OPTICAL SENSORS INC
DEF 14A, 1998-04-02
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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<PAGE>

                   U.S. SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549
 
================================================================================
 
                           SCHEDULE 14A INFORMATION

          Proxy Statement Pursuant to Section 14(a) of the Securities
                            Exchange Act of 1934
        
Filed by the Registrant [X]

Filed by a Party other than the Registrant [_] 

Check the appropriate box:

[_]  Preliminary Proxy Statement        [_]  Confidential, for Use of the 
                                             Commission Only (as permitted by
                                             Rule 14a-6(e)(2))
[X]  Definitive Proxy Statement 

[_]  Definitive Additional Materials 

[_]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                        OPTICAL SENSORS INCORPORATED
- --------------------------------------------------------------------------------
               (Name of Registrant as Specified In Its Charter)

                        OPTICAL SENSORS INCORPORATED
- --------------------------------------------------------------------------------
                 (Name of Person(s) Filing Proxy Statement)

   
Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.

[_]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

   
     (1) Title of each class of securities to which transaction applies:

     -------------------------------------------------------------------------


     (2) Aggregate number of securities to which transaction applies:

     -------------------------------------------------------------------------


     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
         the filing fee is calculated and state how it was determined):

     -------------------------------------------------------------------------
      

     (4) Proposed maximum aggregate value of transaction:

     -------------------------------------------------------------------------


     (5) Total fee paid:

     -------------------------------------------------------------------------

[_]  Fee paid previously with preliminary materials.
     
[_]  Check box if any part of the fee is offset as provided by Exchange
     Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.
     
     (1) Amount Previously Paid:
 
     -------------------------------------------------------------------------


     (2) Form, Schedule or Registration Statement No.:

     -------------------------------------------------------------------------


     (3) Filing Party:
      
     -------------------------------------------------------------------------


     (4) Date Filed:

     -------------------------------------------------------------------------

Notes:



<PAGE>
 
                         OPTICAL SENSORS INCORPORATED
                      7615 GOLDEN TRIANGLE DRIVE, SUITE A
                         MINNEAPOLIS, MINNESOTA 55344
 
TO THE STOCKHOLDERS OF OPTICAL SENSORS INCORPORATED:
 
  You are cordially invited to attend our Annual Meeting of Stockholders to be
held on May 7, 1998, at 3:30 p.m., local time, at the Marquette Hotel, 710
Marquette Avenue, Minneapolis, Minnesota.
 
  The formal Notice of Meeting, Proxy Statement and form of proxy are
enclosed.
 
  Whether or not you plan to attend the meeting, please date, sign and return
the enclosed proxy in the envelope provided as soon as possible so that your
vote will be recorded.
 
                                          Very truly yours,
 

                                          /s/ Sam B. Humphries
                                          Sam B. Humphries
                                          President and Chief Executive
                                          Officer
 
April 2, 1998
 
                         PLEASE SIGN, DATE AND RETURN
                          THE ENCLOSED PROXY PROMPTLY
                        TO SAVE THE COMPANY THE EXPENSE
                          OF ADDITIONAL SOLICITATION.
<PAGE>
 
                         OPTICAL SENSORS INCORPORATED
                      7615 GOLDEN TRIANGLE DRIVE, SUITE A
                         MINNEAPOLIS, MINNESOTA 55344
 
                               ----------------
 
                   NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD MAY 7, 1998
 
                               ----------------
 
TO THE STOCKHOLDERS OF OPTICAL SENSORS INCORPORATED:
 
  Notice is hereby given that the Annual Meeting of Stockholders of Optical
Sensors Incorporated, a Delaware corporation (the "Company"), will be held on
Thursday, May 7, 1998, at 3:30 p.m., local time, at the Marquette Hotel, 710
Marquette Avenue, Minneapolis, Minnesota, for the following purposes:
 
  1. To elect five (5) persons to serve as directors until the next annual
     meeting of stockholders or until their respective successors shall be
     elected and qualified.
 
  2. To ratify the appointment of Ernst & Young LLP, certified public
     accountants, as independent auditors for the Company for the fiscal year
     ending December 31, 1998.
 
  3. To consider and act upon such other matters as may properly come before
     the meeting or any adjournment thereof.
 
  Only stockholders of record at the close of business on March 13, 1998 will
be entitled to notice of, and to vote at, the meeting and any adjournments
thereof.
 
                                          By Order of the Board of Directors,
 
                                          
                                          /s/ Wesley G. Peterson
                                          Wesley G. Peterson
                                          Secretary
 
April 2, 1998
Minneapolis, Minnesota
 
   YOU ARE CORDIALLY INVITED TO ATTEND THE ANNUAL MEETING. NO ADMISSION
 TICKET OR OTHER CREDENTIALS WILL BE NECESSARY. IF YOU DO NOT PLAN TO ATTEND
 THE MEETING, PLEASE BE SURE YOU ARE REPRESENTED AT THE MEETING BY MARKING,
 SIGNING, DATING AND MAILING YOUR PROXY IN THE REPLY ENVELOPE PROVIDED.
 
<PAGE>
 
                         OPTICAL SENSORS INCORPORATED
                      7615 GOLDEN TRIANGLE DRIVE, SUITE A
                         MINNEAPOLIS, MINNESOTA 55344
 
                               ----------------
 
                                PROXY STATEMENT
                                      FOR
                        ANNUAL MEETING OF STOCKHOLDERS
 
                                  MAY 7, 1998
 
                               ----------------
 
                                 INTRODUCTION
 
  The Annual Meeting of Stockholders of Optical Sensors Incorporated (the
"Company") will be held on Thursday, May 7, 1998, at 3:30 p.m., local time, at
the Marquette Hotel, 710 Marquette Avenue, Minneapolis, Minnesota, or at any
adjournment or adjournments thereof (the "Annual Meeting"), for the purposes
set forth in the Notice of Meeting.
 
  A proxy card is enclosed for your use. You are solicited on behalf of the
Board of Directors to SIGN AND RETURN THE PROXY CARD IN THE ACCOMPANYING
ENVELOPE. No postage is required if mailed within the United States. The cost
of soliciting proxies, including the preparation, assembly and mailing of
proxies and soliciting material, as well as the cost of forwarding such
material to the beneficial owners of the Company's common stock, $.01 par
value (the "Common Stock") will be borne by the Company. Directors, officers
and regular employees of the Company may, without compensation other than
their regular compensation, solicit proxies by telephone, telegraph or
personal conversation. The Company may reimburse brokerage firms and others
for expenses in forwarding proxy materials to the beneficial owners of the
Common Stock.
 
  Any stockholder giving a proxy may revoke it at any time prior to its use at
the Annual Meeting either by giving written notice of such revocation to the
Secretary of the Company, by filing a duly executed proxy bearing a later date
with the Secretary of the Company, or by appearing at the Annual Meeting and
filing written notice of revocation with the Secretary of the Company prior to
use of the proxy. Proxies will be voted as specified by stockholders. Proxies
that are signed by stockholders but that lack any such specification will be
voted in favor of the proposals set forth in the Notice of Meeting and in
favor of the election as directors of the nominees for directors listed in
this Proxy Statement.
 
  THE BOARD RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE APPROVAL OF THE
PROPOSALS SET FORTH IN THE NOTICE OF MEETING.
 
  The Company expects that this proxy material will first be mailed to
stockholders on or about April 2, 1998.
 
                               VOTING OF SHARES
 
  Only holders of the Common Stock of record at the close of business on March
13, 1998 will be entitled to vote at the Annual Meeting. On March 13, 1998,
the Company had 8,848,764 outstanding shares of Common Stock, each such share
entitling the holder thereof to one vote on each matter to be voted on at the
Annual Meeting.
 
  The presence at the Annual Meeting, in person or by proxy, of the holders of
a majority of the outstanding shares of Common Stock entitled to vote at the
Annual Meeting (4,424,383 shares) will
<PAGE>
 
constitute a quorum for the transaction of business at the Annual Meeting. In
general, shares of Common Stock represented by a properly signed and returned
proxy card will be counted as shares present and entitled to vote at the
Annual Meeting for purposes of determining a quorum, without regard to whether
the card reflects abstentions (or is left blank) or reflects a "broker non-
vote" on a matter (i.e., a card returned by a broker on behalf of its
beneficial owner customer that is not voted on a particular matter because
voting instructions have not been received and the broker has no discretionary
authority to vote).
 
  Holders of shares of Common Stock are not entitled to cumulate voting
rights.
 
  The election of a nominee for director requires the approval of a plurality
of the shares present and entitled to vote in person or by proxy and the
approval of the other proposals described in this Proxy Statement requires the
approval of a majority of the shares present and entitled to vote in person or
by proxy on that matter (and at least a majority of the minimum number of
votes necessary for a quorum to transact business at the Annual Meeting).
Shares represented by a proxy card including any broker non-votes on a matter
will be treated as shares not entitled to vote on that matter, and thus will
not be counted in determining whether that matter has been approved. Shares
represented by a proxy card voted as abstaining on any of the proposals will
be treated as shares present and entitled to vote that were not cast in favor
of a particular matter, and thus will be counted as votes against that matter.
 
                             ELECTION OF DIRECTORS
 
                                  PROPOSAL 1
 
NOMINATION
 
  The Bylaws of the Company provide that the number of directors must be at
least one or such other number as shall be fixed from time to time by
resolution of the Board of Directors. The Board of Directors of the Company
(the "Board") has set its size at five and has nominated the five individuals
named below to serve as directors of the Company until the next annual meeting
of stockholders or until their respective successors have been elected and
qualified. All of the nominees are current members of the Board. Mr.
Humphries, Dr. Nicoloff and Mr. Peterson were elected at the 1997 Annual
Meeting of Stockholders, and Mr. Egen and Mr. Meelia were elected by the
Board, pursuant to its authority under the Company's Bylaws to elect directors
between stockholder meetings, in June 1997. Promod Haque, Ph.D., a current
member of the Board, is not standing for reelection, and Peter McNerney and
John Nehra, both of whom were also elected at the 1997 Annual Meeting of
Stockholders, have resigned from the Board. The Company would like to thank
all three of these individuals for their dedicated service to the Company.
 
  Assuming a quorum is represented at the Annual Meeting, either in person or
by proxy, the election of each director requires the affirmative vote of a
plurality of the shares of Common Stock represented in person or by proxy at
the Annual Meeting. The Board recommends a vote FOR the election of each of
the nominees listed below. In absence of other instructions, the proxies will
be voted FOR the election of each of the nominees named below. If prior to the
Annual Meeting the Board should learn that any nominee will be unable to serve
by reason of death, incapacity or other unexpected occurrence, the proxies
that otherwise would have been voted for such nominee will be voted for such
substitute nominee as selected by the Board. Alternatively, the proxies, at
the Board's discretion, may be voted for such fewer number of nominees as
results from such death, incapacity or other unexpected occurrence. The Board
has no reason to believe that any of the nominees will be unable to serve.
 
                                       2
<PAGE>
 
INFORMATION ABOUT NOMINEES
 
  The following table sets forth certain information as of February 1, 1998,
which has been furnished to the Company by each of the persons who has been
nominated by the Board to serve as directors for the ensuing year.
 
<TABLE>
<CAPTION>
                                                                              DIRECTOR
NAME OF NOMINEE          AGE               PRINCIPAL OCCUPATION                SINCE
- ---------------          ---               --------------------               --------
<S>                      <C> <C>                                              <C>
Sam B. Humphries........  55 President and Chief Executive Officer of the       1991
                              Company
Richard B. Egen (1).....  59 President and Chief Executive Officer of NephRx    1997
                              Corporation
Richard J. Meelia (2)...  48 President and Chief Executive Officer of The       1997
                              Kendall Company
Demetre M. Nicoloff,      64 Cardiac Surgeon and Senior Partner of Cardiac      1989
 M.D....................      Surgical Associates
Gary A. Peterson (2)....  46 President and Chief Executive Officer of BATON     1990
                              Development, Inc.
</TABLE>
- --------
(1) Member of the Audit Committee
(2) Member of the Compensation Committee
 
OTHER INFORMATION ABOUT NOMINEES
 
  SAM B. HUMPHRIES has been the President, Chief Executive Officer and a
Director of the Company since October 1991. From January 1988 to October 1991,
he served as President and Chief Executive Officer of American Medical
Systems, a medical device manufacturer which is a subsidiary of Pfizer, Inc.
Mr. Humphries also served as a member of the Board of Directors of the
Hospital Products Group at Pfizer, Inc. Mr. Humphries is a Director of
Universal Hospital Services, Inc.
 
  RICHARD B. EGEN has been a Director of the Company since June 1997. Mr. Egen
is the President and Chief Executive Officer of NephRx Corporation, a
biotechnology company formed to commercialize kidney growth factor technology
developed at the University of Chicago. From January 1996 to December 1996,
Mr. Egen served as a consultant to Baxter International, Inc. ("Baxter") and
Nestle, S.A. ("Nestle") for clinical nutrition and start up medical companies.
From January 1989 to December 1995, he served as President and Chief Executive
Officer of Clintec International, Inc., a joint venture between Baxter and
Nestle that develops, manufactures, markets and distributes clinical nutrition
solutions and formulations. Prior to joining Clintec International, Inc., Mr.
Egen served in several positions at Baxter, including Senior Vice President
and a member of Baxter's Senior Management Committee. Mr. Egen is a member of
the Board of Directors of Aksys, Ltd.
 
  RICHARD J. MEELIA has been a Director of the Company since June 1997. Mr.
Meelia has been the President and Chief Executive Officer of The Kendall
Company, a wholly-owned subsidiary of Tyco International Ltd. that
manufactures a diverse line of healthcare and specialty products, since July
1995. From January 1991 to July 1995, Mr. Meelia served as Group President of
Kendall Healthcare Products Company. From January 1987 to December 1990, Mr.
Meelia served as President of Infusaid, Inc., a division of Pfizer, Inc. that
manufactures and markets implantable infusion pumps and ports. From 1973 to
1987, he served in a variety of sales and marketing positions with divisions
of American Hospital Supply Corporation.
 
  DEMETRE M. NICOLOFF, M.D. has been a Director of the Company since July
1989. Dr. Nicoloff has been a cardiac surgeon for more than 15 years, and is
presently a Senior Partner of Cardiac Surgical Associates with practices at
the Minneapolis Heart Institute and the St. Paul Heart and Lung Institute. Dr.
Nicoloff is a member of the Board of Directors of Possis Medical, Inc. and
Applied Biometrics, Inc.
 
                                       3
<PAGE>
 
  GARY A. PETERSON has been a Director of the Company since June 1990. Mr.
Peterson is the President and Chief Executive Officer of BATON Development,
Inc., a virtual incubator for medical products, as well as the Managing Member
of BATON Ventures L.L.C. and the Venture Partner in Affinity Ventures II
L.L.C., both venture capital funds. Mr. Peterson has also been the President
of Peterson-Spencer-Fansler Company, a capital sourcing and operational
consulting company since 1991 and a General Partner of PSF Advisors, the
General Partner of PSF Health Care Fund L.P., a venture capital limited
partnership. He was also President of Peterson-Spencer-Fansler Investments,
Inc., a registered broker-dealer and a registered investment advisor. From
1986 through 1994, Mr. Peterson served as President of Genesis Venture
Development, Inc., a venture capital fund management company. Mr. Peterson was
a founder of Angiomedics Incorporated and served in the capacities of Chief
Operating Officer and Executive Vice President from its inception in 1983 to
1986 at which time Angiomedics was acquired by Pfizer, Inc. Mr. Peterson
continues to be a director of numerous medical companies.
 
INFORMATION ABOUT THE BOARD AND ITS COMMITTEES
 
  The Board of Directors met or took written action twelve times during 1997.
All of the Directors attended 75% or more of the meetings of the Board and all
such committees on which they served during 1997.
 
  The Board has established an Audit Committee and a Compensation Committee.
The Audit Committee provides assistance to the Board in satisfying its
fiduciary responsibilities relating to accounting, auditing, operating and
reporting practices of the Company, and reviews the annual financial
statements of the Company, the selection and work of the Company's independent
auditors and the adequacy of internal controls for compliance with corporate
policies and directives. During 1997, the Audit Committee consisted of Dr.
Haque and Mr. McNerney and met once during fiscal 1997. Effective January 1,
1998, Mr. Egen was elected to the Audit Committee replacing Mr. McNerney and
the Board intends to elect a replacement for Dr. Haque following the Annual
Meeting.
 
  The Compensation Committee makes recommendations to the Board of Directors
concerning the compensation of the Company's directors, executive officers and
key managers, and acts on such other matters relating to their compensation as
it deems appropriate. In addition, the Compensation Committee administers the
Company's stock option plans, pursuant to which incentive stock options and
non-statutory stock options may be granted to eligible key employees,
officers, directors and consultants of the Company and the Company's Employee
Stock Purchase Plan pursuant to which employees of the Company may purchase
shares of Common Stock directly from the Company on favorable terms through
payroll deductions. The Compensation Committee consisted of Mr. Nehra and Mr.
Peterson from January 1997 through November 1997. Effective December 1, 1997,
Mr. Meelia was elected to the Compensation Committee filling the vacancy
created when Mr. Nehra resigned from the Board. The Compensation Committee met
or took written action nine times during fiscal 1997. Mr. Meelia and Mr.
Peterson will serve as members of the Compensation Committee during fiscal
1998. See "Executive Compensation and Other Benefits--Compensation Committee
Report on Executive Compensation."
 
DIRECTOR COMPENSATION
 
  Directors of the Company receive no cash compensation for their services as
members of the Board of Directors, although their out-of-pocket expenses
incurred on behalf of the Company are reimbursed. Prior to October 1995, the
Company's 1993 Stock Option Plan provided for the automatic grant to each
director who is not an employee of the Company an option to purchase 888
shares of Common Stock on each anniversary of their initial election to the
Board, which became exercisable one year after the date of the grant. On
October 3, 1995, this provision in the 1993 Stock Option Plan was terminated
and all of the non-employee directors of the Company were granted an option to
 
                                       4
<PAGE>
 
purchase 15,555 shares of Common Stock at a price of $2.70 per share. These
options become exercisable, on a cumulative basis, with respect to 25% of the
shares covered by the option, on each of the first four anniversary dates of
the grant. In June 1997, each of Messrs. Egen and Meelia were granted an
option to purchase 16,000 shares of Common Stock at a price equal to the
market value on the date of the grant. These options become exercisable, on a
cumulative basis, with respect to 25% of the shares covered by the option, on
each of the first four anniversary dates of the grant.
 
                     PRINCIPAL STOCKHOLDERS AND BENEFICIAL
                            OWNERSHIP OF MANAGEMENT
 
  The following table sets forth information regarding the beneficial
ownership of the Common Stock of the Company as of March 13, 1998, unless
otherwise noted, (a) by each stockholder who is known by the Company to own
beneficially more than 5% of the outstanding Common Stock; (b) by each
director; (c) by each executive officer named in the Summary Compensation
Table; and (d) by all executive officers and directors of the Company as a
group.
 
<TABLE>
<CAPTION>
                                                      SHARES OF COMMON STOCK
                                                      BENEFICIALLY OWNED(1)
                                                      ---------------------------
                                                                    PERCENT OF
NAME                                                    AMOUNT       CLASS(2)
- ----                                                  ------------- -------------
<S>                                                   <C>           <C>
Norwest Venture Capital (3)..........................       837,574         9.4%
Trustees of the General Electric Pension Trust (4)...       476,190         5.4%
Coral Partners II, a limited partnership (5).........       444,859         5.0%
Richard B. Egen......................................             0           *
Sam B. Humphries (6).................................       152,927         1.7%
Promod Haque, Ph.D. (7)..............................       848,238         9.6%
Richard J. Meelia....................................             0           *
Demetre M. Nicoloff, M.D. (8)........................        70,230           *
Gary A. Peterson (9).................................        96,172         1.1%
Paulita M. LaPlante (10).............................        66,530           *
Byron (Buzz) Moran (11)..............................        49,818           *
Wesley G. Peterson (12)..............................        61,813           *
All directors and executive officers
 as a group (9 persons) (13).........................     1,345,728        14.9%
</TABLE>
- --------
   * Less than 1% of the outstanding shares.
 (1) Except as otherwise indicated in the footnotes to this table, the persons
     named in the table have sole voting and investment power with respect to
     all shares of Common Stock. Shares of Common Stock subject to options or
     warrants currently exercisable or exercisable within 60 days are deemed
     outstanding for computing the percentage of the person or group holding
     such options but are not deemed outstanding for computing the percentage
     of any other person or group.
 (2) Based on 8,848,764 shares of Common Stock outstanding as of March 13,
     1998.
 (3) Based on Schedule 13G filed February 5, 1998. Includes 366,834 shares
     held of record by Norwest Equity Partners IV and 453,225 shares held of
     record by Norwest Equity Partners V. Also includes 6,771 and 10,744
     shares issuable upon exercise of outstanding warrants held by Norwest
     Equity Partners IV and Norwest Equity Partners V, respectively. Itasca
     Partners is the general partner of Norwest Equity Partners IV and may be
     deemed to be the beneficial owner of shares held by Norwest Equity
     Partners IV. Itasca Partners V is the general partner of Norwest Equity
     Partners V and may be deemed to be the beneficial owner of shares held by
     Norwest Equity Partners V. Daniel J. Haggerty, by virtue of his
     affiliation with Norwest Equity Partners IV and Norwest Equity Partners
     V, may be deemed to be the beneficial owner of shares held by Norwest
     Equity Partners IV and Norwest Equity Partners V; however he disclaims
     beneficial ownership of such shares, except to the extent of his
     pecuniary interest therein. John E. Lindahl
 
                                       5
<PAGE>
 
    and George J. Still, by virtue of their affiliation with Norwest Equity
    Partners V, each may be deemed to be the beneficial owner of shares held
    by Norwest Equity Partners V; however they disclaim beneficial ownership
    of such shares, except to the extent of their pecuniary interest therein.
    The address of Norwest Venture Capital and the other named individuals is
    2800 Piper Tower, 222 South Ninth Street, Minneapolis, Minnesota 55402.
    Promod Haque, Ph.D., a director of the Company who is not standing for
    reelection, is a general partner of Itasca Partners and Itasca Partners V
    and is an officer of Norwest Venture Capital Management, Inc. Does not
    include shares held of record by Dr. Haque. See note (7) below.
 (4) Based on a Schedule 13G filed February 14, 1997. General Electric
     Investment Corporation ("GEIC") is the investment advisor to the Trustees
     of the General Electric Pension Trust ("GEPT") and may be deemed a
     beneficial owner of such shares. GEPT and GEIC share voting and
     investment power with respect to such shares. The address of GEPT and
     GEIC is 3003 Summer Street, Stamford, Connecticut 06904-7900.
 (5) Based on Schedule 13G filed February 5, 1998. Includes 4,034 shares
     issuable upon exercise of outstanding warrants held by Coral Partners II,
     a limited partnership ("Coral Partners II") and 10,109 shares issuable
     upon exercise of outstanding options held by Coral Group Inc. ("Coral").
     Coral Management Partners II, Limited Partnership ("CMP II"), is the
     general partner of Coral Partners II. Coral is the management company of
     CMP II. The address of Coral Partners II is 60 South 6th Street, Suite
     3510, Minneapolis, Minnesota 55402.
 (6) Includes 227 shares issuable upon exercise of outstanding warrants held
     by Mr. Humphries and 6,805 shares issuable upon exercise of outstanding
     options held by Mr. Humphries. Mr. Humphries' address is 7615 Golden
     Triangle Drive, Suite A, Minneapolis, Minnesota 55344.
 (7) Includes 10,664 shares issuable upon exercise of outstanding options held
     by Dr. Haque. Also includes all shares beneficially owned by Norwest
     Equity Partners IV and Norwest Equity Partners V, as to which shares Dr.
     Haque disclaims beneficial ownership except to the extent of any
     pecuniary interest therein. Dr. Haque's business address is Norwest
     Venture Capital, 245 Litton Avenue, Suite 250, Palo Alto, California
     94301. See note (3) above.
 (8) Includes 4,071 shares issuable upon exercise of outstanding stock options
     and warrants held by Dr. Nicoloff. Also includes 5,000 shares held by
     Nicoloff Properties, as to which Dr. Nicoloff disclaims any beneficial
     interest except to the extent of his pecuniary interest therein. Dr.
     Nicoloff is the managing agent of Nicoloff Properties.
 (9) Includes 10,661 shares issuable upon exercise of outstanding options and
     warrants held by Mr. Peterson. Also includes 68,796 shares held of record
     by PSF Health Care Fund L.P. ("PSF"), 1,110 shares issuable upon exercise
     of options held by PSF, as to which Mr. Peterson disclaims any beneficial
     ownership except to the extent of any pecuniary interest therein. PSF
     Advisors is the general partner of PSF, and Mr. Peterson is a general
     partner of PSF Advisors.
(10) Includes 64,443 shares issuable upon exercise of outstanding options held
     by Ms. LaPlante.
(11) Includes 26,374 shares issuable upon exercise of outstanding options held
     by Mr. Moran.
(12) Includes 22,267 shares issuable upon exercise of outstanding options held
     by Mr. Peterson. Also includes 15,873 shares held by Mr. Peterson's
     spouse.
(13) Includes 164,137 shares issuable upon exercise of outstanding options and
     warrants held by officers and directors or their affiliates. Also
     includes all shares beneficially owned by Mr. Peterson's spouse, Norwest
     Equity Partners IV, Norwest Equity Partners V and PSF. See notes (3),
     (8), (9) and (12) above.
 
                   EXECUTIVE COMPENSATION AND OTHER BENEFITS
 
SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION
 
  The following table provides summary information concerning cash and non-
cash compensation paid to or earned by the Company's Chief Executive Officer
and the executive officers of the Company,
 
                                       6
<PAGE>
 
all of whom received or earned cash and non-cash salary and bonus of more than
$100,000 for the fiscal year ended December 31, 1997 (the "Named Executive
Officers").
 
                          SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                       LONG-TERM
                                        ANNUAL COMPENSATION           COMPENSATION
                              ---------------------------------------  SECURITIES   ALL OTHER
                                                       OTHER ANNUAL    UNDERLYING  COMPENSATION
NAME AND PRINCIPAL POSITION   YEAR SALARY($) BONUS($) COMPENSATION($)  OPTIONS(#)     ($)(1)
- ---------------------------   ---- --------- -------- --------------- ------------ ------------
<S>                           <C>  <C>       <C>      <C>             <C>          <C>
Sam B. Humphries              1997 $185,000  $25,300      $ 6,000(2)     25,000       $5,000
President and Chief Execu-
 tive Officer                 1996  175,717   46,126        6,000(2)     27,222        2,365
                              1995  172,992   60,000        6,000(2)    272,222        2,110
Byron (Buzz) Moran            1997  130,000        0            0         8,000            0
Vice President of Research
 and                          1996  130,000   25,000       47,122(3)     11,722            0
Development and Operations    1995  130,000   25,000       40,927(3)    117,222            0
Paulita M. LaPlante           1997  121,000        0            0        15,000            0
Vice President of Worldwide
 Sales,                       1996  114,316   27,000            0         8,889            0
Marketing and Business
 Development                  1995   94,630   28,000            0        88,888            0
Wesley G. Peterson            1997   97,000        0            0         7,000            0
Chief Financial Officer,
 Vice President               1996   97,000   24,000            0         6,044            0
of Finance and Administra-
 tion                         1995   85,854   26,000            0        60,444            0
</TABLE>
- --------
(1) Consists of life insurance premiums paid by the Company on behalf of Mr.
    Humphries.
(2) Consists of a car allowance of $500 per month.
(3) Consists of amounts reimbursed by the Company for relocation and temporary
    living expenses.
 
OPTION GRANTS AND EXERCISES
 
  The following tables summarize option grants and exercises during the year
ended December 31, 1997 to or by the Named Executive Officers and the
potential realizable value of the options held by such persons at December 31,
1997.
 
                       OPTION GRANTS IN LAST FISCAL YEAR
<TABLE>
<CAPTION>
                                                                             POTENTIAL
                                                                          REALIZABLE VALUE
                                                                             AT ASSUMED
                                                                          ANNUAL RATES OF
                                                                            STOCK PRICE
                                                                          APPRECIATION FOR
                                      INDIVIDUAL GRANTS (1)                OPTION TERM(2)
                         ------------------------------------------------ ----------------
                          NUMBER OF
                         SECURITIES  PERCENT OF TOTAL EXERCISE
                         UNDERLYING  OPTIONS GRANTED  OR BASE
                           OPTIONS     TO EMPLOYEES    PRICE   EXPIRATION
NAME                     GRANTED (#)  IN FISCAL YEAR   ($/SH)     DATE      5%      10%
- ----                     ----------- ---------------- -------- ---------- ------- --------
<S>                      <C>         <C>              <C>      <C>        <C>     <C>
Sam B. Humphries........   25,000           21%        $4.875   6/11/07   $76,647 $194,237
Byron (Buzz) Moran......    8,000            7%         4.875   6/11/07    24,527   62,156
Paulita M. LaPlante.....   15,000           12%         4.875   6/11/07    45,988  116,543
Wesley G. Peterson......    7,000            6%         4.875   6/11/07    21,461   54,387
</TABLE>
- --------
(1) All of the options granted to executives were granted under the Company's
    1993 Stock Option Plan. The foregoing options become exercisable at the
    rate of 25% of the number of shares covered by such option on each of the
    first four anniversary dates of the grant of such option, so long as the
    executive remains employed by the Company or one of its subsidiaries. To
    the extent not already exercisable, options under the plan become
    immediately exercisable in full upon certain changes in control of the
    Company and remain exercisable for the remainder of their term. See
    "Executive Compensation and Other Benefits--Change in Control
    Arrangements."
(2) These amounts represent certain assumed rates of appreciation only. Actual
    gains, if any, on stock option exercises are dependent upon the future
    performance of the Company's Common Stock, overall market conditions and
    the executive's continued employment with the Company. The amounts
    represented in this table might not necessarily be achieved.
 
                                       7
<PAGE>
 
                        AGGREGATED OPTION EXERCISES IN
              LAST FISCAL YEAR AND FISCAL YEAR-END OPTION VALUES
 
<TABLE>
<CAPTION>
                               NUMBER OF SECURITIES
                              UNDERLYING UNEXERCISED     VALUE OF UNEXERCISED
                                    OPTIONS AT          IN-THE-MONEY OPTIONS AT
                                 DECEMBER 31, 1997       DECEMBER 31, 1997(1)
                             ------------------------- -------------------------
NAME                         EXERCISABLE UNEXERCISABLE EXERCISABLE UNEXERCISABLE
- ----                         ----------- ------------- ----------- -------------
<S>                          <C>         <C>           <C>         <C>
Sam B. Humphries............    6,805       45,417      $      0     $ 12,500
Byron (Buzz) Moran..........   26,374       63,682       104,912      213,833
Paulita M. LaPlante.........   64,444       48,333       278,443      126,830
Wesley G. Peterson..........   22,268       29,665        92,888       84,641
</TABLE>
- --------
(1) Value based on the difference between the fair market value of the Common
    Stock on December 31, 1997 ($5.375) and the exercise price of the options.
 
EMPLOYMENT AGREEMENT
 
  The Company entered into an Employment Agreement with Mr. Humphries in
October 1991. The agreement had an initial term through November 1992, and
provides for automatic renewal for additional one-year periods unless either
party gives notice of termination to the other not less than 60 days before
the expiration of the then current term. Mr. Humphries has a current base
salary of $185,000 per year, which may be increased by the Board of Directors,
and is entitled to receive an annual incentive bonus at the discretion of the
Board of Directors. Mr. Humphries also receives an automobile allowance of
$500 per month. The agreement requires Mr. Humphries to assign to the Company
patents and other proprietary rights related to the Company's business and to
keep the Company's proprietary information confidential. Mr. Humphries is also
prohibited from competing with the Company for a period of one year following
the termination of his employment with the Company.
 
  In connection with the employment agreement, the Company granted Mr.
Humphries stock options to purchase an aggregate of 121,162 shares of Common
Stock at a price of $9.00 per share, which would have vested at various times
through October 1, 1996. On August 2, 1995, the Board of Directors granted Mr.
Humphries a Non-Statutory Option to purchase 272,222 shares of Common Stock at
an exercise price of $0.90 per share expiring ten years after the grant date,
and canceled Mr. Humphries' prior options. This option was granted as part of
a grant of options to all employees of the Company at the same exercise price.
On September 1, 1995, Mr. Humphries exercised this option and paid for the
shares by executing a non-recourse promissory note in the amount of $245,000
in favor of the Company, which is secured by a pledge of the shares acquired.
A total of 81,666 shares are subject to forfeiture should Mr. Humphries'
employment with the Company terminate prior to August 2, 1999. The fair market
value of shares subject to the pledge must be at least 200% of the principal
amount of the note outstanding from time to time. The note bears interest at
the rate of 5.91% per year, which is payable, annually. The note becomes due
on August 1, 1998.
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
  John M. Nehra and Gary A. Peterson served as members of the Company's
Compensation Committee through November 1997. Effective December 1, 1997,
Richard J. Meelia was elected to the Compensation Committee, filling the
vacancy created when Mr. Nehra resigned from the Board. Mr. Nehra is the
Managing General Partner of Catalyst Ventures Limited Partnership, and Mr.
Peterson is a General Partner of PSF Advisors, the General Partner of PSF
Health Care Fund L.P., each of which is an investor in the Company. See
"Principal Stockholders and Beneficial Ownership of Management." Mr. Meelia is
the President and Chief Executive Officer of The Kendall Company. No other
relationships existed during 1997 with respect to Mr. Nehra, Mr. Peterson or
Mr. Meelia that would be required to be disclosed under the rules of the
Securities Act of 1933, as amended (the "Securities Act").
 
                                       8
<PAGE>
 
COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION
 
  The Compensation Committee consisted of John M. Nehra and Mr. Peterson from
January 1997 through November 1997. Effective December 1, 1997, Mr. Meelia was
elected to the Compensation Committee filling the vacancy created when Mr.
Nehra resigned from the Board in November 1997. Accordingly, the Compensation
Committee of the Board of Directors currently consists of Richard J. Meelia
and Gary A. Peterson. The Compensation Committee makes recommendations to the
Board of Directors concerning the compensation of the Company's directors,
executive officers and key managers, and acts on such other matters relating
to their compensation as it deems appropriate. In addition, the Compensation
Committee administers the Company's stock option plans, pursuant to which
incentive stock options and non-statutory stock options may be granted to
eligible key employees, officers, directors and consultants of the Company,
and the Company's Employee Stock Purchase Plan, pursuant to which employees of
the Company may purchase shares of Common Stock directly from the Company on
favorable terms through payroll deductions.
 
  COMPENSATION PHILOSOPHY AND OBJECTIVES. The philosophy underlying the
decisions and recommendations of the Compensation Committee is to recognize
and reward results and achievement at the Company and individual level by
linking compensation to such achievement. Consistent with this philosophy, the
Compensation Committee has set the following objectives for the Company's
executive compensation program:
 
  . Motivate officers to achieve desired Company performance goals by
    rewarding such achievements.
 
  . Provide a program of compensation that is competitive with comparable
    companies to enable the Company to attract and retain key executive
    talent.
 
  . Align the interests of the Company's executives with the interests of the
    Company's stockholders by linking compensation to the Company's
    performance and by providing the Company's executives with long-term
    opportunities for stock ownership.
 
  In determining its recommendations as to the compensation of the Company's
executives, the Compensation Committee considers factors such as Company
performance, both in isolation and in comparison to companies of comparable
development, complexity and size; the individual performance of each executive
officer; historical compensation levels at the Company; the overall
competitive environment for executives and the level of compensation necessary
to attract and retain the level of key executive talent desired by the
Company. The Compensation Committee places primary emphasis on Company
performance rather than individual performance as measured against goals
approved by the Compensation Committee. In analyzing these factors, the
Compensation Committee may from time to time review competitive compensation
data gathered in comparative surveys or collected by independent consultants.
 
  EXECUTIVE COMPENSATION PROGRAM COMPONENTS. The Company's executive
compensation program consists of base salary, annual cash performance bonuses,
and long-term incentive opportunities under the Company's stock option plans.
Each element of the compensation program is discussed in greater detail below.
 
    Base Salary. The Compensation Committee's recommendations regarding the
  base salary of each executive officer of the Company, including the
  compensation of Mr. Humphries as Chief Executive Officer, are based on a
  number of factors, including the executive officer's experience and
  qualifications, the potential impact of the individual on the Company's
  performance, the level of skill and responsibility required by the
  individual's position and the other factors described above. Base salaries
  are determined for each year prior to the beginning of the year. In
  general, the Compensation Committee seeks to set executive officer base
  salaries at moderately to
 
                                       9
<PAGE>
 
  aggressively competitive levels in relation to the companies with which the
  Company competes for executives. None of the Company's executive officers
  received a salary increase in 1997.
 
    Annual Management Performance Bonuses. The Company's annual management
  performance bonus program is designed to provide a direct financial
  incentive to the Company's executive officers, including the Chief
  Executive Officer, for the achievement of specific Company performance
  goals. Generally, at the beginning of each year, the Compensation Committee
  establishes a maximum annual bonus, as a percentage of base salary, that
  the Chief Executive Officer and the other executive officers of the Company
  are eligible to receive and the goals against which performance will be
  measured in determining annual bonuses after the conclusion of the year. In
  past years, these goals have consisted of financial and non-financial
  goals, established to motivate the executive officers to achieve milestones
  that would impact the Company's long-term value. Because of product issues
  that developed early in 1997 that prevented the Company from effectively
  selling its product during most of 1997, the Board did not anticipate that
  significant bonuses would be paid for 1997. Accordingly, formal performance
  goals were not established for 1997. Late in 1997, the Compensation
  Committee approved a relatively modest bonus for the Chief Executive
  Officer that was substantially less than bonuses paid to the Chief
  Executive Officer in prior years. No bonuses were paid to any of the other
  executive officers of the Company for 1997.
 
    Long-Term Incentive Compensation. The Compensation Committee makes long-
  term incentive compensation available to the Company's executive officers,
  as well as all other employees of the Company, through the grant of stock
  options. The purpose of stock option grants is to advance the interests of
  the Company and its stockholders by enabling the Company to attract and
  retain persons of ability to perform services for the Company, including
  persons performing services to the Company as executive officers. By
  granting stock options to executive officers and other employees, the
  Compensation Committee seeks to align the long-term interests of these
  individuals with those of the Company's stockholders by creating a strong
  and direct nexus between compensation and stockholder return and to enable
  executive officers and key managers to develop and maintain a significant
  ownership position in the Company. The Compensation Committee determines
  the number of options and the terms and conditions of such options based on
  certain factors, including the past performance of the executive officer,
  the executive officer's potential impact on the achievement of the
  Company's objectives, past grants or awards of stock-based compensation and
  on comparative compensation data regarding option grants by companies
  within the medical device industry as well as within a broader group of
  companies of comparable size and complexity. Additionally, options may be
  granted to an executive officer as an incentive at the time the executive
  officer joins the Company. All options granted by the Compensation
  Committee have an exercise price equal to 100% of the fair market value of
  the Common Stock on the date of grant. In general, options vest at the rate
  of 25% of the shares covered by the option each year over a period of four
  years and remain exercisable for a period of 10 years from the date of
  grant, provided the individual continues to be employed by the Company. In
  1997, the Compensation Committee granted options to all executive officers
  of the Company and key managers and sales personnel of the Company. The
  primary purpose of the 1997 stock option grants was to recognize the
  outstanding individual contributions being made by these individuals during
  a year in which the Company would likely not meet its sales or financial
  objectives.
 
  SECTION 162(M). Section 162(m) of the Internal Revenue Code of 1986, as
amended (the "Code"), limits the deductibility of certain compensation paid to
the chief executive officer and each of the four other most highly compensated
executives of a publicly held corporation to $1,000,000. In 1997, the Company
did not pay "compensation" within the meaning of Section 162(m) to such
executive officers in excess of $1,000,000, and does not believe it will do so
in the near future. Therefore, the Company does not have a policy at this time
regarding qualifying compensation paid to
 
                                      10
<PAGE>
 
its executive officers for deductibility under Section 162(m), but will
formulate such a policy if compensation levels ever approach $1,000,000.
 
                                          Compensation Committee
 
                                          Richard J. Meelia
                                          Gary A. Peterson
                                          John M. Nehra (former committee
                                           member)
 
COMPARATIVE STOCK PERFORMANCE
 
  The graph below compares, for the period from February 14, 1996, the date of
the Company's initial public offering, to December 31, 1997, the total
cumulative shareholder return on the Company's Common Stock to the total
cumulative return on the Standard & Poor's 500 Stock Index and a peer-group
selected in good faith by the Company consisting of the following companies:
Datascope Corporation; Diametrics Medical, Inc.; i-Stat Corporation; Marquette
Medical Systems, Inc.; Protocol Systems, Inc.; and Spacelabs Medical, Inc. The
peer group consists of public companies in the Company's industry that market
arterial blood gas measurement systems or critical care patient bedside
monitoring systems, and the peer-group companies were selected on that basis.
The graph assumes a $100 investment in the Company's Common Stock, the
Standard & Poor's 500 Stock Index and the peer-group on February 14, 1996 and
the reinvestment of all dividends. Nellcor Puritan Bennet Incorporated was
acquired in 1997 and is no longer included in the Company's peer group.
 
                                    [GRAPH]

                                        2/14/96         12/96       12/97
                                        -------         -----       -----
Optical Sensors Inc.                     $100           $ 62        $ 41
S & P 500 Index                          $ 89           $116        $155
Peer Group                               $ 62           $ 89        $ 91

 
                                      11
<PAGE>
 
CHANGE IN CONTROL ARRANGEMENTS
 
  Under the Company's 1993 Stock Option Plan, as amended (the "1993 Plan"),
upon the occurrence of a "change in control" all outstanding options granted
under the 1993 Plan will become and remain exercisable in full during their
remaining terms regardless of whether the plan participants thereafter remain
employees of the Company or a subsidiary. The acceleration of the
exercisability of options under the 1993 Plan may be limited, however, if the
acceleration would be subject to an excise tax imposed upon "excess parachute
payments." Under the 1993 Plan, a "change in control" has occurred in the
event of (a) the sale, lease, exchange or other transfer of all or
substantially all of the assets of the Company (in one transaction or in a
series of related transactions) to a corporation that is not controlled by the
Company; (b) the approval by the stockholders of the Company of any plan or
proposal for the liquidation or dissolution of the Company; (c) a change in
control of the Company of a nature that would be required to be reported
pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), whether or not the Company is then subject to
such reporting requirement; (d) any person becomes the "beneficial owner,"
directly or indirectly, of 50% or more of the combined voting power of the
Company's outstanding securities ordinarily having the right to vote at
elections of directors; or (e) individuals who constitute the board of
directors of the Company on the effective date of the 1993 Plan cease for any
reason to constitute at least a majority thereof, provided that any person
becoming a director subsequent to the effective date of the 1993 Plan whose
election, or nomination for election by the Company's stockholders, was
approved by a vote of at least a majority of the directors comprising the
board of directors of the Company on the effective date of the 1993 Plan
(either by a specific vote or by approval of the proxy statement of the
Company in which such person is named as a nominee for director, without
objection to such nomination) shall be considered as though such person were a
member of the board of directors of the Company on the effective date of the
1993 Plan. In addition, the Compensation Committee, with the consent of any
affected participant, may determine that some or all of the participants
holding outstanding options will receive cash in an amount equal to the excess
of the fair market value of such shares immediately before the effective date
of the change in control over the exercise price per share of the options. In
addition, certain forfeiture restrictions that apply to certain shares of
Common Stock currently held by Mr. Humphries would expire upon a change in
control as described above if Mr. Humphries employment with the Company was
terminated following such change in control.
 
                             CERTAIN TRANSACTIONS
 
  The Company has entered into an employment agreement and a related stock
option agreement covering 272,222 shares of Common Stock with Sam B.
Humphries, its Chief Executive Officer. On September 1, 1995, Mr. Humphries
exercised this option and paid for the shares by executing a non-recourse
promissory note in the amount of $245,000 in favor of the Company, which is
secured by a pledge of the shares acquired. The fair market value of shares
subject to the pledge must be at least 200% of the principal amount of the
note outstanding from time to time. The note bears interest at the rate of
5.91% per year, which is payable annually. The note becomes due on August 1,
1998. See "Executive Compensation and Other Benefits--Employment Agreement."
 
  Pursuant to a Registration Rights Agreement entered into prior to the
Company's initial public offering of Common Stock in February 1996, among the
Company and certain shareholders including Norwest Venture Capital, Trustees
of the General Electric Pension Trust and Coral Partners II, a limited
partnership, such shareholders have certain demand and incidental registration
rights with respect to shares of Common Stock held by such shareholders.
 
                                      12
<PAGE>
 
                         RATIFICATION OF SELECTION OF
                             INDEPENDENT AUDITORS
 
                                  PROPOSAL 2
 
  The Board of Directors has appointed Ernst & Young LLP, independent
certified public accountants, as auditors of the Company for the year ending
December 31, 1998. Such firm has acted as independent auditors of the Company
since the fiscal year ended December 31, 1989. Although it is not required to
do so, the Board wishes to submit the selection of Ernst & Young LLP to the
stockholders for ratification. If the stockholders do not ratify the
appointment of Ernst & Young LLP, another firm of independent auditors will be
considered by the Board of Directors. Representatives of Ernst & Young LLP
will be present at the Annual Meeting, will have an opportunity to make a
statement if they so desire and will be available to respond to appropriate
questions.
 
BOARD OF DIRECTORS RECOMMENDATION
 
  The Board of Directors recommends a vote FOR ratification of the appointment
of Ernst & Young LLP as auditors of the Company for the year ending December
31, 1998. The affirmative vote of the holders of a majority of shares of
Common Stock of the Company present in person or by proxy at the Annual
Meeting, assuming a quorum is present, is necessary for approval. Unless a
contrary choice is specified, proxies solicited by the Board of Directors will
be voted FOR the ratification of Ernst & Young LLP.
 
            SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
 
  Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
the Company's directors and executive officers and all persons who
beneficially own more than 10% of the outstanding shares of the Company's
Common Stock to file with the Securities and Exchange Commission initial
reports of ownership and reports of changes in ownership of the Company's
Common Stock. Executive officers, directors and greater than 10% beneficial
owners are also required to furnish the Company with copies of all Section
16(a) forms they file. To the Company's knowledge, based upon a review of the
copies of such reports furnished to the Company during the year ended December
31, 1997 and written representations by such persons, none of the directors,
officers and beneficial owners of greater than 10% of the Company's Common
Stock failed to file on a timely basis the forms required by Section 16 of the
Exchange Act.
 
                 STOCKHOLDER PROPOSALS FOR 1999 ANNUAL MEETING
 
  Proposals of stockholders intended to be presented in the proxy materials
relating to the next Annual Meeting must be received by the Company at its
principal executive offices by December 3, 1998.
 
                                 OTHER MATTERS
 
  The management of the Company does not intend to present other items of
business and knows of no items of business that are likely to be brought
before the Annual Meeting except those described in this Proxy Statement.
However, if any other matters should properly come before the Annual Meeting,
the persons named in the enclosed proxy will have discretionary authority to
vote such proxy in accordance with the best judgment on such matters.
 
                                      13
<PAGE>
 
                                 MISCELLANEOUS
 
  THE COMPANY WILL FURNISH WITHOUT CHARGE A COPY OF ITS ANNUAL REPORT ON FORM
10-K (EXCLUSIVE OF EXHIBITS) FOR THE FISCAL YEAR ENDED DECEMBER 31, 1997 TO
EACH PERSON WHO WAS A STOCKHOLDER OF THE COMPANY AS OF MARCH 13, 1998, UPON
RECEIPT FROM ANY SUCH PERSON OF A WRITTEN REQUEST FOR SUCH AN ANNUAL REPORT.
SUCH REQUEST SHOULD BE SENT TO: OPTICAL SENSORS INCORPORATED, 7615 GOLDEN
TRIANGLE DRIVE, SUITE A, MINNEAPOLIS, MINNESOTA 55344; ATTN: STOCKHOLDER
INFORMATION.
 
                                          BY ORDER OF THE BOARD OF DIRECTORS


                                          /s/ Sam B. Humphries
                                          Sam B. Humphries
                                          President and Chief Executive
                                          Officer
 
April 2, 1998
Minneapolis, Minnesota
 
                                      14
<PAGE>
 
                          OPTICAL SENSORS INCORPORATED
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
  The undersigned hereby appoints Sam B. Humphries and Wesley G. Peterson, and
each of them, as Proxies, each with full power to appoint his substitute, and
hereby authorizes each of them to represent and to vote, as designated below,
all the shares of Common Stock of Optical Sensors Incorporated held of record
by the undersigned on March 13, 1998, at the Annual Meeting of Stockholders to
be held on May 7, 1998, or any adjournment, thereof.
1. ELECTION OF DIRECTORS.
 [_] FOR all nominees listed below [_] AGAINST all nominees listed below
 (except as marked to the contrary below)
      Sam B. Humphries              Richard B. Egen       Richard J. Meelia
      Demetre M. Nicoloff, M.D.     Gary A. Peterson

(INSTRUCTION: TO VOTE AGAINST ANY INDIVIDUAL NOMINEE, STRIKE A LINE THROUGH THE
                                NOMINEE'S NAME.)
 
2. PROPOSAL TO RATIFY THE APPOINTMENT OF ERNST & YOUNG LLP AS INDEPENDENT
 AUDITORS FOR THE COMPANY FOR THE FISCAL YEAR ENDING DECEMBER 31, 1998.
 
                     [_] FOR    [_] AGAINST   [_] ABSTAIN
 
3. In their discretion, the Proxies are authorized to vote upon such other
business as may properly come before the meeting.
 
P
R
O
X
Y
  THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED
HEREIN BY THE UNDERSIGNED SHAREHOLDER. IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSAL 2 AND FOR ALL NOMINEES NAMED IN PROPOSAL 1 ABOVE. Please
sign exactly as name appears below. When shares are held by joint tenants, both
should sign. When signing as attorney, executor, administrator, trustee or
guardian, please give full title as such. If a corporation, please sign in full
corporate name by President or other authorized officer. If a partnership,
please sign in partnership name by authorized person.
 
                                           Dated: ____________, 1998
 
                                           ------------------------------------
                                                   Signature
 
                                           ------------------------------------
                                               Signature if held
                                                    jointly
 
 PLEASE MARK, SIGN, DATE AND RETURN THE PROXY CARD PROMPTLY USING THE ENCLOSED
      ENVELOPE, WHICH REQUIRES NO POSTAGE IF MAILED IN THE UNITED STATES.
 


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