GENEMEDICINE INC
DEFA14A, 1999-02-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION
 
                  Proxy Statement Pursuant to Section 14(a) of
             the Securities Exchange Act of 1934 (Amendment No. 2)
 
    Filed by the Registrant /X/
    Filed by a Party other than the Registrant / /
 
    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    / /  Definitive Proxy Statement
    /X/  Definitive Additional Materials
    / /  Soliciting Material Pursuant to Section240.14a-11(c) or
         Section240.14a-12
 
                                        GENEMEDICINE, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
                           MEGABIOS CORP./GENEMEDICINE, INC.
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
/ /  No fee required.
/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(1)
     and 0-11.
     (1) Title of each class of securities to which transaction applies:
         -----------------------------------------------------------------------
     (2) Aggregate number of securities to which transaction applies:
         -----------------------------------------------------------------------
     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
         filing fee is calculated and state how it was determined):
         -----------------------------------------------------------------------
     (4) Proposed maximum aggregate value of transaction:
         -----------------------------------------------------------------------
     (5) Total fee paid:
         -----------------------------------------------------------------------
/ /  Fee paid previously with preliminary materials.
/X/  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
     (1) Amount Previously Paid:
         $7,731.18
         -----------------------------------------------------------------------
     (2) Form, Schedule or Registration Statement No.:
         Form S-4  (333-68013)
         -----------------------------------------------------------------------
     (3) Filing Party:
         MEGABIOS CORP.
         -----------------------------------------------------------------------
     (4) Date Filed:
         February 10, 1999
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<TABLE>
<S>                                            <C>
   [LOGO]                                                                             [LOGO]
</TABLE>
 
                               February 22, 1999
 
To the Stockholders of Megabios Corp. and GeneMedicine, Inc.:
 
    Enclosed is a supplement to the Joint Proxy Statement/Prospectus, dated
February 11, 1999, delivered to each stockholder of record for the Special
Meetings of Stockholders to be held on March 18, 1999. The supplement corrects
an error in the number of GeneMedicine shares outstanding on the record date.
 
    If you have not already returned your proxy for the special meeting, please
do so as soon as possible. If you have lost or misplaced the form of proxy
previously mailed to you, please contact:
 
<TABLE>
<S>                                        <C>
FOR MEGABIOS CORP.                         FOR GENEMEDICINE, INC.
 
Bennet L. Weintraub                        Richard A. Waldron
Megabios Corp.                             GeneMedicine, Inc.
863A Mitten Road                           8301 New Trails Drive
Burlingame, CA 94010                       The Woodlands, TX 77381
(650) 697-1900                             (281) 362-2644
 
Sincerely,                                 Sincerely,
/s/ Benjamin F. McGraw III                 /s/ Stanley T. Crooke, M.D., Ph.D.
Benjamin F. McGraw III, Pharm. D.          Stanley T. Crooke, M.D., Ph.D.
Chairman of the Board and                  Chairman of the Board
Chief Executive Officer                    GeneMedicine, Inc.
Megabios Corp.
</TABLE>
<PAGE>
                       MEGABIOS CORP./GENEMEDICINE, INC.
                 SUPPLEMENT TO JOINT PROXY STATEMENT/PROSPECTUS
                            DATED FEBRUARY 11, 1999
 
    The Joint Proxy Statement/Prospectus, dated February 11, 1999, delivered to
each stockholder of record of Megabios Corp. and GeneMedicine, Inc. is hereby
supplemented in the following respects:
 
        1. the shares of GeneMedicine common stock outstanding on the record
    date disclosed on pages 3 and 22 is amended to read "15,755,303;" and
 
        2. the percentage of shares of GeneMedicine common stock owned by
    officers and directors as of the record date disclosed on page 3 is amended
    to read "3.3%."
 
    February 22, 1999


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