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<TABLE> <S> <C>
<ARTICLE> 5
<LEGEND>
THIS TABLE BELOW HOLDS SUMMARY FINANCIAL INFORMATION CONTAINED IN HYSEQ, INC.
INTERIM FINANCIAL REPORT ON FORM 10-Q FOR THE PERIOD ENDED JUNE 30, 2000 AND IS
QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
<S> <C>
<PERIOD-TYPE> 3-MOS
<FISCAL-YEAR-END> DEC-31-2000
<PERIOD-START> APR-01-2000
<PERIOD-END> JUN-30-2000
<CASH> 14,657
<SECURITIES> 7,732
<RECEIVABLES> 1,623
<ALLOWANCES> 0
<INVENTORY> 0
<CURRENT-ASSETS> 24,643
<PP&E> 18,216
<DEPRECIATION> (7,216)
<TOTAL-ASSETS> 38,217
<CURRENT-LIABILITIES> 14,173
<BONDS> 0
0
0
<COMMON> 79,267
<OTHER-SE> (61,151)
<TOTAL-LIABILITY-AND-EQUITY> 38,217
<SALES> 0
<TOTAL-REVENUES> 3,574
<CGS> 0
<TOTAL-COSTS> 0
<OTHER-EXPENSES> 8,905
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> (201)
<INCOME-PRETAX> (5,112)
<INCOME-TAX> 0
<INCOME-CONTINUING> (5,112)
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> (5,112)
<EPS-BASIC> (0.38)
<EPS-DILUTED> (0.38)
</TABLE>
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