  Promptly after receipt by an indemnified party under this Section 6 of
notice of any claim or the commencement of any action, the indemnified party
shall, if a claim in respect thereof is to be made against the indemnifying
party under this Section 6, notify the indemnifying party in writing of the
claim or the commencement of that action; provided, however, that the failure to
notify the indemnifying party shall not relieve it from any liability which it
may have under this Section 6 except to the extent it has been materially
prejudiced by such failure and, provided, further, that the failure to notify
the indemnifying party shall not relieve it from any liability which it may have
to an indemnified party otherwise than under this Section 6.  If any such claim
or action shall be brought against an indemnified party, and it shall notify the
indemnifying party thereof, the indemnifying party shall be entitled to
participate therein and, to the extent that it wishes, jointly with any other
similarly notified indemnifying party, to assume the defense thereof with
counsel satisfactory to the indemnified party.  After notice from the
indemnifying party to the indemnified party of its election to assume the
defense of such claim or action, the indemnifying party shall not be liable to
the indemnified party under this Section 6 for any legal or other expenses
subsequently incurred by the indemnified party in connection with the defense
thereof other than reasonable costs of investigation; provided, however, that a
Majority of Holders shall have the right to employ a single counsel to represent
jointly a Majority of Holders and their respective officers, employees and
controlling persons who may be subject to liability arising out of any claim in
respect of which indemnity may be sought by a Majority of Holders against the
Issuer under this Section 6, if a Majority of Holders shall have reasonably
concluded that there may be one or more legal defenses available to them and
their respective officers, employees and controling persons that are different
from or additional to those available to the Issuer and its officers, employees
and controlling persons, the fees and expenses of a single separate counsel
shall be paid by the Issuer.  No indemnifying party shall:


                                         14.

<PAGE>

          (i)     without the prior written consent of the indemnified parties
     (which consent shall not be unreasonably withheld) settle or compromise or
     consent to the entry of any judgment with respect to any pending or
     threatened claim, action, suit or proceeding in respect of which
     indemnification or contribution may be sought hereunder (whether or not the
     indemnified parties are actual or potential parties to such claim or
     action) unless such settlement, compromise or consent includes an
     unconditional release of each indemnified party from all liability arising
     out of such claim, action, suit or proceeding, or

          (ii)    be liable for any settlement of any such action effected
     without its written consent (which consent shall not be unreasonably
     withheld), but if settled with its written consent or if there be a final
     judgment for the plaintiff in any such action, the indemnifying party
     agrees to indemnify and hold harmless any indemnified party from and
     against any loss of liability by reason of such settlement or judgment.

     (d)  If the indemnification provided for in this Section 6 shall for any
reason be unavailable or insufficient to hold harmless an indemnified party
under Section 6(a) or 6(b) in respect of any loss, claim, damage or liability
(or action in respect thereof) referred to therein, each indemnifying party
shall, in lieu of indemnifying such indemnified party, contribute to the amount
paid or payable by such indemnified party as a result of such loss, claim,
damage or liability (or action in respect thereof):

          (i)     in such proportion as is appropriate to reflect the relative
     benefits received by the Issuer from the offering and sale of the Transfer
     Restricted Securities on the one hand and a Holder with respect to the sale
     by such Holder of the Transfer Restricted Securities on the other, or

          (ii)    if the allocation provided by clause (6)(d)(i) is not
     permitted by applicable law, in such proportion as is appropriate to
     reflect not only the relative benefits referred to in clause 6(d)(i) but
     also the relative fault of the Issuer on the one hand and the Holders on
     the other in connection with the statements or omissions or alleged
     statements or alleged omissions that resulted in such loss, claim, damage
     or liability (or action in respect thereof), as well as any other relevant
     equitable considerations.


The relative benefits received by the Issuer on the one hand and a Holder on the
other with respect to such offering and such sale shall be deemed to be in the
same proportion as the total net proceeds from the offering of the Notes
purchased under the Purchase Agreement (before deducting expenses) received by
the Issuer as set forth in the table on the cover of the Offering Memorandum,
dated February 2, 2000, on the one hand, bear to the total proceeds received by
such Holder with respect to its sale if Transfer Restricted Securities on the
other.  The relative fault of the parties shall be determined by reference to
whether the untrue or alleged untrue statement of a material fact or the
omission or alleged omission to state a material fact relates to information
supplied by the Issuer on the one hand or the Holders on the other, the intent
of the parties and their relative knowledge, access to information and
opportunity to correct or prevent such statement or omission.  The Issuer and
each Holder agree that it would not be just and equitable if the amount of
contribution pursuant to this Section 6(d) were determined by pro rata


                                         15.

<PAGE>

allocation or by any other method of allocation that does not take into account
the equitable considerations referred to in the first sentence of this paragraph
(d).  The amount paid or payable by an indemnified party as a result of the
loss, claim, damage or liability, or action in respect thereof, referred to
above in this Section 6 shall be deemed to include, for purposes of this Section
6, any legal or other expenses reasonably incurred by such indemnified party in
connection with investigating or defending or preparing to defend any such
action or claim.  Notwithstanding the provisions of this Section 6, no Holder
shall be required to contribute any amount in excess of the amount by which the
total price at which the Transfer Restricted Securities purchased by it were
resold exceeds the amount of any damages which such Holder has otherwise been
required to pay by reason of any untrue or alleged untrue statement or omission
or alleged omission.  No person guilty of fraudulent misrepresentation (within
the meaning of Section 11(f) of the Securities Act) shall be entitled to
contribution from any person who was not guilty of such fraudulent
misrepresentation.  The Holders' obligations to contribute as provided in this
Section 6(d) are several and not joint.

     7.   RULE 144A.  In the event the Issuer is not subject to Section 13 or
15(d) of the Exchange Act, the Issuer hereby agrees with each Holder, for so
long as any Transfer Restricted Securities remain outstanding, to make available
to any Holder or beneficial owner of Transfer Restricted Securities in
connection with any sale thereof and any prospective purchaser of such Transfer
Restricted Securities from such Holder or beneficial owner, the information
required by Rule 144A(d)(4) under the Securities Act in order to permit resales
of such Transfer Restricted Securities pursuant to Rule 144A.

     8.   PARTICIPATION IN UNDERWRITTEN REGISTRATIONS.  No Holder may
participate in any Underwritten Registration hereunder unless such Holder:

          (i)     agrees to sell such Holder's Transfer Restricted Securities on
     the basis provided in any underwriting arrangements approved by the Persons
     entitled hereunder to approve such arrangements and

          (ii)    completes and executes all reasonable questionnaires, powers
     of attorney, indemnities, underwriting agreements, lock-up letters and
     other documents required under the terms of such underwriting arrangements.

     9.   SELECTION OF UNDERWRITERS.  The Holders of Transfer Restricted
Securities covered by the Shelf Registration Statement who desire to do so may
sell such Transfer Restricted Securities in an Underwritten Offering.  In any
such Underwritten Offering, the investment banker or investment bankers and
manager or managers that will administer the offering will be selected by a
Majority of Holders whose Transfer Restricted Securities are included in such
offering; provided, that such investment bankers and managers must be reasonably
satisfactory to the Issuer.

     10.  MISCELLANEOUS.

     (a)  REMEDIES.  The Issuer acknowledges and agrees that any failure by the
Issuer to comply with its obligations under Section 2 hereof may result in
material irreparable injury to the Initial Purchasers or the Holders for which
there is no adequate remedy at law, that it will not be


                                         16.

<PAGE>

possible to measure damages for such injuries precisely and that, in the event
of any such failure, the Initial Purchasers or any Holder may obtain such relief
as may be required to specifically enforce the Issuer's obligations under
Section 2 hereof.  The Issuer further agrees to waive the defense in any action
for specific performance that a remedy at law would be adequate.

     (b)  ADJUSTMENTS AFFECTING TRANSFER RESTRICTED SECURITIES.  The Issuer
shall not, directly or indirectly, take any action with respect to the Transfer
Restricted Securities as a class that would adversely affect the ability of the
Holders of Transfer Restricted Securities to include such Transfer Restricted
Securities in a registration undertaken pursuant to this Agreement.

     (c)  NO INCONSISTENT AGREEMENTS. The Issuer will not, on or after the date
of this Agreement, enter into any agreement with respect to its securities that
is inconsistent with the rights granted to the Holders in this Agreement or
otherwise conflicts with the provisions hereof.  In addition, the Issuer shall
not grant to any of its security holders (other than the holders of Transfer
Restricted Securities in such capacity) the right to include any of its
securities in the Shelf Registration Statement provided for in this Agreement
other than the Transfer Restricted Securities.  Other than the Stock Purchase
Agreement, dated January 18, 1995, between the Issuer and Pfizer, Inc., the
Stock Purchase Agreement, dated March 1, 1996, as amended, between the Issuer
and Baxter Healthcare Corporation and the Stock Issuance Agreement, dated
November 4, 1999, between the Issuer and Alliance Pharmaceutical Corp., the
Issuer has not previously entered into any agreement (which has not expired or
been terminated) granting any registration rights with respect to its securities
to any Person which rights conflict with the provisions hereof.

     (d)  AMENDMENTS AND WAIVERS. This Agreement may not be amended, modified or
supplemented, and waivers or consents to or departures from the provisions
hereof may not be given, unless the Issuer has obtained the written consent of a
Majority of Holders.

     (e)  NOTICES. All notices and other communications provided for or
permitted hereunder shall be made in writing by hand-delivery, first-class mail
(registered or certified, return receipt requested), telex, telecopier, or air
courier guaranteeing overnight delivery:

          (i)     if to a Holder, at the address set forth on the records of the
     registrar under the Indenture or the transfer agent of the Common Stock, as
     the case may be; and

          (ii)    if to the Issuer:

                         Inhale Therapeutic Systems, Inc.
                         150 Industrial Road
                         San Carlos, California 94070
                         Attention: Stephen L. Hurst, Esq.

                         With a copy to:

                         Cooley Godward LLP
                         3000 Sand Hill Road
                         Building #3, Suite 230


                                         17.

<PAGE>

                         Menlo Park, California  94025
                         Attention:  Marc P. Tanoury, Esq.

     All such notices and communications shall be deemed to have been duly
given: at the time delivered by hand, if personally delivered; five Business
Days after being deposited in the mail, postage prepaid, if mailed; when
answered back, if telexed; when receipt acknowledged, if telecopied; and on the
next Business Day, if timely delivered to an air courier guaranteeing overnight
delivery.

     (f)  SUCCESSORS AND ASSIGNS. This Agreement shall inure to the benefit of
and be binding upon the successors and assigns of each of the parties, including
without limitation and without the need for an express assignment, subsequent
Holders of Transfer Restricted Securities; provided, however, that (i) this
Agreement shall not inure to the benefit of or be binding upon a successor or
assign of a Holder unless and to the extent such successor or assign acquired
Transfer Restricted Securities from such Holder and (ii) nothing contained
herein shall be deemed to permit any assignment, transfer or other disposition
of Transfer Restricted Securities in violation of the terms of the Purchase
Agreement or the Indenture.  If any transferee of any Holder shall acquire
Transfer Restricted Securities, in any manner, whether by operation of law or
otherwise, such Transfer Restricted Securities shall be held subject to all of
the terms of this Agreement, and by taking and holding such Transfer Restricted
Securities such person shall be conclusively deemed to have agreed to be bound
by and to perform all of the terms and provisions of this Agreement.

     (g)  COUNTERPARTS. This Agreement may be executed in any number of
counterparts and by the parties hereto in separate counterparts, each of which
when so executed shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement.

     (h)  SECURITIES HELD BY THE ISSUER OR THEIR AFFILIATES.  Whenever the
consent or approval of Holders of a specified percentage of Transfer Restricted
Securities is required hereunder, Transfer Restricted Securities held by the
Issuer or its "affiliates" (as such term is defined in Rule 405 under the
Securities Act) shall not be counted in determining whether such consent or
approval was given by the Holders of such required percentage.

     (i)  HEADINGS. The headings in this Agreement are for convenience of
reference only and shall not limit or otherwise affect the meaning hereof.

     (j)  GOVERNING LAW.  This Agreement shall be governed by, and construed in
accordance with, the law of the State of New York, without regard to conflict of
laws principles thereof.

     (k)  SEVERABILITY. If  any one or more of the provisions contained herein,
or the application thereof in any circumstance, is held invalid, illegal or
unenforceable, the validity, legality and enforceability of any such provision
in every other respect and of the remaining provisions contained herein shall
not be affected or impaired thereby.


                                         18.

<PAGE>

     (l)  ENTIRE AGREEMENT.  This Agreement is intended by the parties as a
final expression of their agreement and intended to be a complete and exclusive
statement of the agreement and understanding of the parties hereto in respect of
the subject matter contained herein.  There are no restrictions, promises,
warranties or undertakings, other than those set forth or referred to herein
with respect to the registration rights granted by the Issuer with respect to
the Transfer Restricted Securities.  This Agreement supersedes all prior
agreements and understandings between the parties with respect to such subject
matter.


                                         19.

<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first written above.


                                        INHALE THERAPEUTIC SYSTEMS, INC.



                                        By______________________________
                                           Name:
                                           Title:

                                        MERRILL LYNCH, PIERCE, FENNER & SMITH
                                                  INCORPORATED
                                        DEUTSCHE BANK SECURITIES INC.
                                        LEHMAN BROTHERS INC.
                                        U.S. BANCORP PIPER JAFFRAY INC.

                                        By: Merrill Lynch, Pierce, Fenner &
                                                  Smith Incorporated


                                        By_____________________________
                                            Authorized Signatory


                                         20.

<PAGE>

                                                                       EXHIBIT A


                          INHALE THERAPEUTIC SYSTEMS, INC.

              FORM OF SELLING SECURITYHOLDER NOTICE AND QUESTIONNAIRE

     The undersigned beneficial holder of 5% Convertible Subordinated Notes due
2007 (the "Notes") of Inhale Therapeutic Systems, Inc. (the "Issuer"), or common
stock, par value $.001 per share (the "Shares" and together with the Notes, the
"Transfer Restricted Securities") of the Issuer understands that the Issuer has
filed, or intends to file, with the Securities and Exchange Commission (the
"Commission") a registration statement (the "Shelf Registration Statement"), for
the registration and resale under Rule 415 of the Securities Act of 1933, as
amended (the "Securities Act"), of the Transfer Restricted Securities in
accordance with the terms of the Registration Rights Agreement, dated as of
February 8, 2000 (the "Registration Rights Agreement") between the Issuer and
Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner & Smith Incorporated, Lehman
Brothers Inc., Deutsche Bank Securities Inc. and U.S. Bancorp Piper Jaffray Inc.
A copy of the Registration Rights Agreement is available from the Issuer upon
request at the address set forth below.  All capitalized terms not otherwise
defined herein have the meaning ascribed thereto in the Registration Rights
Agreement.

     Each beneficial owner of Transfer Restricted Securities is entitled to the
benefits of the Registration Rights Agreement.  In order to sell or otherwise
dispose of any Transfer Restricted Securities pursuant to the Shelf Registration
Statement, a beneficial owner of Transfer Restricted Securities generally will
be required to be named as a selling securityholder in the related Prospectus,
deliver a Prospectus to purchasers of Transfer Restricted Securities and be
bound by those provisions of the Registration Rights Agreement applicable to
such beneficial owner (including certain indemnification provisions, as
described below).  BENEFICIAL OWNERS THAT DO NOT COMPLETE THIS NOTICE AND
QUESTIONNAIRE WITHIN 20 BUSINESS DAYS OF RECEIPT HEREOF AND DELIVER IT TO THE
ISSUER AS PROVIDED BELOW WILL NOT BE NAMED AS SELLING SECURITYHOLDERS IN THE
PROSPECTUS AND THEREFORE WILL NOT BE PERMITTED TO SELL ANY TRANSFER RESTRICTED
SECURITIES PURSUANT TO THE SHELF REGISTRATION STATEMENT.

     Certain legal consequences arise from being named as a selling
securityholder in the Shelf Registration Statement and the related Prospectus.
Accordingly, holders and beneficial owners of Transfer Restricted Securities are
advised to consult their own securities law counsel regarding the consequences
of being named or not being named as a selling securityholder in the Shelf
Registration Statement and the related Prospectus.

                                       NOTICE

     The undersigned beneficial owner (the "Selling Securityholder") of Transfer
Restricted Securities hereby gives notice to the Issuer of its intention to sell
or otherwise dispose of Transfer Restricted Securities beneficially owned by it
and listed below in Item 3 (unless otherwise specified under Item 3) pursuant to
the Shelf Registration Statement.  The


                                          1.

<PAGE>

undersigned, by signing and returning this Notice and Questionnaire, understands
that it will be bound by the terms and conditions of this Notice and
Questionnaire and the Registration Rights Agreement.

     Pursuant to the Registration Rights Agreement, the undersigned has agreed
to indemnify and hold harmless the Issuer, the Issuer's directors, the Issuer's
officers who sign the Shelf Registration Statement and each person, if any, who
controls the Issuer within the meaning of either Section 15 of the Securities
Act or Section 20 of the Exchange Act, from and against certain losses arising
in connection with statements concerning the undersigned made in the Shelf
Registration Statement or the related Prospectus in reliance upon the
information provided in this Notice and Questionnaire.

     The undersigned hereby provides the following information to the Issuer and
represents and warrants that such information is accurate and complete:

                                   QUESTIONNAIRE

1.   (a)  Full legal name of Selling Securityholder:


     (b)  Full legal name of registered holder (if not the same as (a) above)
          through which Transfer Restricted Securities listed in (3) below are
          held:


     (c)  Full legal name of DTC participant (if applicable and if not the same
          as (b) above) through which Transfer Restricted Securities listed in
          (3) are held:


2.   Address for notices to Selling Securityholders:

     Telephone:

     Fax:

     Contact Person:

3.   Beneficial ownership of Transfer Restricted Securities:

     (a)  Type of Transfer Restricted Securities beneficially owned, and
          principal amount of Notes or number of shares of Common Stock, as the
          case may be, beneficially owned:



     (b)  CUSIP No(s). of such Transfer Restricted Securities beneficially
          owned:


                                          2.

<PAGE>

4.   Beneficial ownership of the Issuer's securities owned by the Selling
Securityholder:

     EXCEPT AS SET FORTH BELOW IN THIS ITEM (4), THE UNDERSIGNED IS NOT THE
     BENEFICIAL OR REGISTERED OWNER OF ANY SECURITIES OF THE ISSUER OTHER THAN
     THE TRANSFER RESTRICTED SECURITIES LISTED ABOVE IN ITEM (3) ("OTHER
     SECURITIES").

     (a)   Type and amount of Other Securities beneficially owned by the Selling
           Securityholder:


     (b)   CUSIP No(s). of such Other Securities beneficially owned:


5.   Relationship with the Issuer

     Except as set forth below, neither the undersigned nor any of its
     affiliates, officers, directors or principal equity holders (5% or more)
     has held any position or office or has had any other material relationship
     with the Issuer (or their predecessors or affiliates) during the past three
     years.

     State any exceptions here:



6.   Plan of Distribution

     Except as set forth below, the undersigned (including its donees or
     pledgees) intends to distribute the Transfer Restricted Securities listed
     above in Item (3) pursuant to the Shelf Registration Statement only as
     follows (if at all).  Such Transfer Restricted Securities may be sold from
     time to time directly by the undersigned or, alternatively, through
     underwriters, broker-dealers or agents.  If the Transfer Restricted
     Securities are sold through underwriters or broker-dealers, the Selling
     Securityholder will be responsible for underwriting discounts or
     commissions or agent's commissions.  Such Transfer Restricted Securities
     may be sold in one or more transactions at fixed prices, at prevailing
     market prices at the time of sale, at varying prices determined at the time
     of sale, or at negotiated prices.  Such sales may be effected in
     transactions (which may involve crosses or block transactions):


     (i)   on any national securities exchange or quotation service on which the
Transfer Restricted Securities may be listed or quoted at the time of sale;

     (ii)  in the over-the-counter market;

     (iii) in transactions otherwise than on such exchanges or services or in
     the over-the-counter market; or


                                          3.

<PAGE>

     (iv)  through the writing of options.

In connection with sales of the Transfer Restricted Securities or otherwise, the
undersigned may enter into hedging transactions with broker-dealers, which may
in turn engage in short sales of the Transfer Restricted Securities and deliver
Transfer Restricted Securities to close out such short positions, or loan or
pledge Transfer Restricted Securities to broker-dealers that in turn may sell
such securities.

State any exceptions here:



Note: In no event will such method(s) of distribution take the form of an
underwritten offering of the Transfer Restricted Securities without the prior
agreement of the Issuer.

     The undersigned acknowledges that it understands its obligation to comply
with the provisions of the Exchange Act and the rules and regulations
promulgated thereunder relating to stock manipulation, particularly Regulation M
thereunder (or any successor rules or regulations), in connection with any
offering of Transfer Restricted Securities pursuant to the Shelf Registration
Statement.  The undersigned agrees that neither it nor any person acting on its
behalf will engage in any transaction in violation of such provisions.

     The Selling Securityholder hereby acknowledges its obligations under the
Registration Rights Agreement to indemnify and hold harmless certain persons as
set forth therein.

     Pursuant to the Registration Rights Agreement, the Issuer has agreed under
certain circumstances to indemnify the Selling Securityholders against certain
liabilities.

     In accordance with the undersigned's obligation under the Registration
Rights Agreement to provide such information as may be required by law for
inclusion in the Shelf Registration Statement, the undersigned agrees to
promptly notify the Issuer of any inaccuracies or changes in the information
provided herein that may occur subsequent to the date hereof at any time while
the Shelf Registration Statement remains effective.  All notices hereunder and
pursuant to the Registration Rights Agreement shall be made in writing at the
address set forth below.

     By signing below, the undersigned consents to the disclosure of the
information contained herein in its answers to items (1) through (6) above and
the inclusion of such information in the Shelf Registration Statement and the
related Prospectus. The undersigned understands that such information will be
relied upon by the Issuer in connection with the preparation or amendment of the
Shelf Registration Statement and the related Prospectus.


                                          4.

<PAGE>

     IN WITNESS WHEREOF, the undersigned, by authority duly given, has caused
this Notice and Questionnaire to be executed and delivered either in person or
by its duly authorized agent.

Dated:

Beneficial Owner

By:
   ------------------------------
     Name:
     Title:



Please return the completed and executed Notice and Questionnaire to Inhale
Therapeutic Systems, Inc. at:

           Inhale Therapeutic Systems, Inc.
           150 Industrial Road
           San Carlos, California 94070
           Attention: Stephen L. Hurst, Esq.


                                          5.

<PAGE>

                                                                    Exhibit 4.13

================================================================================



                                    INDENTURE


                                     BETWEEN


                        INHALE THERAPEUTIC SYSTEMS, INC.,

                                    AS ISSUER


                                       AND


                     CHASE MANHATTAN BANK AND TRUST COMPANY,
                              NATIONAL ASSOCIATION

                                   AS TRUSTEE





                 _____% CONVERTIBLE SUBORDINATED NOTES DUE 2007


                          DATED AS OF FEBRUARY 8, 2000

================================================================================


<PAGE>



                             CROSS-REFERENCE TABLE*

<TABLE>
<CAPTION>

Trust Indenture                                                                                           Indenture
Act Section                                                                                                 Section
- -----------                                                                                                 -------

<S>      <C>                                                                                         <C>
310(a)(1)......................................................................................................5.11
         (a)(2)................................................................................................5.11
         (a)(3).................................................................................................n/a
         (a)(4).................................................................................................n/a
         (a)(5)................................................................................................5.11
         (b)..............................................................................................5.3; 5.11
         (c)....................................................................................................n/a

311(a)   5.12
         (b)...................................................................................................5.12
         (c)....................................................................................................n/a

312(a)   2.10
         (b) ..................................................................................................14.3
         (c)...................................................................................................14.3

313(a)   5.7
         (b)(1).................................................................................................n/a
         (b)(2).................................................................................................5.7
         (c)..............................................................................................5.7; 14.2
         (d)....................................................................................................5.7

314(a)(1), (2), (3).......................................................................................9.6; 14.6
         (a)(4)......................................................................................9.6; 9.7; 14.6
         (b)....................................................................................................n/a
         (c)(1)................................................................................................14.5
         (c)(2)................................................................................................14.5
         (c)(3).................................................................................................n/a
         (d)....................................................................................................n/a
         (e)...................................................................................................14.6
         (f)....................................................................................................n/a

315(a)   ....................................................................................................5.1(a)
         (b)..............................................................................................5.6; 14.2
         (c).................................................................................................5.1(b)
         (d).................................................................................................5.1(c)
         (e)...................................................................................................4.14

316(a)(last sentence)..........................................................................................2.13
         (a)(1)(A)..............................................................................................4.5
         (a)(1)(B)..............................................................................................4.4



                                       i.
<PAGE>


         (a)(2).................................................................................................n/a
         (b)....................................................................................................4.7
         (c)....................................................................................................7.4

317(a)(1).......................................................................................................4.8
         (a)(2).................................................................................................4.9
         (b)....................................................................................................2.5

318(a)   14.1
         (b)....................................................................................................n/a
         (c)...................................................................................................14.1
</TABLE>

- --------------------------------
"n/a" means not applicable.

*This Cross-Reference Table shall not, for any purpose, be deemed to be a part
of the Indenture.



                                       ii.
<PAGE>



                                TABLE OF CONTENTS

                                                                            PAGE

                                Table of Contents

<TABLE>
<CAPTION>

                                                                                                               PAGE
                                                                                                               ----
<S>               <C>                                                                                            <C>
ARTICLE 1         DEFINITIONS AND INCORPORATION BY REFERENCE

Section 1.1.      Definitions.....................................................................................2
Section 1.2.      Incorporation by Reference of Trust Indenture Act..............................................13
Section 1.3.      Rules of Construction..........................................................................14

ARTICLE 2         THE SECURITIES

Section 2.1.      Title and Terms................................................................................15
Section 2.2.      Form of Securities.............................................................................16
Section 2.3.      Legends........................................................................................17
Section 2.4.      Execution, Authentication, Delivery and Dating.................................................22
Section 2.5.      Registrar and Paying Agent.....................................................................22
Section 2.6.      Paying Agent to Hold Assets in Trust...........................................................23
Section 2.7.      General Provisions Relating to Transfer and Exchange...........................................23
Section 2.8.      Book-Entry Provisions for the Global Securities................................................24
Section 2.9.      Special Transfer Provisions....................................................................25
Section 2.10.     Holder Lists...................................................................................27
Section 2.11.     Persons Deemed Owners..........................................................................28
Section 2.12.     Mutilated, Destroyed, Lost or Stolen Securities................................................28
Section 2.13.     Treasury Securities............................................................................29
Section 2.14.     Temporary Securities...........................................................................29
Section 2.15.     Cancellation...................................................................................29
Section 2.16.     CUSIP Numbers..................................................................................30
Section 2.17.     Defaulted Interest.............................................................................30

ARTICLE 3         SATISFACTION AND DISCHARGE

Section 3.1.      Satisfaction and Discharge of Indenture........................................................31
Section 3.2.      Deposited Monies to be Held in Trust...........................................................32
Section 3.3.      Return of Unclaimed Monies.....................................................................32

ARTICLE 4         DEFAULTS AND REMEDIES

Section 4.1.      Events of Default..............................................................................33
Section 4.2.      Acceleration of Maturity; Rescission and Annulment.............................................34
Section 4.3.      Other Remedies.................................................................................35
Section 4.4.      Waiver of Past Defaults........................................................................35
Section 4.5.      Control by Majority............................................................................35
Section 4.6.      Limitation on Suit.............................................................................36
Section 4.7.      Unconditional Rights of Holders to Receive Payment and to Convert..............................36
</TABLE>



                                       iii.
<PAGE>


                               TABLE OF CONTENTS
                                  (CONTINUED)

<TABLE>
<CAPTION>

                                                                                                                PAGE
<S>               <C>                                                                                            <C>
Section 4.8.      Collection of Indebtedness and Suits for Enforcement by the Trustee............................37
Section 4.9.      Trustee May File Proofs of Claim...............................................................37
Section 4.10.     Restoration of Rights and Remedies.............................................................38
Section 4.11.     Rights and Remedies Cumulative.................................................................38
Section 4.12.     Delay or Omission Not Waiver...................................................................38
Section 4.13.     Application of Money Collected.................................................................39
Section 4.14.     Undertaking for Costs..........................................................................39
Section 4.15.     Waiver of Stay or Extension Laws...............................................................39

ARTICLE 5         THE TRUSTEE

Section 5.1.      Certain Duties and Responsibilities............................................................41
Section 5.2.      Certain Rights of Trustee......................................................................42
Section 5.3.      Individual Rights of Trustee...................................................................43
Section 5.4.      Money Held in Trust............................................................................43
Section 5.5.      Trustee's Disclaimer...........................................................................43
Section 5.6.      Notice of Defaults.............................................................................44
Section 5.7.      Reports by Trustee to Holders..................................................................44
Section 5.8.      Compensation and Indemnification...............................................................44
Section 5.9.      Replacement of Trustee.........................................................................45
Section 5.10.     Successor Trustee by Merger, Etc...............................................................46
Section 5.11.     Corporate Trustee Required; Eligibility........................................................46
Section 5.12.     Collection of Claims Against the Company.......................................................46

ARTICLE 6         CONSOLIDATION, MERGER, CONVEYANCE, TRANSFER OR LEASE

Section 6.1.      Company May Consolidate, Etc...................................................................47
Section 6.2.      Successor Corporation Substituted..............................................................47

ARTICLE 7         AMENDMENTS, SUPPLEMENTS AND WAIVERS

Section 7.1.      Without Consent of Holders of Securities.......................................................49
Section 7.2.      With Consent of Holders of Securities..........................................................50
Section 7.3.      Compliance with Trust Indenture Act............................................................51
Section 7.4.      Revocation of Consents and Effect of Consents or Votes.........................................51
Section 7.5.      Notation on or Exchange of Securities..........................................................51
Section 7.6.      Trustee to Sign Amendment, Etc.................................................................52

ARTICLE 8         MEETING OF HOLDERS OF SECURITIES

Section 8.1.      Purposes for Which Meetings May Be Called......................................................53
Section 8.2.      Call Notice and Place of Meetings..............................................................53
Section 8.3.      Persons Entitled to Vote at Meetings...........................................................53
Section 8.4.      Quorum; Action.................................................................................53
</TABLE>



                                       IV.
<PAGE>


                               TABLE OF CONTENTS
                                  (CONTINUED)

<TABLE>
<CAPTION>

                                                                                                                PAGE
<S>               <C>                                                                                            <C>


Section 8.5.      Determination of Voting Rights; Conduct and Adjournment of Meetings............................54
Section 8.6.      Counting Votes and Recording Action of Meetings................................................55

ARTICLE 9         COVENANTS

Section 9.1.      Payment of Principal, Premium and Interest.....................................................56
Section 9.2.      Maintenance of Offices or Agencies.............................................................56
Section 9.3.      Corporate Existence............................................................................57
Section 9.4.      Maintenance of Properties......................................................................57
Section 9.5.      Payment of Taxes and Other Claims..............................................................57
Section 9.6.      Reports........................................................................................57
Section 9.7.      Compliance Certificate.........................................................................58
Section 9.8.      Resale of Certain Securities...................................................................58

ARTICLE 10        REDEMPTION OF SECURITIES

Section 10.1.     Provisional Redemption.........................................................................59
Section 10.2.     Optional Redemption............................................................................59
Section 10.3.     Notice to Trustee..............................................................................60
Section 10.4.     Selection of Securities to Be Redeemed.........................................................60
Section 10.5.     Notice of Redemption...........................................................................60
Section 10.6.     Effect of Notice of Redemption.................................................................61
Section 10.7.     Deposit of Redemption Price....................................................................61
Section 10.8.     Securities Redeemed in Part....................................................................62

ARTICLE 11        REPURCHASE AT THE OPTION OF A HOLDER UPON A CHANGE OF CONTROL

Section 11.1.     Repurchase Right...............................................................................63
Section 11.2.     Conditions to the Company's Election to Pay the Repurchase Price in Common Stock...............63
Section 11.3.     Notices; Method of Exercising Repurchase Right, Etc............................................64

ARTICLE 12        CONVERSION OF SECURITIES

Section 12.1.     Conversion Right and Conversion Price..........................................................68
Section 12.2.     Exercise of Conversion Right...................................................................68
Section 12.3.     Fractions of Shares............................................................................69
Section 12.4.     Adjustment of Conversion Price.................................................................69
Section 12.5.     Notice of Adjustments of Conversion Price......................................................78
Section 12.6.     Notice Prior to Certain Actions................................................................78
Section 12.7.     Company to Reserve Common Stock................................................................79
Section 12.8.     Taxes on Conversions...........................................................................79
Section 12.9.     Covenant as to Common Stock....................................................................80
</TABLE>



                                       V.
<PAGE>


                               TABLE OF CONTENTS
                                  (CONTINUED)

<TABLE>
<CAPTION>

                                                                                                                PAGE
<S>               <C>                                                                                            <C>
Section 12.10.    Cancellation of Converted Securities...........................................................80
Section 12.11.    Effect of Reclassification, Consolidation, Merger or Sale......................................80
Section 12.12.    Responsibility of Trustee for Conversion Provisions............................................81

ARTICLE 13        SUBORDINATION

Section 13.1.     Securities Subordinated to Senior Debt.........................................................83
Section 13.2.     Subrogation....................................................................................85
Section 13.3.     Obligation of the Company is Absolute and Unconditional........................................85
Section 13.4.     Maturity of or Default on Senior Debt..........................................................85
Section 13.5.     Payments on Securities Permitted...............................................................86
Section 13.6.     Effectuation of Subordination by Trustee.......................................................86
Section 13.7.     Knowledge of Trustee...........................................................................86
Section 13.8.     Trustee's Relation to Senior Debt..............................................................87
Section 13.9.     Rights of Holders of Senior Debt Not Impaired..................................................87
Section 13.10.    Modification of Terms of Senior Debt...........................................................87
Section 13.11.    Certain Conversions Not Deemed Payment.........................................................87

ARTICLE 14        OTHER PROVISIONS OF GENERAL APPLICATION

Section 14.1.     Trust Indenture Act Controls...................................................................89
Section 14.2.     Notices........................................................................................89
Section 14.3.     Communication by Holders with Other Holders....................................................90
Section 14.4.     Acts of Holders of Securities..................................................................90
Section 14.5.     Certificate and Opinion as to Conditions Precedent.............................................91
Section 14.6.     Statements Required in Certificate or Opinion..................................................91
Section 14.7.     Effect of Headings and Table of Contents.......................................................92
Section 14.8.     Successors and Assigns.........................................................................92
Section 14.9.     Separability Clause............................................................................92
Section 14.10.    Benefits of Indenture..........................................................................92
Section 14.11.    Governing Law..................................................................................92
Section 14.12.    Counterparts...................................................................................92
Section 14.13.    Legal Holidays.................................................................................92
Section 14.14.    Recourse Against Others........................................................................93
</TABLE>



                                       VI.
<PAGE>


                               TABLE OF CONTENTS
                                  (CONTINUED)

<TABLE>
<CAPTION>

                                                                                             PAGE
<S>               <C>                                                                         <C>
EXHIBITS

    EXHIBIT A:    Form of Security                                                            A-1
</TABLE>



                                      vii.
<PAGE>


An extra section break has been inserted above this paragraph. Do not delete
this section break if you plan to add text after the Table of
Contents/Authorities. Deleting this break will cause Table of
Contents/Authorities headers and footers to appear on any pages following the
Table of Contents/Authorities.



                                       viii.
<PAGE>


         INDENTURE, dated as of February 8, 2000, between INHALE THERAPEUTIC
SYSTEMS, INC., a corporation duly organized and existing under the laws of the
State of Delaware, having its principal office at 150 Industrial Road, San
Carlos, California 94070 (the "Company"), and CHASE MANHATTAN BANK AND TRUST
COMPANY, NATIONAL ASSOCIATION, a national banking association, as Trustee (the
"Trustee"), having its principal corporate trust office at 101 California
Street, Suite 2725, San Francisco, California 94111.

                             RECITALS OF THE COMPANY

         The Company has duly authorized the creation of an issue of its 5%
Convertible Subordinated Notes due 2007 (herein called the "Securities") of
substantially the tenor and amount hereinafter set forth, and to provide
therefor the Company has duly authorized the execution and delivery of this
Indenture.

         All things necessary to make the Securities, when the Securities are
executed by the Company and authenticated and delivered hereunder and duly
issued by the Company, the valid obligations of the Company, and to make this
Indenture a valid agreement of the Company, in accordance with their and its
terms, have been done.

                  NOW, THEREFORE, THIS INDENTURE WITNESSETH:

         For and in consideration of the premises and the purchase of the
Securities by the Holders thereof, it is mutually covenanted and agreed, for the
equal and proportionate benefit of all Holders of the Securities, as follows:


<PAGE>


                                    ARTICLE 1

                          DEFINITIONS AND INCORPORATION
                                  BY REFERENCE


         SECTION 1.1       DEFINITIONS.

         For all purposes of this Indenture and the Securities, the following
terms are defined as follows:

                 "Act", when used with respect to any Holder of a Security, has
         the meaning specified in Section 14.4(a) hereof.

                 "Adjusted Interest Rate" means, with respect to any Reset
         Transaction, the rate per annum that is the arithmetic average of the
         rates quoted by two Reference Dealers selected by the Company or its
         successor as the rate at which interest on the Securities should accrue
         so that the fair market value, expressed in dollars, of a Security
         immediately after the later of:

                          (1) the public announcement of such Reset Transaction;
         or

                          (2) the public announcement of a change in dividend
         policy in connection with such Reset Transaction,

will equal the average Trading Price of a Security for the 20 Trading Days
preceding the date of public announcement of such Reset Transaction; provided
that the Adjusted Interest Rate shall not be less than 5% per annum.

                 "Affiliate" of any specified Person means any other Person
         directly or indirectly controlling or controlled by or under direct or
         indirect common control with such specified Person. For the purposes of
         this definition, "control", when used with respect to any specified
         Person, means the power to direct the management and policies of such
         Person, directly or indirectly, whether through the ownership of voting
         securities, by contract or otherwise; and the terms "controlling" and
         "controlled" have meanings correlative to the foregoing.

                 "Bankruptcy Law" means Title 11 of the U.S. Code or any
         similar federal or state law for the relief of debtors.

                 "Board of Directors" means either the board of directors of the
         Company or any committee of that board empowered to act for it with
         respect to this Indenture.

                 "Board Resolution" means a resolution duly adopted by the Board
         of Directors, a copy of which, certified by the Secretary or an
         Assistant Secretary of the Company to be in full force and effect on
         the date of such certification, shall have been delivered to the
         Trustee.



                                       2
<PAGE>


                  "Business Day", when used with respect to any Place of Payment
         or Place of Conversion, means each Monday, Tuesday, Wednesday, Thursday
         and Friday which is not a day on which banking institutions in that
         Place of Payment or Place of Conversion, as the case may be, are
         authorized or obligated by law to close.

                  "Change of Control" means the occurrence of any of the
         following after the original issuance of the Securities:

                           (1) the acquisition by any person, including any
         syndicate or group deemed to be a "person" under Section 13(d)(3) of
         the Exchange Act, of beneficial ownership, directly or indirectly,
         through a purchase, merger or other acquisition transaction or series
         of transactions, of shares of capital stock of the Company entitling
         such person to exercise 50% or more of the total voting power of all
         shares of capital stock of the Company entitled to vote generally in
         elections of directors, other than any such acquisition by the Company,
         any subsidiary of the Company or any employee benefit plan of the
         Company; or

                           (2) any consolidation or merger of the Company with
         or into any other person, any merger of another person into the
         Company, or any conveyance, transfer, sale, lease or other disposition
         of all or substantially all of the properties and assets of the Company
         to another person, other than (a) any such transaction (x) that does
         not result in any reclassification, conversion, exchange or
         cancellation of outstanding shares of capital stock of the Company and
         (y) pursuant to which holders of capital stock of the Company
         immediately prior to such transaction have the entitlement to exercise,
         directly or indirectly, 50% or more of the total voting power of all
         shares of capital stock of the Company entitled to vote generally in
         the election of directors of the continuing or surviving person
         immediately after such transaction and (b) any merger which is effected
         solely to change the jurisdiction of incorporation of the Company and
         results in a reclassification, conversion or exchange of outstanding
         shares of Common Stock solely into shares of common stock of the
         surviving entity;

provided, however, that a Change of Control shall not be deemed to have occurred
if the closing sales price per share of the Common Stock for any five Trading
Days within the period of 10 consecutive Trading Days ending immediately after
the later of the Change of Control or the public announcement of the Change of
Control, in the case of a Change of Control under clause (1) above, or the
period of 10 consecutive Trading Days ending immediately before the Change of
Control, in the case of a Change of Control under clause (2) above, shall equal
or exceed 110% of the Conversion Price of the Securities in effect on each such
Trading Day. Beneficial ownership shall be determined in accordance with Rule
13d-3 promulgated by the SEC under the Exchange Act. The term "person" shall
include any syndicate or group which would be deemed to be a "person" under
Section 13(d)(3) of the Exchange Act.

                 "Chief Executive Officer" means any co-chief executive officer
         of the Company.

                 "Closing Date" means February 8, 2000 or such later date on
         which the Securities may be delivered pursuant to the Purchase
         Agreement.



                                       3
<PAGE>


                  "Closing Price" of any security on any date of determination
         means:

                           (1) the closing sale price (or, if no closing sale
         price is reported, the last reported sale price) of such security on
         the New York Stock Exchange on such date;

                           (2) if such security is not listed for trading on the
         New York Stock Exchange on any such date, the closing sale price as
         reported in the composite transactions for the principal U.S.
         securities exchange on which such security is so listed;

                           (3) if such security is not so listed on a U.S.
         national or regional securities exchange, the closing sale price as
         reported by the NASDAQ National Market;

                           (4) if such security is not so reported, the last
         quoted bid price for such security in the over-the-counter market as
         reported by the National Quotation Bureau or similar organization; or

                           (5) if such bid price is not available, the average
         of the mid-point of the last bid and ask prices of such security on
         such date from at least three nationally recognized independent
         investment banking firms retained for this purpose by the Company.

                 "Common Stock" means any stock of any class of the Company
         which has no preference in respect of dividends or of amounts payable
         in the event of any voluntary or involuntary liquidation, dissolution
         or winding up of the Company and which is not subject to redemption by
         the Company. However, subject to the provisions of Section 12.11
         hereof, shares issuable on conversion of Securities shall include only
         shares of the class designated as Common Stock, par value $0.0001 per
         share, of the Company at the date of this Indenture or shares of any
         class or classes resulting from any reclassification or
         reclassifications thereof and which have no preference in respect of
         dividends or of amounts payable in the event of any voluntary or
         involuntary liquidation, dissolution or winding up of the Company and
         which are not subject to redemption by the Company, provided that if at
         any time there shall be more than one such resulting class, the shares
         of each such class then so issuable shall be substantially in the
         proportion which the total number of shares of such class resulting
         from all such reclassifications bears to the total number of shares of
         all such classes resulting from all such reclassifications.

                 "Company" means the corporation named as the "Company" in the
         first paragraph of this instrument until a successor corporation shall
         have become such pursuant to the applicable provisions of this
         Indenture, and thereafter "Company" shall mean such successor
         corporation.

                 "Company Notice" has the meaning specified in Section 11.3
         hereof.

                 "Company Order" means a written order signed in the name of the
         Company by both (1) the Chairman of the Board, the Chief Executive
         Officer, the President or a Vice President and (2) so long as not the
         same as the officer signing pursuant to clause (1), the



                                       4
<PAGE>


         Chief Financial Officer, the Treasurer or the Secretary of the Company,
         and delivered to the Trustee.

                 "Conversion Agent" means any Person authorized by the Company
         to convert Securities in accordance with Article 12 hereof.

                 "Conversion Price" has the meaning specified in Section 12.1
         hereof.

                 "Corporate Trust Office" means for purposes of presentation or
         surrender of Securities for payment, registration, transfer, exchange
         or conversion or for service of notices or demands upon the Company,
         the office of the Trustee located in The City of New York at which at
         any particular time its corporate trust business shall be administered
         (which at the date of this Indenture is located at 55 Water Street,
         Room 234, North Building, New York, New York 10041), and for all other
         purposes, the office of the Trustee located in the City of San
         Francisco (which at the date of this Indenture is located at 101
         California Street, Suite 2725, San Francisco, CA 94111).

                 "Corporation" means corporations, associations, limited
         liability companies, companies and business trusts.

                 "Current Market Price" has the meaning set forth in Section
         12.4(g).

                 "Custodian" means any receiver, trustee, assignee, liquidator,
         sequestrator or similar official under any Bankruptcy Law.

                 "Default" means an event which is, or after notice or lapse of
         time or both would be, an Event of Default.

                 "Default Exception" has the meaning specified in Section
         4.1(d) hereof.

                 "Defaulted Interest" has the meaning specified in Section 2.17
         hereof.

                 "Depositary" means The Depository Trust Company, its nominees
and their respective successors.

                 "Designated Senior Debt" means Senior Debt of the Company
         which, at the date of determination, has an aggregate amount
         outstanding of, or under which, at the date of determination, the
         holders thereof are committed to lend up to, at least $25 million and
         is specifically designated in the instrument, agreement or other
         document evidencing or governing that Senior Debt as "Designated Senior
         Debt" for purposes of this Indenture (provided that such instrument,
         agreement or other document may place limitations and conditions on the
         right of such Senior Debt to exercise the rights of Designated Senior
         Debt).

                 "Dividend Yield" on any security for any period means the
         dividends paid or proposed to be paid pursuant to an announced dividend
         policy on such security for such period divided by, if with respect to
         dividends paid on such security, the average Closing



                                       5
<PAGE>


         Price of such security during such period and, if with respect to
         dividends proposed to be paid on such security, the Closing Price of
         such security on the effective date of the related Reset Transaction.

                 "Dollar," "U.S. Dollar" or "U.S. $" means a dollar or other
         equivalent unit in such coin or currency of the United States as at the
         time shall be legal tender for the payment of public and private debts.

                 "DTC Participants" has the meaning specified in Section 2.8
         hereof.

                 "Event of Default" has the meaning specified in Section 4.1
         hereof.

                 "Exchange Act" means the Securities Exchange Act of 1934, as
         amended.

                 "Expiration Time" has the meaning specified in Section 12.4(f)
         hereof.

                 "Fair market value" has the meaning set forth in Section
         12.4(g) hereof.

                 "Global Security" has the meaning specified in Section 2.2
         hereof.

                 "Guarantee" means any obligation, contingent or otherwise, of
         any Person, directly or indirectly guaranteeing any Indebtedness of any
         other Person and any obligation, direct or indirect, contingent or
         otherwise, of such Person:

                           (1) to purchase or pay (or advance or supply funds
         for the purchase or payment of) such Indebtedness of such other Person
         (whether arising by virtue of partnership arrangements, or by agreement
         to keep-well, to purchase assets, goods, securities or services, to
         take-or-pay, or maintain financial statement conditions or otherwise);
         or

                           (2) entered into for purposes of assuring in any
         other manner the obligee of such Indebtedness of the payment thereof or
         to protect such obligee against loss in respect thereof (in whole or in
         part);

provided, however, that the term "guarantee" will not include endorsements for
collection or deposit in the ordinary course of business. The term "guarantee"
used as a verb has a corresponding meaning.

                 "Holder", when used with respect to any Security, means the
         Person in whose name the Security is registered in the Register.

                 "Indebtedness", when used with respect to any Person, and
         without duplication means:

                           (1) all indebtedness, obligations and other
         liabilities (contingent or otherwise) of such Person for borrowed money
         (including obligations of the Company in respect of overdrafts, foreign
         exchange contracts, currency exchange agreements, Interest



                                       6
<PAGE>


         Rate Protection Agreements, and any loans or advances from banks,
         whether or not evidenced by notes or similar instruments) or evidenced
         by bonds, debentures, notes or other instruments for the payment of
         money, or incurred in connection with the acquisition of any property,
         services or assets (whether or not the recourse of the lender is to the
         whole of the assets of such Person or to only a portion thereof), other
         than any account payable or other accrued current liability or
         obligation to trade creditors incurred in the ordinary course of
         business in connection with the obtaining of materials or services;

                           (2) all reimbursement obligations and other
         liabilities (contingent or otherwise) of such Person with respect to
         letters of credit, bank guarantees, bankers' acceptances, surety bonds,
         performance bonds or other guaranty of contractual performance;

                           (3) all obligations and liabilities (contingent or
         otherwise) in respect of (a) leases of such Person required, in
         conformity with generally accepted accounting principles, to be
         accounted for as capitalized lease obligations on the balance sheet of
         such Person and (b) any lease or related documents (including a
         purchase agreement) in connection with the lease of real property which
         provides that such Person is contractually obligated to purchase or
         cause a third party to purchase the leased property and thereby
         guarantee a minimum residual value of the leased property to the
         landlord and the obligations of such Person under such lease or related
         document to purchase or to cause a third party to purchase the leased
         property;

                           (4) all obligations of such Person (contingent or
         otherwise) with respect to an interest rate or other swap, cap or
         collar agreement or other similar instrument or agreement or foreign
         currency hedge, exchange, purchase or similar instrument or agreement;

                           (5) all direct or indirect guaranties or similar
         agreements by such Person in respect of, and obligations or liabilities
         (contingent or otherwise) of such Person to purchase or otherwise
         acquire or otherwise assure a creditor against loss in respect of,
         indebtedness, obligations or liabilities of another Person of the kind
         described in clauses (1) through (4);

                           (6) any indebtedness or other obligations described
         in clauses (1) through (4) secured by any mortgage, pledge, lien or
         other encumbrance existing on property which is owned or held by such
         Person, regardless of whether the indebtedness or other obligation
         secured thereby shall have been assumed by such Person; and

                           (7) any and all deferrals, renewals, extensions and
         refundings of, or amendments, modifications or supplements to, any
         indebtedness, obligation or liability of the kind described in clauses
         (1) through (6).



                                       7
<PAGE>


                 "Indenture" means this instrument as originally executed or as
         it may from time to time be supplemented or amended by one or more
         indentures supplemental hereto entered into pursuant to the applicable
         provisions hereof.

                 "Initial Purchasers" mean Merrill Lynch, Pierce, Fenner &
         Smith Incorporated, Deutsche Bank Securities Inc., Lehman Brothers Inc.
         and U.S. Bancorp Piper Jaffray Inc.

                 "Interest Payment Date" means each February 8 and August 8.

                 "Interest Rate" means, (a) if a Reset Transaction has not
         occurred, 5% per annum, or (b) following the occurrence of a Reset
         Transaction, the Adjusted Interest Rate related to such Reset
         Transaction to, but not including the effective date of any succeeding
         Reset Transaction.

                 "Interest Rate Protection Agreement" means, with respect to any
         Person, any interest rate swap agreement, interest rate cap or collar
         agreement or other financial agreement or arrangement designed to
         protect such person against fluctuations in interest rates, as in
         effect from time to time.

                 "Internal Revenue Code" means the Internal Revenue Code of
         1986, as amended.

                 "Liquidated Damages" means all liquidated damages, if any,
         payable pursuant to Section 3 of the Registration Rights Agreement.

                 "Maturity" means the date on which the principal of such
         Security becomes due and payable as therein or herein provided, whether
         at the Stated Maturity or by acceleration, conversion, call for
         redemption, exercise of a Repurchase Right or otherwise.

                 "Nasdaq National Market" means the National Association of
         Securities Dealers Automated Quotation National Market or any successor
         national securities exchange or automated over-the-counter trading
         market in the United States.

                 "Non-Electing Share" has the meaning specified in Section
         12.11 hereof.

                 "Officer" of the Company means the Chairman of the Board, the
         Chief Executive Officer, the President, the Chief Financial Officer,
         the Treasurer, any Vice President or the Secretary of the Company.

                 "Officers' Certificate" means a certificate signed by both (1)
         the Chairman of the Board, the Chief Executive Officer, the President
         or a Vice President and (2) so long as not the same as the officer
         signing pursuant to clause (1), the Chief Financial Officer or the
         Secretary of the Company, and delivered to the Trustee.

                 "Opinion of Counsel" means a written opinion of counsel, who
         may be counsel to the Company (and may include directors or employees
         of the Company) and which opinion is acceptable to the Trustee which
         acceptance shall not be unreasonably withheld.



                                       8
<PAGE>


                 "Outstanding", when used with respect to Securities, means, as
         of the date of determination, all Securities theretofore authenticated
         and delivered under this Indenture, except Securities:

                           (1) previously canceled by the Trustee or delivered
         to the Trustee for cancellation;

                           (2) for the payment or redemption of which money in
         the necessary amount has been previously deposited with the Trustee or
         any Paying Agent (other than the Company) in trust or set aside and
         segregated in trust by the Company (if the Company shall act as its own
         Paying Agent) for the Holders of such Securities, provided that if such
         Securities are to be redeemed, notice of such redemption has been duly
         given pursuant to this Indenture; and

                           (3) which have been paid, in exchange for or in lieu
         of which other Securities have been authenticated and delivered
         pursuant to this Indenture, other than any such Securities in respect
         of which there shall have been presented to the Trustee proof
         satisfactory to it that such Securities are held by a bona fide
         purchaser in whose hands such Securities are valid obligations of the
         Company.

                 "Paying Agent" has the meaning specified in Section 2.5 hereof.

                 "Payment Blockage Notice" has the meaning specified in Section
         13.1(d) hereof.

                 "Person" means any individual, corporation, limited liability
         company, partnership, joint venture, association, joint-stock company,
         trust, estate, unincorporated organization or government or any agency
         or political subdivision thereof.

                 "Physical Securities" has the meaning specified in Section 2.2
         hereof.

                 "Place of Conversion" means any city in which any Conversion
         Agent is located.

                 "Place of Payment" means any city in which any Paying Agent is
         located.

                 "Predecessor Security" of any particular Security means every
         previous Security evidencing all or a portion of the same debt as that
         evidenced by such particular Security; and, for the purposes of this
         definition, any Security authenticated and delivered under Section 2.12
         hereof in exchange for or in lieu of a mutilated, destroyed, lost or
         stolen Security shall be deemed to evidence the same debt as the
         mutilated, destroyed, lost or stolen Security.

                 "Purchase Agreement" means the Purchase Agreement, dated
         February 2, 2000, between the Company and the Initial Purchasers.

                 "QIB" means a "qualified institutional buyer" as defined in
         Rule 144A.



                                       9
<PAGE>


                 "Quoted Price" of the Common Stock means the last reported sale
         price of the Common Stock on the Nasdaq National Market, or, if the
         Common Stock is listed on a national securities exchange, then on such
         exchange, or if the Common Stock is not quoted on Nasdaq National
         Market or listed on an exchange, the average of the last bid and asked
         price on the National Association of Securities Dealers Automated
         Quotation System.

                 "Record Date" means either a Regular Record Date or a Special
         Record Date, as the case may be, provided that, for purposes of Section
         12.4 hereof, Record Date has the meaning specified in 12.4(g) hereof.

                 "Redemption Date", when used with respect to any Security to be
         redeemed, means the Optional Redemption Date in the event of an
         Optional Redemption or the Provisional Redemption Date, in the event of
         a Provisional Redemption, as the case may be.

                 "Redemption Price", when the Optional Redemption Price, in the
         event of an Optional Redemption, or the Provisional Redemption Price,
         in the event of a Provisional Redemption, as the case may be.

                 "Reference Dealer" means a dealer engaged in the trading of
         convertible securities.

                 "Reference Period" has the meaning set forth in Section
         12.4(d) hereof.

                 "Register" has the meaning specified in Section 2.5 hereof.

                 "Registrar" has the meaning specified in Section 2.5 hereof.

                 "Registration Rights Agreement" means the Registration Rights
         Agreement dated as of February 8, 2000, between the Company and the
         Initial Purchasers.

                 "Regular Record Date" for the interest on the Securities
         (including Liquidated Damages, if any) payable means the January 24
         (whether or not a Business Day) next preceding a February 8 Interest
         Payment Date and the July 24 (whether or not a Business Day) next
         preceding an August 8 Interest Payment Date.

                 "Repurchase Date" has the meaning specified in Section 11.1
         hereof.

                 "Repurchase Price" has the meaning specified in Section 11.1
         hereof.

                 "Repurchase Right" has the meaning specified in Section 11.1
         hereof.

                 "Reset Transaction" means a merger, consolidation or statutory
         share exchange to which the entity that is the issuer of the shares of
         common stock into which the Securities are then convertible into is a
         party, a sale of all or substantially all the assets of that entity, a
         recapitalization of those shares of common stock or a distribution
         described in



                                       10
<PAGE>


         Section 12.4(d) hereof, after the effective date of which transaction
         or distribution the Securities would be convertible into:

                           (1) shares of an entity the common stock of which had
         a Dividend Yield for the four fiscal quarters of such entity
         immediately preceding the public announcement of such transaction or
         distribution that was more than 2.5% higher then the Dividend Yield on
         the Common Stock (or other common stock then issuable upon conversion
         of the Securities) for the four fiscal quarters preceding the public
         announcement of such transaction or distribution, or

                           (2) shares of an entity that announces a dividend
         policy prior to the effective date of such transaction or distribution
         which policy, if implemented, would result in a Dividend Yield on such
         entity's common stock for the next four fiscal quarters that would
         result in such a 2.5% basis point increase.

                 "Responsible Officer", when used with respect to the Trustee,
         means any officer of the Trustee, including any vice president,
         assistant vice president, secretary, assistant secretary, the
         treasurer, any assistant treasurer, the managing director or any other
         officer of the Trustee customarily performing functions similar to
         those performed by any of the above designated officers and also means,
         with respect to a particular corporate trust matter, any other officer
         to whom such matter is referred because of such officer's knowledge of
         and familiarity with the particular subject.

                 "Restricted Securities" means the Securities defined as such
         in Section 2.3 hereof.

                 "Restricted Securities Legend" has the meaning set forth in
         Section 2.3(a) hereof.

                 "Rule 144" means Rule 144 under the Securities Act (including
         any successor rule thereof), as the same may be amended from time to
         time.

                 "Rule 144A" means Rule 144A as promulgated under the Securities
         Act (including any successor rule thereof), as the same may be amended
         from time to time.

                 "SEC" means the Securities and Exchange Commission.

                 "Securities" has the meaning ascribed to it in the first
         paragraph under the caption "Recitals of the Company".

                 "Securities Act" means the  Securities Act of 1933, as amended.

                 "Senior Debt" means the principal of, premium, if any, interest
         (including all interest accruing subsequent to the commencement of any
         bankruptcy or similar proceeding, whether or not a claim for
         post-petition interest is allowable as a claim in any such proceeding)
         and rent payable on or termination payment with respect to or in
         connection with, and all fees, costs, expenses and other amounts
         accrued or due on or in connection with, Indebtedness of the Company,
         whether outstanding on the date of this



                                       11
<PAGE>


         Indenture or thereafter created, incurred, assumed, guaranteed or in
         effect guaranteed by the Company (including all deferrals, renewals,
         extensions or refundings of, or amendments, modifications or
         supplements to, the foregoing), unless in the case of any particular
         Indebtedness the instrument creating or evidencing the same or the
         assumption or guarantee thereof expressly provides that such
         Indebtedness shall not be senior in right of payment to the Securities
         or expressly provides that such Indebtedness is PARI PASSU or junior to
         the Securities. The Securities shall not be senior in right of payment
         to the outstanding 6 3/4 % Convertible Subordinated Debentures due 2006
         (the "2006 Debentures") and shall rank PARI PASSU with the 2006
         Debentures. The 2006 Debentures shall not be Senior Debt, as that term
         is defined herein. Notwithstanding the foregoing, the term "Senior
         Debt" shall include, without limitation, all Designated Senior Debt,
         and shall not include Indebtedness of the Company to any Subsidiary.

                 "Significant Subsidiary" means any Subsidiary which is a
         "significant subsidiary" within the meaning of Rule 405 under the
         Securities Act.

                 "Special Record Date" for the payment of any Defaulted Interest
         means a date fixed by the Trustee pursuant to Section 2.17 hereof.

                 "Stated Maturity" means the date specified in any Security as
         the fixed date for the payment of principal on such Security or on
         which an installment of interest (including Liquidated Damages, if any)
         on such Security is due and payable.

                 "Subsidiary" means a corporation more than 50% of the
         outstanding voting stock of which is owned, directly or indirectly, by
         the Company or by one or more other Subsidiaries, or by the Company and
         one or more other Subsidiaries. For the purposes of this definition
         only, "voting stock" means stock which ordinarily has voting power for
         the election of directors, whether at all times or only so long as no
         senior class of stock has such voting power by reason of any
         contingency.

                 "TIA" means the Trust Indenture Act of 1939 (15 U.S. Code
         Section 77aaa-77bbbb), as in effect on the date of this Indenture;
         provided, however, that in the event the TIA is amended after such
         date, "TIA" means, to the extent required by such amendment, the Trust
         Indenture Act of 1939, as so amended, or any successor statute.

                 "Trading Day" means:

                           (1) if the applicable security is listed or admitted
         for trading on the New York Stock Exchange or another national security
         exchange, a day on which the New York Stock Exchange or such other
         national security exchange is open for business;

                           (2) if the applicable security is quoted on the
         Nasdaq National Market, a day on which trades may be made thereon; or



                                       12
<PAGE>


                           (3) if the applicable security is not so listed,
         admitted for trading or quoted, any day other than a Saturday or Sunday
         or a day on which banking institutions in the State of New York are
         authorized or obligated by law or executive order to close.

                 "Trading Price" of a security on any date of determination
         means:

                           (1) the closing sale price (or, if no closing sale
         price is reported, the last reported sale price) of such security on
         the New York Stock Exchange on such date;

                           (2) if such security is not listed for trading on the
         New York Stock Exchange on any such date, the closing sale price as
         reported in the composite transactions for the principal U.S.
         securities exchange on which such security is so listed;

                           (3) if such security is not so listed on a U.S.
         national or regional securities exchange, the closing sale price as
         reported by the NASDAQ National Market;

                           (4) if such security is not so reported, the last
         price quoted by Interactive Data Corporation for such security or, if
         Interactive Data Corporation is not quoting such price, a similar
         quotation service selected by the Company;

                           (5) if such security is not so quoted, the average of
         the mid-point of the last bid and ask prices for such security from at
         least two dealers recognized as market-makers for such security; or

                           (6) if such security is not so quoted, the average of
         the last bid and ask prices for such security from a Reference Dealer.

                 "Transfer Agent" means any Person, which may be the Company,
         authorized by the Company to exchange or register the transfer of
         Securities.

                 "Trigger Event" has the meaning specified in Section 12.4(d)
         hereof.

                 "Trustee" means the Person named as the "Trustee" in the first
         paragraph of this instrument until a successor Trustee shall have
         become such pursuant to the applicable provisions of this Indenture,
         and thereafter "Trustee" shall mean such successor Trustee.

                 "U.S. Government Obligations" means: (1) direct obligations of
         the United States of America for the payment of which the full faith
         and credit of the United States of America is pledged or (2)
         obligations of a person controlled or supervised by and acting as an
         agency or instrumentality of the United States of America, the payment
         of which is unconditionally guaranteed as a full faith and credit
         obligation by the United States of America and which in either case,
         are non-callable at the option of the issuer thereof.

                 "Vice President", when used with respect to the Company, means
         any vice president, whether or not designated by a number or a word or
         words added before or after the title "vice president".



                                       13
<PAGE>


         SECTION 1.2 INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT.

         Whenever this Indenture refers to a provision of the TIA, the provision
is incorporated by reference in and made a part of this Indenture.

         The following TIA terms used in this Indenture have the following
meanings:

         "indenture securities" means the Securities;

         "indenture security holder" means a Holder;

         "indenture to be qualified" means this Indenture;

         "indenture trustee" or "institutional trustee" means the Trustee; and

         "obligor" on the Securities means the Company and any other obligor on
the indenture securities.

         All other TIA terms used in this Indenture that are defined by the TIA,
defined by TIA reference to another statute or defined by SEC rule have the
meanings assigned to them by such definitions.

         SECTION 1.3 RULES OF CONSTRUCTION.

         For all purposes of this Indenture, except as otherwise expressly
provided or unless the context otherwise requires:

                           (1) the terms defined in this Article have the
         meanings assigned to them in this Article and include the plural as
         well as the singular;

                           (2) all accounting terms not otherwise defined herein
         have the meanings assigned to them in accordance with accounting
         principles generally accepted in the United States prevailing at the
         time of any relevant computation hereunder; and

                           (3) the words "herein", "hereof" and "hereunder" and
         other words of similar import refer to this Indenture as a whole and
         not to any particular Article, Section or other subdivision.



                                       14
<PAGE>


                                    ARTICLE 2

                                 THE SECURITIES

         SECTION 2.1 TITLE AND TERMS.

         The Securities shall be known and designated as the "5% Convertible
Subordinated Notes due 2007"of the Company. The aggregate principal amount of
Securities which may be authenticated and delivered under this Indenture is
limited to $200,000,000 (or $230,000,000 if the over-allotment option set forth
in Section 2 of the Purchase Agreement is exercised in full), except for
securities authenticated and delivered upon registration of, transfer of, or in
exchange for, or in lieu of other Securities pursuant to Section 2.7, 2.8, 2.9,
2.12, 7.5, 10.8, 11.1 or 12.2 hereof. The Securities shall be issuable in
denominations of $1,000 or integral multiples thereof.

         The Securities shall mature on February 8, 2007.

         Interest shall accrue from February 8, 2000 at the Interest Rate until
the principal thereof is paid or made available for payment. Interest shall be
payable semiannually in arrears on February 8 and August 8 in each year,
commencing August 8, 2000.

         Interest on the Securities shall be computed (i) for any full
semiannual period for which a particular Interest Rate is applicable on the
basis of a 360-day year of twelve 30-day months and (ii) for any period for
which a particular Interest Rate is applicable shorter than a full semiannual
period for which interest is calculated, on the basis of a 30-day month and, for
such periods of less than a month, the actual number of days elapsed over a
30-day month. For purposes of determining the Interest Rate, the Trustee may
assume that a Reset Transaction has not occurred unless the Trustee has received
an Officers' Certificate stating that a Reset Transaction has occurred and
specifying the Adjusted Interest Rate then in effect.

         A Holder of any Security at the close of business on a Regular Record
Date shall be entitled to receive interest (including Liquidated Damages, if
any) on such Security on the corresponding Interest Payment Date. A Holder of
any Security which is converted after the close of business on a Regular Record
Date and prior to the corresponding Interest Payment Date (other than any
Security whose Maturity is prior to such Interest Payment Date) shall be
entitled to receive interest (including Liquidated Damages, if any) on the
principal amount of such Security, notwithstanding the conversion of such
Security prior to such Interest Payment Date. However, any such Holder which
surrenders any such Security for conversion during the period between the close
of business on such Regular Record Date and ending with the opening of business
on the corresponding Interest Payment Date shall be required to pay the Company
an amount equal to the interest (including Liquidated Damages, if any) on the
principal amount of such Security so converted, which is payable by the Company
to such Holder on such Interest Payment Date, at the time such Holder surrenders
such Security for conversion. Notwithstanding the foregoing, any such Holder
which surrenders for conversion any Security which has been called for
redemption by the Company in a notice of redemption given by the Company
pursuant to Section 10.5 hereof shall be entitled to receive (and retain) such
interest (including Liquidated Damages, if any) and need not pay the Company an
amount equal to the interest (including



                                       15
<PAGE>


Liquidated Damages, if any) on the principal amount of such Security so
converted at the time such Holder surrenders such Security for conversion.

         Principal of, and premium, if any, and interest on, Global Securities
shall be payable to the Depositary in immediately available funds.

         Principal and premium, if any, on Physical Securities shall be payable
at the office or agency of the Company maintained for such purpose, initially
the Corporate Trust Office of the Trustee. Interest on Physical Securities will
be payable by (i) U.S. Dollar check drawn on a bank in The City of New York
mailed to the address of the Person entitled thereto as such address shall
appear in the Register, or (ii) upon application to the Registrar not later than
the relevant Record Date by a Holder of an aggregate principal amount in excess
of $5,000,000, wire transfer in immediately available funds.

         The Securities shall be redeemable at the option of the Company as
provided in Article 10 hereof.

         The Securities shall have a Repurchase Right exercisable at the option
of Holders as provided in Article 11 hereof.

         The Securities shall be convertible as provided in Article 12 hereof.

         The Securities shall be subordinated in right of payment to Senior Debt
of the Company as provided in Article 13 hereof.

         SECTION 2.2 FORM OF SECURITIES.

         The Securities and the Trustee's certificate of authentication to be
borne by such Securities shall be substantially in the form annexed hereto as
Exhibit A, which is incorporated in and made a part of this Indenture. The terms
and provisions contained in the form of Security shall constitute, and are
hereby expressly made, a part of this Indenture and to the extent applicable,
the Company and the Trustee, by their execution and delivery of this Indenture,
expressly agree to such terms and provisions and to be bound thereby.

         Any of the Securities may have such letters, numbers or other marks of
identification and such notations, legends and endorsements as the officers
executing the same may approve (execution thereof to be conclusive evidence of
such approval) and as are not inconsistent with the provisions of this
Indenture, or as may be required to comply with any law or with any rule or
regulation made pursuant thereto or with any rule or regulation of any
securities exchange or automated quotation system on which the Securities may be
listed or designated for issuance, or to conform to usage.

         The Securities will be offered and sold only to QIBs in reliance on
Rule 144A and shall be issued initially only in the form of one or more
permanent Global Securities (each, a "Global Security") in registered form
without interest coupons. The Global Securities shall be:



                                       16
<PAGE>


                           (1) duly executed by the Company and authenticated by
         the Trustee as hereinafter provided;

                           (2) registered in the name of the Depositary (or its
         nominee) for credit to the respective accounts of the Holders at the
         Depositary; and

                           (3) deposited with the Trustee, as custodian for the
         Depositary.

         The Global Securities shall be substantially in the form of Security
set forth in Exhibit A annexed hereto (including the text and schedule called
for by footnotes 1 and 2 thereto). The aggregate principal amount of the Global
Securities may from time to time be increased or decreased by adjustments made
on the records of the Trustee, as custodian for the Depositary (or its nominee),
in accordance with the instructions given by the Holder thereof, as hereinafter
provided.

         Securities issued in exchange for interests in the Global Securities
pursuant to Section 2.8(d) hereof shall be issued in the form of permanent
definitive Securities (the "Physical Securities") in registered form without
interest coupons. The Physical Securities shall be substantially in the form set
forth in Exhibit A annexed hereto.

         The Securities shall be typed, printed, lithographed or engraved or
produced by any combination of these methods or may be produced in any other
manner permitted by the rules of any securities exchange on which the Securities
may be listed, all as determined by the Officers executing such Securities, as
evidenced by their execution of such Securities.

         SECTION 2.3 LEGENDS.

         (A)      RESTRICTED SECURITIES LEGENDS.

         Each Security issued hereunder shall, upon issuance, bear the legend
set forth in Section 2.3(a)(i) or Section 2.3(a)(ii) (each, a "Restricted
Securities Legend"), as the case may be, and such legend shall not be removed
except as provided in Section 2.3(a)(iii). Each Security that bears or is
required to bear the Restricted Securities Legend set forth in Section 2.3(a)(i)
(together with any Common Stock issued upon conversion of the Securities and
required to bear the Restricted Securities Legend set forth in Section
2.3(a)(ii), collectively, the "Restricted Securities") shall be subject to the
restrictions on transfer set forth in this Section 2.3(a) (including the
Restricted Securities Legend set forth below), and the Holder of each such
Restricted Security, by such Holder's acceptance thereof, shall be deemed to
have agreed to be bound by all such restrictions on transfer.

         As used in Section 2.3(a), the term "transfer" encompasses any sale,
pledge, transfer or other disposition whatsoever of any Restricted Security.

                     (i) Restricted Securities Legend for Securities.



                                       17
<PAGE>


         Except as provided in Section 2.3(a)(iii), until two years after the
original issuance date of any Security, any certificate evidencing such Security
(and all securities issued in exchange therefor or substitution thereof, other
than Common Stock, if any, issued upon conversion thereof which shall bear the
legend set forth in Section 2.3(a)(ii), if applicable) shall bear a Restricted
Securities Legend in substantially the following form:

         THE SECURITY EVIDENCED BY THIS CERTIFICATE HAS NOT BEEN REGISTERED
         UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR
         ANY STATE SECURITIES LAWS, AND MAY NOT BE OFFERED OR SOLD WITHIN THE
         UNITED STATES OR TO, OR FOR THE ACCOUNT OR BENEFIT OF, U.S. PERSONS
         EXCEPT AS SET FORTH IN THE FOLLOWING SENTENCE. BY ACQUISITION HEREOF,
         THE HOLDER (1) REPRESENTS THAT IT IS A "QUALIFIED INSTITUTIONAL BUYER"
         AS DEFINED IN RULE 144A UNDER THE SECURITIES ACT; (2) AGREES THAT IT
         WILL NOT WITHIN TWO YEARS AFTER THE ORIGINAL ISSUANCE OF THIS SECURITY
         RESELL OR OTHERWISE TRANSFER THE SECURITY EVIDENCED HEREBY OR THE
         COMMON STOCK ISSUABLE UPON CONVERSION OF SUCH SECURITY EXCEPT (A) TO
         THE COMPANY OR ANY SUBSIDIARY THEREOF, (B) TO A QUALIFIED INSTITUTIONAL
         BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT, (C)
         PURSUANT TO THE EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER
         THE SECURITIES ACT (IF AVAILABLE) OR (D) PURSUANT TO A REGISTRATION
         STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT
         AND WHICH CONTINUES TO BE EFFECTIVE AT THE TIME OF SUCH TRANSFER; AND
         (3) AGREES THAT IT WILL DELIVER TO EACH PERSON TO WHOM THE SECURITY
         EVIDENCED HEREBY IS TRANSFERRED (OTHER THAN A TRANSFER PURSUANT TO
         CLAUSE 2(D) ABOVE) A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS LEGEND.
         IN CONNECTION WITH ANY TRANSFER OF THE SECURITY EVIDENCED HEREBY WITHIN
         TWO YEARS AFTER THE ORIGINAL ISSUANCE OF SUCH SECURITY (OTHER THAN A
         TRANSFER PURSUANT TO CLAUSE (2)(D) ABOVE), THE HOLDER MUST CHECK THE
         APPROPRIATE BOX SET FORTH ON THE REVERSE HEREOF RELATING TO THE MANNER
         OF SUCH TRANSFER AND SUBMIT THIS CERTIFICATE TO THE TRUSTEE (OR ANY
         SUCCESSOR TRUSTEE, AS APPLICABLE). IF THE PROPOSED TRANSFER IS PURSUANT
         TO CLAUSE (2)(C) ABOVE, THE HOLDER MUST, PRIOR TO SUCH TRANSFER,
         FURNISH TO THE TRUSTEE (OR ANY SUCCESSOR TRUSTEE, AS APPLICABLE), SUCH
         CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS THE COMPANY MAY
         REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS BEING MADE PURSUANT
         TO AN EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE
         REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. THIS LEGEND WILL BE
         REMOVED UPON THE EARLIER OF THE TRANSFER OF THE SECURITY EVIDENCED
         HEREBY PURSUANT TO CLAUSE (2)(D) ABOVE OR THE EXPIRATION OF TWO YEARS
         FROM THE ORIGINAL ISSUANCE OF THE SECURITY EVIDENCED HEREBY.



                                       18
<PAGE>


         AS USED HEREIN, THE TERMS "UNITED STATES" AND "U.S. PERSON" HAVE THE
         MEANINGS GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT.

                     (ii) Restricted Securities Legend for Common Stock Issued
         Upon Conversion of the Securities.

         Until two years after the original issuance date of any Security, any
stock certificate representing Common Stock issued upon conversion of such
Security shall bear a Restricted Securities Legend in substantially the
following form:

         THE SECURITY EVIDENCED HEREBY HAS NOT BEEN REGISTERED UNDER THE
         SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR ANY STATE
         SECURITIES LAWS, AND MAY NOT BE OFFERED OR SOLD WITHIN THE UNITED
         STATES OR TO, OR FOR THE ACCOUNT OR BENEFIT OF, U.S. PERSONS EXCEPT AS
         SET FORTH IN THE FOLLOWING SENTENCE. THE HOLDER HEREOF AGREES THAT
         UNTIL THE EXPIRATION OF TWO YEARS AFTER THE ORIGINAL ISSUANCE OF THE
         SECURITY UPON THE CONVERSION OF WHICH THE COMMON STOCK EVIDENCED HEREBY
         WAS ISSUED, (1) IT WILL NOT RESELL OR OTHERWISE TRANSFER THE SECURITY
         EXCEPT (A) TO THE COMPANY OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO
         THE EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE
         SECURITIES ACT (IF AVAILABLE) OR (C) PURSUANT TO A REGISTRATION
         STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT
         AND WHICH CONTINUES TO BE EFFECTIVE AT THE TIME OF SUCH TRANSFER; (2)
         PRIOR TO ANY SUCH TRANSFER OTHER THAN A TRANSFER PURSUANT TO CLAUSE
         1(C) ABOVE, IT WILL FURNISH TO SUCH TRANSFER AGENT (OR ANY SUCCESSOR
         TRANSFER AGENT, AS APPLICABLE), SUCH CERTIFICATIONS, LEGAL OPINIONS OR
         OTHER INFORMATION AS THE COMPANY MAY REASONABLY REQUIRE TO CONFIRM THAT
         SUCH TRANSFER IS BEING MADE PURSUANT TO AN EXEMPTION FROM, OR IN A
         TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE
         SECURITIES ACT; AND (3) IT WILL DELIVER TO EACH PERSON TO WHOM THE
         COMMON STOCK EVIDENCED HEREBY IS TRANSFERRED (OTHER THAN A TRANSFER
         PURSUANT TO A CLAUSE (1)(C) ABOVE) A NOTICE SUBSTANTIALLY TO THE EFFECT
         OF THIS LEGEND. THIS LEGEND WILL BE REMOVED UPON THE EARLIER OF THE
         TRANSFER OF THE COMMON STOCK EVIDENCED HEREBY PURSUANT TO CLAUSE (1)(C)
         ABOVE OR THE EXPIRATION OF TWO YEARS FROM THE ORIGINAL ISSUANCE OF THE
         SECURITY UPON THE CONVERSION OF WHICH THE COMMON STOCK EVIDENCED HEREBY
         WAS ISSUED. AS USED HEREIN, THE TERMS "UNITED STATES" AND "U.S. PERSON"
         HAVE THE MEANINGS GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES
         ACT.

                     (iii) Removal of the Restricted Securities Legends.



                                       19
<PAGE>


         Each Security or share of Common Stock issued upon conversion of such
Security shall bear the Restricted Securities Legend set forth in Section
2.3(a)(i) or 2.3(a)(ii), as the case may be, until the earlier of:

                                    (A) two years after the original issuance
                           date of such Security;

                                    (B) such Security or Common Stock has been
                           sold pursuant to a registration statement that has
                           been declared effective under the Securities Act (and
                           which continues to be effective at the time of such
                           sale); or

                                    (C) such Common Stock has been issued upon
                           conversion of Securities that have been sold pursuant
                           to a registration statement that has been declared
                           effective under the Securities Act (and which
                           continues to be effective at the time of such sale).

The Holder must give notice thereof to the Trustee and any transfer agent for
the Common Stock, as applicable.

         Notwithstanding the foregoing, the Restricted Securities Legend may
be removed if there is delivered to the Company such satisfactory evidence,
which may include an opinion of independent counsel, as may be reasonably
required by the Company that neither such legend nor the restrictions on
transfer set forth therein are required to ensure that transfers of such
Security will not violate the registration requirements of the Securities
Act. Upon provision of such satisfactory evidence, the Trustee, at the
written direction of the Company, shall authenticate and deliver in exchange
for such Securities another Security or Securities having an equal aggregate
principal amount that does not bear such legend. If the Restricted Securities
Legend has been removed from a Security as provided above, no other Security
issued in exchange for all or any part of such Security shall bear such
legend, unless the Company has reasonable cause to believe that such other
Security is a "restricted security" within the meaning of Rule 144 and
instructs the Trustee in writing to cause a Restricted Securities Legend to
appear thereon.

         Any Security (or security issued in exchange or substitution thereof)
as to which such restrictions on transfer shall have expired in accordance with
their terms or as to which the conditions for removal of the Restricted
Securities Legend set forth in Section 2.3(a)(i) as set forth therein have been
satisfied may, upon surrender of such Security for exchange to the Registrar in
accordance with the provisions of Section 2.7 hereof, be exchanged for a new
Security or Securities, of like tenor and aggregate principal amount, which
shall not bear the Restricted Securities Legend required by Section 2.3(a)(i).

         Any such Common Stock as to which such restrictions on transfer shall
have expired in accordance with their terms or as to which the conditions for
removal of the Restricted Securities Legend set forth in Section 2.3(a)(ii) as
set forth therein have been satisfied may, upon surrender of the certificates
representing such shares of Common Stock for exchange in accordance with the
procedures of the transfer agent for the Common Stock, be exchanged for a new
certificate or



                                       20
<PAGE>


certificates for a like aggregate number of shares of Common Stock, which shall
not bear the Restricted Securities Legend required by Section 2.3(a)(ii).

         (b)      GLOBAL SECURITY LEGEND.

         Each Global Security shall also bear the following legend on the face
thereof:

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE
DEPOSITORY TRUST COMPANY ("DTC") TO INHALE THERAPEUTIC SYSTEMS, INC. (OR ITS
SUCCESSOR) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, CONVERSION OR
PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR
IN SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND
ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED
BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE
HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

         SECTION 2.4 EXECUTION, AUTHENTICATION, DELIVERY AND DATING.

         Two Officers shall execute the Securities on behalf of the Company by
manual or facsimile signature. If an Officer whose signature is on a Security no
longer holds that office at the time the Security is authenticated, the Security
shall be valid nevertheless.

         At any time and from time to time after the execution and delivery of
this Indenture, the Company may deliver Securities executed by the Company to
the Trustee for authentication, together with a Company Order for the
authentication and delivery of such Securities, and the Trustee in accordance
with such Company Order shall authenticate and deliver such Securities as in
this Indenture provided and not otherwise.

         Each Security shall be dated the date of its authentication.

         No Security shall be entitled to any benefit under this Indenture, or
be valid or obligatory for any purpose, unless there appears on such Security a
certificate of authentication substantially in the form provided for herein
executed by or on behalf of the Trustee by manual signature, and such
certificate upon any Security shall be conclusive evidence, and the only
evidence, that such Security has been duly authenticated and delivered
hereunder.

         The Trustee may appoint an authenticating agent or agents reasonably
acceptable to the Company with respect to the Securities. Unless limited by the
terms of such appointment, an authenticating agent may authenticate Securities
whenever the Trustee may do so. Each reference in this Indenture to
authentication by the Trustee includes authentication by such agent.



                                       21
<PAGE>


         SECTION 2.5 REGISTRAR AND PAYING AGENT.

         The Company shall maintain an office or agency where Securities may be
presented for registration of transfer or for exchange (the "Registrar") and an
office or agency where Securities may be presented for payment (the "Paying
Agent"). The Registrar shall keep a register of the Securities (the "Register")
and of their transfer and exchange. The Company may appoint one or more
co-Registrars and one or more additional Paying Agents for the Securities. The
term "Paying Agent" includes any additional paying agent and the term
"Registrar" includes any additional registrar. The Company may change any Paying
Agent or Registrar without prior notice to any Holder.

         The Company will cause each Paying Agent (other than the Trustee) to
execute and deliver to the Trustee an instrument in which such Paying Agent
shall agree with the Trustee, subject to the provisions of this Section, that
such Paying Agent will:

                           (1) hold all sums held by it for the payment of the
         principal of and premium, if any, or interest (including Liquidated
         Damages, if any) on Securities in trust for the benefit of the Persons
         entitled thereto until such sums shall be paid to such Persons or
         otherwise disposed of as provided in this Indenture;

                           (2) give the Trustee notice of any Default by the
         Company in the making of any payment of principal and premium, if any,
         or interest (including Liquidated Damages, if any); and

                           (3) at any time during the continuance of any such
         Default, upon the written request of the Trustee, forthwith pay to the
         Trustee all sums so held in trust by such Paying Agent.

         The Company shall give prompt written notice to the Trustee of the name
and address of any Agent who is not a party to this Indenture. If the Company
fails to appoint or maintain another entity as Registrar or Paying Agent, the
Trustee shall act as such. The Company or any Affiliate of the Company may act
as Paying Agent or Registrar; provided, however, that none of the Company, its
subsidiaries or the Affiliates of the foregoing shall act:

                     (i) as Paying Agent in connection with redemptions, offers
         to purchase and discharges, as otherwise specified in this Indenture,
         and

                     (ii)as Paying Agent or Registrar if a Default or Event of
         Default has occurred and is continuing.

         The Company hereby initially appoints the Trustee as Registrar and
Paying Agent for the Securities.


                                       22
<PAGE>


         SECTION 2.6 PAYING AGENT TO HOLD ASSETS IN TRUST.

         Not later than 11:00 a.m. (New York City time) on each due date of the
principal, premium, if any, and interest (including Liquidated Damages, if any)
on any Securities, the Company shall deposit with one or more Paying Agents
money in immediately available funds sufficient to pay such principal, premium,
if any, and interest (including Liquidated Damages, if any) so becoming due. The
Company at any time may require a Paying Agent to pay all money held by it to
the Trustee. Upon payment over to the Trustee, the Paying Agent (if other than
the Company) shall have no further liability for the money so paid over to the
Trustee.

         If the Company shall act as a Paying Agent, it shall, prior to or on
each due date of the principal of and premium, if any, or interest (including
Liquidated Damages, if any) on any of the Securities, segregate and hold in
trust for the benefit of the Holders a sum sufficient with monies held by all
other Paying Agents, to pay the principal and premium, if any, or interest
(including Liquidated Damages, if any) so becoming due until such sums shall be
paid to such Persons or otherwise disposed of as provided in this Indenture, and
shall promptly notify the Trustee of its action or failure to act.

         SECTION 2.7 GENERAL PROVISIONS RELATING TO TRANSFER AND EXCHANGE.

         The Securities are issuable only in registered form. A Holder may
transfer a Security only by written application to the Registrar stating the
name of the proposed transferee and otherwise complying with the terms of this
Indenture. No such transfer shall be effected until, and such transferee shall
succeed to the rights of a Holder only upon, final acceptance and registration
of the transfer by the Registrar in the Register. Furthermore, any Holder of a
Global Security shall, by acceptance of such Global Security, agree that
transfers of beneficial interests in such Global Security may be effected only
through a book-entry system maintained by the Holder of such Global Security (or
its agent) and that ownership of a beneficial interest in the Security shall be
required to be reflected in a book-entry. Notwithstanding the foregoing, in the
case of a Restricted Security, a beneficial interest in a Global Security being
transferred in reliance on an exemption from the registration requirements of
the Securities Act other than in accordance with Rule 144 and Rule 144A may only
be transferred for a Physical Security.

         When Securities are presented to the Registrar with a request to
register the transfer or to exchange them for an equal aggregate principal
amount of Securities of other authorized denominations, the Registrar shall
register the transfer or make the exchange as requested if its requirements for
such transactions are met (including that such Securities are duly endorsed or
accompanied by a written instrument of transfer duly executed by the Holder
thereof or by an attorney who is authorized in writing to act on behalf of the
Holder). Subject to Section 2.4 hereof, to permit registrations of transfers and
exchanges, the Company shall execute and the Trustee shall authenticate
Securities at the Registrar's request. No service charge shall be made for any
registration of transfer or exchange or redemption of the Securities, but the
Company may require payment of a sum sufficient to cover any transfer tax or
similar governmental charge payable in connection therewith (other than any such
transfer taxes or other similar governmental charge payable upon exchanges
pursuant to Section 2.14, 7.5 or 10.8 hereof).



                                       23
<PAGE>


         Neither the Company nor the Registrar shall be required to exchange or
register a transfer of any Securities:

                           (1) for a period of 15 Business Days prior to the day
         of any selection of Securities for redemption under Article 10 hereof;

                           (2) so selected for redemption or, if a portion of
         any Security is selected for redemption, such portion thereof selected
         for redemption; or

                           (3) surrendered for conversion or, if a portion of
         any Security is surrendered for conversion, such portion thereof
         surrendered for conversion.

         SECTION 2.8       BOOK-ENTRY PROVISIONS FOR THE GLOBAL SECURITIES.

         (a)      The Global Securities initially shall:

                     (i) be registered in the name of the Depositary (or a
         nominee thereof);

                     (ii)be delivered to the Trustee as custodian for such
         Depositary; and

                     (iii) bear the Restricted Securities Legend as set forth in
         Section 2.3(a)(i) hereof.

         Members of, or participants in, the Depositary ("DTC Participants")
shall have no rights under this Indenture with respect to any Global Security
held on their behalf by the Depositary, or the Trustee as its custodian, or
under such Global Security, and the Depositary may be treated by the Company,
the Trustee and any agent of the Company or the Trustee as the absolute owner of
such Global Security for all purposes whatsoever. Notwithstanding the foregoing,
nothing contained herein shall prevent the Company, the Trustee or any agent of
the Company or Trustee from giving effect to any written certification, proxy or
other authorization furnished by the Depositary or impair, as between the
Depositary and the DTC Participants, the operation of customary practices
governing the exercise of the rights of a Holder of any Security.

         (b) The registered Holder of a Global Security may grant proxies and
otherwise authorize any Person, including DTC Participants and Persons that may
hold interests through DTC Participants, to take any action which a Holder is
entitled to take under this Indenture or the Securities.

         (c) A Global Security may not be transferred, in whole or in part, to
any Person other than the Depositary (or a nominee thereof), and no such
transfer to any such other Person may be registered. Beneficial interests in a
Global Security may be transferred in accordance with the rules and procedures
of the Depositary and the provisions of Section 2.9 hereof.

         (d) If at any time:

                     (i) the Depositary notifies the Company in writing that it
         is no longer willing or able to continue to act as Depositary for the
         Global Securities, or the Depositary ceases to



                                       24
<PAGE>


         be a "clearing agency" registered under the Exchange Act and a
         successor depositary for the Global Securities is not appointed by the
         Company within 90 days of such notice or cessation;

                     (ii) the Company, at its option, notifies the Trustee in
         writing that it elects to cause the issuance of the Securities in
         definitive form under this Indenture in exchange for all or any part of
         the Securities represented by a Global Security or Global Securities;
         or

                     (iii) an Event of Default has occurred and is continuing
         and the Registrar has received a request from the Depositary for the
         issuance of Physical Securities in exchange for such Global Security or
         Global Securities,

the Depositary shall surrender such Global Security or Global Securities to the
Trustee for cancellation and the Company shall execute, and the Trustee, upon
receipt of an Officers' Certificate and Company Order for the authentication and
delivery of Securities, shall authenticate and deliver in exchange for such
Global Security or Global Securities, Physical Securities of like tenor as that
of the Global Securities in an aggregate principal amount equal to the aggregate
principal amount of such Global Security or Global Securities. Such Physical
Securities shall be registered in such names as the Depositary shall identify in
writing as the beneficial owners of the Securities represented by such Global
Security or Global Securities (or any nominee thereof).

         Notwithstanding the foregoing, in connection with any transfer of
beneficial interests in a Global Security to beneficial owners pursuant to
Section 2.8(d) hereof, the Registrar shall reflect on its books and records the
date and a decrease in the principal amount of such Global Security in an amount
equal to the principal amount of the beneficial interest in such Global Security
to be transferred.

         SECTION 2.9 SPECIAL TRANSFER PROVISIONS.

         Unless a Security is transferred after the time period referred to in
Rule 144(k) under the Securities Act or otherwise sold pursuant to a
registration statement that has been declared effective under the Securities Act
(and which continues to be effective at the time of such sale), the following
provisions shall apply.

         With respect to the registration of any proposed transfer of Securities
to a QIB:

                     (i) If the Securities to be transferred consist of an
         interest in the Global Securities, the transfer of such interest may be
         effected only through the book-entry system maintained by the
         Depositary.

                     (ii)If the Securities to be transferred consist of Physical
         Securities, the Registrar shall register the transfer if such transfer
         is being made by a proposed transferor who has checked the box provided
         for on the form of Security stating, or has otherwise advised the
         Company and the Registrar in writing, that the sale has been made in



                                       25
<PAGE>


         compliance with the provisions of Rule 144A to a transferee who has
         signed the certification provided for on the form of Security stating
         or has otherwise advised the Company and the Registrar in writing that:

                                    (A) it is purchasing the Securities for its
                           own account or an account with respect to which it
                           exercises sole investment discretion, in each case
                           for investment and not with a view to distribution;

                                    (B) it and any such account is a QIB within
                           the meaning of Rule 144A;

                                    (C) it is aware that the sale to it is being
                           made in reliance on Rule 144A;

                                    (D) it acknowledges that it has received
                           such information regarding the Company as it has
                           requested pursuant to Rule 144A or has determined not
                           to request such information; and

                                    (E) it is aware that the transferor is
                           relying upon its foregoing representations in order
                           to claim the exemption from registration provided by
                           Rule 144A.

         In addition, the Registrar shall reflect on its books and records the
date and an increase in the principal amount of the Global Securities in an
amount equal to the principal amount of the Physical Securities to be
transferred, and the Trustee shall cancel the Physical Securities so
transferred.

         By its acceptance of any Security bearing the Restricted Securities
Legend, each Holder of such a Security acknowledges the restrictions on transfer
of such Security set forth in this Indenture and agrees that it will transfer
such Security only as provided in this Indenture. The Registrar shall not
register a transfer of any Security unless such transfer complies with the
restrictions on transfer of such Security set forth in this Indenture. The
Registrar shall be entitled to receive and rely on written instructions from the
Company verifying that such transfer complies with such restrictions on
transfer. In connection with any transfer of Securities, each Holder agrees by
its acceptance of the Securities to furnish the Registrar or the Company such
certifications, legal opinions or other information as either of them may
reasonably require to confirm that such transfer is being made pursuant to an
exemption from, or a transaction not subject to, the registration requirements
of the Securities Act; provided that the Registrar shall not be required to
determine (but may rely on a determination made by the Company with respect to)
the sufficiency of any such certifications, legal opinions or other information.

         The Registrar shall retain copies of all letters, notices and other
written communications received pursuant to Section 2.8 hereof or this Section
2.9. The Company shall have the right to inspect and make copies of all such
letters, notices or other written communications at any reasonable time upon the
giving of reasonable written notice to the Registrar.



                                       26
<PAGE>


         SECTION 2.10 HOLDER LISTS.

         The Trustee shall preserve in as current a form as is reasonably
practicable the most recent list available to it of the names and addresses of
Holders and shall otherwise comply with Section 312(a) of the TIA. If the
Trustee is not the Registrar, the Company shall furnish to the Trustee prior to
or on each Interest Payment Date and at such other times as the Trustee may
request in writing a list in such form and as of such date as the Trustee may
reasonably require of the names and addresses of Holders relating to such
Interest Payment Date or request, as the case may be.

         SECTION 2.11 PERSONS DEEMED OWNERS.

         The Company, the Trustee and any agent of the Company or the Trustee
may treat the registered Holder of a Global Security as the absolute owner of
such Global Security for the purpose of receiving payment thereof or on account
thereof and for all other purposes whatsoever, whether or not such Security be
overdue, and notwithstanding any notice of ownership or writing thereon, or any
notice of previous loss or theft or other interest therein. The Company, the
Trustee and any agent of the Company or the Trustee may treat the Person in
whose name any Security is registered as the owner of such Security for the
purpose of receiving payment of principal of and premium, if any, and interest
(including Liquidated Damages, if any) on such Security and for all other
purposes whatsoever, whether or not such Security be overdue, and
notwithstanding any notice of ownership or writing thereon, or any notice of
previous loss or theft or other interest therein.

         SECTION 2.12 MUTILATED, DESTROYED, LOST OR STOLEN SECURITIES.

         If any mutilated Security is surrendered to the Trustee, the Company
shall execute and the Trustee shall authenticate and deliver in exchange
therefor a new Security of like tenor and principal amount and bearing a number
not contemporaneously outstanding.

         If there is delivered to the Company and the Trustee

                          (1) evidence to their satisfaction of the destruction,
         loss or theft of any Security, and

                          (2) such security or indemnity as may be required by
         them to save each of them and any agent of either of them harmless,
         then, in the absence of notice to the Company or the Trustee that such
         Security has been acquired by a bona fide purchaser, the Company shall
         execute and, upon request, the Trustee shall authenticate and deliver,
         in lieu of any such destroyed, lost or stolen Security, a new Security
         of like tenor and principal amount and bearing a number not
         contemporaneously outstanding.

         In case any such mutilated, destroyed, lost or stolen Security has
become or is about to become due and payable, the Company in its discretion, but
subject to any conversion rights, may, instead of issuing a new Security, pay
such Security, upon satisfaction of the condition set forth in the preceding
paragraph.



                                       27
<PAGE>


         Upon the issuance of any new Security under this Section, the Company
may require the payment of a sum sufficient to cover any tax or other
governmental charge that may be imposed in relation thereto and any other
expenses (including the fees and expenses of the Trustee) connected therewith.

         Every new Security issued pursuant to this Section in lieu of any
destroyed, lost or stolen Security shall constitute an original additional
contractual obligation of the Company, whether or not the destroyed, lost or
stolen Security shall be at any time enforceable by anyone, and such new
Security shall be entitled to all the benefits of this Indenture equally and
proportionately with any and all other Securities duly issued hereunder.

         The provisions of this Section are exclusive and shall preclude (to the
extent lawful) all other rights and remedies with respect to the replacement or
payment of mutilated, destroyed, lost or stolen Securities.

         SECTION 2.13 TREASURY SECURITIES.

         In determining whether the Holders of the requisite principal amount of
Outstanding Securities are present at a meeting of Holders for quorum purposes
or have given any request, demand, authorization, direction, notice, consent or
waiver hereunder, Securities owned by the Company or any Affiliate of the
Company shall be disregarded and deemed not to be Outstanding, except that, in
determining whether the Trustee shall be protected in relying upon any such
determination as to the presence of a quorum or upon any such request, demand,
authorization, direction, notice, consent or waiver, only such Securities of
which the Trustee has received written notice and are so owned shall be so
disregarded.

         SECTION 2.14 TEMPORARY SECURITIES.

         Pending the preparation of Securities in definitive form, the Company
may execute and the Trustee shall, upon written request of the Company,
authenticate and deliver temporary Securities (printed or lithographed).
Temporary Securities shall be issuable in any authorized denomination, and
substantially in the form of the Securities in definitive form but with such
omissions, insertions and variations as may be appropriate for temporary
Securities, all as may be determined by the Company. Every such temporary
Security shall be executed by the Company and authenticated by the Trustee upon
the same conditions and in substantially the same manner, and with the same
effect, as the Securities in definitive form. Without unreasonable delay, the
Company will execute and deliver to the Trustee Securities in definitive form
(other than in the case of Securities in global form) and thereupon any or all
temporary Securities (other than any such Securities in global form) may be
surrendered in exchange therefor, at each office or agency maintained by the
Company pursuant to Section 9.2 and the Trustee shall authenticate and deliver
in exchange for such temporary Securities an equal aggregate principal amount of
Securities in definitive form. Such exchange shall be made by the Company at its
own expense and without any charge therefor. Until so exchanged, the temporary
Securities shall in all respects be entitled to the same benefits and subject to
the same limitations under this Indenture as Securities in definitive form
authenticated and delivered hereunder.



                                       28
<PAGE>


         SECTION 2.15 CANCELLATION.

         All securities surrendered for payment, redemption, repurchase,
conversion, registration of transfer or exchange shall, if surrendered to any
Person other than the Trustee, be delivered to the Trustee. All Securities so
delivered shall be canceled promptly by the Trustee, and no Securities shall be
issued in lieu thereof except as expressly permitted by any of the provisions of
this Indenture. Upon written instructions of the Company, the Trustee shall
destroy canceled Securities and, after such destruction, shall deliver a
certificate of such destruction to the Company. If the Company shall acquire any
of the Securities, such acquisition shall not operate as a redemption or
satisfaction of the indebtedness represented by such Securities unless the same
are delivered to the Trustee for cancellation.

         SECTION 2.16 CUSIP NUMBERS.

         The Company in issuing the Securities may use "CUSIP" numbers (if then
generally in use), and the Trustee shall use CUSIP numbers in notices of
redemption or exchange as a convenience to Holders; provided that any such
notice shall state that no representation is made as to the correctness of such
numbers either as printed on the Securities or as contained in any such notice
and that reliance may be placed only on the other identification numbers printed
on the Securities, and any such redemption shall not be affected by any defect
in or omission of such numbers. The Company shall promptly notify the Trustee of
any change in the CUSIP numbers.

         SECTION 2.17 DEFAULTED INTEREST.

         If the Company fails to make a payment of interest (including
Liquidated Damages, if any) on any Security when due and payable ("Defaulted
Interest"), it shall pay such Defaulted Interest plus (to the extent lawful) any
interest payable on the Defaulted Interest, in any lawful manner. It may elect
to pay such Defaulted Interest, plus any such interest payable on it, to the
Persons who are Holders of such Securities on which the interest is due on a
subsequent Special Record Date. The Company shall notify the Trustee in writing
of the amount of Defaulted Interest proposed to be paid on each such Security.
The Company shall fix any such Special Record Date and payment date for such
payment. At least 15 days before any such Special Record Date, the Company shall
mail to Holders affected thereby a notice that states the Special Record Date,
the Interest Payment Date, and amount of such interest (and such Liquidated
Damages, if any) to be paid.



                                       29
<PAGE>


                                    ARTICLE 3

                           SATISFACTION AND DISCHARGE

         SECTION 3.1 SATISFACTION AND DISCHARGE OF INDENTURE.

         When:

                  (1) The Company shall deliver to the trustee for cancellation
         all securities previously authenticated (other than any securities
         which have been destroyed, lost or stolen and in lieu of, or in
         substitution for which, other securities shall have been authenticated
         and delivered) and not previously canceled, or

                  (2) all the securities not previously canceled or delivered to
         the trustee for cancellation shall have become due and payable, or are
         by their terms to become due and payable within one year or are to be
         called for redemption within one year under arrangements satisfactory
         to the Trustee for the giving of notice of redemption,

                           (A) the Company shall deposit with the Trustee, in
         trust, cash in U.S. dollars and/or U.S. Government Obligations which
         through the payment of interest and principal in respect thereof, in
         accordance with their terms, will provide (and without reinvestment and
         assuming no tax liability will be imposed on such Trustee), not later
         than one day before the due date of any payment of money, an amount in
         cash, sufficient, in the opinion of a nationally recognized firm of
         independent public accountants expressed in a written certification
         thereof delivered to the Trustee, to pay principal of, premium, if any,
         or interest (including Liquidated Damages, if any) on all of the
         Securities (other than any Securities which shall have been mutilated,
         destroyed, lost or stolen and in lieu of or in substitution for which
         other Securities shall have been authenticated and delivered) not
         previously canceled or delivered to the Trustee for cancellation, on
         the dates such payments of principal, premium, if any, or interest
         (including Liquidated Damages, if any) are due to such date of maturity
         or redemption, as the case may be, and

                           (B) the Company shall have delivered to the Trustee
         an Officers' Certificate and an Opinion of Counsel to the effect that
         (x) the Company has received from, or there has been published by, the
         Internal Revenue Service a ruling or (y) since the date of execution of
         this Indenture, there has been a change in the applicable federal
         income tax law, in the case of either clause (x) or (y) to the effect
         that, and based thereon such Opinion of Counsel shall confirm that, the
         Holders will not recognize income, gain or loss for federal income tax
         purposes as a result of such deposit and discharge and will be subject
         to federal income tax on the same amount and in the same manner and at
         the same times as would have been the case if such deposit and
         discharge had not occurred, and



                                       30
<PAGE>


if, in the case of either clause (1) or (2), the Company shall also pay or cause
to be paid all other sums payable hereunder by the Company, then this Indenture
shall cease to be of further effect (except as to:

                           (i) remaining rights of registration of transfer,
                  substitution and exchange and conversion of Securities,

                           (ii) rights hereunder of Holders to receive payments
                  of principal of and premium, if any, and interest (including
                  Liquidated Damages, if any) on, the Securities and the other
                  rights, duties and obligations of Holders, as beneficiaries
                  hereof with respect to the amounts, if any, so deposited with
                  the Trustee, and

                           (iii) the rights, obligations and immunities of the
                  Trustee hereunder),

and the Trustee, on demand of the Company accompanied by an Officers'
Certificate and an Opinion of Counsel and at the cost and expense of the
Company, shall execute proper instruments acknowledging satisfaction of and
discharging this Indenture; provided, however, the Company shall reimburse the
Trustee for all amounts due the Trustee under Section 5.8 hereof and for any
costs or expenses thereafter reasonably and properly incurred by the Trustee and
to compensate the Trustee for any services thereafter reasonably and properly
rendered by the Trustee in connection with this Indenture or the Securities.

         SECTION 3.2 DEPOSITED MONIES TO BE HELD IN TRUST.

         Subject to Section 3.3 hereof, all monies deposited with the Trustee
pursuant to Section 3.1 hereof shall be held in trust and applied by it to the
payment, notwithstanding the provisions of Article 13 hereof, either directly or
through any Paying Agent (including the Company if acting as its own Paying
Agent), to the Holders of the particular Securities for the payment or
redemption of which such monies have been deposited with the Trustee, of all
sums due and to become due thereon for principal, premium, if any, and interest
(including Liquidated Damages, if any). All monies deposited with the Trustee
pursuant to Section 3.1 hereof (and held by it or any Paying Agent) for the
payment of Securities subsequently converted shall be returned to the Company
upon request of the Company.

         SECTION 3.3 RETURN OF UNCLAIMED MONIES.

         The Trustee and the Paying Agent shall pay to the Company any money
held by them for the payment of principal or premium, if any, or interest
(including Liquidated Damages, if any) that remains unclaimed for two years
after the date upon which such payment shall have become due. After payment to
the Company, Holders entitled to the money must look to the Company for payment
as general creditors unless an applicable abandoned property law designates
another Person, and all liability of the Trustee and such Paying Agent with
respect to such money shall cease.



                                       31
<PAGE>


                                    ARTICLE 4

                              DEFAULTS AND REMEDIES

         SECTION 4.1 EVENTS OF DEFAULT.

         An "Event of Default" with respect to the Securities occurs when any of
the following occurs (whatever the reason for such Event of Default and whether
it shall be occasioned by the provisions of Article 13 hereof or be voluntary or
involuntary or be effected by operation of law or pursuant to any judgment,
decree or order of any court or any order, rule or regulation of any
administrative or governmental body):

         (a) the Company defaults in the payment of the principal of or premium,
if any, on any of the Securities when it becomes due and payable at Maturity,
upon redemption or exercise of a Repurchase Right or otherwise, whether or not
such payment is prohibited by Article 13 hereof; or

         (b) the Company defaults in the payment of interest (including
Liquidated Damages, if any) on any of the Securities when it becomes due and
payable and such default continues for a period of 30 days, whether or not such
payment is prohibited by Article 13 hereof; or

         (c) the Company fails to perform or observe any other term, covenant or
agreement contained in the Securities or this Indenture and the default
continues for a period of 60 days after written notice of such failure,
requiring the Company to remedy the same, shall have been given to the Company
by the Trustee or to the Company and the Trustee by the Holders of at least 25%
in aggregate principal amount of the Outstanding Securities; or

         (d) (i) the Company fails to make any payment by the end of the
applicable grace period, if any, after the maturity of any Indebtedness for
borrowed money in an amount in excess of $5,000,000 (provided that such failure
shall not constitute an Event of Default if (1) the Company determines, in good
faith, that a lessor under a lease described in clause (3)(a) of the definition
of Indebtedness breached a covenant under the lease and the Company has given
notice of the breach to the lessor and the Trustee and (2) as a result of the
breach, the Company withholds payment under the lease) (a "Default Exception"),
or (ii) there is an acceleration of any Indebtedness for borrowed money in an
amount in excess of $5,000,000 because of a default with respect to such
Indebtedness (other than a Default Exception) without such Indebtedness having
been discharged or such acceleration having been cured, waived, rescinded or
annulled, in the case of either (i) or (ii) above, for a period of 30 days after
written notice to the Company by the Trustee or to the Company and the Trustee
by Holders of at least 25% in aggregate principal amount of the Outstanding
Securities; or

         (e) the entry by a court having jurisdiction in the premises of (i) a
decree or order for relief in respect of the Company in an involuntary case or
proceeding under any applicable U.S. federal or state bankruptcy, insolvency,
reorganization or other similar law or (ii) a decree or order adjudging the
Company a bankrupt or insolvent, or approving as properly filed a petition
seeking reorganization, arrangement, adjustment or composition of or in respect
of the Company



                                       32
<PAGE>


under any applicable U.S. federal or state law, or appointing a custodian,
receiver, liquidator, assignee, trustee, sequestrator or other similar official
of the Company or of any substantial part of its property, or ordering the
winding up or liquidation of its affairs, and the continuance of any such decree
or order for relief or any such other decree or order unstayed and in effect for
a period of 60 consecutive days; or

         (f) the commencement by the Company of a voluntary case or proceeding
under any applicable U.S. federal or state bankruptcy, insolvency,
reorganization or other similar law or of any other case or proceeding to be
adjudicated a bankrupt or insolvent, or the consent by the Company to the entry
of a decree or order for relief in respect of the Company in an involuntary case
or proceeding under any applicable U.S. federal or state bankruptcy, insolvency,
reorganization or other similar law or to the commencement of any bankruptcy or
insolvency case or proceeding against the Company, or the filing by the Company
of a petition or answer or consent seeking reorganization or relief under any
applicable U.S. federal or state law, or the consent by the Company to the
filing of such petition or to the appointment of or the taking possession by a
custodian, receiver, liquidator, assignee, trustee, sequestrator or other
similar official of the Company or of any substantial part of its property, or
the making by the Company of an assignment for the benefit of creditors, or the
admission by the Company in writing of its inability to pay its debts generally
as they become due, or the taking of corporate action by the Company expressly
in furtherance of any such action.

         SECTION 4.2 ACCELERATION OF MATURITY; RESCISSION AND ANNULMENT.

         If an Event of Default with respect to Outstanding Securities (other
than an Event of Default specified in Section 4.1(e) or 4.1(f) hereof) occurs
and is continuing, the Trustee or the Holders of at least 25% in aggregate
principal amount of the Outstanding Securities, by written notice to the
Company, may declare due and payable 100% of the principal amount of all
Outstanding Securities plus any accrued and unpaid interest to the date of
payment. Upon a declaration of acceleration, such principal and accrued and
unpaid interest to the date of payment shall be immediately due and payable.

         If an Event of Default specified in Section 4.1(e) or 4.1(f) hereof
occurs, all unpaid principal and accrued and unpaid interest (including
Liquidated Damages, if any) on the Outstanding Securities shall become and be
immediately due and payable, without any declaration or other act on the part of
the Trustee or any Holder.

         The Holders of a majority in aggregate principal amount of the
Outstanding Securities by written notice to the Trustee may rescind and annul an
acceleration and its consequences if:

                           (1) all existing Events of Default, other than the
         nonpayment of principal of or interest on the Securities which have
         become due solely because of the acceleration, have been remedied,
         cured or waived, and

                           (2) the rescission would not conflict with any
         judgment or decree of a court of competent jurisdiction;



                                       33
<PAGE>


provided, however, that in the event such declaration of acceleration has been
made based on the existence of an Event of Default under Section 4.1(d) hereof
and such Event of Default has been remedied, cured or waived in accordance with
Section 4.1(d) hereof, then, without any further action by the Holders, such
declaration of acceleration shall be rescinded automatically and the
consequences of such declaration shall be annulled. No such rescission or
annulment shall affect any subsequent Default or impair any right consequent
thereon.

         SECTION 4.3 OTHER REMEDIES.

         If an Event of Default with respect to Outstanding Securities occurs
and is continuing, the Trustee may pursue any available remedy by proceeding at
law or in equity to collect the payment of principal of or interest on the
Securities or to enforce the performance of any provision of the Securities.

         The Trustee may maintain a proceeding in which it may prosecute and
enforce all rights of action and claims under this Indenture or the Securities,
even if it does not possess any of the Securities or does not produce any of
them in the proceeding.

         SECTION 4.4 WAIVER OF PAST DEFAULTS.

         The Holders, either (a) through the written consent of not less than a
majority in aggregate principal amount of the Outstanding Securities, or (b) by
the adoption of a resolution, at a meeting of Holders of the Outstanding
Securities at which a quorum is present, by the Holders of at least a majority
in aggregate principal amount of the Outstanding Securities represented at such
meeting, may, on behalf of the Holders of all of the Securities, waive an
existing Default or Event of Default, except a Default or Event of Default:

                           (1) in the payment of the principal of or premium, if
         any, or interest (including Liquidated Damages, if any) on any Security
         (provided, however, that subject to Section 4.7 hereof, the Holders of
         a majority in aggregate principal amount of the Outstanding Securities
         may rescind an acceleration and its consequences, including any related
         payment default that resulted from such acceleration); or

                           (2) in respect of a covenant or provision hereof
         which, under Section 7.2 hereof, cannot be modified or amended without
         the consent of the Holders of each Outstanding Security affected.

         Upon any such waiver, such Default shall cease to exist, and any Event
of Default arising therefrom shall be deemed to have been cured, for every
purpose of this Indenture; provided, however, that no such waiver shall extend
to any subsequent or other Default or impair any right consequent thereon.

         SECTION 4.5 CONTROL BY MAJORITY.

         The Holders of a majority in aggregate principal amount of the
Outstanding Securities (or such lesser amount as shall have acted as a meeting
pursuant to the provisions of this Indenture)



                                       34
<PAGE>


shall have the right to direct the time, method and place of conducting any
proceeding for any remedy available to the Trustee or exercising any trust or
power conferred on the Trustee. However, the Trustee may refuse to follow any
direction that:

                           (1) conflicts with any law or with this Indenture;

                           (2) the Trustee determines may be unduly prejudicial
         to the rights of the Holders not joining therein, or

                           (3) may expose the Trustee to personal liability.

The Trustee may take any other action deemed proper by the Trustee which is not
inconsistent with such direction.

         SECTION 4.6 LIMITATION ON SUIT.

No Holder of any Security shall have any right to pursue any remedy with respect
to this indenture or the Securities (including, instituting any proceeding,
judicial or otherwise, with respect to this Indenture or for the appointment of
a receiver or trustee) unless:

                           (1) such Holder has previously given written notice
         to the Trustee of an Event of Default that is continuing;

                           (2) the Holders of at least 25% in aggregate
         principal amount of the Outstanding Securities shall have made written
         request to the Trustee to pursue the remedy;

                           (3) such Holder or Holders have offered to the
         Trustee indemnity satisfactory to it against any costs, expenses and
         liabilities incurred in complying with such request;

                           (4) the Trustee has failed to comply with the request
         for 60 days after its receipt of such notice, request and offer of
         indemnity; and

                           (5) during such 60-day period, no direction
         inconsistent with such written request has been given to the Trustee by
         the Holders of a majority in aggregate principal amount of the
         Outstanding Securities (or such amount as shall have acted at a meeting
         pursuant to the provisions of this Indenture);

provided, however, that no one or more of such Holders may use this Indenture to
prejudice the rights of another Holder or to obtain preference or priority over
another Holder.

         SECTION 4.7 UNCONDITIONAL RIGHTS OF HOLDERS TO RECEIVE PAYMENT AND TO
                     CONVERT.

         Notwithstanding any other provision in this Indenture, the Holder of
any Security shall have the right, which is absolute and unconditional, to
receive payment of the principal of and premium, if any, and interest (including
Liquidated Damages, if any) on such Security on the



                                       35
<PAGE>


Stated Maturity expressed in such Security (or, in the case of redemption, on
the Redemption Date, or in the case of the exercise of a Repurchase Right, on
the Repurchase Date) and to convert such Security in accordance with Article 12,
and to bring for the enforcement of any such payment on or after such respective
dates and right to convert, and such rights shall not be impaired or affected
without the consent of such Holder.

         SECTION 4.8 COLLECTION OF INDEBTEDNESS AND SUITS FOR ENFORCEMENT BY THE
                     TRUSTEE.

         The Company covenants that if:

                           (1) a Default or Event of Default is made in the
         payment of any interest (including Liquidated Damages, if any) on any
         Security when such interest (including Liquidated Damages, if any)
         becomes due and payable and such Default or Event of Default continues
         for a period of 30 days, or

                           (2) a Default or Event of Default is made in the
         payment of the principal of or premium, if any, on any Security at the
         Maturity thereof,

the Company will, upon demand of the Trustee, pay to it, for the benefit of the
Holders of such Securities, the whole amount then due and payable (as expressed
therein or as a result of any acceleration effected pursuant to Section 4.2
hereof) on such Securities for principal and premium, if any, and interest
(including Liquidated Damages, if any) and, to the extent that payment of such
interest shall be legally enforceable, interest on any overdue principal and
premium, if any, and on any overdue interest (including Liquidated Damages, if
any), calculated using the Interest Rate, and, in addition thereto, such further
amount as shall be sufficient to cover the costs and expenses of collection,
including the reasonable compensation, expenses, disbursements and advances of
the Trustee, its agents and counsel.

         If the Company fails to pay such amounts forthwith upon such demand,
the Trustee, in its own name and as trustee of an express trust, may institute a
judicial proceeding for the collection of the sums so due and unpaid, may
prosecute such proceeding to judgment or final decree and may enforce the same
against the Company and collect the moneys adjudged or decreed to be payable in
the manner provided by law out of the property of the Company, wherever
situated.

         If an Event of Default occurs and is continuing, the Trustee may in its
discretion proceed to protect and enforce its rights and the rights of the
Holders of Securities by such appropriate judicial proceedings as the Trustee
shall deem most effectual to protect and enforce any such rights, whether for
the specific enforcement of any covenant or agreement in this Indenture or in
aid of the exercise of any power granted herein, or to enforce any other proper
remedy.

         SECTION 4.9 TRUSTEE MAY FILE PROOFS OF CLAIM.

         In case of the pendency of any receivership, insolvency, liquidation,
bankruptcy, reorganization, arrangement, adjustment, composition or other
judicial proceeding relative to the Company or the property of the Company or
its creditors, the Trustee (irrespective of whether the principal of the
Securities shall then be due and payable as therein expressed or by declaration
or



                                       36
<PAGE>


otherwise and irrespective of whether the Trustee shall have made any demand on
the Company for the payment of overdue principal or interest (including
Liquidated Damages, if any)) shall be entitled and empowered, by intervention in
such proceeding or otherwise,

                           (1) to file and prove a claim for the whole amount of
         principal and premium, if any, and interest (including Liquidated
         Damages, if any) owing and unpaid in respect of the Securities and to
         file such other papers or documents as may be necessary or advisable in
         order to have the claims of the Trustee (including any claim for the
         reasonable compensation, expenses, disbursements and advances of the
         Trustee, its agents and counsel) and of the Holders of Securities
         allowed in such judicial proceeding, and

                           (2) to collect and receive any moneys or other
         property payable or deliverable on any such claim and to distribute the
         same;

and any custodian, receiver, assignee, trustee, liquidator, sequestrator or
other similar official in any such judicial proceedings is hereby authorized by
each Holder of Securities to make such payments to the Trustee and, in the event
that the Trustee shall consent to the making of such payments directly to the
Holders of Securities, to pay to the Trustee any amount due to it for the
reasonable compensation, expenses, disbursements and advances of the Trustee,
its agents and counsel and any other amounts due the Trustee under Section 5.8.

         Nothing contained herein shall be deemed to authorize the Trustee to
authorize or consent to or accept, or adopt on behalf of any Holder of a
Security, any plan of reorganization, arrangement, adjustment or composition
affecting the Securities or the rights of any Holder thereof or to authorize the
Trustee to vote in respect of the claim of any Holder of a Security in any such
proceeding.

         SECTION 4.10 RESTORATION OF RIGHTS AND REMEDIES.

         If the Trustee or any Holder of a Security has instituted any
proceeding to enforce any right or remedy under this Indenture and such
proceeding has been discontinued or abandoned for any reason, or has been
determined adversely to the Trustee or to such Holder, then and in every such
case, subject to any determination in such proceeding, the Company, the Trustee
and the Holders of Securities shall be restored severally and respectively to
their former positions hereunder and thereafter all rights and remedies of the
Trustee and the Holders shall continue as though no such proceeding had been
instituted.

         SECTION 4.11 RIGHTS AND REMEDIES CUMULATIVE.

         Except as otherwise provided with respect to the replacement or payment
of mutilated, destroyed, lost or stolen Securities in the last paragraph of
Section 2.12, no right or remedy conferred in this Indenture upon or reserved to
the Trustee or to the Holders of Securities is intended to be exclusive of any
other right or remedy, and every right and remedy shall, to the extent permitted
by law, be cumulative and in addition to every other right and remedy given
hereunder or hereafter existing at law or in equity or otherwise. The assertion
or employment of



                                       37
<PAGE>


any right or remedy hereunder, or otherwise, shall not prevent the concurrent
assertion or employment of any other appropriate right or remedy.

         SECTION 4.12 DELAY OR OMISSION NOT WAIVER.

         No delay or omission of the Trustee or of any Holder of any Security to
exercise any right or remedy accruing upon any Event of Default shall impair any
such right or remedy or constitute a waiver of any such Event of Default or any
acquiescence therein. Every right and remedy given by this Article or by law to
the Trustee or to the Holders of Securities may be exercised from time to time,
and as often as may be deemed expedient, by the Trustee or by the Holders of
Securities, as the case may be.

         SECTION 4.13 APPLICATION OF MONEY COLLECTED.

         Subject to Article 13, any money collected by the Trustee pursuant to
this Article shall be applied in the following order, at the date or dates fixed
by the Trustee and, in case of the distribution of such money on account of
principal or premium, if any, or interest (including Liquidated Damages, if
any), upon presentation of the Securities and the notation thereon of the
payment if only partially paid and upon surrender thereof if fully paid:

                  FIRST:  To the payment of all amounts due the Trustee;

                  SECOND: To the payment of the amounts then due and unpaid for
         principal of and premium, if any, and interest (including Liquidated
         Damages, if any) on the Securities and coupons in respect of which or
         for the benefit of which such money has been collected, ratably,
         without preference or priority of any kind, according to the amounts
         due and payable on such Securities for principal and premium, if any,
         and interest (including Liquidated Damages, if any), respectively; and

                  THIRD:  Any remaining amounts shall be repaid to the Company.

         SECTION 4.14 UNDERTAKING FOR COSTS.

         All parties to this Indenture agree, and each Holder of any Security by
such Holder's acceptance thereof shall be deemed to have agreed, that any court
may in its discretion require, in any suit for the enforcement of any right or
remedy under this Indenture, or in any suit against the Trustee for any action
taken, suffered or omitted by it as Trustee, the filing by any party litigant in
such suit of an undertaking to pay the costs of such suit, and that such court
may in its discretion assess reasonable costs, including reasonable attorneys'
fees, against any party litigant in such suit, having due regard to the merits
and good faith of the claims or defenses made by such party litigant; but the
provisions of this Section shall not apply to any suit instituted by the
Company, to any suit instituted by the Trustee, to any suit instituted by any
Holder, or group of Holders, holding in the aggregate more than 10% in aggregate
principal amount of the Outstanding Securities, or to any suit instituted by any
Holder of any Security for the enforcement of the payment of the principal of or
premium, if any, or interest (including Liquidated Damages, if any) on any
Security on or after the Stated Maturity expressed in such



                                       38
<PAGE>


Security (or, in the case of redemption or exercise of a Repurchase Right, on or
after the Redemption Date) or for the enforcement of the right to convert any
Security in accordance with Article 12.

         SECTION 4.15 WAIVER OF STAY OR EXTENSION LAWS.

         The Company covenants (to the extent that it may lawfully do so) that
it will not at any time insist upon, or plead, or in any manner whatsoever claim
to take the benefit or advantage of, any stay or extension law wherever enacted,
now or at any time hereafter in force, which may affect the covenants or the
performance of this Indenture; and the Company (to the extent that it may
lawfully do so) hereby expressly waives all benefit or advantage of any such law
and covenants that it will not hinder, delay or impede the execution of any
power herein granted to the Trustee, but will suffer and permit the execution of
every such power as though no such law had been enacted.



                                       39
<PAGE>


                                    ARTICLE 5

                                   THE TRUSTEE

         SECTION 5.1 CERTAIN DUTIES AND RESPONSIBILITIES.

         (a)      Except during the continuance of an Event of Default,

                           (1) The Trustee undertakes to perform such duties and
         only such duties as are specifically set forth in this Indenture or the
         TIA, and no implied covenants or obligations shall be read into this
         Indenture against the Trustee; and

                           (2) In the absence of bad faith on its part, the
         Trustee may conclusively rely, as to the truth of the statements and
         the correctness of the opinions expressed therein, upon certificates or
         opinions furnished to the Trustee and conforming to the requirements of
         this Indenture; provided, however, that in the case of any such
         certificates or opinions which by any provision hereof are specifically
         required to be furnished to the Trustee, the Trustee shall examine the
         certificates or opinions to determine whether or not, on their face,
         they conform to the requirements to this Indenture (but need not
         investigate or confirm the accuracy of any facts stated therein).

         (b) In case an Event of Default actually known to a Responsible Officer
of the Trustee has occurred and is continuing, the Trustee shall exercise such
of the rights and powers vested in it by this Indenture, and use the same degree
of care and skill in their exercise, as a prudent person would exercise or use
under the circumstances in the conduct of such person's own affairs.

         (c) No provision of this Indenture shall be construed to relieve the
Trustee from liability for its own negligent action, its own negligent failure
to act, or its own willful misconduct, except that:

                          (1) This paragraph (c) shall not be construed to limit
         the effect of paragraph (a) of this Section 5.1;

                          (2) The Trustee shall not be liable for any error of
         judgment made in good faith by a Responsible Officer, unless it shall
         be proved that the Trustee was negligent in ascertaining the pertinent
         facts; and

                          (3) The Trustee shall not be liable with respect to
         any action taken or omitted to be taken by it in good faith in
         accordance with a direction received by it of the Holders of a majority
         in principal amount of the Outstanding Securities (or such lesser
         amount as shall have acted at a meeting pursuant to the provisions of
         this Indenture) relating to the time, method and place of conducting
         any proceeding for any remedy available to the Trustee, or exercising
         any trust or power conferred upon the Trustee, under this Indenture.



                                       40
<PAGE>


         (d) Whether or not herein expressly so provided, every provision of
this Indenture relating to the conduct or affecting the liability of or
affording protection to the Trustee shall be subject to the provisions of this
Section 5.1.

         (e) No provision of this Indenture shall require the Trustee to expend
or risk its own funds or otherwise incur any liability in the performance of any
of its duties hereunder, or in the exercise of any of its rights or powers. The
Trustee may refuse to perform any duty or exercise any right or power unless it
receives indemnity satisfactory to it against any loss, liability, cost or
expense (including, without limitation, reasonable fees of counsel).

         (f) The Trustee shall not be obligated to pay interest on any money or
other assets received by it unless otherwise agreed in writing with the Company.
Assets held in trust by the Trustee need not be segregated from other funds
except to the extent required by law.

         (g) The Trustee shall not be bound to make any investigation into the
facts or matters stated in any resolution, certificate, statement, instrument,
opinion, report, notice, request, direction, consent, order, bond, debenture,
note, coupon, other evidence of indebtedness or other paper or document, but the
Trustee, in its discretion, may make such further inquiry or investigation into
such facts or matters as it may see fit, and, if the Trustee shall determine to
make such further inquiry or investigation, it shall be entitled to examine the
books, records and premises of the Company, personally or by agent or attorney
at the sole cost of the Company and shall incur no liability or additional
liability of any kind by reason of such inquiry or investigation.

         (h) The Trustee shall not be deemed to have notice or actual knowledge
of any Event of Default or a Registration Default (as such term is defined in
the Registration Rights Agreement) or the obligation of the Company to pay
Liquidated Damages unless a Responsible Officer of the Trustee has actual
knowledge thereof or unless written notice of any event which is in fact a
Default is received by the Trustee pursuant to Section 14.2 hereof, and such
notice references the Securities and this Indenture.

         (i) The rights, privileges, protections, immunities and benefits given
to the Trustee hereunder, including, without limitation, its right to be
indemnified, are extended to, and shall be enforceable by, the Trustee in each
of its capacities hereunder, and each Paying Agent, authenticating agent,
Conversion Agent or Registrar acting hereunder.

         SECTION 5.2 CERTAIN RIGHTS OF TRUSTEE.

         Subject to the provisions of Section 5.1 hereof and subject to Section
315(a) through (d) of the TIA:

                           (1) The Trustee may rely on any document believed by
         it to be genuine and to have been signed or presented by the proper
         person. The Trustee need not investigate any fact or matter stated in
         the document.



                                       41
<PAGE>


                           (2) Before the Trustee acts or refrains from acting,
         it may require an Officers' Certificate or an Opinion of Counsel, or
         both. The Trustee shall not be liable for any action it takes or omits
         to take in good faith in reliance on the Officers' Certificate or
         Opinion of Counsel

                           (3) The Trustee may act through attorneys and agents
         and shall not be responsible for the misconduct or negligence of any
         attorney or agent appointed with due care.

                           (4) The Trustee shall not be liable for any action
         taken or omitted to be taken by it in good faith which it believed to
         be authorized or within the discretion or rights or powers conferred
         upon it by this Indenture, unless the Trustee's conduct constitutes
         negligence.

                           (5) The Trustee may consult with counsel of its
         selection and the advice of such counsel as to matters of law shall be
         full and complete authorization and protection in respect of any action
         taken, omitted or suffered by it hereunder in good faith and in
         accordance with the advice or opinion of such counsel.

                           (6) Unless otherwise specifically provided in this
         Indenture, any demand, request, direction or notice from the Company
         shall be sufficient if signed by an Officer of the Company.

                           (7) The permissive rights of the Trustee to do things
         enumerated in this Indenture shall not be construed as a duty unless so
         specified herein.

         SECTION 5.3 INDIVIDUAL RIGHTS OF TRUSTEE.

         The Trustee in its individual or any other capacity may become the
owner or pledgee of Securities and may otherwise deal with the Company or any
Affiliate of the Company with the same rights it would have if it were not
Trustee. However, in the event that the Trustee acquires any conflicting
interest (as such term is defined in Section 310(b) of the TIA), it must
eliminate such conflict within 90 days, apply to the SEC for permission to
continue as trustee (to the extent permitted under Section 310(b) of the TIA) or
resign. Any agent may do the same with like rights and duties. The Trustee is
also subject to Sections 5.11 and 5.12 hereof.

         SECTION 5.4 MONEY HELD IN TRUST.

         Money held by the Trustee in trust hereunder need not be segregated
from other funds except to the extent required by law. The Trustee shall be
under no liability for interest on any money received by it hereunder except as
otherwise expressly agreed with the Company.

         SECTION 5.5 TRUSTEE'S DISCLAIMER.

         The recitals contained herein and in the Securities (except for those
in the certificate of authentication) shall be taken as the statements of the
Company, and the Trustee assumes no



                                       42
<PAGE>


responsibility for their correctness. The Trustee makes no representations as to
the validity, sufficiency or priority of this Indenture or of the Securities.
The Trustee shall not be accountable for the use or application by the Company
of Securities or the proceeds thereof.

         SECTION 5.6 NOTICE OF DEFAULTS.

         Within 90 days after the occurrence of any Default or Event of Default
hereunder of which the Trustee has received written notice, the Trustee shall
give notice to Holders pursuant to Section 14.2 hereof, unless such Default or
Event of Default shall have been cured or waived; provided, however, that,
except in the case of a Default or Event of Default in the payment of the
principal of or premium, if any, or interest (including Liquidated Damages, if
any), or in the payment of any redemption or repurchase obligation on any
Security, the Trustee shall be protected in withholding such notice if and so
long as Responsible Officers of the Trustee in good faith determine that the
withholding of such notice is in the interest of the Holders.

         SECTION 5.7 REPORTS BY TRUSTEE TO HOLDERS.

         The Trustee shall transmit to Holders such reports concerning the
Trustee and its actions under this Indenture as may be required by Section 313
of the TIA at the times and in the manner provided by the TIA.

         A copy of each report at the time of its mailing to Holders shall be
filed with the SEC, if required, and each stock exchange, if any, on which the
Securities are listed. The Company shall promptly notify the Trustee when the
Securities become listed on any stock exchange.

         SECTION 5.8 COMPENSATION AND INDEMNIFICATION.

         The Company covenants and agrees to pay to the Trustee from time to
time, and the Trustee shall be entitled to, reasonable compensation (which shall
not be limited by any provision of law in regard to the compensation of a
trustee of an express trust) and the Company covenants and agrees to pay or
reimburse the Trustee upon its request for all reasonable expenses,
disbursements and advances incurred or made by or on behalf of it in accordance
with any of the provisions of this Indenture (including the reasonable
compensation and the expenses and disbursements of its counsel and of all agents
and other persons not regularly in its employ), except to the extent that any
such expense, disbursement or advance is due to its negligence or bad faith.
When the Trustee incurs expenses or renders services in connection with an Event
of Default specified in Section 4.1 hereof, the expenses (including the
reasonable charges and expenses of its counsel) and the compensation for the
services are intended to constitute expenses of administration under any
bankruptcy law. The Company also covenants to indemnify the Trustee and its
officers, directors, employees and agents for, and to hold such Persons harmless
against, any loss, liability or expense incurred by them, arising out of or in
connection with the acceptance or administration of this Indenture or the trusts
hereunder or the performance of their duties hereunder, including the costs and
expenses of defending themselves against or investigating any claim of liability
in the premises, except to the extent that any such loss, liability or expense
was due to the negligence or willful misconduct of such Persons. The obligations
of the Company under this Section 5.8 to compensate and indemnify the Trustee
and



                                       43
<PAGE>


its officers, directors, employees and agents and to pay or reimburse such
Persons for expenses, disbursements and advances shall constitute additional
indebtedness hereunder and shall survive the satisfaction and discharge of this
Indenture or the earlier resignation or removal of the Trustee. Such additional
indebtedness shall be a senior claim to that of the Securities upon all property
and funds held or collected by the Trustee as such, except funds held in trust
for the benefit of the Holders of particular Securities, and the Securities are
hereby subordinated to such senior claim. "Trustee" for purposes of this Section
5.8 shall include any predecessor Trustee, but the negligence or willful
misconduct of any Trustee shall not affect the indemnification of any other
Trustee.

         SECTION 5.9 REPLACEMENT OF TRUSTEE.

         A resignation or removal of the Trustee and appointment of a successor
Trustee shall become effective only upon the successor Trustee's acceptance of
appointment as provided in this Section 5.9.

         The Trustee may resign and be discharged from the trust hereby created
by so notifying the Company in writing. The Holders of at least a majority in
aggregate principal amount of Outstanding Securities may remove the Trustee by
so notifying the Trustee and the Company in writing. The Company must remove the
Trustee if:

                             (i) the Trustee fails to comply with Section 5.10
                  hereof or Section 310 of the TIA;

                             (ii) the Trustee becomes incapable of acting.

                             (iii) the Trustee is adjudged a bankrupt or an
                  insolvent or an order for relief is entered with respect to
                  the Trustee under any Bankruptcy Law; or

                             (iv) a Custodian or public officer takes charge of
the Trustee or its property.

         If the Trustee resigns or is removed or if a vacancy exists in the
office of the Trustee for any reason, the Company shall promptly appoint a
successor Trustee. The Trustee shall be entitled to payment of its fees and
reimbursement of its expenses while acting as Trustee. Within one year after the
successor Trustee takes office, the Holders of at least a majority in aggregate
principal amount of Outstanding Securities may appoint a successor Trustee to
replace the successor Trustee appointed by the Company.

         Any Holder may petition any court of competent jurisdiction for the
removal of the Trustee and the appointment of a successor Trustee if the Trustee
fails to comply with Section 5.10 hereof.

         If an instrument of acceptance by a successor Trustee shall not have
been delivered to the Trustee within 30 days after the giving of such notice of
resignation or removal, the resigning or



                                       44
<PAGE>


removed Trustee, as the case may be, may petition, at the expense of the
Company, any court of competent jurisdiction for the appointment of a successor
Trustee.

         A successor Trustee shall deliver a written acceptance of its
appointment to the retiring Trustee and to the Company. Thereupon the
resignation or removal of the retiring Trustee shall become effective, and the
successor Trustee shall have all the rights, powers and duties of the Trustee
under this Indenture. The Company shall mail a notice of the successor Trustee's
succession to the Holders. The retiring Trustee shall promptly transfer all
property held by it as Trustee to the successor Trustee. Notwithstanding
replacement of the Trustee pursuant to this Section 5.9, the Company's
obligations under Section 5.8 hereof shall continue for the benefit of the
retiring Trustee with respect to expenses, losses and liabilities incurred by it
prior to such replacement.

         SECTION 5.10 SUCCESSOR TRUSTEE BY MERGER, ETC.

         Subject to Section 5.11 hereof, if the Trustee consolidates with,
merges or converts into, or transfers or sells all or substantially all of its
corporate trust business to, another corporation or national banking
association, the successor entity without any further act shall be the successor
Trustee as to the Securities.

         SECTION 5.11 CORPORATE TRUSTEE REQUIRED; ELIGIBILITY.

         The Trustee shall at all times satisfy the requirements of Section
310(a)(1), (2) and (5) of the TIA. The Trustee shall at all times have (or, in
the case of a corporation included in a bank holding company system, the related
bank holding company shall at all times have), a combined capital and surplus of
at least $100 million as set forth in its (or its related bank holding
company's) most recent published annual report of condition. The Trustee is
subject to Section 310(b) of the TIA.

         SECTION 5.12 COLLECTION OF CLAIMS AGAINST THE COMPANY.

         The Trustee is subject to Section 311(a) of the TIA, excluding any
creditor relationship listed in Section 311(b) of the TIA. A Trustee who has
resigned or been removed shall be subject to Section 311(a) of the TIA to the
extent indicated therein.



                                       45
<PAGE>


                                    ARTICLE 6

              CONSOLIDATION, MERGER, CONVEYANCE, TRANSFER OR LEASE

         SECTION 6.1 COMPANY MAY CONSOLIDATE, ETC., ONLY ON CERTAIN TERMS.

         The Company shall not consolidate with or merge into any other Person
or convey, transfer or lease its properties and assets substantially as an
entirety to any Person, and the Company shall not permit any Person to
consolidate with or merge into the Company or convey, transfer or lease its
properties and assets substantially as an entirety to the Company, unless:

                           (1) in the event that the Company shall consolidate
         with or merge into another Person or convey, transfer or lease its
         properties and assets substantially as an entirety to any Person, the
         Person formed by such consolidation or into which the Company is merged
         or the Person which acquires by conveyance or transfer, or which
         leases, the properties and assets of the Company substantially as an
         entirety shall be a corporation, limited liability company, partnership
         or trust organized and validly existing under the laws of the United
         States of America, any State thereof or the District of Columbia and,
         if the entity surviving such transaction or transferee entity is not
         the Company, then such surviving or transferee entity shall expressly
         assume, by an indenture supplemental hereto, executed and delivered to
         the Trustee, in form satisfactory to the Trustee, the due and punctual
         payment of the principal of and premium, if any and interest (including
         Liquidated Damages, if any), on all the Securities and the performance
         of every covenant of this Indenture on the party of the Company to be
         performed or observed and shall have provided for conversion rights in
         accordance with Section 12.11 hereof;

                           (2) at the time of consummation of such transaction,
         no Event of Default, and no event which, after notice or lapse of time
         or both, would become an Event of Default, shall have happened and be
         continuing; and

                           (3) the Company shall have delivered to the Trustee
         an Officers' Certificate and an Opinion of Counsel, each stating that
         such consolidation, merger, conveyance, transfer or lease and, if a
         supplemental indenture is required in connection with such transaction,
         such supplemental indenture comply with this Article and that all
         conditions precedent herein provided for relating to such transaction
         have been complied with.

         SECTION 6.2 SUCCESSOR CORPORATION SUBSTITUTED.

         Upon any consolidation or merger by the Company with or into any other
corporation or any conveyance, transfer or lease of the properties and assets of
the Company substantially as an entirety to any Person, in accordance with
Section 6.1 hereof, the successor corporation formed by such consolidation or
into which the Company is merged or to which such conveyance, transfer or lease
is made shall succeed to, and be substituted for, and may exercise every right
and power of, the Company under this Indenture with the same effect as if such
successor



                                       46
<PAGE>


corporation had been named as the Company herein, and thereafter, except in the
case of a lease to another Person, the predecessor corporation shall be relieved
of all obligations and covenants under this Indenture and the Securities.



                                       47
<PAGE>


                                    ARTICLE 7

                       AMENDMENTS, SUPPLEMENTS AND WAIVERS

         SECTION 7.1 WITHOUT CONSENT OF HOLDERS OF SECURITIES.

         Without the consent of any Holders of Securities, the Company, when
authorized by a Board Resolution, and the Trustee, at any time and from time to
time, may amend this Indenture and the Securities to:

         (a) add to the covenants of the Company for the benefit of the Holders
of Securities;

         (b) surrender any right or power herein conferred upon the Company;

         (c) make provision with respect to the conversion rights of Holders of
Securities pursuant to Section 12.11 hereof;

         (d) provide for the assumption of the Company's obligations to the
Holders of Securities in the case of a merger, consolidation, conveyance,
transfer or lease pursuant to Article 6 hereof;

         (e) reduce the Conversion Price; provided, that such reduction in the
Conversion Price shall not adversely affect the interest of the Holders of
Securities (after taking into account tax and other consequences of such
reduction) in any material respect;

         (f) comply with the requirements of the SEC in order to effect or
maintain the qualification of this Indenture under the TIA;

         (g) make any changes or modifications to this Indenture necessary in
connection with the registration of any Securities under the Securities Act as
contemplated in the Registration Rights Agreement, provided, that such action
pursuant to this clause (g) does not adversely affect the interests of the
Holders of Securities in any material respect;

         (h) cure any ambiguity, to correct or supplement any provision herein
which may be inconsistent with any other provision herein or which is otherwise
defective, or to make any other provisions with respect to matters or questions
arising under this Indenture which the Company and the Trustee may deem
necessary or desirable and which shall not be inconsistent with the provisions
of this Indenture, provided, that such action pursuant to this clause (h) does
not adversely affect the interests of the Holders of Securities in any material
respect;

         (i) add or modify any other provisions with respect to matters or
questions arising under this Indenture which the Company and the Trustee may
deem necessary or desirable and which shall not be inconsistent with the
provisions of this Indenture, provided, that such action pursuant to this clause
(i) does not adversely affect the interests of the Holders of Securities in any
material respect; or



                                       48
<PAGE>


         (j) make provision for the establishment of a book-entry system, in
which Holders would have the option to participate, for the clearance and
settlement of transactions in Securities originally issued in definitive form.

         SECTION 7.2 WITH CONSENT OF HOLDERS OF SECURITIES.

         Except as provided below in this Section 7.2, this Indenture or the
Securities may be amended or supplemented, and noncompliance in any particular
instance with any provision of this Indenture or the Securities may be waived,
in each case (i) with the written consent of the Holders of at least a majority
in aggregate principal amount of the Outstanding Securities or (ii) by the
adoption of a resolution, at a meeting of Holders of the Outstanding Securities
at which a quorum is present, by the Holders of a majority in aggregate
principal amount of the Outstanding Securities represented at such meeting.

         Without the written consent or the affirmative vote of each Holder of
Securities, an amendment or waiver under this Section 7.2 may not:

         (a) change the Stated Maturity of the principal of, or any installment
of interest (including Liquidated Damages, if any) on, any Security;

         (b) reduce the principal amount of, or premium, if any, on any
Security;

         (c) reduce the Interest Rate or interest (including Liquidated Damages,
if any) on any Security;

         (d) change the currency of payment of principal of, premium, if any, or
interest (including Liquidated Damages, if any) on any Security;

         (e) impair the right of any Holder to institute suit for the
enforcement of any payment in or with respect to any Security;

         (f) modify the obligation of the Company to maintain an office or
agency in The City of New York pursuant to Section 9.2 hereof;

         (g) except as permitted by Section 12.11 hereof, adversely affect the
Repurchase Right or the right to convert any Security as provided in Article 12
hereof;

         (h) modify the subordination provisions of the Securities in a manner
adverse to the Holders of Securities,

         (i) modify any of the provisions of this Section, Section 4.4 or
Section 14.11, except to increase any percentage contained herein or therein or
to provide that certain other provisions of this Indenture cannot be modified or
waived without the consent of the Holder of each Outstanding Security affected
thereby; or

         (j) reduce the requirements of Section 8.4 hereof for quorum or voting,
or reduce the percentage in aggregate principal amount of the Outstanding
Securities the consent of whose



                                       49
<PAGE>


Holders is required for any such supplemental indenture or the consent of whose
Holders is required for any waiver provided for in this Indenture.

         It shall not be necessary for any Act of Holders of Securities under
this Section to approve the particular form of any proposal supplemental
indenture, but it shall be sufficient if such Act shall approve the substance
thereof.

         SECTION 7.3 COMPLIANCE WITH TRUST INDENTURE ACT.

         Every amendment to this Indenture or the Securities shall be set forth
in a supplemental indenture that complies with the TIA as then in effect.

         SECTION 7.4 REVOCATION OF CONSENTS AND EFFECT OF CONSENTS OR VOTES.

         Until an amendment, supplement or waiver becomes effective, a written
consent to it by a Holder is a continuing consent by the Holder and every
subsequent Holder of a Security or portion of a Security that evidences the same
debt as the consenting Holder's Security, even if notation of the consent is not
made on any Security; provided, however, that unless a record date shall have
been established, any such Holder or subsequent Holder may revoke the consent as
to its Security or portion of a Security if the Trustee receives written notice
of revocation before the date the amendment, supplement or waiver becomes
effective.

         An amendment, supplement or waiver becomes effective on receipt by the
Trustee of written consents from or affirmative votes by, as the case may be,
the Holders of the requisite percentage of aggregate principal amount of the
Outstanding Securities, and thereafter shall bind every Holder of Securities;
provided, however, if the amendment, supplement or waiver makes a change
described in any of the clauses (a) through (j) of Section 7.2 hereof, the
amendment, supplement or waiver shall bind only each Holder of a Security which
has consented to it or voted for it, as the case may be, and every subsequent
Holder of a Security or portion of a Security that evidences the same
indebtedness as the Security of the consenting or affirmatively voting, as the
case may be, Holder.

         SECTION 7.5 NOTATION ON OR EXCHANGE OF SECURITIES.

         If an amendment, supplement or waiver changes the terms of a Security:

         (a) the Trustee may require the Holder of a Security to deliver such
Securities to the Trustee, the Trustee may place an appropriate notation on the
Security about the changed terms and return it to the Holder and the Trustee may
place an appropriate notation on any Security thereafter authenticated; or

         (b) if the Company or the Trustee so determines, the Company in
exchange for the Security shall issue and the Trustee shall authenticate a new
Security that reflects the changed terms.



                                       50
<PAGE>


         Failure to make the appropriate notation or issue a new Security shall
not affect the validity and effect of such amendment, supplement or waiver.

         SECTION 7.6 TRUSTEE TO SIGN AMENDMENT, ETC.

         The Trustee shall sign any amendment authorized pursuant to this
Article 7 if the amendment does not adversely affect the rights, duties,
liabilities or immunities of the Trustee. If the amendment does adversely affect
the rights, duties, liabilities or immunities of the Trustee, the Trustee may
but need not sign it. In signing or refusing to sign such amendment, the Trustee
shall be entitled to receive and shall be fully protected in relying upon an
Officers' Certificate and an Opinion of Counsel as conclusive evidence that such
amendment is authorized or permitted by this Indenture.



                                       51
<PAGE>


                                    ARTICLE 8

                        MEETING OF HOLDERS OF SECURITIES

         SECTION 8.1 PURPOSES FOR WHICH MEETINGS MAY BE CALLED.

         A meeting of Holders of Securities may be called at any time and from
time to time pursuant to this Article to make, give or take any request, demand,
authorization, direction, notice, consent, waiver or other action provided by
this Indenture to be made, given or taken by Holders of Securities.

         SECTION 8.2 CALL NOTICE AND PLACE OF MEETINGS.

         (a) The Trustee may at any time call a meeting of Holders of Securities
for any purpose specified in Section 8.1 hereof, to be held at such time and at
such place in The City of New York. Notice of every meeting of Holders of
Securities, setting forth the time and the place of such meeting and in general
terms the action proposed to be taken at such meeting, shall be given, in the
manner provided in Section 14.2 hereof, not less than 21 nor more than 180 days
prior to the date fixed for the meeting.

         (b) In case at any time the Company, pursuant to a Board Resolution, or
the Holders of at least 10% in principal amount of the Outstanding Securities
shall have requested the Trustee to call a meeting of the Holders of Securities
for any purpose specified in Section 8.1 hereof, by written request setting
forth in reasonable detail the action proposed to be taken at the meeting, and
the Trustee shall not have made the first publication of the notice of such
meeting within 21 days after receipt of such request or shall not thereafter
proceed to cause the meeting to be held as provided herein, then the Company or
the Holders of Securities in the amount specified, as the case may be, may
determine the time and the place in The City of New York for such meeting and
may call such meeting for such purposes by giving notice thereof as provided in
paragraph (a) of this Section.

         SECTION 8.3 PERSONS ENTITLED TO VOTE AT MEETINGS.

         To be entitled to vote at any meeting of Holders of Securities, a
Person shall be (a) a Holder of one or more Outstanding Securities, or (b) a
Person appointed by an instrument in writing as proxy for a Holder or Holders of
one or more Outstanding Securities by such Holder or Holders. The only Persons
who shall be entitled to be present or to speak at any meeting of Holders shall
be the Persons entitled to vote at such meeting and their counsel, any
representatives of the Trustee and its counsel and any representatives of the
Company and its counsel.

         SECTION 8.4 QUORUM; ACTION.

         The Persons entitled to vote a majority in principal amount of the
Outstanding Securities shall constitute a quorum. In the absence of a quorum
within 30 minutes of the time appointed for any such meeting, the meeting shall,
if convened at the request of Holders of Securities, be



                                       52
<PAGE>


dissolved. In any other case, the meeting may be adjourned for a period of not
less than 10 days as determined by the chairman of the meeting prior to the
adjournment of such meeting. In the absence of a quorum at any such adjourned
meeting, such adjourned meeting may be further adjourned for a period of not
less than 10 days as determined by the chairman of the meeting prior to the
adjournment of such adjourned meeting. Notice of the reconvening of any
adjourned meeting shall be given as provided in Section 8.2(a) hereof, except
that such notice need be given only once and not less than five days prior to
the date on which the meeting is scheduled to be reconvened. Notice of the
reconvening of an adjourned meeting shall state expressly the percentage of the
principal amount of the Outstanding Securities which shall constitute a quorum.

         Subject to the foregoing, at the reconvening of any meeting adjourned
for a lack of a quorum, the Persons entitled to vote 25% in principal amount of
the Outstanding Securities at the time shall constitute a quorum for the taking
of any action set forth in the notice of the original meeting.

         At a meeting or an adjourned meeting duly reconvened and at which a
quorum is present as aforesaid, any resolution and all matters (except as
limited by the proviso to Section 7.2 hereof) shall be effectively passed and
decided if passed or decided by the Persons entitled to vote not less than a
majority in principal amount of Outstanding Securities represented and voting at
such meeting.

         Any resolution passed or decisions taken at any meeting of Holders of
Securities duly held in accordance with this Section shall be binding on all the
Holders of Securities, whether or not present or represented at the meeting.

         SECTION 8.5 DETERMINATION OF VOTING RIGHTS; CONDUCT AND ADJOURNMENT OF
                     MEETINGS.

         (a) Notwithstanding any other provisions of this Indenture, the Trustee
may make such reasonable regulations as it may deem advisable for any meeting of
Holders of Securities in regard to proof of the holding of Securities and of the
appointment of proxies and in regard to the appointment and duties of inspectors
of votes, the submission and examination of proxies, certificates and other
evidence of the right to vote, and such other matters concerning the conduct of
the meeting as it shall deem appropriate. Except as otherwise permitted or
required by any such regulations, the holding of Securities shall be proved in
the manner specified in Section 1.3 hereof and the appointment of any proxy
shall be proved in the manner specified in Section 1.3 hereof. Such regulations
may provide that written instruments appointing proxies, regular on their face,
may be presumed valid and genuine without the proof specified in Section 1.3
hereof or other proof.

         (b) The Trustee shall, by an instrument in writing, appoint a temporary
chairman (which may be the Trustee) of the meeting, unless the meeting shall
have been called by the Company or by Holders of Securities as provided in
Section 8.2(b) hereof, in which case the Company or the Holders of Securities
calling the meeting, as the case may be, shall in like manner appoint a
temporary chairman. A permanent chairman and a permanent secretary of the



                                       53
<PAGE>


meeting shall be elected by vote of the Persons entitled to vote a majority in
principal amount of the Outstanding Securities represented at the meeting.

         (c) At any meeting each Holder of a Security or proxy shall be entitled
to one vote for each $1,000 principal amount of Securities held or represented
by him; provided, however, that no vote shall be cast or counted at any meeting
in respect of any Security challenged as not Outstanding and ruled by the
chairman of the meeting to be not Outstanding. The chairman of the meeting shall
have no right to vote, except as a Holder of a Security or proxy.

         (d) Any meeting of Holders of Securities duly called pursuant to
Section 8.2 hereof at which a quorum is present may be adjourned from time to
time by Persons entitled to vote a majority in principal amount of the
Outstanding Securities represented at the meeting, and the meeting may be held
as so adjourned without further notice.

         SECTION 8.6 COUNTING VOTES AND RECORDING ACTION OF MEETINGS.

         The vote upon any resolution submitted to any meeting of Holders of
Securities shall be by written ballots on which shall be subscribed the
signatures of the Holders of Securities or of their representatives by proxy and
the principal amounts and serial numbers of the Outstanding Securities held or
represented by them. The permanent chairman of the meeting shall appoint two
inspectors of votes who shall count all votes cast at the meeting for or against
any resolution and who shall make and file with the secretary of the meeting
their verified written reports in duplicate of all votes cast at the meeting. A
record, at least in duplicate, of the proceedings of each meeting of Holders of
Securities shall be prepared by the secretary of the meeting and there shall be
attached to said record the original reports of the inspectors of votes on any
vote by ballot taken thereat and affidavits by one or more Persons having
knowledge of the facts setting forth a copy of the notice of the meeting and
showing that said notice was given as provided in Section 8.2 hereof and, if
applicable, Section 8.4 hereof. Each copy shall be signed and verified by the
affidavits of the permanent chairman and secretary of the meeting and one such
copy shall be delivered to the Company and another to the Trustee to be
preserved by the Trustee, the latter to have attached thereto the ballots voted
at the meeting. Any record so signed and verified shall be conclusive evidence
of the matters therein stated.



                                       54

<PAGE>


                                    ARTICLE 9

                                    COVENANTS

         SECTION 9.1 PAYMENT OF PRINCIPAL, PREMIUM AND INTEREST.

         The Company will duly and punctually pay the principal of and premium,
if any, and interest (including Liquidated Damages, if any) in respect of the
Securities in accordance with the terms of the Securities and this Indenture.
The Company will deposit or cause to be deposited with the Trustee as directed
by the Trustee, no later than the day of the Stated Maturity of any Security or
installment of interest (including Liquidated Damages, if any), all payments so
due.

         SECTION 9.2 MAINTENANCE OF OFFICES OR AGENCIES.

         The Company hereby appoints the Trustee's Corporate Trust Office as its
office in The City of New York, where Securities may be:

                           (i) presented or surrendered for payment;

                           (ii) surrendered for registration of transfer or
         exchange;

                           (iii)    surrendered for conversion;

and where notices and demands to or upon the Company in respect of the
Securities and this Indenture maybe served.

         The Company may at any time and from time to time vary or terminate the
appointment of any such office or appoint any additional offices for any or all
of such purposes; provided, however, that until all of the Securities have been
delivered to the Trustee for cancellation, or moneys sufficient to pay the
principal of and premium, if any, and interest (including Liquidated Damages, if
any) on the Securities have been made available for payment and either paid or
returned to the Company pursuant to the provisions of Section 9.3 hereof, the
Company will maintain in The City of New York, an office or agency where
Securities may be presented or surrendered for payment, where Securities may be
surrendered for registration of transfer or exchange, where Securities may be
surrendered for conversion and where notices and demands to or upon the Company
in respect of the Securities and this Indenture may be served. The Company will
give prompt written notice to the Trustee, and notice to the Holders in
accordance with Section 14.2 hereof, of the appointment or termination of any
such agents and of the location and any change in the location of any such
office or agency.

         If at any time the Company shall fail to maintain any such required
office or agency in The City of New York, or shall fail to furnish the Trustee
with the address thereof, presentations and surrenders may be made at, and
notices and demands may be served on, the Corporate Trust Office of the Trustee.



                                       55
<PAGE>


         SECTION 9.3 CORPORATE EXISTENCE.

         Subject to Article 6 hereof, the Company will do or cause to be done
all things necessary to preserve and keep in full force and effect its corporate
existence, rights (charter and statutory) and franchises; provided, however,
that the Company shall not be required to preserve any such right or franchise
if the Company determines that the preservation thereof is no longer desirable
in the conduct of the business of the Company and that the loss thereof is not
disadvantageous in any material respect to the Holders.

         SECTION 9.4 MAINTENANCE OF PROPERTIES.

         The Company will maintain and keep its properties and every part
thereof in such repair, working order and condition, and make or cause to be
made all such needful and proper repairs, renewals and replacements thereto, as
in the judgment of the Company are necessary in the interests of the Company;
provided, however, that nothing contained in this Section shall prevent the
Company from selling, abandoning or otherwise disposing of any of its properties
or discontinuing a part of its business from time to time if, in the judgment of
the Company, such sale, abandonment, disposition or discontinuance is advisable
and does not materially adversely affect the interests or business of the
Company.

         SECTION 9.5 PAYMENT OF TAXES AND OTHER CLAIMS.

         The Company will, and will cause any Significant Subsidiary to,
promptly pay and discharge or cause to be paid and discharged all material
taxes, assessments and governmental charges or levies lawfully imposed upon it
or upon its income or profits or upon any of its property, real or personal, or
upon any part thereof, as well as all material claims for labor, materials and
supplies which, if unpaid, might by law become a lien or charge upon its
property; provided, however, that neither the Company nor any Significant
Subsidiary shall be required to pay or discharge or cause to be paid or
discharged any such tax, assessment, charge, levy, or claim if the amount,
applicability or validity thereof shall currently be contested in good faith by
appropriate proceedings and if the Company or such Significant Subsidiary, as
the case may be, shall have set aside on its books reserves deemed by it
adequate with respect thereto.

         SECTION 9.6 REPORTS.

         (a) The Company shall deliver to the Trustee within 15 days after it
files them with the SEC copies of the annual reports and of the information,
documents, and other reports (or copies of such portions of any of the foregoing
as the SEC may by rules and regulations prescribe) which the Company is required
to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act;
provided, however, the Company shall not be required to deliver to the Trustee
any materials for which the Company has sought and received confidential
treatment by the SEC. The Company also shall comply with the other provisions of
Section 314(a) of the TIA.

         (b) If at any time the Company is not subject to Section 13 or 15(d) of
the Exchange Act, upon the request of a Holder of a Security, the Company will
promptly furnish or cause to



                                       56
<PAGE>


be furnished to such Holder or to a prospective purchaser of such Security
designated by such Holder, as the case may be, the information, if any, required
to be delivered by it pursuant to Rule 144A(d)(4) under the Securities Act to
permit compliance with Rule 144A in connection with the resale of such Security;
provided, however, that the Company shall not be required to furnish such
information in connection with any request made on or after the date which is
two years from the later of the date such security was last acquired from the
Company or an "affiliate" of the Company.

         SECTION 9.7 COMPLIANCE CERTIFICATE.

         The Company shall deliver to the Trustee, within 120 days after the end
of each fiscal year of the Company, an Officers' Certificate stating that in the
course of the performance by the signers of their duties as Officers of the
Company, they would normally have knowledge of any failure by the Company to
comply with all conditions, or Default by the Company with respect to any
covenants, under this Indenture, and further stating whether or not they have
knowledge of any such failure or default and, if so, specifying each such
failure or Default and the nature thereof. In the event an Officer of the
Company comes to have actual knowledge of a Default, regardless of the date, the
Company shall deliver an Officers' Certificate to the Trustee specifying such
Default and the nature and status thereof.

         SECTION 9.8 RESALE OF CERTAIN SECURITIES.

         During the period of two years after the last date of original issuance
of any Securities, the Company shall not, and shall not permit any of its
"affiliates" (as defined under Rule 144 under the Securities Act) to, resell any
Securities, or shares of Common Stock issuable upon conversion of the
Securities, which constitute "restricted securities" under Rule 144, that are
acquired by any of them within the United States or to "U.S. persons" (as
defined in Regulation S) except pursuant to an effective registration statement
under the Securities Act or an applicable exemption therefrom. The Trustee shall
have no responsibility or liability in respect of the Company's performance of
its agreement in the preceding sentence.



                                       57
<PAGE>


                                   ARTICLE 10

                            REDEMPTION OF SECURITIES

         SECTION 10.1 PROVISIONAL REDEMPTION.

         Any time prior to February 8, 2003, the Company may, at its option,
redeem the Securities in whole or in part on any date from time to time, upon
notice as set forth in Section 10.5, at a redemption price equal to $1,000 per
$1,000 principal amount of the Securities redeemed plus accrued and unpaid
interest, if any (such amount, together with the Make-Whole Payment described
below, the "Provisional Redemption Price"), to but excluding the date of
redemption (the "Provisional Redemption Date") if (i) the Closing Price of the
Common Stock has exceeded 150% of the Conversion Price (as defined in Article 12
and as such may be adjusted from time to time) then in effect for at least 20
Trading Days in any consecutive 30-Trading Day period ending on the Trading Day
prior to the date of mailing of the provisional notice of redemption pursuant to
Section 10.5 (the "Notice Date"), and (ii) a registration statement covering
resales of the Securities and the Common Stock issuable upon conversion thereof
is effective and available for use and is expected to remain effective for the
30 days following the Provisional Redemption Date.

         Upon any such Provisional Redemption, the Company shall make an
additional payment in cash (the "Make-Whole Payment") with respect to the
Securities called for redemption to holders on the Notice Date in an amount
equal to $137.93 per $1,000 principal amount of the Securities, less the amount
of any interest actually paid on such Securities prior to the Notice Date. The
Company shall make the Make-Whole Payment on all Securities called for
Provisional Redemption, including those Securities converted into Common Stock
between the Notice Date and the Provisional Redemption Date.

         SECTION 10.2 OPTIONAL REDEMPTION.

         Except as set forth under Section 10.1, the Securities are not
redeemable prior to February 8, 2003. On or after February 8 , 2003, the Company
may, at its option, redeem the Securities in whole at any time or in part from
time to time, on any date prior to maturity, upon notice as set forth in Section
10.5, at the redemption price (expressed as percentages of the principal amount)
set forth below if redeemed during the 12-month period beginning February 8 of
the years indicated and ending February 7 of the following year:

<TABLE>
<CAPTION>

                                                                                 Redemption Price
                                                                                 ----------------
<S>               <C>                                                                     <C>
                  2003.................................................                   102.90%

                  2004.................................................                   102.10%

                  2005.................................................                   101.40%

                  2006.................................................                   100.70%
</TABLE>



                                       58
<PAGE>


("the Optional Redemption Price"), plus any interest accrued but not paid prior
to the Optional Redemption Date.

         SECTION 10.3 NOTICE TO TRUSTEE.

         If the Company elects to redeem Securities pursuant to the redemption
provisions of Section 10.1 or Section 10.2 hereof, it shall notify the Trustee
at least 30 days prior to the Redemption Date of such intended Redemption Date,
the principal amount of Securities to be redeemed and the CUSIP numbers of the
Securities to be redeemed.

         SECTION 10.4 SELECTION OF SECURITIES TO BE REDEEMED.

         If fewer than all the Securities are to be redeemed, the Trustee shall
select the particular Securities to be redeemed from the Outstanding Securities
by a method that complies with the requirements of any exchange on which the
Securities are listed, or, if the Securities are not listed on an exchange, on a
pro rata basis or by lot or in accordance with any other method the Trustee
considers fair and appropriate. Securities and portions thereof that the Trustee
selects shall be in amounts equal to the minimum authorized denominations for
Securities to be redeemed or any integral multiple thereof.

         If any Security selected for partial redemption is converted in part
before termination of the conversion right with respect to the portion of the
Security so selected, the converted portion of such Security shall be deemed to
be the portion selected for redemption (provided, however, that the Holder of
such Security so converted and deemed redeemed shall not be entitled to any
additional interest payment as a result of such deemed redemption than such
Holder would have otherwise been entitled to receive upon conversion of such
Security). Securities which have been converted during a selection of Securities
to be redeemed may be treated by the Trustee as Outstanding for the purpose of
such selection.

         The Trustee shall promptly notify the Company and the Registrar in
writing of the Securities selected for redemption and, in the case of any
Securities selected for partial redemption, the principal amount thereof to be
redeemed.

         For all purposes of this Indenture, unless the context otherwise
requires, all provisions relating to the redemption of Securities shall relate,
in the case of any Securities redeemed or to be redeemed only in part, to the
portion of the principal amount of such Securities which has been or is to be
redeemed.

         SECTION 10.5 NOTICE OF REDEMPTION.

         Notice of redemption shall be given in the manner provided in Section
14.2 hereof to the Holders of Securities to be redeemed. Such notice shall be
given not less than 20 nor more than 60 days prior to the Redemption Date.

         All notices of redemption shall state:



                                       59
<PAGE>


                           (1) the Redemption Date;

                           (2) the Redemption Price and interest accrued and
        unpaid to the Redemption Date, if any;

                           (3) if fewer than all the Outstanding Securities are
        to be redeemed, the aggregate principal amount of Securities to be
        redeemed and the aggregate principal amount of Securities which will be
        outstanding after such partial redemption;

                           (4) that on the Redemption Date the Redemption Price
        and interest accrued and unpaid to the Redemption Date, if any, will
        become due and payable upon each such Security to be redeemed, and that
        interest thereon shall cease to accrue on and after such date;

                           (5) the Conversion Price, the date on which the right
        to convert the principal of the Securities to be redeemed will terminate
        and the places where such Securities may be surrendered for conversion;

                           (6) the place or places where such Securities are to
        be surrendered for payment of the Redemption Price and accrued and
        unpaid interest, if any; and

                           (7) the CUSIP number of the Securities.

         The notice given shall specify the last date on which exchanges or
transfers of Securities may be made pursuant to Section 2.7 hereof, and shall
specify the serial numbers of Securities and the portions thereof called for
redemption.

         Notice of redemption of Securities to be redeemed at the election of
the Company shall be given by the Company or, at the Company's request, by the
Trustee in the name of and at the expense of the Company.

         SECTION 10.6 EFFECT OF NOTICE OF REDEMPTION.

         Notice of redemption having been given as provided in Section 10.5
hereof, the Securities so to be redeemed shall, on the Redemption Date, become
due and payable at the Redemption Price therein specified and from and after
such date (unless the Company shall default in the payment of the Redemption
Price and accrued and unpaid interest) such Securities shall cease to bear
interest. Upon surrender of any such Security for redemption in accordance with
such notice, such Security shall be paid by the Company at the Redemption Price;
provided, however, the installments of interest on Securities whose Stated
Maturity is prior to or on the Redemption Date shall be payable to the Holders
of such Securities, or one or more Predecessor Securities, registered as such on
the relevant Record Date according to their terms and the provisions of Section
2.7 hereof.



                                       60
<PAGE>


         If any Security called for redemption shall not be so paid upon
surrender thereof for redemption, the principal and premium, if any, shall,
until paid, bear interest from the Redemption Date at the Interest Rate.

         SECTION 10.7 DEPOSIT OF REDEMPTION PRICE.

         Prior to or on any Redemption Date, the Company shall deposit with the
Trustee or with a Paying Agent an amount of money sufficient to pay the
Redemption Price of all the Securities to be redeemed on that Redemption Date,
other than any Securities called for redemption on that date which have been
converted prior to the date of such deposit, and accrued and unpaid interest, if
any, on such Securities.

         If any Security called for redemption is converted, any money deposited
with the Trustee or with a Paying Agent or so segregated and held in trust for
the redemption of such Security shall (subject to any right of the Holder of
such Security or any Predecessor Security to receive interest as provided in the
fourth to last paragraph of Section 2.1 hereof) be paid to the Company on
Company Request or, if then held by the Company, shall be discharged from such
trust.

         SECTION 10.8 SECURITIES REDEEMED IN PART.

         Any Security which is to be redeemed only in part shall be surrendered
at an office or agency of the Company designated for that purpose pursuant to
Section 9.2 hereof (with, if the Company or the Trustee so requires, due
endorsement by, or a written instrument of transfer in form satisfactory to the
Company and the Trustee duly executed by, the Holder thereof or the Holder's
attorney duly authorized in writing), and the Company shall execute, and the
Trustee shall authenticate and deliver to the Holder of such Security without
service charge, a new Security or Securities of any authorized denomination as
requested by such Holder in aggregate principal amount equal to and in exchange
for the unredeemed portion of the principal of the Security so surrendered.



                                       61
<PAGE>


                                   ARTICLE 11

                      REPURCHASE AT THE OPTION OF A HOLDER
                            UPON A CHANGE OF CONTROL

         SECTION 11.1 REPURCHASE RIGHT.

         In the event that a Change in Control shall occur, each Holder shall
have the right (the "Repurchase Right"), at the Holder's option, but subject to
the provisions of Section 11.2 hereof, to require the Company to repurchase, and
upon the exercise of such right the Company shall repurchase, all of such
Holder's Securities not theretofore called for redemption, or any portion of the
principal amount thereof that is equal to $1,000 or any integral multiple
thereof (provided that no single Security may be repurchased in part unless the
portion of the principal amount of such Security to be Outstanding after such
repurchase is equal to $1,000 or integral multiples thereof), on the date (the
"Repurchase Date") that is 45 days after the date of the Company Notice at a
purchase price equal to 100% of the principal amount of the Securities to be
repurchased (the "Repurchase Price"), plus interest accrued and unpaid to, but
excluding, the Repurchase Date; provided, however, that installments of interest
on Securities whose Stated Maturity is prior to or on the Repurchase Date shall
be payable to the Holders of such Securities, or one or more Predecessor
Securities, registered as such on the relevant Record Date according to their
terms and the provisions of Section 2.1 hereof.

         Subject to the fulfillment by the Company of the conditions set forth
in Section 11.2 hereof, the Company may elect to pay the Repurchase Price by
delivering the number of shares of Common Stock equal to (i) the Repurchase
Price divided by (ii) 95% of the average of the Closing Prices per share of
Common Stock for the five consecutive Trading Days immediately preceding and
including the third Trading Day prior to the Repurchase Date.

         Whenever in this Indenture (including Sections 2.2, 4.1(a) and 4.7
hereof) or Exhibit A annexed hereto there is a reference, in any context, to the
principal of any Security as of any time, such reference shall be deemed to
include reference to the Repurchase Price payable in respect to such Security to
the extent that such Repurchase Price is, was or would be so payable at such
time, and express mention of the Repurchase Price in any provision of this
Indenture shall not be construed as excluding the Repurchase Price in those
provisions of this Indenture when such express mention is not made; provided,
however, that, for the purposes of Article 13 hereof, such reference shall be
deemed to include reference to the Repurchase Price only to the extent the
Repurchase Price is payable in cash.

         SECTION 11.2 CONDITIONS TO THE COMPANY'S ELECTION TO PAY THE REPURCHASE
                      PRICE IN COMMON STOCK.

         (a) The shares of Common Stock to be issued upon repurchase of
Securities hereunder:

                     (i) shall not require registration under any federal
         securities law before such shares may be freely transferable without
         being subject to any transfer restrictions under



                                       62
<PAGE>


         the Securities Act upon repurchase or, if such registration is
         required, such registration shall be completed and shall become
         effective prior to the Repurchase Date; and

                     (ii) shall not require registration with, or approval of,
         any governmental authority under any state law or any other federal law
         before shares may be validly issued or delivered upon repurchase or if
         such registration is required or such approval must be obtained, such
         registration shall be completed or such approval shall be obtained
         prior to the Repurchase Date.

         (b) The shares of Common Stock to be listed upon repurchase of
Securities hereunder are, or shall have been, approved for listing on the Nasdaq
National Market or the New York Stock Exchange or listed on another national
securities exchange, in any case, prior to the Repurchase Date.

         (c) All shares of Common Stock which may be issued upon repurchase of
Securities will be issued out of the Company's authorized but unissued Common
Stock and will, upon issue, be duly and validly issued and fully paid and
nonassessable and free of any preemptive or similar rights.

         (d) If any of the conditions set forth in clauses (a) through (d) of
this Section 11.2 are not satisfied in accordance with the terms thereof, the
Repurchase Price shall be paid by the Company only in cash.

         SECTION 11.3 NOTICES; METHOD OF EXERCISING REPURCHASE RIGHT, ETC.

         (a) Unless the Company shall have theretofore called for redemption all
of the Outstanding Securities, prior to or on the 30th day after the occurrence
of a Change in Control, the Company, or, at the written request and expense of
the Company prior to or on the 30th day after such occurrence, the Trustee,
shall give to all Holders of Securities notice, in the manner provided in
Section 14.2 hereof, of the occurrence of the Change of Control and of the
Repurchase Right set forth herein arising as a result thereof (the "Company
Notice"). The Company shall also deliver a copy of such notice of a Repurchase
Right to the Trustee. Each notice of a Repurchase Right shall state:

                           (1) the Repurchase Date;

                           (2) the date by which the Repurchase Right must
         exercised;

                           (3) the Repurchase Price and accrued and unpaid
         interest, if any, and whether the Repurchase Price shall be paid by the
         Company in cash or by delivery of shares of Common Stock;

                           (4) a description of the procedure which a Holder
         must follow to exercise a Repurchase Right, and the place or places
         where such Securities, are to be surrendered for payment of the
         Repurchase Price and accrued and unpaid interest, if any;



                                       63
<PAGE>


                           (5) that on the Repurchase Date the Repurchase Price
         and accrued and unpaid interest, if any, will become due and payable
         upon each such Security designated by the Holder to be repurchased, and
         that interest thereon shall cease to accrue on and after said date;

                           (6) the Conversion Rate then in effect, the date on
         which the right to convert the principal amount of the Securities to be
         repurchased will terminate and the place where such Securities may be
         surrendered for conversion, and

                           (7) the place or places where such Securities,
         together with the Option to Elect Repayment Upon a Change of Control
         certificate included in Exhibit A annexed hereto are to be delivered
         for payment of the Repurchase Price and accrued and unpaid interest, if
         any.

         No failure of the Company to give the foregoing notices or defect
therein shall limit any Holder's right to exercise a Repurchase Right or affect
the validity of the proceedings for the repurchase of Securities.

         If any of the foregoing provisions or other provisions of this Article
11 are inconsistent with applicable law, such law shall govern.

         (b) To exercise a Repurchase Right, a Holder shall deliver to the
Trustee prior to or on the 30th day after the date of the Company Notice:

                           (1) written notice of the Holder's exercise of such
                  right, which notice shall set forth the name of the Holder,
                  the principal amount of the Securities to be repurchased (and,
                  if any Security is to be repurchased in part, the serial
                  number thereof, the portion of the principal amount thereof to
                  be repurchased) and a statement that an election to exercise
                  the Repurchase Right is being made thereby, and, in the event
                  that the Repurchase Price shall be paid in shares of Common
                  Stock, the name or names (with addresses) in which the
                  certificate or certificates for shares of Common Stock shall
                  be issued, and

                           (2) the Securities with respect to which the
                  Repurchase Right is being exercised.

Such written notice shall be irrevocable, except that the right of the Holder to
convert the Securities with respect to which the Repurchase Right is being
exercised shall continue until the close of business on the Business Day
immediately preceding the Repurchase Date.

         (c) In the event a Repurchase Right shall be exercised in accordance
with the terms hereof, the Company shall pay or cause to be paid to the Trustee
the Repurchase Price in cash or shares of Common Stock, as provided above, for
payment to the Holder on the Repurchase Date or, if shares of Common Stock are
to be paid, as promptly after the Repurchase Date as practicable, together with
accrued and unpaid interest to the Repurchase Date payable in cash with respect
to the Securities as to which the Repurchase Right has been exercised; provided,



                                       64
<PAGE>


however, that installments of interest that mature prior to or on the Repurchase
Date shall be payable in cash to the Holders of such Securities, or one or more
Predecessor Securities, registered as such at the close of business on the
relevant Regular Record Date.

         (d) If any Security (or portion thereof) surrendered for repurchase
shall not be so paid on the Repurchase Date, the principal amount of such
Security (or portion thereof, as the case may be) shall, until paid, bear
interest to the extent permitted by applicable law from the Repurchase Date at
the Interest Rate, and each Security shall remain convertible into Common Stock
until the principal of such Security (or portion thereof, as the case may be)
shall have been paid or duly provided for.

         (e) Any Security which is to be repurchased only in part shall be
surrendered to the Trustee (with, if the Company or the Trustee so requires, due
endorsement by, or a written instrument of transfer in form satisfactory to the
Company and the Trustee duly executed by the Holder thereof or his attorney duly
authorized in writing), and the Company shall execute, and the Trustee shall
authenticate and make available for delivery to the Holder of such Security
without service charge, a new Security or Securities, containing identical terms
and conditions, each in an authorized denomination in aggregate principal amount
equal to and in exchange for the unrepurchased portion of the principal of the
Security so surrendered.

         (f) Any issuance of shares of Common Stock in respect of the Repurchase
Price shall be deemed to have been effected immediately prior to the close of
business on the Repurchase Date and the Person or Persons in whose name or names
any certificate or certificates for shares of Common Stock shall be issuable
upon such repurchase shall be deemed to have become on the Repurchase Date the
holder or holders of record of the shares represented thereby; provided,
however, that any surrender for repurchase on a date when the stock transfer
books of the Company shall be closed shall constitute the Person or Persons in
whose name or names the certificate or certificates for such shares are to be
issued as the record holder or holders thereof for all purposes at the opening
of business on the next succeeding day on which such stock transfer books are
open. No payment or adjustment shall be made for dividends or distributions on
any Common Stock issued upon repurchase of any Security declared prior to the
Repurchase Date.

         (g) No fractions of shares of Common Stock shall be issued upon
repurchase of any Security or Securities. If more than one Security shall be
repurchased from the same Holder and the Repurchase Price shall be payable in
shares of Common Stock, the number of full shares which shall be issued upon
such repurchase shall be computed on the basis of the aggregate principal amount
of the Securities (or specified portions thereof) to be so repurchased. Instead
of any fractional share of Common Stock which would otherwise be issued on the
repurchase of any Security or Securities (or specified portions thereof), the
Company shall pay a cash adjustment in respect of such fraction (calculated to
the nearest one-100th of a share) in an amount equal to the same fraction of the
Quoted Price of the Common Stock as of the Trading Day preceding the Repurchase
Date.



                                       65
<PAGE>


         (h) Any issuance and delivery of certificates for shares of Common
Stock on repurchase of Securities shall be made without charge to the Holder of
Securities being repurchased for such certificates or for any tax or duty in
respect of the issuance or delivery of such certificates or the Securities
represented thereby; provided, however, that the Company shall not be required
to pay any tax or duty which may be payable in respect of (i) income of the
Holder or (ii) any transfer involved in the issuance or delivery of certificates
for shares of Common Stock in a name other than that of the Holder of the
Securities being repurchased, and no such issuance or delivery shall be made
unless the Persons requesting such issuance or delivery has paid to the Company
the amount of any such tax or duty or has established, to the satisfaction of
the Company, that such tax or duty has been paid.

         (i) All Securities delivered for repurchase shall be delivered to the
Trustee to be canceled at the direction of the Trustee, which shall dispose of
the same as provided in Section 2.15 hereof.



                                       66
<PAGE>


                                   ARTICLE 12

                            CONVERSION OF SECURITIES

         SECTION 12.1 CONVERSION RIGHT AND CONVERSION PRICE.

         Subject to and upon compliance with the provisions of this Article, at
the option of the Holder thereof, any Security or any portion of the principal
amount thereof which is $1,000 or an integral multiple of $1,000 may be
converted at the principal amount thereof, or of such portion thereof, into duly
authorized, fully paid and nonassessable shares of Common Stock, at the
Conversion Price, determined as hereinafter provided, in effect at the time of
conversion. Such conversion right shall expire at the close of business on
February 8, 2007.

         In case a Security or portion thereof is called for redemption, such
conversion right in respect of the Security or the portion so called, shall
expire at the close of business on the second Business Day preceding the
Redemption Date, unless the Company defaults in making the payment due upon
redemption. In the case of a Change of Control for which the Holder exercises
its Repurchase Right with respect to a Security or portion thereof, such
conversion right in respect of the Security or portion thereof shall expire at
the close of business on the Business Day immediately preceding the Repurchase
Date.

         The price at which shares of Common Stock shall be delivered upon
conversion (the "Conversion Price") shall be initially equal to $76.71 per share
of Common Stock. The Conversion Price shall be adjusted in certain instances as
provided in paragraphs (a), (b), (c), (d), (e), (f), (h) and (1) of Section 12.4
hereof.

         SECTION 12.2 EXERCISE OF CONVERSION RIGHT.

         To exercise the conversion right, the Holder of any Security to be
converted shall surrender such Security duly endorsed or assigned to the Company
or in blank, at the office of any Conversion Agent, accompanied by a duly signed
conversion notice substantially in the form attached to the Security to the
Company stating that the Holder elects to convert such Security or, if less than
the entire principal amount thereof is to be converted, the portion thereof to
be converted.

         Securities surrendered for conversion during the period from the close
of business on any Regular Record Date to the opening of business on the next
succeeding Interest Payment Date (except in the case of any Security whose
Maturity is prior to such Interest Payment Date) shall be accompanied by payment
in New York Clearing House funds or other funds acceptable to the Company of an
amount equal to the interest to be received on such Interest Payment Date on the
principal amount of Securities being surrendered for conversion.

         Securities shall be deemed to have been converted immediately prior to
the close of business on the day of surrender of such Securities for conversion
in accordance with the foregoing provisions, and at such time the rights of the
Holders of such Securities as Holders shall cease, and the Person or Persons
entitled to receive the Common Stock issuable


                                       67
<PAGE>


upon conversion shall be treated for all purposes as the record holder or
holders of such Common Stock at such time. As promptly as practicable on or
after the conversion date, the Company shall cause to be issued and delivered
to such Conversion Agent a certificate or certificates for the number of full
shares of Common Stock issuable upon conversion, together with payment in
lieu of any fraction of a share as provided in Section 12.3 hereof.

         In the case of any Security which is converted in part only, upon such
conversion the Company shall execute and the Trustee shall authenticate and
deliver to the Holder thereof, at the expense of the Company, a new Security or
Securities of authorized denominations in aggregate principal amount equal to
the unconverted portion of the principal amount of such Securities.

         If shares of Common Stock to be issued upon conversion of a Restricted
Security, or Securities to be issued upon conversion of a Restricted Security in
part only, are to be registered in a name other than that of the Holder of such
Restricted Security, such Holder must deliver to the Conversion Agent a
certificate in substantially the form set forth in the form of Security set
forth in Exhibit A annexed hereto, dated the date of surrender of such
Restricted Security and signed by such Holder, as to compliance with the
restrictions on transfer applicable to such Restricted Security. Neither the
Trustee nor any Conversion Agent, Registrar or Transfer Agent shall be required
to register in a name other than that of the Holder shares of Common Stock or
Securities issued upon conversion of any such Restricted Security not so
accompanied by a properly completed certificate.

         The Company hereby initially appoints the Trustee as the Conversion
Agent.

         SECTION 12.3 FRACTIONS OF SHARES.

         No fractional shares of Common Stock shall be issued upon conversion of
any Security or Securities. If more than one Security shall be surrendered for
conversion at one time by the same Holder, the number of full shares which shall
be issued upon conversion thereof shall be computed on the basis of the
aggregate principal amount of the Securities (or specified portions thereof) so
surrendered. Instead of any fractional share of Common Stock which would
otherwise be issued upon conversion of any Security or Securities (or specified
portions thereof), the Company shall pay a cash adjustment in respect of such
fraction (calculated to the nearest one-100th of a share) in an amount equal to
the same fraction of the Quoted Price of the Common Stock as of the Trading Day
preceding the date of conversion.

         SECTION 12.4 ADJUSTMENT OF CONVERSION PRICE.

         The Conversion Price shall be subject to adjustments, calculated by the
Company, from time to time as follows:

         (a) In case the Company shall hereafter pay a dividend or make a
distribution to all holders of the outstanding Common Stock in shares of Common
Stock, the Conversion Price in effect at the opening of business on the date
following the date fixed for the determination of stockholders entitled to
receive such dividend or other distribution shall be reduced by multiplying such
Conversion Price by a fraction:



                                       68
<PAGE>


                             (i) the numerator of which shall be the number of
                  shares of Common Stock outstanding at the close of business on
                  the Record Date (as defined in Section 12.4(g)) fixed for such
                  determination, and

                             (ii) the denominator of which shall be the sum of
                  such number of shares and the total number of shares
                  constituting such dividend or other distribution.

Such reduction shall become effective immediately after the opening of business
on the day following the Record Date. If any dividend or distribution of the
type described in this Section 12.4(a) is declared but not so paid or made, the
Conversion Price shall again be adjusted to the Conversion Price which would
then be in effect if such dividend or distribution had not been declared.

         (b) In case the outstanding shares of Common Stock shall be subdivided
into a greater number of shares of Common Stock, the Conversion Price in effect
at the opening of business on the day following the day upon which such
subdivision becomes effective shall be proportionately reduced, and conversely,
in case outstanding shares of Common Stock shall be combined into a smaller
number of shares of Common Stock, the Conversion Price in effect at the opening
of business on the day following the day upon which such combination becomes
effective shall be proportionately increased, such reduction or increase, as the
case may be, to become effective immediately after the opening of business on
the day following the day upon which such subdivision or combination becomes
effective.

         (c) In case the Company shall issue rights or warrants (other than any
rights or warrants referred to in Section 12.4(d)) to all holders of its
outstanding shares of Common Stock entitling them to subscribe for or purchase
shares of Common Stock (or securities convertible into Common Stock) at a price
per share (or having a conversion price per share) less than the Current Market
Price (as defined in Section 12.4(g)) on the Record Date fixed for the
determination of stockholders entitled to receive such rights or warrants, the
Conversion Price shall be adjusted so that the same shall equal the price
determined by multiplying the Conversion Price in effect at the opening of
business on the date after such Record Date by a fraction:

                             (i) the numerator of which shall be the number of
                  shares of Common Stock outstanding at the close of business on
                  the Record Date plus the number of shares which the aggregate
                  offering price of the total number of shares so offered for
                  subscription or purchase (or the aggregate conversion price of
                  the convertible securities so offered) would purchase at such
                  Current Market Price, and

                             (ii) the denominator of which shall be the number
                  of shares of Common Stock outstanding on the close of business
                  on the Record Date plus the total number of additional shares
                  of Common Stock so offered for subscription or purchase (or
                  into which the convertible securities so offered are
                  convertible).

Such adjustment shall become effective immediately after the opening of business
on the day following the Record Date fixed for determination of stockholders
entitled to receive such rights or warrants. To the extent that shares of Common
Stock (or securities convertible into Common



                                       69
<PAGE>


Stock) are not delivered pursuant to such rights or warrants, upon the
expiration or termination of such rights or warrants the Conversion Price shall
be readjusted to the Conversion Price which would then be in effect had the
adjustments made upon the issuance of such rights or warrants been made on the
basis of the delivery of only the number of shares of Common Stock (or
securities convertible into Common Stock) actually delivered. In the event that
such rights or warrants are not so issued, the Conversion Price shall again be
adjusted to be the Conversion Price which would then be in effect if such date
fixed for the determination of stockholders entitled to receive such rights or
warrants had not been fixed. In determining whether any rights or warrants
entitle the holders to subscribe for or purchase shares of Common Stock at less
than such Current Market Price, and in determining the aggregate offering price
of such shares of Common Stock, there shall be taken into account any
consideration received for such rights or warrants, the value of such
consideration if other than cash, to be determined by the Board of Directors.

         (d) In case the Company shall, by dividend or otherwise, distribute to
all holders of its Common Stock shares of any class of capital stock of the
Company (other than any dividends or distributions to which Section 12.4(a)
applies) or evidences of its indebtedness, cash or other assets, including
securities, but excluding (1) any rights or warrants referred to in Section
12.4(c), (2) any stock, securities or other property or assets (including cash)
distributed in connection with a reclassification, change, merger,
consolidation, statutory share exchange, combination, sale or conveyance to
which Section 12.11 hereof applies and (3) dividends and distributions paid
exclusively in cash (the securities described in foregoing clauses (1), (2) and
(3) hereinafter in this Section 12.4(d) called the "securities"), then, in each
such case, subject to the second succeeding paragraph of this Section 12.4(d),
the Conversion Price shall be reduced so that the same shall be equal to the
price determined by multiplying the Conversion Price in effect immediately prior
to the close of business on the Record Date (as defined in Section 12.4(g)) with
respect to such distribution by a fraction:

                             (i) the numerator of which shall be the Current
                  Market Price (determined as provided in Section 12.4(g)) on
                  such date less the fair market value (as determined by the
                  Board of Directors, whose determination shall be conclusive
                  and set forth in a Board Resolution) on such date of the
                  portion of the securities so distributed applicable to one
                  share of Common Stock (determined on the basis of the number
                  of shares of the Common Stock outstanding on the Record Date),
                  and

                             (ii) the denominator of which shall be such Current
                  Market Price.

Such reduction shall become effective immediately prior to the opening of
business on the day following the Record Date. However, in the event that the
then fair market value (as so determined) of the portion of the securities so
distributed applicable to one share of Common Stock is equal to or greater than
the Current Market Price on the Record Date, in lieu of the foregoing
adjustment, adequate provision shall be made so that each Holder shall have the
right to receive upon conversion of a Security (or any portion thereof)
the amount of securities such Holder would have received had such Holder
converted such Security (or portion thereof)


                                       70
<PAGE>


immediately prior to such Record Date. In the event that such dividend or
distribution is not so paid or made, the Conversion Price shall again be
adjusted to be the Conversion Price which would then be in effect if such
dividend or distribution had not been declared.

         If the Board of Directors determines the fair market value of any
distribution for purposes of this Section 12.4(d) by reference to the actual or
when issued trading market for any securities comprising all or part of such
distribution, it must in doing so consider the prices in such market over the
same period (the "Reference Period") used in computing the Current Market Price
pursuant to Section 12.4(g) to the extent possible, unless the Board of
Directors in a Board Resolution determines in good faith that determining the
fair market value during the Reference Period would not be in the best interest
of the Holder.

         Rights or warrants distributed by the Company to all holders of Common
Stock entitling the holders thereof to subscribe for or purchase shares of the
Company's capital stock (either initially or under certain circumstances), which
rights or warrants, until the occurrence of a specified event or events
("Trigger Event"):

                     (iii) are deemed to be transferred with such shares of
         Common Stock;

                     (iv) are not exercisable; and

                     (v) are also issued in respect of future issuances of
         Common Stock,

shall be deemed not to have been distributed for purposes of this Section
12.4(d) (and no adjustment to the Conversion Price under this Section 12.4(d)
will be required) until the occurrence of the earliest Trigger Event. If such
right or warrant is subject to subsequent events, upon the occurrence of which
such right or warrant shall become exercisable to purchase different securities,
evidences of indebtedness or other assets or entitle the holder to purchase a
different number or amount of the foregoing or to purchase any of the foregoing
at a different purchase price, then the occurrence of each such event shall be
deemed to be the date of issuance and record date with respect to a new right or
warrant (and a termination or expiration of the existing right or warrant
without exercise by the holder thereof). In addition, in the event of any
distribution (or deemed distribution) of rights or warrants, or any Trigger
Event or other event (of the type described in the preceding sentence) with
respect thereto, that resulted in an adjustment to the Conversion Price under
this Section 12.4(d):

                           (1) in the case of any such rights or warrants which
                  shall all have been redeemed or repurchased without exercise
                  by any holders thereof, the Conversion Price shall be
                  readjusted upon such final redemption or repurchase to give
                  effect to such distribution or Trigger Event, as the case may
                  be, as though it were a cash distribution, equal to the per
                  share redemption or repurchase price received by a holder of
                  Common Stock with respect to such rights or warrant (assuming
                  such holder had retained such rights or warrants), made to all
                  holders of Common Stock as of the date of such redemption or
                  repurchase, and



                                       71
<PAGE>


                           (2) in the case of such rights or warrants all of
                  which shall have expired or been terminated without exercise,
                  the Conversion Price shall be readjusted as if such rights and
                  warrants had never been issued.

         For purposes of this Section 12.4(d) and Sections 12.4(a), 12.4(b) and
12.4(c), any dividend or distribution to which this Section 12.4(d) is
applicable that also includes shares of Common Stock, a subdivision or
combination of Common Stock to which Section 12.4(c) applies, or rights or
warrants to subscribe for or purchase shares of Common Stock to which Section
12.4(c) applies (or any combination thereof), shall be deemed instead to be:

                           (3) a dividend or distribution of the evidences of
         indebtedness, assets, shares of capital stock, rights or warrants other
         than such shares of Common Stock, such subdivision or combination or
         such rights or warrants to which Sections 12.4(a), 12.4(b) and 12.4(c)
         apply, respectively (and any Conversion Price reduction required by
         this Section 12.4(d) with respect to such dividend or distribution
         shall then be made), immediately followed by

                           (4) a dividend or distribution of such shares of
         Common Stock, such subdivision or combination or such rights or
         warrants (and any further Conversion Price reduction required by
         Sections 12.4(a), 12.4(b) and 12.4(c) with respect to such dividend or
         distribution shall then be made), except:

                                    (A) the Record Date of such dividend or
                  distribution shall be substituted as (x) "the date fixed for
                  the determination of stockholders entitled to receive such
                  dividend or other distribution", "Record Date fixed for such
                  determinations" and "Record Date" within the meaning of
                  Section 12.4(a), (y) "the day upon which such subdivision
                  becomes effective" and "the day upon which such combination
                  becomes effective" within the meaning of Section 12.4(b), and
                  (z) as "the date fixed for the determination of stockholders
                  entitled to receive such rights or warrants", "the Record Date
                  fixed for the determination of the stockholders entitled to
                  receive such rights or warrants" and such "Record Date" within
                  the meaning of Section 12.4(c), and

                                    (B) any shares of Common Stock included in
                  such dividend or distribution shall not be deemed "outstanding
                  at the close of business on the date fixed for such
                  determination" within the meaning of Section 12.4(a) and any
                  reduction or increase in the number of shares of Common Stock
                  resulting from such subdivision or combination shall be
                  disregarded in connection with such dividend or distribution..

         (e) In case the Company shall, by dividend or otherwise, distribute to
all holders of its Common Stock cash (excluding any cash that is distributed
upon a reclassification, change, merger, consolidation, statutory share
exchange, combination, sale or conveyance to which Section 12.11 hereof applies
or as part of a distribution referred to in Section 12.4(d) hereof), in an
aggregate amount that, combined together with:



                                       72
<PAGE>


                           (1) the aggregate amount of any other such
                  distributions to all holders of Common Stock made exclusively
                  in cash within the 12 months preceding the date of payment of
                  such distribution, and in respect of which no adjustment
                  pursuant to this Section 12.4(e) has been made, and

                           (2) the aggregate of any cash plus the fair market
                  value (as determined by the Board of Directors, whose
                  determination shall be conclusive and set forth in a Board
                  Resolution) of consideration payable in respect of any tender
                  offer by the Company or any of its subsidiaries for all or any
                  portion of the Common Stock concluded within the 12 months
                  preceding the date of such distribution, and in respect of
                  which no adjustment pursuant to Section 12.4(f) hereof has
                  been made,

exceeds 10% of the product of the Current Market Price (determined as provided
in Section 12.4(g)) on the Record Date with respect to such distribution times
the number of shares of Common Stock outstanding on such date, then and in each
such case, immediately after the close of business on such date, the Conversion
Price shall be reduced so that the same shall equal the price determined by
multiplying the Conversion Price in effect immediately prior to the close of
business on such Record Date by a fraction:

                     (i) the numerator of which shall be equal to the Current
         Market Price on the Record Date less an amount equal to the quotient of
         (x) the excess of such combined amount over such 10% and (y) the number
         of shares of Common Stock outstanding on the Record Date, and

                     (ii) the denominator of which shall be equal to the Current
         Market Price on such date.

However, in the event that the then fair market value (as so determined) of the
portion of the securities so distributed applicable to one share of Common Stock
is equal to or greater than the Current Market Price on the Record Date, in lieu
of the foregoing adjustment, adequate provision shall be made so that each
Holder shall have the right to receive upon conversion of a Security (or any
portion thereof) the amount of cash such Holder would have received had such
Holder converted such Security (or portion thereof) immediately prior to such
Record Date. In the event that such dividend or distribution is not so paid or
made, the Conversion Price shall again be adjusted to be the Conversion Price
which would then be in effect if such dividend or distribution had not been
declared.

         (f) In case a tender offer made by the Company or any of its
subsidiaries for all or any portion of the Common Stock shall expire and such
tender offer (as amended upon the expiration thereof) shall require the payment
to stockholders (based on the acceptance (up to any maximum specified in the
terms of the tender offer) of Purchased Shares (as defined below)) of an
aggregate consideration having a fair market value (as determined by the Board
of Directors, whose determination shall be conclusive and set forth in a Board
Resolution) that combined together with:



                                       73
<PAGE>


                           (1) the aggregate of the cash plus the fair market
                  value (as determined by the Board of Directors, whose
                  determination shall be conclusive and set forth in a Board
                  Resolution), as of the expiration of such tender offer, of
                  consideration payable in respect of any other tender offers,
                  by the Company or any of its subsidiaries for all or any
                  portion of the Common Stock expiring within the 12 months
                  preceding the expiration of such tender offer and in respect
                  of which no adjustment pursuant to this Section 12.4(f) has
                  been made, and

                           (2) the aggregate amount of any distributions to all
                  holders of the Company's Common Stock made exclusively in cash
                  within 12 months preceding the expiration of such tender offer
                  and in respect of which no adjustment pursuant to Section
                  12.4(e) has been made, exceeds 10% of the product of the
                  Current Market Price (determined as provided in Section
                  12.4(g)) as of the last time (the "Expiration Time") tenders
                  could have been made pursuant to such tender offer (as it may
                  be amended) times the number of shares of Common Stock
                  outstanding (including any tendered shares) on the Expiration
                  Time, then, and in each such case, immediately prior to the
                  opening of business on the day after the date of the
                  Expiration Time, the Conversion Price shall be adjusted so
                  that the same shall equal the price determined by multiplying
                  the Conversion Price in effect immediately prior to close of
                  business on the date of the Expiration Time by a fraction:

                             (i) the numerator of which shall be the number of
                  shares of Common Stock outstanding (including any tendered
                  shares) at the Expiration Time multiplied by the Current
                  Market Price of the Common Stock on the Trading Day next
                  succeeding the Expiration Time, and

                             (ii) the denominator shall be the sum of (x) the
                  fair market value (determined as aforesaid) of the aggregate
                  consideration payable to stockholders based on the acceptance
                  (up to any maximum specified in the terms of the tender offer)
                  of all shares validly tendered and not withdrawn as of the
                  Expiration Time (the shares deemed so accepted, up to any such
                  maximum, being referred to as the "Purchased Shares") and (y)
                  the product of the number of shares of Common Stock
                  outstanding (less any Purchased Shares) on the Expiration Time
                  and the Current Market Price of the Common Stock on the
                  Trading Day next succeeding the Expiration Time.

Such reduction (if any) shall become effective immediately prior to the opening
of business on the day following the Expiration Time. In the event that the
Company is obligated to purchase shares pursuant to any such tender offer, but
the Company is permanently prevented by applicable law from effecting any such
purchases or all such purchases are rescinded, the Conversion Price shall again
be adjusted to be the Conversion Price which would then be in effect if such
tender offer had not been made. If the application of this Section 12.4(f) to
any tender offer would result in an increase in the Conversion Price, no
adjustment shall be made for such tender offer under this Section 12.4(f).



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<PAGE>


         (g) For purposes of this Section 12.4, the following terms shall have
the meanings indicated:

                           (1) "Current Market Price" shall mean the average of
                  the daily Closing Prices per share of Common Stock for the ten
                  consecutive Trading Days immediately prior to the date in
                  question; provided, however, that if:

                                      (i) the "ex" date (as hereinafter defined)
                           for any event (other than the issuance or
                           distribution requiring such computation) that
                           requires an adjustment to the Conversion Price
                           pursuant to Section 12.4(a), (b), (c), (d), (e) or
                           (f) occurs during such ten consecutive Trading Days,
                           the Closing Price for each Trading Day prior to the
                           "ex" date for such other event shall be adjusted by
                           multiplying such Closing Price by the same fraction
                           by which the Conversion Price is so required to be
                           adjusted as a result of such other event;

                                      (ii) the "ex" date for any event (other
                           than the issuance or distribution requiring such
                           computation) that requires an adjustment to the
                           Conversion Price pursuant to Section 12.4(a), (b),
                           (c), (d), (e) or (f) occurs on or after the "ex" date
                           for the issuance or distribution requiring such
                           computation and prior to the day in question, the
                           Closing Price for each Trading Day on and after the
                           "ex" date for such other event shall be adjusted by
                           multiplying such Closing Price by the reciprocal of
                           the fraction by which the Conversion Price is so
                           required to be adjusted as a result of such other
                           event; and

                                      (iii) the "ex" date for the issuance or
                           distribution requiring such computation is prior to
                           the day in question, after taking into account any
                           adjustment required pursuant to clause (i) or (ii) of
                           this proviso, the Closing Price for each Trading Day
                           on or after such "ex" date shall be adjusted by
                           adding thereto the amount of any cash and the fair
                           market value (as determined by the Board of Directors
                           in a manner consistent with any determination of such
                           value for purposes of Section 12.4(d) or (f), whose
                           determination shall be conclusive and set forth in a
                           Board Resolution) of the evidences of indebtedness,
                           shares of capital stock or assets being distributed
                           applicable to one share of Common Stock as of the
                           close of business on the day before such "ex" date.

For purposes of any computation under Section 12.4(f), the Current Market Price
of the Common Stock on any date shall be deemed to be the average of the daily
Closing Prices per share of Common Stock for such day and the next two
succeeding Trading Days; provided, however, that if the "ex" date for any event
(other than the tender offer requiring such computation) that requires an
adjustment to the Conversion Price pursuant to Section 12.4(a), (b), (c), (d),
(e) or (f) occurs on or after the Expiration Time for the tender or exchange
offer requiring such computation and prior to the day in question, the Closing
Price for each Trading Day on and after



                                       75
<PAGE>


the "ex" date for such other event shall be adjusted by multiplying such Closing
Price by the reciprocal of the fraction by which the Conversion Price is so
required to be adjusted as a result of such other event. For purposes of this
paragraph, the term "ex" date, when used:

                           (A) with respect to any issuance or distribution,
                  means the first date on which the Common Stock trades regular
                  way on the relevant exchange or in the relevant market from
                  which the Closing Price was obtained without the right to
                  receive such issuance or distribution;

                           (B) with respect to any subdivision or combination of
                  shares of Common Stock, means the first date on which the
                  Common Stock trades regular way on such exchange or in such
                  market after the time at which such subdivision or combination
                  becomes effective, and

                           (C) with respect to any tender or exchange offer,
                  means the first date on which the Common Stock trades regular
                  way on such exchange or in such market after the Expiration
                  Time of such offer.

         Notwithstanding the foregoing, whenever successive adjustments to the
         Conversion Price are called for pursuant to this Section 12.4, such
         adjustments shall be made to the Current Market Price as may be
         necessary or appropriate to effectuate the intent of this Section 12.4
         and to avoid unjust or inequitable results as determined in good faith
         by the Board of Directors.

                           (1) "fair market value" shall mean the amount which a
                  willing buyer would pay a willing seller in an arm's length
                  transaction.

                           (2) "Record Date" shall mean, with respect to any
                  dividend, distribution or other transaction or event in which
                  the holders of Common Stock have the right to receive any
                  cash, securities or other property or in which the Common
                  Stock (or other applicable security) is exchanged for or
                  converted into any combination of cash, securities or other
                  property, the date fixed for determination of stockholders
                  entitled to receive such cash, securities or other property
                  (whether such date is fixed by the Board of Directors or by
                  statute, contract or otherwise).

         (h) The Company may make such reductions in the Conversion Price, in
addition to those required by Sections 12.4(a), (b), (c), (d), (e) or (f), as
the Board of Directors considers to be advisable to avoid or diminish any income
tax to holders of Common Stock or rights to purchase Common Stock resulting from
any dividend or distribution of stock (or rights to acquire stock) or from any
event treated as such for income tax purposes.

         To the extent permitted by applicable law, the Company from time to
time may reduce the Conversion Price by any amount for any period of time if the
period is at least 20 days and the reduction is irrevocable during the period
and the Board of Directors determines in good faith that such reduction would be
in the best interests of the Company, which determination shall be



                                       76
<PAGE>


conclusive and set forth in a Board Resolution. Whenever the Conversion Price is
reduced pursuant to the preceding sentence, the Company shall mail to the
Trustee and each Holder at the address of such Holder as it appears in the
Register a notice of the reduction at least 15 days prior to the date the
reduced Conversion Price takes effect, and such notice shall state the reduced
Conversion Price and the period during which it will be in effect.

         (i) No adjustment in the Conversion Price shall be required unless such
adjustment would require an increase or decrease of at least 1% in such price;
provided, however, that any adjustments which by reason of this Section 12.4(i)
are not required to be made shall be carried forward and taken into account in
any subsequent adjustment. All calculations under this Article 12 shall be made
by the Company and shall be made to the nearest cent or to the nearest one
hundredth of a share, as the case may be. No adjustment need be made for a
change in the par value or no par value of the Common Stock.

         (j) In any case in which this Section 12.4 provides that an adjustment
shall become effective immediately after a Record Date for an event, the Company
may defer until the occurrence of such event (i) issuing to the Holder of any
Security converted after such Record Date and before the occurrence of such
event the additional shares of Common Stock issuable upon such conversion by
reason of the adjustment required by such event over and above the Common Stock
issuable upon such conversion before giving effect to such adjustment and (ii)
paying to such holder any amount in cash in lieu of any fraction pursuant to
Section 12.3 hereof.

         (k) For purposes of this Section 12.4, the number of shares of Common
Stock at any time outstanding shall not include shares held in the treasury of
the Company but shall include shares issuable in respect of scrip certificates
issued in lieu of fractions of shares of Common Stock. The Company will not pay
any dividend or make any distribution on shares of Common Stock held in the
treasury of the Company.

         (l) If the distribution date for the rights provided in the Company's
rights agreement, if any, occurs prior to the date a Security is converted, the
Holder of the Security who converts such Security after the distribution date is
not entitled to receive the rights that would otherwise be attached (but for the
date of conversion) to the shares of Common Stock received upon such conversion;
provided, however, that an adjustment shall be made to the Conversion Price
pursuant to clause 12.4(b) as if the rights were being distributed to the common
stockholders of the Company immediately prior to such conversion. If such an
adjustment is made and the rights are later redeemed, invalidated or terminated,
then a corresponding reversing adjustment shall be made to the Conversion Price,
on an equitable basis, to take account of such event.

         SECTION 12.5 NOTICE OF ADJUSTMENTS OF CONVERSION PRICE.

         Whenever the Conversion Price is adjusted as herein provided (other
than in the case of an adjustment pursuant to the second paragraph of Section
12.4(h) for which the notice required by such paragraph has been provided), the
Company shall promptly file with the Trustee and any Conversion Agent other than
the Trustee an Officers' Certificate setting forth the adjusted Conversion Price
and showing in reasonable detail the facts upon which such adjustment is based.
Promptly after delivery of such Officers' Certificate, the Company shall prepare
a notice



                                       77
<PAGE>


stating that the Conversion Price has been adjusted and setting forth the
adjusted Conversion Price and the date on which each adjustment becomes
effective, and shall mail such notice to each Holder at the address of such
Holder as it appears in the Register within 20 days of the effective date of
such adjustment. Failure to deliver such notice shall not effect the legality or
validity of any such adjustment.

         SECTION 12.6 NOTICE PRIOR TO CERTAIN ACTIONS.

         In case at any time after the date hereof:

                           (1) the Company shall declare a dividend (or any
         other distribution) on its Common Stock payable otherwise than in cash
         out of its capital surplus or its consolidated retained earnings;

                           (2) the Company shall authorize the granting to the
         holders of its Common Stock of rights or warrants to subscribe for or
         purchase any shares of capital stock of any class (or of securities
         convertible into shares of capital stock of any class) or of any other
         rights;

                           (3) there shall occur any reclassification of the
         Common Stock of the Company (other than a subdivision or combination of
         its outstanding Common Stock, a change in par value, a change from par
         value to no par value or a change from no par value to par value), or
         any merger, consolidation, statutory share exchange or combination to
         which the Company is a party and for which approval of any shareholders
         of the Company is required, or the sale, transfer or conveyance of all
         or substantially all of the assets of the Company; or

                           (4) there shall occur the voluntary or involuntary
         dissolution, liquidation or winding up of the Company;

the Company shall cause to be filed at each office or agency maintained for the
purpose of conversion of securities pursuant to Section 9.2 hereof, and shall
cause to be provided to the Trustee and all Holders in accordance with Section
14.2 hereof, at least 20 days (or 10 days in any case specified in clause (1) or
(2) above) prior to the applicable record or effective date hereinafter
specified, a notice stating:

                                    (A) the date on which a record is to be
                  taken for the purpose of such dividend, distribution, rights
                  or warrants, or, if a record is not to be taken, the date as
                  of which the holders of Common Stock of record to be entitled
                  to such dividend, distribution, rights or warrants are to be
                  determined, or

                                    (B) the date on which such reclassification,
                  merger, consolidation, statutory share exchange, combination,
                  sale, transfer, conveyance, dissolution, liquidation or
                  winding up is expected to become effective, and the date as of
                  which it is expected that holders of Common Stock of record
                  shall be entitled to exchange their shares of Common Stock for
                  securities, cash or other



                                       78
<PAGE>


                  property deliverable upon such reclassification, merger,
                  consolidation, statutory share exchange, sale, transfer,
                  dissolution, liquidation or winding up.

         Neither the failure to give such notice nor any defect therein shall
affect the legality or validity of the proceedings or actions described in
clauses (1) through (4) of this Section 12.6.

         SECTION 12.7 COMPANY TO RESERVE COMMON STOCK.

         The Company shall at all times use its best efforts to reserve and keep
available, free from preemptive rights, out of its authorized but unissued
Common Stock, for the purpose of effecting the conversion of Securities, the
full number of shares of fully paid and nonassessable Common Stock then issuable
upon the conversion of all Outstanding Securities.

         SECTION 12.8 TAXES ON CONVERSIONS.

         Except as provided in the next sentence, the Company will pay any and
all taxes (other than taxes on income) and duties that may be payable in respect
of the issue or delivery of shares of Common Stock on conversion of Securities
pursuant hereto. A Holder delivering a Security for conversion shall be liable
for and will be required to pay any tax or duty which may be payable in respect
of any transfer involved in the issue and delivery of shares of Common Stock in
a name other than that of the Holder of the Security or Securities to be
converted, and no such issue or delivery shall be made unless the Person
requesting such issue has paid to the Company the amount of any such tax or
duty, or has established to the satisfaction of the Company that such tax or
duty has been paid.

         SECTION 12.9 COVENANT AS TO COMMON STOCK.

         The Company covenants that all shares of Common Stock which may be
issued upon conversion of Securities will upon issue be fully paid and
nonassessable and, except as provided in Section 12.8, the Company will pay all
taxes, liens and charges with respect to the issue thereof.

         SECTION 12.10 CANCELLATION OF CONVERTED SECURITIES.

         All Securities delivered for conversion shall be delivered to the
Trustee to be canceled by or at the direction of the Trustee, which shall
dispose of the same as provided in Section 2.9.

         SECTION 12.11 EFFECT OF RECLASSIFICATION, CONSOLIDATION, MERGER OR
                       SALE.

         If any of following events occur, namely:

                                    (i) any reclassification or change of the
                  outstanding shares of Common Stock (other than a change in par
                  value, or from par value to no par value, or from no par value
                  to par value, or as a result of a subdivision or combination),



                                       79
<PAGE>


                                    (ii) any merger, consolidation, statutory
                  share exchange or combination of the Company with another
                  corporation as a result of which holders of Common Stock shall
                  be entitled to receive stock, securities or other property or
                  assets (including cash) with respect to or in exchange for
                  such Common Stock or

                                    (iii) any sale or conveyance of the
                  properties and assets of the Company as, or substantially as,
                  an entirety to any other corporation as a result of which
                  holders of Common Stock shall be entitled to receive stock,
                  securities or other property or assets (including cash) with
                  respect to or in exchange for such Common Stock,

the Company or the successor or purchasing corporation, as the case may be,
shall execute with the Trustee a supplemental indenture (which shall comply with
the TIA as in force at the date of execution of such supplemental indenture if
such supplemental indenture is then required to so comply) providing that such
Security shall be convertible into the kind and amount of shares of stock and
other securities or property or assets (including cash) which such Holder would
have been entitled to receive upon such reclassification, change, merger,
consolidation, statutory share exchange, combination, sale or conveyance had
such Securities been converted into Common Stock immediately prior to such
reclassification, change, merger, consolidation, statutory share exchange,
combination, sale or conveyance assuming such holder of Common Stock did not
exercise its rights of election, if any, as to the kind or amount of securities,
cash or other property receivable upon such merger, consolidation, statutory
share exchange, sale or conveyance (provided that, if the kind or amount of
securities, cash or other property receivable upon such merger, consolidation,
statutory share exchange, sale or conveyance is not the same for each share of
Common Stock in respect of which such rights of election shall not have been
exercised ("Non-Electing Share"), then for the purposes of this Section 12.11
the kind and amount of securities, cash or other property receivable upon such
merger, consolidation, statutory share exchange, sale or conveyance for each
Non-Electing Share shall be deemed to be the kind and amount so receivable per
share by a plurality of the Non-Electing Shares). Such supplemental indenture
shall provide for adjustments which shall be as nearly equivalent as may be
practicable to the adjustments provided for in this Article 12. If, in the case
of any such reclassification, change, merger, consolidation, statutory share
exchange, combination, sale or conveyance, the stock or other securities and
assets receivable thereupon by a holder of shares of Common Stock includes
shares of stock or other securities and assets of a corporation other than the
successor or purchasing corporation, as the case may be, in such
reclassification, change, merger, consolidation, statutory share exchange,
combination, sale or conveyance, then such supplemental indenture shall also be
executed by such other corporation and shall contain such additional provisions
to protect the interests of the Holders of the Securities as the Board of
Directors shall reasonably consider necessary by reason of the foregoing,
including to the extent practicable the provisions providing for the Repurchase
Rights set forth in Article 13 hereof.

         The Company shall cause notice of the execution of such supplemental
indenture to be mailed to each Holder, at the address of such Holder as it
appears on the Register, within 20 days



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<PAGE>


after execution thereof. Failure to deliver such notice shall not affect the
legality or validity of such supplemental indenture.

         The above provisions of this Section shall similarly apply to
successive reclassifications, mergers, consolidations, statutory share
exchanges, combinations, sales and conveyances.

         If this Section 12.11 applies to any event or occurrence, Section 12.4
hereof shall not apply.

         SECTION 12.12 RESPONSIBILITY OF TRUSTEE FOR CONVERSION PROVISIONS.

         The Trustee, subject to the provisions of Section 5.1 hereof, and any
Conversion Agent shall not at any time be under any duty or responsibility to
any Holder of Securities to determine whether any facts exist which may require
any adjustment of the Conversion Price, or with respect to the nature or intent
of any such adjustments when made, or with respect to the method employed, or
herein or in any supplemental indenture provided to be employed, in making the
same. Neither the Trustee, subject to the provisions of Section 5.1 hereof, nor
any Conversion Agent shall be accountable with respect to the validity or value
(of the kind or amount) of any Common Stock, or of any other securities or
property, which may at any time be issued or delivered upon the conversion of
any Security; and it or they do not make any representation with respect
thereto. Neither the Trustee, subject to the provisions of Section 5.1 hereof,
nor any Conversion Agent shall be responsible for any failure of the Company to
make any cash payment or to issue, transfer or deliver any shares of stock or
share certificates or other securities or property upon the surrender of any
Security for the purpose of conversion; and the Trustee, subject to the
provisions of Section 5.1 hereof, and any Conversion Agent shall not be
responsible or liable for any failure of the Company to comply with any of the
covenants of the Company contained in this Article.



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<PAGE>


                                   ARTICLE 13

                                  SUBORDINATION

         SECTION 13.1 SECURITIES SUBORDINATED TO SENIOR DEBT.

         The Company covenants and agrees, and each Holder of Securities, by
such Holder's acceptance thereof, likewise covenants and agrees, that the
Indebtedness represented by the Securities and the payment of the principal of
and premium, if any, and interest (including Liquidated Damages, if any) on each
and all of the Securities is hereby expressly subordinated and junior, to the
extent and in the manner set forth and as set forth in this Section 13.1, in
right of payment to the prior payment in full of all Senior Debt.

         (a) In the event of any distribution of assets of the Company upon any
dissolution, winding up, liquidation or reorganization of the Company, whether
in bankruptcy, insolvency, reorganization or receivership proceedings or upon an
assignment for the benefit of creditors or any other marshalling of the assets
and liabilities of the Company or otherwise, the holders of all Senior Debt
shall first be entitled to receive payment of the full amount due thereon in
respect of all such Senior Debt and all other amounts due or provision shall be
made for such amount in cash, or other payments satisfactory to the holders of
Senior Debt, before the Holders of any of the Securities are entitled to receive
any payment or distribution of any character, whether in cash, securities or
other property, on account of the principal of or premium, if any, or interest
(including Liquidated Damages, if any) on the Indebtedness evidenced by the
Securities.

         (b) In the event of any acceleration of Maturity of the Securities
because of an Event of Default, unless the full amount due in respect of all
Senior Debt is paid in cash or other form of payment satisfactory to the holders
of Senior Debt, no payment shall be made by the Company with respect to the
principal of, premium, if any, or interest (including Liquidated Damages, if
any) on the Securities or to acquire any of the Securities (including any
redemption, conversion or cash repurchase pursuant to the exercise of the
Repurchase Right), and the Company shall give prompt written notice of such
acceleration to such holders of Senior Debt.

         (c) In the event of and during the continuance of any default in
payment of the principal of or premium, if any, or interest on, rent or other
payment obligation in respect of, any Senior Debt, unless all such payments due
in respect of such Senior Debt have been paid in full in cash or other payments
satisfactory to the holders of Senior Debt, no payment shall be made by the
Company with respect to the principal of, premium, if any, or interest
(including Liquidated Damages, if any) on the Securities or to acquire any of
the Securities (including any redemption, conversion or cash repurchase pursuant
to the exercise of the Repurchase Right). The Company shall give prompt written
notice to the Trustee of any default under any Senior Debt or under any
agreement pursuant to which Senior Debt may have been issued.

         (d) During the continuance of any event of default with respect to any
Designated Senior Debt, as such event of default is defined under any such
Designated Senior Debt or in any agreement pursuant to which any Designated
Senior Debt has been issued (other than a default in payment of the principal of
or premium, if any, or interest on, rent or other payment obligation in



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<PAGE>


respect of any Designated Senior Debt), permitting the holder or holders of such
Designated Senior Debt to accelerate the maturity thereof (or in the case of any
lease, permitting the landlord either to terminate the lease or to require the
Company to make an irrevocable offer to terminate the lease following an event
of default thereunder), no payment shall be made by the Company, directly or
indirectly, with respect to principal of, premium, if any, or interest
(including Liquidated Damages, if any) on the Securities for 179 days following
notice in writing (a "Payment Blockage Notice") to the Company, from any holder
or holders of such Designated Senior Debt or their representative or
representatives or the trustee or trustees under any indenture or under which
any instrument evidencing any such Designated Senior Debt may have been issued,
that such an event of default has occurred and is continuing, unless such event
of default has been cured or waived or such Designated Senior Debt has been paid
in full; provided, however, if the maturity of such Designated Senior Debt is
accelerated (or in the case of any lease, as a result of such event of default,
the landlord under the lease has given the Company notice of its intention to
terminate the lease or to require the Company to make an irrevocable offer to
terminate the lease), no payment may be made on the Securities until such
Designated Senior Debt has been paid in full in cash or other payment
satisfactory to the holders of such Designated Senior Debt or such acceleration
(or termination, in the case of a lease) has been cured or waived.

         For purposes of this Section 13.1(d), such Payment Blockage Notice
shall be deemed to include notice of all other events of default under such
indenture or instrument which are continuing at the time of the event of default
specified in such Payment Blockage Notice. The provisions of this Section
13.1(d) shall apply only to one such Payment Blockage Notice given in any period
of 365 days with respect to any issue of Designated Senior Debt, and no such
continuing event of default that existed or was continuing on the date of
delivery of any Payment Blockage Notice shall be, or shall be made, the basis
for a subsequent Payment Blockage Notice.

         (e) In the event that, notwithstanding the foregoing provisions of
Sections 13.1(a), 13.1(b), 13.1(c) and 13.1(d), any payment on account of
principal, premium, if any, or interest (including Liquidated Damages, if any)
on the Securities shall be made by or on behalf of the Company and received by
the Trustee, by any Holder or by any Paying Agent (or, if the Company is acting
as its own Paying Agent, money for any such payment shall be segregated and held
in trust):

                           (i) after the occurrence of an event specified in
         Section 13.1(a) or 13.1(b), then, unless all Senior Debt is paid in
         full in cash, or provision shall be made therefor,

                           (ii)after the happening of an event of default of the
         type specified in Section 13.1(c) above, then, unless the amount of
         such Senior Debt then due shall have been paid in full, or provision
         made therefor or such event of default shall have been cured or waived,
         or

                           (iii) after the happening of an event of default of
         the type specified in Section 13.1(d) above and delivery of a Payment
         Blockage Notice, then, unless such



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<PAGE>


         event of default shall have been cured or waived or the 179-day period
         specified in Section 13.1(d) shall have expired,

such payment (subject, in each case, to the provisions of Section 13.7 hereof)
shall be held in trust for the benefit of, and shall be immediately paid over
to, the holders of Designated Senior Debt (unless an event described in Section
13.1(a), (b) or (c) has occurred, in which case the payment shall be held in
trust for the benefit of, and shall be immediately paid over to all holders of
Senior Debt) or their representative or representatives or the trustee or
trustees under any indenture under which any instruments evidencing any of the
Designated Senior Debt or Senior Debt, as the case may be, may have been issued,
as their interests may appear.

         SECTION 13.2 SUBROGATION.

         Subject to the payment in full of all Senior Debt to which the
Indebtedness evidenced by the Securities is in the circumstances subordinated as
provided in Section 13.1 hereof, the Holders of the Securities shall be
subrogated to the rights of the holders of such Senior Debt to receive payments
or distributions of cash, property or securities of the Company applicable to
such Senior Debt until all amounts owing on the Securities shall be paid in
full, and, as between the Company, its creditors other than holders of such
Senior Debt, and the Holders of the Securities, no such payment or distribution
made to the holders of Senior Debt by virtue of this Article which otherwise
would have been made to the holders of the Securities shall be deemed to be a
payment by the Company on account of such Senior Debt, provided that the
provisions of this Article are and are intended solely for the purpose of
defining the relative rights of the Holders of the Securities, on the one hand,
and the holders of Senior Debt, on the other hand.

         SECTION 13.3 OBLIGATION OF THE COMPANY IS ABSOLUTE AND UNCONDITIONAL.

         Nothing contained in this Article or elsewhere in this Indenture or in
the Securities is intended to or shall impair, as between the Company, its
creditors other than the holders of Senior Debt, and the Holders of the
Securities, the obligation of the Company, which is absolute and unconditional,
to pay to the Holders of the Securities the principal of and premium, if any,
and interest (including Liquidated Damages, if any) on the Securities as and
when the same shall become due and payable in accordance with their terms, or is
intended to or shall affect the relative rights of the Holders of the Securities
and creditors of the Company other than the holders of Senior Debt, nor shall
anything contained herein or therein prevent the Trustee or the Holder of any
Security from exercising all remedies otherwise permitted by applicable law upon
default under this Indenture, subject to the rights, if any, under this Article
of the holders of Senior Debt in respect of cash, property or securities of the
Company received upon the exercise of any such remedy.

         SECTION 13.4 MATURITY OF OR DEFAULT ON SENIOR DEBT.

         Upon the maturity of any Senior Debt by lapse of time, acceleration or
otherwise, all principal of or premium, if any, or interest on, rent or other
payment obligations in respect of all such matured Senior Debt shall first be
paid in full, or such payment shall have been duly



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<PAGE>


provided for, before any payment on account of principal, or premium, if any, or
interest (including Liquidated Damages, if any) is made upon the Securities.

         SECTION 13.5 PAYMENTS ON SECURITIES PERMITTED.

         Except as expressly provided in this Article, nothing contained in this
Article shall affect the obligation of the Company to make, or prevent the
Company from making, payments of the principal of, or premium, if any, or
interest (including Liquidated Damages, if any) on the Securities in accordance
with the provisions hereof and thereof, or shall prevent the Trustee or any
Paying Agent from applying any moneys deposited with it hereunder to the payment
of the principal of, or premium, if any, or interest (including Liquidated
Damages, if any) on the Securities.

         SECTION 13.6 EFFECTUATION OF SUBORDINATION BY TRUSTEE.

         Each Holder of Securities, by such Holder's acceptance thereof,
authorizes and directs the Trustee on such Holder's behalf to take such action
as may be necessary or appropriate to effectuate the subordination provided in
this Article and appoints the Trustee such Holder's attorney-in-fact for any and
all such purposes.

         Upon any payment or distribution of assets of the Company referred to
in this Article, the Trustee and the Holders of the Securities shall be entitled
to rely upon any order or decree made by any court of competent jurisdiction in
which any such dissolution, winding up, liquidation or reorganization proceeding
affecting the affairs of the Company is pending or upon a certificate of the
trustee in bankruptcy, receiver, assignee for the benefit of creditors,
liquidating trustee or agent or other Person making any payment or distribution,
delivered to the Trustee or to the Holders of the Securities, for the purpose of
ascertaining the Persons entitled to participate in such payment or
distribution, and as to other facts pertinent to the right of such Persons under
this Article, and if such evidence is not furnished, the Trustee may defer any
payment to such Persons pending judicial determination as to the right of such
Persons to receive such payment.

         SECTION 13.7 KNOWLEDGE OF TRUSTEE.

         Notwithstanding the provision of this Article or any other provisions
of this Indenture, the Trustee shall not be charged with knowledge of the
existence of any Senior Debt, of any default in payment of principal of,
premium, if any, or interest on, rent or other payment obligation in respect of
any Senior Debt, or of any facts which would prohibit the making of any payment
of moneys to or by the Trustee, or the taking of any other action by the
Trustee, unless a Responsible Officer of the Trustee having responsibility for
the administration of the trust established by this Indenture shall have
received written notice thereof from the Company, any Holder of Securities, any
Paying or Conversion Agent of the Company or the holder or representative of any
class of Senior Debt, and, prior to the receipt of any such written notice, the
Trustee shall be entitled in all respects to assume that no such default or
facts exist; provided, however, that unless on the third Business Day prior to
the date upon which by the terms hereof any such moneys may become payable for
any purpose the Trustee shall have received the notice provided for in this
Section 13.7, then, anything herein contained to the contrary



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<PAGE>


notwithstanding, the Trustee shall have full power and authority to receive such
moneys and apply the same to the purpose for which they were received, and shall
not be affected by any notice to the contrary which may be received by it on or
after such date.

         SECTION 13.8 TRUSTEE'S RELATION TO SENIOR DEBT.

         The Trustee shall be entitled to all the rights set forth in this
Article with respect to any Senior Debt at the time held by it, to the same
extent as any other holder of Senior Debt and nothing in this Indenture shall
deprive the Trustee of any of its rights as such holder.

         Nothing contained in this Article shall apply to claims of or payments
to the Trustee under or pursuant to Section 5.8 hereof.

         With respect to the holders of Senior Debt, the Trustee undertakes to
perform or to observe only such of its covenants and obligations as are
specifically set forth in this Article, and no implied covenants or obligations
with respect to the holders of Senior Debt shall be read into this Indenture
against the Trustee. The Trustee shall not be deemed to owe any fiduciary duty
to the holders of Senior Debt and the Trustee shall not be liable to any holder
of Senior Debt if it shall pay over or deliver to Holders, the Company or any
other Person moneys or assets to which any holder of Senior Debt shall be
entitled by virtue of this Article or otherwise.

         SECTION 13.9 RIGHTS OF HOLDERS OF SENIOR DEBT NOT IMPAIRED.

         No right of any present or future holder of any Senior Debt to enforce
the subordination herein shall at any time or in any way be prejudiced or
impaired by any act or failure to act on the part of the Company or by any
noncompliance by the Company with the terms, provisions and covenants of this
Indenture, regardless of any knowledge thereof any such holder may have or be
otherwise charged with.

         SECTION 13.10 MODIFICATION OF TERMS OF SENIOR DEBT.

         Any renewal or extension of the time of payment of any Senior Debt or
the exercise by the holders of Senior Debt of any of their rights under any
instrument creating or evidencing Senior Debt, including without limitation the
waiver of default thereunder, may be made or done all without notice to or
assent from the Holders of the Securities or the Trustee.

         No compromise, alteration, amendment, modification, extension, renewal
or other change of, or waiver, consent or other action in respect of, any
liability or obligation under or in respect of, or of any of the terms,
covenants or conditions of any indenture or other instrument under which any
Senior Debt is outstanding or of such Senior Debt, whether or not such release
is in accordance with the provisions or any applicable document, shall in any
way alter or affect any of the provisions of this Article or of the Securities
relating to the subordination thereof.

         SECTION 13.11 CERTAIN CONVERSIONS NOT DEEMED PAYMENT.

         For the purposes of this Article 13 only:



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<PAGE>


                           (1) the issuance and delivery of junior securities
                  upon conversion of Securities in accordance with Article 12
                  hereof shall not be deemed to constitute a payment or
                  distribution on account of the principal of, premium, if any,
                  or interest (including Liquidated Damages, if any) on
                  Securities or on account of the purchase or other acquisition
                  of Securities, and

                           (2) the payment, issuance or delivery of cash (except
                  in satisfaction of fractional shares pursuant to Section 12.3
                  hereof), property or securities (other than junior securities)
                  upon conversion of a Security shall be deemed to constitute
                  payment on account of the principal of, premium, if any, or
                  interest (including Liquidated Damages, if any) on such
                  Security.

For the purposes of this Section 13.11, the term "junior securities" means:

                  (a)      shares of any common stock of the Company or

                  (b) other securities of the Company that are subordinated in
         right of payment to all Senior Debt that may be outstanding at the time
         of issuance or delivery of such securities to substantially the same
         extent as, or to a greater extent that, the Securities are so
         subordinated as provided in this Article.

Nothing contained in this Article 13 or elsewhere in this Indenture or in the
Securities is intended to or shall impair, as among the Company, its creditors
(other than holders of Senior Debt) and the Holders of Securities, the right,
which is absolute and unconditional, of the Holder of any Security to convert
such Security in accordance with Article 12 hereof.



                                       87

<PAGE>


                                   ARTICLE 14

                     OTHER PROVISIONS OF GENERAL APPLICATION

         SECTION 14.1 TRUST INDENTURE ACT CONTROLS.

         This Indenture is subject to the provisions of the TIA which are
required to be part of this Indenture, and shall, to the extent applicable, be
governed by such provisions.

         SECTION 14.2 NOTICES.

         Any notice or communication to the Company or the Trustee is duly given
if in writing and delivered in person or mailed by first-class mail to the
address set forth below:

         (a)      if to the Company:

                           Inhale Therapeutic Systems, Inc.
                           150 Industrial Road
                           San Carlos, California
                           Attention:  Stephen L. Hurst, Esq.

                  with a copy to:

                           Cooley Godward LLP
                           3000 Sand Hill Road
                           Building #3, Suite 230
                           Menlo Park, California 94025
                           Attention:  Mark P. Tanoury, Esq.

         (b)      if to the Trustee:

                           Chase Manhattan Bank and Trust Company, National
                           Association
                           101 California Street
                           Suite 2725
                           San Francisco, California 94111
                           Attention:  Corporate Trust Administration

The Company or the Trustee by notice to the other may designate additional or
different addresses for subsequent notices or communications.

         Any notice or communication to a Holder shall be mailed by first-class
mail to his address shown on the Register kept by the Registrar. Failure to mail
a notice or communication to a Holder or any defect in such notice or
communication shall not affect its sufficiency with respect to other Holders.



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<PAGE>


         If a notice or communication is mailed or sent in the manner provided
above within the time prescribed, it is duly given as of the date it is mailed,
whether or not the addressee receives it, except that notice to the Trustee
shall only be effective upon receipt thereof by the Trustee.

         If the Company mails a notice or communication to Holders, it shall
mail a copy to the Trustee at the same time.

         SECTION 14.3 COMMUNICATION BY HOLDERS WITH OTHER HOLDERS.

         Holders may communicate pursuant to Section 312(b) of the TIA with
other Holders with respect to their rights under the Securities or this
Indenture. The Company, the Trustee, the Registrar and anyone else shall have
the protection of Section 312(c) of the TIA.

         SECTION 14.4 ACTS OF HOLDERS OF SECURITIES.

         (a) Any request, demand, authorization, direction, notice, consent,
waiver or other action provided by this Indenture to be given or taken by
Holders of Securities may be embodied in and evidenced by:

                  (1) one or more instruments of substantially similar tenor
         signed by such Holders in person or by agent or proxy duly appointed in
         writing;

                  (2) the record of Holders of Securities voting in favor
         thereof, either in person or by proxies duly appointed in writing, at
         any meeting of Holders of Securities duly called and held in accordance
         with the provisions of Article 8; or

                  (3) a combination of such instruments and any such record.

Except as herein otherwise expressly provided, such action shall become
effective when such instrument or instruments or record or both are delivered to
the Trustee and, where it is hereby expressly required, to the Company. Such
instrument or instruments and record (and the action embodied therein and
evidenced thereby) are herein sometimes referred to as the "Act" of the Holders
of Securities signing such instrument or instruments and so voting at such
meeting. Proof of execution of any such instrument or of a writing appointing
any such agent or proxy, or of the holding by any Person of a Security, shall be
sufficient for any purpose of this Indenture and (subject to Section 5.1 hereof)
conclusive in favor of the Trustee and the Company if made in the manner
provided in this Section. The record of any meeting of Holders of Securities
shall be proved in the manner provided in Section 8.6 hereof.

         (b) The fact and date of the execution by any Person of any such
instrument or writing may be provided in any manner which the Trustee reasonably
deems sufficient.

         (c) The principal amount and serial numbers of Securities held by any
Person, and the date of such Person holding the same, shall be proved by the
Register.

         (d) Any request, demand, authorization, direction, notice, consent,
election, waiver or other Act of the Holders of any Security shall bind every
future Holder of the same Security and



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<PAGE>


the Holder of every Security issued upon the registration of transfer thereof or
in exchange therefor or in lieu thereof in respect of anything done, omitted or
suffered to be done by the Trustee or the Company in reliance thereon, whether
or not notation of such action is made upon such Security.

         SECTION 14.5 CERTIFICATE AND OPINION AS TO CONDITIONS PRECEDENT.

         In any case where several matters are required to be certified by, or
covered by an opinion of, any specified Person, it is not necessary that all
such matters be certified by, or covered by the opinion of, only one such
Person, or that they be so certified or covered by only one document, but one
such Person may certify or give an opinion with respect to some matters and one
or more other such Persons as to other matters, and any such Person may certify
or give an opinion as to such matters in one or several documents.

         Any certificate or opinion of an officer of the Company may be based,
insofar as it relates to legal matters, upon an Opinion of Counsel, unless such
officer knows, or in the exercise of reasonable care should know, that the
Opinion of Counsel with respect to the matters upon which such certificate or
opinion is based is erroneous. Any such Opinion of Counsel may be based, insofar
as it relates to factual matters, upon a certificate or representations by, an
officer or officers of the Company stating that the information with respect to
such factual matters is in the possession of the Company, unless such counsel
knows, or in the exercise of reasonable care should know, that the certificate
or representations with respect to such matters are erroneous.

         Where any Person is required to make, give or execute two or more
applications, requests, consents, certificates, statements, opinions or other
instruments under this Indenture, they may, but need not, be consolidated and
form one instrument.

         Upon any application or request by the Company to the Trustee to take
any action under any provision of this Indenture, the Company shall furnish to
the Trustee an Officers' Certificate stating that all conditions precedent, if
any, provided for in this Indenture relating to the proposed action have been
complied with and an Opinion of Counsel stating that in the opinion of such
Counsel all such conditions precedent, if any, have been complied with, except
that in the case of any such application or request as to which the furnishing
of such documents is specifically required by any provision of this Indenture
relating to such particular application or request, no additional certificate or
opinion need be furnished.

         SECTION 14.6 STATEMENTS REQUIRED IN CERTIFICATE OR OPINION.

         Each certificate or opinion with respect to compliance with a condition
or covenant provided for in this Indenture shall include:

                           (1) a statement that each individual signing such
         certificate or opinion on behalf of the Company has read such covenant
         or condition and the definitions herein relating thereto;



                                       90
<PAGE>


                           (2) a brief statement as to the nature and scope of
         the examination or investigation upon which the statements or opinions
         contained in such certificate or opinion are based;

                           (3) a statement that, in the opinion of each such
         individual, he has made such examination or investigation as is
         necessary to enable him to express an informed opinion as to whether or
         not such covenant or condition has been complied with; and

                           (4) a statement as to whether, in the opinion of each
         such individual, such condition or covenant has been complied with.

         SECTION 14.7 EFFECT OF HEADINGS AND TABLE OF CONTENTS.

         The Article and Section headings herein and the Table of Contents are
for convenience only and shall not affect the construction hereof.

         SECTION 14.8 SUCCESSORS AND ASSIGNS.

         All covenants and agreements in this Indenture by the Company shall
bind its successors and assigns, whether so expressed or not.

         SECTION 14.9 SEPARABILITY CLAUSE.

         In case any provision in this Indenture or the Securities shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.

         SECTION 14.10 BENEFITS OF INDENTURE.

         Nothing contained in this Indenture or in the Securities, express or
implied, shall give to any Person, other than the parties hereto and their
successors hereunder, the holders of Senior Debt and the Holders of Securities,
any benefit or legal or equitable right, remedy or claim under this Indenture.

         SECTION 14.11 GOVERNING LAW.

         THIS INDENTURE AND THE SECURITIES SHALL BE GOVERNED BY, AND CONSTRUED
IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

         SECTION 14.12 COUNTERPARTS.

         This instrument may be executed in any number of counterparts, each of
which when so executed shall be deemed to be an original but all such
counterparts shall together constitute but one and the same instrument.



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<PAGE>


         SECTION 14.13 LEGAL HOLIDAYS.

         In any case where any Interest Payment Date, Redemption Date or Stated
Maturity of any Security or the last day on which a Holder of a Security has a
right to convert such Security shall not be a Business Day at any Place of
Payment or Place of Conversion, then (notwithstanding any other provision of
this Indenture or of the Securities) payment of interest (including Liquidated
Damages, if any) or principal or premium, if any, or conversion of the
Securities, need not be made at such Place of Payment or Place of Conversion on
such day, but may be made on the next succeeding Business Day at such Place of
Payment or Place of Conversion with the same force and effect as if made on the
Interest Payment Date or Redemption Date or at the Stated Maturity or on such
last day for conversion, provided, that in the case that payment is made on such
succeeding Business Day, no interest shall accrue on the amount so payable for
the period from and after such Interest Payment Date, Redemption Date or Stated
Maturity, as the case may be.

         SECTION 14.14 RECOURSE AGAINST OTHERS.

         No recourse for the payment of the principal of or premium, if any, or
interest (including Liquidated Damages, if any) on any Security, or for any
claim based thereon or otherwise in respect thereof, shall be had against any
incorporator, shareholder, officer or director, as such, past, present or
future, of the Company or of any successor corporation, whether by virtue of any
constitution, statute or rule of law or by the enforcement of any assessment or
penalty or otherwise, all such liability being, by the acceptance thereof and as
part of the consideration for the issue thereof, expressly waived and released.



                                       92
<PAGE>


         IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be
duly executed all as of the day and year first above written.

                                          INHALE THERAPEUTIC SYSTEMS, INC.


                                          By:
                                             ----------------------------------
                                                   Name:
                                                   Title:


                                          CHASE MANHATTAN BANK AND TRUST
                                          COMPANY, NATIONAL ASSOCIATION


                                          By:
                                             ----------------------------------
                                                   Name:
                                                   Title:



                                       93
<PAGE>



                                                                       EXHIBIT A

                                FORM OF SECURITY

                               [FACE OF SECURITY]

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE
DEPOSITORY TRUST COMPANY ("DTC") TO INHALE THERAPEUTIC SYSTEMS, INC. (OR ITS
SUCCESSOR) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, CONVERSION OR
PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR
IN SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND
ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED
BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE
HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.(1)

THE SECURITY EVIDENCED BY THIS CERTIFICATE HAS NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR ANY STATE
SECURITIES LAWS, AND MAY NOT BE OFFERED OR SOLD WITHIN THE UNITED STATES OR TO,
OR FOR THE ACCOUNT OR BENEFIT OF, U.S. PERSONS EXCEPT AS SET FORTH IN THE
FOLLOWING SENTENCE. BY ACQUISITION HEREOF, THE HOLDER (1) REPRESENTS THAT IT IS
A "QUALIFIED INSTITUTIONAL BUYER" AS DEFINED IN RULE 144A UNDER THE SECURITIES
ACT; (2) AGREES THAT IT WILL NOT WITHIN TWO YEARS AFTER THE ORIGINAL ISSUANCE OF
THIS SECURITY RESELL OR OTHERWISE TRANSFER THE SECURITY EVIDENCED HEREBY OR THE
COMMON STOCK ISSUABLE UPON CONVERSION OF SUCH SECURITY EXCEPT (A) TO THE COMPANY
OR ANY SUBSIDIARY THEREOF, (B) TO A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE
WITH RULE 144A UNDER THE SECURITIES ACT, (C) PURSUANT TO THE EXEMPTION FROM
REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT (IF AVAILABLE) OR (D)
PURSUANT TO A REGISTRATION STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE
SECURITIES ACT AND WHICH CONTINUES TO BE EFFECTIVE AT THE TIME OF SUCH TRANSFER;
AND (3) AGREES THAT IT WILL DELIVER TO EACH PERSON TO WHOM THE SECURITY
EVIDENCED HEREBY IS TRANSFERRED (OTHER THAN A TRANSFER PURSUANT TO CLAUSE 2(D)
ABOVE) A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS LEGEND. IN CONNECTION WITH
ANY TRANSFER OF THE SECURITY EVIDENCED HEREBY WITHIN TWO YEARS AFTER THE
ORIGINAL ISSUANCE OF SUCH SECURITY (OTHER THAN A TRANSFER PURSUANT TO CLAUSE
(2)(D) ABOVE), THE HOLDER MUST CHECK THE APPROPRIATE BOX SET FORTH ON THE
REVERSE HEREOF RELATING TO THE MANNER OF SUCH TRANSFER AND SUBMIT THIS
CERTIFICATE TO THE TRUSTEE (OR ANY SUCCESSOR TRUSTEE, AS APPLICABLE). IF THE
PROPOSED TRANSFER IS

- -------------------------
(1) This legend should be included only if the Security is issued in global form



                                       94
<PAGE>


PURSUANT TO CLAUSE (2)(C) ABOVE, THE HOLDER MUST, PRIOR TO SUCH TRANSFER,
FURNISH TO THE TRUSTEE (OR ANY SUCCESSOR TRUSTEE, AS APPLICABLE), SUCH
CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS THE COMPANY MAY
REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS BEING MADE PURSUANT TO AN
EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT. THIS LEGEND WILL BE REMOVED UPON THE EARLIER
OF THE TRANSFER OF THE SECURITY EVIDENCED HEREBY PURSUANT TO CLAUSE (2)(D) ABOVE
OR THE EXPIRATION OF TWO YEARS FROM THE ORIGINAL ISSUANCE OF THE SECURITY
EVIDENCED HEREBY. AS USED HEREIN, THE TERMS "UNITED STATES" AND "U.S. PERSON"
HAVE THE MEANINGS GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT.



                                      A-2
<PAGE>


                        INHALE THERAPEUTIC SYSTEMS, INC.

                    5% Convertible Subordinated Note due 2007

                                                           CUSIP NO. 457 191AD 6

No.________                                                         $___________

                  INHALE THERAPEUTIC SYSTEMS, INC., a Delaware corporation (the
"Company", which term includes any successor corporation under the Indenture
hereinafter referred to), for value received, hereby promises to pay to       ,
or its registered assigns, the principal sum of         U.S. Dollars ($       )
on February 8, 2007.

                  Interest Payment Dates:  February 8 and August 8, commencing
                  August 8, 2000

                  Regular Record Dates:  January 24 and July 24

                  Reference is hereby made to the further provisions of this
Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place.



                                      A-3
<PAGE>


                  IN WITNESS WHEREOF, the Company has caused this Security to be
duly executed manually or by facsimile by its duly authorized officers.

Dated:  February 8, 2000                   INHALE THERAPEUTIC SYSTEMS, INC.


                                           By:
                                              ----------------------------------
                                                    Name:
                                                    Title:


                                           By:
                                               ---------------------------------
                                                    Name:
                                                    Title:


Trustee's Certificate of Authentication

This is one of the 5% Convertible Subordinated
Notes due 2007 described in the within-named
Indenture.

CHASE MANHATTAN BANK AND TRUST
COMPANY, NATIONAL ASSOCIATION,
as Trustee

By:
   ---------------------------
      Authorized Signatory

Dated: __________, 2000



                                      A-4
<PAGE>


                              [REVERSE OF SECURITY]

                        INHALE THERAPEUTIC SYSTEMS, INC.

                    5% Convertible Subordinated Note due 2007

         Capitalized terms used herein but not defined shall have the meanings
assigned to them in the Indenture referred to below unless otherwise indicated.

1.   Principal and Interest.

         Inhale Therapeutic Systems, Inc., a Delaware corporation (the
"Company") promises to pay interest on the principal amount of this Security at
the Interest Rate from the date of issuance until repayment at Maturity,
redemption or repurchase. The Company will pay interest on this Security
semiannually in arrears on February 8 and August 8 of each year (each an
"Interest Payment Date"), commencing August 8, 2000.

         Interest on the Securities shall be computed (i) for any full
semiannual period for which a particular Interest Rate is applicable on the
basis of a 360-day year of twelve 30-day months and (ii) for any period for
which a particular Interest Rate is applicable shorter than a full semiannual
period for which interest is calculated, on the basis of a 30-day month and, for
such periods of less than a month, the actual number of days elapsed over a
30-day month.

         A Holder of any Security at the close of business on a Regular Record
Date shall be entitled to receive interest on such Security on the corresponding
Interest Payment Date. A Holder of any Security which is converted after the
close of business on a Regular Record Date and prior to the corresponding
Interest Payment Date (other than any Security whose Maturity is prior to such
Interest Payment Date) shall be entitled to receive interest on the principal
amount of such Security, notwithstanding the conversion of such Security prior
to such Interest Payment Date. However, any such Holder which surrenders any
such Security for conversion during the period between the close of business on
such Regular Record Date and ending with the opening of business on the
corresponding Interest Payment Date shall be required to pay the Company an
amount equal to the interest on the principal amount of such Security so
converted, which is payable by the Company to such Holder on such Interest
Payment Date, at the time such Holder surrenders such Security for conversion.
Notwithstanding the foregoing, any such Holder which surrenders for conversion
any Security which has been called for redemption by the Company in a notice of
redemption given by the Company pursuant to Section 10.5 of the Indenture shall
be entitled to receive (and retain) such interest and need not pay the Company
an amount equal to the interest on the principal amount of such Security so
converted at the time such Holder surrenders such Security for conversion.

         In accordance with the terms of the Resale Registration Rights
Agreement, dated February 8, 2000, between the Company and Merrill Lynch & Co.,
Merrill Lynch, Pierce, Fenner & Smith Incorporated, Deutsche Bank Securities
Inc., Lehman Brothers Inc. and U.S. Bancorp Piper Jaffray Inc., during the first
90 days following a Registration Default (as defined in the



                                      A-5
<PAGE>


Resale Registration Rights Agreement), the Interest Rate borne by the Securities
shall be increased by 0.25% on:

                  (A) May 9, 2000, if the shelf registration statement (the
         "Shelf Registration Statement") is not filed prior to or on May 8,
         2000;

                  (B) August 7, 2000, if the Shelf Registration Statement is not
         declared effective by the Securities and Exchange Commission prior to
         or on August 4, 2000;

                  (C) the day after the fifth Business Day after the Shelf
         Registration Statement, previously declared effective, ceases to be
         effective or fails to be usable, if a post-effective amendment (or
         report filed pursuant to the Exchange Act) that cures the Shelf
         Registration Statement is not filed with the Securities and Exchange
         Commission during such five Business Day period; or

                  (D) the day following the 45th or 60th day, as the case may
         be, of any period that the prospectus contained in the Shelf
         Registration Statement has been suspended, if such suspension has not
         been terminated.

From and after the 91st day following such Registration Default, the Interest
Rate borne by the Securities shall be increased by 0.50%. In no event shall the
Interest Rate borne by the Securities be increased by more than 0.50%.

         Any amount of additional interest will be payable in cash semiannually,
in arrears, on each Interest Payment Date and will cease to accrue on the date
the Registration Default is cured. The Holder of this Security is entitled to
the benefits of the Resale Registration Rights Agreement.

2.   Method of Payment.

         Interest on any Security which is payable, and is punctually paid or
duly provided for, on any Interest Payment Date shall be paid to the person in
whose name that Security (or one or more Predecessor Securities) is registered
at the close of business on the Regular Record Date for such interest.

         Principal of, and premium, if any, and interest on, Global Securities
will be payable to the Depositary in immediately available funds.

         Principal and premium, if any, on Physical Securities will be payable
at the office or agency of the Company maintained for such purpose, initially
the Corporate Trust Office of the Trustee. Interest on Physical Securities will
be payable by (i) U.S. Dollar check drawn on a bank in The City of New York
mailed to the address of the Person entitled thereto as such address shall
appear in the Register, or (ii) upon application to the Registrar not later than
the relevant Record Date by a Holder of an aggregate principal amount in excess
of $5,000,000, wire transfer in immediately available funds.



                                      A-6
<PAGE>


3.   Paying Agent and Registrar.

         Initially, Chase Manhattan Bank and Trust Company, National
Association, the Trustee under the Indenture, will act as Paying Agent and
Registrar. The Company may change the Paying Agent or Registrar without notice
to any Holder.

4.   Indenture.

         The Company issued this Security under an Indenture, dated as of
February 8, 2000 (the "Indenture"), between the Company and Chase Manhattan Bank
and Trust Company, National Association, as trustee (the "Trustee"). The terms
of the Security include those stated in the Indenture and those made part of the
Indenture by reference to the Trust Indenture Act of 1939, as amended ("TIA").
This Security is subject to all such terms, and Holders are referred to the
Indenture and the TIA for a statement of all such terms. To the extent permitted
by applicable law, in the event of any inconsistency between the terms of this
Security and the terms of the Indenture, the terms of the Indenture shall
control.

5.   Provisional Redemption.

         The Securities may be redeemed at the election of the Company, as a
whole or from time to time in part or any date, at any time prior to February 8,
2003 (a "Provisional Redemption"), at a Redemption Price equal to $1,000 per
$1,000 principal amount of the Securities plus accrued and unpaid interest, if
any, to but excluding the date of redemption (the "Provisional Redemption Date")
if (i) the Closing Price of the Common Stock has exceeded 150% of the Conversion
Price (as may be adjusted from time to time) then in effect for at least 20
trading Days in any consecutive 30-Trading Day period ending on the Trading Day
prior to the date of mailing of the provisional notice of redemption upon not
less than 20 nor more than 60 days notice (the "Notice Date'), and (ii) a
registration statement covering resales of the Securities and Common Stock
issuable upon the conversion thereof is effective and available for use and is
expected to remain effective for the 30 days following the Provisional
Redemption Date.

         Upon any such Provisional Redemption, the Company shall make an
additional payment in cash (the "Make-Whole Payment") to holders of the
Securities called for redemption, including those Securities converted into
Common Stock between the Notice Date and the Provisional Redemption Date, in an
amount equal to $137.93 per $1,000 principal amount of the Securities, less the
amount of any interest actually paid on the Securities before the Notice Date.

6.   Optional Redemption.

         Except as provided above, this Security is not redeemable prior to
February 8, 2003. This Security may be redeemed in whole or in part, upon not
less than 20 nor more than 60 days' notice, at any time on or after February 8,
2003, at the option of the Company, at the Redemption Prices (expressed as
percentages of the principal amount) set forth below, plus any interest accrued
but unpaid to the Redemption Date.

                  During the Twelve Months



                                      A-7
<PAGE>


<TABLE>
<CAPTION>

                  Commencing                                                             Redemption Prices
                  ----------                                                             -----------------
                  <S>                                                                              <C>
                  February 8, 2003..............................................                   102.90%
                  February 8, 2004..............................................                   102.10%
                  February 8, 2005..............................................                   101.40%
                  February 8, 2006..............................................                   100.70%
</TABLE>


         Securities in original denominations larger than $1,000 may be redeemed
in part. If any Security selected for partial redemption is converted in part
before termination of the conversion right with respect to the portion of the
Security so selected, the converted portion of such Security shall be deemed to
be the portion selected for redemption (provided, however, that the Holder of
such Security so converted and deemed redeemed shall not be entitled to any
additional interest payment as a result of such deemed redemption than such
Holder would have otherwise been entitled to receive upon conversion of such
Security). Securities which have been converted during a selection of Securities
to be redeemed may be treated by the Trustee as Outstanding for the purpose of
such selection.

         On and after the Redemption Date, interest ceases to accrue on
Securities or portions of Securities called for redemption, unless the Company
defaults in the payment of the Redemption Price.

         Notice of redemption will be given by the Company to the Holders as
provided in the Indenture.

7.   Repurchase Right Upon a Change of Control.

         If a Change in Control occurs, the Holder of Securities, at the
Holder's option, shall have the right, in accordance with the provisions of the
Indenture, to require the Company to repurchase the Securities (or any portion
of the principal amount hereof that is at least $1,000 or an integral multiple
thereof, provided that the portion of the principal amount of this Security to
be Outstanding after such repurchase is at least equal to $1,000) at the
Repurchase Price in cash, plus any interest accrued and unpaid to the Repurchase
Date.

         Subject to the conditions provided in the Indenture, the Company may
elect to pay the Repurchase Price by delivering a number of shares of Common
Stock equal to (i) the Repurchase Price divided by (ii) 95% of the average of
the Closing Prices per share for the five consecutive Trading Days immediately
preceding and including the third Trading Day prior to the Repurchase Date.

         No fractional shares of Common Stock will be issued upon repurchase of
any Securities. Instead of any fractional share of Common Stock which would
otherwise be issued upon conversion of such Securities, the Company shall pay a
cash adjustment as provided in the Indenture.



                                      A-8
<PAGE>


         A Company Notice will be given by the Company to the Holders as
provided in the Indenture. To exercise a repurchase Right, a Holder must deliver
to the Trustee a written notice as provided in the Indenture.

8.   Conversion Rights.

         Subject to and upon compliance with the provisions of the Indenture,
the Holder of Securities is entitled, at such Holder's option, at any time
before the close of business on February 8, 2007, to convert the Holder's
Securities (or any portion of the principal amount hereof which is $1,000 or an
integral multiple thereof), at the principal amount thereof or of such portion,
into duly authorized, fully paid and nonassessable shares of Common Stock of the
Company at the Conversion Price in effect at the time of conversion.

         In the case of a Security (or a portion thereof) called for redemption,
such conversion right in respect of the Security (or such portion thereof) so
called, shall expire at the close of business on the second Business Day
preceding the Redemption Date, unless the Company defaults in making the payment
due upon redemption. In the case of a Change of Control for which the Holder
exercises its Repurchase Right with respect to a Security (or a portion
thereof), such conversion right in respect of the Security (or portion thereof)
shall expire at the close of business on the Business Day preceding the
Repurchase Date.

         The Conversion Price shall be initially equal to $76.71 per share of
Common Stock. The Conversion Price shall be adjusted under certain circumstances
as provided in the Indenture.

         To exercise the conversion right, the Holder must surrender the
Security (or portion thereof) duly endorsed or assigned to the Company or in
blank, at the office of the Conversion Agent, accompanied by a duly signed
conversion notice to the Company. Any Security surrendered for conversion during
the period from the close of business on any Regular Record Date to the opening
of business on the corresponding Interest Payment Date (other than any Security
whose Maturity is prior to such Interest Payment Date), shall also be
accompanied by payment in New York Clearing House funds or other funds
acceptable to the Company of an amount equal to the interest payable on such
Interest Payment Date on the principal amount of the Securities being
surrendered for conversion.

         No fractional shares of Common Stock will be issued upon conversion of
any Securities. Instead of any fractional share of Common Stock which would
otherwise be issued upon conversion of such Securities, the Company shall pay a
cash adjustment as provided in the Indenture.

9.   Subordination.

         The Indebtedness evidenced by this Security is, to the extent and in
the manner provided in the Indenture, subordinated and subject in right of
payment to the prior payment in full of all amounts then due on all Senior Debt
of the Company, and this Security is issued subject to such provisions of the
Indenture with respect thereto. Each Holder of this Security, by accepting the
same, (a) agrees to and shall be bound by such provisions, (b) authorizes and
directs the Trustee



                                      A-9
<PAGE>


on such Holder's behalf to take such action as may be necessary or appropriate
to effectuate the subordination so provided and (c) appoints the Trustee such
Holder's attorney-in-fact for any and all such purposes.

10.  Denominations; Transfer; Exchange.

         The Securities are issuable in registered form, without coupons, in
denominations of $1,000 and integral multiples of $1,000 in excess thereof. A
Holder may register the transfer or exchange of Securities in accordance with
the Indenture. The Registrar may require a Holder, among other things, to
furnish appropriate endorsements and transfer documents and the Company may
require a Holder to pay any taxes and fees required by law or permitted by the
Indenture.

         In the event of a redemption in part, the Company will not be required
(a) to register the transfer of, or exchange, Securities for a period of 15 days
immediately preceding the date notice is given identifying the serial numbers of
the Securities called for such redemption, or (b) to register the transfer of,
or exchange, any such Securities, or portion thereof, called for redemption.

         In the event of redemption, conversion or repurchase of the Securities
in part only, a new Security or Securities for the unredeemed, unconverted or
unrepurchased portion thereof will be issued in the name of the Holder hereof.

11.  Persons Deemed Owners.

         The registered Holder of this Security shall be treated as its owner
for all purposes.

12.  Unclaimed Money.

         The Trustee and the Paying Agent shall pay to the Company any money
held by them for the payment of principal, premium, if any, or interest that
remains unclaimed for two years after the date upon which such payment shall
have become due. After payment to the Company, Holders entitled to the money
must look to the Company for payment as general creditors unless an applicable
abandoned property law designates another Person, and all liability of the
Trustee and such Paying Agent with respect to such money shall cease.

13.  Discharge Prior to Redemption or Maturity.

         Subject to certain conditions contained in the Indenture, the Company
may discharge its obligations under the Securities and the Indenture if (1) (a)
all of the Outstanding Securities shall become due and payable at their
scheduled Maturity within one year or (b) all of the Outstanding Securities are
scheduled for redemption within one year, and (2) the Company shall have
deposited with the Trustee money and/or U.S. Government Obligations sufficient
to pay the principal of, and premium, if any, and interest on, all of the
Outstanding Securities on the date of Maturity or redemption, as the case may
be.



                                      A-10
<PAGE>


14.  Amendment; Supplement; Waiver.

         The Indenture permits, with certain exceptions as therein provided, the
amendment thereof and the modification of the rights and obligations of the
Company and the rights of the Holders of the Securities under the Indenture at
any time by the Company and the Trustee with the consent of the Holders of a
majority in aggregate principal amount of the Outstanding Securities (or such
lesser amount as shall have acted at a meeting pursuant to the provisions of the
Indenture). The Indenture also contains provisions permitting the Holders of
specified percentages in principal amount of the Securities at the time
Outstanding, on behalf of the Holders of all the Securities, to waive compliance
by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver
by the Holder of this Security shall be conclusive and binding upon such Holder
and upon all future Holders of this Security and of any Security issued upon
registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security or
such other Security.

         No reference herein to the Indenture and no provision of this Security
or of the Indenture shall alter or impair the obligation of the Company, which
is absolute and unconditional, to pay the principal of and premium, if any, and
interest (including Liquidated Damages, if any) on this Security at the times,
places and rate, and in the coin or currency, herein prescribed or to convert
this Security (or pay cash in lieu of conversion) as provided in the Indenture.

15.  Defaults and Remedies.

         The Indenture provides that an Event of Default with respect to the
Securities occurs when any of the following occurs:

                  (a) the Company defaults in the payment of the principal of or
         premium, if any, on any of the Securities when it becomes due and
         payable at Maturity, upon redemption or exercise of a Repurchase Right
         or otherwise, whether or not such payment is prohibited by the
         subordination provisions of Article 13 of the Indenture;

                  (b) the Company defaults in the payment of interest on any of
         the Securities when it becomes due and payable and such default
         continues for a period of 30 days, whether or not such payment is
         prohibited by the subordination provisions of Article 13 of the
         Indenture;

                  (c) the Company fails to perform or observe any other term,
         covenant or agreement contained in the Securities or the Indenture and
         such default continues for a period of 60 days after written notice of
         such failure is given as specified in the Indenture;

                  (d) (i) the Company fails to make any payment by the end of
         the applicable grace period, if any, after the maturity of any
         Indebtedness for borrowed money in an amount in excess of $5,000,000
         (provided that such failure shall not constitute an Event of Default if
         (1) the Company determines, in good faith, that a lessor under a lease
         described in clause (3)(a) of the definition of Indebtedness set forth
         in the



                                      A-11
<PAGE>


         Indenture breached a covenant under the lease and the Company has given
         notice of the breach to the lessor and the Trustee and (2) as a result
         of the breach, the Company withholds payment under the lease) (a
         "Default Exception"), or (ii) there is an acceleration of any
         Indebtedness for borrowed money in an amount in excess of $5,000,000
         because of a default with respect to such Indebtedness (other than a
         Default Exception) without such Indebtedness having been discharged or
         such acceleration having been cured, waived, rescinded or annulled, in
         the case of either clause (i) or (ii) above, for a period of 30 days
         after written notice is given to the Company as specified in the
         Indenture; and

                  (e) there are certain events of bankruptcy, insolvency or
         reorganization of the Company.

         If an Event of Default shall occur and be continuing, the principal of
all the Securities may be declared due and payable in the manner and with the
effect provided in the Indenture.

16.  Authentication.

         This Security shall not be valid until the Trustee (or authenticating
agent) executes the certificate of authentication on the other side of this
Security.

17.  Abbreviations.

         Customary abbreviations may be used in the name of a Holder or an
assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the
entireties), JT TEN (= joint tenants with right of survivorship and not as
tenants in common), CUST (= Custodian) and U/G/M/A (= Uniform Gifts to Minors
Act).

18.  Additional Rights of Holders of Transfer Restricted Securities.

         In addition to the rights provided to Holders under the Indenture,
Holders of Transfer Restricted Securities shall have all the rights set forth in
the Registration Rights Agreement.

19.  CUSIP Numbers.

         Pursuant to a recommendation promulgated by the Committee on Uniform
Security Identification Procedures, the Company has caused CUSIP numbers to be
printed on this Security and the Trustee may use CUSIP numbers in notices of
redemption as a convenience to Holders. No representation is made as to the
accuracy of such numbers either as printed on this Security or as contained in
any notice of redemption and reliance may be placed only on the other
identification numbers placed thereon.

20.  Governing Law.

         The Indenture and this Security shall be governed by, and construed in
accordance with, the law of the State of New York.



                                      A-12
<PAGE>


21.  Successor Corporation.

         In the event a successor corporation assumes all the obligations of the
Company under this Security, pursuant to the terms hereof and of the Indenture,
the Company will be released from all such obligations.



                                      A-13
<PAGE>


                                 ASSIGNMENT FORM

         To assign this Security, fill in the form below and have your signature
guaranteed: (I) or (we) assign and transfer this Security to:


- --------------------------------------------------------------------------------
                  (Insert assignee's soc. sec. or tax I.D. no.)


- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
              (Print or type assignee's name, address and zip code)

and irrevocably appoint_________________________________________________________
to transfer this Security on the books of the Company.  The agent may substitute
another to act for him.



Dated:_____________________    Your Name:
                                         ---------------------------------------
                                         (Print your name exactly as it appears
                                         on the face of this Security)


                               Your Signature:
                                              ----------------------------------
                                              (Sign exactly as your name appears
                                              on the face of this Security)


                               Signature Guarantee*:
                                                    ----------------------------










         * PARTICIPANT IN A RECOGNIZED SIGNATURE GUARANTEE MEDALLION PROGRAM (OR
OTHER SIGNATURE GUARANTOR ACCEPTABLE TO THE TRUSTEE).



                                      A-14
<PAGE>


In connection with any transfer of this Security occurring prior to the date
which is the earlier of the end of the period referred to in Rule 144(k) under
the Securities Act, the undersigned confirms that without utilizing any general
solicitation or general advertising that:

                           [Check One]

[ ] (a) this Security is being transferred in compliance with the exemption from
registration under the Securities Act of 1933, as amended, provided by Rule 144A
thereunder.

                           or

[ ] (b) this Security is being transferred other than in accordance with (a)
above and documents are being furnished which comply with the conditions of
transfer set forth in this Security and the Indenture.

If none of the foregoing boxes is checked, the Trustee or other Registrar shall
not be obligated to register this Security in the name of any Person other than
the Holder hereof unless the conditions to any such transfer of registration set
forth herein and in Sections 2.7, 2.8 and 2.9 of the Indenture shall have been
satisfied.

Dated:______________           -------------------------------------------------
                               NOTICE: The signature to this assignment must
                               correspond with the name as written upon the face
                               of the within-mentioned instrument in every
                               particular, without alteration or any change
                               whatsoever.

                               Signature Guarantee:


                               -------------------------------------------------
                               Signature must be guaranteed by a participant in
                               a recognized signature guaranty medallion program
                               or other signature guarantor acceptable to the
                               Trustee.



                                      A-15
<PAGE>


TO BE COMPLETED BY PURCHASER IF (a) ABOVE IS CHECKED.

         The undersigned represents and warrants that it is purchasing this
Security for its own account or an account with respect to which it exercises
sole investment discretion, in each case for investment and not with a view to
distribution, and that it and any such account is a "Qualified Institutional
Buyer" within the meaning of Rule 144A under the Securities Act of 1933 and is
aware that the sale to it is being made in reliance on Rule 144A and
acknowledges that it has received such information regarding the Company as the
undersigned has requested pursuant to Rule 144A or has determined not to request
such information and that it is aware that the transferor is relying upon the
undersigned's foregoing representations in order to claim the exemption from
registration provided by Rule 144A.



Dated:_________________          -----------------------------------------------
                                 NOTICE:  To be executed by an executive officer



                                      A-16
<PAGE>


                                CONVERSION NOTICE

TO:      INHALE THERAPEUTIC SYSTEMS, INC.
         150 Industrial Road
         San Carlos, California 94070

         The undersigned registered owner of this Security hereby irrevocably
exercises the option to convert this Security, or the portion hereof (which is
$1,000 principal amount or an integral multiple thereof) below designated, into
shares of Common Stock in accordance with the terms of the Indenture referred to
in this Security, and directs that the shares issuable and deliverable upon such
conversion, together with any check in payment for fractional shares and any
Securities representing any unconverted principal amount hereof, be issued and
delivered to the registered holder hereof unless a different name has been
indicated below. If shares or any portion of this Security not converted are to
be issued in the name of a person other than the undersigned, the undersigned
will pay all transfer taxes payable with respect thereto. Any amount required to
be paid to the undersigned on account of interest (including Liquidated Damages,
if any) accompanies this Security.



Dated:_____________________    Your Name:
                                         ---------------------------------------
                                         (Print your name exactly as it appears
                                         on the face of this Security)


                               Your Signature:
                                              ----------------------------------
                                              (Sign exactly as your name appears
                                              on the face of this Security)


                               Signature Guarantee*:
                                                    ----------------------------


                               Social Security or other Taxpayer
                               Identification Number:
                                                     ---------------------------


         Principal amount to be converted (if less than all):  $



         * PARTICIPANT IN A RECOGNIZED SIGNATURE GUARANTEE MEDALLION PROGRAM (OR
OTHER SIGNATURE GUARANTOR ACCEPTABLE TO THE TRUSTEE).



                                      A-17
<PAGE>


Fill in for registration of shares (if to be issued) and Securities (if to be
delivered) other than to and in the name of the registered holder:


                  ---------------------------------------------
                  (Name)


                  ---------------------------------------------
                  (Street Address)


                  ---------------------------------------------
                  (City, State and Zip Code)



                                      A-18
<PAGE>


                     NOTICE OF EXERCISE OF REPURCHASE RIGHT

TO:      INHALE THERAPEUTIC SYSTEMS, INC.
         150 Industrial Road
         San Carlos, California 94070

         The undersigned registered owner of this Security hereby irrevocably
acknowledges receipt of a notice from Inhale Therapeutic Systems, Inc. (the
"Company") as to the occurrence of a Change of Control with respect to the
Company and requests and instructs the Company to repay the entire principal
amount of this Security, or the portion thereof (which is $1,000 principal
amount or an integral multiple thereof) below designated, in accordance with the
terms of the Indenture referred to in this Security, together with interest
(including Liquidated Damages, if any) accrued and unpaid to, but excluding,
such date, to the registered holder hereof, in cash.



Dated:_____________________    Your Name:
                                         ---------------------------------------
                                         (Print your name exactly as it appears
                                         on the face of this Security)


                               Your Signature:
                                              ----------------------------------
                                              (Sign exactly as your name appears
                                              on the face of this Security)


                               Signature Guarantee*:
                                                    ----------------------------


                               Social Security or other Taxpayer
                               Identification Number:
                                                     ---------------------------


         Principal amount to be converted (if less than all):  $



         * PARTICIPANT IN A RECOGNIZED SIGNATURE GUARANTEE MEDALLION PROGRAM (OR
OTHER SIGNATURE GUARANTOR ACCEPTABLE TO THE TRUSTEE).



                                      A-19
<PAGE>


                 SCHEDULE OF EXCHANGES FOR PHYSICAL SECURITIES(2)

                 The following exchanges of a part of this Global Security for
Physical Securities have been made:

<TABLE>
<CAPTION>

Date of Exchange   Amount of decrease in        Amount of increase in       Principal Amount of this    Signature of authorized
- ----------------   Principal Amount of this   Principal Amount of this    Global Security following     of Trustee officer
                     Global Security            Global Security            such decrease (or            -----------------------
                   ------------------------   ------------------------            increase)
                                                                          --------------------------
<S>                <C>                        <C>                         <C>                           <C>

</TABLE>
















- -------------------------
(2)      This schedule should be included only if the Security is issued in
         global form.


<PAGE>
                                                                   Exhibit 10.18

                                 [LETTERHEAD]


                                    INHALE



December 6, 1999


Phillip H. Raiser
Harvey E. Chapman, Jr.
Harbor Belmont Associates
800 S. Claremont Street, Suite 201
San Mateo, CA 94402

Re:   260 Harbor Boulevard

Gentlemen:

In connection with the pending Sublease by and between Webvan Group, Inc. as
Sublessor and Inhale Therapeutic Systems, Inc. as Sublessee, for Subleased
Premises of approximately 7,985 rentable square feet located at 260 Harbor
Boulevard, said Sublease to be for the Term commencing on December 1, 1999
and ending on June 30, 2003, (capitalized terms as defined in the Sublease
and/or Master Lease), Sublessee, in order to induce Harbor Belmont Associates,
the Master Lessor, to consent to the Sublease and, specifically, to the Tenant
Improvement Plan (Exhibit B, dated December 2, 1999, to the Sublease) herewith
agrees that all Tenant Improvement work shall be performed by Raiser
Construction Co., Inc. or, at the option of Master Lessor, another general
contractor acceptable to Master Lessor.  It is further understood and agreed
that all Tenant Improvements of any kind made to the Subleased Premises
during the Term shall require obtaining applicable building permits.


SUBLESSEE:                                  MASTER LESSOR:


By:  /s/ Sharon Reiss-Miller                By:
   -------------------------------             --------------------------------
Name Printed:  SHARON REISS-MILLER          Name Printed:
             ---------------------                       ----------------------
Its:  V.P. OPERATIONS MGMT                  Its:
    ------------------------------              -------------------------------
Date:  12/7/99                              Date:
     -----------------------------               ------------------------------

<PAGE>

                                 [LETTERHEAD]



December 6, 1999



Ms. Sharon Reiss Miller
INHALE THERAPEUTIC SYSTEMS, INC.
150 Industial Road
San Carlos, CA 94070

RE: 260 HARBOR BOULEVARD
    BELMONT, CA

Dear Sharon:

Enclosed is your copy of the fully executed Sublease Agreement by and between
Webvan Group, Inc. (Sublessor) and Inhale Therapeutic Systems, Inc.
(Sublessee) for the property located at 260 Harbor Boulevard, Belmont.

We are excited to have Inhale Therapeutic Systems, Inc. as a tenant at Harbor
Park.

Sincerely,

CB RICHARD ELLIS, INC.

/s/ Bob McSweeney

Robert L. McSweeney
First Vice President


Enclosure


cc: Greg Domanico

<PAGE>






                                   SUBLEASE

                                BY AND BETWEEN

                        WEBVAN GROUP, INC. AS SUBLESSOR

                                      AND

                 INHALE THERAPEUTIC SYSTEMS, INC. AS SUBLESSEE


                             260 HARBOR BOULEVARD
                                  BELMONT, CA


                            DATED: NOVEMBER 3, 1999



Sublease
11/16/99
Page 1 of 12

<PAGE>

                               TABLE OF CONTENTS

<TABLE>
<S>                                                     <C>

RECITALS                                                  3
Section 1. Sublease.                                      3
Section 2. Warranty by Sublessor                          3
Section 3. Term.                                          4
Section 4. Rent.                                          4
Section 5. Security Deposit.                              5
Section 6. Use of Premises.                               5
Section 7. Assignment and Subletting                      6
Section 8. Other Provisions of Sublease                   6
Section 9. Hazardous Materials                            7
Section 10. Attorney Fees.                                8
Section 11. Brokers.                                      8
Section 12. Notices.                                      8
Section 13. Successors and Assigns.                       9
Section 14. Attornment.                                   9
Section 15. Entry                                         9
Section 16. Late Charge and Interest.                     9
Section 17. Master Lessor's Performance and Consent       9
Section 18. Entire Agreement.                            10
Section 19. Time of Essence.                             10
Section 20. Consent by Master Lessor                     10
Section 21. Governing Law.                               11
Section 22. Purchase of Equipment and Furniture          11
MASTER LESSOR'S CONSENT TO SUBLEASE                      11
</TABLE>

Sublease
11/16/99
Page 2 of 12


<PAGE>

THIS SUBLEASE ("SUBLEASE") dated as of November 3, 1999, is made between
WEBVAN GROUP, INC., a California corporation ("SUBLESSOR"), and INHALE
THERAPEUTIC SYSTEMS, INC., a Delaware corporation ("SUBLESSEE").

                                   RECITALS

A.  Sublessor is the lessee under "Standard Form Industrial Net Lease" dated
    as of March 20, 1998 (hereinafter, the "MASTER LEASE"), pursuant to which
    Harbor Belmont Associates, a California General Partnership ("MASTER
    LESSOR") leased to Intelligent Systems for Retail, Inc., (prior name of
    Webvan Group, Inc.), a California Corporation, the real property located
    in the City of Belmont, County of San Mateo, State of California,
    described as 260 Harbor Boulevard (the "MASTER PREMISES").

B.  The Master Lease has been amended by the following amendments: Amendment
    to Lease dated June 4, 1998; Amendment No. 2 to Lease dated
    December 4, 1998; and Amendment No. 3 to Lease dated December 31, 1998.

C.  The Master Lease, together with any amendments, are collectively referred
    to as the "MASTER LEASE."

D.  A copy of the Master Lease and all amendments thereto, with certain
    confidential information having been omitted, is attached and
    incorporated in this Sublease as Exhibit A.

                             SECTION 1. SUBLEASE.

Sublessor subleases to Sublessee on the terms and conditions in this Sublease
the following portion of the Master Premises ("SUBLEASED PREMISES"):
Approximately 7,985 rentable square feet of office / R&D space in a building
consisting of approximately 29,425 rentable square feet, which is part of a
Project consisting of 212,000 square feet, of which Sublessee's Percentage
Share is 3.77%.

In addition, Sublessee shall have the right to use all of the parking spaces
allocated to Sublessor pursuant to the original Master Lease, pursuant to the
provisions of Section 8 of the Addendum thereto

The parties hereto acknowledge that Amendments No. 2 and No. 3 to the Master
Lease added additional premises ("ADDITIONAL PREMISES") to the original
Master Premises. These Additional Premises are not included in the Subleased
Premises, nor are the terms and conditions of Amendments No. 2 or No. 3
incorporated into this Sublease.

                      SECTION 2. WARRANTY BY SUBLESSOR

Sublessor warrants to Sublessee that the Master Lease is in full force and
effect; has not been amended or modified except as expressly set forth in
this Sublease; that neither the Master Lessor nor the Sublessor is now, and
as of the commencement of the Term (defined in this Sublease) of this
Sublease will not be, in default or breach of any of the provisions of the
Master Lease; and that Sublessor has no knowledge of any claim by Master
Lessor that Sublessor is in default or breach of any of the provisions of the
Master Lease. Sublessor agrees to keep the Master Lease in effect during the
entire Term of this Sublease Agreement (subject, however, to any earlier
termination of the Master Lease which is not the fault of the Sublessor), and
to comply with and perform all of Sublessor's obligations under the Master
Lease that Sublessee is not obligated to perform as part of Sublessee's
obligations under this Sublease Agreement.




Sublease
11/16/99
Page 3 of 12


<PAGE>


                               SECTION 3. TERM.

The term of this Sublease (the "TERM") will commence on the later of December
1, 1999 ("COMMENCEMENT DATE"), or when Master Lessor consents to this
Sublease, whichever occurs later, and end on June 30, 2003 ("TERMINATION
DATE"), unless terminated sooner in accordance with the provisions of this
Sublease. If the Term commences on a date other than the Commencement Date,
Sublessor and Sublessee will execute a memorandum setting forth the actual
date of commencement of the Term. Possession of the Subleased Premises
("POSSESSION") will be delivered to Sublessee on the commencement of the
Term. If for any reason Sublessor does not deliver Possession to Sublessee on
the Commencement of the Term, Sublessor will not be subject to any liability
for this failure, the Termination Date will not be extended by the delay, and
the validity of this Sublease will not be impaired. Rent will be abated until
delivery of Possession. However, if Sublessor has not delivered Possession to
Sublessee within thirty (30) days after the Commencement Date, at any time
after that and before delivery of Possession, Sublessee may give written
notice to Sublessor of Sublessee's intention to cancel this Sublease. The
notice will set forth an effective date for the cancellation, which will be
at least ten (10) days after delivery of notice to Sublessor. If Sublessor
delivers Possession to Sublessee on or before this effective date, this
Sublease will remain in full force. If Sublessor fails to deliver Possession
to Sublessee on or before this effective date, this Sublease will be
canceled. Upon cancellation, all consideration previously paid by Sublessee
to Sublessor on account of this Sublease will be returned to Sublessee, this
Sublease will have no further force, and Sublessor will have no further
liability to Sublessee because of this delay or cancellation. If Sublessor
permits Sublessee to take Possession prior to the commencement of the Term,
the early Possession will not advance the Termination Date and will be
subject to the provisions of this Sublease, including, without limitation,
the payment of rent.

                               SECTION 4. RENT.

(a) BASE RENT. Sublessee will pay to Sublessor as Base Rent, without
    deduction, setoff, notice, or demand, at 1241 E. Hillsdale Boulevard,
    Suite 210, Foster City, CA 94404, or at any other place Sublessor
    designates by notice to Sublessee, the sum of $19,164.00 for Months
    1-12 of the Sublease, and thereafter such Base Rent as adjusted
    pursuant to subsection (b) below, in advance of the first day of each
    month of the Term. Sublessee will pay to Sublessor on execution of this
    Sublease the sum of $19,164 as Base Rent for December 1-31, 1999. If the
    Term begins or ends on a day other than the first or last day of a
    month, the Base Rent for the partial months will be prorated on a per diem
    basis.

(b) BASE RENT ADJUSTMENTS: Beginning on the first anniversary of the Sublease
    Commencement Date and on each successive anniversary thereafter during the
    Sublease Term ("ADJUSTMENT DATE"), Base Rent shall be increased by
    one-hundred percent (100%) of the percentage of increase, if any, shown by
    the Consumer Price Index for All Urban Consumers, San Francisco Bay Area,
    All Items (base years 1982-1984 = 100) ("INDEX"), published by the United
    States Department of Labor, Bureau of Labor Statistics, for the month
    immediately preceding the Adjustment Date as compared with the Index for
    the same month in the immediately preceding calendar year; provided,
    however, that Base Rent shall be increased by not less than three percent
    (3%) per year nor more than six percent (6%) per year. Sublessor shall
    calculate the amount of this increase in Base Rent after the United States
    Department of Labor publishes the statistics on which the amount of the
    increase will be based. Sublessor shall give written notice of the amount
    of the increase, multiplied by the number of installments of rent due
    under this Lease since the Adjustment Date. Sublessee shall pay this
    amount, together with the monthly rent next becoming due under this
    Sublease, and shall thereafter pay the monthly rent due under this
    Sublease at this increased rate, which shall constitute Base Rent.
    Sublessor's failure to make the required


Sublease
11/16/99
Page 4 of 12

<PAGE>


    calculations promptly shall not be considered a waiver of
    Sublessor's rights to adjust the monthly rent due, nor shall it
    affect Sublessee's obligations to pay the increased Base Rent. If
    the Index is changed so that the base year differs from that in
    effect on the Sublease Commencement Date, the Index shall be
    converted in accordance with the conversion factor published by the
    United States Department of Labor, Bureau of Labor Statistics. If
    the Index is discontinued or revised during the Sublease Term, the
    government index or computation with which it is replaced shall be
    used to obtain substantially the same result as if the Index had not
    been discontinued or revised.

(c) OPERATING COSTS. The parties acknowledge that the Master Lease
    requires Sublessor to pay to Master Lessor a portion of the expenses
    of operating the project of which the Subleased Premises are a part
    (collectively, "OPERATING COSTS"), including, but not limited to,
    taxes, utilities, or insurance. During the Term of this Sublease,
    Sublessee will pay to Sublessor as additional rent one hundred
    percent (100%) of the amounts payable by Sublessor for Operating
    Costs incurred during the Term for the Subleased Premises. This
    additional rent will be payable as and when Operating Costs are
    payable by Sublessor to Master Lessor. If the Master Lease provides
    for payment by Sublessor of Operating Costs on the basis of an
    estimate, then as and when adjustments between estimated and actual
    Operating Costs for the Subleased Premises are made under the Master
    Lease, the obligations of Sublessor and Sublessee will be adjusted
    in the same manner. If this adjustment occurs after the expiration
    or earlier termination of the Term, the obligations of Sublessor and
    Sublessee under this Subsection will survive this expiration or
    termination. Sublessor will, on request by Sublessee, furnish
    Sublessee with copies of all statements submitted by Master Lessor
    of the actual or estimated Operating Costs during the Term.

                      SECTION 5. SECURITY DEPOSIT.

Sublessee will deposit with Sublessor on execution of this Sublease the
sum of Twenty Thousand ($20,000.00) Dollars as security for Sublessee's
faithful performance of Sublessee's obligations under this Sublease
("SECURITY DEPOSIT"). If Sublessee fails to pay rent or other charges
when due under this Sublease, or fails to perform any obligations under
this Sublease, Sublessor may use any portion of the Security Deposit for
the payment of any rent or other amount then due and unpaid, for the
payment of any other sum for which Sublessor may become obligated
because of Sublessee's default or breach, or for any loss sustained by
Sublessor as a result of Sublessee's default or breach. If Sublessor
uses any portion of the Security Deposit, Sublessee will, within ten
(10) days after written demand by Sublessor, restore the Security
Deposit to the full amount originally deposited. Sublessee's failure to
do so will constitute a default under this Sublease. Sublessor will not
be required to keep the Security Deposit separate from its general
accounts, and will have no obligation or liability for payment of
interest on the Security Deposit. If Sublessor assigns its interest in
this Sublease, Sublessor will deliver to its assignee as much of the
Security Deposit as Sublessor then holds. Within ten (10) days after the
Term has expired or Sublessee has vacated the Subleased Premises or any
final adjustment pursuant to Subsection 4(b) of this Sublease has been
made, whichever occurs last, and provided that Sublessee is not then in
default under this Sublease, the Security Deposit, or as much as remains
that has not been applied by Sublessor, will be returned to Sublessee or
to the last assignee, if any, of Sublessee's interest under this
Sublease.

                     SECTION 6. USE OF PREMISES.

The Subleased Premises will be used and occupied only for office,
administration, marketing, and all related legal uses, all subject to
Master Lessor's approval; and for no other use or purpose.


Sublease
11/16/99
Page 5 of 12

<PAGE>


                     SECTION 7. ASSIGNMENT AND SUBLETTING.

Sublessee will not assign this Sublease or further sublet all or any
part of the Subleased Premises without the prior written consent of
Sublessor (and the consent of Master Lessor, if this is required under
the terms of the Master Lease).

The foregoing notwithstanding, Sublessee shall be entitled to assign or
sublease the Subleased Premises without the consent of Sublessor to any
Affiliated Company of Sublessee, meaning any corporation which controls,
is controlled by, or is under common control with Sublessee, or to any
corporation resulting from a merger or consolidation with Sublessee, or
to any person or entity which acquires all, or substantially all, of the
assets of Sublessee as a going concern, provided that any such assignee
assumes, in full, the obligations of Sublessee under this Sublease
Agreement, and provided further that Sublessee shall not be released
from its obligations under or liabilities arising out of this Sublease
Agreement.

The above provision notwithstanding, Sublessee shall be required to
secure Master Lessor's consent to any subsequent assignment or
subletting to the full extent as required under the Master Lease, whose
terms and provisions are expressly incorporated herein.

                    SECTION 8.  OTHER PROVISIONS OF SUBLEASE.

(a)  All applicable terms and conditions of the Master Lease are
     incorporated into and made a part of this Sublease as if Sublessor
     were the Lessor, Sublessee the lessee, and the Subleased Premises
     the Master Premises, except for the following:  Section 2; Section 3
     (but only to the extent that the Base Rent payable under the Master
     Lease differs from the Rent set forth herein); Section 32; Section
     38; Section 39; Addendum Sections 1-3, Section 5, Addendum Sections
     9-10; Section 11(a); Amendment No. 2 to Lease (in its entirety);
     Amendment No. 1 to Lease (except to the extent that such amendment
     extended the term of the Master Lease); and Amendment No. 3 to Lease
     (in its entirety).

(b)  Sublessee assumes and agrees to perform the Lessee's obligations
     under the Master Lease during the Term to the extent that these
     obligations are applicable to the Subleased Premises.  However, the
     obligation to pay rent and operating costs to Master Lessor under
     the Master Lease will be considered performed by Sublessee to the
     extent and in the amount rent and operating costs are paid to
     Sublessor in accordance with Section 4 of this Sublease.

(c)  Sublessee will not commit or suffer any act or omission that will
     violate any of the provisions of the Master Lease.  Sublessor will
     exercise due diligence in attempting to cause Master Lessor to
     perform its obligations under the Master Lease for the benefit of
     Sublessee.

(d)  If the Master Lease terminates, at the option of Master Lessor, this
     Sublease will terminate and the parties will be relieved of any
     further liability or obligation under this Sublease.  However, if
     the Master Lease terminates as a result of a default or breach by
     Sublessor or Sublessee under this Sublease or the Master Lease, the
     defaulting party will be liable to the nondefaulting party for the
     damage suffered as a result of the termination.  Regardless, if the
     Master Lease gives Sublessor any right to terminate the Master Lease
     in the event of the partial or total damage, destruction, or
     condemnation of the Master Premises or the building or project of
     which the Master Premises are a part, the exercise of this right by
     Sublessor will not constitute a default or breach.

(e)  If  Sublessor fails to cure any default by Sublessor in the
     performance of its obligations, covenants and agreements under this
     Sublease Agreement, including without limitation Sublessor's
     obligation to perform its obligations under the Master Lease, either
     within ten (10) days in the case


Sublease
11/16/99
Page 6 of 12

<PAGE>

     of a payment default under this Sublease Agreement or the Master
     Lease, or within thirty (30) days after written notice of such
     default from Sublessee in the case of other defaults, Sublessee
     shall have the right, but not the obligation, to cure any such
     default and to thereafter be reimbursed by Sublessor for the
     reasonable costs incurred in effecting such cure and by reason of
     such default by Sublessor.

(f)  Sublessor shall not amend or otherwise modify the Master Lease in a
     manner that would adversely affect the Subleased Premises,
     Sublessee's use or occupancy thereof (or its use of the Common
     Areas), or Sublessor's or Sublessee's rights or obligations under
     this Sublease Agreement without the prior written consent of
     Sublessee, which shall not be unreasonably withheld.

(g)  Sublessor shall provide to Sublessee, promptly upon receipt thereof,
     copies of any notices from the Master Lessor that are relevant to
     Sublessee's use or occupancy of the Subleased Premises, the conduct
     of Sublessee's business thereon, or Sublessee's rights and
     obligations under this Sublease Agreement, including without
     limitation copies of any notices stating that Sublessor is in
     default of its obligations under the Master Lease.

                     SECTION 9.  HAZARDOUS MATERIALS

(a)  USE OF HAZARDOUS MATERIAL. Sublessor has no knowledge of the
     presence of any Hazardous Material, as hereinafter defined, in, on
     or about the Subleased Premises.  Sublessee shall not cause or
     permit any Hazardous Material, to be generated, brought onto, used,
     stored, or disposed of in or about the Subleased Premises or the
     Project by Sublessee or its agents, employees, contractors,
     subtenants or invitees ("Sublessee's Hazardous Materials").
     Sublessee shall:

  (i)  Use, store, and dispose of all such Sublessee's Hazardous Material
       in strict compliance with all applicable statutes, ordinances, and
       regulations in effect during the Sublease Term that relate to
       public health and safety and protection of the environment
       ("ENVIRONMENTAL LAWS"), including but not limited to those
       Environmental Laws identified herein; and

  (ii) Comply at all times during the Sublease Term with all Environmental
       Laws applicable to Sublessee's Hazardous Materials.

(b)  INDEMNIFICATION.

  (i)  Sublessee shall, at Sublessee's sole expense and with counsel
       reasonably acceptable to Sublessor, indemnify, defend, and hold
       harmless Sublessor and Sublessor's shareholders, directors,
       officers, employees, partners, affiliates, and agents with respect
       to all losses arising out of or resulting from the release of any
       Hazardous Material in or about the Subleased Premises or the
       Building, or the violation of any Environmental Law, by Sublessee
       or Sublessee's agents, contractors, or invitees.

  (ii) Sublessor shall, at Sublessor's sole expense and with counsel
       reasonably acceptable to Sublessee, indemnify, defend and hold
       harmless Sublessee and Sublessee's shareholders, directors,
       officers, employees, partners, affiliates and agents with respect
       to all losses arising out of or resulting from any Hazardous
       Materials brought onto the Subleased Premises by or at the
       direction of Sublessor.

(c)  DEFINITION OF "HAZARDOUS MATERIAL."  As used in this Sublease, the
     term "HAZARDOUS MATERIAL" shall mean any hazardous or toxic
     substance, material, or waste that is or becomes regulated by


Sublease
11/16/99
Page 7 of 12

<PAGE>


the United States, the State of California, or any local government authority
having jurisdiction over the Building. Hazardous Material includes:

(i)    Any "hazardous substance," as that term is defined in the
       Comprehensive Environmental Response, Compensation, and Liability Act of
       1980 (CERCLA) (42 United States Code sections 9601-9675);

(ii)   "Hazardous waste," as that term is defined in the Resource Conservation
       and Recovery Act of 1976 (RCRA) (42 United States Code sections
       6901-6992k);

(iii)  Any pollutant, contaminant, or hazardous, dangerous, or toxic chemical,
       material, or substance, within the meaning of any other applicable
       federal, state, or local law, regulation, ordinance, or requirement
       (including consent decrees and administrative orders imposing liability
       or standards of conduct concerning any hazardous, dangerous, or toxic
       waste, substance, or material, now or hereafter in effect);

(iv)   Petroleum products;

(v)    Radioactive material, including any source, special nuclear,
       or byproduct material as defined in 42 United States Code
       sections 2011-2297g-4;

(vi)   Asbestos in any form or condition; and

(viii) Polychlorinated biphenyls (PCBs) and substances or compounds
       containing PCBs.

                          SECTION 10. ATTORNEY FEES.

If either party commences an action against the other in connection with this
Sublease, the prevailing party will be entitled to recover costs of suit and
reasonable attorney fees.

                             SECTION 11. BROKERS.

Sublessor and Sublessee each warrant that they have not dealt with any real
estate broker in connection with this transaction except for CB Richard Ellis,
representing Sublessor and BT Commercial, representing Sublessee. Sublessor
and Sublessee each agree to indemnify, defend, and hold the other harmless
against any damages incurred as a result of the breach of the warranty
contained in this Sublease.

                             SECTION 12. NOTICES.

All notices and demands that may be required or permitted by either party to
the other will be in writing. All notices and demands by the Sublessor to
Sublessee will be sent by United States Mail, postage prepaid, addressed to
the Sublessee at the Subleased Premises, and to the address in this Sublease
below, or to any other place that Sublessee may from time to time designate
in a notice to the Sublessor. All notices and demands by the Sublessee to
Sublessor will be sent by United States Mail, postage prepaid, addressed to
the Sublessor at the address in this Sublease, and to any other person or
place that the Sublessor may from time to time designate in a notice to the
Sublessee.

To Sublessor:
Webvan Group, Inc., 1241 E. Hillsdale Blvd., Suite 210, Foster City, CA 94404
ATTENTION: Kim Marlan


Sublease
11/16/99
Page 8 of 12

<PAGE>


To Sublessee:
Inhale Therapeutic Systems, Inc., __________________________.
ATTENTION: _______________________________________

                    SECTION 13. SUCCESSORS AND ASSIGNS.

This Sublease will be binding on and inure to the benefit of the parties to
it, their heirs, executors, administrators, successors in interest, and
assigns.

                         SECTION 14. ATTORNMENT.

If the Master Lease terminates, Sublessee will, if requested, attorn to
Master Lessor and recognize Master Lessor as Sublessor under this Sublease.
However, Sublessee's obligation to attorn to Master Lessor will be
conditioned on Sublessee's receipt of a nondisturbance agreement.

                           SECTION 15. ENTRY.

Sublessor reserves the right to enter the Subleased Premises on reasonable
notice to Sublessee to inspect the Subleased Premises or the performance by
Sublessee of the terms and conditions of this Sublease. In an emergency, no
notice will be required for entry.

                  SECTION 16. LATE CHARGE AND INTEREST.

The late payment of any Rent will cause Sublessor to incur additional costs,
including the cost to maintain in full force the Master Lease, administration
and collection costs, and processing and accounting expenses. If Sublessor
has not received any installment of Rent within five (5) days after that
amount is due, Sublessee will pay five percent (5%) of the delinquent amount,
which is agreed to represent a reasonable estimate of the cost incurred by
Sublessor. In addition, all delinquent amounts will bear interest from the
date the amount was due until paid in full at a rate per annum ("Applicable
Interest Rate") equal to the greater of (a) five percent (5%) per annum plus
the then federal discount rate on advances to member banks in effect at the
Federal Reserve Bank of San Francisco on the 25th day of the month preceding
the date of this Sublease or (b) ten percent (10%). However, in no event will
the Applicable Interest Rate exceed the maximum interest rate permitted by
law that may be charged under these circumstances. Sublessor and Sublessee
recognize that the damage Sublessor will suffer in the event of Sublessee's
failure to pay this amount is difficult to ascertain and that the late charge
and interest are the best estimate of the damage that Sublessor will suffer.
If a late charge becomes payable for any three (3) installments of Rent
within any twelve (12) month period, the Rent will automatically become
payable quarterly in advance.

              SECTION 17. MASTER LESSOR'S PERFORMANCE AND CONSENT

(a) Sublessee recognizes that Sublessor is not in a position to provide any
    of the utilities or services required or appropriate for the Building or
    the Subleased Premises or to perform any of the obligations required of
    Master Lessor by the terms of the Master Lease. To the extent that the
    provision of any services or the performance of any maintenance or any
    other act respecting the Subleased Premises or the Building is the
    responsibility of the Master Lessor, (collectively, "MASTER LESSOR
    OBLIGATIONS"), upon Sublessee's request, Sublessor shall make reasonable
    efforts to cause Master Lessor to perform such Master Lessor Obligations;
    provided, however, that in no event shall Sublessor be liable to Sublessee
    for any liability, loss or damage whatsoever in


Sublease
11/16/99
Page 9 of 12

<PAGE>


    the event that Master Lessor should fail to perform the same, nor shall
    Sublessee be entitled to withhold that payment of Rent or terminate this
    Sublease. It is expressly understood that the services and repairs which
    are incorporated herein by reference, including but not limited to the
    maintenance of exterior walls, structural portions of the roof,
    foundations, walls and floors, driveways, parking areas, and landscaping
    will in fact be furnished by Master Lessor and not by Sublessor, except to
    the extent otherwise provided in the Master Lease. In addition, Sublessor
    shall not be liable for any maintenance, restoration (following casualty
    or destruction) or repairs in or to the Building or Premises, other than
    its obligation hereunder to use reasonable efforts to cause Master Lessor
    to perform its obligations under the Master Lease. With respect to any
    maintenance or repair to be performed by Master Lessor respecting the
    Subleased Premises, the parties expressly agree that Sublessee shall have
    the right to contact Master Lessor directly to cause it to so perform.
    Except as otherwise provided herein, Sublessor shall have no other
    obligations to Sublessee with respect to the performance of Master Lessor
    Obligations.

(b) Sublessor and Sublessee recognize that certain actions Sublessee may wish
    to undertake pursuant to this Sublease Agreement will require, in addition
    to or in lieu of the consent of Sublessor, the consent of the Master
    Lessor. Whenever the consent of the Master Lessor is required under the
    Master Lease, and whenever the Master Lessor fails to perform its
    obligations under the Master Lease, Sublessor agrees to use its
    commercially reasonable, good faith efforts to obtain, at Sublessee's sole
    cost and expense, that consent or performance on behalf of Sublessee; and
    Sublessee shall cooperate with such efforts.

(c) Subject to Master Lessor's approval, as described below, Sublessor and
    Sublessee agree that Sublessee shall have the right to install tenant
    improvements in the Subleased Premises in accordance with and subject to
    the Tenant Improvement Plan attached hereto as Exhibit B (the "INITIAL
    TENANT IMPROVEMENTS") and incorporated herein by this reference. Anything
    in this Sublease Agreement to the contrary notwithstanding, it is agreed
    and understood by Sublessor and Sublessee (i) that Sublessor shall not
    impose any obligation on Sublessee to remove, at the expiration or earlier
    termination of the Sublease, the Initial Tenant Improvements, except to
    the extent that Master Lessor imposes such an obligation upon Sublessor,
    and (ii) that Sublessee's obligation to remove such tenant improvements
    shall be only that, if any, imposed by the Master Lessor in accordance
    with the Master Lease.

                         SECTION 18. ENTIRE AGREEMENT.

This Sublease sets forth all the agreements between Sublessor and Sublessee
concerning the Subleased Premises, and there are no other agreements either
oral or written other than as set forth in this Sublease.

                         SECTION 19. TIME OF ESSENCE.

Time is of the essence in this Sublease.

                     SECTION 20. CONSENT BY MASTER LESSOR.

THIS SUBLEASE WILL HAVE NO EFFECT UNLESS CONSENTED TO BY MASTER LESSOR WITHIN
10 DAYS AFTER EXECUTION IF CONSENT IS REQUIRED UNDER THE TERMS OF THE MASTER
LEASE.


Sublease
11/16/99
Page 10 of 12

<PAGE>

                         SECTION 21. GOVERNING LAW.

This Sublease will be governed by and construed in accordance with
California law.

               SECTION 22. PURCHASE OF EQUIPMENT AND FURNITURE

Sublessee shall, separate and apart from the payment of Rent, purchase
certain furniture belonging to Sublessor presently located on the Subleased
Premises, all of which are listed on attached Exhibit A, for a purchase price
of $30,000.00. Payments in the amount of $10,000 each shall be due on
December 1, 1999, January 1, 2000 and February 1, 2000. The parties expressly
understand and agree that these payments represent compensation for the
purchase of Sublessor's personal property, and do not constitute rent.

IN WITNESS WHEREOF, THE PARTIES HAVE EXECUTED THE SUBLEASE:

SUBLESSEE:                             SUBLESSOR:

By /s/Stephen L. Hurst                 By /s/ David S. Rock
  --------------------------------       -----------------------------
Name Printed: Stephen L. Hurst         Name Printed: David S. Rock
             ---------------------                  ------------------
Its: General Counsel                   Its: Vice President Real Estate
    ------------------------------         ---------------------------
Date: 23 November 1999                 Date: November 24, 1999
     -----------------------------          --------------------------

By /s/ Sharron Reiss-Muller            By
  --------------------------------       -----------------------------
Name Printed: Sharron Reiss-Muller     Name Printed:
             ---------------------                  ------------------
Its: V.P. Operations Mgmt              Its:
    ------------------------------         ---------------------------
Date:  11/23/99                        Date:
     -----------------------------          --------------------------

                     MASTER LESSOR'S CONSENT TO SUBLEASE

The undersigned ("Master Lessor"), Lessor under the Master Lease, consents to
the Sublease without waiver of any restriction in the Master Lease concerning
further assignment or subletting. Master Lessor certifies that, as of the
date of Master Lessor's execution, Sublessor is not in default or breach of
any of the provisions of the Master Lease, and that the Master Lease has not
been amended or modified except as expressly set forth in the Sublease.

Master Lessor hereby consents to the installation of the Initial Tenant
Improvements at the Subleased Premises in accordance with and subject to the
Tenant Improvement Plan attached hereto as Exhibit B and incorporated herein
by this reference. Neither Sublessor nor Sublessee shall have any obligation
to remove, at the expiration or earlier termination of the Sublease, any such
Initial Tenant Improvements.

MASTER LESSOR:

By /s/ Phillip Raiser
  --------------------------
Name Printed: Phillip Raiser
             ---------------
Its General Partner
   -------------------------
Date: 12/1/99
     -----------------------

Sublease
11/16/99
Page 11 of 12

<PAGE>

                                   EXHIBIT A
                           PERSONAL PROPERTY INVENTORY

<TABLE>
<CAPTION>
DESCRIPTION                                          QUANTITY
- -----------                                          --------
<S>                                                 <C>
Corner Desk - 36 x 36 x 25                           6
Corner Desk - 36 x 36 x 26                           3
Double Ped Return - 25 x 60                          6
Conference Reference Table - 36 x 36                 1
Conference Table - 42 x 66                           1
Solo Side Arm Chairs                                 24
Opening Bookcases - 12 x 42 x 36                     8
Round Table - 42"                                    2
Driset/Desk Mounted Bookcase - 14 x 36 x 34          2
Steelcase Locking Overhead Bookshelf - 60 x 14       1
Steelcase Panel Leg                                  1
Free Standing Return Open Shell - 24 x 48 x 29       1
Return w/b-b-f 20' w/o Ped                           2
Free Standing Return Worksurface - 30 x 25           6
Free Standing Return Worksurface - 36 x 25           1
Free Standing Return Worksurface - 25 x 42           3
Free Standing Return Worksurface - 48 x 25           4
Free Standing Return Worksurface - 6/6/12 60 x 25    2
Free Standing Return Worksurface - 60 x 25           4
Free Standing Return Worksurface - 36 x 25           7
Panel End Leg - 25"                                  2
Overhead w/lock                                      3
Wall Channel                                         6
Overhead 60" w/lock                                  1
60" Tack Board                                       3
Workstations                                         10
Work stations, conference/training area, reception

</TABLE>
PROPERTY NOT INCLUDED:
Approximately 82 Aeron Chairs


Sublease
11/16/99
Page 12 of 12

<PAGE>

                   STANDARD FORM INDUSTRIAL NET LEASE

                        BASIC LEASE INFORMATION

DATE: March 20, 1998

LESSOR: Harbor Belmont Associates, a California General Partnership

LESSEE: Intelligent Systems for Retail, Inc., a California Corporation

<TABLE>
<CAPTION>
                                                                            LEASE REFERENCE

<S>                                                                           <C>
PREMISES: 260 Harbor Boulevard, Belmont, CA                                    PARAGRAPH 1

RENTABLE AREA OF PREMISES: Seven Thousand Nine Hundred Eighty-Five sq. ft.     PARAGRAPH 1
                           (7,985 sq. ft.)
TERM COMMENCEMENT: May 15, 1998                                                PARAGRAPH 2

TERM EXPIRATION: May 31, 2003                                                  PARAGRAPH 2

TENANT IMPROVEMENT ALLOWANCE: $15,000; see addendum                            PARAGRAPH 2

BASE RENT: $1.55                                                              PARAGRAPH 3

LESSEE'S PERCENTAGE SHARE: 3.77%                                               PARAGRAPH 3

USE: Research and development, administration, office and marketing, and       PARAGRAPH 4
     all other uses as approved by the City of Belmont

SECURITY DEPOSIT: Twenty Seven Thousand Nine Hundred Forty Seven and           PARAGRAPH 32
                  00/100 Dollars ($27,947.00)

LESSEE'S ADDRESS FOR NOTICES:

1241 Hillsdale Blvd., Suite 203
- -------------------------------
Foster City, CA  94404
- -------------------------------

- -------------------------------                                                PARAGRAPH 34

LESSOR'S ADDRESS FOR NOTICES:

800 SOUTH CLAREMONT AVENUE
SAN MATEO, CA 94402                                                            PARAGRAPH 34

EXHIBIT(S) AND ADDENDUM:                                                       PARAGRAPH 41

   EXHIBIT A - DIAGRAM OF PREMISES
   Addendum to Lease

</TABLE>

THE PROVISIONS OF THE LEASE IDENTIFIED ABOVE ARE THOSE PROVISIONS WHERE
REFERENCES TO PARTICULAR BASIC LEASE INFORMATION APPEAR. EACH SUCH REFERENCE
SHALL INCORPORATE THE APPLICABLE BASIC LEASE INFORMATION. IN THE EVENT OF ANY
CONFLICT BETWEEN ANY BASIC LEASE INFORMATION AND THE LEASE, THE LATTER SHALL
CONTROL.

LESSEE: Intelligent Systems for Retail,       LESSOR: Harbor Belmont Associates,
Inc., a California Corporation                a California General Partnership

By /s/ Louis H. Borders                       By /s/ Phillip Raiser
  ------------------------------------          --------------------------------
  Louis H. Borders

Its President                                 Its General Partner
   -----------------------------------           -------------------------------

<PAGE>

                       STANDARD FORM INDUSTRIAL NET LEASE

                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                      Page
<S>                                                                  <C>
 1.  The Premises..................................................    1

 2.  Term; Initial Tenant Improvements.............................    1

 3.  Rental........................................................    1

 4.  Use...........................................................    2

 5.  Services and Utilities........................................    2

 6.  Other Taxes and Charges Payable by Lessee.....................    2

 7.  Alterations and Additions.....................................    2

 8.  Liens.........................................................    2

 9.  Maintenance and Repairs.......................................    3

10.  Destruction or Damage.........................................    3

11.  Insurance.....................................................    3

12.  Waiver of Subrogation.........................................    3

13.  Indemnification...............................................    3

14.  Compliance with Legal Requirements............................    3

15.  Assignment and Subletting.....................................    3

16.  Rules.........................................................    4

17.  Entry by Lessor...............................................    4

18.  Events of Default.............................................    4

19.  Termination Upon Default......................................    5

20.  Continuation After Default....................................    5

21.  Other Relief..................................................    5

22.  Lessor's Right to Cure Defaults...............................    5

23.  Attorneys' Fees...............................................    5

24.  Eminent Domain................................................    5

25.  Subordination.................................................    5

26.  No Merger.....................................................    5

27.  Sale..........................................................    5

28.  Estoppel Certificate..........................................    5

29.  No Light, Air, or View Easement...............................    5

30.  Holding Over..................................................    5

31.  Abandonment...................................................    5

32.  Security Deposit..............................................    5

33.  Waiver........................................................    6

34.  Notices.......................................................    6

35.  Complete Agreement............................................    6

36.  Corporate Authority...........................................    6

37.  Miscellaneous.................................................    6

38.  Limitations of Lessor's Liability.............................    6

39.  Brokerage Commissions.........................................    6

40.  Parking.......................................................    6

41.  Exhibits and Addendum.........................................    6
</TABLE>

Rules and Regulations
Exhibit(s) and Addendum

<PAGE>

                       STANDARD FORM INDUSTRIAL NET LEASE


     THIS LEASE, dated March 20, 1998 for purposes of reference only, is made
     and entered into by and between Harbor Belmont Associates, a California
     General Partnership ("Lessor") and Intelligent Systems for Retail, Inc.,
     a California Corporation ("Lessee").

1.   THE PREMISES:  Lessor hereby leases to Lessee and Lessee hereby leases
     from Lessor the premises (the "premises"), designated on the floor plan
     attached hereto as Exhibit A, comprising 7985 rentable square feet
     located in unit 260 in Building A of Harbor Park, located at 300 Harbor
     Boulevard in Belmont, California for the term and subject to the
     covenants and conditions hereinafter set forth, to each and all of which
     Lessor and Lessee hereby mutually agree.

2.   TERM; INITIAL TENANT IMPROVEMENTS:  (a)  The term of this Lease shall
     commence and, unless sooner terminated as hereinafter provided, shall
     end on the dates respectively specified in the Basic Lease information.
     If Lessor, for any reason whatsoever, cannot deliver possession of the
     premises to Lessee at the commencement of said term as above specified,
     this Lease shall not be void or voidable, nor shall Lessor be liable to
     Lessee for any loss or damage resulting therefrom, but in that event
     rental shall be waived for the period between the commencement of said
     term and the time when Lessor can deliver possession. No delay of
     possession shall operate to extend the term hereof commensurately.

     (b)  Prior to the commencement of the term, Lessee shall complete the
     Tenant improvements to be constructed or installed in the premises
     pursuant to ADDENDUM attached hereto (the "Tenant Improvements"). SEE
     ADDENDUM [ILLEGIBLE].

     (c)  Lessor shall pay the cost of the Tenant improvements up to the sum
     specified in the Basic Lease information as the Tenant Improvement
     Allowance and all other Tenant Improvement Costs shall be paid by
     Lessee, as provided in the Addendum [ILLEGIBLE].

     (d)  In the event Lessor permits Lessee to occupy the premises prior to
     the commencement date of the term, such occupancy shall be subject to
     all provisions of this Lease. See Addendum paragraph 3

3.   RENTAL:  (a) Base Rent. Lessee shall pay to Lessor throughout the term
     of the Lease as rental for the premises the sum specified in the Basic
     Lease information as the Base Rent, subject to the following adjustment:

     See Addendum paragraph 1

     (b)  LESSEE'S PERCENTAGE SHARE OF OPERATING EXPENSES AND PROPERTY TAXES.
     Lessee shall pay to Lessor throughout the term hereof as additional
     rental Lessee's Percentage Share of Operating Expenses and Property
     Taxes.

           (1)  The term "Operating Expenses" shall mean (1) all costs of
           management, operation and maintenance of the Project including,
           without limitation, wages, salaries, fringe benefits and payroll
           burden of employees, maintenance, guard, security and other
           services, Project office rent or rental value, water and waste
           disposal for the Project, janitorial services, gas, electricity
           and other utilities for the Building and Project common areas,
           materials and supplies, maintenance and repairs, landscaping,
           insurance, depreciation on personal property, and (2) the cost of
           any capital improvements made to the Project by Lessor that are
           anticipated to reduce other Operating Expenses or made to the
           Project by Lessor that are required under any governmental law or
           regulation, such cost or allocable portion thereof to be amortized
           over such reasonable period as Lessor shall determine together
           with interest on the unamortized balance at the reference rate
           from time to time announced by the Bank of America, San Francisco
           main office, plus 2% per annum or such higher rate as may have
           been paid by Lessor on funds borrowed for the purpose of
           constructing such capital improvements; provided, however, that
           Operating Expenses shall not include Property Taxes, depreciation
           on the buildings in the Project, costs of tenants' improvements in
           excess of tenant standard, real estate brokers' commissions,
           interest and capital items other than those referred to in clause
           (2) above and any expense to the extent Lessor receives direct
           reimbursement by tenants, insurers or other third parties. Actual
           Operating Expenses for calendar year shall be adjusted to equal
           Lessor's reasonable estimate of Operating Expenses had 100% of the
           rentable area of the Project been occupied.

           (2)  The term "Property Taxes" shall mean all real property taxes
           and personal property taxes, licenses, charges and assessments
           which are levied, assessed or imposed by any governmental or
           quasi-governmental authority, improvement or assessment district
           with respect to the Project or any other fixtures, improvements,
           equipment or other property of Lessor, real or personal, located
           in the Project and used in connection with the operation thereof,
           whether or not now customary or within the contemplation of the
           parties hereto, including, without limitation, any taxes, charges
           or assessments for public improvements, services or benefits,
           irrespective of when commenced or completed, transit fees, housing
           funds, education funds, street, highway or traffic fees, as well
           as any tax which shall be levied or assessed in addition to or in
           lieu of such taxes, any charge upon Lessor's business of leasing of
           the Project (unless included in paragraph 6) and any costs or
           expenses of contesting any such taxes, licenses, charges or
           assessments, but excluding any federal or state income or gift tax
           or any franchise, capital stock, estate or inheritance taxes. In
           the event that it shall not be lawful for Lessee to reimburse
           Lessor for Lessee's percentage share of any Property Tax, as
           defined herein, the rent payable to Lessor under this Lease shall
           be revised to yield to Lessor the same net rent from the premises
           after imposition of any such tax upon Lessor as would have been
           received by Lessor hereunder prior to the imposition of any such
           tax.

           (3)  The term "Lessee's Percentage Share" shall mean the
           percentage figure specified in the Basic Lease information. Lessor
           and Lessee acknowledge that Lessee's percentage share has been
           obtained by dividing the net rentable area of the premises,
           specified in the Basic Lease information, by the total net
           rentable area in the Project, which Lessor and Lessee agree is
           212,000 square feet, and multiplying such quotient by 100. In the
           event Lessor's Percentage Share is changed during a calendar
           year by reason of a change in the net rentable area of the
           premises, Lessee's Percentage Share shall thereafter mean the
           result obtained by dividing the new net rentable area of the
           premises by 212,000 square feet and multiplying such quotient by
           100, and for the purposes of section 3, Lessee's Percentage Share
           shall be determined on the basis of the number of days during such
           calendar year at each such Percentage Share.

           (4)  Prior to the commencement of the term hereof, and in December
           of each subsequent calendar year, or as soon thereafter as
           practicable, Lessor shall give Lessee written notice of its
           estimate of Lessee's Percentage Share of Operating Expenses and
           Property Taxes. On or before the first day of each month during
           the ensuing calendar year, Lessee shall pay to Lessor 1/12 of such
           estimated amounts, provided that if such notice is not given in
           December, Lessee shall continue to pay on the basis of the then
           applicable rental until the month after such notice is given. If at
           any time or times it

                                                          INDUSTRIAL NET LEASE
                                                          INITIAL HERE:

                                                          [ILLEGIBLE]
                                                          --------------------
                                                          Page 1
<PAGE>

          appears to Lessor that the amounts payable under this paragraph (b)
          for the current calendar year will vary from its estimate by more
          than 5%. Lessor may, by notice to Lessee, revise its estimate for
          such year, and subsequent payments by Lessee for such year shall be
          based upon such revised estimate.

          (5) Within 90 days after the close of each calendar year or as soon
          after such 90-day period as practicable, Lessor shall deliver to
          Lessee a statement of actual Property Taxes and Operating Expenses
          for such calendar year. If, on the basis of such statement, Lessee
          owes an amount that is less than the estimated payments for such
          calendar year previously made by Lessee, Lessor shall credit such
          excess against the next payment of rental due from Lessee
          hereunder, or, if at the end of the term hereof, if no payments are
          due from Lessee, Lessor shall pay the excess to Lessee within 30
          days after the statement is delivered. If on the basis of such
          statement Lessee owes an amount that is more than the estimated
          payments for such calendar year previously made by Lessee, Lessee
          shall pay the deficiency to Lessor within 30 days after delivery of
          the statement. The obligation of Lessor and Lessee to make the
          reconciling payments referred to in this paragraph (s) shall
          survive the termination of this Lease.  The payments to be made
          pursuant to this paragraph (b) for partial years at the beginning or
          end of the term hereof shall be prorated on the basis which the number
          of days from the commencement of such calendar year to and including
          such termination date bears to 365.

     (c)  Rental shall be paid to Lessor on or before the first day of the
     term hereof and on or before the first day of each and every successive
     calendar month thereafter during the term hereof. In the event the term
     of this Lease commences on a day other than the first day of a calendar
     month or ends on a day other than the last day of a calendar month, then
     the monthly rental for the first and last fractional months of the term
     hereof shall be appropriately prorated.

     (d)  Lessee hereby acknowledges that late payment by Lessee to Lessor of
     rent and other sums due hereunder after the expiration of any applicable
     grace period will cause Lessor to incur costs not contemplated by this
     Lease, the exact amount of which will be extremely difficult to
     ascertain. Such costs include, but are not limited to, processing and
     accounting charges, and late charges which may be imposed on Lessor by
     the terms of any mortgage or trust deed covering the premises.
     Accordingly, if any installment of rent or any other sums due from
     Lessee shall not be received by Lessor when due or if a grace period is
     applicable, prior to the expiration of the grace period, Lessee shall pay
     to Lessor a late charge equal to 6% of such overdue amount. The
     parties hereby agree that such late charge represents a fair and
     reasonable estimate of the costs Lessor will incur by reason of late
     payment by Lessee. Acceptance of such late charge by Lessor shall in no
     event constitute a waiver of Lessee's default with respect to such
     overdue amount, nor prevent Lessor from exercising any of the other
     rights and remedies available to Lessor hereunder or at law.

     (e)  Rental and all other payments to be made by Lessee hereunder shall
     be paid to Lessor without deduction or offset, in lawful money of the
     United States of America at Lessor's address for notices hereunder or to
     such other person or at such other place as Lessor may from time to time
     designate in writing.

     (f)  All sums of money or charges required to be paid by Lessee
     hereunder shall be deemed rental for the premises and may be designated
     in as such any statutory notice to pay rent or quit the premises.

4.   USE:  The premises shall be used for the purpose set forth in the Basic
     Lease information and no other and shall be continuously occupied by
     Lessee. Lessee shall not do or permit to be done in or about the
     premises, nor bring or keep or permit to be brought or kept therein,
     anything which is prohibited by or will in any way conflict with any
     law, statute, ordinance or governmental rule or regulation now in force
     or which may hereafter be enacted or promulgated, or which is prohibited
     by the standard form of fire insurance policy, or will in any way
     increase the existing rate of or affect any fire or other insurance upon
     the Building or any of its contents, or cause a cancellation of any
     insurance policy covering the Building or any part thereof or any of its
     contents. Lessee shall not do or permit anything to be done in or about
     the premises which will in any way obstruct or interfere with the rights
     of other tenants of the Building, or injure or annoy them, or use or
     allow the premises to be used for any improper, immoral, unlawful or
     objectionable purpose, nor shall Lessee cause, maintain or permit any
     nuisance in, on or about the premises or commit or suffer to be
     committed any waste in, on or about the premises.

5.   SERVICES AND UTILITIES:  Lessee shall pay for all gas, electricity,
     heat, cooling energy, telephone, janitorial service, water, waste
     disposal, refuse collection and other utility-type services furnished to
     Lessee or the premises, together with all related installation or
     connection charges or deposits. Lessor shall designate which of the
     above utilities shall be separately metered to the premises, and, as to
     such utilities, Lessee shall pay the cost of the metering and shall
     contract directly with and shall directly pay the provider of such
     services. Lessor reserves the right at any time or from time to time
     during the term of the Lease to require any of the above utilities to be
     separately metered to the premises, at Lessee's expense, or any of the
     above services to be contracted for directly by Lessee. Lessor shall
     furnish the premises with any of the above services and utilities not
     designated by Lessor for direct contracting or metering and the expense
     thereof shall be included in Operating Expenses, of which Lessee shall
     pay its Percentage Share pursuant to paragraph 3(b), provided that
     Lessee shall promptly reimburse Lessor upon demand for the cost of such
     utilities or services used on the premises in excess of the average
     level of such services consumed by other tenants of the Building or the
     Project. Lessor shall not be liable in damages, consequential or
     otherwise, nor shall there be any rent abatement, arising out of any
     interruption whatsoever in utility services which is due to fire,
     accident, strike, governmental authority, acts of God, or other causes
     beyond the reasonable control of Lessor or any temporary interruption
     in such service which is necessary to the making of alterations,
     repairs, or improvements to Building or the Project or any part of it.

6.   OTHER TAXES AND CHARGES PAYABLE BY LESSEE: In addition to the monthly
     rental and other charges to be paid by Lessee hereunder. Lessee shall
     pay or reimburse Lessor for any and all of the following, whether or not
     now customary or in the contemplation of the parties hereto: taxes
     (other than local, state and federal personal or corporate income taxes
     measured by the net income of Lessor from all sources), assessments
     (including, without limitation, all assessments for public improvements,
     services or benefits, irrespective of when commenced or completed),
     excises, levies, business taxes, license, permit, inspection and other
     authorization fees, transit development fees, assessments or charges for
     housing funds, service payments in lieu of taxes and any other fees or
     charges of any kind, which are levied, assessed, confirmed or imposed by
     any public authority: (a) upon, measured by or reasonably attributable to
     the cost or value of Lessee's equipment, furniture, fixtures and other
     personal property located in the premises or by the cost of any leasehold
     improvements made in or to the premises by or  for Lessee, regardless of
     whether title to such improvements shall be in Lessee or Lessor; (b) upon
     or measured by the monthly rental or other charges payable hereunder,
     including, without limitation, any gross income tax or excise tax levied
     by the City and County of San Francisco, the State of California, the
     Federal Government or any other governmental body with respect to the
     receipt of such rental; (c) upon, with respect to or by reason of the
     development, possession, leasing, operation, management, maintenance,
     alteration, repair, use or occupancy by Lessee of the premises or any
     portion thereof; (d) upon this transaction or any document to which
     Lessee is a party creating or transferring an interest or an estate in the
     premises. In the event that it shall not be lawful for Lessee so to
     reimburse Lessor, the monthly rental payable to Lessor under this Lease
     shall be revised to net Lessor the same net rental after imposition of
     any such tax or other charge upon Lessor as would have been payable to
     Lessor prior to the imposition of any such tax or other charge.

7.   ALTERATIONS AND ADDITIONS:  Lessee shall not make or suffer to be made
     any alterations, additions or improvements to or of the premises or any
     part thereof or attach any fixtures to the premises without first
     obtaining the written consent of Lessor. Any alterations, additions or
     improvements to the premises, including, but not limited to, wall
     covering, paneling and built-in cabinet work, (but excepting movable
     furniture and trade fixtures, which may be removed at the end of the
     Lease term provided their removal will not cause material damage to the
     premises and the Lessee posts reasonable security with Lessor to pay for
     any repair costs caused by such removal) shall, on the expiration of the
     term, become a part of the realty and belong to Lessor and shall be
     surrendered with the premises. Lessee shall submit detailed
     specifications and floor plans and necessary permits (if applicable)
     with respect to any requested alterations or improvements to Lessor for
     review. Lessor may require reasonable changes to such specifications or
     plans as a condition to giving its consent. In no event shall any
     alterations or improvements affect the structure of the Building or its
     facade. Any work consented to by Lessor hereunder shall be done at
     Lessee's expense and shall be performed either by Lessor a contractor or
     by contractors approved by Lessor, as Lessor may elect. In addition, as
     a condition to its consent, Lessor shall be entitled to request
     adequate assurance that all contractors who will perform such work have
     in force workmen's compensation and such other employee and public
     liability insurance as Lessor deems necessary to supplement the
     insurance coverage provided below. In case of material alterations,
     additions, improvements, Lessor may require Lessee or its contractors to
     post adequate completion and performance bonds.

8.   LIENS: Lessee shall keep the premises and the Building free from any
     liens arising out of any work performed, materials furnished or
     obligations incurred by Lessee. Lessor shall have the right to post and
     keep posted on the premises any notices that may be provided by law or
     which Lessor may deem to be proper for the protection of Lessor, the
     premises and the Building from such liens.

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9.   MAINTENANCE AND REPAIRS: See Addendum, paragraph 4 Lessee shall, at all
     times during the term hereof and at Lessee's sole cost and expense, keep
     the premises and every part thereof in good condition and repair, ordinary
     wear and tear, damage thereto by fire, earthquake, act of God or the
     elements excepted, Lessee hereby waiving all rights to make repairs at the
     expense of Lessor or in lieu thereof to vacate the premises as provided by
     California Civil Code Section 1942 or any other law, statute or
     ordinance now or hereafter in effect. Lessee shall at the end of the
     term hereof surrender to Lessor the premises and all alterations,
     additions and improvements thereto in the same condition as when
     received, ordinary wear and tear and damage by fire, earthquake, act of
     God or the elements excepted. Lessor has no obligation and has made no
     promise to alter, remodel, improve, repair, decorate or paint the
     premises or any part thereof, except as specifically herein set forth.
     No representations respecting the condition of the premises or the
     Building have been made by Lessor to Lessee, except as specifically
     herein set forth.

     Lessor shall have the right to require Lessee to replace, or reimburse
     Lessor for replacement of, all plate glass, including windows, in or
     upon the premises or in the Building which may be damaged or broken by
     Lessee, its employees, agents, guests or invitees.

     (b) Lessor shall maintain the roof, exterior walls and foundation of the
     Building, driveways, parking areas and landscaping for exterior common
     areas in the Project, in reasonably good order and condition except for
     damaged caused by the act of Lessee, its agents, employees, guests, or
     invitees, which damage shall be repaired at Lessee's expense by Lessor
     or Lessee, as Lessor may elect.

10.  DESTRUCTION OR DAMAGE: (a) In the event the premises or the portion of
     the Building necessary for Lessee's occupancy are damaged by fire,
     earthquake, act of God, the elements or other casualty, Lessor shall
     forthwith repair the same, subject to the provisions of this section
     hereinafter set forth, if such repairs can, in Lessor's opinion, be made
     within 90 days and if insurance proceeds are available to pay the cost
     thereof. This Lease shall remain in full force and effect except that,
     if such damage is not the result of the negligence or willful misconduct
     of Lessee or Lessee's employees or invitees, an abatement of rental
     shall be allowed Lessee for such part of the premises as shall be
     rendered unusable by Lessee in the conduct of its business during the
     time such part is so unusable. See Addendum, paragraph 6

     (b) If such repairs cannot, in Lessor's opinion, be made within 90 days,
     or if sufficient insurance proceeds are unavailable, Lessor may elect,
     upon notice to Lessee within 30 days after the date of such fire or
     other casualty, to repair or restore such damage, in which event this
     Lease shall continue in full force and effect, but the rent shall be
     partially abated as hereinabove in this section provided. If Lessor does
     not so elect to make such repairs, this Lease shall terminate as of the
     date of such fire or other casualty.

     (c) A total destruction of the Building shall automatically terminate
     this Lease. Lessee waives California Civil Code Sections 1932(2) and
     1933(4) providing for termination of hiring upon destruction of the
     thing hired.

     (d) If the premises are to be repaired under this section, Lessor shall
     repair at its cost any injury or damage to the Building itself and all
     leasehold improvements in the premises other than tenant improvements
     made by or for Lessee. Lessee shall pay the cost of repairing any tenant
     improvements made by or for Lessee and the cost of repairs or replacing
     Lessee's fixtures and personal property in the premises.

11.  INSURANCE: Lessee shall obtain and maintain during the term of this
     Lease comprehensive general liability insurance with a combined single
     limit for personal injury and property damage in an amount not less than
     $1,000,000, and employer's liability and worker's compensation insurance
     as required by law. If Lessee's insurance contains a split limit of
     liability the liability limit shall be not less than $1,000,000 for
     bodily injury and $300,000 for property damage. Such insurance policy
     shall also specifically cover Lessee's indemnity obligations set forth
     in paragraph 13. Lessee's comprehensive general liability insurance
     policy shall (1) provide that (i) it may not be cancelled or altered in
     such a manner as adversely to affect the coverage afforded thereby
     without 30 days' prior written notice to Lessor, (ii) Lessor is named as
     additional insured, (iii) such insurance is primary with respect to
     Lessor and any entity managing the Building and that any other insurance
     maintained by Lessor or such management company is excess and
     noncontributing with such insurance, (2) contain a cross-liability
     endorsement or a severability of interest clause (3) contain a waiver of
     subrogation as provided in paragraph 12; (4) provide for blanket
     contractual coverage, broad form property damage coverage and products
     completed operations coverage (where applicable); and (6) afford
     coverage for all claims based on acts, omissions, injury or damage which
     occurred or arose (or the onset of which occurred or arose) in whole
     or in part during the policy period. Lessee shall insure the full
     replacement cost of all personal property and fixtures of tenant and all
     improvements made by or for tenant to the premises. All insurance to be
     provided by Lessee shall be provided by a carrier or carriers rated
     "A-ix" in Best's Insurance Guide or shall otherwise be satisfactory to
     Lessor. If, in the opinion of Lessor's insurance advisor, based on a
     substantial increase in recovered liability claims generally, the
     specified amounts of coverage are no longer adequate, such coverage
     shall be appropriately increased. Prior to the commencement of the term,
     a duplicate of such policy or a certificate thereof shall be delivered to
     Lessor for retention by it. If Lessee fails to obtain such insurance or to
     furnish Lessor any such duplicate policy or certificate as herein required,
     Lessor may, at its election, without notice to Lessee and without any
     obligation so to do, procure and maintain such coverage and Lessee shall
     reimburse Lessor on demand as additional rent for any premium so paid by
     Lessor. See Addendum, paragraph 10

12.  WAIVER OF SUBROGATION: To the extent of insurance proceeds received with
     respect to the loss, Lessor and Lessee each hereby waive any right of
     recovery against the other party for any loss or damage maintained by
     such other party with respect to the Building or the premises or any
     portion thereof or any contents thereof or any operation therein whether
     or not such loss is caused by the fault or negligence of such
     other party. Lessee and Lessor shall each obtain from its insurers under
     all policies of insurance maintained by it at any time during the term
     hereof in connection with Building, the premises, the contents or
     operations therein, a waiver of all rights of subrogation which the
     insurer of one party might have against the other party.

13.  INDEMNIFICATION: Lessee shall hold Lessor harmless from any damage to
     any property or injury to or death of any person arising from the
     use of the premises or the Building by Lessee, its agents, employees,
     contractors and invitees, except such as is caused solely by the gross
     negligence or willful act of Lessor. The foregoing indemnity obligation
     of Lessee shall include reasonable attorneys' fees, investigation costs
     and all other reasonable costs and expenses incurred by Lessor from the
     first notice that any claim or demand is to be made or may be made. The
     provisions of this section 13 shall survive the termination of this
     Lease with respect to any damage, injury or death occurring prior to
     such termination.

14.  COMPLIANCE WITH LEGAL REQUIREMENTS: Lessee shall at its sole cost and
     expense promptly comply with all laws, statutes, ordinances and
     governmental rules, regulations or requirements now in force or which
     may hereafter be in force, with the requirements of any board of fire
     underwriters or other similar body now or hereafter constituted, with
     any direction or occupancy certificate issued pursuant to any law by any
     public officer or officers, as well as the provisions of all recorded
     documents affecting the premises, insofar as any thereof relate to or
     affect the condition, use or occupancy of the premises.

15.  ASSIGNMENT AND SUBLETTING: (a) Lessee shall not, without the prior written
     consent of Lessor, assign this Lease or any interest herein, sublet the
     premises or any part thereof, permit the use or occupancy of the
     premises by any person other than Lessee, or hypothecate this Lease or
     any interest herein. Any of the foregoing acts without such consent
     shall be void and shall, at the option of Lessor, constitute a
     default that shall entitle Lessor to terminate this Lease. This Lease
     shall not, nor shall any interest herein, be assignable as to the interest
     of Lessee involuntarily or by operation of law without the prior written
     consent of Lessor. Any transfer of more than 50% of Lessee's stock, or
     of a majority of general partnership interests in Lessee shall
     constitute a prohibited assignment under this Section 15. See Addendum,
     paragraph 11.

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     (c) Lessor's consent to a proposed assignment or sublet shall not be
     unreasonably withheld.  Without limiting the other instances in which it
     may be reasonable for Lessor to withhold its consent to an assignment or
     subletting.  Lessor and Lessee acknowledge that it shall be reasonable
     for Lessor to withhold its consent in the following instances:

          (1) the proposed assignee or sublessee is a governmental agency;

          (2) in Lessor's reasonable judgment, the use of the premises by the
          proposed assignee or sublessee would entail any alterations which
          would lessen the value of the leasehold improvements in the premises,
          or would require increased services by Lessor;

          (3) in Lessor's reasonable judgment, the financial worth of the
          proposed assignee or sublessee does not meet the credit standards
          applied by Lessor for other tenants under leases with comparable
          terms;

          (4) in Lessor's reasonable judgment the character, reputation or
          business of the proposed assignee or sublessee is not consistent with
          the quality of the other tenancies in the Building or the Project;

          (5) Lessor has received from any prior lessor to the proposed assignee
          or subtenant a negative report concerning such prior lessor's
          experience with the proposed assignee or subtenant;

          (6) Lessor has experienced previous defaults by or is in litigation
          with the proposed assignee or subtenant;

          (7) in Lessor's reasonable judgment, the premises, or the relevant
          part thereof, will be used in a manner that will violate any negative
          covenant as to use contained in any other lease of space in the
          Building or the Project;

          (8) the used of the premises by the proposed assignee or subtenant
          will violate any applicable law, ordinance or regulation;

          (9) the proposed assignment or sublease will create a vacancy
          elsewhere in the Building or the Project;

          (11) the proposed assignment or sublease fails to include all of the
          terms and provisions required to be included therein pursuant to this
          paragraph 15;

          (12) Lessee is in default of any obligation of Lessee under this
          lease, or Lessee has defaulted under this Lease on three (3) or more
          occasions during the twelve (12) months preceding the date that
          Lessee shall request consent; or

          (13) in the case of a subletting of less than the entire premises, if
          the subletting would result in the division of the premises into more
          than two subparcels or would require access to be provided through
          space leased or held for lease to another tenant or improvements to
          be made outside of the premises.

     (d) In the case of an assignment one half of any sums or other economic
     consideration received by Lessor as compensation for its leasehold interest
     as a result of such assignment shall be paid to Lessor after first
     deducting the unamortized cost of leasehold improvements paid for by
     Lessee, and the cost of any real estate commissions incurred in connection
     with such assignment.  In the case of a subletting one half of any sum or
     economic consideration received by Lessee as compensation for its leasehold
     interest as a result of such subletting shall be paid to Lessor after first
     deducting (1) the rental due hereunder, prorated to reflect only rental
     allocable to the sublet portion of the premises, and (2) the cost of any
     real estate commissions incurred in connection with such subletting,
     amortized over the term of the sublease.  Upon Lessor's request Lessee
     shall assign to Lessor one half of all amounts to be paid to Lessee by any
     such subtenant or assignee and shall direct such subtenant or assignee to
     pay the same directly to Lessor.

     (e) Lessee agrees that the instrument by which any assignment or subletting
     consented to by Lessor is accomplished shall expressly provide that the
     assignee or subtenant will perform and observe all the agreements,
     covenants, conditions and provisions to be performed and observed by Lessee
     under this Lease as and when performance and observance is due, that no
     assignee or subtenant shall have the further right to assign or sublet, and
     that Lessor shall have the right to enforce such agreements, covenants,
     conditions and provisions directly against such assignee or subtenant.
     Consent by Lessor to an assignment or subletting shall not release Lessee
     from any of Lessee's obligations hereunder and shall not be deemed to be a
     consent to any subsequent transfer, assignment or subletting.  Lessee shall
     in all cases remain responsible for the performance by any subtenant or
     assignee as indicated thereon of all such agreements, covenants, conditions
     and provisions.  Any assignment or subletting without an instrument
     containing the foregoing provision shall be void and shall, at the option
     of Lessor, constitute a default that entitles Lessor to terminate this
     Lease.

     (f) In the event Lessee shall assign or sublet the premises or request the
     consent of Lessor to any assignment or subletting then Lessee shall pay
     Lessor's reasonable attorney's fees incurred in connection therewith.

16.  RULES:  Lessee shall faithfully observe and comply with the rules and
     regulations annexed to this Lease and, after notice thereof, all reasonable
     modifications thereof and additions thereto from time to time promulgated
     in writing by Lessor, Lessor shall not be responsible to Lessee for the
     nonperformance by any other tenant or occupant of the Building of any said
     rules and regulations.

17.  ENTRY BY LESSOR:  Lessor may enter the premises at reasonable hours and
     (except in emergencies) upon 24 hours prior notice to (a) inspect the same,
     (b) exhibit the same to prospective purchases, lenders or tenants, (c)
     determine whether Lessee is complying with all its obligations hereunder,
     (d) supply janitor service and any other service to be provided by Lessor
     to Lessee hereunder, (e) post notices of nonresponsibility, and (f) make
     repairs required of Lessor under the terms hereof or repairs to any
     adjoining space or utility services or make repairs, alterations or
     improvements to any other portion of the Building; provided, however, that
     all such work shall be done as promptly as reasonably possible and so as
     to cause as little interference to Lessee as reasonably possible.  Lessee
     hereby waives any claims for damages for any injury or inconvenience to or
     interference with Lessee's business, any loss of occupancy or quiet
     enjoyment of the premises or any other loss occasioned by such entry.
     Lessor shall at all times have and retain a key with which to unlock all
     of the doors in, on or about the premises (excluding Lessee's vaults, sales
     and similar areas designated in writing by Lessee in advance); and Lessor
     shall have the right to use any and all means which Lessor may deem proper
     to open said doors in an emergency in order to obtain entry to the
     premises, and any entry to the premises obtained by Lessor by any of said
     means, or otherwise, shall not under any circumstances be construed or
     deemed to be a forcible or unlawful entry into or a detainer of the
     premises or as eviction, actual or constructive, of Lessee from the
     premises, or any portion thereof.

18.  EVENTS OF DEFAULT:  The occurrence of any one or more of the following
     events ("Events of Default") shall constitute a breach of this Lease by
     Lessee:  (a) if Lessee shall fail to pay any rental when and as the same
     becomes due and payable; or (b) if Lessee shall fail to pay any other sum
     when and as the same becomes due and payable and such failure shall
     continue for more that 10 days; or (c) if Lessee shall fail to perform or
     observe any other term hereof or of the rules and regulations described in
     section 16 to be performed or observed by Lessee, such failure shall
     continue for more than 30 days after notice therefore from Lessor, and
     Lessee shall not within such period commence with due diligence and
     dispatch the curing of such default, or, having so commenced, shall
     thereafter fail or neglect to prosecute or complete with due diligence
     and dispatch the curing of such default; (d) if Lessee shall make a
     general assignment for the benefit of creditors, shall become insolvent
     or shall admit in writing its inability to pay its debts as they become
     due or shall file a petition in bankruptcy, or shall be adjudicated as
     bankrupt or insolvent, or shall file a petition in any proceeding seeking
     any reorganization, arrangement, composition, readjustment, liquidation,
     dissolution or similar relief under any present or future statute, law or
     regulation, or shall file an answer admitting or fail timely to contest
     the material allegations of a petition filed against it in any such
     proceeding, or shall seek or consent to or acquiesce in the appointment of
     any trustee, receiver or liquidator of Lessee or any material part of its
     properties; or (e) if within 90 days after the commencement of any
     proceeding against Lessee seeking any reorganization, arrangement,
     composition, readjustment, liquidation, dissolution or similar relief
     under any present or future statute, law or regulation, such proceeding
     shall not have been dismissed, or if, within 90 days after the appointment
     without the consent is acquiescence of Lessee, of any trustee, receiver
     or liquidator of Lessee or of any material part of its properties, such
     appointment shall not have been vacated; or (f) if this Lease or any
     estate of Lessee hereunder shall be levied upon under any attachment
     or execution and such attachment or execution is not vacated within 10
     days.


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19.  TERMINATION UPON DEFAULT: (a) If an Event of Default shall occur, Lessor
     at any time thereafter may give a written termination notice to Lessee,
     and on the date specified in such notice Lessee's right to possession
     shall terminate and this Lease shall terminate, unless on or before
     such date all arrears of rental and all other sums payable by Lessee
     under this Lease and all costs and expenses incurred by or on behalf of
     Lessor hereunder shall have been paid by Lessee and all other breaches
     of this Lease by Lessee at the time existing shall have been fully
     remedied to the satisfaction of Lessor. Upon such termination, Lessor
     may recover from Lessee: (a) the worth at the time of award of the
     unpaid rental which had been earned at the time of termination; (b) the
     worth at the time of award of the amount by which the unpaid rental
     which would have been earned after termination until the time of award
     exceeds the amount of such rental loss that Lessee proves could have
     been reasonably avoided; (c) the worth at the time of award of the
     amount by which the unpaid rental for the balance of the term of this
     Lease after the time of award exceeds the amount of such rental loss
     that Lessee proves could be reasonably avoided; and (d) any other amount
     necessary to compensate Lessor for all the detriment proximately caused
     by Lessee's failure to perform its obligations under this Lease or which
     in the ordinary course of things would be likely to result therefrom.
     The "worth at the time of award" of the amounts referred to in clauses
     (a) and (b) above is computed by allowing interest at the rate of 10%
     per annum or, if a higher rate is legally permissible, at the highest
     rate legally permitted. The "worth at the time of award" of the amount
     referred to in clause (c) above is computed by discounting such amount
     at the discount rate of the Federal Reserve Bank of San Francisco at the
     time of award plus 1%.

     (b) Lessee hereby waives all right now or hereafter existing to redeem
     the premises after termination pursuant to this Paragraph 19 or by order
     or judgment of any court or by any legal process.

20.  CONTINUATION AFTER DEFAULT: Even though Lessee has breached this Lease
     and abandoned the premises, this Lease shall continue in effect for so
     long as Lessor does not terminate Lessee's right to possession, and
     Lessor may enforce all its rights and remedies under this Lease,
     including the right to recover the rental as it becomes due under this
     Lease. Acts of maintenance or preservation or efforts to relet the
     premises or the appointment of a receiver upon initiative of Lessor to
     protect Lessor's interest under this Lease shall not constitute a
     termination of Lessee's right to possession.

21.  OTHER RELIEF: The remedies provided for in this Lease shall be
     cumulative and are in addition to any other remedies available to Lessor
     at law or in equity by statute or otherwise.

22.  LESSOR'S RIGHT TO CURE DEFAULTS. All agreements and provisions to be
     performed by Lessee under any of the terms of this Lease shall be at its
     sole cost and expense and without any abatement of rental. If Lessee
     shall fail to pay any sum of money, other than rental, required to be
     paid by it hereunder or shall fail to perform any other act on its part
     to be performed hereunder and such failure shall continue for 30 days
     after notice thereof by Lessor, Lessor may, but shall not be obligated
     so to do, and without waiving or releasing Lessee from any obligations
     of Lessee, make any such payment or perform any such other act on
     Lessee's part to be made or performed as in this Lease provided. All
     sums so paid by Lessor and all necessary incidental costs shall be
     deemed additional rent hereunder and shall be payable to Lessor on
     demand, and Lessor shall have (in addition to any other right or remedy
     of Lessor) the same rights and remedies in the event of the nonpayment
     thereof by Lessee as in the case of default by Lessee in the payment of
     rental.

23.  ATTORNEYS' FEES: If as a result of any breach or default in the
     performance of any of the provisions of this Lease, Lessor uses the
     services of an attorney in order to secure compliance with such
     provisions or recover damages therefor, or to terminate this Lease or
     evict Lessee, Lessee shall reimburse Lessor upon demand for any and all
     attorneys' fees and expenses so incurred by Lessor, provided that if
     Lessee shall be the prevailing party in any legal action brought by
     Lessor against Lessee, Lessee shall be entitled to recover for the fees
     of its attorneys in such amount as the court may adjudge reasonable.

24.  EMINENT DOMAIN: If all or any part of the premises shall be taken as a
     result of the exercise of the power of eminent domain, this Lease shall
     terminate as to the part so taken as of the date of taking, and, in the
     case of a partial taking, either Lessor or Lessee shall have the right
     to terminate this Lease as to the balance of the premises by written
     notice to the other within 30 days after such date, provided, however,
     that a condition to the exercise by Lessee of such right to terminate
     shall be that the portion of the premises taken shall be of such extent
     and nature as substantially to handicap, impede or impair Lessee's use
     of the balance of the premises. In the event of any taking, Lessor shall
     be entitled to any and all compensation, damages, income, rent, awards,
     or any interest therein whatsoever which may be paid or made in
     connection therewith, and Lessee shall have no claim against Lessor for
     the value of any unexpired term of this Lease or otherwise. In the event
     of a partial taking of the premises which does not result in a
     termination of this Lease, the monthly rental thereafter to be paid
     shall be equitably reduced.

25.  SUBORDINATION: This Lease shall be subject and subordinated at all times
     to (1) all ground or underlying leases now existing or which may
     hereafter be executed affecting the Building, and (2) the lien of all
     mortgages and deeds of trust in any amount or amounts whatsoever now or
     hereafter placed on or against the Building, the Project or on or
     against Lessor's interest or estate therein or on or against all such
     ground or underlying leases, all without the necessity of having further
     instruments executed on the part of Lessee to effectuate such
     subordination. Lessee agrees to execute and deliver upon demand such
     further instruments evidencing such subordination of this Lease to said
     deed, to such ground or underlying leases, and to the lien of any such
     mortgages or deeds of trust as may reasonably be required by Lessor.

26.  NO MERGER: The voluntary or other surrender of this Lease by Lessee, or
     a mutual cancellation thereof, shall not work a merger, and shall, at
     the option of Lessor terminate all or any existing subleases or
     subtenancies, or may, at the option of Lessor, operate as an assignment
     to it of any or all such subleases or subtenancies.

27.  SALE: In the event the original Lessor hereunder, or any successor owner
     of the Building, shall sell or convey the Building, all liabilities and
     obligations on the part of the original Lessor, or such successor owner,
     under this Lease accruing thereafter shall terminate, and thereupon all
     such liabilities and obligations shall be binding upon the new owner.
     Lessee agrees to attorn to such new owner.

28.  ESTOPPEL CERTIFICATE: At any time and from time to time but on not less
     than 10 days prior written request by Lessor, Lessee will execute,
     acknowledge and deliver to Lessor, promptly upon request, a certificate
     certifying (a) that this Lease is unmodified and in full force and
     effect (or, if there have been modifications, that this Lease is in full
     force and effect, as modified, and stating the date and nature of each
     modification), (b) the date, if any, to which rental and other sums
     payable hereunder have been paid, (c) that no notice has been received
     by Lessee of any default which has not been cured, except as to defaults
     specified in said certificate, and (d) such other matters as may be
     reasonably requested by Lessor. Any such certificates may be relied upon
     by a prospective purchaser, mortgagee or beneficiary under any deed of
     trust on the Building or any part thereof.

29.  NO LIGHT, AIR OR VIEW EASEMENT: Any diminution or shutting off of light,
     air or view by any structure which may be erected on lands adjacent to
     the Building shall in no way affect this Lease or impose any liability
     on Lessor.

30.  HOLDING OVER: If, without objection by Lessor, Lessee holds possession
     of the premises after expiration of the term of this Lease, Lessee shall
     become a tenant from month to month upon the terms herein specified but
     at a monthly rental equivalent to 200% of the then prevailing monthly
     rental paid by Lessee at the expiration of the term of this Lease,
     payable in advance on or before the first day of each month. Each party
     shall give the other notice at least one month prior to the date of
     termination of such monthly tenancy of its intention to terminate such
     tenancy.

31.  ABANDONMENT: If Lessee shall abandon or surrender the premises, or be
     dispossessed by process of law or otherwise, any personal property
     belonging to Lessee and left on the premises shall be deemed to be
     abandoned, at the option of Lessor, except such property as may be
     mortgaged to Lessor.

32.  SECURITY DEPOSIT: Lessee has deposited with Lessor the sum specified in
     the Basic Lease information (the "deposit"). The deposit shall be held
     by Lessor as security for the faithful performance by Lessee of all of
     the provisions of this Lease to be performed or observed by Lessee. If
     Lessee fails to pay rent or other charges due hereunder, or otherwise
     defaults with respect to any provision of this Lease, Lessor may use,
     apply or retain all or any portion of the deposit for the payment of any
     rent or other charge in default or for the payment of any other sum to
     which Lessor may become obligated by reason of Lessee a default, or to
     compensate Lessor for any loss or damage which Lessor may suffer
     thereby. If Lessor so uses or applies all or any portion of the deposit,
     Lessee shall within 10 days after demand therefor deposit cash with
     Lessor in an amount sufficient to restore the deposit to the full amount
     thereof and Lessee's failure to do so shall be a material breach of this
     Lease. Lessor shall not be required to keep the deposit separate from
     its general accounts. If Lessee performs all of Lessee's obligations
     hereunder, the deposit, or so much thereof as has not theretofore been
     applied by Lessor, shall be returned, without payment of interest or
     other increment for its use, to Lessee (or, at Lessor's option, to the
     last assignee, if any, of Lessee's interest


                                                          INDUSTRIAL NET LEASE
                                                          INITIAL HERE:

                                                          [ILLEGIBLE]
                                                          --------------------
                                                          Page 5

<PAGE>


     hereunder) at the expiration of the term hereof, and after Lessee has
     vacated the premises.  No trust relationship is created herein between
     Lessor and Lessee with respect to the deposit.

33.  WAIVER:  The waiver by Lessor of any agreement, condition or provision
     herein contained shall not be deemed to be a waiver of any subsequent
     breach of the same or any other agreement, condition or provision
     herein contained, nor shall any custom or practice which may grow up
     between the parties in the administration of the terms hereof be
     construed to waive or to lessen the right of Lessor to insist upon the
     performance by Lessee in strict accordance with said terms.  The
     subsequent acceptance of rental hereunder by Lessor shall not be deemed
     to be a waiver of any preceding breach by Lessee of any agreement,
     condition or provision of this Lease, other than the failure of Lessee to
     pay the particular rental so accepted, regardless of Lessor's knowledge
     of such preceding breach at the time of acceptance of such rental.

34.  NOTICES:  All notices and demands which may be or are required to be
     given by either party to the other hereunder shall be in writing and
     shall be deemed to have been fully given when deposited in the United
     States mail, certified or registered, postage prepaid, and addressed as
     follows: to Lessee at the address specified in the Basic Lease
     Information, or to such other place as Lessee may from time to time
     designate in a notice to Lessor: to Lessor at the address secified in
     the Basic Lease information, or to such other place as Lessor may from
     time to time designate in a notice to Lessee; or, in the case of Lessee,
     delivered to Lessee at the premises.  Lessee hereby appoints as its agent
     to receive the service of all dispossessory or distraint proceedings and
     notices thereunder the person in charge of or occupying the premises at
     the time, and, if no person shall be in charge of or occupying the same,
     then such service may be made by attaching the same on the main entrance
     of the premises.

35.  COMPLETE AGREEMENT:  There are no oral agreements between Lessor and
     Lessee affecting this Lease, and this Lease supersedes and cancels any
     and all previous negotiations, arrangements, brochures, agreements and
     understandings, if any, between Lessor and Lessee or displayed by Lessor
     to Lessee with respect to the subject matter of this Lease or the
     Building.  There are no representations between Lessor and Lessee other
     than those contained in this Lease and all reliance with respect to any
     representations is solely upon such representations.

36.  CORPORATE AUTHORITY:  If Lessee signs as a corporation, each of the
     persons executing this Lease on behalf of Lessee does hereby convenant
     and warrant that Lessee is a duly authorized and existing corporation,
     that Lessee has and is qualified to do business in California, that the
     Corporation has full right and authority to enter into this Lease, and that
     each and both of the persons signing on behalf of the corporation were
     authorized to do so.

37.  MISCELLANEOUS:  The words "Lessor" and "Lessee" as used herein shall
     include the plural as well as the singular.  If there be more than one
     Lessee, the obligations hereunder imposed upon Lessee shall be joint and
     several. Time is of the essence of this Lease and each and all of its
     provisions. Submission of this instrument for examination or signature by
     Lessee does not constitute a reservation of or option for lease, and it is
     not effective as a lease or otherwise until execution and delivery by both
     Lessor and Lessee.  The agreements, conditions and provisions herein
     contained shall, subject to the provisions as to assignment, apply to and
     bind the heirs, executors, administrators, successors and assigns of the
     parties hereto.  If any provision of this Lease shall be determined to
     be illegal or unenforceable, such determination shall not affect any other
     provision of this Lease and all such other provisions shall remain in full
     force and effect.  This Lease shall be governed by and construed pursuant
     to the laws or the State of California.

38.  LIMITATIONS OF LESSOR'S LIABILITY:  Lessor shall not be responsible for
     or liable to Lessee ane Lessee hereby waives all claims against Lessor
     for any injury, loss or damage to any person or property in or about the
     premises by or from any cause whatsoever (other than Lessor's gross
     negligence or willful misconduct) including, without limitation, acts or
     omissions of persons occupying adjoining premises or any part of the
     Building adjacent to or connected with the premises; theft; burst,
     stopped or leaking water, gas, sewer or steam pipes; or gas, fire, oil
     or electricity in, on or about the premises or the Building.  The
     liability of Lessor under this Lease shall be and is hereby limited to
     Lessor's interest in the Building, and no other assets of Lessor shall be
     affected by reason of any liability which Lessor may have to Lessee or to
     any other person by reason of this Lease.

39.  BROKERAGE COMMISSIONS:  Lessee represents and warrants that it has dealt
     with no broker, agent or other person in connection with this transaction
     other than CB COMMERCIAL REAL ESTATE GROUP, INC and Lessee agrees to
     indemnify and hold Lessor harmless from and against any claims by any
     other broker, agent or other person claiming a commission or other form
     of compensation by virtue of having dealt with Lessee with regard to
     this leasing transaction. The provisions of this paragraph shall survive
     the termination of this Lease.

40.  PARKING:  Lessee shall have the non-exclusive right to park in common
     with other tenants in the Project in the Project parking facilities
     provided by Lessor for tenants subject to Lessor's right to alter,
     modify, reduce or change the location of such parking facilities.  Lessee
     agrees not to overburden the parking facilities and agrees to cooperate
     with Lessor and other lessees in the use of the parking facilities.
     Lessor reserves the right to determine whether the parking facilities are
     becoming crowded and, in such event, to allocate parking spaces among
     Lessee and other lessees or to otherwise limit the number of parking
     spaces available for use by Lessee and its employees and invitees.
     SEE ADDENDUM, PARAGRAPH 8.

41.  EXHIBITS AND ADDENDUM:  The exhibits and addendums hereto are a part of
     this Lease and are incorporated herein by this reference.

     IN WITNESS WHEREOF, the parties have executed this Lease as of the date
     first written above.

     LESSEE:  Intelligent Systems for       LESSOR:  Harbor Belmont Associates,
     Retail, Inc., a California             a California General Partnership
     corporation

     By /s/ Louis H. Borders                By /s/ Phillip Raisen
       ------------------------------         ---------------------------------
            Louis H. Borders

       Its   President/CEO                    Its    General Partner
          ---------------------------             -----------------------------

42.  Lessor will furnish each Lessee free of charge with two (2) keys to
     each door lock in the premises.  Lessor shall require payment of a $10.00
     ($5.00 of which is refundable upon return of keys) deposit for each key
     provided to Lessee.  No Lessee shall have any keys made.  No Lessee shall
     alter any lock or install a new or additional lock or any bolt on any
     door of its premises without the prior written consent of Lessor.  Lessee
     shall in each case furnish Lessor with a key for any such lock.  Each
     Lessee, upon the termination of its tenancy, shall deliver to Lessor all
     keys to doors in the building which shall have been furnished to Lessee.


                                                          INDUSTRIAL NET LEASE
                                                          INITIAL HERE:

                                                          [ILLEGIBLE]
                                                          --------------------
                                                          Page 6

<PAGE>


                               ADDENDUM TO LEASE
                                    BETWEEN
                     HARBOR BELMONT ASSOCIATES, AS LESSOR,
                                      AND
                INTELLIGENT SYSTEMS FOR RETAIL, INC., AS LESSEE
                   260 HARBOR BOULEVARD, BELMONT, CALIFORNIA


          1.     BASE RENT SCHEDULE. Lessee shall pay to Lessor base monthly
rental according to the following schedule:

     Months 01-12          $   per sq. ft. NNN          $   00 per month
     Months 13-24          $   per sq. ft. NNN          $   00 per month
     Months 25-36          $   per sq. ft. NNN          $   00 per month
     Months 37-48          $   per sq. ft. NNN          $   00 per month
     Months 49-60          $   per sq. ft. NNN          $   00 per month

          2.     CURRENT ESTIMATE OF OPERATING EXPENSES AND PROPERTY TAXES.
Lessor and Lessee acknowledge and agree that Lessee's estimated Percentage
Share of Operating Expenses and Property Taxes for calendar year 1998 is
20 CENTS per square foot per month, based on Lessor's current estimate of
such Operating Expenses and Property Taxes, provided that Lessee and Lessor
acknowledge that such amount is an estimate only, and is subject to change in
accordance with the terms of paragraph 3 of the Lease.

          3.     EARLY OCCUPANCY. Lessee shall be entitled to occupy the
Premises prior to the Commencement Date upon mutual execution and delivery of
the Lease, subject to the provisions of paragraph 2(d) of the Lease;
provided, however, that during such period of occupancy prior to the
Commencement Date, no Base Rent, or Lessee's Percentage Share of Operating
Expenses and Property Taxes shall be due or payable by Lessee. Without
limiting the provisions of paragraph 2(d) of the Lease, Lessee acknowledges
that it shall be responsible for the cost of gas, electricity, and any other
utilities metered separately to its Premises, and for the maintenance of
insurance in accordance with the requirements of the Lease during the early
occupancy period.

         4.      CONDITION OF PREMISES. Lessor, at its sole expense, shall
deliver the Premises to Lessee clean and free of debris on the Commencement
Date (other than any condition caused by Lessee in connection with its early
occupancy of the Premises).

                 (a)     Lessor warrants to Lessee that, as of the
Commencement Date, all of the fixtures and equipment in the men's and women's
restrooms are complete and operable, and in good and working condition,
including without


                                      -1-
<PAGE>


limitation, all exhaust and supply HVAC, lighting, water heaters, partitions,
doors and fixtures;

                 (b)     Lessor further warrants to Lessee that all
electrical, HVAC, plumbing, fire sprinkler, and lighting equipment and
equipment, fixtures and systems, and loading doors, if any, existing in the
Premises as of the date of this Lease, shall be in good operating condition
as of the Commencement Date, and shall not be subject to deferred maintenance
or in need of immediate replacement.

                 (c)     If non-compliance with any of the warranties set
forth above exists as of the Commencement Date, then Lessor shall, except as
otherwise provided in the Lease, rectify the same at Lessor's expense,
promptly after receipt of written notice from Lessee setting forth with
specificity the nature and extent of such non-compliance. Notwithstanding
the foregoing, if Lessee does not give Lessor written notice of
non-compliance with any of the warranties set forth above within sixty (60)
days after the Commencement Date, then the above warranties shall be of no
force and effect, and correction of any such noncompliance shall be the
obligation of Lessee at Lessee's sole cost and expense. Notwithstanding
anything to the contrary above, Lessor shall have no obligation for any
failure of the above warranties due to the acts of Lessee, its agents,
employees or contractors.

          5.     INITIAL TENANT IMPROVEMENTS.

                 (a)     Lessor shall provide Lessee with a $15,000.00 tenant
improvement allowance (the "Tenant Improvement Allowance"). All additional
costs of tenant improvements shall be paid by Lessee. All tenant improvement
work shall be made in accordance with paragraph 7 of the Lease, provided that
all such improvement work shall be performed by Lessor's contractor, Raiser
Construction Company. Lessee shall enter into a general construction contract
with Raiser Construction Company on terms to be mutually agreed by Lessee and
Raiser Construction Company. Lessor agrees that Raiser Construction Company
shall solicit competitive bids from subcontractors for all major trades, and
shall disclose all such bid to Lessee. The Tenant Improvement Allowance
shall be paid to Raiser Construction Company upon completion of the tenant
improvements in reduction of the sum owed by Lessee to Raiser Construction
Company under its construction contract.

                 (b)     Notwithstanding any other provision of the Lease to
the contrary, Lessee shall not be required to remove its initial tenant
improvements from the Premises at the expiration or termination of the Lease,
and such improvements shall become the sole property of Lessor.


                                      -2-
<PAGE>


          6.     DESTRUCTION OR DAMAGE. Paragraph 10 of the Lease is modified
by the addition of the following provision at the end of subparagraph (b):

          If such repairs cannot, in Lessor's reasonable opinion, be
          made within 180 days after the date of such fire or other
          casualty, then Lessor shall notify Lessee, and Lessee shall
          have the right, by notice given to Lessor within 30 days
          after receipt of Lessor's notice, to terminate this Lease
          effective as of the date of such fire or other casualty.

          7.     SIGNAGE. Lessor shall allow, at Lessee's sole cost and
expense, the installation of signage on the Building consistent with Harbor
Park's current signage program and subject to the approval of Lessor and the
City of Belmont.

          8.     PARKING.

                 (a)     Lessee shall have a total of nineteen (19) reserved
parking stalls free of additional charge throughout the term of this Lease.
Thirteen (13) of said spaces shall face Harbor Boulevard, three (3) shall be
located at the front entrance of the Premises, and three (3) shall be near
the back roll-up doors. Lessor shall, at its sole cost and expense, have such
space as marked for Lessee's exclusive use.

                 (b)     In addition to the parking spaces set forth in
Subparagraph (a) above, Lessee shall be entitled to the nonexclusive use in
common with other tenants of the Property of five (5) unreserved parking
spaces in the Harbor Park parking area.

          9.     ADDITIONAL DEPOSIT. In addition to the Security Deposit
described in the Basic Lease Information, Lessee shall, upon execution of
this Lease, deliver to Lessor the additional sum of $49,348.00 in cash as
additional security for this Lease (the "Additional Deposit"). Provided that
Lessee is not in default and has met all of its obligations under the Lease,
Lessor shall apply said Additional Deposit to the rental obligations coming
due in the beginning of the second, thirteenth, twenty-fifth and
thirty-seventh month of the Lease Term.

          10.    LESSOR'S INSURANCE. Lessor shall maintain throughout the
term of this Lease casualty insurance with respect to the Premises in an
amount and with coverages at least equivalent to insurance customarily
carried by comparable owners of comparable industrial property in the City of
Belmont, California, provided that in no event shall Lessor be required to
carry earthquake or flood insurance. Lessor's costs in connection with
such insurance are included in the Operating Expenses as set forth in
paragraph 3(b) of the Lease.


                                      -3-

<PAGE>


          11.    ASSIGNMENT AND SUBLETTING.

                 (a)     Notwithstanding the provisions of paragraphs 15(a)
through (c) of the Lease, Lessee shall have the right, without the consent
of Lessor, to assign the Lease to a franchisee of Lessee, or any entity
controlled by or under common control with the Lessee, or to a corporation
with which Lessee has merged or consolidated. In such event the provisions
of paragraphs 15(a) through (d) of the Lease shall not apply. Any such
assignment shall conform to the provisions of paragraphs (d) and (f) of the
Lease, and Lessee shall notify Lessor of such assignment prior to the
execution thereof, and shall deliver to Lessor a copy of such assignment
and any other documents evidencing such assignment. In the event of any
assignment contemplated hereby, Lessee shall remain fully liable for all
obligations of Lessee under the Lease.

                 (b)     Paragraph 15(b) of the Lease is hereby amended in
its entirety to read as follows:

                 "(b)    Before entering into any sublease or
          assignment of this Lease for all or part of the premises,
          Lessee shall deliver to Lessor a letter of intent executed by
          Lessee and the proposed sublessee or assignee, specifying
          the terms of the intended sublease or assignment. For a
          period of thirty (30) days after such letter of intent is
          delivered to Lessor, Lessor shall have the right by written
          notice to Lessee to recapture the premises or port[illegible]
          there of, as fol[illegible] (1) in the case of a proposed
          sublease, either (A) sublet from Lessee any portion of the
          premises proposed to be sublet for the term for which such
          portion is proposed to be sublet but at the same rent as
          Lessee is required to pay to Lessor under this Lease for
          the same space, computed on a pro-rata square foot basis, or
          (B) if the proposed subletting is for substantially the
          remaining period of the term of this Lease, terminate this
          Lease as it pertains to the portion of the premises so
          proposed by Lessee to be sublet, or (ii) in the case of a
          proposed assignment, terminate this Lease. Lessor may, if
          it elects, enter into a new lease covering the recaptured
          premises or portion thereof with any intended assignee or
          subtenant on such terms as Lessor and such person may agree,
          or enter into a new lease covering the premises or a portion
          thereof with any other person. In the event that Lessor
          exercises its rights to recapture set forth herein, Lessee
          shall not be entitled to any portion of the profit, if any,
          which Lessor may realize on account of such recapture,
          termination and


                                      -4-
<PAGE>


          reletting; however, Lessee shall be entitled to recover from
          Lessor the unamortized actual costs of all Initial Tenant
          Improvements (less the Tenant Improvements Allowance),
          as well as any additional permanent improvements installed
          by Lessee during the initial one hundred twenty (120) days
          of the Lease. Lessor's exercise of its aforesaid option
          shall not be construed to impose any liability upon
          Lessor with respect to any real estate brokerage
          commissions or any other costs or expenses incurred by
          Lessee in connection with its proposed subletting or
          assignment."

          12.    WARRANTY OF AUTHORITY. Each individual executing this Lease
on behalf of Lessor and Lessee represents and warrants that he or she is
authorized to execute and deliver this Lease on its behalf, and to bind said
Lessor and Lessee, as applicable.


                                      -5-
<PAGE>

                             HARBOR PARK, BELMONT

                                 [FLOOR PLAN]







                                260 HARBOR BLVD.

                                   EXHIBIT A


<PAGE>


                          AMENDMENT NO. ONE TO LEASE

                      INTELLIGENT SYSTEMS FOR RETAIL, INC.


This Amendment, dated June 4, 1998, is by and between Harbor Belmont
Associates ("Lessor") and Intelligent Systems for Retail, Inc. ("Lessee").
Lessor and Lessee entered into a lease agreement dated March 20, 1998 (the
"Lease") for the Premises known as 260 Harbor Boulevard, Belmont, California.
Such Lease is hereby amended as follows:

LEASE COMMENCEMENT DATE:      June 15, 1998

LEASE TERMINATION DATE:       June 30, 2003

COST OF IMPROVEMENTS:

It is hereby agreed that the total cost of the Initial Tenant Improvements
shall be $287,207.00 according to the estimate from Raiser Construction Co.,
Inc. dated May 29, 1998. Lessee's net cost for the Initial Tenant
Improvements is $272,207.00 after the deduction of Lessor's Tenant
Improvement Allowance of $15,000.00.

Simultaneously with the execution of this Amendment No. One to Lease, Lessee
shall deposit the sum of $99,999.04 with Raiser Construction Co., Inc., which
amount shall be credited against the contract for the Initial Tenant
Improvements as earned during the course of construction. All other terms and
conditions of the Lease shall remain unchanged.


AGREED & ACCEPTED:

LESSOR: Harbor Belmont Associates  LESSEE: Intelligent Systems for Retail, Inc.

/s/ Phillip [illegible]                 /s/ David A. [illegible]
- -----------------------                 ------------------------
AS AGENT FOR THE TRUST,                 Vice President, Retail
GENERAL PARTNER

Date: 6/4/98                            Date: 6/4/84
      ------                                  ------


<PAGE>

                          AMENDMENT NO. TWO TO LEASE
                    HARBOR BELMONT ASSOCIATES AS LESSOR AND
               INTELLIGENT SYSTEMS FOR RETAIL, INC. AS LESSEE

                              PROPERTY ADDRESS
                    260 HARBOR BOULEVARD, BELMONT, CALIFORNIA
               AMENDMENT DATE (FOR REFERENCE PURPOSES): DECEMBER 4, 1998

This Amendment is incorporated into and made a part of that certain lease
dated March 20, 1998 as described above, as amended by Amendment No. 1 to
Lease dated June 4, 1998 (collectively, the "Lease").  In the event of any
conflict between the terms of the lease and the terms of this Amendment, the
terms of this Amendment shall prevail, as to the Additional Premises only. All
capitalized terms not otherwise defined herein shall have the meaning set forth
in the Lease.

1.  ADDITIONAL PREMISES: Lessee hereby leases from Lessor, and Lessor leases
    to Lessee, as Additional Premises, those premises located at 498 Harbor
    Boulevard in Belmont, California (the "Additional Premises") designated
    on the floor plan attached hereto as Exhibit B, comprising 2,475 rentable
    square feet.  The provisions of this Lease Amendment apply only to the
    Additional Premises.  No terms or conditions of this Second Addendum shall
    be deemed to alter or affect the original terms of the Lease, except as
    the same apply to the Additional Premises and except as expressly set forth
    herein.

2.  TERM APPLICABLE TO ADDITIONAL PREMISES ONLY:  The Term of the lease of
    the Additional Premises shall commence on December 1, 1998 (the
    "Additional Premises Commencement Date") and, unless sooner terminated as
    provided in the Lease, shall end on November 30, 2000 (the "Additional
    Premises Termination Date").

3.  BASE RENTAL SCHEDULE APPLICABLE TO ADDITIONAL PREMISES ONLY:  Lessee
    shall pay as monthly Base Rent for the Additional Premises the following
    sums:

      Months 1-12:     $    per sq. ft NNN -  $       per month
      Months 13-24:    $    per sq. ft NNN -  $       per month

4.  EARLY OCCUPANCY:  Lessee shall be entitled to occupy the Additional
    Premises prior to the Commencement Date upon mutual execution and
    delivery of this Lease Amendment, subject to the provisions of paragraph
    3 of the Addendum to Lease.

5.  CONDITION OF PREMISES; WARRANTIES:  Lessor shall deliver the Premise to
    Lessee clean and free of debris on the Commencement Date, in good and
    operating condition and repair as more fully set forth in paragraph 4 of
    the Addendum to Lease.  Except as expressly set forth in this paragraph
    5, Lessee accepts the Premises "as is," and  Lessor has no obligation to
    repair, alter or improve the Additional Premises.

Addendum to Lease
Rev. 12/02/98
Page 1 of 2
<PAGE>

6.  INITIAL TENANT IMPROVEMENTS:  Lessee shall construct its Initial Tenant
    Improvements for the Additional Premises, consisting of HVAC and other
    non-structural improvements, at Lessee's sole cost and expense, subject
    to Lessor's prior written approval thereof, which shall not be
    unreasonably withheld or delayed.  Lessor shall provide no tenant
    improvement allowance for the Additional Premises. Lessee may construct
    its Initial Tenant Improvements utilizing licensed contractors and
    subcontractors selected by Lessee and approved by Lessor.  Such work shall
    comply with section 7 of the Lease.

7.  PARKING:  During the term of this lease of the Additional Premises,
    Lessee shall have the use of an additional 3 reserved and 10 nonreserved
    parking spaces at no additional cost.

8.  OTHER TERMS AND CONDITIONS:  Except as set forth herein, each and every
    other term and condition of the Lease and the Addendum thereto applies to
    the Additional Premises, as if set forth fully herein; provided, however,
    that any warranties, rights or obligations that accrue to either party
    shall, for purposes of this Amendment and with respect to the Additional
    Premises only, accrue on the Additional Premises Commencement Date set
    forth above, and shall terminate with respect to the Additional Premises
    on the Additional Premises Termination Date (except with respect to any
    obligations under the Lease that expressly survive the termination of the
    Lease).

9.  LESSEE'S PERCENTAGE SHARE:  The Lease is hereby amended, effective
    during the Term for the Additional Premises only, as follows:  Lessee's
    Percentage Share under the Lease (for both the original and the
    Additional Premises) shall be 4.93%.

10. SECURITY DEPOSIT:  Lessee shall deliver a security deposit of    upon
    execution of this Amendment.

LESSEE:                                  LESSOR:
INTELLIGENT SYSTEMS FOR RETAIL, INC., a  HARBOR BELMONT ASSOCIATES, a California
California corporation                   General Partnership



By /s/ Louis H. Borders                  By /s/ Philip Raiser
  -------------------------------          -----------------------------------
  Louis H. Borders                         Philip Raiser
Its President                            Its General Partner


Addendum to Lease
Rev. 12/02/98
Page 2 of 2
<PAGE>


                                   EXHIBIT B

                                  [FLOOR PLAN]


<PAGE>


                                   EXHIBIT "C"
                               EXISTING FLOOR PLAN

                                  [FLOOR PLAN]


<PAGE>

                        AMENDMENT NO. THREE TO LEASE
                  HARBOR BELMONT ASSOCIATES AS LESSOR AND
               INTELLIGENT SYSTEMS FOR RETAIL, INC. AS LESSEE

                             PROPERTY ADDRESS
                  260 HARBOR BOULEVARD, BELMONT, CALIFORNIA
          Amendment Date (for reference purposes):  December 31, 1998

This Amendment is incorporated into and made a part of that certain lease
dated March 20, 1998 as described above, as amended by Amendment No. 1 to
Lease dated June 4, 1998 and Amendment No. 2 to Lease dated December 4, 1998
(collectively, the "Lease"). In the event of any conflict between the terms
of the lease and the terms of the Amendments, the terms of this Amendment
shall prevail, as to the Additional Premises only. All capitalized terms not
otherwise defined herein shall have the meaning set forth in the Lease.

1.   ADDITIONAL PREMISES:  Lessee hereby leases from Lessor, and Lessor
     leases to Lessee, as Additional Premises, those premises located at 288
     Harbor Boulevard in Belmont, California (the "Additional Premises")
     designated on the floor plan attached hereto as Exhibit B, comprising
     1,375 rentable square feet. The provisions of this Lease Amendment apply
     only to the Additional Premises. No terms or conditions of this Amendment
     No. 3 shall be deemed to alter or affect the original terms of the
     Lease, except as the same apply to the Additional Premises and except as
     expressly set forth herein.

2.   TERM APPLICABLE TO ADDITIONAL PREMISES ONLY:  The Term of the lease of
     the Additional Premises shall commence on January 15, 1999 (the
     "Additional Premises Commencement Date") and, unless sooner terminated
     as provided in the Lease, shall end on January 31, 2002 (the "Additional
     Premises Termination Date").

3.   BASE RENTAL SCHEDULE APPLICABLE TO ADDITIONAL PREMISES ONLY:  Lessee
     shall pay as monthly Base Rent for the Additional Premises the following
     sums:

<TABLE>
<S>                                                <C>
           January 15 - 31, 1999                    _______ Total
           February 1999 - January 2000             _______ Per Month
           February 2000 - January 2001             _______ Per Month
           February 2001 - January 2002             _______ Per Month
</TABLE>

4.   EARLY OCCUPANCY:  Lessee shall be entitled to occupy the Additional
     Premises prior to the Commencement Date upon mutual execution and
     delivery of this Lease Amendment, subject to the provisions of paragraph
     3 of the Addendum to Lease.

5.   CONDITION OF PREMISES; WARRANTIES:  Lessor shall deliver the Premises to
     Lessee clean and free of debris on the Commencement Date, in good and
     operating condition and repair as more fully set forth in paragraph 4 of
     the Addendum to Lease. Except as expressly set forth in this

                                                                 INITIAL

                                                               [ILLEGIBLE]

Addendum to Lease
Rev. 12/20/98
Page 1 of 2
<PAGE>

     paragraph 5. Lessee accepts the Premises "as is," and Lessor has no
     obligation to repair, alter or improve the Additional Premises.

6.   INITIAL TENANT IMPROVEMENTS:  Lessee shall construct its Initial Tenant
     Improvements for the Additional Premises, at Lessee's sole cost and
     expense, subject to Lessor's prior WRITTEN approval thereof, which shall
     not be unreasonably withheld or delayed. Lessor shall provide no tenant
     improvement allowance for the Additional Premises. Lessee may construct
     its Initial Tenant Improvements utilizing licensed contractors and
     subcontractors selected by Lessee and approved by Lessor, in writing.
     Such work shall comply with section 7 of the Lease. All work involving
     wall changes, electrical, fire sprinklers and HVAC shall have a building
     permit.

7.   PARKING:  During the term of this lease of the Additional Premises,
     Lessee shall have the use of an additional 2 reserved parking spaces at
     no additional cost.

8.   OTHER TERMS AND CONDITIONS:  Except as set forth herein, each and every
     other term and condition of the Lease and the Addendum thereto applies
     to the Additional Premises, as if set forth fully herein; provided,
     however, that any warranties, rights or obligations that accrue to
     either party shall, for purposes of the Amendment and with respect to
     the Additional Premises only, accrue on the Additional Premises
     Commencement Date set forth above, and shall terminate with respect to
     the Additional Premises on the Additional Premises Termination Date
     (except with respect to any obligations under the Lease that expressly
     survive the termination of the Lease).

9.   LESSEE'S PERCENTAGE SHARE:  The Lease is hereby amended, effective
     during the Terms for the Additional Premises only, as follows: Lessee's
     Percentage Share under the Lease (for both the original and the
     Additional Premises) shall be 5.58%.

10.  SECURITY DEPOSIT:  Lessee shall deliver a security deposit of $2,118.00
     upon execution of this Amendment.

LESSEE                                    LESSOR:
INTELLIGENT SYSTEMS FOR RETAIL, INC.,     HARBOR BELMONT ASSOCIATES,
a California corporation                  a California General Partnership


By /s/ Louis H. Borders                   By /s/ Phillip Raiser
   -----------------------------------       -----------------------------------
   Louis H. Borders                          Phillip Raiser
Its President                             Its General Partner


                                                                   INITIAL

                                                                 [ILLEGIBLE]

Addendum to Lease
Rev. 12/20/98
Page 2 of 2

<PAGE>




                                  [FLOORPLAN]






LEASE EXHIBIT A

INITIAL

LHB/PR
                                                        HARBOR PARK
                                                        BUILDING 'D' - STE. 288
                                                        HARBOR BOULEVARD
1,375 SQ. FT.                                           BELMONT, CA.


<PAGE>
                                                                    EXHIBIT 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

    We consent to the incorporation by reference in the Registration Statement
(Form S-8 No. 333-07969, Form S-8 No. 333-59735, Form S-8 No. 333-65919 and Form
S-8 No. 333-74669) pertaining to the Employee Stock Purchase Plan, the 1994
Equity Incentive Stock Option Plan, the Non-Employee Directors Stock Option
Plan, the 1994 Equity Incentive Plan and the 1998 Non-Officer Equity Incentive
Plan of Inhale Therapeutic Systems, Inc., the Registration Statement, (Form S-3
No. 333-20787) and related Prospectus of Inhale Therapeutic Systems, Inc. for
the registration of 1,800,000 shares of its common stock, the Registration
Statement (Form S-3 No. 333-68897) and related Prospectus of Inhale Therapeutic
Systems, Inc. for the registration of 1,200,000 shares of its common stock and
the Registration Statement (Form S-3/A No. 333-94161) and related Prospectus of
Inhale Therapeutic Systems, Inc. for the registration of 3,388,268 shares of its
common stock and $108,450,000 of 6.75% Convertible Subordinated Debentures due
October 13, 2006, of our report dated January 24, 2000, with respect to the
financial statements of Inhale Therapeutic Systems, Inc. included in this Annual
Report on Form 10-K for the year ended December 31, 1999.

/s/ Ernst & Young

Palo Alto, California
March 9, 2000

<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                           ---------------------------

                                    FORM T-1

              Statement of Eligibility and Qualification Under the
                  Trust Indenture Act of 1939 of a Corporation
                          Designated to Act as Trustee

                             -----------------------

    CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO
                             SECTION 305(B)(2)____

                            -------------------------

                     CHASE MANHATTAN BANK AND TRUST COMPANY,
                              NATIONAL ASSOCIATION
               (Exact name of trustee as specified in its charter)

                                   95-4655078
                      (I.R.S. Employer Identification No.)

                        101 California Street Suite #2725
                            San Francisco, California
                    (Address of principal executive offices)

                                      94111
                                   (Zip Code)

                               ------------------

                        INHALE THERAPEUTIC SYSTEMS, INC.
               (Exact name of Obligor as specified in its charter)

                                    Delaware
         (State or other jurisdiction of incorporation or organization)

                                   94-3134940
                      (I.R.S. Employer Identification No.)

                               150 Industrial Road
                             San Carlos, California
                    (Address of principal executive offices)

                                   94070-6256
                                   (Zip Code)

                        --------------------------------

                   5% Convertible Subordinated Notes due 2007
                         (Title of Indenture securities)


<PAGE>

ITEM 1. GENERAL INFORMATION.

                 Furnish the following information as to the trustee:

         (a)     Name and address of each examining or supervising authority to
                 which it is subject.

                 Comptroller of the Currency, Washington, D.C.
                 Board of Governors of the Federal Reserve System,
                 Washington, D.C.

         (b)     Whether it is authorized to exercise corporate trust powers.

                 Yes.

ITEM 2. AFFILIATIONS WITH OBLIGOR.

        If the Obligor is an affiliate of the trustee, describe each such
affiliation.

        (a)      Title of securities outstanding under each such other
             indenture. $108,450,000 Convertible Subordinated Debentures due
             2006 issued under Indenture dated as of October 13, 1999

ITEM 16.    LIST OF EXHIBITS.

       List below all exhibits filed as part of this statement of eligibility.

       Exhibit 1.    Articles of Association of the Trustee as Now in Effect
                     (see Exhibit 1 to Form T-1 filed in connection with
                     Registration Statement No. 333-41329, which is incorporated
                     by reference).

       Exhibit 2.    Certificate of Authority of the Trustee to Commence
                     Business (see Exhibit 2 to Form T-1 filed in connection
                     with Registration Statement No. 333-41329, which is
                     incorporated by reference).

       Exhibit 3.    Authorization of the Trustee to Exercise Corporate Trust
                     Powers (contained in Exhibit 2).

       Exhibit 4.    Existing By-Laws of the Trustee (see Exhibit 4 to Form
                     T-1 filed in connection with Registration Statement No.
                     333-41329, which is incorporated by reference).

       Exhibit 5.    Not Applicable

       Exhibit 6.    The consent of the Trustee required by Section 321 (b)
                     of the Act (see Exhibit 6 to Form T-1 filed in connection
                     with Registration Statement No. 333-41329, which is
                     incorporated by reference).

       Exhibit 7.    A copy of the latest report of condition of the Trustee,
                     published pursuant to law or the requirements of its
                     supervising or examining authority.

       Exhibit 8.    Not Applicable

       Exhibit 9.    Not Applicable


                                       2

<PAGE>

                                    SIGNATURE

           Pursuant to the requirements of the Trust Indenture Act of 1939, the
Trustee, Chase Manhattan Bank and Trust Company, National Association, has duly
caused this statement of eligibility and qualification to be signed on its
behalf by the undersigned, thereunto duly authorized, all in the City of San
Francisco, and State of California, on the 10 of March, 2000.

                                       CHASE MANHATTAN BANK AND TRUST
                                       COMPANY, NATIONAL ASSOCIATION

                                       By   /s/ Cecil D. Bobey
                                         ---------------------------
                                            Cecil D. Bobey
                                            Assistant Vice President


                                       3

<PAGE>

EXHIBIT 7.          Report of Condition of the Trustee.
- --------------------------------------------------------------------------------


CONSOLIDATED REPORT OF CONDITION OF Chase Manhattan Bank and Trust Company, N.A.
                                    --------------------------------------------
                                                     (Legal Title)

LOCATED AT  1800 Century Park East, Ste. 400    Los Angeles,   CA       94111
           ---------------------------------------------------------------------
               (Street)                            (City)      (State) (Zip)

AS OF CLOSE OF BUSINESS ON          December 31, 1999
                           -----------------------------------

================================================================================
================================================================================
ASSETS DOLLAR AMOUNTS IN THOUSANDS

<TABLE>
<S><C>
1.     Cash and balances due from
           a. Noninterest-bearing balances and currency and coin (1,2)                             4,258
           b. Interest bearing balances (3)                                                            0
2.     Securities
           a. Held-to-maturity securities (from Schedule RC-B, column A)                               0
           b. Available-for-sale securities (from Schedule RC-B, column D)                         1,089
3.     Federal Funds sold (4) and securities purchased agreements to resell                       82,900
4.     Loans and lease financing receivables:
           a. Loans and leases, net of unearned income (from Schedule RC-C)                68
           b. LESS: Allowance for loan and lease losses                                     0
           c. LESS: Allocated transfer risk reserve                                         0
           d. Loans and leases, net of unearned income, allowance, and
                reserve (item 4.a minus 4.b and 4.c)                                                  68
5.     Trading assets                                                                                  0
6.     Premises and fixed assets (including capitalized leases)                                     142
7.     Other real estate owned (from Schedule RC-M)                                                    0
8.     Investments in unconsolidated subsidiaries and associated companies
       (from Schedule RC-M)                                                                            0
9.     Customers liability to this bank on acceptances outstanding                                     0
10.    Intangible assets (from Schedule RC-M)                                                      1,026
11.    Other assets (from Schedule RC-F)                                                           1,996
12a.            TOTAL ASSETS                                                                      91,479


(1)  INCLUDES CASH ITEMS IN PROCESS OF COLLECTION AND UNPOSTED DEBITS.
(2)  THE AMOUNT REPORTED IN THIS ITEM MUST BE GREATER THAN OR EQUAL TO THE SUM
     OF SCHEDULE RC-M, ITEMS 3.a AND 3.b
(3)  INCLUDES TIME CERTIFICATES OF DEPOSIT NOT HELD FOR TRADING.
(4)  REPORT "TERM FEDERAL FUNDS SOLD" IN SCHEDULE RC, ITEM 4.a "LOANS AND
     LEASES, NET OF UNEARNED INCOME" AND IN SCHEDULE RC-C, PART 1.


                                       4
<PAGE>

LIABILITIES

13.    Deposits:
           a. In domestic offices (sum of totals of columns A and C from
                Schedule RC-E)                                                                    59,457
                (1) Noninterest-bearing                                            7,509
                (2) Interest-bearing                                              51,948
           b.   In foreign offices, Edge and Agreement subsidiaries, and IBF'
                (1) Noninterest-bearing
                (2) Interest-bearing
14.    Federal funds purchased (2) and securities sold under agreements to
       repurchase                                                                                      0
15.    a. Demand notes issued to the U.S. Treasury                                                     0
       b. Trading liabilities                                                                          0
16.    Other borrowed money (includes mortgage indebtedness and obligations
       under capitalized leases):
       a. With a remaining maturity of one year or less                                                0
       b. With a remaining maturity of more than one year through three years                          0
       c. With a remaining maturity of more than three years                                           0
17.    Not applicable
18.    Bank's liability on acceptances executed and outstanding                                        0
19.    Subordinated notes and Debentures (3)                                                           0
20.    Other liabilities (from Schedule RC-G)                                                      5,756
21.    Total liabilities (sum of items 13 through 20)                                             65,213
22.    Not applicable

EQUITY CAPITAL

23.    Perpetual preferred stock and related surplus                                                   0
24.    Common stock--                                                                                600
25.    Surplus (exclude all surplus related to preferred stock)                                   12,590
26.    a. Undivided profits and capital reserves                                                  13,076
       b. Net unrealized holding gains (losses) on available-for-sale securities                       0
27.    Cumulative foreign currency translation adjustments
28.    a. Total equity capital (sum of items 23 through 27)                                       26,266
29.    Total liabilities, equity capital, and losses deferred pursuant to 12 U.S.C.
       1823 (j) (sum of items 21 and 28.c)                                                        91,479
</TABLE>


                                       5

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE ANNUAL
FINANCIAL STATEMENTS OF INHALE THERAPUETIC SYSTEMS, INC. AS FILED ON FORM 10-K
FOR THE PERIOD ENDED DECEMBER 31, 1999. AND IS QUALIFIED IN ITS ENTIRETY BY
REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000

<S>                             <C>
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                          DEC-31-1999
<PERIOD-START>                             JAN-01-1999
<PERIOD-END>                               DEC-31-1999
<CASH>                                          33,430
<SECURITIES>                                   104,755
<RECEIVABLES>                                    1,756
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                 7,377
<PP&E>                                          78,861
<DEPRECIATION>                                (15,009)
<TOTAL-ASSETS>                                 226,806
<CURRENT-LIABILITIES>                           25,079
<BONDS>                                        108,450
                                0
                                          0
<COMMON>                                       181,156
<OTHER-SE>                                      94,527
<TOTAL-LIABILITY-AND-EQUITY>                   226,806
<SALES>                                              0
<TOTAL-REVENUES>                                41,358
<CGS>                                                0
<TOTAL-COSTS>                                   81,842
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             (2,075)
<INCOME-PRETAX>                               (38,448)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                                  0
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                         0
<EPS-BASIC>                                     (2.26)
<EPS-DILUTED>                                   (2.26)


</TABLE>


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