SUGEN INC
10-Q, 1998-05-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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================================================================================

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                          -----------------------------

                                    FORM 10-Q
(Mark one)

   X        Quarterly report pursuant to Section 13 or 15(d)  of the  Securities
- -------     Exchange Act of 1934. For the quarterly period ended March 31, 1998.
            or
            Transition report  pursuant to Section 13 or 15(d) of the Securities
- -------     Exchange Act of 1934. For the transition period  from ___________ to
            ___________.


                             Commission File Number:
                                     0-24814

                          -----------------------------


                                   SUGEN, Inc.
             (Exact name of registrant as specified in its charter)

              Delaware                                   13-3629196
   (State or other jurisdiction of                    (I.R.S. Employer
   incorporation or organization)                     Identification No.)


               351 Galveston Drive, Redwood City, California 94063
                    (address of principal executive offices)

                                 (650) 306-7700
              (Registrant's telephone number, including area code)


                          -----------------------------


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required to file such reports),  and (2) has been subject to filing requirements
for the past 90 days. Yes  X  No
                          ---    ---

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest  practicable  date.  Common Stock $.01 par value;
15,419,267 shares outstanding at April 30, 1998.

================================================================================

<PAGE>



                                   SUGEN, Inc.

                                      INDEX

                                                                        PAGE NO.
                                                                        --------
PART I.  FINANCIAL INFORMATION

Item 1.           Financial Statements and Notes

                  Condensed Balance Sheets - March 31, 1998
                  and December 31, 1997                                     3

                  Statements of Operations - for the three
                  months ended March 31, 1998                               4

                  Condensed Statements of Cash Flows - for the three
                  months ended March 31, 1998 and 1997                      5

                  Notes to Financial Statements                             6

Item 2.           Management's Discussion and Analysis of Financial
                  Condition and Results of Operations                       8


PART II. OTHER INFORMATION

Item 6.           Exhibits and Reports on Form 8-K                          12


Signatures                                                                  13


Exhibit Index                                                               14

                                        2

<PAGE>


                          PART I. FINANCIAL INFORMATION

Item 1.   FINANCIAL STATEMENTS AND NOTES

                                   SUGEN, Inc.

                            CONDENSED BALANCE SHEETS
                                 (In thousands)


                                                          March 31, December 31,
                                                            1998        1997
                                                         ---------   ---------
ASSETS                                                  (unaudited)
Current assets:
        Cash and cash equivalents                        $  10,301   $  23,816
        Short-term investments                              57,978      51,479
        Accounts receivable                                    172         237
        Prepaid expenses and other current assets              917         754
                                                         ---------   ---------
              Total current assets                          69,368      76,286

Property and equipment, net                                  4,282       4,601
Other assets                                                 3,858       3,938
                                                         ---------   ---------
                                                         $  77,508   $  84,825
                                                         =========   =========

LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
        Accounts payable                                 $   2,527   $   1,991
        Accrued liabilities                                 10,531      10,267
        Deferred contract revenue                              625         625
        Capital lease obligations - current portion          2,332       2,277
                                                         ---------   ---------
              Total current liabilities                     16,015      15,160

Long-term liabilities:
        Capital lease obligations - non-current portion      3,412       3,152
        Senior custom convertible notes                     17,029      17,500
                                                         ---------   ---------
              Total long-term liabilities                   20,441      20,652

Stockholders' equity:

        Common stock                                       142,686     141,579
        Deferred compensation                                 (592)       (695)
        Note receivable from stockholder                      (883)       (883)
        Accumulated deficit                               (100,159)    (90,988)
                                                         ---------   ---------
              Total stockholders' equity                    41,052      49,013
                                                         ---------   ---------
                                                         $  77,508   $  84,825
                                                         =========   =========


                             See accompanying notes.

                                        3
<PAGE>

                                   SUGEN, Inc.

                            STATEMENTS OF OPERATIONS
                    (In thousands, except per share amounts)
                                   (unaudited)


                                                            Three Months Ended
                                                                 March 31,
                                                           --------------------
                                                             1998        1997
                                                           --------    --------

Contract revenue (includes amounts from
   related party)                                          $  1,645    $  1,487

Costs and expenses:
   Research and development                                   9,432       8,006
   General and administrative                                 1,845       1,478
                                                           --------    --------
      Total costs and expenses                               11,277       9,484
                                                           --------    --------

Operating loss                                               (9,632)     (7,997)

Other income and expenses:
   Interest income                                              979         693
   Interest expense                                            (468)       (170)
                                                           --------    --------
      Other income, net                                         511         523
                                                           --------    --------
Net loss                                                   $ (9,121)   $ (7,474)
                                                           ========    ========


Basic and diluted net loss per share                       $  (0.59)   $  (0.57)
                                                           ========    ========

Shares used in computing basic and diluted net loss
  per share                                                  15,345      13,022
                                                           ========    ========


                             See accompanying notes.

                                       4

<PAGE>


                                   SUGEN, Inc.

                       CONDENSED STATEMENTS OF CASH FLOWS
                Increase (decrease) in cash and cash equivalents
                                 (In thousands)
                                   (unaudited)

                                                             Three Months Ended
                                                                 March 31,
                                                            -------------------
                                                              1998       1997
                                                            --------   --------

Cash flows from operating activities
Net loss                                                    $ (9,121)  $ (7,474)
Adjustments to reconcile net loss to net cash provided
      (used) by operating activities:
      Depreciation and amortization                              958        739
      Deferred revenue                                          --           (5)
      Changes in operating assets and liabilities:
        Prepaid expenses and other current assets                (98)      (319)
        Other assets                                               1        (27)
        Accounts payable                                         536      1,286
        Accrued liabilities                                      265       (804)
                                                            --------   --------
Net cash used in operating activities                         (7,459)    (6,604)
                                                            --------   --------

Cash flows from investing activities
Sales/maturities (purchases) of short-term investments, net   (6,549)    (4,895)
Purchases of property and equipment, net                        (454)      (891)
                                                            --------   --------
Net cash used in investing activities                         (7,003)    (5,786)
                                                            --------   --------

Cash flows from financing activities
Proceeds from issuance of common stock, net                      632        351
Proceeds from lease financing of property and equipment          856      1,069
Payments under capital lease obligations                        (541)      (487)
                                                            --------   --------
Net cash provided by financing activities                        947        933
                                                            --------   --------

Net decrease in cash and cash equivalents                    (13,515)   (11,457)
Cash and cash equivalents at beginning of period              23,816     24,852
                                                            --------   --------
Cash and cash equivalents at end of period                  $ 10,301   $ 13,395
                                                            ========   ========


                             See accompanying notes.

                                        5
<PAGE>


                                   SUGEN, Inc.

                          NOTES TO FINANCIAL STATEMENTS

                                   (Unaudited)


1.       Summary of Significant Accounting Policies

         Basis of Presentation

         The  financial  information  at March 31, 1998 and for the three months
         ended March 31, 1998 and 1997 is unaudited but includes all adjustments
         (consisting only of normal  recurring  adjustments)  which SUGEN,  Inc.
         (the "Company")  considers  necessary for the fair  presentation of the
         financial  position  at such date and the  operating  results  and cash
         flows  for  those  periods.   The  accompanying   condensed   financial
         statements should be read in conjunction with the financial  statements
         and notes thereto for the year ended  December 31, 1997 included in the
         Company's  Form 10-K.  The results of the Company's  operations for any
         interim  period are not  necessarily  indicative  of the results of the
         Company's operations for a full fiscal year.

         First quarter adoption of Statement 130, Reporting Comprehensive Income

         In June 1997, the Financial Accounting Standards Board issued Statement
         of Financial  Accounting  Standards  No. 130,  Reporting  Comprehensive
         Income ("SFAS 130").  SFAS 130  establishes new rules for the reporting
         and  display  of  comprehensive  income  and its  components.  SFAS 130
         requires unrealized gains or losses on the Company's available-for-sale
         securities and foreign currency translation adjustment,  which prior to
         adoption  were  reported  separately  in  shareholders'  equity,  to be
         included in other comprehensive  income. The adoption by the Company of
         SFAS 130 on January 1, 1998 had no material impact on the Company's net
         income or shareholders' equity.


2.       Accrued Liabilities

         The components of accrued liabilities consist of the following:

                                                    March 31,     December 31,
                                                      1998           1997 
                                                    -------        -------
                                                        (In thousands)      
                                                                   
          Accrued research & development services   $ 5,795        $ 5,351
          Accrued compensation                          890          1,176
          Accrued professional fees                     763            859
          Other                                       3,083          2,881
                                                    -------        -------
                                                    $10,531        $10,267
                                                    =======        =======
                                                                   
 
                                        6
<PAGE>

                                   SUGEN, Inc.

                    NOTES TO FINANCIAL STATEMENTS (continued)

                                   (Unaudited)


3.       Research  and  Development   Collaboration  Agreements  -  ASTA  Medica
         Aktiengesellschaft

         In January 1998, the first  milestone in connection  with the Company's
         collaboration  with ASTA  Medica was  achieved  in the  Pan-Her  cancer
         program.  ASTA  Medica  exercised  its option to satisfy  its  $500,000
         milestone  obligation  through the  purchase of 18,665  shares of SUGEN
         Common  Stock at a price of $26.79  per  share,  of which the amount in
         excess of fair  market  value on the date of exercise  was  recorded as
         revenue.  Such amount net of royalties totaled $219,000 and is included
         in contract revenue.

4.       Senior Custom Convertible Notes

         In March 1998,  $472,500 of principal  and accrued and unpaid  interest
         relating to SUGEN's  outstanding  senior custom  convertible notes were
         converted  into 40,000  shares of Common Stock at a price of $11.81 per
         share.





                                        7


<PAGE>


                                   SUGEN, Inc.

Item 2.         MANAGEMENT'S DISCUSSION AND ANALYSIS
                OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

         In addition to historical  information  contained herein, the following
discussion contains words such as "intends," "believes," "anticipates," "plans,"
"expects" and similar expressions which are intended to identify forward-looking
statements  within the meaning of Section 27A of the  Securities Act of 1933, as
amended,  and Section 21E of the  Securities  Exchange Act of 1934,  as amended,
which are subject to the "safe harbor" created by those sections.  The Company's
actual  results  could  differ  materially  from the results  discussed in these
forward-looking  statements.  Factors  that could  cause or  contribute  to such
differences include the factors discussed below as well as the factors discussed
in the  Company's  Form 10-K for the year ended  December 31, 1997.  Readers are
cautioned not to place undue reliance on these forward-looking statements, which
speak only as of the date  hereof.  The  Company  undertakes  no  obligation  to
release the results of any revision to these  forward-looking  statements  which
may be made to reflect events or  circumstances  occurring after the date hereof
or to reflect the occurrence of unanticipated events.


Overview

         SUGEN was founded in July 1991 to  discover  and develop new classes of
small  molecule  drugs  which  target  specific  cellular  signal   transduction
pathways.  These  signalling  pathways  are involved in a variety of chronic and
acute  pathological  diseases,  including  cancer  and  diabetes  as  well as in
dermatologic,  ophthalmic,  neurologic and immune disorders.  The Company's most
advanced  product  candidate  is SU101,  a PDGF TK  signalling  antagonist.  The
Company has initiated a Phase III clinical trial for use of SU101 as a treatment
for refractory malignant glioma during the first quarter of 1998.  Additionally,
SUGEN currently has underway a Phase II study of SU101 in combination  with BCNU
in front-line glioma and another Phase II study of SU101 mono-therapy in hormone
refractory  prostate  cancer.  To date,  approximately  175 patients,  including
patients with brain,  ovarian,  prostate and non-small  cell lung cancers,  have
been treated with SU101 in nine  Company-sponsored  clinical trials. The Company
is also  conducting  its initial  Phase I clinical  trial for its second  cancer
product candidate, SU5416, a Flk-1/KDR TK antagonist which inhibits angiogenesis
(the  process by which blood  vessels are formed).  In addition,  the Company is
conducting  a Phase I clinical  trial for  SU5271,  an EGF  antagonist,  for the
treatment  of  psoriasis.  Through  March  31,  1998,  substantially  all of the
Company's  revenue  apart from  interest  income  has been  earned  pursuant  to
collaborations  with Zeneca Limited ("Zeneca"),  ASTA Medica  Aktiengesellschaft
("ASTA Medica") and Vision Pharmaceuticals L.P., an affiliate of Allergan, Inc.,
and Allergan, Inc. (collectively "Allergan").  The Company intends to pursue its
cancer drug discovery  programs  independently in North America and its programs
in  other  disease  areas  in  collaboration  with  established   pharmaceutical
companies.

         The  Company has not been  profitable  since  inception  and expects to
incur  substantial  losses  for the  foreseeable  future,  primarily  due to the
expansion of  preclinical  and clinical  development  activities  as more of its
proprietary  cancer-related  programs  progress toward and into the clinic.  The
Company expects that losses will fluctuate from quarter to quarter and that such
fluctuations may be substantial. As of March 31, 1998, the Company's accumulated
deficit was $100.2 million.

Results of Operations


                                       8
<PAGE>

         The  Company's  revenues  for the three months ended March 31, 1998 and
1997 were $1.6 million and $1.5  million,  respectively.  Revenues for the three
months  ended March 31, 1998  included  contract  revenue  from the Allergan and
Zeneca  collaborations  and a milestone  earned in connection with the Company's
collaboration  with ASTA  Medica.  In addition to Allergan  and Zeneca  contract
revenue,  1997 revenues included contract services revenue earned under the ASTA
Medica  collaboration  for  services  provided  by ASTA  Medica  pursuant to the
collaboration but on  non-collaboration  programs.  The Company expects to fully
utilize the remaining  available credit for contract  services  provided by ASTA
Medica by the end of 1998, and thereafter will only recognize  revenue under the
ASTA Medica collaboration upon the achievement of specified milestones.

         Research and development  expenses for the three months ended March 31,
1998 and 1997 were $9.4  million and $8.0  million,  respectively.  The increase
during 1998 was primarily due to higher personnel  related costs associated with
the expansion of the Company's research and development  programs.  In addition,
the progression of clinical  activities,  including  expanded Phase II and Phase
III  studies  of  the  Company's  lead  anti-cancer  compound,  SU101,  and  the
initiation of Phase I studies of the Company's second cancer product  candidate,
SU5416, contributed to higher expenses during 1998. The Company expects that its
research and  development  expenses will continue to grow in future years due to
the hiring of personnel,  additional  preclinical  studies,  the  progression of
SU101 and SU5416  clinical  trials,  the  initiation  of new clinical  trials on
additional drug candidates and research and development  activities  pursuant to
the Company's responsibilities under anticipated future collaborations.

         General and  administrative  expenses  for the three months ended March
31, 1998 and 1997 were $1.8 million and $1.5 million, respectively. The increase
in  1998  was  primarily  due to  higher  headcount  related  costs  as  well as
additional  expenses in the areas of  corporate  and business  development.  The
Company  expects that its general and  administrative  expenses will continue to
increase in order to support the Company's  expanding  research and  development
efforts.

         Interest income for the three months ended March 31, 1998 and 1997 were
$979,000 and $693,000,  respectively. This increase was due to higher investment
balances  arising  primarily from  issuances of the Company's  capital stock and
convertible debt. Interest expense for the three months ended March 31, 1998 and
1997 were $468,000 and $170,000,  respectively.  This increase was primarily due
to the  Company's  continued  use of capital  lease  financing for equipment and
property  improvements  and expenses  related to the  issuance of senior  custom
convertible  notes.  The Company expects that interest  expense will continue to
increase in future years due to the continued use of capital lease financing for
equipment and facility improvements.

Liquidity and Capital Resources

         At  March  31,  1998,  the  Company  had  cash,  cash  equivalents  and
short-term   investments   of   approximately   $68.3   million   compared  with
approximately  $75.3  million at December  31,  1997.  The  decrease in cash and
investments  during the three months ended March 31, 1998 was  primarily  due to
the net loss for the quarter.

         Through March 31, 1998,  the Company's  principal  sources of financing
have been its initial and follow-on public offerings of Common Stock, placements
of the Company's Preferred and Common Stock and senior custom convertible notes,
and funds received under the Company's corporate  collaborations.  The Company's
current  principal  sources  of  liquidity  are  its  research  and  development
collaborations with Zeneca, Allergan and ASTA Medica, its cash, cash equivalents
and

                                       9
<PAGE>

short-term  investments  and capital  lease  financing.  At March 31, 1998,  the
Company had  combined  capital  lease lines of $5.6  million  available  for the
purchase of equipment and facility improvements.

         The Company has entered into license and  research  agreements  whereby
the Company funds research projects performed by others or in-licenses compounds
from third  parties.  Some of the  agreements  may  require  the Company to make
milestone and royalty payments.  Under these programs,  commitments for external
research funding are approximately $1.7 million,  $1.6 million, $1.4 million and
$1.1  million  in  1998,  1999,  2000  and  2001,  respectively.  Most of  these
commitments  are  cancelable  within a  three-to-six  month period and limit the
amounts  payable by the Company for sponsored  research under the programs after
notice of cancellation.

         From time to time,  the  Company  evaluates  potential  investments  in
complementary  businesses,  products or technologies.  Currently, the Company is
considering modest investments in such complementary businesses during 1998. The
Company  has no other  present  undertakings,  commitments  or  agreements  with
respect to investments in other businesses.

         Net  additions of equipment and  leasehold  improvements  for the three
months ended March 31, 1998 and 1997 were $454,000 and  $891,000,  respectively.
The decrease in capital additions during the first quarter of 1998 from the same
period last year was  primarily  due to the timing of  equipment  purchases  and
facility  improvements.  Capital  additions  during  the first  quarter  of 1997
primarily  included the costs  associated  with the initial  phases of a limited
facility   expansion  and  continued   investment  in  enhancing  the  Company's
laboratory capabilities. The Company expects that its capital additions for 1998
will be higher than that of the prior year primarily due to anticipated facility
improvements in connection with the build-to-suit facility lease agreement which
was entered into in June 1997.  Construction of the new facility is targeted for
completion  during  the  fourth  quarter  of  1998,  which  coincides  with  the
expiration of the Company's  current facility  leases.  Although the Company has
not  expended  significant  amounts to date,  the  Company  expects to invest in
facility improvements and incur move related costs during the course of the year
as it  approaches  building  completion.  Accordingly,  it is expected  that the
Company's capital lease obligations and related interest expense, as well as its
depreciation expense, will increase in future periods.

         The Company estimates that its existing capital resources together with
facility and equipment financing,  expected revenues from current collaborations
and net  income  from  investment  activities,  will be  sufficient  to fund its
planned  operations  into  2000.  However,  there can be no  assurance  that the
underlying assumed levels of revenue and expense will prove accurate. Whether or
not these  assumptions  prove to be  accurate,  the  Company  will need to raise
substantial  additional  capital to fund its operations.  The Company intends to
seek such  additional  funding  through  collaborative  arrangements,  public or
private equity or debt financings and capital lease transactions; however, there
can be no assurance  that  additional  financing will be available on acceptable
terms, or at all. If additional  funds are raised by issuing equity  securities,
further  dilution to  stockholders  may result.  In addition,  in the event that
additional funds are obtained through arrangements with collaborative  partners,
such arrangements may require the Company to relinquish rights to certain of its
technologies,  product  candidates or products that the Company would  otherwise
seek to develop or  commercialize  itself.  If adequate funds are not available,
the Company may be required to delay,  reduce the scope of or  eliminate  one or
more of its  research  or  development  programs,  which  could  have a material
adverse effect on the Company.

         The Year 2000 Issue is the result of computer  programs  being  written
using two digits  rather than four  digits to define the  applicable  year.  The
Company has reviewed its existing software programs for Year 2000 compliance and
believes  that  all  of  its  internal  application  systems  are 

                                       10
<PAGE>

currently  in  compliance.  The Company is in the process of  initiating  formal
communications with all of its significant  suppliers to determine the extent to
which the Company is  vulnerable  to those third  parties'  failure to remediate
their own Year 2000  Issues.  The project is  estimated to be completed by early
1999,  which is prior to any anticipated  impact on its operations.  The Company
does not expect the costs of Year 2000  compliance to have a material  impact on
the Company's  financial results.  However,  there can be no assurance as to the
effect on the  Company of the  failure of third  parties,  with whom the Company
works, to achieve Year 2000 compliance on a timely basis.

         The Company is at an early stage of  development  and must be evaluated
in light of the  uncertainties  and  complications  present  in a  biotechnology
company.  The  Company has been in  existence  only since 1991 and to date three
drug candidates  (SU101,  SU5271 and SU5416) have entered  clinical  trials.  To
achieve profitable operations on a continuing basis, the Company,  alone or with
collaborative  partners, must successfully develop,  manufacture,  introduce and
market its proposed  products.  Products,  if any,  resulting from the Company's
research and development programs are not expected to be commercially  available
for several more years, even if they are developed successfully and proven to be
safe and effective.  The Company has experienced  significant  operating  losses
since its inception.  The Company expects to incur significant  operating losses
at least for the next several years and expects cumulative losses to increase as
the  Company's  research and  development  efforts,  including  preclinical  and
clinical testing,  are expanded.  Substantially all of the Company's revenues to
date have been  received  pursuant to the Company's  collaborations.  Should the
Company or its collaborators fail to perform in accordance with the terms of any
of their  agreements,  any consequent loss of revenue under the agreements could
have a material adverse effect on the Company's  results of operations.  Many of
the  Company's  currently  proposed  products  are  subject to  development  and
licensing arrangements with the Company's collaborators.  Therefore, the Company
is dependent on the research and development efforts of these collaborators with
respect to some of its proposed  products  and is entitled  only to a portion of
the revenues,  if any, realized from the commercial sale of any of the potential
products covered by the collaborations in many  jurisdictions.  Before obtaining
regulatory  clearance  for  the  commercial  sale of any of its  products  under
development,  the  Company  must  demonstrate  through  preclinical  studies and
clinical  trials that the potential  product is safe and  efficacious for use in
humans for each target  indication.  The failure to adequately  demonstrate  the
safety and  efficacy  of a product  under  clinical  development  could delay or
prevent regulatory  clearance of the potential product and could have a material
adverse effect on the Company.  The foregoing  risks reflect the Company's early
stage of  development  and the nature of the  Company's  industry and  potential
products.  Also inherent at the Company's  stage of  development  are a range of
additional risks,  including  uncertainties  regarding protection of patents and
proprietary  rights,  government  regulation,   competition,   employee  issues,
manufacturing   uncertainties,   the  Company's  lack  of  sales  and  marketing
capabilities,  uncertainty of market acceptance of the Company's  products,  and
uncertainties regarding pharmaceutical pricing and reimbursement.

                                       11

<PAGE>


                           PART II. OTHER INFORMATION


Item 4.       SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

              None.

Item 6.       EXHIBITS AND REPORTS ON FORM 8-K

(a)        Exhibits

Exhibit Number                      Description
- --------------                      -----------

         3.1             Restated Certificate of Incorporation (2)
         3.2(ii)         Bylaws of the Registrant (1)
         3.3             Certificate   of   Designation   of   Series  A  Junior
                         Participating Preferred Stock of the Registrant (3)
         10.70           Common  Stock  Purchase  Agreement,  dated  January 12,
                         1998,   between   the   Registrant   and  Asta   Medica
                         Aktiengesellschaft.
         10.71+          First Amendment to Lease, dated March 18, 1998, between
                         the  Registrant  and  Britannia  Pointe  Grand  Limited
                         Partnership.
         27              Financial Data Schedule


- ------------------
         +          The  Registrant  has requested  confidential  treatment with
                    respect to portions of this Exhibit.
         (1)        Incorporated by reference to identically  numbered  exhibits
                    filed in response  to Item 16  "Exhibits"  of the  Company's
                    Registration  Statement on Form S-1, as amended (File Number
                    33-77074), which became effective October 4, 1994.
         (2)        Incorporated by reference to identically  numbered  exhibits
                    filed in response  to Item 14  "Exhibits"  of the  Company's
                    Annual  Report of Form 10-K for the year ended  December 31,
                    1994.
         (3)        Filed as an exhibit  to the Form 8-K  Current  Report  dated
                    July 26, 1995 and incorporated herein by reference.


(b)      Reports on Form 8-K

         No reports on Form 8-K were filed  during the  quarter  ended March 31,
         1998.


                                       12

<PAGE>



                                   SIGNATURES

Pursuant to the  requirements  of the  Securities  and Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.


Date:    May 13, 1998                          SUGEN, Inc.
         ------------



By:    /s/ Stephen Evans-Freke                 By:  /s/ Susan M. Kanaya
       ------------------------------------         ---------------------------
       Stephen Evans-Freke                          Susan M. Kanaya
       Chairman of the Board and                    Treasurer
       Principal Executive and Financial            Principal Accounting Officer
       Officer





                                       13
<PAGE>


                                   SUGEN, Inc.

                                  EXHIBIT INDEX


Exhibit Number                      Description
- --------------                      -----------

         3.1             Restated Certificate of Incorporation (2)
         3.2(ii)         Bylaws of the Registrant (1)
         3.3             Certificate   of   Designation   of   Series  A  Junior
                         Participating Preferred Stock of the Registrant (3)
         10.70           Common  Stock  Purchase  Agreement,  dated  January 12,
                         1998,   between   the   Registrant   and  Asta   Medica
                         Aktiengesellschaft.
         10.71+          First Amendment to Lease, dated March 18, 1998, between
                         the  Registrant  and  Britannia  Pointe  Grand  Limited
                         Partnership.
         27              Financial Data Schedule


- ---------------------
         +          The  Registrant  has requested  confidential  treatment with
                    respect to portions of this Exhibit.
         (1)        Incorporated by reference to identically  numbered  exhibits
                    filed in response  to Item 16  "Exhibits"  of the  Company's
                    Registration  Statement on Form S-1, as amended (File Number
                    33-77074), which became effective October 4, 1994.
         (2)        Incorporated by reference to identically  numbered  exhibits
                    filed in response  to Item 14  "Exhibits"  of the  Company's
                    Annual  Report of Form 10-K for the year ended  December 31,
                    1994.
         (3)        Filed as an exhibit  to the Form 8-K  Current  Report  dated
                    July 26, 1995 and incorporated herein by reference.



                                       14



                                    AGREEMENT

                       for the purchase of Common Stock of

                                   SUGEN, INC.

                                       by

                         ASTA MEDICA AKTIENGESELLSCHAFT


<PAGE>
<TABLE>

                                TABLE OF CONTENTS
<CAPTION>
                                                                                                               Page

<S>      <C>                                                                                                      <C>
1.       PURCHASE AND SALE OF COMMON STOCK......................................................................  1
         1.1      Issue of Common Stock.........................................................................  1

2.       CLOSING DATE; DELIVERY.................................................................................  1
         2.1      Closing.......................................................................................  1
         2.2      Payment and Delivery..........................................................................  1

3.       REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY...............................................  2
         3.1      Organization..................................................................................  2
         3.2      Authority.....................................................................................  2
         3.3      Issuance of the Shares........................................................................  2
         3.4      Registration Rights Covenant..................................................................  2

4.       REPRESENTATIONS, WARRANTIES AND COVENANTS OF PURCHASER.................................................  6
         4.1      Legal Power...................................................................................  6
         4.2      Due Execution.................................................................................  6
         4.3      Investment Representations and Covenants......................................................  6
         4.4      Standstill Covenant...........................................................................  7
         4.5      Lockup Covenant...............................................................................  8

5.       CONDITIONS TO CLOSING..................................................................................  8
         5.1      Conditions to Obligations of Purchaser........................................................  8
                  (a)      Representations and Warranties True; Performance of Obligations......................  8
                  (b)      Proceedings and Documents............................................................  8
         5.2      Conditions to Obligations of the Company......................................................  8
                  (a)      Representations and Warranties True..................................................  9
                  (b)      Performance of Obligations...........................................................  9
                  (c)      Qualifications, Legal Investment.....................................................  9

6.       MISCELLANEOUS..........................................................................................  9
         6.1      Governing Law.................................................................................  9
         6.2      Successors and Assigns........................................................................  9
         6.3      Entire Agreement..............................................................................  9
         6.4      Separability................................................................................... 10
         6.5      Amendment and Waiver........................................................................... 10
         6.6      Notices........................................................................................ 10

                                       i
<PAGE>
                                TABLE OF CONTENTS
                                  (continued)

                                                                                                                 Page

         6.7      Fees and Expenses.............................................................................. 10
         6.8      Titles and Subtitles........................................................................... 10
         6.9      Counterparts................................................................................... 10
         6.10     Consent to Jurisdiction and Venue.............................................................. 10
</TABLE>
                                       ii

<PAGE>

                         COMMON STOCK PURCHASE AGREEMENT


         THIS COMMON STOCK PURCHASE AGREEMENT (the "Agreement) is made as of the
12th day of January,  1998, by and between SUGEN,  INC., a Delaware  corporation
(the  "Company"),  and ASTA  MEDICA  AKTIENGESELLSCHAFT,  a  German  corporation
("Purchaser").  Pursuant to that certain  letter dated December 5, 1995 from the
Company  to   Purchaser,   and  in   consideration   of  the  mutual   promises,
representations,  warranties  and conditions  set forth in this  Agreement,  the
Company and Purchaser agree as follows:

1.       PURCHASE AND SALE OF COMMON STOCK.

         1.1  Issue of Common Stock.

                  (a) The Company has  authorized the issuance and sale of up to
18,665 shares (the  "Shares") of its common  stock,  $.01 par value (the "Common
Stock").

                  (b)  In  reliance   upon   Purchaser's   representations   and
warranties contained in Section 4 hereof and subject to the terms and conditions
set forth  herein,  the Company  agrees to sell to Purchaser  the Shares,  to be
issued and sold at a price per share equal to two hundred  percent (200%) of the
Fair Market Value  thereof.  For purposes of this  Agreement,  Fair Market Value
shall  equal the  average  closing  sales  price of a share of  Common  Stock as
reported  for the  Nasdaq  National  Market for the twenty  (20)  business  days
preceding January 12, 1998.

                  (c) In reliance upon the representations and warranties of the
Company  contained  in Section 3 hereof and subject to the terms and  conditions
set forth  herein,  Purchaser  hereby  agrees to purchase  the Shares at the per
share purchase price set forth above.

2.   CLOSING DATE; DELIVERY.

         2.1  Closing.  The closing of the sale and purchase of the Shares under
this Agreement  (the  "Closing")  shall be held on or about 10:00 a.m.  (Pacific
Standard Time) on or about January 28, 1998 (the "Closing Date"), at the offices
of Cooley  Godward LLP, Five Palo Alto Square,  3000 El Camino Real,  Palo Alto,
California,  or at such other time and place as the  Company and  Purchaser  may
agree.  At the Closing,  the Company  will issue and sell,  and  Purchaser  will
purchase, the Shares for an aggregate purchase price of $499,990.55.

         2.2  Payment and  Delivery.  At the  Closing,  subject to the terms and
conditions  hereof,  the Company will deliver to Purchaser a stock  certificate,
registered in the name of

                                       1.
<PAGE>

Purchaser,  representing  the  Shares  to be  purchased  by  Purchaser  from the
Company, dated as of the Closing, against payment of the purchase price therefor
by wire  transfer,  unless other means of payment shall have been agreed upon by
Purchaser and the Company.

3. REPRESENTATIONS,  WARRANTIES AND COVENANTS OF THE COMPANY.

         The Company  hereby  represents  and  warrants to  Purchaser  as of the
Closing Date as follows:

         3.1  Organization.  The Company is a  corporation,  duly  incorporated,
validly  existing and in good standing under the laws of the jurisdiction of its
incorporation.

         3.2  Authority.  The Company has all  requisite  power and authority to
enter into this  Agreement,  and to  consummate  the  transactions  contemplated
hereby. The execution and delivery of this Agreement and the consummation of the
transactions  contemplated  hereby have been duly  authorized  by all  necessary
corporate action on the part of the Company,  and upon execution and delivery by
the Company,  this Agreement will  constitute a valid and binding  obligation of
the  Company,  enforceable  against  the Company in  accordance  with its terms,
subject to applicable  bankruptcy,  insolvency,  reorganization,  moratorium and
similar  laws  relating to or affecting  creditor's  rights from time to time in
effect, and subject to general equity principles.

         3.3  Issuance of the Shares.  The Shares,  when issued  pursuant to the
terms of this Agreement,  will be duly and validly authorized and issued,  fully
paid and nonassessable.


                                       2.
<PAGE>

         3.4      Registration Rights Covenant.

                  (a)  At  any  time  during  the  180-day  period   immediately
following the  termination  of the Screening  Period (as defined in that certain
Collaboration  Agreement  between the Company and Purchaser dated as of December
5, 1995 (the  "Collaboration  Agreement")),  Purchaser  shall  have the right to
cause the Company to file a registration  statement  under the Securities Act of
1933, as amended (the  "Securities  Act"), for a public offering of no less than
250,000 shares of Common Stock  beneficially  owned by Purchaser,  provided that
such shares include all of the Shares,  by delivering  written notice thereof to
the Company  specifying the number of Shares to be included in such registration
and the intended method of distribution  thereof (the  "Registration  Request").
Upon receipt of the Registration Request, the Company shall, as expeditiously as
possible,  use its best efforts to promptly  effect the  registration  under the
Securities  Act,  and  all  applicable  state  securities  laws,  to the  extent
necessary to permit the sale or other  disposition by Purchaser of the Shares to
be so registered in accordance with such notice.

                  (b) The demand  registration  rights granted in Section 3.4(a)
are subject to the following limitations: (i) the Company shall not be obligated
to effect  more than one  registration  pursuant  to  Section  3.4(a),  (ii) the
Company  shall not be obligated to effect such  registration  for a period of 60
days following the closing of an  underwritten  public offering of the Company's
equity  securities  that is in  registration  at the time of the  receipt of the
Registration Request (provided that the period within which Purchaser may demand
registration  hereunder  will be  extended  by the  number  of days by which the
registration  requested by Purchaser is delayed pursuant to this sentence);  and
(iii) if the Company  shall  furnish to  Purchaser a  certificate  signed by the
Chairman of the Board of Directors of the Company stating that in the good faith
judgment  of the  Board of  Directors  of the  Company,  it  would be  seriously
detrimental  to the Company and its  stockholders  for such  registration  to be
effected at such time, then the Company shall have the right to defer the filing
of the  registration for a period of not more than 180 days after receipt of the
Registration Request (provided that the period within which Purchaser may demand
registration  hereunder  will be  extended  by the  number  of days by which the
registration requested by Purchaser is delayed pursuant to this sentence).

                  (c) If and when the Company is required by the  provisions  of
Section  3.4(a)  to  include  all of the  Shares  in a  registration  under  the
Securities  Act,  Purchaser  will  furnish in  writing  such  information  as is
reasonably requested by the Company for inclusion in the registration  statement
relating to such offering and such other  information and  documentation  as the
Company shall  reasonably  request,  and the Company will, as  expeditiously  as
possible:

                           (i) Prepare and file with the Securities and Exchange
Commission 

                                       3.
<PAGE>

("SEC") a  registration  statement  with respect to such  securities and use its
best efforts to cause such  registration to become and remain effective for such
period as may be necessary to permit the successful marketing of such securities
but not exceeding 120 days (excluding any period during which a stop order is in
effect).

                           (ii)  Prepare  and file with the SEC such  amendments
and  supplements  to such  registration  statement  and the  prospectus  used in
connection  therewith as may be necessary to comply with the  provisions  of the
Securities Act and to keep such registration statement effective for that period
of time specified in paragraph (i) of this section.

                           (iii)   Furnish   to   Purchaser   such   number   of
prospectuses and preliminary prospectuses in conformity with the requirements of
the  Securities  Act, and such other  documents as such Purchaser may reasonably
request in order to  facilitate  the  public  sale or other  disposition  of the
Shares registered hereunder.

                           (iv) Use its best  efforts to register or qualify the
Shares covered by such  registration  statement  under such other  securities or
blue sky laws of such jurisdictions as Purchaser shall reasonably request and do
any and all other acts and things  which may be necessary or desirable to enable
Purchaser  to  consummate   the  public  sale  or  other   disposition  in  such
jurisdictions  of the Shares covered by such  registration  statement,  provided
that the Company shall not be required in connection therewith or as a condition
thereto  to qualify to do  business  or to file a general  consent to service of
process in any such states or jurisdictions.

                  (d) In the event of a registration  of any of the Shares under
the Securities Act pursuant to Section 3.4(a) in connection with an underwritten
public offering,  the Company will enter into and perform its obligations  under
an  underwriting  agreement,  in usual and  customary  form,  with the  managing
underwriters of such offering,  including without limitation providing usual and
customary  indemnification.  In the event  Purchaser  proposes to sell Shares in
accordance with this Section pursuant to an underwritten  offering,  the Company
shall have the right to approve the  managing  underwriters  for such  offering;
provided,  however,  that  such  approval  shall not be  unreasonably  withheld.
Purchaser will also provide usual and customary  indemnification  to the Company
and its affiliates with respect to claims,  losses and damages arising out of or
based on any untrue  statement (or alleged untrue  statement) of a material fact
contained in any registration  statement,  prospectus or other document,  or any
omission (or alleged  omission) to state  therein a material fact required to be
stated  therein or  necessary  to make the  statements  therein not  misleading;
provided,  however,  that in no event  shall any  indemnity  under this  Section
3.4(d) exceed the gross proceeds from the offering received by Purchaser.

                  (e) At any time or from time to time following  termination of
the Screening 

                                       4.
<PAGE>

Period  (as  defined  in the  Collaboration  Agreement),  if the  Company  shall
determine  to register any of its  securities  either for its own account or the
account  of a security  holder or holders  exercising  their  respective  demand
registration rights (other than pursuant to Section 3.4(a) hereof), other than a
registration  relating  solely to  employee  benefit  plans,  or a  registration
relating solely to a Rule 145 transaction, or a registration on any registration
form that does not permit secondary sales, then the Company will:

                           (i)  promptly  give to  Purchaser  a  written  notice
thereof; and

                           (ii)  use  its  best   efforts  to  include  in  such
registration  (and  any  related  qualification  under  blue  sky  laws or other
compliance),   except  as  set  forth  in  Section  3.4(f)  below,  and  in  any
underwriting  involved therein, all the Shares specified in a written request or
requests made by Purchaser  and received by the Company  within twenty (20) days
after the  written  notice  from the  Company  described  in clause (i) above is
mailed or delivered by the Company.

                  (f) If the  registration  of which the Company gives notice to
Purchaser is for a registered  public offering  involving an  underwriting,  the
Company shall so advise Purchaser as a part of the written notice given pursuant
to Section  3.4(e)(i).  In such event,  the right of Purchaser  to  registration
pursuant to Section 3.4(e) shall be conditioned upon  Purchaser's  participation
in such underwriting and the inclusion of Purchaser's Shares in the underwriting
to the extent  provided  herein.  Purchaser shall (together with the Company and
the other  holders of  securities  of the Company  with  registration  rights to
participate  therein  distributing  their securities  through such underwriting)
enter into an underwriting  agreement in customary form with the  representative
of the underwriter or underwriters selected by the Company.

         Notwithstanding  any other  provision of Sections 3.4(e) or (f), if the
representative of the underwriters advises the Company in writing that marketing
factors  require a limitation  on the number of shares to be  underwritten,  the
representative  may (subject to the  limitations  set forth  below)  exclude all
Shares from,  or limit the number of Shares to be included in, the  registration
and  underwriting.  The Company  shall so advise  Purchaser and other holders of
securities requesting  registration,  and the number of shares that are entitled
to be included in the registration and underwriting  shall be allocated first to
the Company for  securities  being sold for its own account and  thereafter  the
number of shares that are entitled to be included in the  registration  shall be
allocated among Purchaser and other holders requesting  inclusion of shares on a
pro rata basis,  subject to any prior agreements among the Company and its other
stockholders,  but only to the extent  that such other  agreements  provide  for
additional  limitations on the number of shares such other  stockholders  or the
Company will be entitled to include in the registration, which agreements are in
effect as of the date hereof. If Purchaser or any other person does not

                                       5.
<PAGE>

agree to the terms of any such underwriting, Purchaser and any other such person
shall  be  excluded  therefrom  by  written  notice  from  the  Company  or  the
underwriter.  Any Shares or other  securities  excluded or  withdrawn  from such
underwriting shall also be withdrawn from such registration.

                  (g) As used  herein,  "Registration  Expenses"  shall mean all
expenses incurred by the Company in complying with this Section 3.4,  including,
without  limitation,  all registration,  qualification and filing fees; printing
expenses;  fees and  disbursements  of counsel for the Company (and the fees and
disbursements  of  counsel  for the  Company in its  capacity  as counsel to the
Purchaser hereunder;  if Company counsel does not make itself available for this
purpose,  the Company  will pay the  reasonable  fees and  disbursements  of one
counsel  for the  Purchaser  as  selected  by  Purchaser)  and of the  Company's
independent accounting firm; blue sky fees and expenses;  underwriting discounts
and commissions and the expense of any special audits incident to or required by
any such  registration  (but excluding the compensation of regular  employees of
the Company which shall be paid in any event by the Company). Purchaser will pay
all Registration  Expenses in connection with a registration pursuant to Section
3.4(a) hereof;  provided,  however,  that in the event of a registration  of the
Shares pursuant to Section 3.4(a) either as a result of a material breach of the
Collaboration  Agreement  by the Company or the  inability  to replace a Project
pursuant  to  Section  2.6  of  the  Collaboration  Agreement,  or if  Purchaser
withdraws its demand for registration after having learned of a material adverse
change in the condition,  business,  or prospects of the Company from that known
to Purchaser at the time of its demand (in which case Purchaser shall retain its
rights pursuant to Section 3.4(a)), all Registration  Expenses shall be borne by
the Company.  All  Registration  Expenses in  connection  with any  registration
pursuant  to Section  3.4(e)  hereof  shall be borne by the  Company;  provided,
however,  that any incremental expenses incurred by the Company solely by reason
of Purchaser's  exercise of registration rights pursuant to Section 3.4(e) shall
be borne by the Purchaser.

                  (h) The rights conferred upon Purchaser under this Section 3.4
may be assigned by Purchaser to any permitted transferee of the Shares, provided
that each such transfer  complies with Section 4.5 and provided,  further,  that
only Purchaser  shall be authorized to give notice to the Company of any request
for registration  under this Section 3.4(a) and only Purchaser shall be entitled
to receive notice pursuant to Section 3.4(a) hereof.

4.  REPRESENTATIONS,  WARRANTIES AND COVENANTS OF PURCHASER.

         Purchaser hereby represents, warrants and covenants with the Company as
follows:

         4.1 Legal Power.  Purchaser  has the requisite  corporate  power and is
authorized to

                                       6.
<PAGE>

enter into this Agreement, to purchase the Shares hereunder and to carry out and
perform its obligations under the terms of this Agreement.

         4.2 Due Execution. This Agreement has been duly authorized executed and
delivered by Purchaser, and upon due execution and delivery by the Company, this
Agreement will be a valid and binding agreement of Purchaser.

         4.3 Investment Representations and Covenants.

         Purchaser is acquiring  the Shares for its own account,  not as nominee
or agent,  for  investment  and not with a view to or for  resale in  connection
with,  any  distribution  or public  offering  thereof within the meaning of the
Securities Act.  Purchaser  understands that the Shares have not been registered
under the  Securities  Act, but are instead  being offered and sold to Purchaser
pursuant to an exemption from registration contained in the Securities Act based
in part upon the following representations and warranties:

                  (a) Purchaser is capable of evaluating the merits and risks of
its investment in the Company and has the capacity to protect its own interests.
Purchaser must bear the economic risk of this  investment  unless the Shares are
registered  pursuant to the Securities Act, or an exemption from registration is
available.  Purchaser  understands that the Company has no present  intention of
registering the Shares.  Purchaser also  understands  that there is no assurance
that any exemption from registration  under the Securities Act will be available
and that,  even if available,  such  exemption  may not allow such  Purchaser to
transfer  all or any  portion  of the  Shares  under the  circumstances,  in the
amounts or at the times Purchaser might propose.

                  (b) Purchaser is acquiring the Shares for such Purchaser's own
account for investment only, and not with a view towards their distribution.

                  (c)  Purchaser  represents  that by reason  of its,  or of its
management's,  business or financial  experience,  Purchaser has the capacity to
protect its own interests in connection  with the  transactions  contemplated in
this Agreement.

                  (d) Purchaser has had an  opportunity to discuss the Company's
business,   management  and  financial  affairs  with  directors,  officers  and
management  of the Company and has had the  opportunity  to review the Company's
operations  and  facilities.  Purchaser  has  also  had the  opportunity  to ask
questions of and receive answers from, the Company and its management  regarding
the terms and conditions of this investment.

                  (e) Purchaser  acknowledges and agrees that the Shares must be
held

                                       7.
<PAGE>

indefinitely unless they are subsequently registered under the Securities Act or
an exemption from such registration is available.  Purchaser has been advised or
is aware of the provisions of Rule 144  promulgated  under the  Securities  Act,
which permits limited resale of shares purchased in a private  placement subject
to the satisfaction of certain  conditions,  including,  among other things: the
availability of certain current public information about the Company, the resale
occurring  not less than two years after a party has  purchased and paid for the
security  to  be  sold,  the  sale  being  through  an   unsolicited   "broker's
transaction"  or in  transactions  directly with a market maker (as said term is
defined under the  Securities  Exchange Act of 1934,  as amended (the  "Exchange
Act")) and the number of shares  being sold  during any  three-month  period not
exceeding specified limitations.  Each certificate  representing Shares shall be
stamped  or  otherwise  imprinted  with a legend  substantially  similar  to the
following:

         THE SECURITIES  REPRESENTED  HEREBY HAVE NOT BEEN REGISTERED  UNDER THE
         SECURITIES  ACT OF 1933 (THE  "ACT")  AND MAY NOT BE  OFFERED,  SOLD OR
         OTHERWISE  TRANSFERRED,  ASSIGNED,  PLEDGED OR HYPOTHECATED  UNLESS AND
         UNTIL THEY ARE  REGISTERED  UNDER THE ACT OR UNLESS (A) THE COMPANY HAS
         RECEIVED  AN OPINION OF COUNSEL  SATISFACTORY  TO THE  COMPANY  AND ITS
         COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED OR (B) SUCH SALE IS MADE
         PURSUANT TO RULE 144 UNDER THE ACT.

         4.4 Standstill  Covenant.  Purchaser agrees that neither  Purchaser nor
any of its  affiliates  will in any manner,  directly or indirectly  (i) effect,
seek,  offer or propose to effect any acquisition of any securities or assets of
the  Company,  any  tender or  exchange  offer,  merger,  business  combination,
recapitalization or other extraordinary transaction involving the Company or any
solicitation  of  proxies  or  consents  to vote any  voting  securities  of the
Company,  (ii) form,  join or in any way participate in a "group" (as defined in
the Exchange Act) with respect to any voting  securities  of the Company,  (iii)
solicit or participate in any  solicitation of proxies  relating to the election
of  directors of the Company,  or (iv) enter into any  agreement  with any other
person with  respect to the  foregoing,  or assist any other person to do any of
the foregoing; provided that (A) Purchaser may purchase additional securities in
an  amount  sufficient  to  allow  Purchaser  to own  up to  4.9%  of  the  then
outstanding  shares of Common Stock of the Company  (excluding any shares issued
directly to Purchaser or its  Affiliates  by the  Company);  (B) the transfer of
Shares in accordance  with Section 4.5 and the voting  thereof by the transferee
shall not be deemed a prohibited group formation or proxy solicitation;  and (C)
this sentence  shall not prohibit the  acquisition  or disposition of shares for
investment  purposes  only in the open  market  in the  ordinary  course  by any
pension  fund  or  trust  for the  benefit  of  employees  of  Purchaser  or its
affiliates.

                                       8.
<PAGE>

         4.5 Lockup Covenant.  Purchaser agrees that during the Screening Period
(as defined in the  Collaboration  Agreement),  Purchaser will not,  without the
prior  written  approval of the Company,  offer,  sell or otherwise  dispose of,
directly or indirectly, any capital stock of the Company which Purchaser may own
directly,  indirectly or beneficially;  provided that (i) Purchaser may transfer
some or all of the Shares to a corporation, partnership or other legal entity of
which  Purchaser  has  actual  control,  but only if such  transferee  agrees in
writing to hold such Shares  subject to all of the  provisions of this Agreement
and to  transfer  such  Shares  to  Purchaser  if such  transferee  ceases to be
controlled by Purchaser  (all such Shares so  transferred  shall be deemed to be
shares held by Purchaser  for all  purposes  hereunder),  (ii) the  restrictions
contained in this sentence shall terminate automatically upon the acquisition by
any person or group (as defined in the Exchange  Act),  other than Purchaser and
its  affiliates,  of more than 21% of the outstanding  voting  securities of the
Company,  and  (iii)  this  sentence  shall  not  prohibit  the  acquisition  or
disposition  of shares for  investment  purposes  only in the open market in the
ordinary  course by any pension  fund or trust for the benefit of  employees  of
Purchaser or its affiliates.

5. CONDITIONS TO CLOSING.

         5.1 Conditions to Obligations of Purchaser.  Purchaser's  obligation to
purchase the Shares at the Closing is subject to the fulfillment, at or prior to
the Closing, of all of the following conditions:

                  (a)  Representations  and  Warranties  True;   Performance  of
Obligations. The representations and warranties made by the Company in Section 3
hereof  shall be true and correct in all  material  respects on the Closing Date
with the same  force and effect as if they had been made on and as of said date.
The Company shall have performed all obligations and conditions  herein required
to be performed by it on or prior to the Closing Date.

                  (b)  Proceedings  and  Documents.   All  corporate  and  other
proceedings  in connection  with the  transactions  contemplated  at the Closing
hereby and all documents and instruments  incident to such transactions shall be
reasonably satisfactory in substance and form to Purchaser.

         5.2 Conditions to Obligations of the Company.  The Company's obligation
to issue and sell the Shares at the  Closing is subject to the  fulfillment,  to
the  Company's  satisfaction,  on or  prior  to the  Closing,  of the  following
conditions:

                  (a)  Representations  and Warranties True. The representations
and  warranties  made by Purchaser in Section 4 hereof shall be true and correct
at the  Closing  Date

                                       9.
<PAGE>

with the same force and effect as if they had been made on and as of the date of
the Closing Date.

                  (b) Performance of Obligations. Purchaser shall have performed
and complied with all agreements and conditions  herein required to be performed
or complied with by them on or before the Closing Date, and Purchaser shall have
delivered payment to the Company in respect of its purchase of Shares.

                  (c)Qualifications,   Legal  Investment.   All  authorizations,
approvals,  or permits, if any, of any governmental authority or regulatory body
of the United  States or of any state that are required in  connection  with the
lawful sale and issuance of the Shares at the Closing pursuant to this Agreement
shall have been duly  obtained  and shall be  effective on and as of the Closing
Date.  No stop order or other order  enjoining the sale of the Shares shall have
been  issued and no  proceedings  for such  purpose  shall be pending or, to the
knowledge  of the  Company,  threatened  by  the  SEC  or  any  commissioner  of
corporations  or similar  officer  of any state  having  jurisdiction  over this
transaction.  At the time of the Closing, the sale and issuance of the Shares to
be purchased and sold at the Closing shall be legally  permitted by all laws and
regulations to which Purchaser and the Company are subject.

6.       MISCELLANEOUS.

         6.1 Governing  Law. This  Agreement  shall be governed by and construed
under  the laws of the  State of  California  as  applied  to  agreements  among
California  residents,  made and to be  performed  entirely  within the State of
California, without regard to principles of conflict of laws.

         6.2  Successors  and Assigns.  Except as otherwise  expressly  provided
herein,  the  provisions  hereof  shall  inure to the benefit of, and be binding
upon, the successors,  assigns,  heirs,  executors,  and  administrators  of the
parties hereto.

         6.3 Entire Agreement.  This Agreement and the Exhibits hereto,  and the
other  documents  delivered  pursuant  hereto,  constitute  the full and  entire
understanding and agreement among the parties with regard to the subjects hereof
and no party  shall be liable or bound to any other  party in any  manner by any
representations, warranties, covenants, or agreements except as specifically set
forth  herein or therein.  Nothing in this  Agreement,  express or  implied,  is
intended  to confer  upon any  party,  other than the  parties  hereto and their
respective  successors  and  assigns,  any  rights,  remedies,  obligations,  or
liabilities under or by reason of this Agreement,  except as expressly  provided
herein.

         6.4  Separability.  In case any  provision of this  Agreement  shall be
invalid,  illegal,  or

                                      10.
<PAGE>

unenforceable,  it shall to the extent practicable, be modified so as to make it
valid,  legal and  enforceable and to retain as nearly as practicable the intent
of the parties, and the validity,  legality, and enforceability of the remaining
provisions shall not in any way be affected or impaired thereby.

         6.5 Amendment and Waiver. Except as otherwise provided herein, any term
of this  Agreement  may be  amended,  and  the  observance  of any  term of this
Agreement may be waived (either  generally or in a particular  instance,  either
retroactively  or  prospectively,  and either for a specified  period of time or
indefinitely),  with the  written  consent of the  Company  and  Purchaser.  Any
amendment or waiver  effected in  accordance  with this section shall be binding
upon any  holder of any  security  purchased  under  this  Agreement  (including
securities into which such securities have been  converted),  each future holder
of all such securities, and the Company.

         6.6 Notices. All notices and other communications required or permitted
hereunder  shall be in  writing  and  shall be  deemed  effectively  given  upon
personal  delivery,  on the first  business day  following  mailing by overnight
courier,  or on the fifth day following mailing by registered or certified mail,
return  receipt  requested,  postage  prepaid,  addressed  to  the  Company  and
Purchaser at the addresses included herein.

         6.7 Fees and Expenses.  The Company and Purchaser  shall bear their own
expenses  and legal fees with  respect to this  Agreement  and the  transactions
contemplated hereby.

         6.8  Titles  and   Subtitles.   The  titles  of  the   paragraphs   and
subparagraphs  of this  Agreement are for  convenience of reference only and are
not to be considered in construing this Agreement.

         6.9  Counterparts.  This  Agreement  may be  executed  in any number of
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together shall constitute one instrument.

         6.10  Consent  to  Jurisdiction  and  Venue.  Any claim or  controversy
arising  out of or  related to this  Agreement  or any  breach  hereof  shall be
submitted to a court of applicable  jurisdiction  in the State of California and
each party hereby consents to the jurisdiction and venue of such court.

                                      11.
<PAGE>



         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date set forth in the first paragraph hereof.

                                   SUGEN, INC.




                                   By: /s/ Stephen Evans-Freke
                                       ----------------------------------------
                                       Name:    Stephen Evans-Freke
                                       Title:   Chief Executive Officer and
                                                Chairman of the Board



                                   ASTA MEDICA AKTIENGESELLSCHAFT




                                   By: /s/ Berndt Kastler
                                       ----------------------------------------
                                       Name:    Berndt Kastler
                                       Title:


                                      12.



                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                             UNDER 17 C.F.R. SS.SS.200.80(B)(4),
                                                            200.83 AND 240.24B-2


                            FIRST AMENDMENT TO LEASE

         THIS FIRST AMENDMENT TO LEASE ("Amendment") is entered into as of March
18, 1998 between BRITANNIA POINTE GRAND LIMITED PARTNERSHIP,  a Delaware limited
partnership  ("Landlord") and SUGEN,  INC., a Delaware  corporation  ("Tenant"),
with reference to the following facts:

         A. Landlord and Tenant are parties to a Build-to-Suit  Lease dated June
11, 1997 (the "Lease"),  covering certain  premises  consisting of a building of
approximately  [...***...] square feet to be constructed in the Britannia Pointe
Grand Business Park in South San Francisco, California (the "Center").

         B.  Landlord  and Tenant wish to make  certain  changes in the Lease as
more particularly set forth herein.

         C. Terms  used  herein as defined  terms but not  specifically  defined
herein shall have the meanings assigned to such terms in the Lease.

         NOW,  THEREFORE,  in consideration  of the mutual  agreements set forth
herein and for good and valuable  consideration,  the receipt and sufficiency of
which are hereby acknowledged, Landlord and Tenant agree as follows:

         1. Rent  Commencement  Date.  Section 2.1(a) of the Lease is amended to
read in its entirety as follows:

            "(a) The term of this Lease shall commence upon mutual  execution of
            this Lease by  Landlord  and  Tenant.  Tenant's  minimum  rental and
            Operating  Expense  obligations shall commence on the earlier of (i)
            the  later  of (A)  October  1,  1998 or (B) the  date  which is one
            hundred eighty (180) days after the date Landlord delivers to Tenant
            a  Structural  Completion  Certificate  pursuant  to the  Workletter
            attached hereto as Exhibit C (subject to any adjustments  authorized
            or required  under the  provisions  of such  Exhibit  C),  notifying
            Tenant  that  Landlord's  construction  of the shell of the  Initial
            Building  pursuant  to  Article  5 and  Exhibit  C is  substantially
            complete,  or (ii) the date Tenant takes  occupancy of and commences
            operation  of its business in the Initial  Building,  the earlier of
            such dates being  herein  called the "Rent  Commencement  Date." The
            term of this  Lease  shall end on the day (the  "Termination  Date")
            immediately  preceding the date  seventeen (17) years after the Rent
            Commencement   Date,   unless  sooner   terminated  or  extended  as
            hereinafter provided."

- -----------------
*Confidential Treatment Requested


                                       1.
<PAGE>

         2.  Changes  in Rent  and  Tenant  Improvement  Allowance.  In order to
reflect an increase from $[...***...] pER square foot to $[...***...] per square
foot in Landlord's maximum  contribution  toward the Cost of Improvements of tHE
Tenant Improvements to be constructed pursuant to Section 5.1 and Exhibit C, the
following provisions of the Lease are amended as follows:

             (a) The monthly minimum rental table in Section 3.1(a) of the Lease
is amended to read as follows:

                Months                      Monthly Minimum Rental
                ------                      ----------------------

               001 - 012      $    [...***...]   ($[...***...] per square foot)
               013 - 024           [...***...]   ($[...***...] per square foot)
               025 - 036           [...***...]   ($[...***...] per square foot)
               037 - 048           [...***...]   ($[...***...] per square foot)
               049 - 060           [...***...]   ($[...***...] per square foot)
               061 - 072           [...***...]   ($[...***...] per square foot)
               073 - 084           [...***...]   ($[...***...] per square foot)
               085 - 096           [...***...]   ($[...***...] per square foot)
               097 - 108           [...***...]   ($[...***...] per square foot)
               109 - 120           [...***...]   ($[...***...] per square foot)
               121 - 132           [...***...]   ($[...***...] per square foot)
               133 - 144           [...***...]   ($[...***...] per square foot)
               145 - 156           [...***...]   ($[...***...] per square foot)
               157 - 168           [...***...]   ($[...***...] per square foot)
               169 - 180           [...***...]   ($[...***...] per square foot)
               181 - 192           [...***...]   ($[...***...] per square foot)
               193 - 204           [...***...]   ($[...***...] per square foot)

             (b) Section  3.1(c) of the Lease is amended to read in its entirety
as follows:

                  "(c)   Rental   Adjustment   in   Connection   with   Cost  of
             Improvements.  The  minimum  rental  amounts  specified  in Section
             3.1(a) are based on an  assumed  amount of  [...***...]  per square
             foOT for the Cost of  Improvements  (determined in accordance  with
             Exhibit C) of the Tenant  Improvements  to be constructed by Tenant
             pursuant  to  Section  5.1 and  Exhibit C (and are thus based on an
             assumed amount of [...***...] per square foot for Landlord's  share
             of  such  Cost  OF  Improvements).  Under  no  circumstances  shall
             Landlord's  liability  for such  Cost of  Improvements  exceed  the
             lesser of (i)  [...***...]  of the total Cost of  Improvements  for
             such  Tenant  ImprovemenTS  or (ii)  [...***...]  per  square  foot
             multiplied  by the area of the Initial  Building as  determined  in
             accordance  with Section  3.1(b)  hereof.  If, upon  completion  of
             construction  of the Tenant  Improvements,  it is  determined  that
             Landlord's  share  of the  Cost  of  Improvements  of  such  Tenant
             Improvements (determined in accordance with Exhibit C) is less than
             [...***...]  per square  foot  (using the area of the  Premises  as
             determined  in

- -----------------
*Confidential Treatment Requested

                                       2.
<PAGE>


             accordance  with Section  3.1(b)  hereof),  then the minimum rental
             amounts specified in Section 3.1(a) shall be adjusted as follows:

                  (i) If Landlord's  share of such Cost of  Improvements is less
than  [...***...]  per square foOT but is at least  [...***...] per square foot,
then the minimum  rental under Section  3.1(a) during months 1 through 84 of the
term of this Lease shall be decreased by $[...***...]  per square foot per month
for each  $[...***...] pER square foot by which Landlord's share of such Cost of
Improvements is less than  [...***...] per square foot (prorated for any portion
of such shortfall representing a fraction of $[...***...] per square foot);

                  (ii) If Landlord's  share of such Cost of Improvements is less
than  [...***...]  per square foot but is at least  [...***...] per square foot,
then the minimum  rental under Section  3.1(a) during months 1 through 84 of the
term of this Lease shall be decreased by the sum of (A)  $[...***...] per square
foot per  month  plus (B)  $[...***...]  per  square  foot  per  month  for each
$[...***...]  per  square  foot  by  which  Landlord's  share  of  such  Cost of
Improvements  is less than  [...***...]  per square foot, and the minimum rental
under  Section  3.1(a)  during  months 85 through  120 of the term of this Lease
shall  be  decreased  by  $[...***...]  per  square  foot  per  month  for  each
$[...***...]  per  square  foot  by  which  Landlord's  share  of  such  Cost of
Improvements is less than  [...***...] per square foot (prorated,  in each case,
for any portion of such shortfall  representing a fraction of  $[...***...]  per
square foot); and

                  (iii) If Landlord's share of such Cost of Improvements is less
than  [...***...] per square foot but is more than  [...***...] per square foot,
then the minimum  rental under Section  3.1(a) during months 1 through 84 of the
term of this Lease shall be decreased by the sum of (A)  $[...***...] per square
foot per  month  plus (B)  $[...***...]  per  square  foot  per  month  for each
$[...***...]  per  square  foot  by  which  Landlord's  share  of  such  Cost of
Improvements is less than [...***...] per square foot, the minimum rental during
months 85 through  120 shall be  decreased  by the sum of (C)  $[...***...]  per
square foot per month plus (D)  $[...***...]  per square foot per month for each
$[...***...]  per  square  foot  by  which  Landlord's  share  of  such  Cost of
Improvements  is less than  [...***...]  per square foot, and the minimum rental
during months 121 through 168 shall be decreased by $[...***...] per square foot
per month for each  $[...***...]  per square foot by which  Landlord's  share of
such Cost of Improvements is less than [...***...] per square foot (prorated, in
each  case,  for any  portion  of such  shortfall  representing  a  fraction  of
$[...***...]  per square  foot)." 

             (c)  Section  3.1(d) of the Lease is  amended by  changing  the two
references therein to a figure of [...***...] per square foot to read,  instead,
[...***...] per square foot.

             (d) Section  20.1 of the Lease is amended to increase the amount of
the Security  Deposit required  thereunder from [...***...] to [...***...].  (e)
Paragraph 4(b) of Exhibit C to the Lease (the  Workletter) is amended to read in
its entirety as follows:

                  "(b) Tenant's Work. Except as otherwise  expressly provided in
             this  Workletter  or by mutual  written  agreement  of Landlord and
             Tenant,  the cost of

- -----------------
*Confidential Treatment Requested

                                       3.
<PAGE>

             construction of the Tenant  Improvements shall be borne [...***...]
             by Landlord and [...***...] by Tenant,  up to a maximum  Landlord's
             obligation of $[...***...]  per square foot of space in the Initial
             Building (measured in accordance with Section 3.1(b) of the Lease),
             equating   to  a  total  Cost  of   Improvements   for  the  Tenant
             Improvements  of  $[...***...]  per square  foot.  Tenant  shall be
             responsible,   at  its  sole  cost  and  expense  (subject  to  any
             third-party  financing  arrangements  entered  into  by  Tenant  as
             contemplated  in  Section  11.4  of  the  Lease),  for  payment  of
             [...***...] of the first  $[...***...]  per square foot of the Cost
             of Improvements of the Tenant Improvements,  for the entire Cost of
             Improvements  of the Tenant  Improvements in excess of $[...***...]
             per square foot (if any such excess occurs) and for the entire cost
             of any Tenant's  Work that is not part of the Tenant  Improvements,
             including  (but not limited  to),  in each case,  any costs or cost
             increases incurred as a result of Unavoidable Delays,  governmental
             requirements or  unanticipated  conditions.  If Landlord's share of
             the Cost of  Improvements  of the Tenant  Improvements is less than
             $[...***...]  per square foot in the aggregate,  the amount of such
             difference shall result in a rental adjustment  pursuant to Section
             3.1(c) of the Lease.  The timing,  conditions and other  procedures
             for payment or disbursement of Landlord's  share of the cost of the
             Tenant  Improvements  (up to the maximum  amount  specified  above)
             shall be  subject  to mutual  agreement  of  Landlord,  Tenant  and
             Landlord's  lender (if any). To the extent the Cost of Improvements
             with respect to the Tenant  Improvements  exceeds  $[...***...] per
             square foot (reduced by  [...***...]  of any amounts  deducted from
             Landlord's  maximum  payment  obligation  as a result  of the final
             sentence of Paragraph  4(a) hereof),  whether as a result of Change
             Orders,  Tenant Delays and/or Unavoidable Delays or otherwise,  the
             amount  of  such  excess  shall  in all  events  be  Tenant's  sole
             responsibility and expense."

         3. Stock Warrants. In partial consideration for Landlord's agreement to
enter into this  Amendment  and to make a larger  tenant  improvement  allowance
available to Tenant as described  above,  Tenant  agrees to issue and deliver to
Landlord or Landlord's  assignees  (which may be any partners,  shareholders  or
affiliates of Landlord or any affiliates of any such partners,  shareholders  or
affiliates  of  Landlord)  warrants  registered  in  the  name  of  Landlord  or
Landlord's  assignees,  as  applicable,  for the  acquisition of an aggregate of
[...***...] shares of Tenant's common stock (the "Additional  Warrants"),  which
Additional  Warrants shall be in addition to, but (except as otherwise expressly
provided  below)  shall be in  substantially  the same  form  as,  the  warrants
previously  issued  by  Tenant  pursuant  to  Section  4.1(a)  of the  Lease for
[...***...] shares (in the aggregate) of Tenant's common stock.  Notwithstanding
the preceding sentence,  the Additional Warrants shall have an exercise price of
$[...***...]  per  share,  shall be dated as of the date of this  Amendment  and
shall  be  exercisable  for a  period  of  [...***...]  years  from  the date of
issuance.

         4. Use of Union Labor.

- -----------------
*Confidential Treatment Requested

                                       4.

<PAGE>

             (a) The fourth  sentence of Section 11.1 of the Lease,  relating to
the use by Tenant of union contractors for improvements,  alterations, additions
and like matters, is deleted in its entirety.

             (b) Paragraph 5(a) of the  Workletter  attached as Exhibit C to the
Lease is amended to read in its entirety as follows:

                  "(a) Contractor Requirements. The contractor engaged by Tenant
             for Tenant's Work, and any  subcontractors,  shall be duly licensed
             in  California  and shall be subject to  Landlord's  prior  written
             approval,  which  approval  shall not be  unreasonably  withheld or
             delayed."

         5. Full Force and Effect.  Except as expressly  set forth  herein,  the
Lease has not been modified or amended and remains in full force and effect.

         6. Landlord's Notice Address.  The notice address for Landlord,  as set
forth in Section 21.1 of the Lease, is hereby changed to the following:

             Britannia Pointe Grand Limited Partnership
             1939 Harrison Street, Suite 715
             Park Plaza Building
             Oakland, CA  94612
             Attn:  T. J. Bristow

         IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as
of the date first set forth above.

"Landlord"                                  "Tenant"

BRITANNIA POINTE GRAND LIMITED              SUGEN, INC., a Delaware corporation
PARTNERSHIP, a Delaware limited
partnership
                                            By:      /s/ Stephen Evans-Freke
By:  BRITANNIA POINTE GRAND,                         ---------------------------
     LLC, a California limited liability             Stephen Evans-Freke       
     company, General Partner                        Its Chairman and Chief    
                                                     Executive Officer         
                                                     

By:  /s/ T.J. Bristow                       By:      /s/ Susan Kanaya
     ------------------------------                  ---------------------------
     T. J. Bristow                                   Susan Kanaya
     President & Manager                    Its:     Treasurer


                                       5.

<TABLE> <S> <C>

<ARTICLE>                     5
<LEGEND>
THE SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE COMPANY'S
FORM 10-Q FOR THE THREE  MONTHS  ENDED  MARCH 31, 1998 AND IS  QUALIFIED  IN ITS
ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                              DEC-31-1998
<PERIOD-START>                                 JAN-01-1998
<PERIOD-END>                                   MAR-31-1998
<CASH>                                         10,301
<SECURITIES>                                   57,978
<RECEIVABLES>                                       0
<ALLOWANCES>                                        0
<INVENTORY>                                         0
<CURRENT-ASSETS>                               69,368
<PP&E>                                         12,016
<DEPRECIATION>                                  7,734
<TOTAL-ASSETS>                                 77,508
<CURRENT-LIABILITIES>                          16,015
<BONDS>                                        20,441
                               0
                                         0
<COMMON>                                      142,686
<OTHER-SE>                                   (101,634)
<TOTAL-LIABILITY-AND-EQUITY>                   77,508
<SALES>                                             0
<TOTAL-REVENUES>                                1,645
<CGS>                                               0
<TOTAL-COSTS>                                       0
<OTHER-EXPENSES>                                9,432
<LOSS-PROVISION>                                    0
<INTEREST-EXPENSE>                                468
<INCOME-PRETAX>                                (9,121)
<INCOME-TAX>                                        0
<INCOME-CONTINUING>                            (9,121)
<DISCONTINUED>                                      0
<EXTRAORDINARY>                                     0
<CHANGES>                                           0
<NET-INCOME>                                   (9,121)
<EPS-PRIMARY>                                   (0.59)
<EPS-DILUTED>                                   (0.59)
        


</TABLE>


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