<TABLE> <S> <C>
<ARTICLE> 5
<LEGEND>
THE TABLE BELOW HOLDS SUMMARY FINANCIAL INFORMATION CONTAINED IN HYSEQ,
INC. INTERIM FINANCIAL REPORT ON FORM 10-Q FOR THE PERIOD ENDED SEPTEMBER
30, 2000 AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL
STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
<S> <C>
<PERIOD-TYPE> 3-MOS
<FISCAL-YEAR-END> DEC-31-2000
<PERIOD-START> JUL-01-2000
<PERIOD-END> SEP-30-2000
<CASH> 11,843
<SECURITIES> 1,470
<RECEIVABLES> 115
<ALLOWANCES> 0
<INVENTORY> 0
<CURRENT-ASSETS> 15,961
<PP&E> 20,164
<DEPRECIATION> (8,106)
<TOTAL-ASSETS> 31,227
<CURRENT-LIABILITIES> 11,296
<BONDS> 0
0
0
<COMMON> 79,851
<OTHER-SE> (65,253)
<TOTAL-LIABILITY-AND-EQUITY> 31,227
<SALES> 0
<TOTAL-REVENUES> 5,936
<CGS> 0
<TOTAL-COSTS> 0
<OTHER-EXPENSES> 10,135
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> (229)
<INCOME-PRETAX> (4,116)
<INCOME-TAX> 0
<INCOME-CONTINUING> (4,116)
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> (4,116)
<EPS-BASIC> (0.30)
<EPS-DILUTED> (0.30)
</TABLE>