HYSEQ INC
8-K, 2000-04-14
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                    FORM 8-K
                                 CURRENT REPORT



                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934



                                  April 7, 2000
                        (Date of earliest event reported)


                                   HYSEQ, INC.
             (Exact name of Registrant as specified in its charter)



        Nevada                      0-22873                     36-3855489
      (State of              (Commission File No.)            (IRS Employer
     Incorporation)                                        Identification No.)



                               670 Almanor Avenue
                           Sunnyvale, California 94086
          (Address of principal executive offices, including zip code)

                                 (408) 524-8100
              (Registrant's telephone number, including area code)






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Item 4.  Changes in Registrant's Certifying Accountant.

         On April 7, 2000, the Registrant contacted its former independent
accountants, Ernst & Young LLP ("E&Y") to advise them that prospective new
independent accountants would contact them as part of their due diligence. The
Registrant subsequently confirmed to E&Y that they were dismissed effective as
of April 7, 2000.

         During the fiscal years ended December 31, 1999 and 1998 and the
subsequent interim period, there were no disagreements with the former
accountants on any matter of accounting principles or practices, financial
statement disclosures, or auditing scope or procedure which would have caused
the former accountants to make reference in their report to such disagreements
if not resolved to their satisfaction.

         E&Y's reports on the financial statements for the years ended December
31, 1999 and 1998, contained no adverse opinion or disclaimer of opinion and
were not modified as to uncertainty, audit scope or accounting principles.

         The prospective independent accountants have not completed their due
diligence review of the Registrant and accordingly new independent accountants
have not been engaged as of the date of this Report on Form 8-K. Authorization
to seek new independent accountants was approved by the Audit Committee and
Board of Directors of the Registrant.

         The Registrant has provided E&Y with a copy of this disclosure and
requested that E&Y furnish it with a letter addressed to the Securities and
Exchange Commission stating whether it agrees with the above statements. A copy
of the aforementioned letter is attached as an exhibit hereto.

Item 7.  Financial Statements and Exhibits.

(c)      Exhibits

         16      Former Accountants Letter







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                                    SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                  HYSEQ, INC.

                                                  /s/ Mark E. Gitter
                                                  ------------------------------
                                                  Name: Mark E. Gitter
                                                  Title: Chief Financial Officer
Date: April 13, 2000




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                                  EXHIBIT INDEX



Exhibit No.                        Description of Exhibit
- -----------                        ----------------------

   16                              Former Accountants Letter




<PAGE>   1


                                                                      EXHIBIT 16




April 12, 2000



Securities and Exchange Commission
450 Fifth St. NW
Washington, D.C. 20549

Gentlemen:

We have read Item 4 of Form 8-K dated April 7, 2000, of Hyseq, Inc. and are in
agreement with the statements contained in the last sentence of the first
paragraph on page 2, the second and third paragraphs on page 2, and the first
sentence of the fifth paragraph on page 2. We have no basis to agree or disagree
with other statements of the registrant contained therein.





                                                     /s/ Ernst & Young LLP




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