GENEMEDICINE INC
SC 13G/A, 1997-02-13
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G


                   Under the Securities Exchange Act of 1934

                               (Amendment No. 1)*


                               GeneMedicine, Inc.
                               ------------------
                                (Name of Issuer)

                         Common Stock, $.001 par value
                         -----------------------------
                         (Title of Class of Securities)

                                   0003687071
                                 --------------
                                 (CUSIP Number)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>

- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  2  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  New Enterprise Associates V, Limited Partnership                   |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  Delaware Limited Partnership                                       |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | PN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  3  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  NEA Partners V, Limited Partnership                                |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  Delaware Limited Partnership                                       |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | PN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  4  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Frank A. Bonsal, Jr.                                               |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States                                                      |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | IN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  5  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Nancy L. Dorman                                                    |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States                                                      |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | IN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  6  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  C. Richard Kramlich                                                |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States                                                      |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | IN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    

<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  7  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Arthur J. Marks                                                    |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States                                                      |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | IN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  8  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Thomas C. McConnell                                                |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States                                                      |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | IN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


- -------------------------                           ---------------------------
|CUSIP NO. 0003687071   |           13G            |   Page  9  of  19   Pages |
|          -----------  |                          |        ---     ---        |
- -------------------------                           ---------------------------

|--------|---------------------------------------------------------------------|
|  1     |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Charles W. Newhall III                                             |
|--------|---------------------------------------------------------------------|
|  2     |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  3     |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  4     |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  United States                                                      |
|--------|-----------------|--------|------------------------------------------|
|                          |   5    | SOLE VOTING POWER                        |
|                          |        | 0 shares                                 |
|        NUMBER OF         |--------| -----------------------------------------|
|         SHARES           |   6    | SHARED VOTING POWER                      |
|      BENEFICIALLY        |        | less than 5%                             |
|        OWNED BY          ----------------------------------------------------|
|          EACH            |   7    | SOLE DISPOSITIVE POWER                   |
|       REPORTING          |        | 0 shares                                 |
|         PERSON           ----------------------------------------------------|
|          WITH            |   8    | SHARED DISPOSITIVE POWER                 |
|                          |        | less than 5%                             |
|--------|---------------------------------------------------------------------|
|  9     | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON        |
|        |                                                                     |
|        | less than 5%                                                        |
|--------|- -------------------------------------------------------------------|
|  10    | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ]  |
|        | SHARES*                                                             |
|        |                                                                     |
|--------|- -------------------------------------------------------------------|
|  11    | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                   |
|        | less than 5%                                                        |
|--------|---------------------------------------------------------------------|
|  12    | TYPE OF REPORTING PERSON *                                          |
|        | IN                                                                  |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!                    


<PAGE>


Item 1(a).     Name of Issuer:  GeneMedicine, Inc.

Item 1(b).     Address of Issuer's Principal Executive Offices:
               8301 New Trails Drive, The Woodlands, Texas 77381-4248 

Item 2(a).     Names of Persons Filing:  New Enterprise Associates V, Limited
               Partnership ("NEA V"), NEA Partners V, Limited Partnership ("NEA
               Partners V"), which is the sole general partner of NEA V, and
               Frank A. Bonsal, Jr. ("Bonsal"), Nancy L. Dorman ("Dorman"), C.
               Richard Kramlich ("Kramlich"), Arthur J. Marks ("Marks") , Thomas
               C. McConnell ("McConnell") and Charles W. Newhall III ("Newhall")
               (the "General Partners). The persons named in this paragraph are
               referred to individually herein as a "Reporting Person" and
               collectively as the "Reporting Persons." 

Item 2(b).     Address of Principal Business Office or, if None, Residence: 
               The address of the principal business office of NEA V,
               NEA Partners V, and the General Partners is New Enterprise
               Associates, 1119 St. Paul Street, Baltimore, Maryland 21202. The
               address of the principal business office of Kramlich is New
               Enterprise Associates, 2490 Sand Hill Road, Menlo Park,
               California 94025. 

Item 2(c).     Citizenship: Each of NEA V and NEA Partners V is a limited 
               partnership organized under the laws of the State of Delaware. 
               Each of the General Partners is a United States citizen. 

Item 2(d).     Title of Class of Securities: Common Stock, $.001 par value 
               ("Common Stock").

Item 2(e).     CUSIP Number: 0003687071. 

Item 3.        If this statement is filed pursuant to Rules 13d-1(b), or 
               13d-2(b), check whether the person filing is a: 

               (a)  [ ]  Broker or Dealer registered under Section 15 of the
                         Securities Exchange Act of 1934 (the "Act"). 

               (b)  [ ]   Bank as defined in Section 3(a)(6) of the Act. 

               (c)  [ ]  Insurance Company as defined in Section 3(a)(19) 
                         of the Act. 

               (d)  [ ]  Investment Company registered under Section 8 of the 
                         Investment Company Act of 1940. 

               (e)  [ ]  Investment Adviser registered under Section 203
                         of the Investment Advisers Act of 1940. 

               (f)  [ ]  Employee Benefit Plan, Pension Fund which is subject 
                         to the provisions of the Employee Retirement Income 
                         Security Act of 1974 or Endowment Fund; see Rule 
                         13d-1(b)(1)(ii)(F) of the Act. 

               (g)  [ ]  Parent Holding Company, in accordance with Rule
                         13d-1(b)(ii)(G) of the Act. 

               (h)  [ ]  Group, in accordance with Rule 13d-1(b)(1)(ii)(H) of
                         the Act.

               Not applicable. This Schedule 13G is not being filed pursuant to
               Rule 13d-1(b) or Rule 13d-2(b).


                              Page 10 of 19 Pages
<PAGE>


Item 4.        Ownership. 
               ----------

               (a)  Amount Beneficially Owned: Each Reporting Person owns
                    beneficially less than 5% of the outstanding Common Stock of
                    GeneMedicine, Inc.

               (b) Percent of Class: Each Reporting Person: Less than 5%.

               (c) Number of shares as to which such person has:

                    (i)   sole power to vote or to direct the vote: 0 shares for
                          each Reporting Person.

                    (ii)  shared power to vote or to direct the vote: Less than
                          5% for each Reporting Person.

                    (iii) sole power to dispose or to direct the disposition of:
                          0 shares for each Reporting Person.

                    (iv)  shared power to dispose or to direct the disposition
                          of: Less than 5% for each Reporting Person.

Item 5.        Ownership of Five Percent or Less of a Class.
               ---------------------------------------------

               Each Reporting Person has ceased to be the beneficial owner of 
               more than 5% of the Common Stock of GeneMedicine, Inc. [X]

Item 6.        Ownership of More than Five Percent on Behalf of Another Person. 
               ---------------------------------------------------------------- 

               Not applicable.

Item 7.        Identification and Classification of the Subsidiary Which 
               --------------------------------------------------------- 
               Acquired the Security Being Reported on by the Parent Holding 
               --------------------------------------------------------------
               Company. 
               ---------

               Not applicable. 

Item 8.        Identification and Classification of Members of the Group. 
               ----------------------------------------------------------

               Not applicable. The Reporting Persons expressly disclaim 
               membership in a "group" as used in Rule 13d-1(b)(ii)(H). 

Item 9.        Notice of Dissolution of Group. 
               ------------------------------- 

               Not applicable. 

Item 10.       Certification. 
               -------------- 

               Not applicable. This statement on Schedule 13G is not filed 
               pursuant to Rule 13d-1(b).


                              Page 11 of 19 Pages
<PAGE>


                                   SIGNATURE
                                   ---------

     After reasonable inquiry and to the best of its knowledge and belief, each
of the undersigned certifies that the information set forth in this statement is
true, complete and correct.

Date:   February 10, 1997


NEW ENTERPRISE ASSOCIATES V, LIMITED PARTNERSHIP

By:   NEA PARTNERS V, LIMITED PARTNERSHIP

      By  -------------*--------------
          Charles W. Newhall III
          General Partner


NEA PARTNERS V, LIMITED PARTNERSHIP

By           *
  ---------------------------
    Charles W. Newhall III
    General Partner

             *
- --------------------------
Frank A. Bonsal, Jr.

             *
- --------------------------
C. Richard Kramlich

             *
- --------------------------
Arthur J. Marks

             *
- --------------------------
Thomas C. McConnell

             *
- --------------------------
Charles W. Newhall III


                              Page 12 of 19 Pages
<PAGE>


                                     *By:    /s/ Nancy L. Dorman
                                             ----------------------------------
                                             Nancy L. Dorman, in her individual
                                             capacity and as Attorney-in-Fact

- --------------------------------------------------------------------------------

This Schedule 13G was executed by Nancy L. Dorman pursuant to Powers of Attorney
filed with the Securities and Exchange Commission on February 13, 1992 in
connection with a Schedule 13G for Advanced Interventional Systems Inc. and on
February 13, 1995 in connection with a Schedule 13G for Acuity Imaging, Inc.,
which Powers of Attorney are incorporated herein by reference and copies of
which are attached hereto as Exhibit 2.


                              Page 13 of 19 Pages
<PAGE>


                                                                      Exhibit 1
                                                                      ---------

                                   AGREEMENT

          
     Pursuant to Rule 13d-1(f)(1) under the Securities Exchange Act of 1934, the
undersigned hereby agree that only one statement containing the information
required by Schedule 13G need be filed with respect to the ownership by each of
the undersigned of shares of Common Stock of GeneMedicine, Inc.

        EXECUTED as a sealed instrument this 10th day of February, 1997.


NEW ENTERPRISE ASSOCIATES V, LIMITED PARTNERSHIP

By:  NEA PARTNERS V, LIMITED PARTNERSHIP

     By              *
         ----------------------------
         Charles W. Newhall III
         General Partner


NEA PARTNERS V, LIMITED PARTNERSHIP

By              *
    --------------------------
    Charles W. Newhall III
    General Partner

            *
- --------------------------
Frank A. Bonsal, Jr.

            *
- --------------------------
C. Richard Kramlich

            *
- --------------------------
Arthur J. Marks

            *
- -------------------------
Thomas C. McConnell

            *
- --------------------------
Charles W. Newhall II


                              Page 14 of 19 Pages
<PAGE>


                                         By:  /s/ Nancy L. Dorman
                                                  ------------------------------
                                              Nancy L. Dorman, in her individual
                                              capacity and as Attorney-in-Fact

- --------------------------------------------------------------------------------

This Agreement was executed by Nancy L. Dorman pursuant to Powers of Attorney
filed with the Securities and Exchange Commission on February 13, 1992 in
connection with a Schedule 13G for Advanced Interventional Systems, Inc. and on
February 13, 1995 in connection with a Schedule 13G for Acuity Imaging, Inc.,
which Powers of Attorney are incorporated herein by reference and copies of
which are attached hereto as Exhibit 2.


                              Page 15 of 19 Pages
<PAGE>



                                                                       Exhibit 2
                                                                       ---------

                               POWER OF ATTORNEY

     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below hereby constitutes and appoints Nancy L. Dorman and Charles W. Newhall
III, and each of them, with full power to act without the other, his true and
lawful attorney-in-fact, with full power of substitution, to sign any and all
instruments, certificates and documents that may be necessary, desirable or
appropriate to be executed on behalf of himself as an individual or in his
capacity as a general partner of any partnership, pursuant to section 13 or 16
of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any
and all regulations promulgated thereunder, and to file the same, with all
exhibits thereto, and any other documents in connection therewith, with the
Securities and Exchange Commission, and with any other entity when and if such
is mandated by the Exchange Act or by the By-laws of the National Association of
Securities Dealers, Inc., granting unto said attorney-in-fact full power and
authority to do and perform each and every act and thing necessary, desirable or
appropriate, fully to all intents and purposes as he might or could do in
person, thereby ratifying and confirming all that said attorney-in-fact, or his
substitutes, may lawfully do or cause to be done by virtue hereof.

     IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 23rd
day of April, 1991.


                                                  /s/ Raymond L. Bank
                                                  -----------------------------
                                                  Raymond L. Bank


                                                  /s/ Thomas R. Baruch
                                                  -----------------------------
                                                  Thomas R. Baruch


                                                  /s/ Cornelius C. Bond, Jr.
                                                  -----------------------------
                                                  Cornelius C. Bond, Jr.


                                                  /s/ Frank A. Bonsal, Jr.
                                                  -----------------------------
                                                  Frank A. Bonsal, Jr.


                                                  /s/ James A. Cole
                                                  -----------------------------
                                                  James A. Cole


                              Page 16 of 19 Pages
<PAGE>


                                                  /s/ Nancy L. Dorman
                                                  -----------------------------
                                                  Nancy L. Dorman


                                                  /s/ Neal M. Douglas
                                                  -----------------------------
                                                  Neal M. Douglas


                                                  /s/ John W. Glynn, Jr.
                                                  -----------------------------
                                                  John W. Glynn, Jr.


                                                  /s/ Curran W. Harvey
                                                  -----------------------------
                                                  Curran W. Harvey


                                                  /s/ Ronald Kase
                                                  -----------------------------
                                                  Ronald Kase


                                                  /s/ C. Richard Kramlich
                                                  -----------------------------
                                                  C. Richard Kramlich


                                                  /s/ Robert F. Kuhling
                                                  -----------------------------
                                                  Robert F. Kuhling


                                                  /s/ Arthur J. Marks
                                                  -----------------------------
                                                  Arthur J. Marks


                                                  /s/ Thomas C. McConnell
                                                  -----------------------------
                                                  Thomas C. McConnell


                                                  /s/ Donald L. Murfin
                                                  -----------------------------
                                                  Donald L. Murfin


                                                  /s/ H. Leland Murphy
                                                  -----------------------------
                                                  H. Leland Murphy


                              Page 17 of 19 Pages
<PAGE>


                                                  /s/ John M. Nehra
                                                  -----------------------------
                                                  John M. Nehra


                                                  /s/ Charles W. Newhall III
                                                  -----------------------------
                                                  Charles W. Newhall III


                                                  /s/ Terry L. Opdendyk
                                                  -----------------------------
                                                  Terry L. Opdendyk


                                                  /s/ Barbara J. Perrier
                                                  -----------------------------
                                                  Barbara J. Perrier


                                                  /s/ C. Vincent Prothro
                                                  -----------------------------
                                                  C. Vincent Prothro


                                                  /s/ C. Woodrow Rea, Jr.
                                                  -----------------------------
                                                  C. Woodrow Rea, Jr.


                                                  /s/ Howard D. Wolfe, Jr.
                                                  -----------------------------
                                                  Howard D. Wolfe, Jr.


                                                  /s/ Nora M. Zietz
                                                  -----------------------------
                                                  Nora M. Zietz


                              Page 18 of 19 Pages
<PAGE>


                               POWER OF ATTORNEY

     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below hereby constitutes and appoints Nancy L. Dorman and Charles W. Newhall
III, and each of them, with full power to act without the other, his true and
lawful attorney-in-fact, with full power of substitution, to sign any and all
instruments, certificates and documents that may be necessary, desirable or
appropriate to be executed on behalf of himself as an individual or in his
capacity as a general partner of any partnership, pursuant to section 13 or 16
of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any
and all regulations promulgated thereunder, and to file the same, with all
exhibits thereto, and any other documents in connection therewith, with the
Securities and Exchange Commission, and with any other entity when and if such
is mandated by the Exchange Act or by the By-laws of the National Association of
Securities Dealers, Inc., granting unto said attorney-in-fact full power and
authority to do and perform each and every act and thing necessary, desirable or
appropriate, fully to all intents and purposes as he might or could do in
person, thereby ratifying and confirming all that said attorney-in-fact, or his
substitutes, may lawfully do or cause to be done by virtue hereof.

     IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 1st
day of January, 1994.

                                                  /s/ Peter J. Barris
                                                  -----------------------------
                                                  Peter J. Barris


                                                  /s/ Debra E. King
                                                  -----------------------------
                                                  Debra E. King


                                                  /s/ Peter T. Morris
                                                  -----------------------------
                                                  Peter T. Morris


                                                  /s/ Hugh Y. Rienhoff, Jr.
                                                  -----------------------------
                                                  Hugh Y. Rienhoff, Jr.


                                                  /s/ Alexander Slusky
                                                  -----------------------------
                                                  Alexander Slusky


                                                  /s/ Louis B. Van Dyck
                                                  -----------------------------
                                                  Louis B. Van Dyck


                              Page 19 of 19 Pages



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